Molecule triggering an immune response (antibody production) in the host
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In this episode, we detail the role of immunoglobulins in gut-immune function, examining their involvement in mucosal defense, microbial regulation, and immune homeostasis within the intestines. We discuss the mechanisms of antibody production, highlighting how secretory IgA (sIgA) contributes to intestinal barrier integrity and pathogen neutralization. We also detail low secretory immunoglobulin A levels and Candida overgrowth. Lastly, we go through tools to support the gut-immune axis including oral immunoglobulin supplementation.1. Introduction - Overview of immunoglobulins, roles in gut-immune health - The gut as a constant interface with antigens, microbes, and potential pathogens - Adequate but balanced immunoglobulin levels; preventing opportunistic pathogen overgrowth 2. Immunoglobulins - Immunoglobulins (Ig) as glycoproteins, fundamental role in immune defense - Five major immunoglobulin isotypes and their distinct roles - How immunoglobulins recognize and neutralize pathogens / toxins / foreign antigens 3. Antibody Production in the Intestines - Naïve B cells originate in the bone marrow, migrate to secondary lymphoid tissues - Antigen-presenting cells (APCs) facilitate antigen processing and B cell activation - Plasma cells and mucosal immunity 4. The Intestinal Barrier and Immune Components - Layers of the gut barrier and their functions - The role of gut-associated lymphoid tissue (GALT) in immune surveillance - Immune cells within the lamina propria and their contributions to gut homeostasis 5. Secretory IgA (sIgA) and Its Role in Gut Immunity - sIgA production and transport across the intestinal epithelium - Role of sIgA in immune exclusion and pathogen neutralization 6. Factors That Can Influence sIgA Levels - Chronic stress, infections, and gut inflammation as contributors to low sIgA - Consequences of low sIgA, including increased susceptibility to pathogens - Nutrients essential for supporting optimal sIgA levels 7. Other Key Immunoglobulins in Gut Immunity - Immunoglobulin G's role in immune responses / pathogen neutralization - Immunoglobulin M's location and function as an early immune responder in mucosal defense 8. Supplemental Immunoglobulins - Oral immunoglobulin supplementation and its benefits - Bovine colostrum as a source of immunoglobulins for intestinal and immune support 9. Conclusion - Recap of immunoglobulins' role in gut-immune function - The importance of balanced IgA, IgG, and IgM levels - Strategies to support gut immunityThank you to our episode sponsor:1. Shop CYLN's full skincare line here.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Track listing: Kaigal-ool Khovalyg and Anatoli Kulaar – Xöömei On Horseback KMD - Mr Hood at Piocallee Jewelry / Crackpot Kimya Dawson – Tire Swing The Kinks – A Well Respected Man Kagoule – Glue Keely Smith – What is this Thing Called Love? Kids See Ghosts – 4th Dimension (feat. Louis Prima) Kim Deal – Coast Killer Mike – Big Beast (feat. Bun B, T.I. & Trouble) Killing Joke – The Pandys Are Coming Kesane Quartet – Janghi KaddalMerrill – Sim Sim Kronos Quartet – Spoonful Kulk – Lives for One Kristin Hersh – Shake Kofi Flexxx – Apothecary (feat. billy woods) Kraftwerk – Ruckzuck Koudede – Tassakkne Tara K. McCarty - Grievances Killdozer – King of Sex Kid Acne and Spectacular Diagnostics – Flame Wars (feat. Taja) The KLF v ENT – 3AM Eternal Kate Bush – Sat in Your Lap The Knife – Full of Fire Kendrick Lamar – King Kunta
Track listing: John Davis and Group – Moses, Don't Get Lost John Oswald – Power Jolie Holland – Old Fashioned Morphine Jane's Addiction – Rock ‘n' Roll E. Mainer and Band – Three Nights Drunk Jason Griff – The One (feat. Billa Camp, King Micah the Infamous, DoamPeace & Rapswell) Julian Cope – Up-Wards at 45° Jethro Tull – ... And the Mouse Police Never Sleeps The Jesus Lizard – Lady Shoes Julee Cruise – Mysteries of Love Jacques Thollot – Cécile John Callaghan – Get On Your Box Jeffrey and Jack Lewis – Moving The Jon Spencer Blues Explosion – Attack Jay-Z / The Beatles – 99 Problems Junior Kimbrough – Done Got Old Johnny Cash – Blue Train Jack Rundell – Death Clock J Mascis + The Fog – More Light Joanna Newsom – Good Intentions Paving Co. Jim Nollman – Vihuela and Wolf Pack #One Joy Division – Shadowplay Jandek – European Jewel (Incomplete) The Jesus and Mary Chain – Vegetable Man John Coltrane – Part 1: Acknowledgement Joseph Spence and the Pinder Family – I Bid You Goodnight JPEGMAFIA – ALL CAPS NO SPACES
Dr. Tara Reid from the University of Washington Division of Allergy & Infectious Diseases and Dr. Meena Ramchandani discuss Dr. Reid's recent study to identify key T. pallidum proteins which stimulate CD4 T cell response to syphilis. View episode transcript and reference at www.std.uw.edu.This podcast is dedicated to an STD [sexually transmitted disease] review for health care professionals who are interested in remaining up-to-date on the diagnosis, management, and prevention of STDs. Editor and host Dr. Meena Ramchandani is an Assistant Professor of Medicine at the University of Washington (UW) and Program Director of the UW Infectious Diseases Fellowship Program.
Sanjeev Sethi, M.D., Ph.D., explains how Mayo Clinic Laboratories' new mass spectrometry test (Mayo ID: MSMN) identifies most antigens now known to cause membranous nephropathy. Precise identification of antigens is important for optimal management of this serious kidney disease.Speaker 3: (00:32) Would you mind telling us a little bit about yourself and your background? Speaker 3: (01:58) Would you give us an overview of membranous nephropathy? Speaker 3: (07:14) Could you tell us a little bit about this new assay? Speaker 3: (14:29) Could you give a little example of how a clinician might use this information to treat their patients differently than how they would've in the past?
New Year, same old format. The planet may have travelled 584 million miles since January 2024, but the show has only inched as far as the I section of the Antigen HQ record collection. Jason celebrates his lack of progress with a selection of deep excavations from the land of polar darkness and revelations from the regions of immortal light. Track listing: Imperial Household Orchestra – Ise'-no-Uni In Slaughter Natives – Death just only death... I.D. Beck – Poor Pilgrim of Sorrow Immortal Technique – Bin Laden (ft. Mos Def) The Indians of the Chocó – Healing Song Ichi – Go Gagambo Rev. I.B. Ware with Wife and Son – I Wouldn't Mind Dying (But I Gotta Go By Myself) Iggy and the Stooges – Search and Destroy (Stooges mix) Ice Cube – Wicked Iron and Wine – Die Italian Books – Neest Gulp (Remixed by there are no birds here) Idles – Pop Pop Pop (ft. Danny Brown) Iggy Pop – The Passenger (Live in Manchester 1977) I Z - 冶铁的风箱 Iglooghost – Nemat0de Interpol – Obstacle 1 Ice T – The Tower The Incredible String Band – Lordly Nightshade Ivanka Georgieva – Gledai Me, Gledai Aishe Isabel Sutherland – Dance with Me, Morag Ivor Cutler – Life in a Scotch Sitting Room Vol. 2 Ep II The International Debt – When I Say Us I Mean You Ian Dury – Razzle in My Pocket Isobel Campbell and Mark Lanegan – Time of the Season The Isley Brothers – Fight the Power (Parts 1 & 2) The Indian Bottom Association of Old Regular Baptists – Sweet Glories Rush upon My Sight Illusion of Safety – Scratching the Surface
In this week's episode we'll learn more about an experimental regimen for classical Hodgkin lymphoma that combines brentuximab vedotin, nivolumab, and chemotherapy; a possible role for type 1 interferon signaling in developing autoantibodies to red blood cells in sickle cell disease; and how genomic alterations affecting class I human leukocyte antigen molecules may affect patients with cutaneous T-cell lymphoma. Featured Articles:Brentuximab vedotin, nivolumab, doxorubicin, and dacarbazine for advanced-stage classical Hodgkin lymphomaIFN-I promotes T-cell–independent immunity and RBC autoantibodies via modulation of B-1 cell subsets in murine SCDGenetic alteration of class I HLA in cutaneous T-cell lymphoma
The Duffy antigen, also known as the Duffy antigen receptor for chemokines (DARC), plays a critical role in immune system regulation and disease processes. It is a protein found on the surface of red blood cells and endothelial cells, known primarily for its function as a receptor for chemokines and its role in malaria resistance. However, emerging research has highlighted a fascinating link between the Duffy antigen and systemic lupus erythematosus (SLE), an autoimmune condition. In individuals with lupus, the immune system becomes overactive, targeting the body's own tissues and causing widespread inflammation. The Duffy antigen has been implicated in this process because of its role in modulating immune responses. Specifically, DARC binds to and regulates the levels of chemokines, proteins that guide immune cells to sites of inflammation. Dysregulation of this pathway may contribute to the heightened immune activity observed in lupus. Additionally, certain genetic variations in the Duffy antigen, such as the Fy(a-b-) phenotype, which is common in individuals of African descent, have been associated with altered susceptibility to autoimmune diseases, including lupus. These variations may influence the way the immune system interacts with chemokines and other inflammatory signals. Understanding the relationship between the Duffy antigen and lupus opens new doors for research, offering insights into the genetic and molecular underpinnings of the disease. This connection also holds promise for developing targeted therapies aimed at modulating immune responses in lupus patients, potentially improving outcomes and quality of life. By exploring the link between the Duffy antigen and lupus, scientists are unraveling the complex interplay between genetics, immune regulation, and autoimmunity, providing hope for better treatments and a deeper understanding of this challenging condition.
Erkrankungen entdecken, solange man sich noch gesund fühlt: Vorsorgeuntersuchungen versprechen grossen Nutzen. Spätestens ab 50 wird einem eine ganze Palette an Abklärungen empfohlen – die aber auch das Risiko von Überdiagnosen bergen. «Puls» zeigt, welche Check-ups wann wem wirklich etwas bringen. Dickdarmkrebs-Vorsorge: Nützlich, aber wenig genutzt In der Schweiz erkranken jährlich rund 4500 Personen an Dickdarmkrebs. Frühzeitig erkannt, ist diese Krebsart meistens heilbar. Trotzdem hat in den letzten zehn Jahren nur gut die Hälfte der anvisierten Zielgruppe eine entsprechende Vorsorgeuntersuchung machen lassen. Was sind die Gründe? Und wie liesse sich die Screening-Rate verbessern? Mammografie und PSA-Test: Populär, aber umstritten Die Röntgenuntersuchung der weiblichen Brust und die Bestimmung des Prostata-spezifischen Antigens im Blut (PSA) können Hinweise auf eine Krebserkrankung liefern. Im Frühstadium entdeckt, können dadurch schonendere Therapien angeboten werden. Ob der augenfälligen Vorteile gehen die Nachteile wie falsch-positive Befunde, Überdiagnose und Übertherapie gerne unter. Familiäre Risiken: Pascale Menzi lässt sich abklären Kommen gewisse Erkrankungen in einer Familie gehäuft vor, spricht man von einem familiären Risiko: Die Veranlagung für einige Krebsarten, Herzfehler oder krankhafte Gefässerweiterungen kann weitervererbt werden. Beim Vater von «Puls»-Moderatorin Pascale Menzi wurde zufällig ein Bauchaortenaneurysma entdeckt. Muss sie sich deshalb nun auch Sorgen machen? «Puls»-Chat zum Thema «Vorsorgeuntersuchungen» Haben Sie Bedenken vor einer Darmspiegelung und fragen sich, ob der Blut-im-Stuhl-Selbsttest eine ebenbürtige Alternative wäre? Möchten Sie mehr über die Vor- und Nachteile einer Mammografie erfahren? Ist Hautkrebs ein Thema in Ihrer Familie und wollen Sie mehr über das persönliche Risiko wissen? Die Fachrunde weiss am Montag von 21.00 bis 23.00 Uhr Rat – live im Chat. Fragen können vorab eingereicht werden. «Puls kompakt»: Vier beliebte Vorsorgeuntersuchungen im Check Hautkrebs, Grüner Star, Herz-Kreislauf-Erkrankungen und humane Papillomaviren HPV. Wie schützt man sich davor und was bringen regelmässige Check-ups? «Puls kompakt» ordnet ein.
Immunology is a key area in biotech and biopharma, both in terms of R&D and sales.However, according to UK-headquartered Greywolf Therapeutics, the industry has only focused on two-thirds of the puzzle.To have an immunological effect, you must activate the body's T cells, which cells requires a chain of three key signals. The first is antigen recognition, i.e. the initial detection of a cell by a T-cell. The second is the co-stimulation of non-antigen presenting molecules, which enhances the immune response. The final step is cytokine-mediated differentiation and expansion, which guides how T-cells target threats. Companies have focused on the second two signals, with signal 2 most commonly seen in therapies such as checkpoint inhibitors and monoclonal antibodies. Signal 3, on the other hand, can be primarily seen in therapies for autoimmune disorders, such as anti-TNF and JAK inhibitors.Greywolf Therapeutics is the first company to explore changing signal 1. The company says focusing on signal 1 applies in three key therapeutic areas: oncology, autoimmunity and virology. Greywolf's first candidate has delivered a robust response during its ongoing phase I/II trial in oncology, therefore demonstrating proof-of-mechanism and target engagement, with its next candidate well-progressed in preclinical development in autoimmunity.To tell us more about the company and its work is Pete Joyce, CEO and co-founder of Greywolf Therapeutics.01:19-04:12: About Greywolf Therapeutics04:12-04:51: The origins of the name04:51-06:52: The three ‘signals' of the mechanics of immunological responses06:52-08:31: Treatments associated with each signal08:31-10:09: Why is step 1 important, and why has it not been investigated for treatments?10:09-11:28: What areas of disease is this applicable to?11:28-12:19: How do you inhibit ERAP?12:19-14:01: Greywolf Therapeutics' candidates14:01-15:11: How is this an advance on current treatments?15:11-16:05: What is success for patients?16:05-17:20: How does the stage of disease affect treatment?17:20-18:09: Are other companies looking into antigen modulation? 18:09-19:47: Has this led to investment opportunities?19:47-21:15: Next steps21:15-21:55: Do you anticipate more interest in this space?21:55-23:21: Attending events Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletter
In today's episode, we dive into the interplay between the gut and immune system, focusing specifically on the critical role of immunoglobulins in mucosal immunity. Immunoglobulins, specialized glycoproteins synthesized by B cells, serve as the frontline defenders within the gastrointestinal tract, where they neutralize pathogens and maintain immune homeostasis. We also explore the mechanisms by which these antibodies fortify the intestinal barrier and aid in preventing dysbiosis. We finish by going through tools for supporting immunoglobulins. Topics: 1. Introduction - Overview of the gut-immune axis and focus on immunoglobulins. - How low levels of immunoglobulins can contribute to dysbiosis. 2. What Are Immunoglobulins? - Immunoglobulins (Igs) are glycoproteins produced by B cells. - They play a critical role in recognizing and neutralizing pathogens. - Antigen-binding sites for specific targeting. - Essential for immune homeostasis and pathogen elimination. 3. Immunoglobulins' Role in the Gut - Protect mucosal surfaces exposed to antigens. - B cells differentiate into plasma cells, and secrete immunoglobulins into the gut lumen. 4. Layers of the Intestinal Lining - Intestinal lumen is covered by a protective mucus layer. - Mucosa consists of epithelial cells, including mucus-secreting goblet cells. - Lamina propria beneath the epithelium is rich in immune cells. - Submucosa beneath mucosa. 5. The Function of the Mucus Layer - Acts as a physical barrier against pathogens. - Functions as a biochemical barrier by housing antimicrobial peptides and immunoglobulins. - Primarily composed of mucins secreted by goblet cells. - Goblet cells release mucins in response to stimuli, forming gel-like mucus. 6. Introduction to Secretory Immunoglobulin A (sIgA) - sIgA is the most abundant immunoglobulin in mucosal secretions. - Forms a protective barrier in the mucus layer. - Plays a critical role in immune exclusion by trapping and neutralizing pathogens. - Helps maintain non-inflammatory defense at mucosal surfaces. 7. Production of Secretory IgA - Plasma cells in the lamina propria secrete IgA. - IgA binds to receptors on epithelial cells and is transported across to the gut lumen. - sIgA to neutralize pathogens effectively within the mucus layer. 8. Functions of Secretory IgA in the Gut - Binds to antigens like bacterial walls, viruses, and toxins. - Traps antigens in the mucus to prevent adherence to epithelial cells. - Provides immune exclusion, reducing pathogen access to the gut lining. - Maintains mucosal barrier integrity to prevent inflammation. 9. Impact of Low sIgA Levels - Contributes to dysbiosis by allowing pathogenic bacteria to proliferate. - Intestinal hyperpermeability. - Increased risk of intestinal inflammation and infections. 10. Comparison with Other Immunoglobulins: IgG and IgM - IgG is most abundant in blood. - IgM is produced early in immune responses. - IgM can also be secreted into the gut lumen in IgA deficiency. 11. Immunoglobulin Supplements - IgG supplements. - Colostrum: IgG to help neutralize pathogens. - Supports gut barrier integrity. 12. Supporting Immunoglobulin Levels - Colostrum - Probiotics, prebiotics - Vitamin A - Zinc 13. Conclusion - Immunoglobulins, intestinal health, and immune balance. Thanks for tuning in! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Track listing: Happy Flowers – Left Behind Half Japanese – Deadly Alien Spawn Hobart Smith – Wabash Blues Honeymoon in Red – Done Dun Helios Creed – Lactating Purple Henry Homesweet – Scream HIRS Collective – XOXOXOXOXOX (ft. Melt Banana) Hex Minora – Genius Daimon Hail – The Poets The Homosexuals – Vociferous Slam Horse Party – Receiver Hack-Poets Guild – Rare Receipts Huun-Huur-Tu – Prayer Harappian Night Recordings – Headless Mule Hanged Up – Winternational Hank Williams and the Drifting Cowboys – I'll Have a New Body Holly Golightly – Come the Day The Hives – Outsmarted Headbutt – Facial Towtruck IV Hanatarash – Dub Dub Overlord Harry Pussy – Showroom Dummies Half Man Half Biscuit – National Shite Day Heather Nova – Shaking the Doll Hole – Dicknail Head of David – Bugged Harry Partch – Castor Hush Arbors – Rue Hollow Hair OST – Three-Five-Zero-Zero/What a Piece of Work is Man/Walking in Space (Reprise) Heavenly Gospel Singers – Go Where I Send Thee
Track listing: Armand Hammer – Doves Sealionwoman – Charcoal The Bug – Deep in a Mud (ft. Magugu) Kulk – Life Will Wait Melt Banana – Loop Nebula There Are No Birds Here – Main Village Scotch Rolex, Shackleton and Omutaba – Burnt Earth Shrapknel – Illusions of P BUÑUEL – Drug Burn Wusa – AWJUKHA (Absolution) Tom Waits – Get Behind the Mule (Spiritual) Exuma – Dambala Matt Sweeney and Bonnie ‘Prince' Billy – Blood Embrace Low – Violent Past
Gastric cancer is a leading cause of cancer death globally. Chronic H pylori infection is the primary cause of gastric cancer, responsible for at least 80% of the new cases. Constanza Camargo, PhD, of the National Cancer Institute joins JAMA Associate Editor John M. Inadomi, MD, to discuss co-testing with FIT and H pylori stool antigen to help prevent gastric cancer. Related Content: Fecal Immunochemical Test and Helicobacter pylori Stool Antigen Co-Testing Screening for Helicobacter pylori to Prevent Gastric Cancer
Join Jason as he raises a pint of whelks to the seaside people of Essex, to celebrate their contribution to British democracy. He bids farewell to the big beasts of modern Conservatism, commemorating the characters who have selflessly served up content for the show over the last four and a half years. Plus, context-free Hitler appreciation, Captain Mordaunt's marine threat index, and international music from the mean streets of Monte Carlo to the cultural capital of Essex, Clacton-on-Sea. Track list: Wil Bolton – Boarded Up Cardiacs – Red Fire Coming Out From His Gills Sealionwoman – Butcher's Broom Groff – Off & On Napalm Death – To Go Off and Things White Noise – Here Come the Fleas Rad Pitt – I Went to Bristol and Saw Macaulay Culkin on a Boat Once Ben Brown – Blue DSHappyBoi – “I think socialism is r*t*rded” – Frank Turner 2009 Lee Ashcroft – Gutter Rave ShitNoise – Brown Morning Regina Spektor – Poor Little Rich Boy My Bloody Valentine – Emptiness Inside Shellac – The End of Radio
In this episode, we dive into the critical role of HLA gene variants, such as HLA-DRB1, and their profound impact on immune system function, particularly focusing on their significance in conditions like Lyme disease and mold toxicity. We'll explore how variations in these HLA genes, like the HLA-DRB1*0401 allele, influence the body's ability to recognize and respond to pathogens, potentially leading to chronic symptoms. The discussion will also cover HLA gene variant testing and how it can lend insight when it comes to taking a bioindividual approach to supporting the immune system. Topics: 1. Introduction - Explanation of HLA gene variants - Importance of HLA genes in immune system function 2. Basics of Genetics and Immunology - What is a chromosome? - Introduction to genes and their functions - Overview of DNA and protein synthesis 3. Major Histocompatibility Complex (MHC) - Description of the Major Histocompatibility Complex - Division of MHC genes into Class I, II, and III - Role of Class I MHC genes in antigen presentation - Role of Class II MHC genes in antigen presentation - Function of Class III MHC genes 4. HLA Genes and Immune Function - Explanation of Human Leukocyte Antigen (HLA) genes - Connection between MHC genes and HLA genes (human MHC) - Transcription and regulation of HLA genes - Response to internal and external signals - Role of Antigen-presenting cells (APCs) 5. Pathogen Recognition and Immune Activation - Mechanism of pathogen recognition by HLA genes - Activation of immune response by antigen presentation - Formation and function of peptide-HLA complexes 6. Impact of HLA Variants on Disease - Specific focus on Lyme disease and mold toxicity - Role of HLA Class II alleles in immune response - Association of HLA-DR alleles with chronic Lyme disease - Sensitivity to mold exposure linked to certain HLA gene variants 7. Testing and Implications of HLA Gene Variants - Importance of HLA gene variant testing - Broader implications for diseases like lupus and multiple sclerosis - Personalized approaches based on HLA gene variants 8. Biotoxin Illness and Poor Antigen Presentation Due to an HLA Gene Variant - Strategies to support immune system function in the presence of biotoxins - Importance of detoxification pathways and binders Thank you to our episode sponsor: Liver Medic Use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support
Do you know your blood type?
Track listing: CLT DRP – Until You Showed Me This Heel – Infinite Stunts Marc Newby – Feeling Feeder The 180Gs – The Dust Blows Forward n the Dust Blows Back 1st Naumati Baja Gulmi UK – Jham Jham Parili JPEGMAFIA – Don't Rely on Other Men Kulk – Life Will Wait Senyawa – Vajranala Otay:onii – Intentions and Emotions Reducer – Sleng Teng Masters Erick – Adam in the Garden Scudamor Ziadune – The Drugnow Lee Ashcroft – Lodestar Violence Gratuite – Baleine à Boss
Specialist hired by more plates more dates and host of the Dr. Adam Hotchkiss YouTube channel. Dr. Hotchkiss specializes in health and performance optimization and body composition and also has had a host of personal experience experimenting with PED's an anabolic steroids. This was epic. Thanks for sharing your insights Dr. AdamPlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story https://www.instagram.com/trensparentpodcast/Watch The Podcast:https://www.youtube.com/channel/UCqgN2kieCEHwZ9M-QFBxfCgPharma TRT, GH analogs, peptides, IGF-1, var troche, fat-loss/hair-loss treatments, etc | HRT Men's Health Optimization: https://transcendcompany.com/patient-intake-form/?ls=Nyle+NaygaHuge Elements Line (astragalus, citrus bergamot, etc): https://hugesupplements.com/collections/elementsCode 'NYLE' for 10% off - proceeds go towards upgrading content productionHuge Supplements (Protein, Pre, Utilize, Vital): https://hugesupplements.com/?aff=165Support code 'NYLE' 10% offYoungLA Clothes: https://www.youngla.com/discount/nyleYoungLA For Her: https://www.youngla.com/collections/all-products-1/For-HerCode ‘NYLE' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastCoaching | Personalized program: https://www.nylenaygafitness.comTimestamps:00:00:00 - Teaser & Intro00:00:44 - TRT vs Steroids00:05:56 - Expectations & Intensions00:08:08 - Love & Gear00:09:43 - Sex drive00:17:04 - Were you cheating?00:18:53 - Are you natty?00:20:27 - Mustache & Tattoos00:27:03 - Should you jump on gear?00:28:01 - Regretting decisions00:29:25 - “More plates, More dates”00:30:29 - Do you still powerlift?00:31:31 - Gear Risk mitigation00:33:40 - Blood pressure00:37:47 - When to stop smoking?00:40:09 - Effects on kidneys from gear 00:43:35 - No Gyno00:46:26 - Insulin resistance00:47:40 - Berberine & Metformin blunting hypertrophy00:50:09 - Have you ever taken Berberine?00:54:08 - Ancillaries recommendations for Neuroprotective reasons00:57:17 - Natto00:58:15 - Thoughts on cycle supports01:00:21 - Genetic Predispositions01:03:13 - When should someone use precursor hormones?01:05:36 - Gear vs HRT01:08:20 - Halotestin Monotherapy01:14:29 - Antigen receptor vs drug tolerance01:15:36 - Anavar for burn victims01:17:25 - Ziegler Monster01:22:07 - Thoughts on SARM01:24:21 - “Yellow filter”01:32:49 - Q & A01:34:29 - Bloodwork01:47:49 - How to increase load size as a chick?01:50:02 - Last question#psychology #stories #podcast #mentalhealth #discipline #selfdevelopment #personaldevelopment #fitness #ifbbpro #npc #bodybuilder #bodybuilding #tiktok #shizzy #olympia #mrolympia #2023olympia #selfimprovement #workout #gym #nutrition #mensphysique #classicphysique #love #discipline #relationships #chrisbumstead #tren #workout #gym #trt #hormones #discipline #hardstyle #steroids #larrywheels
BUFFALO, NY- May 8, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 7, 2024, entitled, “Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN.” The sequential PET/CT studies oncology patients can undergo during their treatment follow-up course is limited by radiation dosage. In this new study, researchers Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, and Stephanie A. Harmon from the National Institutes of Health's National Cancer Institute proposed an artificial intelligence (AI) tool to produce attenuation-corrected PET (AC-PET) images from non-attenuation-corrected PET (NAC-PET) images to reduce need for low-dose CT scans. “AI-generated PET images has clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality in prostate cancer patients.” Methods: A deep learning algorithm based on 2D Pix-2-Pix generative adversarial network (GAN) architecture was developed from paired AC-PET and NAC-PET images. 18F-DCFPyL PSMA (prostate-specific membrane antigen) PET-CT studies from 302 prostate cancer patients, split into training, validation, and testing cohorts (n = 183, 60, 59, respectively). Models were trained with two normalization strategies: Standard Uptake Value (SUV)-based and SUV-Nyul-based. Scan-level performance was evaluated by normalized mean square error (NMSE), mean absolute error (MAE), structural similarity index (SSIM), and peak signal-to-noise ratio (PSNR). Lesion-level analysis was performed in regions-of-interest prospectively from nuclear medicine physicians. SUV metrics were evaluated using intraclass correlation coefficient (ICC), repeatability coefficient (RC), and linear mixed-effects modeling. Results: Median NMSE, MAE, SSIM, and PSNR were 13.26%, 3.59%, 0.891, and 26.82, respectively, in the independent test cohort. ICC for SUVmax and SUVmean were 0.88 and 0.89, which indicated a high correlation between original and AI-generated quantitative imaging markers. Lesion location, density (Hounsfield units), and lesion uptake were all shown to impact relative error in generated SUV metrics (all p < 0.05). “The Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.” DOI - https://doi.org/10.18632/oncotarget.28583 Correspondence to - Stephanie A. Harmon - stephanie.harmon@nih.gov Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28583 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Track listing Putan Club – Phénix Zoo – AWI (Discover) Unknown artists – Kecak: The Ramayana Monkey Chant (excerpt) Avalanche Kaito – Lago Blockhead & Quelle Chris – The Cella Dwellas Knew Dingus Khan – Japanese Fighting Bugs Grace Denton – Trouble (After Yusuf) The James Worst Public Address Method – The Great Silence Squarepusher – Wendorlan maarja nuut & ruum - Haned Kadunud Meara O'Reilly – II Chrisman – Christoven feat. Papalas – Body & Blood Mob – VAG Pound Land – Pistol Shrimp Dingus Khan – Ivan Ooze Aesop Rock – Crows 1 (with Kimya Dawson) Circolo Vizioso – Verrueckt Sonic Youth – The Word (E.V.O.L.) Milkweed – Stallion Fights bell lungs – Lamplight Masal – Dokuz The Smile – Teleharmonic Dingus Khan – Keel Over
Interview with Roni Shouval, MD, PhD, author of T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy. Hosted by Vivek Subbiah, MD. Related Content: T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy
Interview with Roni Shouval, MD, PhD, author of T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy. Hosted by Vivek Subbiah, MD. Related Content: T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy
“Neuroinflammation causes neuronal dysfunction by destabilizing excitatory synapses” and “Antigen-specific T cells in autoimmune inflammatory diseases of the central nervous system” The Anne Klibanski Visiting Lecture Series was created to support and advance the careers of women. These lectures bring together faculty from institutions that have hosted Anne Klibanski Scholars with MGH scholars, on topics that overlap both research areas. Dr. Gillani presented on “Neuroinflammation causes neuronal dysfunction by destabilizing excitatory synapses.” Dr. Hastermann presented on “Antigen-specific T cells in autoimmune inflammatory diseases of the central nervous system.” Presenters: Rebecca L. Gillani, MD, PhD, Instructor, Neurology, MGH/HMS Maria Hastermann, MD, PhD, Max Delbrück Center, Berlin Learning Objectives for Dr. Gillani's talk: Upon completion of this activity, participants were able to: Understand the contribution of neuronal dysfunction to neurologic disability in people living with multiple sclerosis. Recognize the scope of synaptic dysfunction in people living with multiple sclerosis. Identify potential mechanisms for neuronal dysfunction due to neuroinflammation. Learning Objectives for Dr. Hastermann' talk: Upon completion of this activity, participants were able to: Describe neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Recognize the role of T cells in central nervous system (CNS) inflammation. Review the longitudinal prospective registry study (example BERLimmun). Click here to watch webinar.
What do we really know? What do you really know? What makes your facts true versus some other person's facts? What kind of questions are those? Does it matter? Do we matter? Uh-oh! The questions come with weight. They come with an openness that isn't comfortable. Should WPI take a mental health moment/day/period? How hard is hard now a days? Content, context, and definition. These are the keys, the jewels, and the absolute must be understood and agreed upon marks. Confusion only exist because one doesn't know and/or one hasn't shared. Humanity, stop it! It's time to be what we actually are and should be. Opportunity over everything. Duplicate Antigen Dose. Take it! Take it again! Just get and use the cure. It's way past time. Have as many regrets as necessary. Just do what needs to be done. Here we go! Welcome in........ In this episode of We Play It Adui Yako (AY the wise nose bandit) and BK (The Subverted Connector- The Wonder Twin Defector- The Milk of Magnesium Ingestor- The Mid Day Tube Socks on Professor- The Capt'n w/no T'Neal Sailor) groove into solars and eclipses and anything unreal enough to make the believable seem para-actual. They are very tuff with it.... That was your one and only written warning. Know that you seen it. No fine print. Real size and really visible. Go on. The fellaz are ready. The material is ready. The sound is ready. The moment is ready.... You already know how they do it. You know why they do it. And they are going to continue to do it as long as they have breath. As long as there is sound. As long as there is melody. As long as someone somewhere says or does something with an instrument or something that makes some kind of musical note, pattern, and/or creation.... This is WPI. We welcome you and we sincerely thank you! Feast away with this episode of ear candy..... Featured Tracks:Cola- So Excited Spotlights- The Alchemist The Friends of Distinction- And I Love Him Psychi- velvet LOS KEMET- Most Civilized Spirit Yumeia, Tre Flip- stanza senza luce The Beatles- I'm Only Sleeping Hit-Boy, The Alchemist- MORRISSEY STPH So Low- HANDPRINT Suzy Clue- Remember Me Jay Dee, J Dilla- Shake It Down Ahk Sair, KINAYDUH- No Te Rompas Spotify Playlist "WPI 2024_103" WPI - WePlayIt Recorded 3-26-24 #wpi #weplayit PARENTAL ADVISORY
Track list: Godspeed You! Black Emperor – The Dead Flag Blues (Intro) George Spangler and Congregation of Thornton Old Regular Baptist Church – Guide Me, O Thou Great Jehovah Genius / GZA – 4th Chamber (feat. Killah Priest, RZA & Ghostface Killah) Grove – Fuck Ur Landlord Goblin – Sighs Gary Numan – M.E. Ghost – Dominoes - Celebration for the Gray Days Georgian Voices – Tamar kalo, kveqnis tvalo Group Inerane – Kuni Majagani Ghostface Killah – Daytona 500 Grinderman – No Pussy Blues Ghédalia Tazartès – Rien qu'au soleil The Golden Gate Quartet – Hush! Gang of Four – I Found That Essence Rare Glenn Branca – The Spectacular Commodity Grandmaster and Melle Mel – White Lines (Don't Don't Do It) Grupo de Capoeira Angola Pelourinho – Ladainha: King Zumbi of Palmares God – My Pal Group Bombino – Amidinine Gary Davis – I Am the True Vine Gavin Friday and the Man Seezer – Next Guided By Voices – Games of Pricks Gaffa Tape Sandy – Beehive
The PSA is a blood test to screen for prostate cancer. What does this testing process look like? Listen to learn more.
In this episode, we review the high-yield topic of Antigen-Antibody Interactions from the Immunology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
After a decade of cuts, a new photograph of the king brings hope to public sector workers in the UK, prompting Jason to reflect on the role of the monarchy in 21st century Britain. Can Prince Andrew teach us the true meaning of friendship? Does the king really think dolphins are fish? And will a last-minute celebrity intervention save support for care leavers in Suffolk? Enter the realm of twilight to find out. Plus, Xolile Madinda tells us why he contributed to Cease Silence, a new album of music by artists opposed to Israel's military action in Gaza. Trigger warning: this show contains material about the royal family that may upset survivors of abuse. Dead Rat Orchestra – Oh Rue the Day Italian Books – Your Least Favourite Leech (My Favourite Parasite remix by DShappyBOI) Rev Simpkins and Jim Simpkins – Headwater Fever Ray – Shiver Dorian Wood – Arayes Sutari – Zawołanie Sage Francis – Master Cleanse (feat. Oldboy Rhymes, Rituals of Mine and Alxndrbrwn) The Pop Group – We Are All Prostitutes Defboyz – Land Reform (feat. Radical) The Legless Crabs – Annihilator Wamkelwa Nkone – Thokoza
Food for thoughts. Tesseract Psychedelic 60's How to be a human being Same curfew, It's too late to surf Stay to talk End up getting later, That's paperwork I graduated I finally made it I'm one of the greatest Passed in the test It was graded I passed Glad you asked, Actually, Task rabbit Ya past habit of Rambling has I'm already famous Synonyms for the simpletons Sentiments and cinnamints Antigens on intimite Indegenous considerations Reprarations is Dangerous to say Thanks to your Mother Nature sir I give em cinnamon for breakfast Thenbportal off into the sunset Like damn Scoot back I got a new password I'm at an award show Been looking fabulous Shit is bananas You been in Alaska Damn Like fuck that Got a new truck though Four by four And it was runs on water I got a portal gun. You been in Alaska How's that? Don't ask Don't dance— Unless you ask, handsome I don't feel safe anymore! I won a Grammy award! S I'm in the back of hearse— But I'm still whipping out verses He's swerving Sirens on And I'm informing him I want him Stuff your oven with my muffin If you love the sound of the trumpet — I told him Then I portal gun into the sunset Then I portal gun into the sunset Then I portal gun into the sunset Do you want this? I'm already famous; Do you know what my name is? Can I get on your playlist? I made it What did you say? So many colors could throw a parade Do you know l could open up for a whole stadium? What are you made of? Don't say my name if it ain't love Jump in a portal I got a portal gun I got sombreros and sunhats For your summer Stunner shades and Even hades would hate us In these heat waves Wave hey to the naysayers From high on parade throats And cut they throats If they throw shad No umbrella This ain't no ordinary fella This is a Clever Peter Pan in Nevereverland You understand from Wonderland Atlanta to Africa Portal I got a new password I'm not to look back on the assholes This shitbis banaas, You gotta move backwards Sometimes I just got an award Off of strawberries Not very star struck no more When im on TMZ u see me Gossiping I'm not sorry When you wish on a star You wish for me When you call for mom I'm not coming Cause I'm father, Now wash and park my car While I walk out in sparkles Who are you? I won an award So I'm at the award show Don't be startled And don't start a war With Mother Earth You're on her Right on time The price is right is on you You want a codeword, Go try “alarm clock” That's why we don't talk Go stalk some other Anonymous immortal Portal Gun off in the sunset I wanna work [The Festival Project.™] COPYRIGHT © THE FESTIVAL PROJECT 2024 ALL RIGHTS RESERVED. © -Ū.
In this week's episode we'll discuss the findings from a prospective trial of brentuximab vedotin with dacarbazine or nivolumab in older patients with classical Hodgkin lymphoma, learn more about CD20 antigen loss as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas, and discuss the role of trogocytosis in red blood cell antigen loss.
What is wrong with seaside people? Why do Brexit rebels love Spartans? And who needs art, when you have turnips? Jason defends the philistines of Suffolk against the theatre-peddling menace of Judi Dench and Stewart Lee. He plunges the bowl to flush out the PopCon movement and investigates their claim that Britain is full of secret Conservatives. Plus Fox in the dock and Farage on the hunt. Track listing: Antony and The Johnsons – River of Sorrow Armand Hammer – The God's Must Be Crazy PJ Harvey – Kamikaze (demo) Blind Willie Johnson – The Soul of a Man Butthole Surfers – American Woman Pissabed Prophet – Hornet Marc Newby – Dead Weight The Magnetic Fields – A Chicken with Its Head Cut Off Kulk – Day Old Kebab Paavoharju – Sä Olit Pound Land – Programmed
In this episode, Dr. Stephanie interviews her close friend and Naturopathic Doctor, Dr. Nick Baboulas. Formerly a Medicinal Chemist leading the charge in pharmaceutical discovery, Dr. Nick's life took an unexpected turn when his sister fell ill. This is when he knew he needed a career change. Deciding between conventional medical school and naturopathic medicine, he embraced the latter, forever changing the trajectory of his career.Grab your headphones or turn the volume up and get ready to unravel the mysteries of Low Dose Immuno or Antigen Therapy, popularly known as LDIs and LDAs. Dr. Stephanie and Dr. Nick, plunge into the depths of this cutting-edge therapy, exploring its applications, methodologies, and the myriad of conditions that stand to gain from its unique approach.They bring their combined expertise to the forefront, offering a comprehensive understanding of this hot topic, including analogies that really make sense and provide a better understanding of how your immune system works. With a wealth of knowledge and personal experiences, they navigate through the complexities of this therapy, providing listeners with a nuanced perspective on its applications.Whether you're a seasoned health enthusiast or just diving into the world of alternative treatments, Dr. Stephanie and Dr. Nick are here to guide you through the fascinating realm of LDIs and LDAs, showcasing the potential of this groundbreaking therapy for various health conditions.More about Dr. Nick: Dr. Baboulas first career was as a “Medicinal Chemist' working in the Pharmaceutical Industry, however, personal family circumstances changed his career path and he went to Naturopathic Medical School to become a Naturopathic Doctor.Dr. Baboulas experiences have shaped his way/philosophy on how to view disease/illness and the patient; therefore, he tries to understand the patient's current pathological state from a Bioregulatory/ Integrative Biological Medicine standpoint. He has done extensive training in many disciplines around North America and Europe with world-renowned Doctors in their respective fields, and very lucky to be able to call some of them his mentors!Dr. Baboulas' style is eclectic, where he utilizes whatever modalities best fit his patient's condition/current state. Clinically, he focuses on supporting patients with complex chronic illness, such as autoimmune disease, Lyme, Mold Illness, CFS, Fibromyalgia, etc. He knows that there is hope, patients can reach their optimal health, and he is thereto support them along that healing journey.To get in touch with Dr. Nick please check out his website here and his Instagram account here. And to contact him directly please email info@eirinihealingsolutions.ca.Follow Dr. Stephanie on Instagram here.Follow Dr. Stephanie's Functional Medicine Clinic - Vagus Clinic here.For more resources and how to work with Vagus Clinic - check out the website here.
Capitalism would have you believe that hard work is the only requirement for success. If you work hard, you reap the reward. If that's the case, why are performance reviews so chaotic ... after all, you did put in the hard work! The Access Point hosts Drs. Lonnie & Wendy welcome special guest Rasháanda Cook to discuss further. Discussion Insight: What is meritocracy? What are the conditions that make it work as described? Why do performance evaluations such so much? What are the biases in performance reviews that we need to look out for as Black and brown folk at work? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Rasháanda on LinkedIn. https://www.linkedin.com/in/rashaandacook/ Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
Dr. Juan Vera, CEO of Marker Therapeutics, a clinical-stage immuno-oncology company, is developing next-generation immunotherapy with a multi-tumor-specific T-cell platform to overcome limitations of current T-cell therapies with narrow target recognition. This approach, which recognizes multiple antigens within the tumor, helps prevent tumor resistance and adaptation. Marker is participating in the APOLLO trial testing this broad spectrum of target recognition in lymphoma patients who have relapsed after CAR-T CD19 therapy while also exploring acute myeloid leukemia and pancreatic cancer. Juan explains, "Without a doubt, the earlier products that have been approved, such as mainly chimeric T-cell receptors, have validated the clinical power of T-cells in their ability to recognize and kill cancer cells. I think that no one will argue that, and this has been something that has been well evaluated, particularly in hematologic malignancies and particularly in lymphoma." "However, there are limitations with these types of technologies, and some of the limitations now have become more and more obvious a few years after the approval of those initial drugs. One of the main limitations relies on the short-term clinical benefit observed in many cases once patients receive these therapies. That can be attributed largely to the narrow target recognition of these initial strategies." "Our approach is different and seeks to overcome this particular limitation. The way that we seek to do so is by creating a product that is capable of recognizing multiple antigens present within the tumor. In that particular way, our therapy is capable of preventing this mechanism of tumor adaptation and tumor resistance. We hope that this multi-target approach will lead to clinical responses that will be long-sustained and durable in comparison to what we're seeing initially with these initial studies or initial drugs that have been approved in the market." #MarkerTherapeutics #Oncology #AutologousCellTherapy #TCellTherapy #Lymphoma #Cancer markertherapeutics.com Download the transcript here
Dr. Juan Vera, CEO of Marker Therapeutics, a clinical-stage immuno-oncology company, is developing next-generation immunotherapy with a multi-tumor-specific T-cell platform to overcome limitations of current T-cell therapies with narrow target recognition. This approach, which recognizes multiple antigens within the tumor, helps prevent tumor resistance and adaptation. Marker is participating in the APOLLO trial testing this broad spectrum of target recognition in lymphoma patients who have relapsed after CAR-T CD19 therapy while also exploring acute myeloid leukemia and pancreatic cancer. Juan explains, "Without a doubt, the earlier products that have been approved, such as mainly chimeric T-cell receptors, have validated the clinical power of T-cells in their ability to recognize and kill cancer cells. I think that no one will argue that, and this has been something that has been well evaluated, particularly in hematologic malignancies and particularly in lymphoma." "However, there are limitations with these types of technologies, and some of the limitations now have become more and more obvious a few years after the approval of those initial drugs. One of the main limitations relies on the short-term clinical benefit observed in many cases once patients receive these therapies. That can be attributed largely to the narrow target recognition of these initial strategies." "Our approach is different and seeks to overcome this particular limitation. The way that we seek to do so is by creating a product that is capable of recognizing multiple antigens present within the tumor. In that particular way, our therapy is capable of preventing this mechanism of tumor adaptation and tumor resistance. We hope that this multi-target approach will lead to clinical responses that will be long-sustained and durable in comparison to what we're seeing initially with these initial studies or initial drugs that have been approved in the market." #MarkerTherapeutics #Oncology #AutologousCellTherapy #TCellTherapy #Lymphoma #Cancer markertherapeutics.com Listen to the podcast here
References Cancers 2020, 12(4),952 JBC. 2018. 293: 2422-2437. J Immunother Cancer. 2021 Nov;9(11):e003675 Front Oncol. 2023 May 18:13:1145667 Front. Immunol.2019. Sec. Cancer Immunity and Immunotherapy Volume 10 Int. J. Mol. Sci. 2019, 20(3), 646 Front Immunol. 2019; 10: 14 Vivaldi, A. 1716. RV589 Gloria https://youtu.be/2eWjQOdYzMQ?si=dpZaNZilqPXi6fJU --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
References Front Immunol. 2019; 10: 14 Cancer Immunol Immunother. 2016 Apr;65(4):441-52 Anal Cell Pathol (Amst).2018; 2018: 787.1814. Molecular Cancer 2020. volume 19, Article number: 39 Cohan, G. 1917. "Over There" https://youtu.be/BYV044H5muI?si=LdANMG6dtXeC14tj --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Workplace communication, particularly around expectation setting and feedback with supervisors, can be riddled with anxiety. Many people are not good at these interactions and can easily slip into a myriad of manipulation and gaslighting tactics to get their way. If you are not careful, you might be left carrying a bag that is not actually for you. The Access Point hosts Drs. Lonnie & Wendy welcome special guest Deborah Owens to discuss further. Discussion Insights: How to spot manipulation, gaslighting and other coercive communications techniques used at work? How should Black/brown professionals appropriately take control of tense workplace interactions? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Deborah on LinkedIn. https://www.linkedin.com/in/deborahtowens/ Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
While diversity and representation continue is additive to business strategy, many organizations still struggle to recruit, reward, and retain a diverse workforce. While we'd expect the most senior Black/brown people in the workplace to serve as a built-in mentor, coach or advocate, that is not always the case. It's even worse when it feels like they actively undermine you. The Access Point hosts Drs. Lonnie & Wendy welcome special guest Dr. Brenda Carter to discuss further. Discussion Insights: What is gatekeeping? What does this mean in the workplace? What is the long term effect of not dealing with gatekeeping - overt and covert? What do we want to see in people who control access to power, information, opportunity, and resources? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Dr. Carter on LinkedIn. https://bit.ly/3tLshlw Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
As society continues to settle into realigned relationships with work, a big aspect of this post-pandemic reality has been better alignment with personal values and then establishing and enforcing boundaries to honor these values. As a result, sometimes the answer to a reasonable workplace is "No". Drs. Lonnie & Wendy welcome special guest Dr. Candice Hunter to discuss further. Discussion Insights: What are boundaries? Where should Black/brown folks exercise caution in response to other people's boundaries (or them telling us no)? How can we say ‘no' without saying ‘no'? How do we manage the side effects of 'no' and boundaries? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Dr. Hunter on LinkedIn. https://bit.ly/3M7IeZB Check out Fluency Management's website. https://bit.ly/3Foo89C Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
References Brain. 2023 Sep 13:awad309 McBroom, Amanda. 1970 "the Rose" httBps://youtu.be/cO59ITNCxzk?si=v-qx_2_mPq3zbCYH --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
The work experience can be especially magical, when the work is so intertwined to your life's purpose and your reason for being. Drs. Lonnie & Wendy welcome special guest Dr. Ayanna Lynch to discuss how to ensure your well stays full, even as you pour into others. Discussion Insights: In an utopian world, we would all have a job that fits perfectly with our purpose. If you aren't one of the lucky ones - how do we jumpstart that right now? Sometimes the nature of the work can make it challenging to connect with purpose on your own. Sometimes it takes a communal effort. How can we do this together? Can connecting to your purpose via work (in some form) mitigate the mental health crisis facing our workforce? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Dr. Lynch on LinkedIn. https://bit.ly/3PUqBgL Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
References Mozart, WA. 1791. Clarinet Concerto in A major, K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5 Small GTPases. 2014; 5: e28579 Acta Neuropathol. 2023; 145(6): 749–772 J Immunol. 2000 May 15;164(10):4991-5 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
If culture is loosely defined as the way things get done, how might racial and ethnic cultural norms impact how Black and brown folks show up in work spaces, that historically were not designed to include them? Drs. Lonnie & Wendy welcome special guest Jason William Johnson to talk about the history, impact, and reach of Black culture and showing up at work "for the culture"! Discussion Insights: How does hip hop culture support our wellbeing in the workplace? When we think about work, how else is hip hop underutilized? How do we leverage the threads of social justice in hip hop culture for organizational justice? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Jason on LinkedIn. https://www.linkedin.com/in/jasonwilliamjohnson/ Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
For Black and brown professionals, work can be the polarizing experience where you can be celebrated for representing the 'underrepresented', while simultaneously being shunned and silenced for your representation. Drs. Lonnie & Wendy welcome special guest Dr. Rashida Govan to talk about how to stand in the fullness of your "Black power" while at work. Discussion Insights: What does it mean to advocate for self at work? What happens at the intersection of self-advocacy and activism? How do we navigate the advocacy vs. professionalism debacle? Connect with Dr. Edmonds & Dr. Morris on LinkedIn. Links in order: https://bit.ly/3B3uhqs http://bit.ly/3XrJKcZ Connect with Dr. Govan on LinkedIn. https://bit.ly/454kOep Review the discussion notes, questions, and takeaways on Flipboard. https://bit.ly/3WgXpDC Listen to Pfizer's "The Antigen" podcast today. https://bit.ly/3EIIUQD Listen to Pfizer's "Science Will Win" podcast today. http://bit.ly/3u3uoxW
The Best Natural Ways To Address Skin And Histamine Issues - Live Podcast | Podcast #390 Schedule a FREE Consult: http://www.justinhealth.com/free-consultation Podcast Transcription: Coming soon... Products: Ketomojo blood sugar meter: http://www.justinhealth.com/ketomojo Headsup Health free sign up: http://www.justinhealth.com/headsup Timestamp: 01:48 - Topical Remedies 03:19 - Histamine - Gut Connection 05:13 - Molds, Antigens and Anti-Histamine 09:45 - Low Stomach Acidity 10:49 - Other Symptoms 13:55 - Functional Medicine Remedy Approach 16:31 - Mold Toxicity 21:57 - Adrenals Description: In this week's episode, we delve into the fascinating world of skin and histamine from a functional medicine perspective. We begin by exploring the skin's multifaceted role as a barrier, a detoxification organ, and a direct reflection of our internal health. Then we shift to the topic of histamine, a crucial immune system messenger, often misunderstood and overlooked, that can significantly impact our skin and overall health when imbalanced. Our guest expert, a renowned functional medicine practitioner, shares insights into histamine intolerance, discussing its often overlooked relationship with conditions like eczema, hives, and psoriasis. Additionally, we touch on how diet, gut health, and genetics can influence histamine levels, and consequently, skin health. Finally, we wrap up by exploring holistic strategies to balance histamine levels, fostering not just healthier skin, but improved overall wellness. ===================================== Click here for Dr. J's links: https://www.justinhealth.com/links ===================================== ***Click below to SUBSCRIBE for more Videos http://www.youtube.com/subscription_center?add_user=justinhealth =====================================