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2 episodes with matthew state
2 episodes with matthew state
2 episodes with matthew state
The State of the Church 2025 (Matthew 28)
2025.01.05 Matthew State of The Church by Pastor Stephen Woodard
Neurogeneticists are modern day astronauts, taking us into inner space instead of outer space to explore the undiscovered neurons and networks in our brains. They are utilizing advances in genome sequencing to better grasp the cause of brain and nerve disorders, both to improve treatment, and to reduce stigma around these conditions. “When I started out in the field and started my laboratory, we were stymied in terms of identifying genes with any confidence that were contributing to psychiatric disorders in childhood. And that's despite tons of evidence that genes play a really important role in most of the disorders that arise in childhood. They're not faint. They don't dictate everything. But there's tons of evidence that they play an important role. But it was a really hard problem. And we had not figured out–and frankly, we didn't have the technology to reliably identify genes that were playing a major role in these disorders. And so I started a lab to see whether or not we could do that… after the turn of millennium, around 2007, 2008, we were one of the first labs to be able to identify with confidence, [a] specific gene playing a role in common forms of autism.” - Matthew State, MD, PhD Matthew State MD, PhD is the Oberndorf Family Distinguished Professor of Psychiatry and Behavioral Sciences, Chair of the Department of Psychiatry and Behavioral Sciences (DPBS), President of the Langley Porter Psychiatric Hospital and Clinics, and member of the Weill Institute for Neurosciences at the University of California, San Francisco. He is a child and adolescent psychiatrist and human geneticist. Over the past 20 years, his laboratory has contributed to major advances in the genetics and biology of developmental neuropsychiatric disorders, including autism spectrum disorder (ASD) and Tourette disorder (TD). Under his leadership, the UCSF DPBS has championed collaboration across the neurosciences at UCSF and pursued a major expansion of research, clinical services and advocacy, including overseeing the construction of the Nancy Friend Pritzker Psychiatry Building and the Joan and Sanford I Weill Neurosciences Building. He has championed multiple initiatives at the intersection of mental health and diversity, equity and inclusion, human rights, homelessness, and climate change. He has been the recipient of numerous awards including a Distinguished Citizen Award from the Commonwealth Club of San Francisco, the Ruane Prize from the Brain and Behavior Research Foundation, and the Rhoda and Bernard Sarnat International Prize in Mental Health from the US National Academy of Medicine. He was elected to membership in the National Academy of Medicine (NAM) in 2013. Join Marjorie Morrison and Patrick J. Kennedy for an in-depth discussion with Dr. State on our broken mental health system and how advances in genetics contribute to fixing it. If you enjoy this podcast, be sure to follow or subscribe wherever you are listening, and share the show with your colleagues and friends. You can also subscribe to our YouTube Channel here, https://www.youtube.com/c/PsychHub. Future Of Mental Health is a Psych Hub Podcast and is for educational purposes only. Visit https://psychhub.com to dig deeper and access the world's most comprehensive platform for behavioral health education. Follow us on Social Media Twitter: https://twitter.com/FOMHshow Instagram: https://www.instagram.com/psychhubeducation YouTube: https://www.youtube.com/c/PsychHub
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively anti-racist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively antiracist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively antiracist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively antiracist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively antiracist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively antiracist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
The race equity movement has left us with greater awareness of the urgent need for changes in the way we interact and run our businesses and institutions. This discussion features a frank discussion on what one psychiatry department has done to address interpersonal and systemic racism, as well as insight from an expert on a compassion-based approach for insightfully seeing and discussing race, and being actively anti-racist. Panelists: Rhonda Magee, JD, Professor of Law, University of San Francisco; Michelle Porche, EdD, Associate Adjunct Professor, UCSF Dept. of Psychiatry and Behavioral Sciences; Matthew State, MD, PhD, Oberndorf Family Distinguished Professor and Chair, UCSF Dept. of Psychiatry and Behavioral Sciences. Moderated by Elissa Epel, PhD, Vice Chair for Adult Psychology, UCSF. Series: "Emotional Well-Being in Times of Crisis" [Public Affairs] [Health and Medicine] [Show ID: 37477]
Join us for this special program in The Commonwealth Club's series recognizing recipients of The Club's Distinguished Citizen Award. Tonight's honorees are committed to the improvement of mental health in the Bay Area and the nation. This program will particularly honor the work of the University of California, San Francisco (UCSF), for its innovation in mental health, and will salute UCSF Health Executive Council Member John Pritzker; Psychiatry and Behavioral Sciences Department Chair Dr. Matthew State; Neurological Surgery Chair Dr. Edward Chang; and Dr. Lisa Fortuna, chief of psychiatry and vice-chair at Zuckerberg San Francisco General Hospital/UCSF. John Pritzker is chairman of the John Pritzker Family Fund and is well known for his commitment to mental health, serving on the Executive Council of UCSF Health and supporting The Commonwealth Club's speaker series on mental health, dedicated in memory of his sister, Nancy Friend Pritzker. Mr. Pritzker is also a significant supporter of UCSF's Department of Psychiatry and Behavioral Sciences, in particular the department's research, faculty, clinical care and training. He is passionate about reducing stigma, and to ensuring the availability and accessibility of mental health care. His charitable work on this issue has been aimed at supporting efforts to reduce mental health stigma at the individual, community and systems levels. Come for this tribute to the renowned UCSF Medical Center and its groundbreaking work in advancing mental health for all. SPEAKERS John Pritzker Chairman, John Pritzker Family Fund; Member, UCSF Health Executive Council Matthew W. State M.D., Ph.D., Oberndorf Family Distinguished Professor of Psychiatry; Chair, Department of Psychiatry and Behavioral Sciences, UCSF; President, Langley Porter Psychiatric Hospital and Clinics; Executive Director, UCSF Child, Teen and Family Center Edward Chang M.D., Joan and Sanford I. Weill Chair, Department of Neurological Surgery, Jeanne Robertson Distinguished Professor, Weill Institute for Neurosciences, University of California, San Francisco Lisa Fortuna M.D., MPH, Chief of Psychiatry and Vice-Chair, Zuckerberg San Francisco General Hospital/UCSF Michael Krasny Retired Host, KQED "Forum"—Moderator In response to the COVID-19 pandemic, we are currently hosting all of our live programming via YouTube live stream. This program was recorded via video conference on May 13th, 2021 by the Commonwealth Club of California. Learn more about your ad choices. Visit megaphone.fm/adchoices
Join us for this special program in The Commonwealth Club's series recognizing recipients of The Club's Distinguished Citizen Award. Tonight's honorees are committed to the improvement of mental health in the Bay Area and the nation. This program will particularly honor the work of the University of California, San Francisco (UCSF), for its innovation in mental health, and will salute UCSF Health Executive Council Member John Pritzker; Psychiatry and Behavioral Sciences Department Chair Dr. Matthew State; Neurological Surgery Chair Dr. Edward Chang; and Dr. Lisa Fortuna, chief of psychiatry and vice-chair at Zuckerberg San Francisco General Hospital/UCSF. John Pritzker is chairman of the John Pritzker Family Fund and is well known for his commitment to mental health, serving on the Executive Council of UCSF Health and supporting The Commonwealth Club’s speaker series on mental health, dedicated in memory of his sister, Nancy Friend Pritzker. Mr. Pritzker is also a significant supporter of UCSF's Department of Psychiatry and Behavioral Sciences, in particular the department's research, faculty, clinical care and training. He is passionate about reducing stigma, and to ensuring the availability and accessibility of mental health care. His charitable work on this issue has been aimed at supporting efforts to reduce mental health stigma at the individual, community and systems levels. Come for this tribute to the renowned UCSF Medical Center and its groundbreaking work in advancing mental health for all. SPEAKERS John Pritzker Chairman, John Pritzker Family Fund; Member, UCSF Health Executive Council Matthew W. State M.D., Ph.D., Oberndorf Family Distinguished Professor of Psychiatry; Chair, Department of Psychiatry and Behavioral Sciences, UCSF; President, Langley Porter Psychiatric Hospital and Clinics; Executive Director, UCSF Child, Teen and Family Center Edward Chang M.D., Joan and Sanford I. Weill Chair, Department of Neurological Surgery, Jeanne Robertson Distinguished Professor, Weill Institute for Neurosciences, University of California, San Francisco Lisa Fortuna M.D., MPH, Chief of Psychiatry and Vice-Chair, Zuckerberg San Francisco General Hospital/UCSF Michael Krasny Retired Host, KQED "Forum"—Moderator In response to the COVID-19 pandemic, we are currently hosting all of our live programming via YouTube live stream. This program was recorded via video conference on May 13th, 2021 by the Commonwealth Club of California. Learn more about your ad choices. Visit megaphone.fm/adchoices
In the second lecture, Dr. Matthew State overviews the hunt for genes associated with autism and explains how studying de-novo rare mutations in the germline has advanced the understanding of the genetics of autism spectrum disorder (ASD). Studying a cohort of families with one affected individual and one unaffected sibling, they were able to map multiple genes involved in ASD. Because of the complexity of the developing brain, the same gene could act upon different regions of the brain at different times during development. Therefore, after identifying genes associated with ASD, they characterized the region and time during development where these genes are expressed and more likely to have an effect that is associated with ASD.
In the first lecture, Dr. Bryan King introduces the autism spectrum disorder (ASD) and defines the clinical criteria that characterizes ASD. Although there is no universal drug that is used to treat ASD, there are multiple medications used in the setting of autism. King outlines the different drugs used to treat the core behavioral features of autism as well as psychiatric disorders associated with autism (e.g. ADHD and anxiety), and discusses the challenges and problems with designing clinical trials to study drugs to treat ASD, specifically with the heterogeneity of the ASD population.
The application of the study of genetics and the use of big data to identify patterns of inheritance as well as de novo mutations has had a dramatic impact on the field of Autism Spectrum Disorder research, and it offers pathways to a greater understanding of biological mechanisms, even potentially treatments. Matthew State, chair of the department of psychiatry at University of California San Francisco, and his colleagues wrote a review paper in the journal Neuropsychopharmacology, called “Leveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders.” Have a listen to learn more! See acast.com/privacy for privacy and opt-out information.
UC San Francisco's Matthew State provides a fascinating account of how the explosion of access to genetic information has led to a much deeper understanding of Autism and the possibility of developing interventions to treat Autism and other impairments such as Schizophrenia and Epilepsy. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Health and Medicine] [Science] [Show ID: 31766]
UC San Francisco's Matthew State provides a fascinating account of how the explosion of access to genetic information has led to a much deeper understanding of Autism and the possibility of developing interventions to treat Autism and other impairments such as Schizophrenia and Epilepsy. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Health and Medicine] [Science] [Show ID: 31766]
UC San Francisco's Matthew State provides a fascinating account of how the explosion of access to genetic information has led to a much deeper understanding of Autism and the possibility of developing interventions to treat Autism and other impairments such as Schizophrenia and Epilepsy. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Health and Medicine] [Science] [Show ID: 31766]
UC San Francisco's Matthew State provides a fascinating account of how the explosion of access to genetic information has led to a much deeper understanding of Autism and the possibility of developing interventions to treat Autism and other impairments such as Schizophrenia and Epilepsy. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Health and Medicine] [Science] [Show ID: 31766]
UC San Francisco's Matthew State provides a fascinating account of how the explosion of access to genetic information has led to a much deeper understanding of Autism and the possibility of developing interventions to treat Autism and other impairments such as Schizophrenia and Epilepsy. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Health and Medicine] [Science] [Show ID: 31766]
Three fascinating presentations show how explorations into synaptic development and genetic mutation are revealing pathways to better interventions for neurological impairment, from Schizophrenia and Amblyopia to Autism. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Science] [Show ID: 31757]
Three fascinating presentations show how explorations into synaptic development and genetic mutation are revealing pathways to better interventions for neurological impairment, from Schizophrenia and Amblyopia to Autism. Series: "Influence of Early Experience on Adult Brain Organization and Function - Kavli Institute for Brain and Mind Symposium" [Science] [Show ID: 31757]
Vad kan vi egentligen lära oss av den enorma utvecklingen inom genetisk forskning? Lyssna på barnpsykiatern Matthew State, vid University of California, som berättar om hur vi idag kan göra saker som var helt otänkbara för några år sedan.
Risperidone, a drug used to reduce irritability in people with autism, was not as effective as estrogens in correcting autism-like behavior in a study on zebrafish. Matthew State of the University of California, San Francisco and a team of international scientists introduced a gene known to cause autism in humans into these fish. They found that estrogens completely stopped their nighttime hyperactivity, which is a symptom of autism. Risperidone also prevented this behavior, but it made the fish less active during the day. "It doesn't explain why risperidone works. What it did do, was say, that of the medications that we know are FDA-approved for autism, they also will correct some of the abnormalities that are a consequence of these mutations in zebrafish. What we’re hoping for is that if we find a point of biological convergence, that will help narrow in on really the critical aspect of biology that is potentially, a target for therapeutics."
Our ability to diagnose and treat disorders of the mind lags far behind other medical disciplines. For our latest episode, we talked to Dr. Matthew State about why this is the case, and discussed how his research into the genetics of autism is revealing promising paths to future treatments.
Autism is five times more common in boys than girls, and a recent study at the University of California, San Francisco suggests a possible explanation for what’s called the Female Protective Effect. Using zebrafish carrying a gene known to lead to autism in humans, researcher Matthew State found that estrogens, an important hormone in females, reversed autism-like behavior. "From our genetic studies, we’ve identified that genetic changes that lead to autism in girls, as a general proposition, are more numerous and carry larger effects than they do in boys. And what that suggests is that you need more of a disturbance in girls, in order to get the same outcome as you do in boys. If you knew what the protective factor was, you would understand not only something about the biology of autism, but you would also understand something about the biology of resilience to autism risk." State hopes these insights will eventually lead to ways to treat or prevent autism.
In this month's Cell Podcast, we learn about getting neural stem cells out of the lab and into the clinic, with Sally Temple (0:00), an important role for rare copy number variations in autism, with Matthew State and Michael Wigler (8:30), the dangers of midnight feasts for fruit fly fertility, with Amita Sehgal (18:04), and fitness costs and crosstalk in the evolution of host defense pathways, with Ruslan Medzhitov (24:32).
Dr. Matthew State covers the challenges of gene discovery in ideopathic Autism, rare versus common genetic variation, and shares some recent findings and a nod to the future of Autism genetics.
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