Podcasts about Epilepsy

Epilepsy is the fourth most common neurological disorder, with 1 in 26 Americans experiencing some form of in their lifetimes. Christopher Jones has the condition, and one hell of a survival story.Become a supporter of this podcast: https://www.spreaker.com/podcast/true-stories-with-seth-andrews--5621867/support.

Join Jay Gunkelman, QEEGD (the man who has analyzed over 500,000 brain scans), Dr. Mari Swingle (author of i-Minds and developer of Swingle Sonic Apps), and host Pete Jansons for another engaging NeuroNoodle Neurofeedback Podcast episode discussing neuroscience, psychology, mental health, and brain training.✅ Topic 1 Explained: Concussion risk and gender differences in sports—why female athletes face higher risks and what adaptations can help.✅ Topic 2 Deep Dive: 40 Hz Gamma (“Neureka”) training—benefits, risks, and what persistent gamma can signal in epilepsy, lesions, and movement disorders.✅ Topic 3 Insights: Mislearning vs. true learning disabilities—how EEG markers reveal critical distinctions and improve outcomes.✅ Additional Topics:

Tom Ackerman and Jim Brennan recap the Dance for Dravet fundraiser, which brought together more than 500 attendees and raised over $900,000 to support research for Dravet syndrome, a rare form of epilepsy. The event surpassed its goal of raising a cumulative $1 million, driven by the generosity of the St. Louis community. Jim also shared updates from McKelvey Homes, which will donate $1,898 for every home sold in the fourth quarter to the ACA Affordable Housing Fund, now awarding more than $2 million in grants. The conversation wraps with plans for future charitable initiatives and community development projects.

In this episode we speak with three runners from Team Abbott — a community of runners who have faced serious health challenges but didn't let those challenges define them! [powerpress] About Our Guests Elizabeth Pehota (Boston, MA): Three days out from running the 2022 Berlin Marathon, Elizabeth Pehota experienced a feeling of pins and needles in her hands, feet and thighs, and an unnatural resistance while running. Soon after, she was diagnosed with Multiple Sclerosis (MS), a chronic, unpredictable disease of the central nervous system. As someone who shares her daily life on social media, Elizabeth, @healthy_cheers on Instagram, only recently opened up about her diagnosis, but has already formed relationships with other MS patients around the world. Elizabeth is an Abbott World Marathon Major Six Star Finisher and received her seventh star in Sydney. Ed Barnes (Douglas, MA): Ed was born with a congenital heart condition and at age 15 he started to experience frequent dizziness - to the point of nearly passing out - leading him to undergo open heart surgery to receive an Abbott artificial aortic heart valve. This year, after completing the Boston Marathon, Ed became the first person with an artificial heart valve to finish all seven Abbott World Marathon Majors.   Mary Tawney Suarez (Fullerton, CA): Just before the pandemic, Mary started experiencing seizures and was diagnosed with Epilepsy and a brain cyst. One year later, she started experiencing back pain and numbness in her legs, which was revealed to be the degeneration of the cerebral and lower part of her spine. Despite these obstacles, Mary has continued running, and just finished the Berlin Marathon. [box] Links Mentioned in This Episode Run Coaching. Work with an expert MTA running Coach. MetPro.co -For the first time ever, MetPro is offering MTA listeners a full 30-day experience for just $95 with absolutely no strings attached! See what it's like working with your own metabolic coach. Limited to the first 30 people. AG1 Next Gen has new flavors: new flavors: Citrus, Tropical, and Berry. Get a free Welcome Kit with your first order which includes 5 AG1 Travel Packs, a shaker bottle, metal canister, and a bottle of AG Vitamin D3+K2. The Virginia Credit Union River City Half -March 7 in Richmond, Virginia. Drury Hotels -Get 10% off your stay with our link or use the code RN2025. Team Abbott -a community of runners, many of whom have overcome health challenges, who are committed to inspiring others through their running journeys. To submit your story for a chance to join Team Abbott, visit abbott.com/marathons. [/box]

In this episode, editor in chief Joseph E. Safdieh, MD, FAAN, highlights articles about pegivirus's potential role in Parkinson's disease pathology, the impact of GLP-1 receptor agonistst on idiopathic intracranial hypertension, and the geographic spread of epilepsy specialists.

Billy's still flat about the Cats, but he tries to lift for the All Sports report as a big name Dee tells the club he wants out. Aussie cricketer Beth Mooney calls in from India ahead of the Women's World Cup, then Topics Brayshaw wants to know what you've had to do after losing a bet. Billywood makes a return with the latest showbiz news, and we recap Billy's poor performance during the first half of the show. Adelaide Crows board member Neil Balme is in studio reflecting on winning Premierships as a player, coach, and administrator - and he's raising awareness for the Walk for Epilepsy. Finally, Billy has a joke that probably hits a bit close to home. See omnystudio.com/listener for privacy information.

See omnystudio.com/listener for privacy information.

This week, Bobbi Conner talks with MUSC's Dr. Janelle Wagner about behavioral health interventions for children with epilepsy.

The show begins with a charity concert in Madison WI to benefit the Joey's Song foundation. Steve Porcaro from Toto, Jane Weidlen from The Go Go's, Butch Vig from Garbage, and more will perform the weekend of Jan 9th and 10th to raise money for Epilepsy Awareness. Other segments include; the top ten cities in […]

Do you feel like a dummy sometimes? Are you someone living with epilepsy, caregiving for someone with epilepsy, or want to know what to do in case you have to administer aid to someone having a seizure? Are you a teacher, coach, family member or friend of somebody who has epilepsy and you feel uninformed about epilepsy and wish there was a comprehensive guide for... well.. dummies? FINALLY, the book that everybody needs has arrived! From Wiley, the makers of the "For Dummies" series of books, comes a new installment:  Epilepsy for Dummies! Your complete guide to understanding all aspects of the epilepsy journey. Greg sits down with the authors of this book - Dr. Elizabeth Thiel, a neurologist and epileptologist, and Lauren Aguirre, an author, journalist, epilepsy patient and caregiver to her children that also have epilepsy - for a very special TWO PART series that dives into the book and the process of writing it. In part one, they discuss the inspiration for writing it, the rapidly-expanding knowledge of epilepsy and potential genetic causes of seizures, wearable technology and the future of epilepsy treatment, qualities of a doctor that patients value, and so much more! There is so much expertise between these two authors, you NEED this book and this podcast! Pre-order Epilepsy for Dummies now, or own it immediately in digital format! Talk About It with Greg Grunberg is excited to be sponsored by Neurelis and by Jazz Pharmaceuticals.

In this week's episode, Brain & Life Podcast host Dr. Daniel Correa is joined by Tiffany Kairos, an epilepsy advocate and founder of the Epilepsy Network, and her husband Chris Kairos. Tiffany shares her journey of living with epilepsy and her recent diagnosis of Functional Neurologic Disorder (FND). Tiffany and Chris delve into their experience managing both conditions, the impact on daily life, and the support systems that help her navigate these experiences. Dr. Correa is then joined by Dr. W. Curt LaFrance, Inaugural Director of Neuropsychiatry and Behavioral Neurology at Rhode Island Hospital, Director of the VA Mind Brain program, and Professor of Psychiatry and Neurology at Brown University. Dr. LaFrance discusses the complexities of FND, the importance of integrating neurology and psychiatry for effective diagnosis and treatment, and the evolution of terminology to reduce stigma and improve patient engagement.   Additional Resources The Epilepsy Network (TEN) What is Functional Neurologic Disorder? Taking Control of Your Seizures Epilepsy Foundation The Anita Kaufman Foundation   Other Brain & Life Podcast Episodes on These Topics JenVon Cherry on Educating Communities of Color About Epilepsy Actor Cameron Boyce's Legacy and Raising Awareness About SUDEP Tiffany Kairos on Finding Her Voice in Epilepsy Advocacy   We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? ·       Record a voicemail at 612-928-6206 ·       Email us at BLpodcast@brainandlife.org   Social Media:   Guests: Tiffany Kairos @TiffanyKairos @theepilepsynetwork; Chris Kairos @ka1ro5; Dr. W. Curt LaFrance @brownuniversityhealth Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD

Paroxysmal movement disorders refer to a group of highly heterogeneous disorders that present with attacks of involuntary movements without loss of consciousness. These disorders demonstrate considerable and ever-expanding genetic and clinical heterogeneity, so an accurate clinical diagnosis has key therapeutic implications. In this episode, Kait Nevel, MD, speaks with Abhimanyu Mahajan, MD, MHS, FAAN, author of the article “Paroxysmal Movement Disorders” in the Continuum® August 2025 Movement Disorders issue. Dr. Nevel is a Continuum® Audio interviewer and a neurologist and neuro-oncologist at Indiana University School of Medicine in Indianapolis, Indiana. Dr. Mahajan is an assistant professor of neurology and rehabilitation medicine at the James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders at the University of Cincinnati in Cincinnati, Ohio. Additional Resources Read the article: Paroxysmal Movement Disorders Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @IUneurodocmom Guest: @MahajanMD Full episode transcript available here Dr Jones: This is Doctor Lyell Jones, editor in chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Nevel: Hello, this is Dr Kait Nevel. Today I'm interviewing doctor Abhi Mahajan about his article on diagnosis and management of paroxysmal movement disorders, which appears in the August 2025 Continuum issue on movement disorders. Abhi, welcome to the podcast and please introduce yourself to the audience. Dr Mahajan: Thank you, Kait. Thank you for inviting me. My name is Abhi Mahajan. I'm an assistant professor of neurology and rehabilitation medicine at the University of Cincinnati in Cincinnati, Ohio. I'm happy to be here. Dr Nevel: Wonderful. Well, I'm really excited to talk to you about your article today on this very interesting and unique set of movement disorders. So, before we get into your article a little bit more, I think just kind of the set the stage for the discussion so that we're all on the same page. Could you start us off with some definitions? What are paroxysmal movement disorders? And generally, how do we start to kind of categorize these in our minds? Dr Mahajan: So, the term paroxysmal movement disorders refers to a group of highly heterogeneous disorders. These may present with attacks of involuntary movements, commonly a combination of dystonia and chorea, or ataxia, or both. These movements are typically without loss of consciousness and may follow, may follow, so with or without known triggers. In terms of the classification, these have been classified in a number of ways. Classically, these have been classified based on the trigger. So, if the paroxysmal movement disorder follows activity, these are called kinesigenic, paroxysmal, kinesigenic dyskinesia. If they are not followed by activity, they're called non kinesigenic dyskinesia and then if they've followed prolonged activity or exercise they're called paroxysmal exercise induced dyskinesia. There's a separate but related group of protogynous movement disorders called episodic attacks here that can have their own triggers. Initially this was the classification that was said. Subsequent classifications have placed their focus on the ideology of these attacks that could be familiar or acquired and of course understanding of familiar or genetic causes of paroxysmal movement disorders keeps on expanding and so on and so forth. And more recently, response to pharmacotherapy and specific clinical features have also been introduced into the classification. Dr Nevel: Great, thank you for that. Can you share with us what you think is the most important takeaway from your article for the practicing neurologist? Dr Mahajan: Absolutely. I think it's important to recognize that everything that looks and sounds bizarre should not be dismissed as malingering. Such hyperkinetic and again in quotations, “bizarre movements”. They may appear functional to the untrained eye or the lazy eye. These movements can be diagnosed. Paroxysmal movement disorders can be diagnosed with a good clinical history and exam and may be treated with a lot of success with medications that are readily available and cheap. So, you can actually make a huge amount of difference to your patients' lives by practicing old-school neurology. Dr Nevel: That's great, thank you so much for that. I can imagine that scenario does come up where somebody is thought to have a functional neurological disorder but really has a proximal movement disorder. You mentioned that in your article, how it's important to distinguish between these two, how there can be similarities at times. Do you mind giving us a little bit more in terms of how do we differentiate between functional neurologic disorder and paroxysmal movement disorder? Dr Mahajan: So clinical differentiation of functional neurological disorder from paroxysmal movement disorders, of course it's really important as a management is completely different, but it can be quite challenging. There's certainly an overlap. So, there can be an overlap with presentation, with phenomenology. Paroxysmal nature is common to both of them. In addition, FND and PMD's may commonly share triggers, whether they are movement, physical exercise. Other triggers include emotional stimuli, even touch or auditory stimuli. What makes it even more challenging is that FND's may coexist with other neurological disorders, including paroxysmal movement disorders. However, there are certain specific phenom phenotypic differences that have been reported. So specific presentations, for example the paroxysms may look different. Each paroxysm may look different in functional neurological disorders, specific phenotypes like paroxysmal akinesia. So, these are long duration episodes with eyes closed. Certain kinds of paroxysmal hyperkinesia with ataxia and dystonia have been reported. Of course. More commonly we see PNES of paroxysmal nonepileptic spells or seizures that may be considered paroxysmal movement disorders but represent completely different etiology which is FND. Within the world of movement disorders, functional jerks may resemble propiospinal myoclonus which is a completely different entity. Overall, there are certain things that help separate functional movement disorders from paroxysmal movement disorders, such as an acute onset variable and inconsistent phenomenology. They can be suggestibility, distractibility, entrainment, the use of an EMG may show a B-potential (Bereitschaftspotential) preceding the movement in patients with FND. So, all of these cues are really helpful. Dr Nevel: Great, thanks. When you're seeing a patient who's reporting to these paroxysmal uncontrollable movements, what kind of features of their story really tips you off that this might be a proximal movement disorder? Dr Mahajan: Often these patients have been diagnosed with functional neurological disorders and they come to us. But for me, whenever the patient and or the family talk about episodic movements, I think about these. Honestly, we must be aware that there is a possibility that the movements that the patients are reporting that you may not see in clinic. Maybe there are obvious movement disorders. Specifically, there's certain clues that you should always ask for in the history, for example, ask for the age of onset, a description of movements. Patients typically have videos or families have videos. You may not be able to see them in clinic. The regularity of frequency of these movements, how long the attacks are, is there any family history of or not? On the basis of triggers, whether, as I mentioned before, do these follow exercise? Prolonged exercise? Or neither of the above? What is the presentation in between attacks, which I think is a very important clinical clue. Your examination may be limited to videos, but it's important not just to examine the video which represents the patient during an attack, but in between attacks. That is important. And of course, I suspect we'll get to the treatment, but the treatment can follow just this part, the history and physical exam. It may be refined with further testing, including genetic testing. Dr Nevel: Great. On the note of genetic testing, when you do suspect a diagnosis of paroxysmal movement disorder, what are some key points for the provider to be aware of about genetic testing? How do we go about that? I know that there are lots of different options for genetic testing and it gets complicated. What do you suggest? Dr Mahajan: Traditionally, things were a little bit easier, right, because we had a couple of genes that have been associated with the robust movement disorders. So, genetic testing included single gene testing, testing for PRRT2 followed by SLC2A. And if these were negative, you said, well, this is not a genetic ideology for paroxysmal movement disorders. Of course, with time that has changed. There's an increase in known genes and variants. There is increased genetic entropy. So, the same genetic mutation may present with many phenotypes and different genetic mutations may present with the similar phenotype. Single gene testing is not a high yield approach. Overall genetic investigations for paroxysmal movement disorders use next generation sequencing or whole exome sequence panels which allow for sequencing of multiple genes simultaneously. The reported diagnostic yield with let's say next generation sequencing is around 35 to 50 percent. Specific labs at centers have developed their own panels which may improve the yield of course. In children, microarray may be considered, especially the presentation includes epilepsy or intellectual disability because copy number variations may not be detected by a whole exome sequencing or next generation sequencing. Overall, I will tell you that I'm certainly not an expert in genetics, so whenever you're considering genetic testing, if possible, please utilize the expertise of a genetic counsellor. Families want to know, especially as an understanding of the molecular underpinnings and knowledge about associated mutations or variations keeps on expanding. We need to incorporate their expertise. A variant of unknown significance, which is quite a common result with genetic testing, may not be a variant of unknown significance next year may be reclassified as pathogenic. So, this is extremely important. Dr Nevel: Yeah. That's such a good point. Thank you. And you just mentioned that there are some genetic mutations that can lead to multiple different phenotypes. Seemingly similar phenotypes can be associated with various genetic mutations. What's our understanding of that? Do we have an understanding of that? Why there is this seeming disconnect at times between the specific genetic mutation and the phenotype? Dr Mahajan: That is a tough question to answer for all paroxysmal movement disorders because the answer may be specific to a specific mutation. I think a great example is the CACNA1A mutation. It is a common cause of episodic ataxia type 2. Depending on when the patient presents, you can have a whole gamut of clinical presentations. So, if the patient is 1 year old, the patient can present with epileptic encephalopathy. Two to 5 years, it can be benign paroxysmal torticollis of infancy. Five to 10 years, can present with learning difficulties with absence epilepsy and then of course later, greater than 10 years, with episodic ataxia (type) 2 hemiplegic migraine and then a presentation with progressive ataxia and hemiplegic migraines has also been reported. So not just episodic progressive form of ataxia has also been reported. I think overall these disorders are very rare. They are even more infrequently diagnosed than their prevalence. As such, the point that different genetic mutations present with different phenotypes, or the same genetic mutation I may present with different phenotypes could also represent this part. Understanding of the clinical presentation is really incomplete and forever growing. There's a new case report or case series every other month, which makes this a little bit challenging, but that's all the more reason for learning about them and for constant vigilance for patients who show up to our clinic. Dr Nevel: Yeah, absolutely. What is our current understanding of the associated pathophysiology of these conditions and the pathophysiology relating to the genetics? And then how does that relate to the treatment of these conditions? Dr Mahajan: So, a number of different disease mechanisms have been proposed. Traditionally, these were all thought to be ion channelopathies, but a number of different processes have been proposed now. So, depending on the genetic mutation that you talk about. So certain mutations can involve ion channels such as CACMA1A, ATP1A3. It can involve solute carriers, synaptic vesicle fusion, energy metabolism such as ECHS1, synthesis of neurotransmitters such as GCH1. So, there are multiple processes that may be involved. I think overall for the practicing clinician such as me, I think there is a greater need for us to understand the underlying genetics and associated phenotypes and the molecular mechanisms specifically because these can actually influence treatment decisions, right? So, you mentioned that specific genetic testing understanding of the underlying molecular mechanism can influence specific treatments. As an example, a patient presenting with proximal nocturnal dyskinesia with mutation in the ADCY5 gene may respond beautifully to caffeine. Other examples if you have SLC2A1, so gluc-1 (glucose transporter type 1) mutation, a ketogenic diet may work really well. If you have PDHA1 mutation that may respond to thiamine and so on and so forth. There are certain patients where paroxysmal movement disorders are highly disabling and you may consider deep brain stimulation. That's another reason why it may be important to understand genetic mutations because there is literature on response to DBS with certain mutations versus others. Helps like counselling for patients and families, and of course introduces time, effort, and money spent in additional testing. Dr Nevel: Other than genetic testing, what other diagnostic work up do you consider when you're evaluating patients with a suspected paroxysmal movement disorder? Are there specific things in the history or on exam that would prompt you to do certain testing to look for perhaps other things in your differential when you're first evaluating a patient? Dr Mahajan: In this article, I provide a flow chart that helps me assess these patients as well. I think overall the history taking and neurological exam outside of these paroxysms is really important. So, the clinical exam in between these episodic events, for example, for history, specific examples include, well, when do these paroxysms happen? Do they happen or are they precipitated with meals that might indicate that there's something to do with glucose metabolism? Do they follow exercise? So, a specific example is in Moyamoya disease, they can be limb shaking that follows exercise. So, which gives you a clue to what the etiology could be. Of course, family history is important, but again, talking about the exam in between episodes, you know, this is actually a great point because out– we've talked about genetics, we've talked about idiopathic paroxysmal movement disorders, –but a number of these disorders are because of acquired causes. Well, of course it's important because acquired causes such as autoimmune causes, so multiple sclerosis, ADEM, lupus, LGI1, all of these NMDAR, I mentioned Moyamoya disease and metabolic causes. Of course, you can consider FND as under-acquired as well. But all of these causes have very different treatments and they have very different prognosis. So, I think it's extremely important for us to look into the history with a fine comb and then examine these patients in between these episodes and keep our mind open about acquired causes as well. Dr Nevel: When you evaluate these patients, are you routinely ordering vascular imaging and autoimmune kind of serologies and things like that to evaluate for these other acquired causes or it does it really just depend on the clinical presentation of the patient? Dr Mahajan: It mostly depends on the clinical presentation. I mean, if the exam is let's say completely normal, there are no other risk factors in a thirty year old, then you know, with a normal exam, normal history, no other risk factors. I may not order an MRI of the brain. But if the patient is 55 or 60 (years) with vascular risk factors, then you have to be mindful that this could be a TIA. If the patient has let's say in the 30s and in between these episodes too has basically has a sequel of these paroxysms, then you may want to consider autoimmune. I think the understanding of paraneoplastic, even autoimmune disorders, is expanding as well. So, you know the pattern matters. So, if all of this is subacute started a few months ago, then I have a low threshold for ordering testing for autoimmune and paraneoplastic ideology is simply because it makes such a huge difference in terms of how you approach the treatment and the long-term prognosis. Dr Nevel: Yeah, absolutely. What do you find most challenging about the management of patients with paroxysmal movement disorders? And then also what is most rewarding? Dr Mahajan: I think the answer to both those questions is, is the same. The first thing is there's so much advancement in what we know and how we understand these disorders so regularly that it's really hard to keep on track. Even for this article, it took me a few months to write this article, and between the time and I started and when I ended, there were new papers to include new case reports, case series, right? So, these are rare disorders. So most of our understanding for these disorders comes from case reports and case series, and it's in a constant state of advancement. I think that is the most challenging part, but it's also the most interesting part as well. I think the challenging and interesting part is the heterogeneity of presentation as well. These can involve just one part of your body, your entire body can present with paroxysmal events, with multiple different phenomenologies and they might change over time. So overall, it's highly rewarding to diagnose such patients in clinic. As I said before, you can make a sizeable difference with the medication which is usually inexpensive, which is obviously a great point to mention these days in our health system. But with anti-seizure drugs, you can put the right diagnosis, you can make a huge difference. I just wanted to make a point that this is not minimizing in any way the validity or the importance of diagnosing patients with functional neurological disorders correctly. Both of them are as organic. The importance is the treatment is completely different. So, if you're diagnosing somebody with FND and they do have FND and they get cognitive behavioral therapy and they get better, that's fantastic. But if somebody has paroxysmal movement disorders and they undergo cognitive behavioral therapy and they're not doing well, that doesn't help anybody. Dr Nevel: One hundred percent. As providers, obviously we all want to help our patients and having the correct diagnosis, you know, is the first step. What is most interesting to you about paroxysmal movement disorders? Dr Mahajan: So outside of the above, there are some unanswered questions that I find very interesting. Specifically, the overlap with epilepsy is very interesting, including shared genes, the episodic nature, presence of triggers, therapeutic response to anti-seizure drugs. All of this I think deserves further study. In the clinic, you may find that epilepsy and prognosis for movement disorders may occur in the same individual or in a family. Episodic ataxia has been associated with seizures. Traditionally this dichotomy of an ictal focus. If it's cortical then it's epilepsy, if it's subcortical then it's prognosis for movement disorders. This is thought to be overly simplistic. There can be co-occurrence of seizures and paroxysmal movement disorders in the same patient and that has led to this continuum between these two that has been proposed. This is something that needs to be looked into in more detail. Our colleagues in Epilepsy may scoff this, but there's concept of basal ganglia epilepsy manifesting as paroxysmal movement disorders was proposed in the past. And there was this case report that was published out of Italy where there was ictal discharge from the supplementary sensory motor cortex with a concomitant discharge from the ipsilateral coordinate nucleus in a patient with paroxysmal kinesigenic cardioarthidosis. So again, you know, basal ganglia epilepsy, no matter what you call it, the idea is that there is a clear overlap between these two conditions. And I think that is fascinating. Dr Nevel: Really interesting stuff. Well, thank you so much for chatting with me today. Dr Mahajan: Thank you, Kait. And thank you to the Continuum for inviting me to write this article and for this chance to speak about it. I'm excited about how it turned out, and I hope readers enjoy it as well. Dr Nevel: Today again, I've been interviewing doctor Abhi Mahajan about his article on diagnosis and management of paroxysmal movement disorders, which appears in the August 2025 Continuum issue on movement disorders. I encourage all of our listeners to be sure to check out the Continuum Audio episodes from this and other issues. As always, please read the Continuum articles where you can find a lot more information than what we were able to cover in our discussion today. And thank you for our listeners for joining today. And thank you, Abhi, so much for sharing your knowledge with us today. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

في الحلقة دي هتشوفوا إزاي في ناس بيدعوا.. إنهم دكاترة ومتخصصين أو حتى رجال دين - ممكن يدمروا نفسيه بنت صغيرة طول حياتها. تخيلوا دكتور ممكن يقول لبنت وهي عندها ١٣ سنة “إنتي عارفه إنك ممكن متخلفيش في حياتك” أو رجل دين يقول “إنتي لابسك جن” أو أخصائية بتقول “اللي عندك ده بسبب إن والدتك عملت حاجه غلط في حياتها” يا رب بعد الحلقة دي نقدر قيمة الكلمة اللي بتطلع من بقنا قبل ما نقولها..ونعرف قد إيه كلمة صغيرة ممكن تدمر نفسيه أي واحد فينا. رنا فياض - بنت صغيرة .. بس بطلة. —— دايما بنسمع عن نجاح أشخاص، بس ما بنعرفش هما إزاي وصلوا! في G.Talks مع شادي شريف هنسمع قصتهم ورحلتهم و إزاي وصلوا للنجاح ده. كل قصة منهم لو نجحت إنها تساعد شخص واحد بس في حياته، يبقى إحنا كده نجحنا. تقدروا تدعمونا من خلال الاشتراك في القناة ومشاركة الحلقات. —— برعاية E& Egypt Madinet Masr من إنتاج TPP —— اسمعوا الحلقات على منصات البودكاست Apple Podcasts - https://shorturl.at/bhlpF Spotify - https://shorturl.at/hoAGJ Anghami - https://shorturl.at/gJKQW تواصلوا معانا Facebook - https://shorturl.at/FNX04 Instagram - https://shorturl.at/cmnS0 TikTok - https://shorturl.at/eiFL3 تواصلوا مع شادي شريف Instagram - https://shorturl.at/nJV45 Linkedin - https://shorturl.at/csyEQ —— 00:00 المقدمة 01:03 احكيلي قصيتك 07:59 أكتر موقف اثر فيكي؟ 10:11 دي مشكلة نفسية أكتر؟ 15:01 إيه أكتر حاجة بتضايق في نظرة الناس؟ 31:15 بتحبي إيه؟ 32:04 نفسك تعملي إيه؟ 37:54 سؤال الضيف اللي فات 38:45 سؤال الضيف اللي جاي #G.Talks #shady_sherif #epilepsy Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

Nick is STILL in control and Grunny isn't liking it! On this episode of Talk About It, we conclude this short two-part series in which Nick asks Greg questions that have come in over time from caregivers, people living with epilepsy, and even questions that Nick has for Greg. If you missed part one, we encourage you to go back and hear Greg speak candidly about his family's experience on the journey with Jake and reminding you that you are not alone and there is support for you. This episode gets more practical - discussing Jake's routines that he has established to minimize the potential for a seizure, how to talk to medical professionals when you have appointments, how to research treatements, and what is in store for the future of Talk About It! Get your notebooks out and be ready for all the invaluable information that you are about to hear! Talk About It with Greg Grunberg is excited to be sponsored by Neurelis and by Jazz Pharmaceuticals.  

In this conversation, Brigiette shares her personal journey as a mother of two children diagnosed with autism and epilepsy. She discusses the challenges of navigating the diagnosis process, the emotional impact of seizures, and the importance of advocacy and self-care. Bridget emphasizes the need for parents to trust their instincts and seek support, while also highlighting the unique experiences of raising children on the spectrum. The conversation concludes with practical advice for parents facing similar challenges, reinforcing the message that they are not alone in their journey.What we discuss:00:00 Introduction and Personal Connection to Autism and Epilepsy03:11 Navigating the Diagnosis Journey for Two Children06:09 Understanding Seizures: Experiences and Emotional Impact08:57 The Role of Advocacy in Autism and Epilepsy11:57 Self-Care and Balancing Family Responsibilities15:03 Advice for Parents Facing Epilepsy DiagnosesConnect with Brigiette:Instagram: www.instagram.com/educationhustlerFacebook: Brigiette LewisResources Mentioned:The Parents' Place of Marylandhttps://www.ppmd.org/Tune in to this episode to discover invaluable insights, heartfelt wisdom, and practical tips on navigating autism and epilepsy. FOLLOW US:Instagram: www.instagram.com/theabmpodcastFacebook: www.facebook.com/theabmpodcastYouTube: www.youtube.com/theabmpodcast

The rationale, design, and mechanism of GABA aminotransferase and ornithine aminotransferase inactivators will be presented as well as in vitro and in vivo efficacy and pharmacokinetic results, toxicology studies, and a clinical trial with one of the inactivators.

Our understanding of dementia may need an update. Annemari Kilpelainen, doctoral researcher at the University of Eastern Finland, tells us why. Annemari Kilpeläinen is a neurologist at the Neurocenter of Kuopio University Hospital and a PhD researcher at the University of Eastern Finland. Her clinical interests focus on epilepsy and movement disorders, while her research […]

A young inventor has taken home the top honours at the James Dyson Awards for a pair of glasses made to tackle epilepsy. University of Canterbury engineering student Mark Campbell has developed ‘Lensare', which uses smart LCD lenses that detect harmful light patterns and instantly darken, providing protection for people with epilepsy and photophobia. Campbell told Mike Hosking it's still in the early stages of development, but the aim is to make it as bulletproof as possible. He says the next steps are to make the prototype as robust and unobtrusive as possible, but after that there's the potential to commercialise it. LISTEN ABOVE See omnystudio.com/listener for privacy information.

This month, as the eLife Podcast hits its century, we hear how getting frog dads to cross-foster tadpoles has revealed the way in which some frogs come by their microbiomes, the ants that do gene therapy, signs that disease causes a breakdown in nutrient exchange between the elements of the microbiome, how fungi reprogram immune cells to cause over-reactions in sepsis, and new insights into how tapeworm larvae in the brain cause seizures... Get the references and the transcripts for this programme from the Naked Scientists website

Send comments and feedbackIn a retrospective study of 31 patients with highly refractory epilepsy, 29% had more than a 50% reduction in seizures for at least 12 months after being treated with immunotherapy. Three of these patients became seizure free. Other than a trend toward a diagnosis of focal epilepsy, researchers did not identify any specific features predictive of treatment response. Sharp Waves spoke with the first author about the study and its implications.The study was published in Epilepsia in April 2025. Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.Let us know how we're doing: podcast@ilae.org.The International League Against Epilepsy is the world's preeminent association of health professionals and scientists, working toward a world where no person's life is limited by epilepsy. Visit us on Facebook, Instagram, and LinkedIn.

In this episode, we dive into the world of epilepsy dyskinesia syndrome (EDS) with our guest, Dr. Darius Ebrahimi-Fakhari. Listen as he unpacks the findings from one of the largest multinational studies to date, involving over 600 patients across 25 countries. Read the article.

In this episode, Emily Kircher-Morris has a heartfelt conversation with Lake Bell, an award-winning actress, writer, and director, who opens up about her journey as a mother navigating her daughter Nova's epilepsy diagnosis. Emily and Lake talk about the challenges of living with neurodiversity, and discuss ways to turn them into victories. Lake shares the impact of seizures on Nova's identity, and she reflects on her own experiences with dyslexia. They talk about the importance of reframing neurodiversity, and the role of advocacy in destigmatizing conditions like epilepsy. TAKEAWAYS Finding the right epilepsy medication can be challenging. Epilepsy can positively impact and shape family dynamics. Unique strengths are created in challenging situations. Stigmas surrounding epilepsy are an ongoing challenge. Uniqueness is just a difference, not a weakness. Join us for our free event, Creating Neurodiversity-Affirming Schools, a learning and continuing education opportunity. The event is Tuesday, September 9th at 8pm Eastern/5pm Pacific. It will feature a presentation by Emily Kircher-Morris and Amanda Morin, and you'll hear from a panel of experts about the future of education. Register now! Lake Bell is an award-winning actress, writer, and director known for her work across film, television, and audio storytelling. She stars in HBO's upcoming series The Chair Company opposite Tim Robinson and recently received the Hollywood Critics Association Award for her directing work on the Emmy-nominated limited series Pam and Tommy. Bell is also the author and narrator of Inside Voice: My Obsession With How We Sound, an acclaimed audiobook produced by Malcolm Gladwell's Pushkin Media. Bell made her directorial debut with In a World…, which premiered at the 2013 Sundance Film Festival and earned the Waldo Salt Screenwriting Award along with widespread critical praise. Her second feature film, I Do... Until I Don't, showcased her talents as a writer, director, and lead actress. Her acting credits include roles in Mother Couch, No Escape, Man Up, It's Complicated, Home Again, and the Harley Quinn and Marvel's What If animated series. A graduate of The Rose Bruford College in London, Bell is also a dedicated advocate, serving on the board of Women in Film and as a global ambassador for Women for Women International, championing the voices of women survivors of war. BACKGROUND READING Instagram, Wikipedia, All About Brains: A Book About People The Neurodiversity Podcast is on Facebook, Instagram, BlueSky, and you're invited to join our Facebook Group.

It's a difficult week for P.J. as his family is faced with a medical emergency that had to cut this episode short. A quick but meaningful conversation transpires. Travis tells a tall tale that might just get you hooked. Great Law. Less Legal. Law Done Lite!

This episode is like no other.  In this episode of Talking Smack 415, Jamie the great and I sit down with Dawn Geller.  Dawn recently experienced every mother's worst nightmare, the sudden tragic death of her 20 year old son Dylan. This interview is raw, the pain cuts through your soul, and Dawn is beyond courageous to share her story.  We retrace the phone calls and the experience the day of Dylan's deathWe dive into grief and grief counseling We talk about the funeral and being supported by a village And we remember Dylan - the light he was in the world, how he lived with compassion, resilience, a deep commitment to helping others, and he always rooted for the underdog. He leaves behind his legacy and  continues to sprinkle his fairy dust ( as Jamie the Great says) through the Do it Like Dylan Non Profit .Do It Like Dylan was established by the siblings of Dylan Geller to honor his memory. Their mission is to advance Epilepsy research, provide scholarships for students pursuing degrees in Special Education, and advocate for critical Epilepsy safety legislation. Through these efforts, the family strives to continue Dylan's legacy of kindness, inclusion, and lasting impact.You can donate here or volunteer here . In addition through Dylan's organ donations he saved 150 lives that night. If you happen to be one of the lucky recipients of Dylan's organs please reach out.  The family would love to meet you.    It's a heartbreaking and uplifting episode, grab your tissues .May his memory be a blessing. זיכרונם לברכה / zikhronam livrakhaIf you or anyone you know has epilepsy please share this episode and make sure they are wearing a Level 1 Life Jacket in the water- it's life saving and will turn most unconscious wearers face-up in water. It's not epilepsy that kills you it's what you're doing when epilepsy strikes that kills you. Learn more about Do it Like Dylan on facebook & InstagramPS- SAVE THE DATE - The Do It Like Dylan 5k run/ family walk is Saturday, November 15th.  Location information to come.  Share this episode with your friends and family who love to laugh. Subscribe to Talking Smack 415 and leave us a rating and review so more peeps can find us for laughter and friendship to feed your soul!

The power to change lives and save lives: expert advice on how to recognize where action needs to be taken and what to do. Credit available for this activity expires: 9/2/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002731?ecd=bdc_podcast_libsyn_mscpedu

Let us know what you think! Text us!In this inspiring episode of Security Halt!, host Deny Caballero sits down with Green Beret veteran and firefighter Zachary Garner to explore his extraordinary journey of resilience, faith, and personal growth. From the battlefield to the firehouse, Zach has faced life-altering challenges—including a battle with epilepsy and a near-fatal infection—that tested his strength and determination.Through it all, Zach found healing and purpose in endurance sports, community support, and faith. His story is a testament to perseverance, overcoming adversity, and the power of sharing personal struggles to inspire others. This conversation dives deep into mental health, brotherhood, and the courage it takes to keep moving forward—no matter the obstacle.

The September 2025 Recall replay highlights four previously released episodes focused on epilepsy. Dr. Halley Alexander begins the series with Dr. Juan Luis Alcala-Zermeno, discussing outcomes of epilepsy surgery in patients with tonic-clonic seizures. She then speaks with Dr. Samuel W. Terman about patients' perceived seizure risk, seizure risk tolerance, and approaches to risk counseling. In the third episode, Dr. Alexander is joined by Dr. Vineet Punia to explore factors influencing the decision to continue or discontinue anti-seizure medications at discharge for patients hospitalized with acute symptomatic seizures. The replay concludes with Dr. Katie Krulisky's conversation with Dr. Leah Blank on how outpatient follow-up impacts readmission rates in older adults with epilepsy or seizures Podcast links:  The Effect of Epilepsy Surgery on Tonic–Clonic Seizures  Patient Perspectives on Antiseizure Medication Discontinuation  Understanding Acute Symptomatic Seizures    Outpatient Follow-Up With 30-Day Readmission After Epilepsy or Seizure Discharge  Article links:  The Effect of Epilepsy Surgery on Tonic–Clonic Seizures Patient Perspectives on Antiseizure Medication Discontinuation  Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures Association of Outpatient Follow-Up With 30-Day Readmission After Epilepsy or Seizure Discharge in Medicare Beneficiaries Aged 65 and Older   Disclosures can be found at Neurology.org. 

Nutritionist Leyla Muedin discusses the critical role of mitochondrial health throughout the lifespan, citing Dr. Jeffrey Bland's insights on mitochondria as a cornerstone of 21st-century health. The episode explores the benefits of ketosis and the ketogenic diet, particularly in supporting neurological health and conditions like epilepsy, Alzheimer's, and multiple sclerosis. Leyla highlights how ketogenic diets stimulate mitochondrial biogenesis and improve mitochondrial function while addressing potential contraindications for specific populations. The importance of a functional medicine approach and personalized interventions is emphasized for optimal health outcomes.

Take cover, everybody, Producer Nick has the reigns! Over the years, Talk About It has received so many questions from viewers ranging from how to deal with an epilepsy diagnosis, to what to do if you are a caregiver, to practical quesitons about establishing routines and how to prevent seizures. Every episode, we are all privileged to hear these incredible conversations from a range of guests and experts, but we have an expert sitting right there, every time: Greg! He has gone through what caregivers go through, he has dealt with medication and emerging treatments, he has become an expert on what to do when his son Jake has a seizure, and so has his family. In this special two-part AMA series of Talk About It, Greg will be in the guest seat answering questions in a real and candid way to provide a peek behind the curtain of his experiences and offer advice from one person in the community to another.  This is part one, and you don't want to miss it!  Talk About It with Greg Grunberg is excited to be sponsored by Neurelis and by Jazz Pharmaceuticals.

In this week's episode, Brain & Life Podcast hosts Dr. Daniel Correa and Dr. Katy Peters discuss some of their favorite articles in the most recent issue of Brain & Life Magazine. The dive into the effects of ultra-processed foods, helpful innovations like smartphone apps and specialized gyms, and the support sibling caregivers provide to their loved ones. If you would like to read these articles and more, check out the latest issue!   Brain & Life Articles Mentioned How Ultra-processed Foods Can Have a Negative Effect on Brain Health Smartphone Apps Can Help Manage Parkinson's, Migraines, Epilepsy, and More How Specialized Gyms Empower People with Neurologic Conditions Sibling Caregivers are Supporting Brothers and Sisters Through Chronic Conditions   Other Brain & Life Podcast Episodes on These Topics The Many Faces of Cerebral Palsy with Micah Fowler, Phoebe Rae Taylor, and Kelsey Cardona We Are Brave Together with Jessica Patay Cheryl Hile is Running Around the World with Multiple Sclerosis Exploring Longevity with Author Dan Buettner   We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? ·       Record a voicemail at 612-928-6206 ·       Email us at BLpodcast@brainandlife.org   Social Media:   Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body's ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Navigating Transition: Supporting Young Adults With Epilepsy Into Adult Care," Danielle Andrade, MD, MSc, adult neurologist at the University of Toronto and co-chair of the ILAE Transition Task Force, discussed the critical process of moving pediatric patients with epilepsy into adult care. She highlighted findings from the task force's global survey on transition practices, revealing major differences across regions. Andrade also shared important considerations for students with epilepsy entering college, including lifestyle management and the “perfect storm” of seizure triggers like sleep deprivation, alcohol, and medication adherence. She spoke on the vital role of reproductive health discussions, the utility of readiness questionnaires, and the challenges of coordinating multi-specialty care. Finally, Andrade underscored the importance of clear communication between pediatric and adult neurologists, as well as the need for stronger guidelines and education worldwide. Looking for more Epilepsy discussion? Check out the NeurologyLive® Epilepsy clinical focus page. Episode Breakdown: 1:00 – Global survey findings on epilepsy transition of care 2:10 – Key considerations for students with epilepsy entering college 3:50 – Ensuring continuity of care during transition into adulthood 5:45 – Neurology News Minute 7:30 – Common challenges and strategies to overcome them 9:30 – Final thoughts on back-to-school care and global survey insights The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Ianalumab Meets Primary End Points in Phase 3 NEPTUNUS Trials of Sjögren's Disease Praxis' Vormatrigine Shows Significant Ability to Reduce Seizure Incidence in Phase 2 RADIANT Study FDA Denies Approval for Friedreich Ataxia Agent Vatiquinone, Citing More Efficacy Needed Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

In this episode of the Brain and Life podcast, Dr. Daniel Correa is joined by guest co-host Dr. Proleta Datta, assistant professor and epileptologist at Oregon Health & Science University who specializes in hard‑to‑treat seizures and improving access to epilepsy care. They delve into the complex relationship between epilepsy and driving safety, discussing the latest guidelines and recommendations while highlighting the importance of personalized care for all people living with epilepsy. Tune in to learn about the legal and practical aspects of driving with epilepsy, and discover resources available to support independence and mobility for all.   Additional Resources New Position Statement: When People with Epilepsy Can Safely Drive Again Navigating Life with Epilepsy When Is It Time to Stop Driving Because of a Neurologic Condition?   Other Brain & Life Podcast Episodes on Similar Topics JenVon Cherry on Educating Communities of Color About Epilepsy Actor Cameron Boyce's Legacy and Raising Awareness About SUDEP Tiffany Kairos on Finding Her Voice in Epilepsy Advocacy   We want to hear from you! Have a question or want to hear a topic featured on the Brain & Life Podcast? Record a voicemail at 612-928-6206 Email us at BLpodcast@brainandlife.org Social Media Guests: Dr. Proleta Datta @oshunews  Hosts: Dr. Daniel Correa @neurodrcorrea; Dr. Katy Peters @KatyPetersMDPhD

Send us a textWelcome to Celebrate Creativity Episode 441 - Did Poe Have Epilepsy?As many of you know, I used to work at the Edgar Allan Poe Museum in Richmond Virginia - my favorite room in the entire museum, and one of my favorite places in the entire world, is the Virginia Poe room name for the mother of Edgar Allan Poe.  Now this building contains  an excellent collection of the writers works - original editions of everything from Hans Pfall - for obvious reasons, the museum takes stringent security measures - security concerns and actions which I don't even begin to understand - nor would I want to.  The reason that I am talking about this collection is that it was given to the museum by a Dr.  John Robertson - he not only had deep pockets, but was a neurologist - a brain doctor - and a genuine expert on the life and works of Edgar Allan Poe. He wrote a huge book about Poe's life - especially from from a neurological standpoint - and in the following episodes I would like to address some of his findings regarding America's Shakespeare - especially where Dr. John Robertson connected his medical expertise to his passion for Poe's works.  And a look at Dr. Robertson's findings are especially relevant when looking at any possible connection of Edgar Allan Poe and seizure disorders.As mentioned before, Dr. John W. Robertson's (1856-1934) was a neurologist and author who was a prominent Poe collector. His collection of Poe's works and memorabilia was substantial and is noted to have included original manuscripts and rare editions. He was a benefactor of the Poe Museum in Richmond and is also listed as having placed a plaque at a cemetery with the museum's founder, James H. Whitty. This deep interest in Poe's life and his writings went beyond simple collection; it fueled his professional endeavors.Support the showThank you for experiencing Celebrate Creativity.

The book, Racing Uphill: Confronting a Life with Epilepsy (U of Minnesota Press, 2025), is a memoir and an educational resource, which tells the story of an Emmy Award-winning TV news Journalist, Stacia Kalinoski. The author's aim is beyond giving an account of her experience of epilepsy, her goal is to sensitize readers and inspire epileptic patients and other people battling with ailments that carry social stigma, emphasizing the importance of taking control of one's health. In the book, Stacia Kalinoski recounts her experience of visual distortions and feelings of déjà vu and jamais vujamais vu, which are auras that often precede more severe seizures. She discusses the physical injuries and memory loss resulting from her condition, particularly from temporal lobe seizures. Stacia's narrative underscores the complexities of living with epilepsy and the potential for personal growth and empowerment through adversity. She highlights the effects of frequent episodes of seizure on maintenance of social relationships and the ability to reminisce about the past. Relating her experience, Stacia dwells on the importance of confronting the reality of living with epilepsy, she emphasizes the significance of understanding seizures to combat the stigma and fear surrounding the condition, and how surgery can improve memory loss and allow People Living with Epilepsy reconnect with their past.  Mariam Olugbodi is a university teacher and a writer, she is the author of the monograph titled Stylistic Features in the 2011 and 2012 Final Matches Commentaries in the UEFA Champions League, published by Grin Verlag. Mariam's greatest dream is seeing a world where knowledge is accessible to all. She does this through her volunteering roles on open knowledge platforms as a host and an editor. As part of her effort to maintain inclusion and diversity in knowledge transmission, she volunteers as a teacher in crises contexts. Learn more and connect with Mariam through her social links @ (22) Olugbodi Mariam | LinkedIn, Mariam Olugbodi (0000-0001-5027-6644) - ORCID and User:Margob28 - Meta Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

The book, Racing Uphill: Confronting a Life with Epilepsy (U of Minnesota Press, 2025), is a memoir and an educational resource, which tells the story of an Emmy Award-winning TV news Journalist, Stacia Kalinoski. The author's aim is beyond giving an account of her experience of epilepsy, her goal is to sensitize readers and inspire epileptic patients and other people battling with ailments that carry social stigma, emphasizing the importance of taking control of one's health. In the book, Stacia Kalinoski recounts her experience of visual distortions and feelings of déjà vu and jamais vujamais vu, which are auras that often precede more severe seizures. She discusses the physical injuries and memory loss resulting from her condition, particularly from temporal lobe seizures. Stacia's narrative underscores the complexities of living with epilepsy and the potential for personal growth and empowerment through adversity. She highlights the effects of frequent episodes of seizure on maintenance of social relationships and the ability to reminisce about the past. Relating her experience, Stacia dwells on the importance of confronting the reality of living with epilepsy, she emphasizes the significance of understanding seizures to combat the stigma and fear surrounding the condition, and how surgery can improve memory loss and allow People Living with Epilepsy reconnect with their past.  Mariam Olugbodi is a university teacher and a writer, she is the author of the monograph titled Stylistic Features in the 2011 and 2012 Final Matches Commentaries in the UEFA Champions League, published by Grin Verlag. Mariam's greatest dream is seeing a world where knowledge is accessible to all. She does this through her volunteering roles on open knowledge platforms as a host and an editor. As part of her effort to maintain inclusion and diversity in knowledge transmission, she volunteers as a teacher in crises contexts. Learn more and connect with Mariam through her social links @ (22) Olugbodi Mariam | LinkedIn, Mariam Olugbodi (0000-0001-5027-6644) - ORCID and User:Margob28 - Meta Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine

The book, Racing Uphill: Confronting a Life with Epilepsy (U of Minnesota Press, 2025), is a memoir and an educational resource, which tells the story of an Emmy Award-winning TV news Journalist, Stacia Kalinoski. The author's aim is beyond giving an account of her experience of epilepsy, her goal is to sensitize readers and inspire epileptic patients and other people battling with ailments that carry social stigma, emphasizing the importance of taking control of one's health. In the book, Stacia Kalinoski recounts her experience of visual distortions and feelings of déjà vu and jamais vujamais vu, which are auras that often precede more severe seizures. She discusses the physical injuries and memory loss resulting from her condition, particularly from temporal lobe seizures. Stacia's narrative underscores the complexities of living with epilepsy and the potential for personal growth and empowerment through adversity. She highlights the effects of frequent episodes of seizure on maintenance of social relationships and the ability to reminisce about the past. Relating her experience, Stacia dwells on the importance of confronting the reality of living with epilepsy, she emphasizes the significance of understanding seizures to combat the stigma and fear surrounding the condition, and how surgery can improve memory loss and allow People Living with Epilepsy reconnect with their past.  Mariam Olugbodi is a university teacher and a writer, she is the author of the monograph titled Stylistic Features in the 2011 and 2012 Final Matches Commentaries in the UEFA Champions League, published by Grin Verlag. Mariam's greatest dream is seeing a world where knowledge is accessible to all. She does this through her volunteering roles on open knowledge platforms as a host and an editor. As part of her effort to maintain inclusion and diversity in knowledge transmission, she volunteers as a teacher in crises contexts. Learn more and connect with Mariam through her social links @ (22) Olugbodi Mariam | LinkedIn, Mariam Olugbodi (0000-0001-5027-6644) - ORCID and User:Margob28 - Meta Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/biography

Tony (11, M) Story.  Now we sleep with the alarm on every night.   Elopement:  involves leaving a safe or supervised area without permission. poses a risk to the individual's safety. can occur in various settings. is a common behavior in individuals with ASD. Virginie (10, M) Stories and Service Dog.   Single Mom (9, M) heading to the judge and calls me asking for papers.  Here you go…   Let's note that Elopement was masked behind broader buckets and I think this is a miss.  We need to name and discuss this very challenging behavior.   FB Survey.  4 hours.  100+ votes, 100 comments.   https://www.facebook.com/groups/syngap/posts/1734514154096968/ 76% of respondents eloped (35% F, 41% M) 24% didn't (17% F, 7% M)   11 F, no elopement at home - but sometimes tries to elope while at school. C ( has always been an eloper - kid has a sixth sense for when someone leaves the door unlocked C elopes and age 16 years old H 9 girl constantly running away B-7.5 years old Girl - 3 Fourteen. She doesn't anymore, but used to. Not to the degree that other families struggle, but we definitely had to keep an extra close eye/ear. Had bells on all our doors, etc. Did get a call from our neighbor once while I was making dinner saying that S had just walked into her house, that she was safe, and was helping to give their baby a bath. Thankfully they were very good friends and took it in stride. (S was about four at the time.) Boys age 7. He has for awhile Boy, age 8.5. Just started eloping more so recently, in the last year. 11, girl Boy age 15 13 year old girl Girl-3 Ty 10 elopes since he can walk. It's our biggest problem. Boy age 8 but has been doing it for a while Age 7, girl. Boy - 14y/o Boy age 9… he's a track star! Boy age 12, has eloped since he could walk/run. It probably peaked around age 6 and got better with meds. Elopement is less frequent now but scarier now that he's older and higher. Boy 10. Always has wandered and will still now run off knowing he's not suppose to Any chance he gets 13 My boy (22 y/o) always was and is now a master of escape, he can hear if I turn the key in the door, front door has an alarm fitted just in case Boy , 25 the risk is high because he looks typical 25 yo female, requiring alarms, cameras,and specialized door locks.  In a state that says that these measures are unlawful restraint and invasion of privacy   Frazier, 2025. Extremely High finding as a Symptom of SYNGAP1.  See Table 2 of Quantifying neurobehavioral profiles across neurodevelopmental genetic syndromes and idiopathic neurodevelopmental disorders https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16112   McKee, 2025.  Notes the significantly heightened enrichment of Autistic Behavior and Behavioral Abnormality vs. Rett, Angelman or Epilepsy cohorts.  See Figure 2B of Clinical signatures of SYNGAP1-related disorders through data integration. https://www.gimjournal.org/article/S1098-3600(25)00066-8/abstract   Cunnanne, notes impulsivity (which is a euphemism for elopement if I have ever heard one) and has three quotes in Table 1 (see below), but also notes in Figure 2 that both ASD and lack of danger awareness came up in almost every interview.  See SYNGAP1-Related Intellectual Disability: Meaningful Clinical Outcomes and Development of a Disease Concept Model Draft.  https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5098346   Impulsivity quotes:   Runs toward streets - “He wouldn't stop himself from running into the road. He climbs things in that house that you're like‘oh my god, how are you going to get out of that?'”   Jumps into pools - “He would walk into a pond. We were at the pool the other day…and he just walked off the edge and just fell into the water and was like… he would have just drowned.”   Runs toward crowds - “She was a bolter. So that was always scary. We had a few scares where you look away for a moment, I mean, we always had somebody with her, but it could be a moment's time and it's like where'd you go, you thought she was right there.”   FUNDRAISING 3 events in 3 states… https://mailchi.mp/curesyngap1.org/3-events-1-mission-support-syngap1-families-this-fall?e=e95ed9a1c4  Gala for SYNGAP1 August 22, 2025 - Farmingdale, NJ cureSYNGAP1.org/Gala5 Beacon of Hope September 12, 2025 - Boston, MA cureSYNGAP1.org/Beacon25 Scramble for SYNGAP October 4, 2025 - Greer, SC cureSYNGAP1.org/Scramble   Also, Conference is in 107 Days https://curesyngap1.org/events/conferences/cure-syngap1-conference-2025-hosted-by-srf/   STUDIES - MATTER https://docs.google.com/presentation/d/1yRPHMRY3pXPgbOacDM9Sr906VejdJWsonUWvqRD9VVI/edit?usp=sharing    Pubmed is at 37 (One a week!) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2025-2025&timeline=expanded&sort=date&sort_order=asc   SHARE BLOOD TO THE SRF BIOBANK AT CB! Read here for more information: https://curesyngap1.org/blog/fueling-research-syngap1-combinedbrain-biorepository-roadshow/    VOLUNTEER  Join us: https://curesyngap1.org/volunteer-with-srf/    SOCIAL MATTERS - 4,283 LinkedIn.  https://www.linkedin.com/company/curesyngap1/  - 1,420 YouTube.  https://www.youtube.com/@CureSYNGAP1    - 11,303 Twitter https://twitter.com/cureSYNGAP1  - 46k Insta https://www.instagram.com/curesyngap1/    NEWLY DIAGNOSED? Next New Family Webinar - Tuesday Sept. 9th, 2025, 5 PM Pacific scheduled! https://curesyngap1.org/resources/webinars/webinar-105-syngap-research-fund-quarterly-webinar-new-syngap1-family-orientation/   Resources https://curesyngap1.org/syngap1-resources-for-newly-diagnosed-families   Podcasts, give all of these a five star review! https://cureSYNGAP1.org/SRFApple   https://podcasts.apple.com/us/channel/syngap1-podcasts-by-srf/id6464522917    Episode 178 of #Syngap10  #Advocate #PatientAdvocacy #UnmetNeed #SYNGAP1 #SynGAP #SynGAProMMiS

My guest is Dr. Sergiu Pașca, MD, professor of psychiatry and behavioral sciences at Stanford University. We discuss the biology and genetics of autism, why autism diagnoses are increasing and recent progress in using stem cells to understand and treat profound autism and other brain disorders. Dr. Pașca explains “organoids and assembloids”—human stem cell–derived tools he pioneered to study, treat and cure complex brain diseases. We also discuss ethical and safety issues with using gene editing and stem cells in humans. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Helix: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00) Sergiu Pașca (02:08) Autism Spectrum Disorder, Incidence, Genetics (07:16) Is Autism More Common in Males? (09:35) Sponsors: David & Helix Sleep (11:56) Eye Contact in Babies, Fever; Proposed Causes of Autism; Genes (18:48) Genetic or Idiopathic Autism Diagnoses, Timothy Syndrome (21:37) Rise in Autism Diagnoses (26:46) Cause, Correlation & Neurological Disease; Schizophrenia, Do Vaccines Cause Autism? (31:34) Global Increase in Autism; Gene Therapy, CRISPR, Follistatin (41:05) Sponsors: AG1 & BetterHelp (43:41) Stem Cells, Ethics, Yamanaka Factors, Human Stem Cell Models (52:03) Umbilical Stem Cells; Stem Cell Injections & Dangers, Autistic Kids (59:30) Organoids, Modeling Brain Development, Intrinsic Development Timer (1:12:22) Assembloids, Brain Cell Migration & Circuit Formation, Self-Organization (1:21:22) Four-Part Assembloid, Sensory Assembloid, Pain Conditions (1:25:45) Sponsor: Function (1:27:33) Future Medical Therapies, Cell Banking, Immortalize Tissues, Rejuvenate Cells (1:34:56) Assembloids & Ethics, Importance of Nomenclature, Science Collaboration & Self-Correction (1:45:38) Cell Transplantation & Ethics, Timing (1:55:05) Genetic Testing for Parents, Genetic Penetrance (2:02:36) Assembloids, Timothy Syndrome, Epilepsy, Schizophrenia, Dystonia (2:14:30) Scientific Career, Walking, Art, Medical School (2:20:44) Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Our guest this week is Chris Losacco of Evergreen, CO who is owner of Elemental Forge, a blacksmith & knife maker as well as the father of two young children, including a son with a very rare genetic disorder.  Chris and his wife, Evan, have married for nearly 10 years and are the proud parents of two young children: daughter Elliot (4) and son Wilder (3), who has a rare genetic disorder known as MEF2C, which commonly includes: intellectual disability and developmental delays, motor skill difficulties, limited or absent speech development, Epilepsy, and Autistic-like behavior. Chris is also owns Elemental Forge, a blacksmith and knife maker, is active with the MEF2C Family Foundation as well as the SFN Mastermind Group in Denver.We'll hear all about the insightful and authentic Losacco family story on this episode of the SFN Dad To Dad Podcast. Show Links -Phone – (847) 525-7332Email – christmastaco@duck.com Email #2 - Chris@ElementalForge.usWebiste - https://www.elementalforge.us/U.S. MEF2C Foundation - https://www.usmef2cfoundation.org/MEF2C Family Foundation – https://www.mef2cfamilyfoundation.org/  Special Fathers Network -SFN is a dad to dad mentoring program for fathers raising children with special needs. Many of the 800+ SFN Mentor Fathers, who are raising kids with special needs, have said: "I wish there was something like this when we first received our child's diagnosis. I felt so isolated.  There was no one within my family, at work, at church or within my friend group who understood or could relate to what I was going through."SFN Mentor Fathers share their experiences with younger dads closer to the beginning of their journey raising a child with the same or similar special needs. The SFN Mentor Fathers do NOT offer legal or medical advice, that is what lawyers and doctors do. They simply share their experiences and how they have made the most of challenging situations.Check out the 21CD YouTube Channel with dozens of videos on topics relevant to dads raising children with special needs - https://www.youtube.com/channel/UCzDFCvQimWNEb158ll6Q4cA/videosPlease support the SFN. Click here to donate: https://21stcenturydads.org/donate/Special Fathers Network: https://21stcenturydads.org/  SFN Mastermind Group - https://21stcenturydads.org/sfn-mastermind-group/

The Guru Returns! Welcome to the concluding episode of this two-part series with health and fitness trainer/ influencer Dylan Holvey. Dylan has a private practice in the Los Angeles area where he consults with clients about workout regiments and diet, but he has also built an impressive social media following that educates his followers about healthy living. In addition, he has a weekly podcast called The Holvey Hour that is available everywhere you get your podcasts, and you should definitely be listening to every episode. This episode gets deeper into the steps that we can all take to build habits and a lifestyle that makes positive changes. It's not about taking big swings or starting programs that are unsustainable, it's about doing one thing a day to improve your diet or exercise, and then building on that to create habits. As Dylan says, if it feels too daunting to be able to do for 30 years, then don't even bother trying it for 30 days. Move that mountain one stone at a time. They also discuss the social media swindlers that are just trying to promote their own products or diet pills, and how to identify those that you shouldn't be listening to. Follow Dylan on his instagram at @dylanholveyfitness, and be sure to download his podcast, “The Holvey Hour” Talk About It with Greg Grunberg is excited to be sponsored by Neurelis and by Jazz Pharmaceuticals.

Dr. Halley Alexander and Dr. Juan Luis Alcala-Zermeno discuss the outcomes of epilepsy surgery, specifically for patients with tonic-clonic seizures.  Show references:  https://onlinelibrary.wiley.com/doi/10.1111/epi.18243  https://onlinelibrary.wiley.com/doi/full/10.1111/epi.17452  https://directory.libsyn.com/episode/index/id/26286819 

Dr. Halley Alexander talks with Dr. Juan Luis Alcala-Zermeno about the outcomes of epilepsy surgery, specifically for patients with tonic-clonic seizures.  Read the related article in Epilepsia.  Read the additional related article in Epilepsia.  Listen to the previous podcast episode mentioned in this episode.  Disclosures can be found at Neurology.org.   

Turns out, the most dangerous thing on TV in the ‘90s wasn't violence—it was Pikachu. In December, 1997, nearly 700 kids in Japan were rushed to the hospital after watching a single episode of Pokémon. No, this isn't an urban legend—it actually happened, and it was electrifying (lol). This week, Jer walks the fellas headfirst into the wild, true story of the Pokémon seizure panic, how Pikachu literally short-circuited a nation, and why poor ol' Porygon got wrongfully canceled before being canceled was cool.We break down the science of photosensitive epilepsy, uncover how a cartoon nearly led to a nationwide media meltdown. Justice for Porygon. Blame Pikachu. You can watch this entire episode over on YouTube!Follow Sickboy on Instagram, TikTok and Discord

Wed July 30, 2025 Audience: Any family with a DEE who has a kid who has seizures, yes SYNGAP1 is a DEE and you are always my first audience.   See #S10e133 if you are curious about DEE vs other names. https://curesyngap1.org/podcasts/syngap10/what-is-this-syngap1-illness-disease-syndrome-ndd-dee-mrd5-nsid-actually-called-s10e133/   Action: If your kid has motor seizures, fill out the screener and join this amazing study. Link here: https://www.resiliencestudies.com/emerald   A motor seizure is a seizure where you can see something moving – including head drops, drops, convulsive, etc. – only excluded seizures are absence, myoclonia and infantile spasms.  You don't need to figure this out, just fill in the screener, let the doctors figure it out.   Questions: Come to live webinar tomorrow, it will not be recorded, so you have to come register here: https://curesyngap1.org/resources/webinars/webinar-111-introduction-to-praxiss-emerald-study-for-syngap1-patients/   TRIAL. Any DEE patient with 4 motor seizures a month, minimum. Age 2-65.  Adults are you listening? 24 weeks (6 months) weeks, placebo controlled but everyone will get drug at some point in the trial. 28 weeks (7 months) week OLE, with a chance for expanded access, so if it works, you can stay on. Fully decentralized, you don't have to go to a site if you don't want to. One US site open so far in Bethesda, there will be others.  Int'l sites in 2026.  US ENROLLING NOW. DRUG. Lots of science and big words in the links below, but here is what you need to know as a parent. It's a liquid, can go oral or in a g-tube. There is no ramp up, you put it in and it works.  In terms of speed, think Lorazepam not Lamotrigine. It's potent and specific, which means small volume.  Roughly 1ml for 10 kg.  This will be a rounding error in the face of a normal SynGAPian med regime. Even though this is a sodium channel drug, it should benefit all DEEs b/c, good to clarify tomorrow, all seizures end with a hyperactive sodium channel firing and that is what Relutragine focuses on.   PRAXIS. Serious people, lots of work on Epilepsy.  Connected to SYNGAP1 and DEEs, just need to move faster on SYNGAP1 ASO! CSO is Steve Petrou, works with SRF AUS and knows they are waiting. KD and AN started a company for SCN2A and it was absorbed by Praxis, they are still there and are relentless. Work on both small molecules and ASO, this is a way for them to see our team in action.   Cool links: AES 2024 Story. https://eppro01.ativ.me/web/page.php?page=session&project=AES24&id=2894147 Embold read out: https://www.neurologylive.com/view/relutrigine-shows-promise-phase-2-embold-study-scn2a-dee-scn8a-dee FDA Breakthrough. https://www.globenewswire.com/news-release/2025/07/17/3117145/0/en/Praxis-Precision-Medicines-Receives-FDA-Breakthrough-Therapy-Designation-for-Relutrigine-for-the-Treatment-of-Seizures-Associated-with-SCN2A-and-SCN8A-Developmental-and-Epileptic-E.html More links. https://delta.larvol.com/Products/?ProductId=05ccb036-a308-4249-abf6-e03b120839da   Why am I doing this? We need better meds and the way to meds is through trials. We need to jump at every trial, every time. 3. This one is decentralized, so minimum burden. If you get in now, this will be over before it's ASO trial time, so you could do both. Our Syngapians with motor seizures tend to be our most severe, we have to make sure we find out if this drug can help.  All our kids may progress to this point.   See you at the webinar, fill out the screener now: https://www.resiliencestudies.com/emerald