Podcasts about philadelphia chop

"Certainly, I've been anxious about data...I did an experiment, I put a lot of time into it, I'm hoping to get good results...we all know that feeling, right? The stakes are just so different here...this kid's life depends on whether this experiment worked." --Kiran Musunuru, MD, PhD One of the highlights of the ASGCT 28th Annual Meeting was the announcement on May 15 of a historic medical breakthrough: a child diagnosed with a rare genetic disorder had been successfully treated for the first time with a customized CRISPR gene editing therapy. The infant, KJ Muldoon, was born with a rare metabolic disease called severe carbamoyl phosphate synthetase 1 (CPS1) deficiency. When he was just six months old, KJ received his personalized therapy at the Children's Hospital of Philadelphia (CHOP), where ASGCT Members Kiran Musunuru, MD, PhD; and Rebecca Ahrens-Nicklas, MD, PhD; led the group of researchers who developed KJ's treatment. KJ is now growing and thriving. He recently left the hospital where he has spent the majority of his life. And the day after presenting the research that led to this first-of-its-kind development, Dr. Musunuru told us that there was so much more to the story. Listen to our first episode of Soundbites of the Annual Meeting with Dr. Kiran Musunuru. Did you attend the 28th Annual Meeting? Watch all sessions, including Dr. Musunuru's presentation, on demand on the virtual meeting platform through July 18! Not a member? Join now and receive 19 months of membership for the price of 12. Show your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

One of the biggest stressors for parents is helping their child get to sleep and stay asleep. Bedtime can be a real battle for parents at times and today's guest is here to help alleviate that by looking for root causes and also how you parents can help relieve your sleep issues as well. When the whole family sleeps well, things go better.   In this episode, she'll talk about sleep apnea - yes, even for kids - which includes snoring, and mouthbreathing, and how sleep is not a "passive process" like we might think, involving hormones, the immune system and even memories that are processed while we sleep.  Our sleep is affected by nutrition such as iron deficiencies and our sleep hygiene like how dark, cool and noise-free the room is for sleeping.  And one that parents are certainly guilty of - screentime before bed. Dr. Brown says we need to stop that at least 60 minutes before bed and that includes TV and tablets too.  Dr. Funke Afolabi-Brown is a board-certified pediatrician with extensive experience working with children who suffer from a range of sleep issues, including insomnia, sleep apnea, and behavioral sleep disorders. Her holistic and compassionate approach to care sets her apart as a trusted expert in her field. Dr. Afolabi-Brown earned her medical degree from the University of Ibadan, Nigeria, one of Africa's premier institutions for medical education. She completed her pediatrics residency at the Children's Hospital of Philadelphia (CHOP), which is renowned globally for its cutting-edge pediatric care and training programs. Subsequently, she pursued a fellowship in sleep medicine at the University of Pennsylvania, where she gained specialized expertise in diagnosing and treating sleep disorders in children. I know you're going to get a ton of great value out of this episode so please enjoy the show. Beyond her clinical work, Dr. Afolabi-Brown is an advocate for sleep health education. She actively raises awareness about the importance of sleep through various platforms, including community outreach, public speaking engagements, and digital media. Her mission is to empower parents and caregivers with the knowledge and tools they need to create healthy sleep habits for their children. Dr. Afolabi-Brown is also active in several medical associations, including the American Academy of Sleep Medicine (AASM), the American Academy of Pediatrics (AAP), and the Society of Behavioral Sleep Medicine. Her contributions to these organizations include advancing research, developing best practices, and sharing insights on sleep interventions. She has also collaborated on scholarly publications and presented at national and international conferences, demonstrating her commitment to the growth and development of her field. Find Dr. Brown here: Her book: https://beyondtiredbook.com/  Website  https://www.therestfulsleepplace.com/ Instagram: https://www.instagram.com/restfulsleepmd/ Facebook: https://www.facebook.com/restfulsleepmd/ LinkedIn: https://www.linkedin.com/in/drfunkebrown/ YouTube: https://www.youtube.com/channel/UCPateezmNmJ_Vrtizii5q-A   Please listen and subscribe to our podcast and leave a 5-star review or thumbs up so we can reach more parents like you! Subscribe to our podcast by sending an email to subscribe@teachingyourtoddler.com For more expert interviews, fun activities and story time podcasts, please visit our website at https://www.teachingyourtoddler.com/ All our shows are posted as videos as well on our YouTube channel here: https://www.youtube.com/@MarijoTinlin Find us on social media here: Facebook at https://www.facebook.com/TeachingYourToddler X/twitter at https://x.com/TeachingToddler Instagram at https://www.instagram.com/teachingyourtoddler/ To support great future content, please click here and help us out with a $5 gift: glow.fm/teachingyourtoddler Leave us a 5-star Review and comment your ideas for future shows! #parenting #toddlers #moms #momlife #kids #podcast #toddlerlife #education

S2E5: Host Don Hardwick discusses the complexities of release of information with Fabian Stone, the Vice President, Revenue Cycle Operations at Children's Hospital of Philadelphia (CHOP). Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen/

In a special co-branded episode between Oncology On theGo hosted by CancerNetwork® and the American Society for Transplantation and Cellular Therapy (ASTCT)'s program ASTCT Talks, Nora M. Gibson, MD, MSCE, and Taha Al-Juhaishi, MD, spoke about real-world applications of betibeglogene autotemcel (beti-cel; Zynteglo) as a treatment for patients with beta (β)-thalassemia.They spoke in the context of a study that Gibson presented at the 2025 Tandem Meetings, which evaluated patients who received commercial beti-cel in a single-center cohort following the agent's FDA approval in August 2022. ¹ ²Nora is a fourth-year fellow in bone marrow transplant andcellular therapy at the Children's Hospital of Philadelphia (CHOP), with a background in clinical research and epidemiology. Al-Juhaishi is the Associate Director of the Hematopoietic Stem Cell Transplantation and Cell TherapyProgram at Oklahoma University Health Stephenson Cancer Center and an assistant professor of Medicine at the University of Oklahoma College of Medicine.Findings from Gibson's study revealed that among 10 patients who underwent stem cell collection at CHOP from 2022 to 2024, beti-cel yielded consistent red blood cell transfusion independence, with investigators notingprolonged platelet engraftment time and high platelet transfusion requirements. Beyond these findings, the conversation focused on how beti-cel compares withother currently available gene therapies for patients with hemoglobin disorders as well as non-curative therapies like allogeneic stem cell transplantation. Gibson and Al-Juhaishi also discussed strategies for mitigating occlusive disease and other potential toxicities associated with beti-cel.“It's a really exciting time to be working in this fieldwhere we finally have really good options for these patients. From our experience and from clinical trials, beti-cel and likely exagamglogene autotemcel [Casgevy]...are very effective, curative therapies for thalassemia in the real-world setting, and we've seen very similar results in sickle celldisease,” said Gibson. “These therapies have been really life-changing for our patients, and they've had a huge reduction in their symptoms and a huge reduction in their burden of health care that's required.”References1.     Gibson NM, Friedman DF, Elgarten CW, et al. Post-approval, real-world experience with betibeglogene autotemcel for transfusion-dependent betathalassemia. Transplantation and Cellular Therapy. 2025;31(2):S254. doi:10.1016/j.jtct.2025.01.386.2.     FDA approves first cell-based gene therapy totreat adult and pediatric patients with beta-thalassemia who require regular blood transfusions. News Release. FDA. August 17, 2022. Accessed April 21, 2025.https://tinyurl.com/3vrkk8kz

In a special co-branded episode between Oncology On the Go hosted by CancerNetwork® and the American Society for Transplantation and Cellular Therapy (ASTCT)'s program ASTCT Talks, Nora M. Gibson, MD, MSCE, and Taha Al-Juhaishi, MD, spoke about real-world applications of betibeglogene autotemcel (beti-cel; Zynteglo) as a treatment for patients with beta (β)-thalassemia. They spoke in the context of a study that Gibson presented at the 2025 Tandem Meetings, which evaluated patients who received commercial beti-cel in a single-center cohort following the agent's FDA approval in August 2022. Nora is a fourth-year fellow in bone marrow transplant and cellular therapy at the Children's Hospital of Philadelphia (CHOP), with a background in clinical research and epidemiology. Al-Juhaishi is the Associate Director of the Hematopoietic Stem Cell Transplantation and Cell Therapy Program at Oklahoma University Health Stephenson Cancer Center and an assistant professor of Medicine at the University of Oklahoma College of Medicine. Findings from Gibson's study revealed that among 10 patients who underwent stem cell collection at CHOP from 2022 to 2024, beti-cel yielded consistent red blood cell transfusion independence, with investigators noting prolonged platelet engraftment time and high platelet transfusion requirements. Beyond these findings, the conversation focused on how beti-cel compares with other currently available gene therapies for patients with hemoglobin disorders as well as non-curative therapies like allogeneic stem cell transplantation. Gibson and Al-Juhaishi also discussed strategies for mitigating occlusive disease and other potential toxicities associated with beti-cel. “It's a really exciting time to be working in this field where we finally have really good options for these patients. From our experience and from clinical trials, beti-cel and likely exagamglogene autotemcel [Casgevy]...are very effective, curative therapies for thalassemia in the real-world setting, and we've seen very similar results in sickle cell disease,” said Gibson. “These therapies have been really life-changing for our patients, and they've had a huge reduction in their symptoms and a huge reduction in their burden of health care that's required.” References 1. Gibson NM, Friedman DF, Elgarten CW, et al. Post-approval, real-world experience with betibeglogene autotemcel for transfusion-dependent beta thalassemia. Transplantation and Cellular Therapy. 2025;31(2):S254. doi:10.1016/j.jtct.2025.01.386. 2. FDA approves first cell-based gene therapy to treat adult and pediatric patients with beta-thalassemia who require regular blood transfusions. News Release. FDA. August 17, 2022. Accessed April 21, 2025. https://tinyurl.com/3vrkk8kz

On this episode host Justin Barnes recorded live at HIMSS25 in Las Vegas. Stay tuned for the next few weeks to hear all his guests.This week his guests are Adam Resnick, Director of the Center for Data Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia (CHOP), and Aneesh Chopra, Author, Innovator, Former U.S. CTO, CSO at Arcadia. To stream our Station live 24/7 visit www.HealthcareNOWRadio.com or ask your Smart Device to “….Play Healthcare NOW Radio”. Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen

A 2019 report showed that police violence is a leading cost of death for young Black men in the United States. About one in every 1,000 Black men can expect to be killed by the police, with the highest risk amongst all ethnic groups and genders between the ages of 20 and 35 years old. Police violence has been identified as a public health issue among public health experts as well as advocates and activists. What role, then, do doctors and pediatricians have in preparing patients and their families to be aware of this public health risk? On today's show, we're in conversation with two pediatricians who led the research of a recent peer-reviewed research letter, titled “Pediatrician Perspectives on Incorporating Discussion of Police Encounters Into Anticipatory Guidance for Black Youth and Their Caregivers“. Dr Jeffrey Eugene is a pediatrician and adolescent medicine specialist, working with the Children's Hospital of Philadelphia as well as Philadelphia FIGHT Community Health Centers. His clinical expertise is in adolescent and young adult primary care, gender affirming medical care, sexual and reproductive health, medical care for youth living with HIV, and eating disorders. Dr George Dalembert, is a pediatrician at the Children's Hospital of Philadelphia (CHOP) and an Assistant Professor of Clinical Pediatrics at the Perelman School of Medicine. Additionally, he serves on the Governance as well as Diversity, Equity, and Inclusion Committees of the Pennsylvania chapter of American Academy of Pediatrics. He is also an author on the report that we're discussing today. Read their research here: https://jamanetwork.com/journals/jamapediatrics/article-abstract/2829145 — Subscribe to this podcast: https://plinkhq.com/i/1637968343?to=page Get in touch: lawanddisorder@kpfa.org Follow us on socials @LawAndDis: https://twitter.com/LawAndDis; https://www.instagram.com/lawanddis/ The post The Public Health Risk of Police Violence and Pediatric Responsibility w/ Dr Jeffrey Eugene & Dr George Dalembert appeared first on KPFA.

January is Birth Defects Awareness Month. Dr. Scott Adzick MD is the Surgeon-In-Chief at Children's Hospital of Philadelphia (CHOP) and discusses with Mark the breakthroughs in fetal diagnosis now and what future treatment will look like. It's the 30th Anniversary of the fetal center at CHOP and it is remarkable how Dr. Adzick and his team's research and innovations have shaped the field of fetal medicine.

January is Birth Defects Awareness Month. Dr. Scott Adzick MD is the Surgeon-In-Chief at Children's Hospital of Philadelphia (CHOP) and discusses with Mark the breakthroughs in fetal diagnosis now and what future treatment will look like. It's the 30th Anniversary of the fetal center at CHOP and it is remarkable how Dr. Adzick and his team's research and innovations have shaped the field of fetal medicine.

In this interview, Anthony Guerra, Founder and Editor-in-Chief of healthsystemCIO, speaks with Shakeeb Akhter, Senior Vice President and Chief Digital & Information Officer at Children's Hospital of Philadelphia (CHOP), about the institution's ambitious digital transformation journey. Leading a multifaceted team, Akhter discusses how CHOP is advancing through strategic investments in AI, automation, digital patient experience, […] Source: CHOP Focused on Leveraging AI to ‘Transformational' Effect, Says Chief Digital & Information Officer Shakeeb Akhter on healthsystemcio.com - healthsystemCIO.com is the sole online-only publication dedicated to exclusively and comprehensively serving the information needs of healthcare CIOs.

Season 5: Episode 6 We know that physical activity is essential in our children's lives. Unfortunately, intense activity has greater risk of injuries. More than 2.6 million children and teens end up in the emergency room with sports injuries each year. In this episode, I spoke to Dr. Naomi Brown, Pediatric Sports Medicine Specialist, Children's Hospital of Philadelphia (CHOP) to find out how parents can prevent injuries and what to do when their child does get hurt. Resources are available at: chop.edu/sports Host: Isabel Prosper IG: @firsttimemomsbeyond35 Guest: Naomi Brown, MD, Pediatric Sports Medicine Specialist, Children's Hospital of Philadelphia (CHOP) --- Support this podcast: https://podcasters.spotify.com/pod/show/isabel-prosper/support

Teams at Children's Hospital of Philadelphia (CHOP) are committed to delivering breakthroughs for patients, including keeping them safe from injury – the leading cause of death and acquired disability for children. In this episode of Breaking Through, Madeline talks to CHOP expert Dr. Kristy Arbogast about how caregivers can keep kids safe during fall sports season and beyond – and about the work CHOP's Center for Injury Research and Prevention is leading to find new ways to prevent and treat concussions. They also discuss Dr. Arbogast's role on the NFL Engineering Committee, which is focused on developing injury prevention programs for elite athletes.

Sickle cell disease is an inherited blood disorder that often causes debilitating pain and life-threatening complications. Many patients with the disease make dozens of ER visits a year, and must receive regular blood transfusions. And though recent breakthroughs in gene therapy are giving patients with sickle cell new hope – and new options – accessing these therapies can be challenging. In this episode of Breaking Through, cell and gene therapy expert Dr. Stephan Grupp and pediatric hematologist Dr. Alexis Thompson join Madeline to talk about how gene therapy for sickle cell disease can transform patients' lives. They also discuss what teams at Children's Hospital of Philadelphia (CHOP) are doing to ensure that these innovative therapies reach the children who need them most. 

Stewart is joined by guest Dr. Ian Krantz, Founder of Philadelphia Concours d'Elegance and @CoolCarsforKids discussing The Concours, @SimeoneMuseum and Childrens Hospital of Philadelphia #CHOP. #Stuckeys @WaffleHouse @GooGooCluster

The team at Children's Hospital of Philadelphia (CHOP) believes that mental health is just as important as physical health – and they're working together to find solutions to the pediatric mental health crisis. In this episode of Breaking Through, Dr. Catharyn Turner, CHOP's Medical Director of Acute Inpatient Psychiatry, joins Madeline to discuss the innovative work CHOP is leading to improve access to pediatric mental health care, CHOP's new mental health facilities in West Philadelphia, and what's behind the rise in mental health conditions in children and teens.

Witnessing your child's bravery and resilience as they navigate a life-altering condition like hypoplastic left heart syndrome (HLHS) is both harrowing and inspiring. Hollie Stevenson joins Anna to share the profound story of her son Tom, who not only fought through the early challenges of HLHS but also the complex battle with protein-losing enteropathy (PLE) in his later years. Her vivid accounts from Tom's diagnosis in utero, through his surgeries, and onto his impressive transition into adulthood, working in politics, is nothing short of remarkable. Their journey underscores the unpredictable nature of congenital heart defects and the critical importance of vigilant medical care.Through Tom's story, we uncover the myriad of long-term treatments and daily hurdles that come with managing PLE. We discuss the innovative treatments at the Children's Hospital of Philadelphia (CHOP) that led to significant improvements in his health and share insights from another patient's experience where a medication for Crohn's disease offered unexpected relief. These narratives illuminate the evolving field of pediatric cardiology and the crucial balance of medication management, driving home the message that children with heart conditions can and should lead full, joyous lives.Parenting is an art—especially so when your child has a heart condition. Our conversation traverses the delicate art of letting go, allowing our children to taste independence and embrace life's experiences, from participating in sports to taking on careers. We explore the shift from advocacy to supporting our children's autonomy, the complexities of medication management into adulthood, and the emotional journey that comes with each milestone. Hollie and Anna share their personal challenges and triumphs, offering a heartfelt insight into what it means to parent through uncertainty with hope and courage. Join us for an episode that's not just about the struggles, but also the extraordinary victories that come with raising a child with a heart condition.Support the Show.Anna's Buzzsprout Affiliate LinkBaby Blue Sound CollectiveSocial Media Pages:Apple PodcastsFacebookInstagramMeWeTwitterYouTubeWebsite

What does it mean for HR leaders to bring their whole self to work when their identities are not the majority?Being an HR leader is already challenging, but being the only one who looks like you only amplifies those challenges.On this episode of HR Fresh Take, we're revisiting the conversation from our June 2023 event “The Black HR Experience”, hosted by Philly SHRM and the National Association of African Americans in Human Resources (NAAAHR),We'll dive into the Black experience and how that intersects with leadership roles within Human Resources and the organizations at large. We'll also discuss other areas such as allyship, psychological safety, and retaining Black talent.We're joined by Orien Barnes, VP of Organizational Development and Effectiveness at CHOP, Alain Doroseau, VP of Client Services at CCI Consulting, and Dr. Tanya O'Neill, Director of Organizational Development at Temple University Health System & Philly SHRM Board member. Leading the discussion is Co-host and Producer of HR Fresh Take, Kaela Blanks.More about Orien….Orien Barnes serves as Vice President of Organizational Effectiveness and Development, at The Children's Hospital of Philadelphia (CHOP). Orien is responsible for enterprise-wide vision, strategy, development, and communication of best-in-class practices to address organizational effectiveness, leadership development, learning and employee experience.Prior to joining CHOP, Orien spent 18 years at AmeriHealth Caritas in positions of increasing responsibility. Her last role at AmeriHealth was Vice President, HR Learning, Talent Management & Organizational Development, where she was responsible for developing the strategy and overseeing the design, implementation, and evaluation of programs that enhance organizational performance, facilitate professional development, and build strategically necessary capabilities and competencies. Orien holds a bachelor's degree in Computer and Information Science from Spelman College and a master's degree in Adult Training and Organizational Psychology from St. Joseph's University. She believes it is an honor to serve the employees, patients, and families of CHOP. One of her favorite quotes from Robert Greenleaf captures her leadership approach – “The servant-leader is servant first…it begins with the natural feeling that one wants to serve, to serve first.” While Orien has served in many roles in her career, her most important role is mom to her daughters, Madison and Jordyn. More about Alain….As Vice President, Client Services, Alain builds and maintains business relationships with leading HR executives in the Greater Philadelphia region. He has deep expertise in HR services and strategies and helps clients implement human capital management solutions that drive business performance. Prior to joining CCI Consulting, Alain worked for Insperity, a professional employer organization, where he provided human capital solutions and Fortune 500 HR tools to small and midsize business owners. A significant portion of his time was spent providing methods to C-suite executives so they could mitigate owner liability and risk. Additionally, Alain designed and launched successful proposals focused on retaining high potential talent and enhancing team effectiveness. He also created and delivered training and change management programs across functional areas. Known for his dynamic professional style and creative approach to working with clients, Alain thrives on helping businesses provide the healthiest and most bountiful workplace environment. He strives to unlock an organization's potential through analyzing data, identifying key performance indicators (KPIs), and, most importantly, Business, Engagement, Human Resources, Management, Thought Leadership, Return to work, Inclusion, Hybrid work, phillyshrm.org

Description: Co-host Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and co-host Holly Knotowicz, a speech-language pathologist living with EoE, who serves on APFED's Health Sciences Advisory Council, speak with Dr. Amanda Muir, an Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia. In this episode, Ryan and Holly interview Dr. Muir about tissue remodeling and eosinophilic esophagitis (EoE). Dr. Muir describes remodeling and stiffening, its effects, and how it relates to treatment and inflammation.   Listen in for information on remodeling and a pediatric study Dr. Muir is planning. Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:48] Co-host Ryan Piansky welcomes co-host Holly Knotowicz. Holly introduces Dr. Amanda Muir, an Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia (CHOP). She has a translational lab that investigates esophageal remodeling in the setting of EoE. Holly thanks Dr. Muir for joining us today.   [1:51] Dr. Muir became interested in eosinophilic disorders as a GI Fellow. There were so many patients with eosinophilic esophagitis and eosinophilic gastrointestinal diseases but there weren't many good therapies and little was known about the long-term results for children. [2:24] Dr. Muir's first eosinophilic interest was eosinophilic esophagitis. She joined a lab that was looking at how the esophagus changes over time in the setting of inflammation. After being in the lab, training, and learning all the skills and techniques, she was able to launch her career and lab.   [2:46] Dr. Muir started her own EoE clinic at CHOP (Children's Hospital of Philadelphia) as part of their Center for Pediatric Eosinophilic Disorders. She sees patients at the clinic, then she can bring questions from the clinic to the lab and talk about them as a group.   [3:28] Dr. Muir explains esophageal remodeling. There is remodeling that happens in the epithelial compartment of the esophagus. Then there's remodeling that happens underneath the surface in the lamina propria. For the most part, when people talk about remodeling in eosinophilic esophagitis, they refer to the remodeling happening below the surface.   [3:50] There is a burgeoning field dedicated to studying the surface of the esophagus, and Dr. Muir is also very interested in that. For today's purposes, we are talking about the remodeling that happens under the surface.   [4:03] Eosinophils that get to the esophagus secrete chemicals that excite the cells below the surface to secrete collagen. Collagen is the glue that holds the body together. They're secreting glue to help the esophagus hold together, and the esophagus gets stiffer and stiffer, over time. That is remodeling. It's the body trying to heal itself.   [5:04] Are children and adults equally at risk for remodeling? Patients develop a stiffening of the esophagus more, later in life. It is thought that the more years you have this inflammation, the more stiff your esophagus gets. There are patients six to nine years old who already have signs of stiffening.   [5:28] Dr. Calies Menard-Katcher from Colorado published a paper where she described all of the eosinophilic esophagitis patients at her institution who got dilated. Dilation is the process of a balloon stretching your esophagus open when it's too narrow. She had patients as young as six in her cohort that she described as having EoE strictures.   [5:49] Remodeling happens with younger patients but we're not as good at finding it.   [6:08] Any type of inflammation in the GI tract can lead to some stiffening. The typical gastrointestinal disease that we think of as remodeling is Crohn's Disease. An inflammatory process happens in the small bowel or colon that leads to narrowing and stiffness in the intestines. [6:28] Also GERD (reflux) can lead to stricture, over time. It is just much more rare to see a GERD-induced stricture as opposed to EoE.   [7:13] We are not sure, but to some extent, we think of remodeling as not being reversible. Once there is a certain degree of stiffness, the esophagus does not seem to open up without these dilations. If you can control the inflammation, you can halt the stiffening. Maybe there is some degree of reversibility.   [7:44] In the Phase 2 dupilumab trials, investigators found that patients on dupilumab were seen to gain two millimeters in diameter of the esophagus, compared to the patients on placebo. We may be able to prevent some remodeling if we catch it soon enough. More research is needed.   [8:33] Dr. Muir tells of the work she is doing in her lab. They take biopsies from patients and grow collagen-secreting fibroblasts in a dish. The research is to find out what calms the fibroblasts down from actively secreting collagen.   [9:22] It's tough to follow the symptoms of EoE when patients only have difficulty swallowing foods that are hard to swallow. If patients are not challenging their esophagus, they might not notice having daily trouble swallowing. It's hard to ask a young kid who is eating a lot of soft foods if they feel like anything's getting stuck.   [10:06] Dr. Muir will ask teenage patients, “Do you ever want to eat chicken? Do you ever want to eat steak?” A lot of times they don't want to eat it, perhaps because it felt uncomfortable at some point in their life and they don't want to eat it, not based on taste but on repeated bad events. It's hard to tease out the symptoms, sometimes.   [10:27] Dr. Muir says, based on our Functional Luminal Imaging Probe (FLIP) studies, patients who had feelings of food that felt stuck in the last 30 days did seem to have a more narrow caliber esophagus. There is not a 100% correlation between symptoms and remodeling, but there seems to be some correlation.   [11:31] Ryan tells how patients have tendencies to get around their EoE symptoms, with a personal example of keeping food in his mouth and chewing it for a long time before swallowing. A scope would show he had bad inflammation of the esophagus. He had been diagnosed when young and was under treatment and on a restricted diet.   [12:26] Biopsies don't always get a sample below the surface to check for fibrotic cells so it is hard to find remodeling with biopsies. There are some visual signs. Seeing rings or trachealization in the esophagus, or narrowing, can be signs that there is some remodeling under the surface.   [13:38] For kids who have a lot of trouble swallowing, Dr. Muir performs an EndoFLIP test regularly. The test catches subtle narrowing that may not be visible to the endoscopist. Doing this test gives the doctor more information and a better sense of the patient's phenotype, such as inflammation, the esophagus being stretchy, or being stiff.   [14:49] The EndoFLIP is a balloon with an imaging probe that includes a TV for the doctor to see how many millimeters the esophagus is in diameter as the balloon inflates along the whole body of the esophagus. It's not an imaging test that goes to radiology. It's a balloon that is blown up slowly with salt water and that gives this measurement.   [15:18] The EndoFLIP is a helpful tool to help determine who may have some more stiffening or determine exactly what the diameter of the esophagus is before starting treatment.   [15:33] One of the things that Dr. Menard-Katcher of Colorado, Dr. Ackerman of the University of Illinois, and Dr. Muir collaborated on was to look and see if they could find any markers in the esophagus that would relate to some of the things that are obtainable on biopsy or the esophageal string test.   [15:57] What they found was that periostin — a protein made by the epithelium and by the fibroblasts, which is known to activate fibroblasts, and is very high in EoE — seemed to correlate with the EndoFLIP measurements. This makes Dr. Muir think that there might be some potential for biomarkers to detect remodeling.   [16:16] The thing that everyone wants for this disease is to find a biomarker where we don't have to do a scope. As far as finding a non-invasive biomarker, we're not there, yet. There are some things going on at the tissue level that might clue us in on how distensible the esophagus is.   [17:18] The thing Dr. Muir worries about the most with long-term inflammation is that the esophagus is going to get more narrow over time. That will make patients more susceptible to food impaction (although not all patients with food impaction have a stricture).   [17:36] One worry is that the esophagus will get so narrow that an endoscope will not be able to pass a stricture. That will lead to more swallowing problems. That is what Dr. Muir hopes to be able to prevent as we get better at treating this.   [18:09] Any of the treatments that stop the inflammation and help get you below that “magical” 15 eosinophil count that we all strive for, will help prevent remodeling. So, once you get everything calm, hopefully, the remodeling process will stop. However, with the stiffening, the fibroblasts get more excited and have a hard time turning off.   [18:53] Simply turning off the inflammation will not turn off the fibroblasts. Many people within the GI space are looking at fibroblast-directed therapy, especially in Crohn's disease, there's a real need to prevent a lot of surgeries that are happening. Dr. Muir hopes to apply some of these to the esophagus, as well.   [19:16] In the study by Dr. Menard-Katcher, Dr. Ackerman, and Dr. Muir, there were 80 patients. Some were on swallowed steroid treatment and others were on an elimination diet. There were not enough patients on each therapy to find a significant difference in remodeling between the therapies. Patients in remission had better distensibility.   [19:44] Dr. Evan Dellon showed in a paper that patients who have sustained remission have fewer dilations, in the long term. While we don't have a way to reverse the fibrosis that's happened, we hope to prevent it from getting any worse. Dr. Muir's research goal is to find something to calm fibroblasts down and prevent fibrosis or even reverse it.   [20:31] Dr. Muir explains that cells under the surface level are fibroblasts. When eosinophils and T cells come in and secrete antagonizing chemicals, the fibroblasts turn on and start secreting collagen. The fibroblasts also turn on when the epithelium is angry and inflamed. There is also evidence that surface cells can secrete collagen.   [22:46] Dr. Muir says it's hard to know how far along in development some anti-fibrotic drugs are. We have many promising targets. Understanding how the remodeling happens is very important to be able eventually to treat this disease. Even though it seems like incremental progress, Dr. Muir believes research is moving the field forward.   [24:16] Dr. Muir says her EoE patients at CHOP are generous with their blood and tissue. Getting consenting control patients for lab studies involves a lot of leaps of faith and trust that scientists will grow your cells ethically. Dr. Muir feels lucky she has a good research team that explains things in lay terms to control patients.   [26:50] Dr. Muir's team has videotaped pediatric EoE patients and control patients' eating. The time EoE patients spent chewing and how long it took to swallow correlated to their esophageal distensibility measured by the EndoFLIP test. She believes that how we feed and the difficulty we have swallowing have to do with esophageal remodeling.   [27:41] That's Dr. Muir's next area of study. It's being spearheaded by Dr. Kanak Kennedy, a fellow in Dr. Muir's lab, trying to figure out the relationship between pediatric feeding and remodeling.   [28:08] As part of their research, they are videotaping as many kids eating as they can. This involves many control patients who don't have EoE. Another area of research is on the enzyme lysyl oxidase which organizes collagen into bundles and makes it stiff. She is looking into ways to decrease the organization of the collagen.   [29:08] Ryan thanks Dr. Amanda Muir for coming on the podcast and giving a crash course on remodeling and EoE.   [29:14] To learn more about eosinophilic esophagitis, visit apfed.org/eoe. To learn more about Dr. Muir's research, read her paper.   [29:30] To find a specialist, visit apfed.org/specialists. To connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [29:47] Ryan and Holly thank Dr. Amanda Muir again for joining them. Holly thanks APFED's education partners, linked below, for supporting this episode.   Mentioned in This Episode: Amanda Muir, MD. Children's Hospital of Philadelphia (CHOP) American Partnership for Eosinophilic Disorders (APFED) APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of AstraZeneca, Bristol Myers Squibb, Sanofi, and Regeneron.   Tweetables:   “I was able to start my own EoE clinic at CHOP as part of their Center for Pediatric Eosinophilic Disorders. I see patients who have eosinophilic gastrointestinal diseases and then I can go back to the lab and bring those questions from my clinic to the lab.” — Dr. Amanda Muir   “The thing that everyone wants for this disease is to find a biomarker where we don't have to do a scope.” — Dr. Amanda Muir   “Any of the treatments that stop the inflammation and help get you below that ‘magical' 15 eosinophil count that we all strive for will help prevent remodeling. So, once you get everything calm, hopefully, the remodeling process will stop.” — Dr. Amanda Muir   About Dr. Amanda Muir: Amanda B. Muir, MD, Attending Physician, Children's Hospital of Philadelphia, Research Institute. Dr. Muir investigates the mechanisms underlying esophageal fibrosis to improve therapeutic and diagnostic approaches.

**Disclaimer: The information in this podcast should not be construed as medical advice. Please consult with your health care provider regarding your medical decisions and treatment. Any listed resources are not intended to be endorsements.**In this podcast, Peggy converses with Leila Zengel, who shares her family's journey and challenges following her 10 year-old daughter Julie's bone marrow transplant. Julie, diagnosed with (refractory) Ph-like ALL in January 2018, underwent a  transplant in June 2018 at the Children's Hospital of Philadelphia (CHOP) with her brother Jacob as her donor. Leila, a former school counselor and educator, delves into the complexities of transitioning to a full-time caregiver role for her daughter.The conversation begins with Julie's diagnosis and the subsequent need for a transplant, highlighting the difficulties in finding effective treatment. Leila describes her shift from a professional career to focusing entirely on Julie's care, emphasizing the drastic change in their family life. The process was challenging, as Julie did not respond well to initial treatments, leading to the critical decision for a transplant.Leila shares the emotional and logistical challenges faced during the post-transplant phase, particularly the adjustments required when returning home. Living two hours away from the hospital posed additional difficulties. She speaks about the nuances of balancing care for Julie while managing the rest of the family, including her son Jacob. Leila's story is a deep dive into the realities of caregiving, from handling the medical complexities to the emotional toll on the family.Leila talks about the importance of self-care for caregivers. Leila stresses the need for moments of rest and relaxation amidst the demanding role of caring for a child with a serious medical condition. She talks about the value of simple activities like puzzles and reading, which provided her with much-needed respite.Leila also discusses the unexpected medical challenges that emerged post-transplant, such as chronic graft-versus-host disease. Despite these hurdles, Julie's gradual recovery is a testament to the resilience of both the child and the family. Leila highlights Julie's return to normal activities, including participating in the school band, as milestones in her recovery.Family dynamics and adapting to a new normal at home are central themes. Leila explains how they navigated through changes, setting boundaries to protect Julie's health and creating new family traditions. She emphasizes the importance of living in the present and finding joy in small moments, reflecting on the perspective gained through this challenging journey.Lastly, the role of support systems, particularly the medical team and communities like Momcology, is discussed. Leila underscores the value of these networks in providing support and understanding to families undergoing similar experiences. The podcast ends with Leila offering insights and advice for other caregivers, highlighting the importance of community, self-care, and focusing on the present.Momcology Website: https://momcology.org/Other ResourcesNational Bone Marrow Transplant Link - (800) LINK-BMT, or (800) 546-5268.nbmtLINK Website: https://www.nbmtlink.org/nbmtLINK Facebook Page:  https://www.facebook.com/nbmtLINKnbmtLINK YouTube Page can be found by clicking here.Thank you to our sponsors. This season is supported by a healthcare contribution from Sanofi  https://www.sanofi.com/

Debra L. Friedman, M.D., is a professor of Pediatrics in the Division of Hematology and Oncology at the Monroe Carell Jr. Children's Hospital at Vanderbilt. She is the E. Bronson Ingram Chair of Pediatric Oncology and the leader of the Cancer Control and Prevention Program and directs the Cancer Survivorship programs at the Vanderbilt-Ingram Cancer Center. Dr. Friedman's research interests lie in the long term outcomes for cancer survivors, as well as in the design of novel therapeutic protocols for childhood cancer, designed to decrease adverse long-term effects of therapy. She has leadership roles in Children's Oncology Group (COG) and is an internationally recognized expert in cancer survivorship, participating in projects evaluating best practices and models of care. She is investigating a diverse group of physiologic and psychosocial outcomes among survivors of pediatric cancer, hematopoietic stem cell transplant and medical oncology. Friedman completed her pediatric residency and a joint fellowship in Pediatric Hematology/Oncology and Cancer Epidemiology at the University of Pennsylvania and The Children's Hospital of Philadelphia (CHOP). Prior to coming to Vanderbilt in 2008, she served as the co-director of the Cancer Survivorship Program at CHOP and then, as the founder and director of the Fred Hutchinson Cancer Research Center Survivorship Program. ---- What We Do at MIB Agents: PROGRAMS: End-of-Life MISSIONS Gamer Agents Agent Writers Prayer Agents Healing Hearts - Bereaved Parent and Sibling Support Ambassador Agents - Peer Support Warrior Mail Young Adult Survivorship Support Group EDUCATION for physicians, researchers and families: OsteoBites, weekly webinar & podcast with thought leaders and innovators in Osteosarcoma MIB Book: Osteosarcoma: From our Families to Yours RESEARCH: Annual MIB FACTOR Research Conference Funding multiple $100,000 and $50,000 grants annually for OS research MIB Testing & Research Directory The Osteosarcoma Project partner with Broad Institute of MIT and Harvard ... Kids are still dying with 40+ year old treatments. Help us MakeItBetter. https://www.mibagents.org​ Help support MIB Agents, Donate here https://give-usa.keela.co/embed/YAipuSaWxHPJP7RCJ SUBSCRIBE for all the Osteosarcoma Intel

Join us as we engage in a wide-ranging discussion with Madeline Bell, the President and CEO of the renowned Children's Hospital of Philadelphia (CHOP). Madeline shares insights into CHOP's pivotal role in addressing critical issues such as gun violence, health equity, and behavioral health for children in the diverse landscape of Philadelphia. She highlights CHOP's pioneering work in gene and cell therapy, illustrating the cutting-edge potential of these treatments. Don't miss this informative episode as we explore the multifaceted world of pediatric healthcare with one of its foremost leaders.

Join us as we engage in a wide-ranging discussion with Madeline Bell, the President and CEO of the renowned Children's Hospital of Philadelphia (CHOP). Madeline shares insights into CHOP's pivotal role in addressing critical issues such as gun violence, health equity, and behavioral health for children in the diverse landscape of Philadelphia. She highlights CHOP's pioneering work in gene and cell therapy, illustrating the cutting-edge potential of these treatments. Don't miss this informative episode as we explore the multifaceted world of pediatric healthcare with one of its foremost leaders.

In this episode of the Faculty Factory Podcast, we chat with Meryl S. Cohen, MD, MS Ed, about the art of staying resilient and resourceful for long-term success in academic medicine and beyond. Dr. Cohen is a Professor of Pediatrics and Associate Dean for Faculty Development at the University of Pennsylvania's Perelman School of Medicine. She also serves as Associate Chief in the Division of Cardiology at The Children's Hospital of Philadelphia (CHOP). Dr. Cohen's remarkable career as a pediatric cardiologist, coupled with her leadership roles and unique pathway towards success in academic medicine, sheds light on the importance of being resourceful and never giving up. As you will discover in this discussion, though the journey may be challenging, it's the triumph over these challenges that makes the eventual success immensely rewarding. Learn how Dr. Cohen overcame challenges, managed time effectively, and made impactful contributions to her field, all while navigating the demands of motherhood and building a national presence in the world of pediatric cardiology. Learn More: https://facultyfactory.org/ 

Sydney & Brett Stelmaszek are heavily involved in the SRF community. Sydney is on the BOD, is a patient advocate, and coordinates our connection with Children's Hospital of Philadelphia (CHOP). Brett is the driving force behind Cannonball for the Cure (CFTC), an annual fundraiser where SYNGAP1 parents drive cross country live-streaming the entire journey to raise awareness of SYNGAP1. This episode touches on their involvement with SRF as well as raising their son Emmitt, diagnosed with SYNGAP1 while living in South Africa. Their story of excessive seizures, aggression, hope, and love while caring for Emmitt and his two brothers is at times heart-breaking, but always heartwarming. Emmitt's Warrior Story Eating with Emmitt - Blog Post Flying & Seizing from Africa to Florida - Emmitt's Story Sydney's SRF Bio Follow Sydney & Brett: Instagram - @UFD_Tech Twitter - @SydneyStel & @UFDTech Facebook - Sydney YouTube - @UFDTech YouTube - Our Syngap Journey More links: Cannonball for the Cure Natural History Study at CHOP SPECIAL WEBINAR: $25M Gift to ENDD for SYNGAP1 and STXBP1 MDBR - Blog Post by Sydney Follow ⁠⁠⁠⁠⁠⁠Ashley Frye⁠⁠⁠⁠⁠⁠: ⁠⁠⁠SRF Bio⁠⁠⁠ ⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠Facebook⁠⁠⁠⁠⁠ ⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Nathan's Warrior Story⁠⁠⁠⁠⁠ SYNGAP1 Stories ⁠⁠⁠⁠⁠⁠Episode 001⁠⁠⁠⁠⁠⁠ - Ashley Frye SRF & SYNGAP1 Info:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠What is SYNGAP1?⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Syngap Research Fund⁠⁠ - ⁠⁠⁠https://syngapresearchfund.org⁠⁠⁠ Donate - ⁠⁠⁠⁠⁠⁠⁠⁠https://Syngap.Fund/Donate⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠SYNGAP1 & Epilepsy⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠Why Getting a Genetic Diagnosis Matters⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠How to Get Free Genetic Testing⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Special Needs Trusts⁠⁠⁠⁠⁠⁠⁠⁠ Connect with SRF (@curesyngap1): ⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠SYNGAP10 Weekly Video Podcast⁠⁠⁠⁠⁠⁠⁠⁠ w/ Mike SYNGAP1 Conference 2023, hosted by SRF - ⁠⁠⁠⁠Registration⁠⁠⁠⁠ Wednesday SRF Family Zoom Meeting: ⁠⁠⁠⁠Syngap.Fund/SRFfam⁠⁠⁠⁠⁠⁠⁠⁠ Meeting ID - 972 0059 2178 Passcode - 848417 Comments: ed@curesyngap1.org Music: ⁠⁠⁠⁠⁠⁠⁠⁠In the Forest... by Lesfm from Pixabay ⁠⁠⁠⁠⁠⁠⁠ Episode 018 SYNGAP1 Stories, September 19, 2023 #SYNGAP1StoriesEmmitt #Syngap #SYNGAP1 #SYNGAP1Stories #SYNGAP1StoriesEp18 #Epilepsy #EpilepsyAwareness #Autism #AutismAwareness #IntellectualDisability #ID #Anxiety #RareDisease #RareDiseaseResearch #SynGAPResearchFund #CareAboutRare #Advocacy #PatientAdvocacy #Neurology #GeneticTesting #Therapy #Family #Water #Agression #Behavior #Cannonball #CFTC #UFD

Dr. Paul Offit is a pediatrician specializing in infectious diseases and an expert on vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine, credited with saving hundreds of lives daily. Offit is the Maurice R. Hilleman professor of vaccinology, professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania, and director of The Vaccine Education Center at  Children's Hospital of Philadelphia (CHOP). Offit is currently a member of the National Institutes of Health (NIH) working group on vaccines.Support the show

In this episode, your host Amy Milne gets real with Kevin McMahon, Sr. Director, Peer to Peer & Community Fundraising at Children's Hospital of Philadelphia (CHOP for short!). When Kevin left his marketing job with the Philadelphia Eagles to join CHOP 11 years ago, he had no experience in healthcare and would get tripped up (and even struggle to pronounce!) the word 'philanthropy'. Those days are long over. Kevin walks us through their events portfolio which is divided into four categories: special events, executive events, peer-to-peer events and community events. He emphasizes the importance of being donor-centric and how having great relationships with other teams (marketing, communications, individual giving, etc.) is the key to success. Kevin lets us in on his own definition of "R and D" (it's not what you think!) and reminds us that you don't always have to create an original event idea. The Philly Spin-In event is a great example of an event concept that existed in the peer-to-peer space, and by ensuring that it made sense for them as an organization and met their strategic objectives, it became a very successful fundraising event. Kevin and Amy also have an important conversation around how to recognize those who are participating in memory of a lost loved one. Kevin's words of wisdom are worth their weight in gold, so we highly recommend having a pen and paper ready so you don't miss anything!For more information on the amazing work that CHOP is doing, check out their website.“If we lead with community and belonging, then fundraising will follow.” – Kevin McMahonConnect with us:Beyond Fundraising Inc: https://www.startingbeyond.com/LinkedIn: https://www.linkedin.com/in/amy-milne-8946791/Instagram: https://www.instagram.com/milneamyr/https://www.instagram.com/startbeyond/

Here we look back upon The Anesthesia Patient Safety Foundation (APSF) at last year's Anesthesiology conference. This piece is presented by Desiree Chappell and Monty Mythen with their guests JW Beard, Chief Medical Officer of GE Patient Care solutions, GE Healthcare, APSF Board of Directors and Jeffery Feldman, Attending Anesthesiologist, Children's Hospital of Philadelphia (CHOP) and Professor of Clinical Anesthesiology at the Perelman School of Medicine, University of Pennsylvania, APSF Board of Directors. The educational resources mentioned in this piece are here: https://www.apsf.org/apsf-technology-education-initiative/ The APSF website is here: http://www.apsf.org We spoke previously to The Anesthesia Patient Safety Foundation in 2019 here: https://www.topmedtalk.com/asa-2019-anesthesia-patient-safety-foundation-mark-warner/ We also consulted them during our coverage of the COVID-19 crisis: https://www.topmedtalk.com/the-anesthesia-patient-safety-foundation-covid-19/ TopMedTalk; proud to be partnered with the American Society of Anesthesiologists® at ANESTHESIOLOGY® 2022. -- TopMedTalk is provided to you for free; if you want to help support our work and help give these conversations a wider audience please like and subscribe (if and where possible) before sharing it on your social media. TopMedTalk can be found on YouTube here: https://www.youtube.com/channel/UC-HYQmeIwcFCYO1hoQ8jShQ We are on Twitter here: https://twitter.com/topmedtalk We are on LinkedIn here: https://www.linkedin.com/company/topmedtalk We are on Facebook here: https://www.facebook.com/TopMedTalk1/

Meet Our Guest: Madeline Bell is the President and CEO of Children's Hospital of Philadelphia (CHOP), which is one of the top-ranked children's hospitals in the United States and was ranked No. 1 on Forbes' 2022 list of America's Best Large Employers. Most recently, she was named one of Modern Healthcare's “100 Most Influential People in Healthcare” and one of its “50 Most Influential Clinical Executives” and was included on Forbes' “50 Over 50: Vision” list, Philadelphia Business Journal's “Power 100 2022” list, and Philadelphia Magazine's list of “The 100 Most Influential People in Philadelphia.” Ms. Bell is the host of Breaking Through with Madeline Bell, a podcast that features interviews with CHOP patients, doctors and scientists, as well as with philanthropists and innovators who support CHOP's mission. She holds a bachelor of science in Nursing from Villanova University and a master of science in Organizational Dynamics from the University of Pennsylvania. Key Insights: Madeline Bell, President and CEO of the Children's Hospital of Philadelphia (CHOP), shares her career journey from a pediatric nurse to hospital administration. ● The Curiosity Trajectory. Madeline emphasizes the importance of curiosity and a desire for more decision-making power in her career trajectory.● Networking for Women. Networking has been a challenge for women, including Madeline, but she encourages women to be intentional and planful in developing their networks.● Follow the Leader. As a leader, Madeline believes in inspiring and uniting people around a common purpose, helping them understand their role and the bigger picture. This episode is hosted by Sandi Fenwick, Former CEO, Boston Children's Hospital. Relevant Links: Read more about MadelineChildren's Hospital of Philadelphia

Description: Co-host Mary Jo Strobel, APFED's Executive Director, is joined by co-host Holly Knotowicz, a speech-language pathologist and feeding specialist living with eosinophilic esophagitis (EoE) who serves on APFED's Health Sciences Advisory Council. They talk with guest Dr. James Franciosi, Chief of the Division of Gastroenterology, Hepatology, and Nutrition at Nemours Children's Health in Orlando, Florida. In this episode, Mary Jo Strobel and Holly Knotowicz interview Dr. James Franciosi about his research with proton pump inhibitors, personalized medicine, the different factors that influence the response EoE patients may have to very high dose PPI treatments and other treatments, including dietary eliminations, swallowed oral steroid medications, and for some patients, biologic medications. Dr. Franciosi explains the uses of these various treatments and compares the risks of medical treatments with the risk of untreated EoE. He also describes the potential for advances in treatment choices.   Disclaimer: The information provided in this podcast is designed to support, not replace the relationship that exists between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:49] Co-host Mary Jo Strobel welcomes co-host Holly Knotowicz. Holly introduces the topic of proton pump inhibitors and EoE.   [1:28] Holly introduces Dr. James Franciosi, Chief of the Division of Gastroenterology, Hepatology, and Nutrition at Nemours Children's Health in Orlando, Florida.   [1:39] Since 2008, Dr. Franciosi has cared for children and teens with eosinophilic esophagitis (EoE) and eosinophilic gastrointestinal diseases (EGIDs). His team's mission is to reduce the symptoms of EoE and EGIDs and they have published more than 60 peer-reviewed publications.   [1:55] Holly thanks Dr. Franciosi for joining the podcast.   [2:06] Dr. Franciosi “grew up” with Beth Mays (now Beth Allen), whose family suffered from eosinophilic GI disease. When Dr. Franciosi was at the Children's Hospital of Philadelphia (CHOP), he became very interested in eosinophilic esophagitis, which was starting to emerge as something that was different from gastroesophageal reflux.   [2:30] Dr. Franciosi had the opportunity to work with Dr. Liacouras, Dr. Spergel, and many others at CHOP. He transitioned to Cincinnati Children's Hospital with the leadership of Dr. Marc Rothenberg, Dr. Phil Putnam, and a group trying to optimize the care for children with eosinophilic GI disease.   [3:01] Dr. Franciosi then moved to a leadership role at Nemours Children's Health in Orlando, Florida. He has been with Nemours Children's Health for the past 11 years. There he has done additional research in eosinophilic disease and seen many changes for the good with these conditions.   [3:37] Mary Jo notes that early in his career, Dr. Franciosi had worked with Beth Mays, now Beth Allen, who is one of the founders of APFED. Dr. Franciosi has been working with eosinophilic diseases since the time APFED was founded.   [3:56] Dr. Franciosi has conducted research into how the role of proton pump inhibitors (PPIs) in the evaluation and treatment of EoE has evolved over time. His team is very interested in what therapies may be effective for eosinophilic esophagitis (EoE) for individual patients.   [4:24] The research Dr. Franciosi has been doing for EoE and other conditions is trying to look at the right drug for the right patient, with the right dosing, etc. He calls that precision medicine or personalized medicine.   [4:39] Proton pump inhibitors (PPIs) are medications that have been around for decades. There has been an evolution of thought about whether this is a medicine that we use to define the condition of EoE or now something we can use as a treatment option.   [4:57] There have not been any randomized, placebo-controlled clinical trials for EoE using this medication and there has been a lot of variability in the literature about how well they work. That's some of the research Dr. Franciosi has been looking into and also making sure that these are communicated as an option for the right patients with EoE.   [5:27] PPIs are traditionally thought of as blocking one of the common pathways for acid in the stomach. A proton pump in parietal cells in the GI tract pumps acid into the stomach that helps you fight bad bacteria. Sometimes the acid can cause irritation in the GI tract,  the stomach, and the esophagus. The PPIs work to block those pumps.   [6:15] Over the past several decades, the thinking around EoE has evolved from it being thought to be a reflux condition that had a lot of eosinophils or allergic cells, that just didn't get better, to being thought of as strictly different from reflux, to thinking that it may be a mix for some patients.   [6:42] As the first guidelines for EoE were developed, the initial thought was to use the PPI medications to exclude gastroesophageal reflux. In the first consensus guidelines, patients had to fail the proton pump inhibitors at a high dose to be defined as EoE. This has changed over time. In 2018 there were new guidelines with new research.   [7:15] The newer thinking is that the PPIs are not to make the diagnosis, but they're one of several different therapies that we can use; dietary interventions and different medications, including PPIs, swallowed steroids, and some of the newer biologic medications.   [8:14] H2 blockers are some of the older medications that block acid in the stomach, but they block it in a different way. They block the histamine type-2 receptor, one of the pathways by which acid is produced in the stomach. The proton pump inhibitors block the proton pump. They're stronger medications and they work better for acid.   [8:46] The H2RA medications have names that end in “tidine” like famotidine. The PPI medications have names that end with “azole” like pantoprazole or esomeprazole.   [9:45] EoE is a condition that we've learned a lot about over the past several decades. The PPI medications may have different functions. They may block the acid in the stomach; they may also have a role in reducing some of the inflammation. This led to questioning if PPIs should be used to make a diagnosis or as a choice of therapy.   [10:36] From the 1990s to the 2000 era, to the most recent guidelines in 2018, the thinking about the treatment of EoE and the use of PPIs has evolved.   [10:49] One of the important things to know is that just because you've been on a PPI, doesn't mean that you're on a high dose of PPI therapy. This is important in children and different practices.   [11:12] The general recommendation for PPI therapies is to use a high dose of PPI twice a day. For adults, that's 40 mg of esomeprazole twice a day. For children, it's 1 mg per kg of body weight twice a day. That's a high dose. For some people, it may be that the medication was not used at a high dose.   [11:37] The goal ultimately is to back off the high dose and to decrease the amount of medication that's being administered.   [11:47] Dr. Franciosi says the main surprise in his findings was that the studies in both adults and children are “all over the place.” Some people report a 30% or 20% response; other colleagues throughout the world have reported a response of about two-thirds of the patients. It was surprising to see how variable the response was.   [12:18] Dr. Franciosi thinks there is variation in the choice of PPI medications, the dosing, and how they're administered. Dr. Franciosi and his team are also looking at how people respond to these medications. That's where personalized medicine comes in; your genes, and factors in your body can influence how well you are responding.   [12:53] Precision medicine has been used in pediatric gastroenterology for inflammatory bowel disease with medications like 6-mercaptopurine, azathioprine, and some of the biologic medications. People can respond differently to medication. Genetic variation or other factors may create different patterns of response to the same medications.   [13:25] Precision medicine and personalized medicine are interchangeable terms.   [13:48] Before reviewing the literature for his most recent publication, Dr. Franciosi had done some genetic testing and identified that there are genetic variations that do influence how people respond or don't respond to the PPI medications.   [14:09] We need to learn more about genetic variations. Dr. Franciosi thinks for every new diagnosis of EoE, PPIs should be considered as a medication. It's important for patients and families to know the different options. Providers may have their own biases but they should lay out the options for their patients and families to decide.    [14:47] Dietary intervention has significant benefits for children, teens, and adults. There can be hardships with quality of life that have to be considered. Taking medication for the long term also has considerations. The newer biologic medications are a fantastic step forward but they are expensive. They are just starting to be used for EoE.   [15:21] Dr. Franciosi likes to identify to his patients that there are options in treatments: dietary elimination, proton pump inhibitors, swallowed steroids, and biologic medication for people who have strictures (narrowing) in their esophagus or fibro stenosis (scar tissue). These patients are less likely to respond to PPI medication.   [15:57] We need to do more research on this and more future prospective trials, patients with scarring are those where a different type of therapy beyond the PPI medications. Patients with inflammatory symptoms seem to respond to PPI medication.   [17:04] Dr. Franciosi's patients and families are making some choices together. Dietary elimination may not be the right choice for certain patients but they need to have the option. Dr. Franciosi presents dietary elimination as effective for many patients. It's an investment upfront. It presents the benefit of not using long-term medications.   [17:44] Sometimes when children have growth concerns, or the dietary interventions don't work or are not possible, different medications may be considered.   [18:13] The benefit of using PPIs in treatment is that you can reduce the inflammation that's occurring, alleviate symptoms and make patients feel better. There has been some debate about whether this is related to the acid primarily in the stomach and some breaks in the esophagus lining that cause antigens to go in and cause inflammation.   [18:51] Dr. Franciosi uses a balanced approach with patients and families. He tells them every treatment has risks associated with it. Also, not treating EoE has risks. He did studies at Cincinnati on what happened to patients 15 years later if they were untreated. It can involve more scar tissue, strictures, symptoms, and growth issues.   [19:37] PPIs have gotten a lot of bad press over the past few years, primarily looking at the rates of infection. When you block stomach acid, that acid is no longer there to kill bad bacteria. So there are more associated respiratory infections and stomach infections like gastroenteritis, GI bugs, etc.   [20:02] Other risks that have been talked about are dementia and kidney issues, often in older populations and patients who are generally sicker. Many people are on PPIs for general GI disorders unnecessarily. If you don't need a drug, you shouldn't be on it.   [20:34] The risk/benefit analysis of the infections, and other people have talked about low bone mineral density, etc., have to be balanced with the risk of untreated disease and the potential risk of other medications, as well.   [21:14] For the vast majority of patients, EoE is a chronic, long-term condition. Once you take the treatment away, whether that's eliminating foods, or taking medication, the condition will come right back. That's also true with proton pump inhibitors.   [21:36] The recommended approach for PPIs is a high dose of medication twice a day, to start, a repeat endoscopy after eight to 12 weeks, and come down to maintenance, which would just be once a day.   [21:55] Colleagues in Spain, who have published on this, have said about two-thirds of patients responded to the really high dose PPI medications and that among those people that respond, about two-thirds continue on maintenance and do well. Not everybody will necessarily respond or do OK with the lower dose of medication.   [22:17] In general, if you take away the medications or the treatment that you're using, the disease will come right back and those risks of progression or scar tissue, creating strictures, and developing symptoms would return as well.    [22:39] If you are considering PPIs, ask your doctor their perspective on the different treatments that Dr. Franciosi has been discussing here. Considerations include PPIs, dietary elimination, swallowed steroid medications, and for some patients, biologic medications. Dr. Franciosi thinks biologics will become more used over the years.   [23:43] Dr. Franciosi would recommend asking a treating provider about the choice of PPI medications, the dosing that they're planning to use, whether or not it is high-dose medication, and even what the plan is for coming down off the medication with an endoscopy or a transnasal endoscopy in eight to 12 weeks, and maintenance.   [24:03] In the U.S., high-dose PPI may not be covered by insurance. They may approve 40 mg of esomeprazole once a day but not twice a day, or make it challenging to get approved. The patients may do the second dose over the counter and Dr. Franciosi will walk them through how to do that.   [24:58] Dr. Franciosi thinks the ideal would be that patients are diagnosed with eosinophilic esophagitis and then get a cheek swab to determine their profile and what kind of response they will have using esomeprazole or if he recommends oral viscous budesonide or fluticasone. It would also be great to identify who may respond or not respond to biologic medications.   [25:37] The ideal of personalized or precision medicine is to be able to identify the right choice of treatment, including dietary approaches, for the right patient, at the right dosing.   [25:50] An underappreciated area for EoE is recognizing that we don't have good testing to identify food reactions, allergies, etc. It would be wonderful. Allergy testing doesn't correlate because it's mostly IgE based. So that's a reason for dietary elimination.   [26:38] Mary Jo and Holly thank Dr. Franciosi for participating in the podcast. Dr. Franciosi says the takeaway is that PPIs should be considered as an option for various patients.   [27:20] To learn more about eosinophilic esophagitis, visit apfed.org/eoe, apfed.org/specialists, and apfed.org/eos-connections. Holly and Mary Jo thank APFED's education partners, linked below.   Mentioned in This Episode: American Partnership for Eosinophilic Disorders (APFED) APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Nemours Children's Health Children's Hospital of Philadelphia Cincinnati Children's Hospital Beth Allen Real Talk: Eosinophilic Diseases Podcast   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of AstraZeneca, Bristol Myers Squibb, Sanofi, and Regeneron.   Tweetables:   “We've been very interested in what therapies may be effective for eosinophilic esophagitis, or EoE. The research that we've been doing … is trying to look at the right drug for the right patient, at the right dosing, etc.” — James Franciosi, MD    “The main benefit [of using PPIs as a treatment for EoE] is that you can reduce the inflammation that's occurring, [and] alleviate symptoms to make patients feel better.” — James Franciosi, MD   “Once you take the treatment away, whether that's eliminating foods, or taking medication, for the vast majority of people, the condition will come right back. That's also true with proton pump inhibitors.” — James Franciosi, MD   Featured speaker: Dr. James Franciosi Gastroenterology at Nemours Children's Health, Florida  

Yes, children can get multiple sclerosis. Children ages 12 and up are more typically affected and rarely before age 8. Awareness is essential for prompt diagnosis and treatment of pediatric-onset MS (POMS). Accurate diagnosis of multiple sclerosis in children requires screening for other conditions like MOG antibody-associated disease (MOGAD). Risk factors associated with higher rates of developing MS in kids include Epstein-Barr virus infection, genetic susceptibility, pesticide exposure, smoking (and secondhand smoke), low vitamin D, obesity and diet high in saturated fats. Multiple sclerosis in kids can be very active with frequent relapses and concerning MRI activity kids. Rapid use of highly effective treatment is important to preserve brain health including cognition. Completed and ongoing global pediatric trials are redefining care. Oral fingolimod, for example, reduced relapses by 82% compared to interferon beta-1a injections weekly. Thanks to treatment advancements, teens living with MS have a brighter future ahead of them. Barry Singer MD, Director of The MS Center for Innovations in Care, interviews Brenda Banwell MD, Chief of the Division of Neurology at the Children's Hospital of Philadelphia (CHOP) and Emmanuelle Waubant MD, PhD, Professor of Neurology , University of California San Francisco and Director of the UCSF Regional Pediatric Multiple Sclerosis Center.

This episode covers the following topics and more:The most common mental health issues that teenagers experience, and how this has this changed over the last few yearsHow parents can best support their teenagers who are struggling with mental health issues &  resources are availableChallenges that teenagers face in accessing mental health care, and what can be doneThe role social media plays in the mental health of teenagers, and how parents can help their children navigate online communication and social media useHow parents can differentiate between normal adolescent mood swings and more serious mental health issues & when to seek professional helpPractical strategies parents can use to "start the conversation" with their childrenThe most important things that parents and caregivers can do to help prevent mental health issuesHow parents can best communicate with their teenagers about mental health, and strategies for promoting open and honest communication within families and communitiesAbout Dr. Ken GinsburgKen Ginsburg, MD, MSEdFounder & Program Director, Center for Parent and Teen Communication at Children's Hospital of PhiladelphiaDr. Ginsburg is a physician, adolescent medicine specialist, and Professor of Pediatrics at Children's Hospital of Philadelphia (CHOP). Dr. Ginsburg is committed to preparing adults to be the kind of people that adolescents deserve in their lives. He supports local, regional, and national organizations in developing programs and policies that strengthen families and see young people through a strength-based lens. He speaks to parent, professional, and youth audiences nationally and internationally and is the author of 5 award-winning parenting books. His latest book, Congrats—You're Having a Teen! Strengthen Your Family and Raise a Good Person is out now from the AAP. Resources:#StandByTeensParentandteens.comStress Management PlanPreparing Teens to Seek Professional HelpReaching Teens: Strength-Based, Trauma-Sensitive, Resilience-Building Communication Strategies Rooted in Positive Youth Development, 2nd Edition 

This Episode Covers the Following Topics and More:Helping Young People Build ResilienceHow to Parent EffectivelyGiving Your Child a Deep Sense of SecurityProviding a Secure Home Base for Your ChildThe Definition of Resilience, and How  it Relates to the Physical and Mental Health of AdolescentsCommon Challenges that Adolescents Face Today, and How Building Resilience Can Help them Overcome ThemHow  Parents and Caregivers can Support Adolescents in Building Resilience & What Role They Play in this ProcessDeveloping Clear Boundaries How Social Media & Technology Impact the Resilience of Adolescents & Managing this InfluenceAbout Dr. Ken GinsburgKen Ginsburg, MD, MSEdFounder & Program Director, Center for Parent and Teen Communication at Children's Hospital of PhiladelphiaDr. Ginsburg is a physician, adolescent medicine specialist, and Professor of Pediatrics at Children's Hospital of Philadelphia (CHOP). Dr. Ginsburg is committed to preparing adults to be the kind of people that adolescents deserve in their lives. He supports local, regional, and national organizations in developing programs and policies that strengthen families and see young people through a strength-based lens. He speaks to parent, professional, and youth audiences nationally and internationally and is the author of 5 award-winning parenting books. His latest book, Congrats—You're Having a Teen! Strengthen Your Family and Raise a Good Person is out now from the AAP. Resources:Stress Management PlanPreparing Teens to Seek Professional HelpReaching Teens: Strength-Based, Trauma-Sensitive, Resilience-Building Communication Strategies Rooted in Positive Youth Development, 2nd Edition 

We have an exciting announcement, we are launching a Patreon! For those that are not familiar with Patreon, it's a platform that allows creators (like podcasters) to offer their followers more content, experiences, and even gifts. In order to provide what YOU want, please take 60 seconds to fill out our survey. By filling out the survey not only are you influencing what benefits we will offer, but you will be the first to know when we will launch! Can't thank you all enough for your listenership over the years, it's such a privilege to be able to launch a Patreon to engage with you all more. This week we're chatting about an emerging area of genetics, pharmacogenomics! Pharmacogenomics (PGx), one of the core elements of personalized medicine, is a field of research that studies how a person's genes affect how they respond to medications. Its long-term goal is to help doctors select the drugs and doses best suited for each person. Joining us for this conversation is Avni Santani PhD, FACMG, Chief Medical Officer of Veritas Genetics, a LetsGetChecked company, which delivers tailored at-home healthcare solutions to 300+ organizations. Dr. Santani holds a Master's degree in Medical Molecular Genetics from the University of Aberdeen and a PhD in Genetics from Texas A&M University. She holds specialty board certifications in Clinical Molecular Genetics and Clinical Cytogenetics from The Children's Hospital of Philadelphia (CHOP).On This Episode We Discuss:Pharmacogenomics and other similar termsThe state of genetic testing today and how it has changed in the last ten yearsWhy it is helpful to have pharmacogenomic testing information when figuring out the best drugs to prescribeSteps of drug metabolism that gene variants can affectHow gene variants can impact the drug response (drug reception, uptake, and breakdown)If testing can provide information on the dosage of drugs to prescribe and how this varies between peopleTypes of conditions/diseases where genetic testing results can be applied (behavioral health, cardiovascular health, and pain management) The role of testing in determining personal risk levels of becoming addicted to pain medicationsGenes that LetsGetChecked's myPGx test analyzesThe frequency at which gene variants found through this testing help narrow down which drug or dose to prescribeIf you want to learn more about pharmacogenomics, head over to the LetsGetChecked website. Be sure to follow our guest, Avni Santani, on Twitter; LetsGetChecked on Twitter, Facebook, LinkedIn, Instagram, YouTube; and VeritasGenetics on Twitter, Facebook, and Instagram.Stay tuned for the next new episode of DNA Today on March 31st, 2023, where we'll be diving deeper into pharmacogenomics (PGx) with James Fettig who will provide an overview of PGx for cancer! New episodes are released every Fridays. In the meantime, you can binge over 225 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. Episodes since 2021 are also recorded with video which you can watch on our YouTube channel. DNA Today is hosted and produced by Kira Dineen. Our social media lead is Corinne Merlino. Our video lead is Amanda Andreoli. Our outreach Intern is Sanya Tinaikar. Our Social Media Intern is Kajal Patel. And our Graphic Designer Ashlyn Enokian.See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNAToday.com. Questions/inquiries can be sent to info@DNAtoday.com. Surely you have heard of whole genome sequencing, but what about rapid and ultra-rapid whole genome sequencing? This is an emerging method of diagnosing genetic conditions for quick management. PerkinElmer Genomics offers this incredibly valuable test, which can be life saving for ill babies and kids. Learn more in our full episode (#226) with PerkinElmer Genomics. You can visit perkinelmergenomics.com for more information. (Sponsored)As a listener of DNA Today, you probably heard me talk about NIPT, non-invasive prenatal screening, that looks for extra or missing chromosome conditions during pregnancy. But did you know there is one that can also screen for recessive disorders (like cystic fibrosis) and fetal antigens? BillionToOne offers UNITY Screen, which does all this from one blood draw from a pregnant person. Visit unityscreen.com for more info. Listen to DNA Today Episode #224 Single Gene NIPT and #225 Fetal Antigen NIPT. (Sponsored)Juno Diagnostics has developed the next generation of non-invasive prenatal tests so that all pregnant people can access a higher standard of care. Juno Diagnostics is the only genetic testing company on the market that performs NIPS for common aneuploidies on blood samples from a finger stick instead of a traditional venous blood draw. That means you collect your sample on your own time, at home, and still have NIPS at a CLIA laboratory! Juno's Hazel™ NIPS screens for common chromosome variations seen in pregnancy, such as Down syndrome or trisomy 21, trisomy 13, and trisomy 18 – in addition to testing for fetal sex. You can order this test yourself, or have your healthcare provider order for you. Head to JunoDx.com and use the code "DNATODAY” for 10% off! Keep your eye out for our full episode interview with experts from Juno Dx including fellow genetic counselor Katie Sagaser and Dr. Allison Rodgers. In the meantime, check out JunoDx.com to learn more about Hazel and their other test Birch (which tests just for the sex of your baby). (Sponsored)

The birth of a child is a joyous occasion for an entire family.  But for the families of American babies born each year with congenital heart disease (CHD), it can also bring fear and uncertainty. Dr. Matthew O'Connor, attending cardiologist and the Medical Director of the Heart Failure and Transplant Program at Children's Hospital of Philadelphia (CHOP)has information about innovations in cardiac care that can save and improve the lives of children with heart disease worldwide.  

About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.Objectives:After listening to this episode, learners should be able to:Describe the rationale supporting and “ideal” patient that may benefit from various adjunctive therapies for PARDS:Corticosteroids Neuromuscular blockadeProne positioning Inhaled nitric oxide SurfactantAcknowledgement:Thank you to Dr. Nick Bartel for his help in creating learning objectives for this series.How to support PedsCrit:Please rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.Selected references:PMID: 10793162PMID: 25693014.PMID: 15269312PMID: 30361119PMID: 17426195PMID: 31112383PMID: 25647235PMID: 19001507PMID: 32043986.PMID: 15671432.Support the show

About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.Objectives:After listening to this episode, learners should be able toDescribe the rationale supporting and “ideal” patient that may benefit from various forms of non-conventional ventilation:Neurally adjusted ventilatory assist (NAVA)High-frequency oscillatory ventilation (HFOV)High-frequency percussive ventilation (HFPV)High-frequency jet ventilation (HFJF)Airway pressure release ventilation (APRV)Acknowledgement:Thank you to Dr. Nick Bartel for his help in creating learning objectives for this series.How to support PedsCrit:Please rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.Selected references:PMID: 10793162PMID: 25693014.PMID: 15269312PMID: 30361119PMID: 17426195PMID: 31112383PMID: 25647235PMID: 19001507PMID: 32043986.PMID: 15671432.Support the show

About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.Objectives:After listening to this episode, learners should be able to:Develop a mental model for titrating PEEP in PARDS with the acknowledgement of standardized ARDSnet PEEP-FiO2 tables. (High vs Low PEEP strategy? Is this applicable to children?)Understand the relationship between peak inspiratory pressure and plateau pressure in managing patients with PARDS in pressure control modes of ventilation.Develop a mental model for understanding various measures of respiratory support and understand their strengths, limitations, and value as markers of ventilator induced lung injury (peak inspiratory pressure, plateau pressure, driving pressure, mechanical power).Recognize the potential benefits of measuring esophageal pressure as a surrogate of transpleural pressure to titrate respiratory support in PARDS.Acknowledgement:Thank you to Dr. Nick Bartel for his help in creating learning objectives for this series.How to support PedsCrit:Please rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.Selected references:PMID: 10793162PMID: 25693014.PMID: 15269312PMID: 30361119PMID: 17426195PMID: 31112383PMID: 25647235PMID: 19001507PMID: 32043986.PMID: 15671432. Support the show

About our Guest:Dr. Yehya is a graduate of the University of California at Berkeley and the University of California at Los Angeles School of Medicine. After completing pediatrics training at Children's Hospital of Los Angeles, he completed his pediatric critical care fellowship at Children's Hospital of Philadelphia (CHOP), and joined the faculty after graduation in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.Dr. Yehya's research interests encompass all aspects of pediatric respiratory failure, with a particular emphasis on pediatric acute respiratory syndrome (ARDS) and mechanical ventilation. ARDS consists of sudden, severe flooding of the lungs in response to an inflammatory insult causing difficulty breathing, frequently requiring mechanical ventilation. Sepsis is a leading cause of ARDS in children. His long-term goal is better characterization of ARDS in children and to test therapies designed to improve outcomes. His NIH-funded work is assessing the utility of specific plasma biomarkers in pediatric ARDS, with subsequent proteomic characterization and testing in pre-clinical models. Dr. Yehya has several active studies involving biomarkers, clinical epidemiology, and pathophysiological mechanisms in the field of pediatric ARDS, and is involved in several multicenter and multinational collaborations.Objectives:After listening to this episode, learners should be able to:Understand the role of heated high-flow nasal cannula and non-invasive mechanical ventilation in the management of pediatric acute respiratory distress syndrome (PARDS).Recognize the potential for patient self-inflicted lung injury in PARDS.Recognize high-risk situations when non-invasive mechanical ventilation is relatively contraindicated in favor of intubation and mechanical ventilation.Acknowledgement:Thank you to Dr. Nick Bartel for his help in creating learning objectives for this series.How to support PedsCrit:Please rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.Selected references:PMID: 10793162PMID: 25693014.PMID: 15269312PMID: 30361119PMID: 17426195PMID: 31112383PMID: 25647235PMID: 19001507PMID: 32043986.PMID: 15671432.                                                            Support the show

The neonatal intensive care unit (NICU) is the hospital ward where no new parents ever hope to be. Though a safe haven for babies, the NICU becomes a temporary home to those who require immediate medical care, such as preterm or premature babies (born before 37 weeks of pregnancy), congenital anomalies (i.e., birth defects), and infections. According to the March of Dimes, a non-profit organization championing the fight against preventable maternal, preterm, and infant death, around 19.5% of babies are collectively born preterm in a given week in the United States. Premature birth can result in developmental delays and impairments in respiration, hearing, and vision, with data showing that it accounts for almost 36% of infant deaths from 2017-2019. Meanwhile, 3% of babies are affected by birth defects, accounting for 20% of infant deaths. What are the risk and preventable factors for preterm birth? What are the most frequent birth anomalies seen? How does the NICU team support babies and their parents and/or guardians when they leave the hospital?We are joined today by Dr. Kate Rubey, a board-certified neonatologist, NICU attending physician, and neonatal research fellow. She received her BA in Microbiology from Miami University in 2009, MA in Medical Science from Loyola University in 2010, MD from Rush Medical College in 2014, Pediatrics residency at the Children's Hospital of Wisconsin in 2017, and Neonatal-Perinatal Medicine fellowship at the Children's Hospital of Philadelphia (CHOP) in 2020. Outside the hospital, Dr. Kate is a current NIH-funded research scientist fellow focusing on pulmonary nanomedicine and a fount of pediatric education on social media, as recently featured on In the Know by Yahoo.Livestream Air Date: January 27, 2022Kate Rubey, MD, FAAP: IG @drkaterFriends of Franz: IG @friendsoffranzpod & FB @friendsoffranzpodChristian Franz (Host): IG @chrsfranz & YT Christian FranzThankful to the season's brand partners: Clove, BETR Remedies, Eko, Lumify, RescueMD, Medical School for Kids, Your Skincare Expert, Twrl Milk Tea

Clinical Child Psychologist and SiriusXM Mental Health Radio host Dr. Yamalis Diaz joins Zerlina on the show as part of our Mental Health Week!Dr. Diaz is a Clinical Child Psychologist and Clinical Assistant Professor of child and adolescent psychiatry at the NYU Child Study Center at NYU Langone Health. . She joined NYU in 2011, after receiving her doctorate in clinical psychology from the University of Maryland - College Park (2009) and completing a 2-year post-doctoral fellowship at The Children's Hospital of Philadelphia (CHOP). Dr. Diaz specializes in behavioral and parenting interventions for children with ADHD and disruptive behavior disorders. In addition to this area of specialty, Dr. Diaz developed and teaches an undergraduate course as part of the Child & Adolescent Mental Health Studies minor at NYU, entitled twentysomething, though which she has developed additional expertise in the development of young adults. Dr. Diaz regularly shares her expertise through various media channels, including on-air interviews with Diane Sawyer as part of a 20/20 primetime special entitled Screentime and the Emmy-award winning special Protect Our Children: Coping, Stress, & Moving Forward on ABC. She appeared on the CBS Morning Show with Gayle King to help launch the award-winning documentary about ADHD, The Disruptors, in which she was featured as an ADHD expert.

In many healthcare facilities, Sterile Processing departments fall under the reporting structure of perioperative services. The same cannot be said at the Children's Hospital of Philadelphia (CHOP). The Central Processing department at this facility broke the mold when it joined forces with Supply Chain and created a new reporting structure within their surgical services. On this week's Beyond Clean special release, we're sharing an exclusive interview from the 2019 HPN SPD Department of the Year award winner, CHOP's Robert Silverstein, Senior Director, Central Processing and High-Level Disinfection/Sterilization, from our "Conference of Champions" event earlier this year.    Join us for this interview as we hear from Robert about the benefits his department has experienced since making this structural change to report to & through Supply Chain. From the optimization of preference cards and supply chain management to the significant improvement to OR “On Time” starts, this reporting structure is certainly proven to be effective.  Gather around with your favorite inventory specialist and tune in for this collaborative discussion! Each "Conference of Champions" special release episode is individually approved for 1 CE, so once you finish this interview, you can download your CE certificate immediately by passing the short quiz linked below each week.  For access to this CE quiz and over 300 other free CE credits, visit our CE Credit Hub: http://www.beyondclean.net/ce-credit-hub

This week we have a surprise treat - a conversation with Jonathan's twin brother, Matt. He discusses his energetic commitment to mentoring and grant-writing workshops. They share their genetics, but also a desire to “help scientists do better science”Matthew comments on the usefulness of healthy competition in scienceMatt compares the joy of running a lab to cooking in the kitchenHe loves the flexibility of science and constantly stimulated by interactions with colleagues and young scientists and new ideasMatt makes a strong argument for peer-to-peer mentoring, cascade mentoring and seizing constant casual mentoring opportunitiesHe comments on the advantages of going to a small lab for graduate school and he advises students to look carefully at the type of scientific questions, the environment of the lab and the chemistry of the PI/mentor relationshipMatt describes his pioneering Grant Proposal Success (GPS) grant-writing program and the importance of collective, grant-writing communities. Matt dissects the grant structure and tells us what funding committees are looking forHe suggests that staggering projects and having work at different stages can help to integrate life and manage the labHe mentioned these institutions :  University of Leeds, UK : https://www.leeds.ac.uk/University of Pennsylvania : https://www.upenn.edu/Children's Hospital of Philadelphia (CHOP) : https://www.chop.edu/National Institutes of Health (NIH) : https://www.nih.gov/Salk Institute for Biological Studies : https://www.salk.edu/University of California San Diego : https://ucsd.edu/To find out more about Matt visit his website or follow him on Twitter :https://twitter.com/WeitzmanLabhttps://www.chop.edu/doctors/weitzman-matthew-dhttps://pathology.med.upenn.edu/department/people/517/matthew-d-weitzman30 Second Genetics : https://www.amazon.com/30-Second-Genetics-revolutionary-discoveries-explained/dp/1782405097To find out more about Renaud :Twitter : https://twitter.com/LePourpreLinkedIn : https://www.linkedin.com/in/renaudpourpre/To find out more about Jonathan :Twitter : https://twitter.com/EpigenetiqueLinkedIn : https://www.linkedin.com/in/jonathanweitzman/%20To learn more about the soundtrack :Music by Amaria - Lovely Swindlerhttps://soundcloud.com/amariamusique/https://twitter.com/amariamusique

Breaking into a creative field, whether you choose to be self-employed or not, can really leave you feeling like you're up the creek without a paddle. Who are you supposed to talk to, and when? Also, where do you find them? What are you supposed to do in the meantime until things...happen? And once you start doing that thing, how you do know when to stop? We talked about it all at this panel discussion I moderated with three dynamic young artists, Brendan Keen, Mariel Capanna, and Brittany Bennett, about navigating the difficult transition from school to the working world. Each of them is following a unique path, and has tons to share about what they did wrong...and right! About our guests Brendan Keen https://www.brendankeenstudio.com/ Brendan Keen is an artist and fabricator currently based in West Philadelphia. He was a transfer student at PAFA, where he majored in sculpture. He graduated with a BFA 2012, and was awarded the William Emlen Cresson Memorial Travel scholarship, which meant he stayed a fifth year at PAFA and received a certificate in 2013. When he finished school, he joined the West Philadelphia-based arts collaborative studio and workshop, the Philadelphia Traction Company. Along with the other artists at Traction, he exhibited his sculpture and collaborative works in Philadelphia and San Francisco. For the past eight years Brendan has worked full time as a self-employed Artist and fabricator, creating sculptural installations for public and private clients, including the Logan hotel, the W hotel, the Discovery Center, and private residences. In between jobs, Brendan travels whenever possible, including across Western Europe and around Iceland via bicycle, and most recently across the U.S. in a DIY sprinter camper van. Mariel Capanna https://marielcapanna.com/ Mariel Capanna is a fine artist specializing in fresco who graduated with a BFA from PAFA 2012, and she was awarded the William Emlen Cresson Memorial Travel scholarship, which means she spent an extra year at PAFA and was awarded a certificate in 2013. She received her MFA from Yale School of Art in 2020. She attended Skowhegan School of Painting and Sculpture in 2017. She's exhibited many places, including Adams and Ollman (Portland), Central Park (Los Angeles), Gross McCleaf Gallery (Philadelphia), and Good Weather (North Little Rock), COOP (Nashville) and at the Bowtie Project (Los Angeles). And has been the recipient of numerous residencies and fellowships (in addition to the Cresson): the 2019 Robert Schoelkopf Memorial Traveling Fellowship Recipient, the 2018 Haverford College VCAM Philadelphia Artist-in-Residence, a 2016 Tacony LAB Artist-in-Residence, a 2014 Independence Foundation Visual Arts Fellow, the Guapamacátaro Arts & Ecology Residency and The Mountain School of Art in 2016. Mariel currently serves as a Mellon Postdoctoral Fellow in Studio Art at Williams College, and a Fresco Instructor at Skowhegan School of Painting and Sculpture. Her ongoing project Little Stone, Open Home, with Good Weather is a long-term and perpetually changing fresco in a single-car garage in North Little Rock, Arkansas. Brittany Bennett https://bennettbc.wixsite.com/rad-river https://www.streamstudioschop.com/ https://www.brittanycbennett.com/ Brittany Bennett is a medical illustrator who graduated from the joint PAFA/PENN program in 2014. At PAFA, Brittany focused on academic oil painting and graphite drawing. Her work from this time is the result of meticulous observation of textures in nature and a celebration of details. After graduating, she completed a graduate program for Medical and Biological Illustration at Johns Hopkins. She currently works at the Children's Hospital of Philadelphia (CHOP), where half her week is in Stream Studios servicing the hospital network at large, and the other half she runs RIVER: a medical illustration service just for the Radiology Department. She is an artist with training in biology, anatomy, and visual communication who creates didactic illustrations and other visual aids. Brittany works with medical professionals at CHOP to produce patient education materials, figures for scientific literature, illustrated surgical training guides, 3D anatomical models, and more.

The Rich Zeoli Show- Hour 1: 3:05pm- While speaking with Mike Jerrick on FOX29, Democrat candidate for U.S. Senate John Fetterman said that he will, unsurprisingly, not withdraw from the race over concerns for his health. Fetterman also continued to insist he has “always been” a supporter of fracking in Pennsylvania—despite a 2018 interview where he ardently stated he opposed it. 3:15pm- McClatchy DC's David Catanese warned that voters in Pennsylvania should not expect election results in the state's U.S. Senate race right away—estimating that tallying mail-in ballots, and subsequently declaring a winner, could take several days. 3:30pm- On Tuesday's episode of The View, Whoopi Goldberg suggested that Fox News' rhetoric is at least partially responsible for the assault on Paul Pelosi, husband of Speaker of the House Nancy Pelosi.  3:40pm- Michael Greer—President & CEO of the Pennsylvania Family Institute—joins the show to discuss a new report alleging that since Tom Wolf became Governor of Pennsylvania, the state has spent $16.7 million in tax-payer money on child sex reassignment surgeries. During a Pennsylvania House Hearing in 2020, a representative of the gender clinic at Children's Hospital of Philadelphia (CHOP) explained there was no age limitation for gender reassignment surgery. 

The Sixth Sense: Joe Biden Sees Dead People…And Disastrous Polling for Dems! The Rich Zeoli Show- Full Show (11/02/22) 3:05pm- While speaking with Mike Jerrick on FOX29, Democrat candidate for U.S. Senate John Fetterman said that he will, unsurprisingly, not withdraw from the race over concerns for his health. Fetterman also continued to insist he has “always been” a supporter of fracking in Pennsylvania—despite a 2018 interview where he ardently stated he opposed it. 3:15pm- McClatchy DC's David Catanese warned that voters in Pennsylvania not to expect election results in the state's U.S. Senate race right away—estimating that tallying mail-in ballot, and subsequently declaring a winner, could take several days after the election. 3:30pm- On Tuesday's episode of The View, Whoopi Goldberg suggested that Fox News' rhetoric is at least partially responsible for the assault on Paul Pelosi, husband of Speaker of the House Nancy Pelosi.  3:40pm- Michael Greer—President & CEO of the Pennsylvania Family Institute—joins the show to discuss a new report alleging that since Tom Wolf became Governor of Pennsylvania, the state has spent $16.7 million in tax-payer money on child sex reassignment surgeries. During a Pennsylvania House Hearing in 2020, a representative of the gender clinic at Children's Hospital of Philadelphia (CHOP) explained there was no age limitation for gender reassignment surgery.  4:05pm- According to a report from The Boston Globe, a mere 2.4 million tons of the 51 million tons of plastic discarded in the United States annually is properly recycled. In response to the statistic, Greenpeace USA referred to recycling plastic as a “myth.” Dharna Noor writes, “many plastics that consumers think they are recycling never make it through a recycling process.” 4:15pm- While promoting her new book at London's Royal Festival Hall, climate activist Greta Thunberg suggested that the adoption of a non-Capitalist economic system is necessary to resolve the “climate crisis.”  4:35pm- During her Wednesday press briefing, White House Press Secretary said “mega MAGA Republicans” do not respect democracy—suggesting that their rhetoric leads to violence. Fox News' Peter Doocy asked Jean Pierre if the Biden administration believes Americans who vote for Republicans are a threat to democracy.  4:40pm- Despite receiving an open letter with over 600 signatures objecting to their decision, Penguin Random House has vowed to publish a book authored by Supreme Court Justice Amy Coney Barrett—scheduled to be released in 2023. According to National Review, the open letter accused Penguin Random House of “the destruction of human rights with obscene profits.” 4:50pm- In a recent opinion editorial, the Washington Post's Eric Wemple conceded the paper should have defended former New York Times editor James Bennet when he was unfairly criticized for publishing an opinion piece written by Senator Tom Cotton (R-AR). 5:00pm- Linda Kearns—Attorney for the Public Interest Legal Foundation—joins The Rich Zeoli Show to talk about the Pennsylvania Supreme Court's ruling that election officials can not count mail-in ballots that are incorrectly dated. Learn more about election integrity at: www.lindakearnslaw.com  5:20pm- While speaking at a Florida campaign rally for Senate candidate Val Demings and Gubernatorial candidate Charlie Crist, Joe Biden took credit for the recent dip in gas prices—but blamed Vladimir Putin and the oil industry for price increases. 5:45pm- Polling conspiracy theorist? MSNBC's Joy Reid claimed that Republican polling firms are “flooding” polling aggregate sites like Real Clear Politics and are, consequently, misleadingly predicting a “red wave” in the November 8thmidterm elections.  5:50pm- American Federation of Teachers President Randi Weingarten spoke at a campaign rally for Michigan Governor Gretchen Whitmer in Detroit—accusing Republican of being responsible adopting policies that are against the best interests of families and, instead, in alignment with oil companies who are “gouging consumers.”  6:05pm- Bad Opinion Editorial of the Day: In “Where Will This Political Violence Lead? Look to the 1850s”, Politico's Joshua Zeitz outlandishly compared modern Republicans to pro-slavery Southern extremist from the 1850s—concluding that “[i]f history is a guidepost, we are on the precipice of dangerous future in which politics devolves into a contest of force rather than ideas.” 6:30pm- Tom Szymanski—New Jersey Republican State Committee Executive Director—joins The Rich Zeoli Show to preview the November 8th midterm elections. Is a red wave coming to New Jersey? 6:55pm- Who Won Social Media? + Zeoli's Final Thought

Michael Greer—President & CEO of the Pennsylvania Family Institute—joins The Rich Zeoli Show to discuss a new report alleging that since Tom Wolf became Governor of Pennsylvania, the state has spent $16.7 million in tax-payer money on child sex reassignment surgeries. During a Pennsylvania House Hearing in 2020, a representative of the gender clinic at Children's Hospital of Philadelphia (CHOP) explained there was no age limitation for gender reassignment surgery. 

Countless studies have proven that employees want their employer to offer workplace well-being programs. In this episode, host Peter Panageas invites Vicki Amon, HR Program Manager of Well-being at Children's Hospital of Philadelphia (CHOP) and Joselito Huertas, who leads IBX's onsite and virtual fitness programs in his role at Exos. The two give great insights into what makes a successful workforce well-being program, how they had to shift as a result of the pandemic, and their personal experiences with health and wellness.

Celebrating 5 years of TopMedTalk at 'Anesthesiology'; the Annual General Meeting of the American Society of Anesthesiologists (ASA). Here we focus upon The Anesthesia Patient Safety Foundation (APSF). This piece is presented by Desiree Chappell and Monty Mythen with their guests JW Beard, Chief Medical Officer of GE Patient Care solutions, GE Healthcare, APSF Board of Directors and Jeffery Feldman, Attending Anesthesiologist, Children's Hospital of Philadelphia (CHOP) and Professor of Clinical Anesthesiology at the Perelman School of Medicine, University of Pennsylvania, APSF Board of Directors. The educational resources mentioned in this piece are here: https://www.apsf.org/apsf-technology-education-initiative/ The APSF website is here: www.apsf.org We spoke previously to The Anesthesia Patient Safety Foundation in 2019 here: https://www.topmedtalk.com/asa-2019-anesthesia-patient-safety-foundation-mark-warner/ We also consulted them during our coverage of the COVID-19 crisis: https://www.topmedtalk.com/the-anesthesia-patient-safety-foundation-covid-19/ TopMedTalk is very proud to be partnered with the American Society of Anesthesiologists® at ANESTHESIOLOGY® 2022. Now in our fifth year TopMedTalk is bringing you our most comprehensive and extensive coverage of the largest gathering of anesthesiologists in the world! This audio is presented to you "as live" - if you'd like to see our coverage as it happens go now to: https://live.topmedtalk.com/ TopMedTalk is provided to you for free; if you want to help support our work and help give these conversations a wider audience please like and subscribe (if and where possible) before sharing it on your social media. TopMedTalk can be found on YouTube here: https://www.youtube.com/channel/UC-HYQmeIwcFCYO1hoQ8jShQ We are on Twitter here: https://twitter.com/topmedtalk We are on LinkedIn here: https://www.linkedin.com/company/topmedtalk We are on Facebook here: https://www.facebook.com/TopMedTalk1/

Megan Robinson specializes in dietary and nutritional health in athletes with diabetes. Megan will discuss the nutritional challenges athletes with type 1 diabetes endure and how to build better nutritional health. Megan will explain how diabetes affects the athletes' train. Megan Robinson a registered dietitian and nutritionist (RDN) since 1994 has worked at The Children's Hospital of Philadelphia (CHOP) for the past 20 years. She is a Board-Certified Sports Dietitian and Certified Diabetes Educator specializing in sports nutrition and diabetes education. Megan also has a private practice in sports nutrition where she works with individuals to enhance their athletic journey through nutritional health. “[M]aking sure that they are getting enough nutrition for recovery as well. ” Question of the Day:  How has diabetes changed the way you train? This Episode you will Learn: Fueling the body for exercise and recovery Managing Blood sugar Is there a best time to exercise? Connect with Megan: Website  Instagram Facebook LinkedIn Connect with Yumlish: Website Instagram Twitter Facebook LinkedIn YouTube Key Points: [00:00:00] Intro with Shireen! [00:00:46]  Welcome Megan [00:01:17] How running lead to sports nutrition [00:04:27]  Understanding type 1 diabetes in athletes [00:06:00] Exercising effects on blood sugar [00:09:00]Competitive training vs non-competitive [00:13:08] Fueling the body for sports [00:16:32] Healthy protein-rich snacks [00:20:22] Connect with Megan [00:20:52] Outro with Shireen! --- Send in a voice message: https://anchor.fm/yumlish/message

Alex dives into the biggest medical experiment of the 20th Century: the development of the polio vaccines and the story of rivalry between its creators, Drs. Albert Sabin and Jonas Salk. A disease that was terrorizing parents all over the United States, the polio virus changed American medical history. We sit down with four amazing medical experts to discuss the polio crusade and its lessons for our current vaccine debates while analyzing the efforts of Dr. Albert Sabin from Cincinnati, Ohio and his oral polio vaccine that helps to nearly rid the world of this terrible virus. Dr. Paul Offit joins the show to discuss the terror that was the polio epidemic in the first half of the 20th Century and how America ultimately took the experimental vaccines in overwhelming numbers. Offit, from Children's Hospital of Philadelphia (CHOP) and the FDA's Vaccine Advisory Board has written extensively on the polio virus. Dr. Offit's new book You Bet Your Life (2021) discusses how there's inherent and very real risk involved in all medical innovations in our history. Polio and COVID-19 are no exception. Paul discusses the "Cutter Incident" in 1955, which stopped the polio vaccination process and his thoughts on vaccine skepticism in modern times. Buy Dr. Offit's new book here: https://www.amazon.com/dp/B08S3DL19Y We're joined by Brandy Schillace, science historian and author, to discuss the rivalry between Albert Sabin and Jonas Salk and why polio becomes such a problem for middle class America in the 1950s. Brandy teaches us about the importance of the messaging in the success of the polio vaccine rollout and its stark differences as a case study compared to the COVID vaccine rollout. Brandy's new book Mr. Humble and Dr. Butcher (Simon & Schuster 2021) can be purchased here and it's a truly fantastic read. https://www.simonandschuster.com/books/Mr-Humble-and-Dr-Butcher/Brandy-Schillace/9781982113780 Michael Flamm, professor of history at Ohio Wesleyan University, joins the program for the first and likely not the last time. Professor Flamm is the creator of How 1954 Changed the World on Audible.com and he joins the program to discuss "the greatest public health experiment" in US history up until that time. Professor Flamm highlights the careers of Sabin and Salk, their epic rivalry and how the Greatest Generation embraced the polio vaccine despite the uncertainties. Dr. Randy Sharma joins the program to discuss the effects of the polio virus on its child victims in the 1940s and 50s, things like the terrible solitude of the "iron lungs" and Sabin's early vaccine trials in Chillicothe and Cincinnati, Ohio. We're proud to be part of the Evergreen Podcast Network. Go to www.evergreenpodcasts.com for our show and dozens of other great podcasts. Follow us on Facebook, Instagram and Twitter. Don't hesitate to reach out to Alex by email at ohiovtheworld@gmail.com with a future show idea or to buy one of our great Ohio v. the World t-shirts. Learn more about your ad choices. Visit megaphone.fm/adchoices