In this special edition of the Award-winning PRS Journal Club Podcast, Dr. Summer E. Hanson discusses a prospective, randomized comparison of different autologous fat graft processing techniques. The episode was recorded LIVE at PSTM 2022 in Boston, Massachusetts with a live audience. Moderated by 2022 PRS Resident Ambassadors Said Azoury, MD, Emily Long, MD, and Ronnie Shammas, MD. READ the articles discussed in this podcast as well as free related content from the archives: https://bit.ly/PRSJC_LivePSTM22 #PRSJournalClub
Decline in services sector activity moderated the most, according to S&P Global; Growth in business activity in the euro zone turns positive; 3M to cut 2500 jobs globally; Johnson & Johnson profits fall To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
Rachel Brosnahan and Creator Sabrina Jaglom dive into the process of bringing an audio drama to life -- from the development process to production and post-production -- in this exclusive conversation. Moderated by QCODE EVP of Production Sandra Yee Ling.
Moderated by: Axel Hoos, MD, PhD, CEO, Scorpion Therapeutics Panelists: Jonathan Fassberg, Vice Chairman of Healthcare Investment Banking, OppenheimerIrina Margine, PhD, Principal, Biotech Private Equity, Wellington ManagementAsthika Goonewardene, MBA, Managing Director, Senior Biotech Analyst, Truist SecuritiesGraig Suvannavejh, PhD, Managing Director, Equity Research Biopharmaceuticals & Biotechnology, Mizuho Securities USA Learn more about the IO360° Summit at www.io360summit.com
Join Leslie for this very special episode directly from LaFemme International Film Festival. Moderated by Debeorah Gilels from LA Media Consultants this is part 2 of a panel titled Independent Financing: From Bridge to Gap to Raising Capital.
This panel, first recorded at the 2022 IO360° Summit addressed: What are the risks and implications of investing in cell/gene therapy companies who have no clinical data from programs available?Venture company perspectives on what they are investing in and why? • What science needs to be seen in order to invest in either a startup or IPO?What are investors/pharma partners looking for and how does that inform what people should be doing?How do we think about partnerships between organizations? Moderated by: Michael Polansky, CEO, Parker Group Panelists: Mark Bonyhadi, PhD, Senior Advisor, Qiming Venture PartnersElaine Cheung, SVP, Corporate Strategy & Business Development, Lyell ImmunopharmaArjun Goyal, MD, MPhil, MBA, Co-founder and Managing Director, Vida Ventures Learn more about the IO360° Summit at www.io360summit.com
In our surprise final finalé episode, we bring you the audio recording from the Artist Talk for the Border is a Weapon Exhibition, moderated by Jose Diaz - the former Chief Curator at the Andy Warhol Museum. It took place February 22, 2022 over zoom to an audience of about 50-60 people. All artists were present except Daniela Cavazos Madrgial and Tereneh Idia who were not available that evening. At that point the exhibition The Border is a Weapon, curated by Gil Rocha at 937 Gallery in Pittsburgh, PA had been open almost a month and had been seen by thousands including the opening night that was packed and overflowing with people. This conversation flowed easily between the artists and Jose Diaz. It serves now as an important historic document of a show that continues to grow and travel, most recently it was shown at the Laredo Center for the Arts, summer 2022, and will continue to the University of Syracuse later in 2023. Enjoy! And thank you for being part of our Other Border Wall Podcast series. It has been a pleasure serving you in such creative and positive ways! For anyone interested in starting a podcast who has never done anything like this before, please seriously reach out to us. We believe in the power of art and collaboration and doing things that seem nearly impossible! Find more at otherborderwallproject.com --- Send in a voice message: https://anchor.fm/otherborderwall/message
Our topic in this episode is focused on inflation and the US economy, with special guest John Cochran, an economist and Senior Fellow at the Hoover Institution at Stanford University. Previously, John was a professor of finance at the University of Chicago Booth School of Business. John writes occasional op-eds for the Wall Street Journal and blogs as the Grumpy Economist at johncochrane.com, and he recently created a Coursera outline course called Asset Pricing, covering first year PhD asset pricing. He has a new book out this month entitled “The Fiscal Theory of the Price Level.” We hope you enjoy our conversation.
Join Leslie for this very special episode directly from LaFemme International Film Festival. Moderated by Debeorah Gilels from LA Media Consultants this is part 1 of a panel titled Independent Financing: From Bridge to Gap to Raising Capital.
In this special episode of the Auto Remarketing Podcast, we feature a panel discussion from Used Car Week with top analysts in auto retail. Moderated by Cherokee Media Group's Joe Overby, this panel includes Kevin Roberts of CarGurus, Zack Krelle of TrueCar, Karl Brauer of iSeeCars.com and David Greene of Cars.com.
Moderated by Senior Equity Strategist Linda Duessel, Senior Portfolio Managers Stephen DeNichilo and John Ettinger discuss where they see opportunities in the small-cap market. Special Guests: John Ettinger and Stephen DeNichilo.
In this special episode of the Auto Remarketing Podcast, we feature the High Performance Auto Auctions panel discussion from Used Car Week in November in San Diego. Moderated by Cherokee Media Group's Bill Zadeits, this panel featured: Tommy Rogers of BSC America, David Andrews of Dealers Auto Auction Group, Matt Trapp of Manheim, John Hammer of ADESA and Sawyer Walker of America's Auto Auction Group.
Q&A on the series Ginny & Georgia with showrunner/writer/executive producer Debra J. Fisher, creator/writer/executive producer Sarah Lampert, and actors Antonia Gentry and Brianne Howey. Moderated by Mara Webster, In Creative Company. Teenage Ginny and her family yearn to put down roots in a picturesque New England town after years on the run.
The Rich Zeoli Show- Hour 2: Speakership Vote #6: Kevin McCarthy has once again failed to get the 218 votes necessary to become Speaker of the House. Is it time for the Republican party to rally around a new candidate? Twitter Files Part 11: On Tuesday, investigative journalist Matt Taibbi released another series of Twitter files—this time documenting why the social media company allowed the intelligence community to suppress and moderate content, specifically references to a lab leak theory as the origins of COVID-19. The House of Representatives has adjourned until 8pm ET after six failed attempts to select a new Speaker. The Centers for Disease Control tweeted: “The best defense is a good offense! Defend yourself against blood clots…” Rich can't remember government agencies ever issuing blood clot warnings for young athletes in the past. After six failed votes to determine a Speaker of the House, are more Republicans willing to defect from Kevin McCarthy?
Q&A on the 95th Academy Award short listed short film All In Favor with director/writer/producer Santiago Requejo and executive producer Tono Escudero. Moderated by Mara Webster, In Creative Company. During a neighbors meeting, a landlord generates controversy over his new tenant's condition
Wednesday, January 4, 2023 - Prairie Public will be hosting a panel discussion at the Heritage Center on Sunday exploring the parallels between Bismarck history and that of Manzanar, California: namely, Japanese internment, Indigenous dispossession, and political/economic wrangling over water use and protections. Moderated by Alicia Hegland-Thorpe, the discussion will feature Dennis Neumann, the longtime archivist at United Tribes Technical College in Bismarck; and Erik Holland, the longtime education director with the State Historical Society of North Dakota. ~~~ Prairie Public Television Production Manager Barb Gravel joins us to preview the upcoming season of Prairie Musicians.
Film Roundtable is thrilled to welcome acclaimed cinematographers Jamie D. Ramsay SASC and Larkin Seiple.In this in-depth conversation with Matthew Woolf they talk about their careers, ambitions, and sacrifices and their approach to color, tone, and camera tests on their recent respective movies, Living, and Everything Everywhere All At Once.One of the great takeaways from this rich conversation is how cinematography can help art become more compelling and hopefully leaving the audience with a more memorable emotional experience.
Recorded live on Clubhouse, Monday, January 2, 2023 / Moderated by painter and Two Coats of Paint Publisher Sharon Butler, hosted by sculptor-professor Peter Dudek. Listen to a live discussion about the art exhibitions we missed in 2022. Is it possible for artists to see too many exhibitions? Featuring artists-writers Laurie Fendrich, Franklin Einspruch, Patrick Neal, and painters Louise Belcourt and Catherine Howe.
Q&A on the film Alice, Darling with actor Anna Kendrick. Moderated by Mara Webster, In Creative Company. Pushed to the breaking point by Simon, her psychologically abusive boyfriend, Alice rediscovers the essence of herself and gains some much-needed perspective while on vacation with two close girlfriends. However, Simon's vengeance is as inevitable as it is shattering, and once unleashed, it tests her strength, her courage, and the bonds of deep-rooted friendships.
An IAEA panel discussion at COP27 on how nuclear energy intersects with the lives of individuals and a diverse array of nations including Sierra Leone, Nigeria, Egypt, South Africa, the USA and Sweden. Moderated by: Mark Nelson, Managing Director, Radiant Energy Group Panelists: Seth Grae - American Nuclear Society - CEO, Lightbridge Corporation Heba Elkomey - International Youth Nuclear Congress - PhD Candidate at Claremit, Egyptian Atomic Energy Authority Amanda Mbhele - Women in Nuclear Young Generation - Nuclear Waste Projects Lead, Nuclear Energy Company of South Africa Alfred Mbayoh - International Youth Nuclear Congress - CEO and Founder LEOTech Sierra Leone Ia Aanstoot - Generation Atomic - Berzelius School, Linkoping, Sweden Abubakar Sadiq Aliyu -International Youth Nuclear Congress - PhD Candidate in Nuclear Physics, Ahmadu Bello University
This episode was recorded from a LIVE fireside chat on “Family Business in Taiwan: Challenges We Face” at a Curito event to showcase the Curito Connects series. Moderated by Jenn, this panel consists of Christina Huang (President of Manloy), John Chen (Vice Chariman and CEO, Gloria Hotel Group), and Winnie Chao (President of Ko Wen Educational Institute). The conversation covered challenges they faced personally and professionally, how they overcame them, what they learned and what advice they would give to others. (Recorded on March 27, 2022)About the Panelist:Christina Huang is the President of Manloy she has a background in teaching and arts administration. Her career was primarily in education and cultural institutions, she has since combined her passion for knowledge and visual communication with her leadership and management style at Manloy.John Chen is the vice chairman and CEO of Gloria Hotel Group. He established Hotel Quote, Hotel Proverbs, other Design Hotels and Gloria Outlets in Taiwan.Winnie Chao is the CEO of Kumon Education Taiwan, a passionate educator, and dedicated philanthropist. She is happily married with five kids, and resides in Taipei.Watch the entire episode on Youtube
Q&A on the Netflix series The Witcher: Blood Origin with showrunner Declan de Barra, and actors Sophia Brown, Laurence O'Fuarain, Francesca Mills and Huw Novelli. Moderated by Mara Webster, In Creative Company. Set more than a thousand years before the world of "The Witcher," seven outcasts in the elf world unite in a quest against an unstoppable power.
Welcome to a live session presented by BookFest / Festival du Livre Windsor 2022 featuring Luke Hathaway, David Ly and Sarah Yi-Mei Tsiang. Moderated by Windsor poet Dorothy Mahoney. Sarah Jarvis, wearing two hats as podcaster and president of Literary Arts Windsor, the charitable organization that runs BookFest, introduces the sessions.This was recorded live at Fionn MacCool's, Windsor, so there are background noises and the occasional dropping spoon. Occasional mature content. Luke Hathaway is a trans poet who teaches English and Creative Writing at Saint Mary's University in Kjipuktuk/Halifax. He has been before now at some time boy and girl, bush, bird, and a mute fish in the sea. His book Years, Months, and Days was named a best book of 2018 in The New York Times. He mentors new librettists as a faculty member in the Amadeus Choir's Choral Composition Lab, and makes music with Daniel Cabena as part of the metamorphosing ensemble ANIMA. His latest book is The Affirmations (Biblioasis, 2022.) http://biblioasis.com/brand/hathaway-luke/ David Ly is a writer and editor whose debut poetry collection, Mythical Man (Palimpsest Press, 2020), was shortlisted for the 2021 Relit Poetry Award. David is the poetry editor at THIS Magazine, part of the Anstruther Press editorial collective, and a poetry manuscript consultant with The Writers' Studio at SFU. Dream of Me as Water is his second poetry collection. https://palimpsestpress.ca/books/dream-of-me-as-water/ Sarah Yi-Mei Tsiang is the author of Grappling Hook (2022) with Palimpsest Press, Status Update (2013), which was nominated for the Pat Lowther Award, and the Gerald Lampert award winning Sweet Devilry (2011). Her work has appeared in Best Canadian Poetry (2013, 2021, 2023,) and Best of the Best Canadian Poetry. She has been both longlisted and shortlisted for the CBC poetry prize as well as shortlisted for the UK's Forward Award. She is the editor of the poetry collection, Desperately Seeking Susans (2013), the Poetry Editor for Arc Poetry Magazine, the Creative Director at Poetry in Voice, and teaches in both the UBC optional residency MFA program and the Vancouver Manuscript Intensive. She is also the author of eight children's books. https://sarahtsiang.com/Literary Arts Windsor would like to acknowledge the Ontario Arts Council, Canadian Heritage CAPF Fund, and the Canada Council for the Arts for funding our festival.
Q&A on the film Living with cast Bill Nighy and Aimee Lou Wood, director Oliver Hermanus, and screenwriter Kazuo Ishiguro. Moderated by Mara Webster, In Creative Company. A veteran civil servant receives a medical diagnosis that inspires him to move to the south coast and cram some fun into his remaining days. He meets a sunny young female colleague who seems to have the pep that had previously escaped him.
Q&A on the Netflix series Emily in Paris with actor Philippine Leroy-Beaulieu. Moderated by Mara Webster, In Creative Company. Chicago marketing executive Emily Cooper is hired to provide an American perspective at a marketing firm in Paris.
Q&A on the film Mindcage with director Mauro Borrelli. Moderated by Mara Webster, In Creative Company. When a copycat murderer strikes, Detectives Jake Doyle and Mary Kelly seek help from an incarcerated serial killer called the Artist. As Mary delves deep into the Artist's brilliant but twisted psyche, she and Jake get lured into a diabolical game of cat and mouse, racing against time to stay one step ahead of both criminals.
Q&A on the IFC Films movie Corsage with actor Vicky Krieps and writer & director Marie Kreutzer. Moderated by Mara Webster, In Creative Company. Faced with a future of strict ceremonies and royal duties, Empress Elisabeth of Austria rebels against her public image and comes up with a plan to protect her legacy.
A webinar organized by the Committee of Anti-Imperialists in Solidarity with Iran, leading up to International People's Tribunal on US Imperialism: Sanctions, Embargoes, Economic Coercive Measures The Tribunal will expose the effects of unilateral and multilateral sanctions on peoples and nations targeted by imperialism — and explore legal and political strategies to challenge these regimes of coercion. Donate to support the Tribunal: https://gofund.me/b67e2378 Watch the video edition on the CASI YouTube Channel https://solidarityiran.org/ Originally recorded: December 18, 2022 Speakers: Dr. Bikrum Gill | Professor in Political Science Department at Virginia Tech University; Dr. Corinna Mullin | Professor in Global Politics and Political Economy at City University of New York (CUNY); David Paul | Sanctions Kill; Eunha Jeong Wood | Nodutdol for Korean Community Development. Moderated by Charlotte Kates | International Coordinator of Samidoun & Member of the Steering Committee of the Tribunal
Episode 123: Spontaneous Bacterial Peritonitis. Kaitlen defines spontaneous bacterial peritonitis (SBP) and also explains the diagnosis and management. Written by Kaitlen Roy-Ross, MS4, Ross University School of Medicine. Moderated by Hector Arreaza, MD. Definition:An ascitic fluid infection with no obvious surgically treatable intra-abdominal source (bowel perforation, abscess, perforated ulcer). Commonly seen in patients with cirrhosis and ascites. Patients may have symptoms of fever, abdominal pain, abdominal tenderness, altered mental status, and hypotension.Etiology: The most common pathogens (75%) are gram-negative aerobic organisms. Klebsiellapneumoniae accounts for 50% of the cases. Gram-positive aerobic bacteria (Streptococcus pneumoniae or viridans group streptococcus) account for the remaining cases. Some report E. coli as the most common cause of SBP. Random information: in Korea, Aeromonas hydrophila is an important pathogen of SBP during the summer. Diagnosis: To diagnose SBP, a paracentesis should be performed to analyze the ascitic fluid prior to treating the patient with antibiotics.The ascitic fluid should be analyzed for the following: PMN (Polymorphonuclear cell) count: > or = to 250 cells/mm3 Aerobic and anaerobic culturesSerum ascites albumin gradient (serum albumin-ascitic albumin): this measures portal pressure.If the gradient is > 1.1 = portal HTN is present (cirrhosis, heart failure, large liver malignancy, alcoholic hepatitis, portal vein thrombosis) – SBP is likely.If the gradient is 6 mg/ suggests a gallbladder perforation. No SBP.Treatment:The treatment for spontaneous bacterial peritonitis is broad-spectrum antibiotics. Empiric treatment is indicated if a patient with ascites has any of the following:Temperature > 100 FAbdominal pain or tendernessAltered mental statusPMN in ascitic fluid > 250 (but if there is bacteria in ascitic fluid, start antibiotics stat)Alcohol-induced hepatitis*Important note: Patients on beta blockers should have them permanently discontinued prior to treatment for SBP as beta blockers are associated with worse outcomes. In one study, patients on beta blockers had a 58% increase in mortality risk compared to patients not treated with beta-blockers. Beta-blockers were also associated with higher rates of hepatorenal syndrome and longer lengths of hospital stay.1st line treatment- 3rd generation Cephalosporin Cefotaxime 2g IV Q8H (preferred) or Ceftriaxone 2 g per day2nd line treatment- Carbapenems. Usually reserved for patients with severe disease/critical illness.3rd line- Fluoroquinolones- Cipro 400 mg IV BID to patients with normal renal function. (Patients should not get this if they already receiving it prophylactically.)Duration of treatment:5 days, then re-assess the patient's PMN count:PMN 250 or greater than pre-treatment PMN count > look for a surgical source of infection.If PMN is > 250 but less than pre-treatment value, continue ABX for 48 more hours and then repeat paracentesis. Note: In general, ascitic fluid PMN count should be reduced by at least 25% after 48 hours of antibiotic therapy.Renal failure is the major cause of death in patients with SBP and develops in 30-40 % of the patients. We can decrease this risk by administering IV albumin. IV albumin should be given when the creatinine is > 1 mg/dl, the blood urea nitrogen is > 30 mg/dl, or the total bilirubin is > 4 mg/dl. Treatment with octreotide or midodrine is helpful if renal failure develops.Prevention:Antibiotic prophylaxis can be given to patients with risk factors for SBP. Some risk factors include prior history of SBP, variceal hemorrhage, or an ascites fluid protein concentration of
Q&A on the Netflix series The Recruit with actor & executive producer Noah Centineo, actor Laura Haddock, and creator & showrunner Alexi Hawley. Moderated by Mara Webster, In Creative Company. Follows a lawyer at the CIA who gets entangled in dangerous international power politics when a former asset threatens to expose the nature of her long-term relationship with the agency.
Q&A on the film Tár with writer/director/producer Todd Field, cinematographer Florian Hoffmeister, editor Monika Willi, composer Hildur Guðnadóttir, and re-recording-Mixer Deb Adair. Moderated by Mara Webster, In Creative Company. Renowned musician Lydia Tár is days away from recording the symphony that will elevate her career. When all elements seem to conspire against her, Lydia's adopted daughter Petra becomes an integral emotional support for her struggling mother.
Q&A on the Apple TV+ series Pachinko with actors Minha Kim and Jimmi Simpson. Moderated by Mara Webster, In Creative Company. Based on the New York Times bestseller, this sweeping saga chronicles the hopes and dreams of a Korean immigrant family across four generations as they leave their homeland in an indomitable quest to survive and thrive.
Q&A on the Apple TV+ series Mythic Quest with actor Charlotte Nicdao. Moderated by Mara Webster, In Creative Company. The team behind the biggest multiplayer video game of all-time is tasked with building worlds, moulding heroes and creating legends, but the most hard-fought battles don't occur in the game -- they happen in the office.
Q&A on The Northman with director & writer Robert Eggers, co-writer Sjón, cinematographer Jarin Blaschke, composer Robin Carolan, and composer Sebastian Gainsborough. Moderated by Mara Webster, In Creative Company. Prince Amleth is on the verge of becoming a man when his father is brutally murdered by his uncle, who kidnaps the boy's mother. Two decades later, Amleth is now a Viking who raids Slavic villages. He soon meets a seeress who reminds him of his vow -- save his mother, kill his uncle, avenge his father.
Q&A on The Northman with director & writer Robert Eggers, editor Louise Ford, production designer Craig Lathrop, and hair & make-up designer Maralyn Sherman. Moderated by Mara Webster, In Creative Company. Prince Amleth is on the verge of becoming a man when his father is brutally murdered by his uncle, who kidnaps the boy's mother. Two decades later, Amleth is now a Viking who raids Slavic villages. He soon meets a seeress who reminds him of his vow -- save his mother, kill his uncle, avenge his father.
Q&A on the Disney+ series Willow with actor Tony Revolori. Moderated by Mara Webster, In Creative Company. An unlikely group of heroes set off on a dangerous quest to places far beyond their home, where they must face their inner demons and come together to save their world.
Q&A on the Disney+ series Willow with actor Amar Chadha-Patel. Moderated by Mara Webster, In Creative Company. An unlikely group of heroes set off on a dangerous quest to places far beyond their home, where they must face their inner demons and come together to save their world.
Q&A on the film Triangle of Sadness with actor Dolly De Leon. Moderated by Lois Smith. A cruise for the super-rich sinks, leaving survivors, including a fashion model celebrity couple, trapped on an island.
Q&A on the film Honk for Jesus. Save Your Soul. with actor Regina Hall. Moderated by Mara Webster, In Creative Company. Proud first lady of a Southern Baptist megachurch, Trinitie Childs carries immense responsibility on her shoulders. After a scandal involving her husband, the church is forced to temporarily close, leaving Trinitie struggling to manage the aftermath. Now, she and her spouse must rebuild their congregation and reconcile their faith by all means necessary to make the biggest comeback that commodified religion has ever seen.
Evaluating single cell omics to understand the heterogeneity in immune and tumor cellsMulti-omic biomarkers for patient selection in solid tumor IO: is there a path to more personalized therapy?In an era of ‘targeted' therapies against cell-intrinsic mechanisms (e.g. PARP, NTRK, BRAF) and surface molecules (Nectin-4, HER2), is there a path forward for pan-tumor biomarkers, or is multi-tumor more likely to be the dominant development mechanism? Moderated by: Theresa LaVallee, PhD, VP, Translational Medicine and Regulatory Affairs, Parker Institute for Cancer Immunotherapy Panelists: Jared Lunceford, PhD, Distinguished Scientist, Biostatistics and Research Decision Sciences, Merck Research LaboratoriesAngel A Rodriguez, MD, Oncology Medical Director, NateraSamik Upadhaya, PhD, Research Analyst, Anna-Maria Kellen Clinical Accelerator and Venture Fund, Cancer Research Institute (CRI) Learn more about the IO360° Summit at www.io360summit.com
Q&A on the film The Woman King with screenwriter Dana Stevens. Moderated by Mara Webster, In Creative Company. In the 1800s, a group of all-female warriors protects the African kingdom of Dahomey with skills and fierceness unlike anything the world has ever seen. Faced with a new threat, Gen. Nanisca trains the next generation of recruits to fight against a foreign enemy that's determined to destroy their way of life.
Q&A on The Bob's Burgers Movie with writer & director Loren Bouchard, director Bernard Derriman, writer Nora Smith, and producer Janelle Momary-Neely. Moderated by Mara Webster, In Creative Company. A ruptured water main creates an enormous sinkhole right in front of Bob's Burgers, blocking the entrance indefinitely and ruining the Belchers' plans for a successful summer. While Bob and Linda struggle to keep the business afloat, the kids try to solve a mystery that could save their family's restaurant. As the dangers mount, these underdogs help each other find hope as they try to get back behind the counter.
December 7, 2022 Future of Chicagoland Transit: Funding, Fares, and Flexibility – Moderated by H.G. Chissell – Erin Aleman, Rep. Eva-Dina Delgado, Jacky Grimshaw, Leanne Redden City Club event description: Erin Aleman After progressing steadily in a variety of leadership roles at the local, regional, and state levels, Erin Aleman was appointed unanimously by the […]
This panel, first recorded at the 2022 IO360° Summit, reported on advances in achieving more diversity and inclusion in oncology clinical trials. Moderated by: Adrelia Allen, PharmD, Director, Clinical Trial Patient Diversity, Global Clinical Trial Operations, Merck Research Labs Panelists: Chétna Rao, PhD, Head of Site Strategy and Operations, BMSRobert Vonderheide, MD, DPhil, Director, Abramson Cancer Center, Perelman School of Medicine, University of PennsylvaniaKaren Peterson, Patient Advocate and Founder, Karen's ClubMichel Reid, Sr. Director and Head, Global Demographics & Diversity, Global Clinical, Delivery, Global Clinical Operations, R&D, GSK Learn more about the IO360° Summit at www.io360summit.com
In this explosive, never-before-heard episode, Evelyn and Alex discuss the trust and safety implications of the AI text-generator ChatGPT, the expansion of a cross-industry database for removing non-consensual intimate images from platforms, a legal challenge to a new online hate speech law in New York, and….. The Twitter Files, of course.
Episode 120: Immune Reconstitution Inflammatory Syndrome (IRIS) Abeda Faharti and Dr. Schlaerth present the definition, diagnosis, and treatment of IRIS. Moderated by Dr. Arreaza. Written by Abeda Farhati, MS4, Ross University School of Medicine. Editing and comments by Katherine Schlaerth, MD, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition.Have you heard of IRIS? No, not the color portion of our eyes. IRIS is short for Immune Reconstitution Inflammatory Syndrome. This condition occurs in immunocompromised patients with HIV/AIDS due to an overactive inflammatory response. In most cases, it occurs after initiating antiretroviral therapy (ART). To understand IRIS in HIV patients, we must first understand HIV.HIV.The Human Immunodeficiency Virus (HIV) infection was first reported in 1981. The virus attacks the immune system, destroying white blood cells called CD4+ T lymphocytes, which are part of our body's defense mechanism. These cells are also known as "helper T cells" and are responsible for destroying viruses, bacteria, and other germs that make us sick.When your CD4+ count is low, you are more likely to get serious infections from viruses, bacteria, and fungi, which usually do not cause problems in otherwise healthy individuals. These infections are called Opportunistic infections, and they can be deadly. To restore CD4+ T lymphocytes, HIV patients are started on ART to normalize their immune response to pathogens. As a result of these treatments, HIV patients' lives have been significantly improved and prolonged. [Comment by Dr. Arreaza: It is paradoxical, but some HIV patients are among the healthiest patients I have seen.]Despite this, no treatment is guaranteed to be without side effects. Increases in CD4+ T lymphocytes trigger the immune system to respond to any persisting antigen, regardless of whether it is fragments or intact organisms. As a result, a hyperinflammatory response may occur.Diagnosis.There are no established criteria for diagnosing IRIS. It is generally accepted that IRIS requires the worsening of an existing infection or an unrecognized, preexisting infection in the context of improved immune function. For a diagnosis to be made, most, if not all of the following features must be present:The presence of a low CD4 count (less than 100 cells) before initiating treatment with ART (Except IRIS secondary to preexisting TB infection can occur with CD4 counts >200 cells).The presence of an inflammatory condition, especially after ART is initiated.The absence of drug-resistant infection, bacterial superinfection, drug allergy, or other adverse drug reactions.The absence of patient noncompliance or reduced drug levels due to drug-drug interactions or malabsorption.Clinical Manifestations.IRIS can be presented in patients in 2 ways:Patient's with a preexisting infectious disease that has NOT been treated, getting paradoxically worse after initiating treatment with ART ---this is known as “unmasking IRIS” ORPatient's with a preexisting infectious disease that has been previously diagnosed and treated but regained capacity after treatment with ART, causing it to mount an inflammatory response – this is known as “paradoxical IRIS.”In summary: Unmasking IRIS and paradoxical IRIS.Patients with IRIS have clinical features that vary widely. The presentations are strongly dependent on the type of preexisting opportunistic infection. For example, about 75% of patients with a mycobacterial or cryptococcal-related infection will develop a fever. In contrast, fever is rarely seen in cytomegalovirus (CMV) infections.Risk & Prevention.Researchers have found that lower CD4 cell counts or high HIV RNA levels at the time of anti-retroviral treatment initiation increase the risk of developing IRIS. One way to prevent IRIS development is to treat opportunistic infections prior to starting ART. Although this reduces the risk of IRIS development, it does not guarantee it.Treatment.In “unmasking IRIS,” patients can be treated with antibiotics, antivirals, or antifungals against the underlying infectious organism. In severe cases, steroids can also be used to suppress inflammation until the infection has been eradicated. Unfortunately, there is no treatment for paradoxical IRIS. Most patients who experience “paradoxical IRIS” reactions will get better spontaneously without additional therapy.Incidence of IRIS.The overall incidence of IRIS is unknown; however, studies have shown that anywhere from 25 to 30% of HIV patients who start antiretroviral treatment develop IRIS in the first six months. You may ask, which preexisting infections can lead to patients developing IRIS?Pathogens associated with IRIS.Different pathogens have been associated with the development of IRIS. The leading pathogens include:Mycobacterium tuberculosisMycobacterium avium complexCytomegalovirusCryptococcus neoformansPneumocystis jiroveciiHerpes simplex virusHepatitis B virusHuman herpes virus 8 (associated with Kaposi sarcoma)Non-HIV etiologies.IRIS can also be seen in other immunocompromised conditions, such as:Solid organ transplant recipients Postpartum period – 3 to 6 weeks after giving birthNeutropenic patients – with an absolute neutrophil count of less than 500Patients on Tumor Necrosis Factor Antagonists (TNF antagonists)- are used to treat chronic conditions such as ulcerative colitis, Crohn's disease, or sarcoidosis.In summary, Immune Reconstitution Inflammatory Syndrome (IRIS) is a hyper-inflammatory state seen after initiating ART in HIV patients whose improved immune system responds to previously acquired opportunistic infection, whether treated or not.The treatment is directed to the unmasked specific opportunistic infection or support therapy if no active infection is found.____________________________Conclusion: Now we conclude episode number 121, “Immune Reconstitution Inflammatory Syndrome (IRIS).” This syndrome presents in about 30% of HIV patients when they start ART. A stronger immune system means a stronger immune reaction. So, keep in mind this diagnosis when your HIV patients get sicker when they are supposed to get better after starting ART. This week we thank Hector Arreaza, Abeda Farhati, and Katherine Schlaerth. Audio edition by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________Links:“CD4 Lymphocyte Count: MedlinePlus Medical Test.” Medlineplus.gov, accessed on November 4, 2022.https://medlineplus.gov/lab-tests/cd4-lymphocyte-count/#:~:text=A%20CD4%20count%20is%20mostly,have%20trouble%20fighting%20off%20infections.Sun HY, Singh N. Immune reconstitution inflammatory syndrome in non-HIV immunocompromised patients. Curr Opin Infect Dis. 2009 Aug;22(4):394-402. doi: 10.1097/QCO.0b013e32832d7aff. PMID: 19483618. https://pubmed.ncbi.nlm.nih.gov/19483618/Thapa, Sushma, and Utsav Shrestha. “Immune Reconstitution Inflammatory Syndrome.” PubMed, StatPearls Publishing, 2022, www.ncbi.nlm.nih.gov/books/NBK567803/.Wolfe, Cameron. Immune reconstitution inflammatory syndrome, UpToDate. ww.uptodate.com, https://www.uptodate.com/contents/immune-reconstitution-inflammatory-syndrome. Accessed November 14, 2022.Royalty-free music used for this episode: “Keeping Watch,” New Age Landscapes. Downloaded on October 13, 2022, from https://www.videvo.net/royalty-free-music-albums/new-age-landscapes/.
Whether we realize it or not, most of us have experienced some level of trauma over the past few years as we learned to navigate the fallout of COVID-19. As a result, we are changed people (and artists)—but what have we learned? How do we begin to process the impact of the pandemic? And where do we go from here? By now, you've probably heard us mention smARTtalks, a series of intimate learning sessions covering relevant topics for artists and creatives working in the 21st century. On September 24, 2022, Crewest Studio—NOT REAL ART's parent company—produced its first smARTalks event, held at Helms Bakery District in Culver City. In today's podcast episode, we look back on an especially important discussion held during the inaugural event: “Who Are We Now? A Discussion About COVID, Trauma + Creativity. How Did The Pandemic Hurt or Help Us and Our Creativity?”Moderated by your intrepid host, Scott “Sourdough” Power, alongside trauma experts Dr. Kim Cookson and Eric Weiss, this discussion centers on wellness in arts. “Whether we're walking around traumatized—some people are, some people are not—but everyone is working under a new level of stress,” says Dr. Cookson. “They're having to negotiate a new reality.” Tune into today's episode to catch some much-need discourse on the intersection of trauma and creativity, and how you can use art-making as a form of self-care. In Today's Episode:Dr. Kim Cookson and Eric Weiss discuss…The inherent trauma that comes with navigating COVID-19How artists were affected by lockdowns and isolationHow trauma can influence and impact creativityArt as therapy: how artists can use their creativity for self-careBudget-friendly ways to regulate and manage traumaHelpful therapeutic methods such as somatic therapyHow to promote activities that bring you joyTips for finding your “escape hatch” and focusing on the positiveThe silver linings in and around post-traumatic growthFor more info, please visit: https://notrealart.com/trauma-creativity
Film Roundtable is thrilled to be joined this week by Elizabeth Woodward and Sean Glass, Producer and Executive Producer of the newly released (self distributed!)You Resemble Me, and Kyle Greenberg, Head of Marketing and Distribution for Utopia. You Resemble Me, the debut feature by filmmaker Dina Amer, tells the story of Hasna Ait Boulahcen, a women who was falsely accused of being Europe's first female suicide bomber.In this candid conversation moderated by Kyle, Elizabeth and Sean discuss self distributing You Resemble Me, and how that has impacted their perception of the contemporary landscape of film and exhibition. You Resemble Me is open now (November 18) nationwide on 80 screens, after already being extended at New York's Angelika and LA's Laemmle Noho, and receiving the highest per screen average in its opening weekend.Check out this conversation wherever you listen to podcasts and also available to watch on our Youtube Channel.
In this talk, Capitalism as a Moral Ideal: Why the Left and Right are Wrong about Rights, Yaron Brook takes on the issues of healthcare, rights, government involvement, freedom, morality and prosperity. Moderated by Andrew Medworth, Chairman of the Ayn Rand Forum. Presented on January 19, 2010. Hosted by the Ayn Rand Forum in London, UK. For more information on the Ayn Rand Forum, see https://www.youtube.com/user/AynRandForumJoin this channel to get access to perks:https://www.youtube.com/channel/UCabMx-URCjr2toe9wOE3Y-Q/joinLike what you hear? Like, share, and subscribe to stay updated on new videos and help promote the Yaron Brook Show: https://bit.ly/3ztPxTxBecome a sponsor to get exclusive access and help create more videos like this: https://yaronbrookshow.com/support-members/support-the-show/Or make a one-time donation: https://bit.ly/2RZOyJJContinue the discussion by following Yaron on Twitter (https://bit.ly/3iMGl6z) and Facebook (https://bit.ly/3vvWDDC )Want to learn more about Ayn Rand and Objectivism? Visit the Ayn Rand Institute: https://bit.ly/35qoEC3