Study of the causes and effects of disease or injury; the way a given disease or injury presents itself.
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Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Synovial Sarcoma from our Pathology at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Dr. Bobbi S. Pritt joins Tick Boot Camp Podcast for a scientific deep dive into Lyme disease diagnostics, co-infections, and emerging tick-borne pathogens. Dr. Pritt is Professor and Chair of Laboratory Medicine and Pathology at Mayo Clinic and Director of the Clinical Parasitology Laboratory in Rochester, Minnesota. An internationally recognized expert in vector-borne diseases, she is globally known for discovering new tick-borne pathogens—including Borrelia mayonii and Ehrlichia muris eauclairensis—and for advancing cutting-edge molecular and metagenomic diagnostic testing used nationwide. This episode offers essential clarity for anyone navigating Lyme disease, unexplained symptoms, or confusing test results. Dr. Pritt explains why standard tests often miss early Lyme, how PCR and molecular tools can detect active infection, and what metagenomic sequencing may offer for more accurate and comprehensive diagnostics in the future. Episode Summary Dr. Pritt breaks down how Lyme and other tick-borne diseases are detected through antibody testing, PCR, tissue analysis, and cutting-edge molecular methods. She explains how her lab discovered multiple new pathogens in the upper Midwest, the role of tick species in disease transmission, and why co-infections complicate diagnosis. This conversation also explores geographic spread, climate change, tick behavior, and the strengths and limitations of today's test algorithms. Key Topics • Discovery of Borrelia mayonii as a second cause of Lyme disease in the U.S. • Identification and characterization of Ehrlichia muris eauclairensis • Geographic hotspots and why the upper Midwest produces unique pathogens • Tick species differences: blacklegged vs. lone star ticks and their hunting strategies • Co-feeding in ticks and its role in pathogen evolution • Why early Lyme tests often return false-negative results • The science behind false positives and cross-reactivity • PCR advantages and limitations for detecting Borrelia • When skin biopsies can outperform blood tests • Differentiating Lyme, B. miyamotoi, Anaplasma, Babesia, and Powassan virus • When clinicians should order a full tick-borne disease panel • How climate and ecological changes drive new tick-borne threats • The promise of metagenomics and immune-signature diagnostics What You'll Learn • Why current Lyme testing algorithms struggle in early infection • How new tick-borne pathogens are discovered and validated • Why lone star ticks are more aggressive and changing regional risk • When and why molecular testing is more effective • What symptoms point to co-infections needing additional testing • Why doxycycline is not effective for certain pathogens like Babesia • How metagenomic sequencing could identify every pathogen in a single sample • Where diagnostic innovation is heading and what patients can expect
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Foundations, where we review foundational knowledge for frontline MSK providers such as junior orthopaedic residents, ER physicians, and primary care providers. This episode will cover the topic of Osteoid Osteoma from our Pathology at Orthobullets.com.Follow Orthobullets on Social Media:FacebookInstagram TwitterLinkedInYouTube
Dr. Kevin Ko on Biomarkers, Oral Dysplasia, and the Limits of H&E DiagnosisChristine interviews Dr. Kevin Ko (DMD, MD), a pathologist at the BC Cancer Agency with training in oral and maxillofacial pathology, anatomic pathology, and dermatopathology. They discuss his ASDP 2025 lecture on using p53 in oral dysplasia as a potential new approach and the broader problem of diagnostic discordance and over-diagnosis when relying on H&E alone. Dr. Ko shares examples from practice, including recognizing oral porokeratosis (previously followed as dysplasia for years) and a chemotherapy-related lip lesion initially suspected to be severe dysplasia but supported by wild-type biomarker results and clinical history, resolving after stopping chemotherapy drugs. He emphasizes the need for reproducible biomarkers and possibly molecular-based classification to improve consistency and patient outcomes, while also describing the pressure to be near-perfect in pathology, the risk of burnout, and efforts to build sustainable systems (QA sessions, colleague consultation, protected time). The conversation closes with his approach to presentations as storytelling, interest in prospective multi-center research, and a final message about balancing perfectionism with rest while remaining open-minded to new diagnostic methods to improve patient care.00:00 Welcome & Meet Dr. Kevin Ko (DMD/MD, Dermpath at BC Cancer)01:00 The Controversial Idea: Using p53 Biomarkers in Oral Dysplasia01:18 Oral vs Skin Pathology: Discovering Porokeratosis in the Mouth02:07 Diagnostic Error & Overdiagnosis: Why Reproducible Biomarkers Matter05:19 Case Study: “Severe Dysplasia” vs Toxic Erythema of Chemotherapy —Context Changes Everything06:36 The Perfectionism Trap in Pathology (and Why 95% Isn't Good Enough)08:04 Burnout, QA Systems, and Building Sustainable Workflows09:14 Work–Life Balance, Kids, and Choosing Priorities (Family vs Research)11:14 How to Build a Great Talk: Storytelling, Cases, and Future Studies11:38 Final Takeaways: Balance, Open-Mindedness, and Better Diagnostics
The ABMP Podcast | Speaking With the Massage & Bodywork Profession
A school administrator and massage therapist wants guidance on how to respond to a student who is reluctant to work with clinic clients who report a history of herpes. Is this a significant risk for massage therapists? The reality is that anyone with a history of herpes simplex can shed the virus intermittently, even without visible symptoms. However, the risk to massage therapists who follow proper hygiene and self-care protocols is extremely low. In that sense, herpes falls into the same category as other infections that may be transmitted through direct contact but are effectively managed with consistent hygienic practices. The key issue is not the client's infection status; it is the therapist's adherence to appropriate hygiene protocols. Resources: Ang, J.Y. et al. (2012) "A Randomized Placebo-Controlled Trial of Massage Therapy on the Immune System of Preterm Infants," Pediatrics, 130(6), pp. e1549–e1558. Available at: https://doi.org/10.1542/peds.2012-0196. Contributors, W.E. (no date) Genital Herpes Treatment Options, WebMD. Available at: https://www.webmd.com/genital-herpes/genital-herpes-treatment-options (Accessed: March 7, 2025). Globally, an estimated two-thirds of the population under 50 are infected with herpes simplex virus type 1 (no date). Available at: https://www.who.int/news/item/28-10-2015-globally-an-estimated-two-thirds-of-the-population-under-50-are-infected-with-herpes-simplex-virus-type-1 (Accessed: March 6, 2025). Herpes simplex Information | Mount Sinai - New York (no date) Mount Sinai Health System. Available at: https://www.mountsinai.org/health-library/report/herpes-simplex (Accessed: March 6, 2025). Herpes simplex virus (no date). Available at: https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus (Accessed: March 6, 2025). How many people have herpes? Myths, facts, and statistics (2020). Available at: https://www.medicalnewstoday.com/articles/how-many-people-have-herpes (Accessed: March 6, 2025). Kaneko, H. et al. (2008) "Evaluation of mixed infection cases with both herpes simplex virus types 1 and 2," Journal of Medical Virology, 80(5), pp. 883–887. Available at: https://doi.org/10.1002/jmv.21154. Line is blurring between human herpes simplex viruses (no date) UW Medicine | Newsroom. Available at: https://newsroom.uw.edu/news-releases/line-blurs-between-human-herpes-simplex-viruses (Accessed: March 6, 2025). Products - Data Briefs - Number 304 - February 2018 (2019). Available at: https://www.cdc.gov/nchs/products/databriefs/db304.htm (Accessed: March 6, 2025). Ramchandani, M. et al. (2016) "Herpes Simplex Virus Type 1 Shedding in Tears, and Nasal and Oral Mucosa of Healthy Adults," Sexually transmitted diseases, 43(12), pp. 756–760. Available at: https://doi.org/10.1097/OLQ.0000000000000522. Rapaport, M.H., Schettler, P. and Bresee, C. (2012) "A Preliminary Study of the Effects of Repeated Massage on Hypothalamic–Pituitary–Adrenal and Immune Function in Healthy Individuals: A Study of Mechanisms of Action and Dosage," Journal of Alternative and Complementary Medicine, 18(8), pp. 789–797. Available at: https://doi.org/10.1089/acm.2011.0071. Usatine, R.P. and Tinitigan, R. (2010) "Nongenital Herpes Simplex Virus," American Family Physician, 82(9), pp. 1075–1082. (2025) "Herpes Simplex Treatment & Management: Approach Considerations, Medical Care, Consultations." Available at: https://emedicine.medscape.com/article/218580-treatment (Accessed: March 7, 2025). Host Bio: Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com. Sponsors: Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function. Website: anatomytrains.com Email: info@anatomytrains.com Facebook: facebook.com/AnatomyTrains Instagram: www.instagram.com/anatomytrainsofficial YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA Precision Neuromuscular Therapy seminars (www.pnmt.org) have been teaching high-quality seminars for more than 20 years. Doug Nelson and the PNMT teaching staff help you to practice with the confidence and creativity that comes from deep understanding, rather than the adherence to one treatment approach or technique. Find our seminar schedule at pnmt.org/seminar-schedule with over 60 weekends of seminars across the country. Or meet us online in the PNMT Portal, our online gateway with access to over 500 videos, 37 NCBTMB CEs, our Discovery Series webinars, one-on-one mentoring, and much, much more! All for the low yearly cost of $167.50. Learn more at pnmt.thinkific.com/courses/pnmtportal! Follow us on social media: @precisionnmt on Instagram or at Precision Neuromuscular Therapy Seminars on Facebook. Upledger CranioSacral Therapy addresses deep restrictions, supports neurological and fascial systems, and enhances whole-body function—by working with the body's natural healing processes. For over forty years, Upledger Institute International has led the field of CranioSacral Therapy—setting the global standard for education and clinical application. With trained therapists in more than 120 countries, CST continues to evolve through ongoing clinical experience and alignment with current scientific understanding. CST integrates seamlessly into any manual therapy practice and supports common to complex and chronic conditions—orthopedic, neurological, pediatric, geriatric, and beyond. Learn from our International Teaching Team—experienced clinicians who help you develop your skills, expand your clinical reasoning, and achieve greater clinical outcomes. Begin your training for as little as one hundred dollars a month. Find a class near you at upledger.com/courses or call 800-233-5880, extension 2—and begin your CranioSacral Therapy journey with the leaders who continue to shape the profession. Website: upledger.com/courses Email: upledger@upledger.com Phone: 800-233-5880 Ext 2 Facebook: https://www.facebook.com/upledger.institute Instagram: https://www.instagram.com/upledger_institute_intl/ YouTube: https://www.youtube.com/channel/UCSIFELbP6Jsp55cb9puZigQ Somatic Mindfulness helps massage therapists prevent physical and emotional burnout by integrating somatic principles into bodywork. Created by Fernando Rojas, LMT, PhD, Massage Hall of Famer, Master Somatic Therapist, Educator, and author of Embodied Presence & Attuned Touch, it teaches self-care as a professional skill so that the therapist's own wellbeing becomes the method for creating the conditions for healing and clarity of purpose. Through continuing education workshops, somatic touch training, and mindful self-study, Fernando helps therapists work sustainably, communicate clearly, and rediscover meaning in their practice. https://somaticmindfulness.co/ https://www.facebook.com/somatic.mindfulness https://www.instagram.com/somatic.mindfulness/
Send a textSometimes a paper comes out that's so practical and relevant to what we do in digital pathology that I know we have to talk about it.In this episode, I dive into “A Guide for the Deployment, Validation and Accreditation of Clinical Digital Pathology Tools” from Geneva University Hospital (HUG) — one of the most useful, real-world frameworks I've seen for bringing digital pathology tools safely into clinical practice.If you've ever built an AI model and wondered, “Now what?”, this episode is for you. Because building the model is often the easy part — deployment is where things get complex.This guide breaks the process into four practical phases every lab can follow:1️⃣ Pre-Development – Define your clinical need, project scope, and validation plan before writing a single line of code. 2️⃣ Development – Build and integrate the algorithm in a production-ready environment. 3️⃣ Validation & Hardening – Turn your research code into a reliable, secure, and compliant clinical tool. 4️⃣ Production & Monitoring – Keep the tool validated and performing consistently over time.We also discuss what makes qualification, validation, and accreditation different — and why that order really matters. You'll hear about the multidisciplinary team behind these deployments, especially the deployment engineer (DE) — the technical linchpin who turns AI research into clinical reality.I share the story of HUG's H. pylori detection tool, which cut diagnostic time by 26% while maintaining a 0% false negative rate. The team's secret? Careful planning, quality control, and continuous user feedback — not just great code.Other highlights include:Why integration often takes longer than building the AI model itselfHow to avoid invalidating your validation dataWhat continuous performance monitoring looks like in real labsAnd why every lab still needs to do local validation, even with proven toolsIf you're working on digital or computational pathology tools — or just want to understand how AI safely moves from research to routine diagnostics — this episode will give you a roadmap grounded in real experience.
Send a textWhat if one of the biggest sources of diagnostic variability in prostate cancer isn't the pathologist—but the stain we've trusted for decades?In this episode, I speak with Professor Ingied Carlbom, founder of CADESS.AI, about a different way to approach prostate cancer grading—by rethinking staining, segmentation, and AI decision support from the ground up. We explore why 30–40% interobserver variability persists in Gleason grading and how optimized stains combined with explainable AI can significantly reduce that uncertainty.Ingred shares her journey from applied mathematics and computer science into pathology, the skepticism she faced in 2008, and why CADESS.AI chose not to “optimize H&E,” but instead developed a Picrosirius red + hematoxylin stain designed specifically for computational pathology. We discuss how grading at the gland and cellular level improves reproducibility, why explainability matters for trust, and what it really takes to build both stain and software as a single diagnostic workflow.This conversation challenges long-held assumptions—and asks whether improving data quality should come before building smarter algorithms.Highlights:[00:00–01:08] The problem: 30–40% disagreement in prostate cancer grading[01:08–03:03] Ingrid's path from applied math to digital pathology[03:03–04:58] Early skepticism toward AI in pathology and fear of replacement[04:58–08:56] Why H&E limits segmentation—and how a new stain changes that[10:55–15:09] Clinical testing: non-inferiority, AI assistance, and NCCN risk stratification[19:47–22:59] Explainable UI: color-coded glands and pathologist override[26:16–27:29] Why grading glands (not whole slides) reduces variability[38:09–41:47] Regulatory challenges of combined stain + AI devices[45:52–48:55] The future of optimized stains in routine pathologyResources from This EpisodeCADESS.AI – Prostate cancer decision support systemNCCN prostate cancer risk stratification guidelinesSupport the showGet the "Digital Pathology 101" FREE E-book and join us!
Hyland Brings Enterprise Content Management to Pathology with TribunDigital pathology adoption is picking up speed, but many organizations are discovering that scanners and AI alone do not solve the hard problems. The real challenge is the lack of standards that holds back efforts to scale and optimize. In this interview, Michael Campbell, Chief Product Officer at Hyland, breaks down why enterprise content management is becoming essential for digital pathology. He explains Hyland's partnership with Tribun Health, how responsibilities are split between digitization, analysis, and backend imaging governance, and what health IT leaders should be thinking about as pathology moves beyond pilot programs. The conversation also touches on Hyland's broader product roadmap, including how agentic AI fits into enterprise workflows and why transparency and auditability matter for adoption.Where do you see the biggest bottleneck in digital pathology today? Is it technology, standards, or operational governance? Share your perspective in the comments.
Send a textIs AI in pathology actually improving diagnosis — or just adding complexity?In DigiPath Digest #37, we reviewed four recent publications covering AI-based biomarker quantification in glioblastoma, real-world digital workflow integration in prostate cancer, multimodal AI combining histopathology and genomics, and patient perspectives on AI in cancer diagnostics.This episode connects technical performance with something equally important: trust.Episode Highlights[00:02] Community & updates Digital Pathology 101 free PDF, upcoming patient-focused book, and global attendance.[04:07] AI-based image analysis in glioblastoma AI showed strong consistency with pathologists when quantifying Ki-67, P53, and PHH3. Significant biological correlations (Ki-67 ↔ PHH3, PHH3 ↔ P53) were detected by AI — not by manual assessment. Takeaway: computational quantification improves precision.[09:28] Real-world digital workflow + AI in prostate cancer (France) AI-pathologist concordance: • 93.2% (high probability cancer detection) • 99.0% (low probability slides) Gleason concordance: 76.6% 10% failure rate due to pre-analytical artifacts. Takeaway: infrastructure and sample quality still matter.[15:58] Multimodal AI (MARBIX framework) Combines whole slide images + immunogenomic data in a shared latent space using binary “monograms.” Performance in lung cancer: 85–89% vs 69–76% unimodal models. Takeaway: integrated data improves case retrieval and similarity reasoning.[22:13] AI-powered paper summary subscription introduced Structured summaries for busy professionals who want more than abstracts.[26:17] Patient roundtable on AI in pathology (Belgium) Patients expect: • Better accuracy • Faster turnaround • Stronger collaborationTrust is high when: • Algorithms use diverse datasets • Pathologists retain final responsibilityClinical validity mattered more than full algorithm transparency. Privacy concerns focused more on insurer misuse than cloud transfer.Key TakeawaysAI improves biomarker precision in glioblastoma.Digital pathology implementation works — but pre-analytics can limit AI performance.Multimodal AI represents the next meaningful step in precision diagnostics.Patients are not afraid of AI — they want validation, oversight, and governance.Human–AI collaboration remains central.If you're working in digital pathology, computational pathology, or precision oncology, this episode connects evidence, implementation, and patient perspective.Support the showGet the "Digital Pathology 101" FREE E-book and join us!
Hatred toward those who wounded you does not function as evidence of moral failure, spiritual immaturity, or psychological pathology; it functions as unprocessed attachment energy trapped in a nervous system that never received completion. The question therefore does not hinge on whether you may hate the person who hurt you, but whether hatred serves as an adaptive transitional response or calcifies into identity. From a neurobiological perspective, resentment reflects an activated threat circuit seeking resolution; from an attachment lens, it signals a ruptured bond demanding coherence; from an anthropological frame, it preserves group survival memory; from a spiritual dimension, it exposes the ego's attempt to metabolize betrayal without dissolving itself. Safe space, then, does not exist to justify hatred—it exists to convert raw affect into integrated meaning. The most efficient release of anger does not involve suppression, performance forgiveness, or retaliatory fantasy; it requires conscious exposure, somatic discharge, narrative restructuring, and identity reorganization. In other words, hatred may begin as protection—but if it remains unexamined, it becomes self-incarceration. The real question hides underneath the obvious one: Do you want justice, or do you want freedom?
Over the past several decades, neuroendocrine cancer diagnoses have increased significantly—raising an important question: Are these cancers becoming more common, or are we simply getting better at finding them? In this episode of NETWise, leading clinicians, researchers, and a patient share what the data—and real-world experience—reveal about this trend.Drawing on insights from global experts and patient perspectives, this conversation explores how advances in imaging, pathology, and research are reshaping what we know about neuroendocrine cancer—and why earlier recognition is changing the landscape of care.In this episode, you'll hear about:Why diagnoses have risen dramatically in recent decades—and why improved detection explains much of the increaseHow modern imaging, screening, and updated classification systems are helping doctors identify tumors earlier and more accuratelyThe environmental, biological, and social factors researchers are still working to understandWhy many tumors are now discovered incidentally, before symptoms appearHow earlier detection creates both new opportunities—and new questions—about screening and treatment decisionsA patient's personal story of diagnosis and how awareness can lead to earlier answers and better outcomesAs understanding grows, so does the ability to diagnose neuroendocrine cancer with greater precision—and to treat it more effectively. This episode brings clarity to what's behind the rising numbers and what that progress means for patients and families today.Whether you're a patient, caregiver, clinician, or advocate, this episode offers clear, accessible insights into the breakthroughs driving research forward. Please like, share, and subscribe. Your engagement helps us reach more patients and caregivers seeking reliable neuroendocrine cancer information—and supports NETRF's mission to expand research, awareness, and hope across the NET community. NET specialists included in this episodeUse our episode infographics to get a visual picture of some of the things we have discussed. Ulrich-Frank Pape, MDGastroenterologist, Asklepios Klinik St. Georg, Hamburg, Germany Arvind Dasari, MDGastrointestinal Medical Oncologist, MD Anderson Cancer Center Neil Renwick, MD, PhD, FRCPCAssistant Professor, Department of Pathology & Molecular Medicine, Queen's University(SEAMO New Clinician-Scientist Program) Nancy Joseph, MD, PhDProfessor of Surgical Pathology, University of California, San Francisco (UCSF) A special thank you to Jessica Ochoa for sharing her neuroendocrine cancer journey. Download a transcript of this episode. The post Episode 52: Why Is Neuroendocrine Cancer on the Rise? appeared first on NETRF.
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In this Mind Moments episode, Jeff Chamberlain, PhD, joins the podcast during Duchenne Muscular Dystrophy Awareness Week to provide clinical and translational perspective on the evolving landscape of DMD biology and therapy. Chamberlain, professor at the University of Washington School of Medicine and Director of the Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center in Seattle, reflects on aspects of Duchenne pathophysiology that may still be underappreciated, including evidence that disease processes begin earlier than once recognized and the growing importance of immunologic factors in shaping progression and therapeutic response. The conversation also explores how neuromuscular specialists should approach treatment timing and combination strategies as gene-targeted therapies expand, the evolving interpretation and limitations of biomarkers such as creatine kinase and dystrophin expression, and what emerging gene therapy platforms may signal for care heading into 2026 and beyond.Looking for more Neuromuscular discussion? Check out the NeurologyLive® Neuromuscular clinical focus page.Episode Breakdown: 1:15 – Underrecognized aspects of DMD pathophysiology, including early onset and immunologic drivers 4:50 – Treatment timing, sequencing, and the rationale for combination strategies 8:00 – Neurology News Minute 10:30 – Clinical trial and real-world implications of dystrophin and CK as biomarkers 16:20 – Anticipated gene therapy innovation and safety considerations heading into 2026 The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Regenxbio's MPS II Gene Therapy RGX-121 Hit With CRL FDA Accepts New Drug Application for Orexin Agonist Oveporexton in Narcolepsy Type 1, Grants Priority Review FDA Expands Indication for Pitolisant to Treat Cataplexy in Pediatric Narcolepsy Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
Send a textWhat actually needs to be in place before digital pathology can replace the microscope?In this episode of DigiPath Digest, I walk through the 2026 Polish Society of Pathologists guidelines and translate them into practical steps for real pathology labs. This isn't theory. It's about hardware fidelity, data integrity, validation, and AI integration — and what each of these actually requires in daily workflow.We talk about scanner resolution standards (≤0.26 μm per pixel), 4K monitor calibration, visually lossless compression (20:1), scalable storage, pathologist-driven validation, and what “non-inferiority” truly means.Digital pathology is not just a change of medium. It's an operational shift.Episode Highlights[00:02] Community & growth 1,600+ new newsletter subscribers, 10,000+ Facebook members, and free Digital Pathology 101 book access.[07:20] The 4 pillars of adoption Hardware fidelity · Data integrity · Clinical validation · Future integration.[08:30] Hardware requirements 40x equivalent scanning (≤0.26 μm/px), 4K monitors, >300 cd/m² luminance, 10-bit color depth.[12:00] Workflow & throughput 200–300 slides/day per scanner, automated focus control, urgent case prioritization.[17:25] Storage & archiving ~1 GB per slide. Active archive (6–24 months). Long-term retention (10–20 years). GDPR compliance & TLS encryption.[23:09] Validation philosophy Pathologist-centered validation. Two phases: • Familiarization (~20 retrospective cases) • Dual review with discrepancy tracking Goal: digital must be non-inferior to glass.[29:03] AI in digital pathology AI supports quantification (Ki-67, HER2, ER/PR, PD-L1), tumor detection, and future multimodal predictions — but pathologists remain central.[33:26] Intraoperative telepathology
Recorded live at a SAND Community Gathering (Feb 2026) Dr. Samah Jabr, a Palestinian psychiatrist and author of Radiance in Pain and Resilience, joins Dr. Mays Imad (with questions from the audience chat) for a conversation about what it means to stay human when the structures meant to protect people are the ones doing the harm. Drawing on decades of clinical work inside the occupation, Dr. Jabr moves past the “sanitized” versions of trauma to speak directly to the heart of colonial harm in Palestine. Central to this dialogue is an exploration of the deep ontological differences between Western psychiatric models and Palestinian lived experience. While Western frameworks often pathologize the individual through the lens of PTSD, Dr. Jabr introduces the concept of iptila—viewing tribulations through a framework of agency, faith, and collective endurance. She challenges the frequent romanticization of sumud (steadfastness), reframing it not as a poetic trope, but as a grueling relational practice and an ethical refusal to disappear when everything conspires toward Palestinian erasure. In a reality where the harm never ends, memory becomes a battlefield, grief a form of testimony, bearing witness an active refusal to normalize the unacceptable, and storytelling a vital survival infrastructure against the assassination of memory. Topics 00:00 Welcome & Why We Need a New Framework for Trauma and Justice 02:15 “If I Must Die”: Carrying Memory, Refusing Normalization 03:13 Introducing Dr. Samah Jabr's Work: Pain, Power, and a Counter-Narrative 07:55 A Childhood Lesson in Naming: Robinson Crusoe and Colonial Language 10:10 Clinic Stories: When Political Reality Shapes Symptoms 14:14 Beyond Western Psychiatry: Language, Resilience, and Context as the ‘Pathology' 17:19 The ‘Fear of Dogs' Case: History, Colonial Violence, and Clinical Meaning 20:40 When Systems Collapse: Gaza's Crushed Mental-Health Response & Organic Community Care 25:04 Collective Healing & the Kite Intervention: Building Agency and Connection 29:31 From Mobilization to Organization: Global Solidarity and Liberation 34:31 How to Keep Working: Hope, Spirituality, and Protecting Health Workers 41:58 Meaning-Making in Crisis: The Palm Tree Story and Spiritual Grounding 45:22 Spirituality as Resilience: Listening for What Helps Each Person 47:13 Scaling Mental Health Support in Palestine: Training Community Helpers 49:00 Creating “Healing Spaces”: Group Support for Journalists, Youth & Displaced Women 53:22 Reporting Gaza From Afar: Citizen Journalism, Narrative Control & Ethical Witnessing 59:44 How to Support Palestine Sustainably: Remote Mental Health, Publishing & Advocacy 01:05:37 Colonialism, Patriarchy & Horizontal Violence: When Trauma Damages the Social Fabric 01:10:03 Meaning-Making Under Protracted Trauma: Tila, Agency & Shattered Belief Systems 01:15:16 Diaspora Palestinians: From Helping Family to Leading Global Political Solidarity 01:21:55 Closing Charge: Being Human After Mass Violence + Upcoming Webinars & Films Resources Dr. Samah Jabr's book Art by Fernando Martí and Jess X. Snow, inspired by Huda Suboh's quote: “In the heart of Gaza, where the echoes of war reverberate through the streets… each day, glimmers of hope that dance across the sky—kites.” — Rafah, 2024 Support this conversation by donating to Sumud Network for Mental Health and Healing for Gaza Where Olive Trees Weep (Film by SAND on Palestine (2024) with more Resources and a course on Palestine)
Dr. Raymond Barnhill on Diagnostic Drift, Uncertainty, and the MPATH-Dx V2.0 Approach to Melanocytic LesionsIn this episode of The Girl Doc Survival Guide, Christine interviews Dr. Raymond Barnhill, a world-recognized dermatopathology expert known for work on diagnostically challenging melanocytic lesions, melanoma pathology references, and contributions to WHO skin tumor classification and AJCC melanoma staging. Dr. Barnhill shares career anecdotes and key communities at Yale and in Boston, collaborations with numerous melanoma leaders, and the founding of the North American Melanoma Pathology Study Group and the International Melanoma Pathology Study Group, as well as participation in the NIH-funded MPATH Study Group. The discussion focuses on overdiagnosis, underdiagnosis, and diagnostic discordance in melanocytic lesions, including evidence of diagnostic drift toward calling more lesions melanoma over time and the overlap between melanoma criteria and atypical/dysplastic nevi. He describes MPATH research, explains the revised MPATH-Dx V2.0 schema, explicitly recognizing uncertainty along a continuum rather than a strict benign/malignant threshold. He emphasizes practical diagnostic approaches including measuring lesion size (noting a 4 mm threshold associated with conventional dysplastic nevi and increasing concern at larger sizes), focusing on key architectural features (junctional nest variation/disarray and lentiginous proliferation), using nuclear size relative to keratinocyte nuclei (including a 1.5× threshold and counting atypical cells per high-power field) while accounting for site-specific pitfalls such as scalp nevi. The conversation also covers “gestalt” versus systematic review, the importance of due diligence using full clinical and morphologic information before ancillary testing, and cautions against overreliance on immunohistochemistry or molecular tests. Dr. Barnhill closes with career advice ends with a message that setbacks can be opportunities for growth.00:00 Welcome + Meet Dr. Raymond Barnhill (Dermatopathology Legend)01:51 Career Origins & Melanoma Pathology Mentors (Yale → Boston)03:59 Building Melanoma Pathology Study Groups (North American & International)05:57 Overdiagnosis, Diagnostic Drift & Why Discordance Happens09:43 Inside the MPATH Study: Measuring Interobserver & Intraobserver Agreement11:39 MPATH-Dx V2.0 Explained: Standardized Classes & Treatment Guidance13:59 Redefining “Low-Risk” Melanoma: Stringent pT1a Criteria + Embracing Uncertainty18:47 Practical Grading Tips: Lesion Size, Architecture & Nuclear Atypia Thresholds22:42 Gestalt vs Due Diligence: Avoiding Traps + Using IHC/Molecular Wisely (PRAME)28:39 Career Advice: Passion, Mentors, Community + Final Reflections
Have you longed to integrate your Christian faith into your patient care—on the mission field abroad, in your work in the US, and during your training? Are you not sure how to do this in a caring, ethical, sensitive, and relevant manner? This “working” session will explore the ethical basis for spiritual care and provide you with professional, timely, and proven practical methods to care for the whole person in the clinical setting. https://www.dropbox.com/scl/fi/qpah9kh1lttg6cm1jjop9/Bob-Mason-Ethics-of-Spiritual-Care-revised.pptx?rlkey=0emve2ja8282nv8xc4uinq1hg&st=9033htwx&dl=0
This episode features Chris Breitigan reading 3 neurology questions from our online qbank. Dr. Ted O'Connell Ted O'Connell, MD, FAAFP, is the Director of Medical Education for Kaiser Permanente Northern California. He is also an Associate Clinical Professor in the Department of Family and Community Medicine at the UC San Francisco School of Medicine. Ted has authored over 20 medical textbooks, edited 10 additional textbooks, and has written over 900 textbook chapters as well as articles in peer-reviewed medical journals. Ted has been involved in medical education for over two decades, serving as Founding Program Director at the Kaiser Permanente Napa-Solano family medicine residency program for 10 years and the Program Director at the Kaiser Permanente Woodland Hills residency program for 7 years. Ted is Editor-In-Chief of Elsevier's Clinical Key Student, an international medical education platform. Ted is also the award-winning host of several podcasts. Dr. Raj Dasgupta Dr. Raj is a quadruple board-certified physician and associate professor at the University of Southern California. He was a co-host on the TNT series Chasing the Cure with Ann Curry, a regular on the TV Show The Doctors for the past 7 seasons and has a weekly medical segment on ABC news Los Angeles. Our Websites MedPrepToGo Website BookRevision.com Dr. O'Connell's Website Dr. Dasgupta's Website Other Podcasts USMLE Step 1 Questions USMLE Step 1 Ad-Free Bundle Crush Step 1 Step 2 Secrets Beyond the Pearls The Dr. Raj Podcast Beyond the Pearls Premium USMLE Step 3 Review Legal/Credits All information is for entertainment and educational purposes only and is not intended as medical advice. Learn more about your ad choices. Visit megaphone.fm/adchoices
Dr. Gabriel Blass shares a fascinating case of an infant with a rare genetic bone disorder and how homeopathy helped support the child's health. He also used AI to explore potential remedies and even a homeopathic preparation made from a pharmaceutical medicine, which produced impressive results. The episode reveals how curiosity, creativity, and careful listening can open doors in even the most challenging medical cases. Episode Highlights: 03:34 - Tips for using AI responsibly 05:52 - Malignant Osteopetrosis Case in an Infant 09:35 - Different types of Osteopetrosis 11:29 - Purpose of Bone Remodelling 14:10 - Repertorization + Muscle Testing 16:32 - First Prescription: Silica + Hecla Lava and the Once-Weekly Dosing Choice 18:36 - Genetics Confirm Malignant Form 20:09 - Treatment Pivot 23:35 - Third Follow-Up: Strength Gains, Stability, and Early Mobility Improvements 26:02 - Switching From Analysis to Intuition 30:04 - Shortlisting Homeopathic Drug Remedies 32:43 - Testing & Prescribing: Atorvastatin Emerges as the Key Remedy 35:32 - Potency Changes, Hecla Lava/Sulfur Added, Child Thrives 39:27 - DNA Hardware vs Vital Force Software 43:23 - Single-Gene Defects, COV!D/mRNA Speculation About my Guests: Dr. Gabriel Blass is a distinguished homeopathic physician and educator based in Glasgow, Scotland, with decades of experience in both conventional and complementary medicine. He earned a B.Sc. Honours degree in Pathology in 1986 and completed his M.B. Ch.B. with Commendation from the Faculty of Medicine at the University of Glasgow in 1988. Dr. Blass has been actively involved in homeopathic medicine since 1987 and currently practises as a homeopathic doctor in Glasgow. Alongside his clinical work, he is deeply committed to advancing the field of homeopathy through education and professional development. He regularly lectures to doctors, homeopaths, and other health-care professionals, delivers public presentations, and trains students pursuing studies in homeopathy. In addition to his clinical and teaching roles, Dr. Blass contributes to the academic community by translating scientific papers for Homeopathy (formerly The British Homeopathic Journal), helping make research more accessible to practitioners worldwide. He is a Registered Member of the Society of Homeopaths, adhering to its Code of Ethics and high academic and clinical standards. Dedicated to excellence in patient care and professional growth, Dr. Blass maintains an ongoing programme of Continuing Professional Development, reflecting his belief that learning is a lifelong journey. Find out more about Gabriel Website: https://www.homeopathy-glasgow.co.uk/ If you would like to support the Homeopathy Hangout Podcast, please consider making a donation by visiting www.EugenieKruger.com and click the DONATE button at the top of the site. Every donation about $10 will receive a shout-out on a future episode. Join my Homeopathy Hangout Podcast Facebook community here: https://www.facebook.com/groups/HelloHomies Follow me on Instagram https://www.instagram.com/eugeniekrugerhomeopathy/ Here is the link to my free 30-minute Homeopathy@Home online course: https://www.youtube.com/watch?v=vqBUpxO4pZQ&t=438s Upon completion of the course - and if you live in Australia - you can join my Facebook group for free acute advice (you'll need to answer a couple of questions about the course upon request to join): www.facebook.com/groups/eughom
Crystal asks, how does a whole team fail upward so successfully? When you take six years to investigate a simple question, and then the answer is either wrong or "unexplained," naturally the Feds give you a promotion and a raise.
In Pathology of Plenty: Natural Resources in International Law (Bloomsbury 2025), Lys Kulamadayil offers a crucial examination of how international law shapes the exploitation of natural resources in post-colonial States. Kulamadayil reveals how international legal rules can be constitutive, punitive, remedial in creating the paradox of plenty in resource-rich States. The book revisits the making of foundational principles like sovereignty over natural resources and economic self-determination as applied during decolonisation; explores how humanitarian frameworks have justified extraction of public natural resources; and traces the proliferation of international treaties that protect foreign property rights. The book also zooms in on legal paradigms ranging from contract law to anti-corruption, human rights, and criminal law, arguing that these frameworks often work together to create the pathology of plenty. Through this interrogation, the book points to proposals to escape siloed ways of thinking about natural resources and embrace an intersectoral and anti-carceral thinking instead. Lys Kulamadayil is a Swiss National Science Foundation Ambizione Fellow at the Graduate Institute of International and Development Studies in Geneva and the Principal Investigator of the project Law by Colour Code: Locating Race and Racism in International Law. Raghavi Viswanath is a postdoctoral researcher and teaching fellow at SOAS, University of London. Her research, supported by the Leverhulme Trust, examines how pastoralists claim grazing rights under India's Forest Rights Act 2006 and how the everyday processes of staking such claims has been impacted by the authoritarian turn in India. LinkedIn. Email:rv13@soas.ac.uk Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
In Pathology of Plenty: Natural Resources in International Law (Bloomsbury 2025), Lys Kulamadayil offers a crucial examination of how international law shapes the exploitation of natural resources in post-colonial States. Kulamadayil reveals how international legal rules can be constitutive, punitive, remedial in creating the paradox of plenty in resource-rich States. The book revisits the making of foundational principles like sovereignty over natural resources and economic self-determination as applied during decolonisation; explores how humanitarian frameworks have justified extraction of public natural resources; and traces the proliferation of international treaties that protect foreign property rights. The book also zooms in on legal paradigms ranging from contract law to anti-corruption, human rights, and criminal law, arguing that these frameworks often work together to create the pathology of plenty. Through this interrogation, the book points to proposals to escape siloed ways of thinking about natural resources and embrace an intersectoral and anti-carceral thinking instead. Lys Kulamadayil is a Swiss National Science Foundation Ambizione Fellow at the Graduate Institute of International and Development Studies in Geneva and the Principal Investigator of the project Law by Colour Code: Locating Race and Racism in International Law. Raghavi Viswanath is a postdoctoral researcher and teaching fellow at SOAS, University of London. Her research, supported by the Leverhulme Trust, examines how pastoralists claim grazing rights under India's Forest Rights Act 2006 and how the everyday processes of staking such claims has been impacted by the authoritarian turn in India. LinkedIn. Email:rv13@soas.ac.uk Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/world-affairs
In Pathology of Plenty: Natural Resources in International Law (Bloomsbury 2025), Lys Kulamadayil offers a crucial examination of how international law shapes the exploitation of natural resources in post-colonial States. Kulamadayil reveals how international legal rules can be constitutive, punitive, remedial in creating the paradox of plenty in resource-rich States. The book revisits the making of foundational principles like sovereignty over natural resources and economic self-determination as applied during decolonisation; explores how humanitarian frameworks have justified extraction of public natural resources; and traces the proliferation of international treaties that protect foreign property rights. The book also zooms in on legal paradigms ranging from contract law to anti-corruption, human rights, and criminal law, arguing that these frameworks often work together to create the pathology of plenty. Through this interrogation, the book points to proposals to escape siloed ways of thinking about natural resources and embrace an intersectoral and anti-carceral thinking instead. Lys Kulamadayil is a Swiss National Science Foundation Ambizione Fellow at the Graduate Institute of International and Development Studies in Geneva and the Principal Investigator of the project Law by Colour Code: Locating Race and Racism in International Law. Raghavi Viswanath is a postdoctoral researcher and teaching fellow at SOAS, University of London. Her research, supported by the Leverhulme Trust, examines how pastoralists claim grazing rights under India's Forest Rights Act 2006 and how the everyday processes of staking such claims has been impacted by the authoritarian turn in India. LinkedIn. Email:rv13@soas.ac.uk Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/environmental-studies
In Pathology of Plenty: Natural Resources in International Law (Bloomsbury 2025), Lys Kulamadayil offers a crucial examination of how international law shapes the exploitation of natural resources in post-colonial States. Kulamadayil reveals how international legal rules can be constitutive, punitive, remedial in creating the paradox of plenty in resource-rich States. The book revisits the making of foundational principles like sovereignty over natural resources and economic self-determination as applied during decolonisation; explores how humanitarian frameworks have justified extraction of public natural resources; and traces the proliferation of international treaties that protect foreign property rights. The book also zooms in on legal paradigms ranging from contract law to anti-corruption, human rights, and criminal law, arguing that these frameworks often work together to create the pathology of plenty. Through this interrogation, the book points to proposals to escape siloed ways of thinking about natural resources and embrace an intersectoral and anti-carceral thinking instead. Lys Kulamadayil is a Swiss National Science Foundation Ambizione Fellow at the Graduate Institute of International and Development Studies in Geneva and the Principal Investigator of the project Law by Colour Code: Locating Race and Racism in International Law. Raghavi Viswanath is a postdoctoral researcher and teaching fellow at SOAS, University of London. Her research, supported by the Leverhulme Trust, examines how pastoralists claim grazing rights under India's Forest Rights Act 2006 and how the everyday processes of staking such claims has been impacted by the authoritarian turn in India. LinkedIn. Email:rv13@soas.ac.uk Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/law
In Pathology of Plenty: Natural Resources in International Law (Bloomsbury 2025), Lys Kulamadayil offers a crucial examination of how international law shapes the exploitation of natural resources in post-colonial States. Kulamadayil reveals how international legal rules can be constitutive, punitive, remedial in creating the paradox of plenty in resource-rich States. The book revisits the making of foundational principles like sovereignty over natural resources and economic self-determination as applied during decolonisation; explores how humanitarian frameworks have justified extraction of public natural resources; and traces the proliferation of international treaties that protect foreign property rights. The book also zooms in on legal paradigms ranging from contract law to anti-corruption, human rights, and criminal law, arguing that these frameworks often work together to create the pathology of plenty. Through this interrogation, the book points to proposals to escape siloed ways of thinking about natural resources and embrace an intersectoral and anti-carceral thinking instead. Lys Kulamadayil is a Swiss National Science Foundation Ambizione Fellow at the Graduate Institute of International and Development Studies in Geneva and the Principal Investigator of the project Law by Colour Code: Locating Race and Racism in International Law. Raghavi Viswanath is a postdoctoral researcher and teaching fellow at SOAS, University of London. Her research, supported by the Leverhulme Trust, examines how pastoralists claim grazing rights under India's Forest Rights Act 2006 and how the everyday processes of staking such claims has been impacted by the authoritarian turn in India. LinkedIn. Email:rv13@soas.ac.uk Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode of Denatured, Jennifer C. Smith-Parker speaks with Dr. Rob Monroe, Vice President and Chief Scientific Officer of Oncology at Danaher Corporation and Chief Medical Officer at Leica Biosystems, and Jennifer Fakish, Vice President and Franchise Head of Oncology at Danaher Corporation. We'll be discussing how antibody drug conjugates (ADCs) are transforming cancer care and with AI-powered pathology, doctors can now measure her HER2 more precisely to match patients with the best treatments. HostJennifer Smith-Parker, Director of Insights, BioSpaceGuestsDr. Rob Monroe, Vice President and Chief Scientific Officer, Oncology, Danaher Corporation; Chief Medical Officer, Leica BiosystemsJennifer Faikish, Vice President and Franchise Head, Oncology, Danaher CorporationDisclaimer: The views expressed in this discussion by guests are their own and do not represent those of their organizations.
Host: Yuval Zabar, MD Guest: Michelle Mielke, PhD Guest: Henrik Zetterberg, MD, PhD For the latest insights on tau and neurodegeneration biomarkers in Alzheimer's disease (AD), tune in to this recorded presentation featuring Doctor Michelle Mielke and Professor Henrik Zetterberg. Together, they delve into the role of tau in AD, exploring the ‘tau cascade', the current use of tau and neurodegeneration biomarkers in tracking disease progression, and how the AD biomarker landscape may evolve over time. Doctor Mielke is a Professor of Epidemiology and Neurology at the Wake Forest University School of Medicine, and Professor Zetterberg is a Professor of Neurochemistry at the University of Gothenburg. To learn more about tau in Alzheimer's disease, explore the Know Tau medical education platform. Know Tau is created and funded by Biogen and is intended for healthcare professionals only.
Balancing Careers and Family: Insights from Dr. Thomas HelmIn this episode of The Girl Doc Survival Guide, Christine invites Dr. Thomas Helm, MD, for his second appearance on the podcast. Dr. Helm, former Head of Dermatology and Director of Dermatopathology at Buffalo Medical Group, now working at Penn State Hershey Medical Center, shares his extensive experience and personal anecdotes. They discuss generational changes in the medical field, challenges faced by women in medicine, and the importance of work-life balance. Dr. Helm emphasizes the significance of understanding work culture, making intentional career decisions, and maintaining work-family harmony. He reflects on his career transition to academia and the rewarding relationships he has built along the way. The conversation delves into the importance of community, mentoring, and the profound impact of prioritizing meaningful relationships over individual autonomy.00:00 Introduction and Guest Welcome00:45 Personal Anecdotes and Family Influence01:22 Changes in Medical Field Demographics02:10 Challenges for Women in Medicine02:39 Balancing Career and Family04:50 Mentorship and Career Advice06:46 Prioritizing Relationships and Community10:53 Transition to Academia and Personal Growth18:52 Final Thoughts and Gratitude
Those who hope to honor God and advance Jesus' Kingdom face powerful opposition from spiritual, physical, and psychological enemies. Successful launching and long term fruitfulness depends on recognizing and, in dependence on the Holy Spirit, waging war against those enemies.
Welcome to Season 2 of the Orthobullets Podcast.In this episode, we review the high-yield topic of Metastatic Disease of Extremity from the Pathology section.Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
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Eric introduces the concept of "sales pathology", which he defines as a repeated pattern of dysfunction in how contractors communicate with potential clients. He argues that many professionals suffer from "speech disorders" in sales—such as inconsistent pacing, over-explaining, or sounding uncertain—which ultimately destroy trust and lead to lost revenue. By comparing these issues to physical ailments or speech impediments, he emphasizes that these behaviors require specialized diagnosis and rigorous training to correct. Triplett highlights live role-playing as the essential "prescription" for identifying these hidden flaws that marketing alone cannot fix. Furthermore, the discussion touches on leadership and legacy, exploring how contractors can grow their businesses while supporting the personal goals of their employees. Through community accountability, Eric aims to help contractors break through financial plateaus and achieve a better quality of life. Key Takeaways: Identify and address your personal "sales pathologies," which are repeated patterns of dysfunctional communication that can create distrust and lower your value with clients. Commit to regular role-play training with peers to expose and correct communication blind spots that you may not be able to identify on your own. Maintain a consistent tone and cadence throughout your sales conversations, ensuring you sound just as confident when discussing pricing as you do when explaining the technical scope of work. Prioritize improving your sales communication skills before increasing your marketing budget to ensure you don't waste new leads on a dysfunctional sales process. Surround yourself with a community or peer group that provides the necessary pressure and accountability to help you maintain high standards and continuous professional growth.
Send us a textThis session is a practical walkthrough of where digital pathology and AI truly stand in early 2026—based on five recent PubMed papers and real-world implementation experience.In this episode, I review new clinical adoption guidelines, AI applications in liver cancer imaging and pathology, AI-ready metadata for whole slide images, non-destructive tissue quality control from H&E slides, and machine learning–assisted IHC scoring in precision oncology.This conversation is not about hype. It's about standards, validation, data integrity, and clinical translation—the factors that decide whether AI tools stay in research or reach patient care.Episode Highlights01:21 – Practical digital pathology adoption guidelines (Polish Society of Pathologists)08:05 – AI in liver cancer imaging & pathology, and why framework alignment matters18:10 – AI-generated tissue maps as metadata for WSI archives23:01 – PathQC: predicting RNA integrity and autolysis from H&E slides32:14 – ML-assisted IHC scoring in genitourinary cancers29:42 – Digital Pathology 101 book + community updatesKey TakeawaysDigital pathology adoption still requires clear standards and validation workflowsAI performs best when aligned with existing diagnostic frameworks (e.g., LI-RADS)Metadata extraction is a low-effort, high-impact AI use caseSlide-based quality control can support biobanking and biomarker researchAutomated IHC scoring improves consistency—but adoption remains uneven globallyResources Mentioned Digital Pathology 101 (free PDF & audiobook)Publication Links: a. https://pubmed.ncbi.nlm.nih.gov/41618426/ b. https://pubmed.ncbi.nlm.nih.gov/41616271/ c. https://pubmed.ncbi.nlm.nih.gov/41610818/ d. https://pubmed.ncbi.nlm.nih.gov/41595938/ e. https://pubmed.ncbi.nlm.nih.gov/41590351/ Support the showGet the "Digital Pathology 101" FREE E-book and join us!
Dr. Bill Morice is the President and CEO of Mayo Clinic Laboratories and the former longtime Chair of Lab Medicine and Pathology at Mayo. This week Dr. Morice gets into the specifics of Guillain-Barre syndrome (also known as Acute Inflammatory Demyelinating Polyneuropathy) and Shingles. The Christopher Gabriel Program ----------------------------------------------------------- Please Like, Comment and Follow 'The Christopher Gabriel Program' on all platforms: The Christopher Gabriel Program is available on the KMJNOW app, Apple Podcasts, Spotify, YouTube or wherever else you listen to podcasts. --- The Christopher Gabriel Program | Website | Facebook | X | Instagram | --- Everything KMJ KMJNOW App | Podcasts | Facebook | X | Instagram See omnystudio.com/listener for privacy information.
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In this episode, Robert Corona, DO, MBA, FCAP, FASCP, John B. Henry Professor of Pathology and Chief Executive Officer at SUNY Upstate Medical University Hospital, joins the podcast to discuss reducing workplace violence, easing administrative burden through new technologies, and improving pathology operations with innovations such as drone-based transportation. He also shares where he sees opportunities for organizational growth as healthcare systems adapt to new operational and workforce challenges.
Medical missionaries often feel powerful emotional burden from moral injury, and it is a leading cause of departure from the mission field. But we have learned proven methods of preventing and dealing with moral injury. Use God’s powerful methods to protect yourself and your team, and to grow in wisdom and spirit!
When is active surveillance the right choice for intermediate-risk prostate cancer patients? In this episode of BackTable Urology, Dr. Claire de la Calle, Assistant Professor of Urology at the University of Washington, joins Dr. Ruchika Talwar to unpack how active surveillance has evolved beyond low-risk disease and why select Grade Group 2 patients may be appropriate candidates now with thoughtful patient selection. --- SYNPOSIS The conversation explores emerging tools that can refine surveillance decisions, including PSA density, MRI findings, genomic classifiers, and the growing role of AI-assisted pathology. Dr. de la Calle emphasizes the importance of nuanced patient counseling, acknowledging anxiety and long-term risk while reinforcing that time on active surveillance can be a meaningful win when oncologic outcomes remain comparable to upfront treatment. --- TIMESTAMPS 00:00 - Introduction02:58 - Current Evidence05:03 - Patient Selection Criteria12:11 - Importance of PSA Density and Monitoring Protocols18:12 - Pathology and Genomic Testing32:18 - Future Directions and Research36:33 - Key Takeaways --- RESOURCES ProtecT Trial: Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancerhttps://www.nejm.org/doi/full/10.1056/NEJMoa2214122 Canary PASS Studyhttps://canarypass.org/ Genomic Classifier Performance in Intermediate-Risk Prostate Cancer: Results From NRG Oncology/RTOG 0126 Randomized Phase 3 Trialhttps://pubmed.ncbi.nlm.nih.gov/37137444
Andrew Beck, MD, PhD is the Co-founder and CEO of PathAI, where he and his team are developing AI tools to improve the precision of pathology and the efficacy of drug development for diagnosis of cancer and also many other complex diseases.Before founding PathAI, Andrew was an Associate Professor at Harvard Medical School, where his research focused on the application of machine learning to cancer pathology. He earned his MD from Brown University and his PhD in Biomedical Informatics from Stanford University, where he pioneered some of the first computational models used to predict patient outcomes in oncology.Time stamps of the conversation:00:00:00 Highlights00:01:28 Introduction00:02:18 Entrypoint in AI00:07:02 Background in Medicine and Bioinformatics 00:10:00 Leap from academia to entrepreneurship00:16:20 Translating AI developments to Pathology00:21:15 Specialist vs Generalist AI models in medicine00:24:15 What sets PathAI apart?00:26:32 AI adoption medicine00:34:25 Usage of AI tools in clinical workflows, example MASH00:40:10 AI in Dermatopathology00:42:15 AI for biomarker discovery00:47:05 Will AI models replace pathologists?00:52:28 Avoiding over-reliance on AI00:57:40 Is AI living unto the hype?01:01:00 Challenges in clinical trials 01:05:12 AI reaching patients directly01:09:50 Working at intersection of AI & Healthcare01:15:30 Pitfalls to learn fromMore about PathAI: https://www.pathai.com/and Andy: https://www.pathai.com/about-us/andy-beckAbout the Host:Jay is a Machine Learning Engineer III at PathAI working on improving AI for medical diagnosis and prognosis. Linkedin: https://www.linkedin.com/in/shahjay22/Twitter: https://twitter.com/jaygshah22Homepage: https://jaygshah.github.io/ for any queries.Stay tuned for upcoming webinars!***Disclaimer: The information in this video represents the views and opinions of the speaker and does not necessarily represent the views or opinions of any institution. It does not constitute an endorsement by any Institution or its affiliates of such video content.***
Cathy interviews Zoe Larsen Morgese, an experienced SLP. Zoe and Cathy discuss the importance of early communication between caregivers and young children with blindness and low vision. Zoe shares her longtime experience learning about communication of the young child during mealtimes through a federal IES research project and as an SLP for educational programs across the country. Zoe discusses the importance of learning to read children's cues to encourage successful, enjoyable mealtimes. She recommends further reading through Ellyn Satter's Child of Mine book and the Ellyn Satter Institute and a parent friendly organization called Feeding Matters at https://www.feedingmatters.org/who-we-are/ where you can find support, information, and research. Another excellent resource is the Facebook Page “Kid's Eat in Color” which is managed by a child nutritionist. For those who would like to see the touching “family time” video about eating together that Zoe and Cathy discussed, here is the link: https://www.youtube.com/watch?v=P9ZMZBSa9q8&t=5s Jenny, Cathy & Paige discuss how important establishing beginning, middle and ending routines are for infants and toddlers throughout the day, particularly for young children with blindness and low vision. These early communication efforts lead to joint attention, anticipation, vocabulary development, and choice-making skills. Jenny and Paige emphasize that these efforts can be easily incorporated into family life. We love voicemail! Please leave us a message: https://www.speakpipe.com/FeelingThisLife Children who are blind and low “Vision AND” have additional needs may receive early intervention services from multiple professionals. A list of those services can be found here. Please give us your feedback using this survey link: https://educationutah.co1.qualtrics.com/jfe/form/SV_39OmBvMih6MlgNw Make a Donation to- VIPS: https://secure.vips.org/np/clients/vips/donation.jsp?forwardedFromSecureDomain=1&campaign=495 Follow us on Facebook @Feelingthislifepodcast and Instagram @Feelingthislife Email: feelingthislife@vips.org www.vips.org
In this episode, Dr. Alejandro Olmedo-Velarde, Assistant Professor of Host-Microbe Interactions in the Department of Plant Pathology, Entomology and Microbiology at Iowa State University in Ames, Iowa joins host Matt Kasson to discuss his lab's research program on multi-trophic interactions in vector-borne diseases in corn, soybean, and other crops. He also discusses growing up in Ecuador, his time working on numerous tropical plant viruses in Hawaii and transitioning to working with fastidious prokaryotes and diverse disease vectors. *show notes * Dr. Olmedo-Velarde's Iowa State University profile: https://www.ppem.iastate.edu/people/alejandro-olmedo-velarde Dr. Olmedo-Velarde's lab website: https://faculty.sites.iastate.edu/aolmedov/ Dr. Olmedo-Velarde's google scholar page: https://scholar.google.com/citations?user=rBzKiKQAAAAJ&hl=en&oi=ao This episode is produced by Association Briefings. Special Guest: Alejandro Olmedo-Velarde.
If you've ever wondered, “What's actually real when it comes to UAPs, aliens, and nonhuman intelligence?”...today, you're getting real answers. This episode of Mayim Bialik's Breakdown cuts through decades of speculation, misinformation, and stigma to bring you hard science, firsthand research, and never-before-shared insights from one of the most credible scientists studying UAPs today. For years, the public has been left guessing—Are UFOs real? Are aliens visiting us? Are people actually being harmed? And why won't mainstream science touch this topic? That changes today. We're sitting down with Dr. Garry Nolan, Professor of Pathology at Stanford University School of Medicine, Co-Founder and Executive Director of the Sol Foundation (a leading research institute focused on Unidentified Aerial Phenomena), and a featured expert in the hit documentary The Age of Disclosure. Dr. Nolan explains how he scientifically proved the infamous Atacama “alien” skeleton was not extraterrestrial, revealing what the DNA of true nonhuman life might actually look like if we ever encounter it. We also explore his classified-adjacent work studying UAPs, including deeply unsettling cases of alleged human injuries linked to possible UAP encounters and energy weapons, and the shocking implications these cases may have for regions of the human brain tied to intuition, perception, and consciousness itself. Dr. Nolan shares what he's uncovered from analyzing alleged UAP artifacts, including materials connected to Roswell, and how his lab studies metal fragments containing anomalies that appear to defy known physics. This episode goes where most won't—and does so with data, restraint, and scientific rigor. We're breaking down: - Why the Atacama “alien” skeleton fooled the world, and how science finally solved it - What alien or nonhuman DNA would actually look like (and why Hollywood gets it wrong) - What UAP-related human injury cases may reveal about the brain, intuition, and perception - How alleged UFO materials and Roswell fragments are analyzed at the atomic level - What Dr. Nolan believes the true goal of nonhuman intelligence might be - Why he thinks aliens should allow humanity to evolve naturally before further interference - What he personally witnessed as a child involving UAPs and nonhuman intelligence - How he responds to skepticism and backlash from fellow scientists - And whether humanity faces a physical or existential risk from alien contact This is not science fiction. This is cutting-edge science colliding with the biggest mystery of all time. Once you hear this, you may never look at reality the same way again. The Sol Foundation: http://www.thesolfoundation.org Follow us on Substack for Exclusive Bonus Content: https://bialikbreakdown.substack.com/ BialikBreakdown.com YouTube.com/mayimbialik Learn more about your ad choices. Visit megaphone.fm/adchoices
In Conversation with Dr. Wolfgang Weyers: The Complexities of Dermatopathology DiagnosisIn this episode of The Girl Doc Survival Guide, Christine welcomes Dr. Wolfgang Weyers, a highly respected dermatopathologist and author, to discuss his experience and perspectives on medical diagnosis. Dr. Weyers shares a personal anecdote about his influential mentor, Dr. Bernie Ackerman, and dives into a critical discussion on overdiagnosis, the importance of specific diagnosis in dermatopathology, problems caused by partial samples, and the criteria for diagnosing melanoma. He emphasizes the importance of experience, proper training, and the need to biopsy adequately developed lesions. The conversation also touches on the complexity of biological classification and the role of behavior and molecular studies in understanding diseases. 00:00 Introduction to Dr. Wolfgang Weyers00:46 Personal Anecdotes and Influences02:05 Discussion on Overdiagnosis05:04 Criteria for Melanoma Diagnosis08:34 Challenges in Diagnosis and Solutions16:48 Final Thoughts and Conclusion
If you've ever wondered, “What's actually real when it comes to UAPs, aliens, and nonhuman intelligence?”...today, you're getting real answers. This episode of Mayim Bialik's Breakdown cuts through decades of speculation, misinformation, and stigma to bring you hard science, firsthand research, and never-before-shared insights from one of the most credible scientists studying UAPs today. For years, the public has been left guessing—Are UFOs real? Are aliens visiting us? Are people actually being harmed? And why won't mainstream science touch this topic? That changes today. We're sitting down with Dr. Garry Nolan, Professor of Pathology at Stanford University School of Medicine, Co-Founder and Executive Director of the Sol Foundation (a leading research institute focused on Unidentified Aerial Phenomena), and a featured expert in the hit documentary The Age of Disclosure. Dr. Nolan explains how he scientifically proved the infamous Atacama “alien” skeleton was not extraterrestrial, revealing what the DNA of true nonhuman life might actually look like if we ever encounter it. We also explore his classified-adjacent work studying UAPs, including deeply unsettling cases of alleged human injuries linked to possible UAP encounters and energy weapons, and the shocking implications these cases may have for regions of the human brain tied to intuition, perception, and consciousness itself. Dr. Nolan shares what he's uncovered from analyzing alleged UAP artifacts, including materials connected to Roswell, and how his lab studies metal fragments containing anomalies that appear to defy known physics. This episode goes where most won't—and does so with data, restraint, and scientific rigor. We're breaking down: - Why the Atacama “alien” skeleton fooled the world, and how science finally solved it - What alien or nonhuman DNA would actually look like (and why Hollywood gets it wrong) - What UAP-related human injury cases may reveal about the brain, intuition, and perception - How alleged UFO materials and Roswell fragments are analyzed at the atomic level - What Dr. Nolan believes the true goal of nonhuman intelligence might be - Why he thinks aliens should allow humanity to evolve naturally before further interference - What he personally witnessed as a child involving UAPs and nonhuman intelligence - How he responds to skepticism and backlash from fellow scientists - And whether humanity faces a physical or existential risk from alien contact This is not science fiction. This is cutting-edge science colliding with the biggest mystery of all time. Once you hear this, you may never look at reality the same way again. Head to https://impact.ourritual.com/6yr65V , take a quick quiz, and use code BREAKER20 for 20% off your first month. Let Rocket Money help you reach your financial goals faster. Join at rocketmoney.com/breakdown Sign up for your $1 per month trial and start selling today at https://shopify.com/breakdown The Sol Foundation: http://www.thesolfoundation.org Follow us on Substack for Exclusive Bonus Content: https://bialikbreakdown.substack.com/ BialikBreakdown.com YouTube.com/mayimbialik Learn more about your ad choices. Visit megaphone.fm/adchoices
The ABMP Podcast | Speaking With the Massage & Bodywork Profession
Ruth is learning, writing, and teaching about thyroid disease in lots of different places, so IHACW is coming along for the ride. Hypothyroidism: the thyroid gland doesn't produce enough of the right hormones to stimulate healthy metabolism—a person has a hard time turning fuel (that's oxygen and food) into energy. The result: lethargy, weight gain, sluggish digestion, and lots, lots more. Does this describe any of your clients? But treating endocrine diseases is a tricky business. In this episode Ruth interviews a friend who had some success, but it is an ongoing battle. Resources: Allen, E. and Fingeret, A. (2025) "Anatomy, Head and Neck, Thyroid," in StatPearls. Treasure Island (FL): StatPearls Publishing. Available at: http://www.ncbi.nlm.nih.gov/books/NBK470452/ (Accessed: January 1, 2026). Elshimy, G. et al. (2025) "Myxedema Coma," in StatPearls. Treasure Island (FL): StatPearls Publishing. Available at: http://www.ncbi.nlm.nih.gov/books/NBK545193/ (Accessed: January 8, 2026). Lu, M. et al. (2025) "Therapeutic benefits of acupoint massage at Yuji (LU10) and Zhaohai (KI6) for postoperative hoarseness in thyroid surgery patients," BMC surgery, 25(1), p. 148. Available at: https://doi.org/10.1186/s12893-025-02889-7. Rosen, J.E. et al. (2013) "Complementary and alternative medicine use among patients with thyroid cancer," Thyroid: Official Journal of the American Thyroid Association, 23(10), pp. 1238–1246. Available at: https://doi.org/10.1089/thy.2012.0495. Tachi, J., Amino, N. and Miyai, K. (1990) "Massage therapy on neck: a contributing factor for destructive thyrotoxicosis?," Thyroidology, 2(1), pp. 25–27. Thyroid Nodules: Causes, Symptoms & Treatment (no date) Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/13121-thyroid-nodule (Accessed: January 8, 2026). Thyroid: What It Is, Function & Problems (no date). Available at: https://my.clevelandclinic.org/health/body/23188-thyroid (Accessed: January 1, 2026). Wyne, K.L. et al. (2023) "Hypothyroidism Prevalence in the United States: A Retrospective Study Combining National Health and Nutrition Examination Survey and Claims Data, 2009–2019," Journal of the Endocrine Society, 7(1), p. bvac172. Available at: https://doi.org/10.1210/jendso/bvac172. Sponsors: Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function. Website: anatomytrains.com Email: info@anatomytrains.com Facebook: facebook.com/AnatomyTrains Instagram: www.instagram.com/anatomytrainsofficial YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA Precision Neuromuscular Therapy seminars (www.pnmt.org) have been teaching high-quality seminars for more than 20 years. Doug Nelson and the PNMT teaching staff help you to practice with the confidence and creativity that comes from deep understanding, rather than the adherence to one treatment approach or technique. Find our seminar schedule at pnmt.org/seminar-schedule with over 60 weekends of seminars across the country. Or meet us online in the PNMT Portal, our online gateway with access to over 500 videos, 37 NCBTMB CEs, our Discovery Series webinars, one-on-one mentoring, and much, much more! All for the low yearly cost of $167.50. Learn more at pnmt.thinkific.com/courses/pnmtportal! Follow us on social media: @precisionnmt on Instagram or at Precision Neuromuscular Therapy Seminars on Facebook. Heights Wellness Retreat is redefining whole-body wellness through an innovative, integrated approach to physical, mental, and emotional well-being. Built on more than two decades of Massage Heights expertise in massage and skin therapy, this next-generation wellness destination represents the evolution of our mission to transform lives through wellness. At Heights Wellness Retreat, we believe every person is an unstoppable force, whether navigating daily demands, pursuing goals, or striving to be their best. This drives everything we do. We go beyond traditional spa services by creating a purpose-driven environment where wellness professionals are empowered, valued, and positioned to grow. With steady clientele, support, and a wellness-forward culture, Heights Wellness Retreat is where therapists build meaningful, sustainable careers while shaping the future of the wellness industry. www.massageheightscareers.careerplug.com/jobs www.heightswellnessretreats.com https://www.instagram.com/heightswellnessretreat/ https://www.facebook.com/heightswellnessretreat/
Support the Institute today. https://givenow.nova.edu/the-institute-for-neuro-immune-medicine-inim-2025 In this episode, Haylie Pomroy speaks with Dr. Theoharis Theoharides about multiple chemical sensitivity (MCS). He explains the immunological responses occurring within the body, the symptoms and daily experiences reported by patients, and the connection between MCS and mast cell activation. Dr. Theoharides also offers expert guidance on managing MCS, explains the diagnostic codes associated with mast cell activation, and emphasizes why blocking mast cells is critical to the healing process. He further discusses how stress can trigger mast cell reactivation, the role of vitamin D3, and why measuring chemical exposures and mycotoxins does not always indicate the absence of ongoing immune reactivation. Dr. Theoharis Theoharides is a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine-Clearwater, an Adjunct Professor of Immunology at Tufts School of Medicine, where he was a Professor of Pharmacology and Internal Medicine, and also the Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist at the Massachusetts Drug Formulary Commission (1983-2022). He received his BA, MS, MPhil, PhD, and MD degrees and the Winternitz Price in Pathology from Yale University and received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy School of Government. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award, "recognizing excellence, compassion, and service." Dr. Theoharides has 485 publications (46,491 citations; h-index 106), placing him in the world's top 2% of most cited authors, and he was rated the worldwide expert on mast cells by Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame, and the World Academy of Sciences. Website: https://www.drtheoharides.com LinkedIn: linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735 Instagram: https://www.instagram.com/dr.theoharides/ Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet. Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com Instagram: https://www.instagram.com/hayliepomroy Facebook: https://www.facebook.com/hayliepomroy YouTube: https://www.youtube.com/@hayliepomroy/videos LinkedIn: https://www.linkedin.com/in/hayliepomroy/ X: https://x.com/hayliepomroy Sign up today for our newsletter. https://nova.us4.list-manage.com/subscribe?u=419072c88a85f355f15ab1257&id=5e03a4de7d This podcast is brought to you by the Institute for Neuro-Immune Medicine. Learn more about us here. Website: https://www.nova.edu/nim/ Facebook: https://www.facebook.com/InstituteForNeuroImmuneMedicine Instagram: https://www.instagram.com/NSU_INIM/ Twitter: https://www.twitter.com/NSU_INIM
Welcome to Season 2 of the Orthobullets Podcast.Today's show is CoinFlips, where expert speakers discuss grey zone decisions in orthopedic surgery. This episode will feature doctors Surena Namdari, Jonathan Levy, Bryan Saltzman, & Derek Cuff. They will discuss the case titled "Shoulder Pain and Stiffness s/p Acromion ORIF in 65F."Follow Orthobullets on Social Media:FacebookInstagramTwitterLinkedInYouTube
Hidden Killers With Tony Brueski | True Crime News & Commentary
Dr. Meghan Kessler, Forensics Pathologist, testified today in the Brendan Banfield murder trial. Banfield, a former IRS agent, is charged with four counts of aggravated murder in the February 2023 deaths of his wife Christine Banfield and Joseph Ryan at their Herndon, Virginia home.Prosecutors allege Banfield plotted the killings with the family's Brazilian au pair, Juliana Peres Magalhães, with whom he was having an affair. Magalhães has pleaded guilty to manslaughter and is expected to testify against Banfield. The defense maintains digital evidence does not support the state's catfishing theory.#BrendanBanfield #AuPairAffair #MurderTrial #TrueCrime #Testimony #ChristineBanfield #JosephRyan #FairfaxCounty #HiddenKillers #BreakingJoin Our SubStack For AD-FREE ADVANCE EPISDOES & EXTRAS!: https://hiddenkillers.substack.com/Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspodInstagram https://www.instagram.com/hiddenkillerspod/Facebook https://www.facebook.com/hiddenkillerspod/Tik-Tok https://www.tiktok.com/@hiddenkillerspodX Twitter https://x.com/tonybpodListen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872This publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.
John and Craig consider all the words they have to write and ask, how do you know when something deserves your best effort? They offer a useful rubric for deciding when something is worth perfecting, and when over-optimization is a waste of time. We also follow up on compulsive writing habits, industry euphemisms, back issues, and the impact and legacy of the WGA's 2019 agency negotiations. In our bonus segment for premium members, it's a new year! John looks back at things he accomplished in 2025 and his goals for 2026, while Craig sighs and gestures in the direction of The Last of Us. Links: Jamie Lee Curtis says "Trauma" Concept Creep: Psychology's Expanding Concepts of Harm and Pathology by Nick Haslam Young Connor Storrie on YouTube Steve Jobs introduces the iPhone Elon Musk announces the Cybertruck Valentina Vee on TikTok and Instagram Birth by Madison Karrh John's What I Did in 2025 Get your copy of the Scriptnotes book! Get a Scriptnotes T-shirt! Check out the Inneresting Newsletter Become a Scriptnotes Premium member, or gift a subscription Subscribe to Scriptnotes on YouTube Scriptnotes on Instagram John August on Bluesky and Instagram Outro by Eric Pearson (send us yours!) Scriptnotes is produced by Drew Marquardt and edited by Matthew Chilelli. Email us at ask@johnaugust.com You can download the episode here.