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1. Patient-reported outcomes across cerebrovascular event types - more similar than different 2. [What’s Trending]: Genetic landscape of pediatric movement disorders and management implications.In the first segment, Dr. Andrew Southerland talks with Dr. Irene Katzan about her paper on patient-reported outcomes across cerebrovascular event types. In the second part of the podcast, Dr. Jeff Waugh focuses his interview with Dr. Saadet Andrews on the genetic landscape of pediatric movement disorders and management implications. DISCLOSURES: Dr. Southerland has severed on editorial boards for the Journal Neurology and is Section Editor for the Neurology Podcast. Dr. Katzan served on editorial boards for Stroke (American Stroke Association) and Circulation: Cardiovascular Quality & Outcomes (American Heart Association). Dr. Katzan has received funding for research support from Novartis Pharmaceuticals and research support from the Ohio Department of Health - Physician Lead for the Ohio Paul Coverdell Stroke Registry, 2007-2020. Dr. Waugh was employed by Children's Hospital Boston, Resident in Pediatric Neurology, 2009-2015. Dr.Saadet Andrews served on a scientific advisory board for non-profit data safety board member for a research study at The Hospital for Sick Children (2015-2017), a Commercial: Epileptic encephalopathy scientific board meeting attended in December 2017, organized by BioMarin, and a Commercial: Advisor cost effectiveness of ERT (March 2018) Commercial: Advisory board and speaker for homocysteine and betaine treatment (December 2017). Dr. Andrews received funding for travel from BioMarin (Epileptic encephalopathy scientific board meeting attended as invited speaker in December 2017) and was paid honorarium and travel-expenses. Dr. Andrews served on editorial boards for Non-profit: Journal of Pediatric Genetics Editorial Board Member (2015-present) and received research support from industry funding (2015-2016) for prevalence of mucopolysaccharidosis if rheumatology and NCV patients.
This week we speak with Dr. Douglas Mah, Assistant Professor of Pediatrics - Harvard Medical School and Director of the Pacemaker and ICD Service at Children's Hospital Boston about a recent paper he published with his colleagues on coronary artery compression from epicardial pacemaker leads. Who is at risk for this rare complication? How can patients be screened? Once identified, what is the treatment? We review all this and more with Dr. Mah. doi: 10.1016/j.hrthm.2018.06.038
Dr. Jake Kushner is leading the efforts in Diabetes and Endocrinology at Texas Children's Hospital. Dr. Kushner is a McNair Medical Institute Scholar at the Baylor College of Medicine. As the Chief of Pediatric Diabetes and Endocrinology at Baylor College of Medicine, he is a major thought leader in type 1 diabetes care and research. His overarching career goal is to help children and young adults with diabetes and other endocrine disorders live long, healthy lives. His administrative priorities focus upon developing and promoting innovative new models of patient-centered care, education, and cutting edge research. A graduate of the University of California at Berkeley, Dr. Kushner earned his medical doctorate from Albany Medical College in New York. He completed a residency in pediatrics at Brown University. He then completed a clinical fellowship in Pediatric Endocrinology at Children's Hospital Boston, Harvard Medical School, followed by a 5-year research fellowship at the Joslin Diabetes Center at Harvard Medical School. Prior to arriving at the Baylor College of Medicine Dr. Kushner was at the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia (CHOP). Dr. Kushner has received national awards, including elected membership to the prestigious American Society of Clinical Investigation. He currently serves as the president of the Society for Pediatric Research. Dr. Kushner's research has been supported by the National Institutes of Health, the Juvenile Diabetes Research Foundation and the March of Dimes, amongst other sources. His clinical interests include the care of children with type 1 diabetes. Dr. Kushner's research is focused upon of the insulin-secreting beta cells of the pancreas. A major theme of the Kushner lab includes studies to understand the origins of adult beta cell growth and regeneration. Until recently it was not clear exactly where adult beta cells came from during postnatal life. Dr. Kushner and colleagues have carried out studies in adult mice with a variety of advanced tools. In contrast to the dominant views, they do not observe any contribution to beta cell growth in adult mice from "tissue stem cells". Instead, they find that beta cells expand by simple division "self-renewal". Dr. Kushner and colleagues are currently extending this work, with the goal of studying beta cell regeneration under a variety of normal and disease conditions. In This Episode We Discuss: The intricacies of type 1 diabetes Beta cell dysfunction Nutritional approaches to type 1 diabetes: standard care and carbohydrate restriction Issues with low-carb for T1D: hypoglycaemic episodes? ketones? long-term safety unknown? "Low carb is not for everyone with T1D. Frankly, there is so much that we don’t know. But, low carb management of T1D can be quite advantageous for those who choose it." - Jake Kushner, MD
Addicted to technology? Dr. Michael Rich, Pediatrician in Adolescent Medicine at Children's Hospital Boston, and Director of the Center on Media and Child Health, and Matt Richtel, a Pulitzer Prize-winning technology reporter for the New York Times, and the author of "A Deadly Wandering" join us to talk about the effects of technology on our brains, and how to balance screen time for ourselves and our children.
JNIS editor Rob Tarr talks to Darren Orbach, Department of Neurointerventional Radiology, Children's Hospital Boston, about his recent editor's choice paper: Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformation.
Dr. Judith Palfrey is a professor of pediatrics at Harvard Medical School and director of the Children's International Pediatric Center at Children's Hospital Boston. Dr. Sean Palfrey is a professor of pediatrics and public health at Boston University School of Medicine and a practicing pediatrician at Boston Medical Center. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. J.S. Palfrey and S. Palfrey. Preventing Gun Deaths in Children. N Engl J Med 2013;368:401-3.
HMS Instructor of Radiology Phoebe Freer explains the benefits of tomosynthesis, an imaging tool developed at Massachusetts General Hospital to enhance breast cancer screening. During a tomosynthesis exam, a camera moves in an arc over the patient, taking a series of low-dose images, which get stitched together by software. Radiologists use the resulting 3D compilation to find tumors that might be hiding and scrutinize potential problem areas before worrying patients. This podcast also explores 3D tissue models developed in the Brugge laboratory to study cancer. Plus, Professor of Radiology Tina Young Poussaint at Children's Hospital Boston shares her perspective.
Dr. Robert Truog is a professor of medical ethics, anesthesiology, and pediatrics at Harvard Medical School and a senior associate in critical care medicine at Children's Hospital Boston. Stephen Morrissey, the interviewer, is the Managing Editor of the Journal. R.D. Truog. 200th Anniversary Article: Patients and Doctors - The Evolution of a Relationship. N Engl J Med 2012;366:581-5.
Dr. Anselm is a member of MitoAction's medical advisory committee and practices in Child Neurology at Children's Hospital Boston. Her research is focused on clinical presentation of children with mitochondrial disorders and their response to therapy.
In this episode I speak about managing anaphylactic food allergies using the desensitisation method. There is a current study going on in the Children's Hospital Boston using a desensitisation method, which sort of mirrors the treatment that's been going on for years over at the Pediatric Hospital Burlo Garofolo in the city of Trieste, north-east of Italy (www.burlo.trieste.it) Listen to the podcast here first, then read the websites / watch the videos below. Here's the website for the Italy based treatment - http://www.allergyhope.com Here's the website explaining the USA based treatment and introducing Brett - http://childrenshospitalblog.org/a-cure-for-milk-allergies Watch the 2nd one here which explains the treatment - http://childrenshospitalblog.org/a-cure-for-milk-allergies-dr-schneider-explains-the-bold-new-idea/ Then the 3rd one with Brett having his first sip of milk - http://childrenshospitalblog.org/a-cure-for-allergies-part-3-brett-nasuti-takes-his-very-first-sip-of-milk/ The rest you can watch over at Children's Hospital Blog, but these were the main ones I wanted you to see. Talk soon Aaron
Robert D. Truog, MD, MA, discusses new guidelines published in the March 2008 issue of Critical Care Medicine, "Recommendations for End-of-Life Care in the ICU." Dr. Truog is professor of medical ethics and anesthesia (pediatrics) at Harvard Medical School and senior associate in critical care medicine at Children's Hospital Boston in Massachusetts. (Crit Care Med. 2008;36:953-963)
Peter C. Laussen, MD, discusses an article published in the May 2007 issue of Pediatric Critical Care Medicine, titled "Pediatric Staff Perspectives on Organ Donation After Cardiac Death in Children." Dr. Laussen is director of the cardiac intensive care unit at Children's Hospital Boston. This is the first podcast in a two-part interview. Part two will feature an interview with lead author Martha A.Q. Curley, RN, PhD. (Ped. Crit. Care Med. 2007;8[3]:212).
Robert Truog, MD, FCCM, discusses his article published in the December 2005 issue of Critical Connections, "Pediatric End of Life: Special Needs for Special Children." Dr. Truog is professor of medical ethics and anesthesia, pediatrics at Harvard Medical School, Children's Hospital Boston. He discusses the unique challenges faced in the pediatric intensive care unit by physicians and family members. (Crit Conn 2005 Vol.4 No.6)