Medical specialty of disorders which affect any portion of the nervous system
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4 episodes with neurological surgery
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Dean's Chat hosts, Drs. Jeffrey Jensen and Johanna Richey welcome Dr. David Armstrong to the podcast. This discussion wasn't about the "Diabetic Foot" as much as it was getting to know what makes the world leader in "Diabetic Foot" click. His background and fascination with technology, intro to podiatry (he considered law) to transforming clinical opportunities at Kern Hospital and UT- San Antonio. Dr. Armstrong is Distinguished Professor of Surgery and Neurological Surgery with Tenure at the University of Southern California. Dr. Armstrong holds a Master of Science in Tissue Repair and Wound Healing from the University of Wales College of Medicine and a PhD from the University of Manchester College of Medicine, where he was appointed Visiting Professor of Medicine. He is founder and co-Director of the Southwestern Academic Limb Salvage Alliance (SALSA). Dr. Armstrong has produced more than 720 peer-reviewed research papers in dozens of scholarly medical journals as well as over 120 books or book chapters. He is founding co- Editor of the American Diabetes Association's (ADA) Clinical Care of the Diabetic Foot, now in its fourth edition. Armstrong is Director of USC's National Science Foundation (NSF) funded Center to Stream Healthcare in Place (C2SHiP) which places him at the nexus of the merger of consumer electronics, wearables, and medical devices in an effort to maximize hospital-free and activity-rich days. Dr. Armstrong was selected as one of the first six International Wound Care Ambassadors and is the recipient of numerous awards and degrees by universities and international medical organizations including the inaugural Georgetown Distinguished Award for Diabetic Limb Salvage. In 2008, he was the 25th and youngest-ever member elected to the Podiatric Medicine Hall of Fame. He was the first surgeon to be appointed University Distinguished Outreach Professor at the University of Arizona. He was also the first podiatric surgeon to be selected as President of Faculty at Keck School of Medicine of USC. Furthermore, he was the first podiatric surgeon to become a member of the Society of Vascular Surgery, and the first US podiatric surgeon named fellow of the Royal College of Surgeons, Glasgow. He is the 2010 and youngest ever recipient of both the ADA's Roger Pecoraro Award and 2023 recipient of the ISDF's Karel Bakker Award, the highest awards given in the field. Dr. Armstrong is past Chair of Scientific Sessions for the ADA's Foot Care Council, and a past member of the National Board of Directors of the American Diabetes Association. He sits on the Infectious Disease Society of America's (IDSA) Diabetic Foot Infection Advisory Committee and is the US appointed delegate to the International Working Group on the Diabetic Foot (IWGDF). Dr. Armstrong is the founder and co-chair of the International Diabetic Foot Conference (DF-Con), the largest annual international symposium on the diabetic foot in the world. He is also the Founding President of the American Limb Preservation Society (ALPS), a medical and surgical society dedicated to building interdisciplinary teams to eliminate preventable amputation in the USA and worldwide. https://limbpreservationsociety.org/ https://bakodx.com/ https://bmef.org/ www.explorepodmed.org https://podiatrist2be.com/
We explore the world of thrombectomy for acute ischemic stroke with Justin F. Fraser (@doctorjfred), MD, FAANS, FAHA, Professor and Vice-Chair of Neurological Surgery and Director of Cerebrovascular Surgery and Neuro-interventional Radiology at University of Kentucky, where he specializes in cerebrovascular, endovascular, skull base, and endoscopic transsphenoidal surgery. Learn more at the Intensive Care Academy! Find us on Patreon here! Buy … Continue reading "Episode 89: Thrombectomy for stroke, with Justin Fraser"
A panel discussion with Jim Harris, Rachel Zoeller, DPT, David W. McMillan, Ph.D., and Manesh Girn, Ph.D. Recorded live at the Aspen Psychedelic Symposium In this riveting and deeply personal conversation, moderator Jim Harris is joined by three pioneers at the intersection of neuroscience, psychedelics, and disability: Dr. Rachel Zoeller (Doctor of Physical Therapy and spinal cord injury survivor), Dr. David McMillan (Assistant Professor of Neurological Surgery at the University of Miami), and Dr. Manesh Girn (neuroscientist and postdoctoral researcher with Robin Carhart-Harris at UCSF). Together, they explore how psychedelics may do far more than treat depression or catalyze mystical experiences—they may also support healing and regeneration in the nervous system. The discussion opens with an acknowledgment that our cultural understanding of psychedelics has mostly focused on their psychological and spiritual effects. But as these experts reveal, the somatic potential of psychedelics is vast and understudied. They delve into promising areas like central and peripheral neuroplasticity, the anti-inflammatory effects of psychedelics, and how these mechanisms might play a role in healing from spinal cord injuries or paralysis. Dr. Girn breaks down the science behind psilocybin's interaction with 5-HT2A serotonin receptors, not only in the brain but also in the spinal cord. These receptors, when activated, may increase neuronal excitability and even help restore lost signaling in damaged motor pathways. He suggests that psychedelics could reopen “critical periods” for neuroplasticity—windows of opportunity for the nervous system to rewire and heal. Rachel Zoeller shares her powerful lived experience as both a physical therapist and a spinal cord injury patient. Her story brings the science to life, particularly her observation that psychedelic experiences help her reconnect to parts of her body affected by paralysis. Psychedelics, she suggests, have allowed her to rebuild mind-body communication and foster compassion toward her own physical limitations. She also underscores the need for patients to cultivate body awareness, meditation, and breathwork as essential tools for safe and effective psychedelic use. Dr. McMillan, who leads outreach at the Miami Project to Cure Paralysis, provides a clinical and safety-oriented perspective. While optimistic about the potential, he urges caution—especially with individuals who have high-level spinal cord injuries and are vulnerable to serious complications like autonomic dysreflexia. He stresses that before we can bring these treatments into clinical settings, we must carefully assess physiological risk, develop precise pharmacological protocols, and prioritize patient safety. The panel also addresses cultural and spiritual interpretations of spasticity. Drawing on both shamanic and somatic perspectives, they propose that these involuntary muscle contractions could be reinterpreted not as dysfunction, but as potential portals for healing, integration, or neurological feedback. The idea that such spasms might help the brain remap muscle groups is discussed as a provocative and hopeful reframe. The conversation wraps with a call to action: to bring together indigenous wisdom, embodied knowledge, rigorous science, and community storytelling in order to chart a new frontier in psychedelic medicine—one that does not leave the disabled community behind. As McMillan puts it, "There's a lesson to psychedelia from paralysis.” It's a reminder that neuropharmacology must consider not just molecules and mechanisms, but people and possibilities. Whether you're a clinician, researcher, patient, or curious explorer, this panel is a moving and illuminating look at how psychedelics could transform not only minds—but bodies. Thanks to Aspen Public Radio, Aspen Psychedelic Resource Center, Healing Advocacy Fund and Aspen Psychedelic Symposium for allowing us to share this podcast. A full agenda from the symposium can be found here.
The "River" stent is a novel stent designed specifically to account for the anatomical and procedural requirements of venous sinus stenosis. A multicentre study of the device's safety and efficacy is underway, comprising 39 subjects across 5 US centres. The 1-year results have been recently published in JNIS. Editor-in-Chief of JNIS, Dr. Felipe C. Albuquerque, interviews Dr. Athos Patsalides¹, author of the paper: The River study: the first prospective multicenter trial of a novel venous sinus stent for the treatment of idiopathic intracranial hypertension 1. Department of Neurological Surgery, North Shore University Hospital, Manhasset, New York, USA Please subscribe to the JNIS podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/4aZmlpT) or Spotify (https://spoti.fi/3UKhGT5). We'd love to hear your feedback on social media - @JNIS_BMJ.
Guest: Jennie Taylor, MD The FDA approval of vorasidenib marks a new era for mutant isocitrate dehydrogenase (mIDH) gliomas. Approved in 2024 for grade 2 tumors after surgery, it doubled progression-free survival in the INDIGO trial. Dr. Jennie Taylor, Associate Professor of Neurology and Neurological Surgery at the University of California San Francisco, dives into the data and explains what questions remain about long-term use and broader applications.
Guest: Jennie Taylor, MD Defined by the production of 2-hydroxyglutarate, mutant isocitrate dehydrogenase (mIDH) gliomas are diffuse, slow-growing tumors. Managing these tumors requires personalized strategies that consider resectability, histology, and long-term treatment impacts. Dr. Jennie Taylor, Assistant Professor of Neurology and Neurological Surgery at the University of California San Francisco, explains the complexities behind this type of tumor and implications for patient care. Dr. Taylor also spoke about this topic at the 2025 American Academy of Neurology Annual Meeting.
Guest: Jennie Taylor, MD Defined by the production of 2-hydroxyglutarate, mutant isocitrate dehydrogenase (mIDH) gliomas are diffuse, slow-growing tumors. Managing these tumors requires personalized strategies that consider resectability, histology, and long-term treatment impacts. Dr. Jennie Taylor, Assistant Professor of Neurology and Neurological Surgery at the University of California San Francisco, explains the complexities behind this type of tumor and implications for patient care. Dr. Taylor also spoke about this topic at the 2025 American Academy of Neurology Annual Meeting.
Guest: Jennie Taylor, MD The FDA approval of vorasidenib marks a new era for mutant isocitrate dehydrogenase (mIDH) gliomas. Approved in 2024 for grade 2 tumors after surgery, it doubled progression-free survival in the INDIGO trial. Dr. Jennie Taylor, Associate Professor of Neurology and Neurological Surgery at the University of California San Francisco, dives into the data and explains what questions remain about long-term use and broader applications.
Guest: Jennie Taylor, MD The FDA approval of vorasidenib marks a new era for mutant isocitrate dehydrogenase (mIDH) gliomas. Approved in 2024 for grade 2 tumors after surgery, it doubled progression-free survival in the INDIGO trial. Dr. Jennie Taylor, Associate Professor of Neurology and Neurological Surgery at the University of California San Francisco, dives into the data and explains what questions remain about long-term use and broader applications.
Guest: Jennie Taylor, MD Defined by the production of 2-hydroxyglutarate, mutant isocitrate dehydrogenase (mIDH) gliomas are diffuse, slow-growing tumors. Managing these tumors requires personalized strategies that consider resectability, histology, and long-term treatment impacts. Dr. Jennie Taylor, Assistant Professor of Neurology and Neurological Surgery at the University of California San Francisco, explains the complexities behind this type of tumor and implications for patient care. Dr. Taylor also spoke about this topic at the 2025 American Academy of Neurology Annual Meeting.
In this episode we speak with Dr. Jeffrey Gross about how stem cells are being used for reversing aging and to optimizing overall wellness. Dr. Gross graduated from the University of California, Berkeley with a degree in biochemistry and molecular cell biology. He earned his Doctor of Medicine in 1992 from the George Washington University School of Medicine. He contributed to virology research during his studies. After graduating, he undertook a residency in neurological surgery at the University of California, Irvine Medical Center until 1997. He then pursued a Fellowship and Chief Residency in Spinal Biomechanics at the University of New Mexico until 1999. Licensed in California and Nevada, Dr. Gross has SPINE practices in Orange County and Henderson, Nevada. A trained neurological surgeon, he specializes in athletic injuries and spine procedures and offers longevity and biohacking consultations. He achieved board certification by the American Board of Neurological Surgery and is a member of several prestigious medical societies. He has written textbooks and articles in his area of expertise and is a peer-reviewer for the state of California and a scientific journal. Since 2020, Top Doctor recognized Dr. Gross as a leading Neurological Surgeon. He also received HealthTap's 2022 Top Doctor Award as a top Neurological Surgeon in the U.S. Dr. Gross founded ReCELLebrate, focusing on anti-aging and regenerative medicine. Learning Points: • What are stem cells and exosomes? • How are stem cells being used in regenerate and longevity medicine? • How can lifestyle choices amplify the longevity effects of regenerative treatments? Social Media: https://recellebrate.com/ https://www.instagram.com/recellebrate/ https://www.tiktok.com/@recellebrate https://www.youtube.com/@stemcellwhisperer https://www.linkedin.com/in/jeffrey-gross-md-5605605/
In this episode, Dr. Julian Bailes, Chair of Neurological Surgery at Endeavor Health Neurosciences Institute, discusses groundbreaking research on diagnosing chronic traumatic encephalopathy (CTE) in living patients. He shares insights into the latest clinical trials, the future of neurosurgical care, and advice for emerging healthcare leaders.
ESPN, AP, USA Today, NFL Neurosurgeon, Ironman TriathleteIt is not everyday that I get to speak to a renowned neurosurgeon for the NFL. Yes! The National Football League. In addition, long time team neurosurgeon for the Pittsburgh SteelersMarch 4, 2022 The NFL Physicians Society (NFLPS) awarded the Arthur C. Rettig Award for Academic Excellence to Joseph C. Maroon, MD. Dr. Maroon is a neurosurgeon for the Pittsburgh Steelers for 38 years and recently presented at the NFLPS scientific meeting during the 2022 NFL Scouting Combine. Dr. Maroon is the first Neurosurgeon to receive this award.Joseph C. Maroon, M.D., FACS, is Professor and Vice chairman of the Department of Neurological Surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center. He is a world-renowned neurosurgeon, health and nutrition expert and Ironman triathlete. He obtained his medical and neurosurgical training at Indiana University, Georgetown University, Oxford University in England and the University of Vermont. He is regarded as a premiere specialist in the surgical treatment of injuries and diseases of the brain and spine, particularly with microscopic and minimally invasive procedures. He had done extensive research into brain tumors, concussions and diseases of the spine that have led to many innovative techniques for diagnosing and treating these disorders. Consistently listed in America's Best Doctors, he has an international referral baseTeam neurosurgeon for the Pittsburgh Steelers since 1981, Dr. Maroon has successfully performed surgery on numerous professional football players and other elite athletes with potentially career-ending neck and spine injuries, safely returning them all to their high level of athletic performance. He serves on the National Football League's Mild Traumatic Brain Injury Committee. Along with Mark Lovell, Ph.D., in the early 1990's, Dr. Maroon co-developed ImPACT™ (Immediate Post-Concussion Assessment and Cognitive Testing), the first, most-widely used and most scientifically validated computerized concussion evaluation system. ImPACT is a 20-minute test that has become a world-wide standard tool used in comprehensive clinical management of sports-related concussions for athletes of all ages. Over 3 million athletes have been base-lined with ImPACT™.Dr. Maroon is frequently quoted as an expert source by national media, recently including the New York Times, USA Today, Associated Press, ESPN, Sports Illustrated.© 2025 Building Abundant Success!!2025 All Rights Reserved Join Me on ~ iHeart Radio @ https://tinyurl.com/iHeartBASSpot Me on Spotify: https://tinyurl.com/yxuy23baAmazon ~ https://tinyurl.com/AmzBASAudacy: https://tinyurl.com/BASAud
Send us a textDr. Thomas Chen, MD, Ph.D. is Founder, CEO & CSO, and Board Director, of NeOnc Technologies ( https://neonc.com/ ), a developer of a proprietary, patented platform technology that can potentially transport pharma-based therapeutics directly to the brain without the normal boundary restrictions imposed by the body's Blood-Brain Barrier (BBB), providing patients with potentially more effective treatments.NeOnc is developing a portfolio of treatments for brain cancer and other central nervous system (CNS) disorders. Dr. Chen is a board-certified neurosurgeon and the Director of Surgical Neuro-Oncology at USC where he is also a tenured Professor of Neurosurgery and Pathology ( https://keck.usc.edu/faculty-search/thomas-c-chen/ ). Dr. Chen graduated summa cum laude from the University of Illinois at Urbana-Champaign, where he also received Bronze Tablet honors and was inducted into the Phi Beta Kappa national academic honor society. He attended the University of California, San Francisco, where he obtained his MD, and was inducted into the Alpha Omega Alpha National Medical Honor Society. He underwent neurosurgery training at USC and obtained a Ph.D. degree in pathobiology where his thesis was on the role of immunotherapy in malignant brain tumors. Dr. Chen is also a fellowship-trained spine surgeon and one of a few surgical neuro-oncologists in the country specializing in spine cancer surgery. He maintains a busy clinical practice in both surgical neuro-oncology and spine surgery and heads a research laboratory focused on glioma biology. Dr. Chen has published extensively on glioma biology and neurosurgery. He is on the editorial board for The Spine Journal and on the review board for Neurosurgery and Journal of Neurosurgery. He also serves on numerous national neurosurgery committees.#NeOnc #ThomasChen #NeurologicalSurgery #Neurosurgery #BrainTumor #Glioblastoma #Glioma #BloodBrainBarrier #NeuroOncology #Temozolomide #PerillylAlcohol #Meningioma #Neurology #CNS #SpinalCordInjury #BrainMetastases #Alzheimers #ParkinsonsDisease #Neuropathology #MedicalOncology #Chemotherapy #RadiationOncology #USC #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
Title: Motion Preservation vs. Fusion Guest Faculty: Michael Steinmetz, MD Hosts: Brian Gantwerker, MD and Christopher Newman, MD In this CNS Controversies podcast, we discuss the options of motion preservation surgery. We engage with Dr. Michael Steinmetz, Professor and endowed Chairman of the Department of Neurological Surgery at the Cleveland Clinic Foundation, about his experiences and thoughts on fusion alternatives.
On today's episode of The Wholesome Fertility Podcast, I speak to Dr. Jeff Gross, a top Neurosurgeon who has a background specializing in athletic injuries and spine procedures. Dr. Jeff shares his journey from spinal neurosurgery to the forefront of regenerative medicine, focusing on the transformative potential of stem cells and exosomes. He explains the science behind stem cells, their applications in treating joint degeneration, and their role in anti-aging and fertility. Dr. Jeff also discusses the regulatory landscape, the cost of treatments, and the exciting future of stem cell research, including innovative approaches to enhance mitochondrial function which has a lot of promise when it comes to egg and sperm health. Takeaways Stem cells can be used to treat various conditions, including inflammation. Accumulation of inflammation is a key factor in aging and conception challenges. Exosomes may play a significant role in the benefits of stem cell therapy. Regenerative medicine is evolving rapidly, with new research emerging. The cost of stem cell treatments can vary but is becoming more accessible. Stem cells are sourced from well-regulated donor programs in the US. Direct injection of stem cells may yield higher doses than IV administration. Future research may explore the use of exosomes in fertility treatments. Dr. Jeff emphasizes the importance of personalized treatment plans. Guest Bio: Dr. Jeffrey Gross graduated from the University of California, Berkeley with a degree in biochemistry and molecular cell biology. He earned his Doctor of Medicine in 1992 from the George Washington University School of Medicine. He contributed to virology research during his studies. After graduating, he undertook a residency in neurological surgery at the University of California, Irvine Medical Center until 1997. He then pursued a Fellowship and Chief Residency in Spinal Biomechanics at the University of New Mexico until 1999. Licensed in California and Nevada, Dr. Gross has SPINE practices in Orange County and Henderson, Nevada. A trained neurological surgeon, he specializes in athletic injuries and spine procedures, and offers longevity and biohacking consultations. He achieved board certification by the American Board of Neurological Surgery and is a member of several prestigious medical societies. He has written textbooks and articles in his area of expertise and is a peer-reviewer for the state of California and a scientific journal. Since 2020, Top Doctor recognized Dr. Gross as a leading Neurological Surgeon. He also received HealthTap's 2022 Top Doctor Award as a top Neurological Surgeon in the U.S. Dr. Gross founded ReCELLebrate, focusing on anti-aging and regenerative medicine. The mission for ReCELLebrate emphasizes offering modern biochemical treatments and considering surgery as a last resort. Websites: https://recellebrate.com/ https://www.instagram.com/recellebrate/ https://www.tiktok.com/@recellebrate https://www.youtube.com/@stemcellwhisperer https://www.linkedin.com/in/jeffrey-gross-md-5605605/ For more information about Michelle, visit: www.michelleoravitz.com The Wholesome FertilityFacebook group is where you can find free resources and support: https://www.facebook.com/groups/2149554308396504/ Check out Michelle's Latest Book: The Way of Fertility! https://www.michelleoravitz.com/thewayoffertility Instagram: @thewholesomelotusfertility Facebook: https://www.facebook.com/thewholesomelotus/ Transcript: Michelle (00:00) Welcome to the podcast, Dr. Jeff. Dr. Jeff (00:03) Thank you so much for having me. Nice to see you. Michelle (00:06) Nice to see you as well. So you definitely have a very long, impressive background. So I'd love for you to share your story on how you got to really to the anti-aging stem cells work that you do, So I'd love to just get a quick background so the listeners can hear. Dr. Jeff (00:26) Sure, thank you for that. It was by accident of sorts, maybe directed accident because I was practicing as a spinal neurosurgeon, taking care mainly of neck and back trouble, some other neurological issues, nerve problems, things like that. But my practice was highly consultative, a lot of opinions, second opinions. I was seeing patients who had neck and back problems that were perhaps... mistreated or not fully treated elsewhere. And I was kind of, I was kind of a catchall for that. But my patients came to me one at a time. And these are patients that had tried different things and they just didn't work adequately. Like physical therapy, like anti-inflammatories, like rest, like, you know, chiropractic, acupuncture, maybe spinal epidural injections or things like that. And they'd come in and say, well, you know, help for a minute, but just wasn't enough. I'm still having a lot of trouble with my neck or back or pinch nerve or whatever. And I say, well, the next thing on the menu is to talk about surgical options. And they'd say, well, I'm not that bad. So wait a minute. Okay, good. Cause I was hoping you would say you're not ready for that. Cause I really didn't want to offer that to you. Cause I've always been on the slow to operate side of things. So, a lot of them would say, well, how about lasers or how about. Michelle (01:37) Mm-hmm, yeah. Dr. Jeff (01:52) herbs or how about cannabis or how about stem cells? And I heard the stem cell one more than once and chance favors the prepared mind. So my undergraduate background is in molecular cell biology, which is kind of the stem cell, know, root of stem cell biology. And, you know, when you get whisked off from undergraduate to med school and residency and practice, you don't really get to apply that cool science. So the nerd part of me took over and said, I wonder what's happened in all these years since I went to undergraduate, you know? So instead of going to the Stodgy Neurosurgeon Convention every year, or more than one, where the same people pat themselves on the back for saying the same things for decades, I decided I'm going to open my mind and start going to stem cell and regenerative medicine meetings. Michelle (02:46) Mm-hmm. Dr. Jeff (02:46) So I can offer this to my spine patients. So I did that and I not only brought back a new tool to offer them, but it blossomed into so much more. You can't get access to regenerative medicine, stem cell medicine, and I'm using those phrases sort of interchangeably here, and not say, I'll help your knee or your ankle or your shoulder or your... autoimmune issues or other hyper inflamed states. Or, you you read more and you see accumulation of inflammation is really the aging process. And if you can fight against inflammation accumulating, you're fighting against aging. So the whole anti-aging umbrella opened up and here I am, you know, six years later where spinal medicine is only a small percentage of my practice and I love it. Michelle (03:33) Mm-hmm. Yeah. That's great. So, so for people listening, some people might be like, okay, I kind of heard about stem cells, but what exactly are they? So just for people listening for the first time, we're really not understanding that aspect of like what they are. Cause we hear about it a lot. And over the years, like you said, stem cell research has really drastically changed and has gone into so many different things. Sometimes we hear about like Dr. Jeff (03:45) So. Yeah. Michelle (04:12) you know, back in the day about them growing a liver, like, you know, the possibility of growing organs through stem cells. for people who are really new to this, I would love for you to break it down. Dr. Jeff (04:15) Yeah. Yeah. Yeah. sure, let's do stem cell 101. That's great. and being a fertility podcast, this is relevant probably more than any other area of medicine because fertility and creating an embryo is, you know, creating a group of stem cells that divide and grow into a fetus who's made of all stem cells, right? And then, Michelle (04:28) Hahaha Right. Dr. Jeff (04:54) then that fetus is born and it's a baby and the baby grows for 18, 20, 25 years, whatever. And that growth requires stem cells. And then after that, an adult has to maintain, has to replace, has to restore, has to regenerate and that requires stem cells. So what are these? They are cells from which other cells arise, from which other cells stem from. Okay? So, and they are... Michelle (05:20) Mm. Dr. Jeff (05:24) They are powerful because there are different types, right? We throw out the phrase stem cells, but when you're a one cell or a two cell or a four cell embryo, you have these omnipotent cells. They can form any part of your body. They are amazingly powerful. As those divide and differentiate, meaning take on some specific characteristics, they become less powerful and more directed, and those are called pluripotent. And a pluripotent might be able to regrow a limb. And as you, as you, and many of your listeners probably know, there are certain species that can still do that. Like a starfish, you cut off a leg of a starfish, it can regrow it. Or a tail of a lizard or a limb of an axolotl, which is a strain iguana like creature from Mexico. So there are many examples in biology where these pluripotent stem cells can be called upon. And you mentioned maybe regrowing a liver someday. that will probably require some knowledge of pluripotent stem cells, which are being looked at. However, after these stem cells sort of retain, we bank them in our body as adults, those are called multipotent. So they can't regrow a limb, they can't regrow an organ per se, although they can replace some organ cells and regenerate. And you were always replacing cells, we're replacing skin cells and you know, hair follicles and all kinds of things that require stem cells. If you have an injury and you cut yourself, you, require stem cells to help come repair that. and you know, we make new blood cells all the time that requires stem cells in our bone marrow. So we are using our stem cells. This is not new. We just know more about it now. And the whole move in regenerative medicine is, is to take Michelle (07:03) Mm. Dr. Jeff (07:19) a lesson from that biology and use it strategically to help somebody do something they need. Michelle (07:27) So interesting. So give us a couple of examples on how it works in the body. Like for somebody who needs it, for example, whereas like a therapy. Dr. Jeff (07:34) Well, the- Right. So the low hanging fruit as an example, are joint degeneration. Also called arthritis or osteoarthritis vaguely, or some people it's called bone on bone if it's bad enough. Right. And these are your painful joints. It could be from an old injury, an old arthroscopic surgery. It could be from just, you know, accumulated wear and tear. And this is a problem with the joints where the cartilage is, you know, down and the joint is painful. You can't use it as well stiffness, et cetera. And it slows people down. And when you slow people down, particularly in their older years, they're less mobile and then they can't maintain their bones, their bone density, AKA, you know, the one way to fight osteoporosis is weight bearing exercise. So if you can't, if your joints hurt, you're not going to do it. And muscle mass, cause both bone density and muscle mass are correlated with longevity. So if you keep moving. You maintain your muscles and bones, you'll live longer statistically. So in any event, we want to preserve joints. And that's kind of why I got into this field. I'm a structural guy of the spine and it easily extrapolates to the other joints. And most of the research, the well-published research comes from knees and other joints. And just parenthetically, most of the good published research that we follow, because we're not just shooting from the hip here. We do shoot some hips, but it comes from Asia and Europe. The United States is behind, although we can do these things. And, you know, we can talk about that later, but the short of it is we have a really good track record of helping people with degenerated joints in reducing pain and improving function. And we do have some examples with where we've done some MRIs. Michelle (09:09) Ha ha ha! Dr. Jeff (09:37) before and after and the after MRIs have shown some regrowth of like knee cartilage, for example, and things like that. you know, we're not allowed to make any claims because we're not yet approved for marketing claims, but I can show examples and I have to say like you invest in stocks, know, past performance does not guarantee future results or something like that, but in medicine, never, yeah, yeah. Michelle (10:01) Right, and each person is different and unique. Yeah. Dr. Jeff (10:05) But anyway, it's better, listen, if you want to try to avoid a joint replacement surgery, it's worth looking into. So whether it's spine or joints, so that's the easy stuff. Low hanging fruit, I call it. The other stuff is anything with an inflammatory problem in your body can potentially have benefits from regenerative medicine on its face being a natural anti-inflammatory. So for example, autoimmune problems with hyperinflammation. You know, like rheumatoid arthritis, thyroiditis, inflammatory bowel syndromes, MS, things that have an inflammatory component. Also, most diseases of aging are diseases of inflammation. So coronary artery disease, Alzheimer's, things like this, all have an inflammatory component. And this allows me to overlap into your area is there are some causes of fertility. issues that have an inflammatory component, whether it's a uterine issue or ovarian failure. And sometimes fighting that inflammation, whether it's through lifestyle changes, diet, exercise, mindfulness, sleep, reducing mental stress, all those things can help reduce the inflammation and help potentially lead to successful pregnancy. The same can go for use of regenerative biologics like stem cells, and they're not the only thing we use. And there are wonderful publications. And before we got on this, I refreshed my knowledge by doing a little homework. And there are even newer publications on use of these things to improve fertility. Now, most of these are from China because they are way ahead of us. But that doesn't mean they can't be applied here outside of China. Michelle (12:01) Interesting. So interesting. So how do they get these stem cells? Dr. Jeff (12:07) So stem cells and other related biologic material in the US comes from a well-regulated donor program. Typically the donors are women who are planning to have a C-section. Some of the labs even recruit the donors in the first trimester, make sure they're having a healthy pregnancy, they're not using substances they shouldn't be using, they take their prenatal vitamins, they're not in any high-risk behaviors. And at the time of the C-section, they simply, and once the mother is congratulated with her new baby, they take the amniotic fluid, they take the umbilical cord, they take the placenta and they put them on ice in a sterile fashion and they go to an FDA compliant certified lab that can test and screen the materials, make sure there's nothing in there, no diseases, no problems, and then make it available to clinics and end users like myself. So there are myths that all kinds of crazy stuff are happening out there, but not here in the US. We use highly regulated donor processes. Michelle (13:19) When you have the stem cells from donors, can they be multiplied or is it just like a finite amount? Whatever is there is there. Dr. Jeff (13:28) They can be, there are labs that put them in culture, would let them grow and divide and that's one thing that can be done. Now, just like anything, a copy of a copy of a copy tends to lose its vitality. So, things like telomere length, which is an aging marker, that changes with each division of a cell. So I don't like to use a divided material. Michelle (13:50) Mm-hmm. Dr. Jeff (13:58) I use just fresh first pass stuff. Maybe your listeners are a little young for this, but there's a really funny movie called Multiplicity, where Michael Keaton clones himself, and each clone is a little bit wonkier than the original. if you want a good laugh, yeah, check out that movie. But in short, I prefer the actual native original self. Michelle (14:15) Comedy used to be so much better. Right. Got it. Is this similar to cord blood, you know, when they, when the baby's born and they say, do you, you know, you can opt to do that and then store Dr. Jeff (14:27) When we do self, Yeah, let's tap into that for just a second and unpack it if it's okay. know, historically you would be offered to donate or not donate, but store your umbilical cord. And the purpose of that was, God forbid your child gets leukemia in seven years, you have a matched set of cells that they culture, they do divide. Michelle (15:01) Mm-hmm. Right. Dr. Jeff (15:02) and replace the child's bone marrow, you don't have to worry about a donor or a match. Now you can do that and you can also use, in some labs we'll use those umbilical cord cells as a source for any other future purpose, whether it's a joint problem or what have you, they're now doing that. In fact, you can use that for family members as well. So the reasons for a bank in your umbilical cord, and they probably won't tell you in the pamphlet, because it's not yet approved for marketing claims. Michelle (15:19) Mm-hmm. Mm-hmm. Dr. Jeff (15:31) is much more than just, you know, just in case there's a case of leukemia, you need a full bone marrow replacement. Michelle (15:39) So interesting. how, when you do have the stem cells, first of all, it must cost a fortune, it sounds like, it's limited. It's not something that you, because you're depending on donors. Dr. Jeff (15:52) No, well, there's a little bit more to it. And that, and I keep using the phrase stem cells and other biologics. Let's, let's talk about other biologics for a minute because some of these other biologics are less expensive and here in the U S it's, it's affordable. You don't have to necessarily leave the country and go to go to central America or, you know, Hong Kong to get this or Europe. A lot of the professional athletes historically went to Europe, but they're, they're getting it here, here in the U S too. Michelle (15:59) Okay. Mm-hmm. that's good. Dr. Jeff (16:22) But we found out that if we gave you stem cells, let's say you came over and I hooked up an IV and we gave you stem cells, in 10 to 14 days, those would be out of your system. However, the benefits would go on for weeks or months or even some of the benefits would be prolonged. So why is that? If the stem cells are gone, what's going on? Well, it turns out the stem cells aren't really doing all the work. The stem cells are delivering cell to cell communicating and influential Michelle (16:31) Mm-hmm. Dr. Jeff (16:52) biomolecules, peptides, growth factors, small RNAs from cell, from the stem cells to your cells, reinvigorating and activating your cells to do that work. And those, those communication packets are called extracellular vesicles or for short exosomes. And you may have seen this, a lot of estheticians use them. You know, they can do the atom to your microneedle facial. Michelle (17:11) Mm-hmm. Mm-hmm. Mm-hmm. Dr. Jeff (17:20) It's sort of an advanced vampire facial with these exosomes. So the exosomes are probably doing most of the work that the stem cells were doing. And there are advantages. They penetrate tissue better. They're easier to store and handle. They'll cross the blood brain barrier if you want them in your brain and nervous system. And they're less than half the price of stem cells. So we can do things that used to cost, you know, 20, $30,000 out of this country. for less than half of that here, because the big cost is the materials, these biologics. So what does it cost was your original question, but now that you know we're using these exosomes preferentially in a lot of these cases. And by the way, as an aside, all stem cells, sorry, start over, all cells make exosomes. We're using stem cell derived exosomes from amniotic fluid, which is quite abundant. So there are really no cells in this. Michelle (18:11) Mm-hmm. Mm-hmm. Dr. Jeff (18:19) There's no matching that needs to be done. and it's, it's wonderful. So, the, you know, for example, treating a knee, if we're trying to repair a knee, help someone heal a knee, we're asking their cells to do the work. We're just providing the, the, the re-instruction to tap back into the original factory that made that joint in the first place. And something that like that is kind of two doses of biologics, one above one below the knee. the injection, the facility and everything where we do it as sterile. All that is, you know, in the nine to 12,000, depending on what we're doing. So it's not, it's not crazy. And IVs, if we do an IV, that's anywhere from like 4,000 to 8,500, depending on the dose. Michelle (18:54) Mm-hmm. And how many times would somebody have to do that? Dr. Jeff (19:07) Maybe once. Usually the joints are one and done and then they go back to their normal wear and tear. So is it possible someone's going to come back in in 20 years and need it again maybe, but that's okay. We follow a French protocol that has published 15 year follow-up and we follow that protocol how they do it. And they've had over 82 % of the patients had wonderful results at the 15 year mark. We're waiting for them to publish the 20 year mark. Michelle (19:10) Mm-hmm. Mm-hmm. Dr. Jeff (19:35) So we're not making this up. We're just duplicating what's already been done and good science that's out there. Michelle (19:42) And for inflammatory conditions, autoimmune conditions, or even fertility, well, you know, because it's secondary to that a lot of times. Do you use IV? So really get it right into the bloodstream. Okay. Dr. Jeff (19:51) Right, right. Yeah, I would definitely. yeah. Yeah. And that's how we approach anti-aging anyway. People are biohackers, anti-agers that come in. This is what we do. And we, we do an IV. We, we try to figure out a dose that makes sense for that person based on the budget and their age and maybe their inflammatory markers and their blood tests and other things. And then we see how long it lasts. And some people get a year, two years. Some people get, you know, six months. Some people come in preventively and do every three months a lower dose. just, we customize it for the individual. Michelle (20:33) And that crosses the blood brain barrier. So it's good for brain health, really for just everything. The system. Dr. Jeff (20:37) Yeah. Anywhere there's an inflammatory burden, we'll do it. But exosomes do cross the blood-brain barrier. And let me go off script here for a second. For listeners that have been pregnant before, in later trimesters, a pregnant woman has glowing skin and her hair is growing wonderfully. And typically, there's not a lot of joint pain, maybe Michelle (20:43) Mm-hmm. Dr. Jeff (21:06) low back pain from carrying the weight, why is that woman in, you know, not having this great skin and all that, it's because that woman is getting a daily dose of stem cell derived exosomes because they also not only cross the blood brain barrier, they cross the placental barrier. So what we do is almost simulate that in a single dose. Michelle (21:25) Mm-hmm. Got it. That's so interesting. in that case, when you are doing IV, is that also one and done? Dr. Jeff (21:37) No, like I was saying, it depends on what benefits someone gets and for how long they last. It could be depending on the person's need. Now, if it's someone who's got an inflammatory problem and they're just trying to get pregnant, could be a one and done. If it's someone that has benefited from it and wants to do it repetitively, then we would help support that and make it available. Michelle (21:43) I see. Mm-hmm. Done. Have you heard of this being used and injected directly into like uterus or those areas or is it typically more like IV? Dr. Jeff (22:11) So not into the uterus, although there are examples in men of injecting the testes where they're not producing adequate sperm counts. I think IV would be a first. So I didn't read anything about ovarian injection yet. Could that be coming? Possibly. IV is obviously an easier thing to do. So I would try the IV first. But you're right, you're going to get a higher dose if you inject directly. Michelle (22:20) Mm-hmm. Or ovaries maybe? Mm-hmm. Dr. Jeff (22:40) That might be something to look at. haven't done it. We do have some sexual health shots we do at the exosomes now where we do P shots and O shots for men and women respectively for improvement in sensation, lubrication, that kind of. Michelle (22:53) Mm-hmm. I know that they do PRP with the ovaries and I think also uterus. So that's why I was asking because it's kind of similar, you doesn't have the same exact substance, but it's the idea of stimulating. Dr. Jeff (23:14) No, I completely agree with that. PRP is basically a very lower, it's the lowest end self-donated regenerative medicine. And it probably contains some cells and some exosomes in there. Michelle (23:21) Mm-hmm. Right. So interesting. that's really fascinating. for you specifically, like if people wanted to work with you, do they have to come visit you, your office, where you are? Dr. Jeff (23:38) Not necessarily. So, you know, most of what we do, we start out remotely. The vast majority of my patients come from somewhere other than Las Vegas, where I'm located, actually Henderson, Nevada, which is a suburb of Las Vegas. Most people start remotely. We do a lot of the blood tests or if they need MRIs or what have you remotely, and we only invite them to come to town if there's a reason to come to town. We do have some other colleagues in other parts of the states too that can do IVs. things like that so we can sometimes refer. Yeah. Michelle (24:09) Mm-hmm. It's really fascinating. It seems like state of the art. It's like the new thing that's coming out. Dr. Jeff (24:13) and It's a, and there are things coming. if you'll allow me to just jump there for a second. you know, we are working on some projects here at, at my practice. one of them involves exosomes that are stuffed with extra mitochondria. And for those of you that don't know, that's a small part within the cell. It's kind of a cell within the cell. we learned in high school biology, it was the powerhouse of the cell. made the energy, but it actually does much more. Michelle (24:22) of course. Yeah. Hmm Dr. Jeff (24:46) And some causes of infertility relate to poor mitochondrial activity in the cells of the ovaries and things like that. So we're looking at exosomes that could be overstuffed with, that can donate more mitochondria. So that could be very useful. There are many other reasons to do that as well. And then we're even involved in a project that may be useful to help patients with cancer. And this is a particular exosome. that comes from a certain type of immune cell, a T cell in our body, whose job is to identify, circulate around the body, identify, and then selectively remove or kill an abnormal cell like a cancer cell. So imagine that as an augmentative therapy or even as a preventative. Yeah, so we're hot on that trail. That's coming soon to a, to a re-celebrate clinic near you. Michelle (25:36) That's fantastic. I love that. That's awesome. That's really amazing. And what have you seen so far in regards to fertility? you seen people do this treatment and it work? with fertility, there's so many different reasons for why. I mean, it could be so many different. It's really a range of underlying conditions, but what have you noticed so far? Dr. Jeff (26:03) Correct. So honestly, I don't have a fertility practice that's pretty far afield from what I do. I do a lot of structural work, a lot of joints, a lot of spine. We do some autoimmune and a few other things. But I have talked to colleagues, fertility specialists in the past, and we've talked about exosomes. I was at a biohacking conference in Texas last year. Michelle (26:11) Yeah. Dr. Jeff (26:32) the Dave Asprey event and someone came up to me and asked me about fertility. So I know it's on my radar. It's just not something we put out there necessarily. had one gentleman that had low sperm count. We had talked about doing something for him, but he didn't do it yet. Michelle (26:34) Mm-hmm. But have you seen or through colleagues or any studies that have shown even just IV, doing this with IV that it's helped? Dr. Jeff (27:00) I've only read the abstract of some of the Chinese studies because we don't always get the full article translated. But most of those studies speak to direct injection. They have a lot of animal studies. So I don't have information on the clinical use of... Michelle (27:07) Okay. Dr. Jeff (27:25) exosomes personally for fertility, but I know that others have talked to me about it. So it's being done. And I, I did look it up online before we met today and you can actually find, there was a clinic in Europe that was advertising it for this purpose for fertility. Yeah. Michelle (27:31) Mm-hmm. Interesting. Yeah, which I'm sure people don't really have to go all the way to Europe. I'm sure also if you get the IV and your body's going through this anti-aging and your mitochondria are benefiting and also, which is very much linked to aging eggs. So you want to like revitalize and reawaken and also lower inflammation that also helps with egg quality and sperm quality. Dr. Jeff (27:54) and Michelle (28:08) So this is just definitely something that I found when I saw you, I was like, this is really interesting. I think that it's something that people should be hearing about. And I'm sure I wouldn't be surprised if in the future, a lot of fertility clinics are going to start looking into this as well. Dr. Jeff (28:26) Yeah, no, the one that was advertising is an international fertility group, I think, in Eastern Europe. And they specifically have a webpage on this. Now, we can't have those webpages here in the US because we are not yet approved for marketing claims. Michelle (28:32) Mm-hmm. Mm-hmm. Right. It's so interesting how all that works. But yeah, this is great. This is a really interesting topic and really great information. I love like cutting edge stuff. I love that it's kind of like to be continued because you're still like, You already have learned so much, but of course, there's so much more coming, which is exciting. I find it really exciting. Dr. Jeff (29:00) Yeah. I do too. have this renewed interest. know, I'm, I'm a self admitted nerd. So this is, gets me back into things that are very exciting. I don't get to do the same thing day after day anymore. that's, that's. Michelle (29:19) I love that. Yeah, for sure. So awesome. So for people who want to learn more about you and what you do, how can they find you? Dr. Jeff (29:30) Check out Re-Celebrate because you're celebrating the renewal of your cells. That's spelled R-E-C-E-L-L-E-B-R-A-T-E. And that is our website is recelebrate.com. Instagram is recelebrate at recelebrate it. LinkedIn, Pinterest, YouTube, but just type in recelebrate, you'll find it. Michelle (29:52) Awesome. And you'll find it also in the episode notes. So I'll share all the links in there, as well as information about Dr. Jeff. So this is a great conversation. This is really, really great. And I appreciate you coming on and explaining it so nicely and really breaking it down for us, you know, people that don't have that background. So thank you so much for coming on today, Dr. Jeff. Dr. Jeff (30:03) Yeah. you It's been my pleasure, thank you for having me.
Inside the NFL's Concussion Protocols: Dr. Allen Sills on Player Safety This week, we're thrilled to welcome Dr. Allen Sills, Chief Medical Officer of the NFL, to the Science for Sport Podcast. In a game renowned for its intensity, how does the league ensure player safety on and off the field? Dr. Sills pulls back the curtain on cutting-edge concussion protocols, game-changing safety innovations, and the evolution of health measures that protect athletes at every level. From independent spotters stopping the game to the millions invested in research and equipment, discover the science and strategy reshaping one of the world's most physically demanding sports. Dr. Sills also shares exclusive insights on the future of player safety, collaboration with global sports leagues, and how the NFL is setting new standards for health in elite sports. Whether you're an NFL fan, a sports scientist, or someone fascinated by the intersection of medicine and performance, this episode is packed with revelations you can't miss. Tune in now and join the conversation about the evolving science of saving lives in sport. About Dr Allen Sills Dr. Allen Sills is the NFL's Chief Medical Officer, appointed in March 2017 as the league's first CMO. A neurosurgeon specializing in athlete care, he is also a Professor of Neurological Surgery and Co-Director of the Vanderbilt Sports Concussion Center. Dr. Sills collaborates with team medical staffs, the NFL Players Association, and medical experts to enhance player health and safety through rule changes, equipment evolution, and injury reduction plans. He led the NFL's COVID-19 response and spearheaded the league's Injury Reduction Plan, achieving a 24% decrease in reported concussions in 2018. An active researcher with over 170 scientific publications, Dr. Sills is a member of the Concussion in Sport Group, setting international concussion standards. FREE 7d SCIENCE FOR SPORT ACADEMY TRIAL SIGN UP NOW: https://bit.ly/SFSepisode241 Learn Quicker & More Effectively Optimise Your Athletes' Recovery Position Yourself As An Expert To Your Athletes And Naturally Improve Buy-In Reduce Your Athletes' Injury Ratese Save 100's Of Dollars A Year That Would Otherwise Be Spent On Books, Courses And More Improve Your Athletes' Performance Advance Forward In Your Career, Allowing You To Earn More Money And Work With Elite-Level Athletes Save Yourself The Stress & Worry Of Constantly Trying To Stay Up-To-Date With Sports Science Research
It used to be that surgery for medically refractory epilepsy was big, open and invasive, a treatment of last resort. The landscape has changed in recent decades, with more and more minimally invasive surgical approaches being developed. So what does this mean for the average patient with medically refractory epilepsy? Our guest today is Dr. Jon Willie, Associate Professor, Department of Neurological Surgery, Washington University School of Medicine in St. Louis. He speaks with Dr. Ionnis Karakis, Epileptologist and Adjunct Professor of Neurology at Emory University, about the new landscape of epilepsy surgery. Series 6, Episode 2 Featuring: Guest: Jon T. Willie, MD, PhD, FAANS, Associate Professor, Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri Interviewer: Ioannis Karakis, MD, PhD, MSc., Epileptologist and Adjunct Professor of Neurology at Emory University Disclosures: Dr. Karakis disclosed that he is a consultant for USB, GSK, Ceribell, and Epitel. Dr. Willie disclosed Consulting for Clearpoint, Inc, AiM Medical Robotics, Inc., and Fortec Medical, Inc.; Contracted Research with Abbott, Inc., Neurona, Inc., and Neuropace, Inc.; and Honoraria from Medtronic, Inc.
For certain diagnoses and patients who meet clinical criteria, neuromodulation can provide profound, long-lasting relief that significantly improves quality of life. In this episode, Aaron Berkowitz, MD, PhD, FAAN speaks with Prasad Shirvalkar, MD, PhD, author of the article “Neuromodulation for Neuropathic Pain Syndromes,” in the Continuum® October 2024 Pain Management in Neurology issue. Dr. Berkowitz is a Continuum® Audio interviewer and a professor of neurology at the University of California San Francisco in the Department of Neurology and a neurohospitalist, general neurologist, and clinician educator at the San Francisco VA Medical Center at the San Francisco General Hospital in San Francisco, California. Dr. Shirvalkar is an associate professor in the Departments of Anesthesia and Perioperative Care, Neurological Surgery, and Neurology at Weill Institute for Neurosciences at the University of California, San Francisco in San Francisco, California. Additional Resources Read the article: Neuromodulation for Neuropathic Pain Syndromes Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @AaronLBerkowitz Guest: @PrasadShirvalka Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor in Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors, who are the leading experts in their fields. Subscribers to the Continuum Journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Berkowitz: This is Dr Aaron Berkowitz, and today I'm interviewing Dr Prasad Shirvalkar about his article on neuromodulation for painful neuropathic diseases, which appears in the October 2024 Continuum issue on pain management in neurology. Welcome to the podcast, and if you wouldn't mind, please introducing yourself to our listeners. Dr Shirvalkar: Thanks, Aaron. Yes, of course. So, my name is Prasad Shirvalkar. I'm an associate professor in anesthesiology, neurology and neurological surgery at UCSF. I am one of those rare neurologists that's actually a pain physician. Dr Berkowitz: Fantastic. And we're excited to have you here and talk to you more about being a neurologist in in the field of pain. So, you wrote a fascinating article here about current and emerging neuromodulation devices and techniques being used to treat chronic pain. And in our interview today, I'm hoping to learn and for our listeners to learn about these devices and techniques and how to determine which patients may benefit from them. But before we get into some of the clinical aspects here, can you first just give our listeners an overview of the basic principles of how neuromodulation of various regions of the nervous system is thought to reduce pain? Dr Shirvalkar: Yeah, I would love to try. But I will promise you that I will not succeed because I think to a large extent, we don't understand how neuromodulation works to treat pain, to describe or to define neuromodulation. Neuromodulation is often described as using electrical stimuli or a chemical stimuli to alter nervous system activity to really influence local activity, but also kind of distant network activity that might be producing pain. On one level, we don't fully understand how pain arises, specifically how chronic pain arises in the nervous system. It's a huge focus of study from the NIH Heal Initiative and many labs around the world. But acute pain, which is kind of when you stub your toe or you burn your finger, is thought to be quite different from the changes over time and the kind of plasticity that produces emotional, cognitive and sensory dimensions. Really what I think is its own disease, chronic pain, of which there are multiple syndromes when we use neuromodulation, either peripheral nerve stimulation or electrical spinal cord stimulation. One common or predominant theory actually comes from a paper in science from 1967 and people still use it, foundational theory and it's called the gate control theory. Two authors, Melzack and Wall, postulated that at the spinal level, there are, there's a local inhibitory circuit or, you know, there's a local circuit where if you provide input to either peripheral nerves or either spinal cord ascending fibers that to kind of summarize it, there's only so much bandwidth, you know, that nerves can carry. And so that if you literally pass through artificial signals electrically, that you will help gate out or block natural pathological but natural pain signals that might be arising from the periphery or spinal cord. So, you know, one idea is that you are kind of interfering with activity that's arising for chemical neuromodulation. The most common is something known as intrathecal drug infusion drug delivery ITTD for that we quite literally put a catheter in the spinal fluid, you know, at the level of the dorsal horn neurons that we think are responsible for perpetuating or creating the pain. Where's the pain generator? And you really, you can infuse local anesthetic, you can infuse opioids. And what's nice is you avoid a lot of systemic side effects and toxicity because it goes right to the spinal cord, you know, by infusing in the fluid. So there's a couple of modalities, but I will say just, like maybe all of our living experience, pain is in the brain. And so, we don't really understand, I would say, what neuromodulation is doing to the higher spinal or brain levels. Dr Berkowitz: Fascinating topic. And yeah, very interesting to hear both what our current understanding is that some of our current understanding is based on data that's 60 years old and that we're actually probably learning about pain by using these modulation techniques, even though we don't really understand how they might be working. So interesting feedback loop there as well as in as in the as in this land. So, your article very nicely organizes the neuromodulation techniques from peripheral to central. So, encourage our listeners to check out your article. And first before we get into some of the clinical applications, just to give the listeners the lay of the land, can you sort of lay out the devices and techniques available for treating pain at each level of the neuroaxis? We'll get into some of the indications in patient selection in a moment, but just sort of to lay out the landscape. What's available that you and your colleagues can use or implant at different levels when we're thinking of referring patients too? Dr Shirvalkar: Absolutely. So, starting from the least invasive or you know, over the counter patients can purchase themselves a TENS machine. Many folks listening to this have probably tried a TENS machine in the past. And the idea is that you put a couple of pads, at least two. So you have like a dipole or you have a positive and a negative lead and you basically inject some current. So, the pads are attached to a battery and you can put these pads over muscle. If you have areas where myofascial pain or sore muscles, you can put them, frankly, over nerves as well and stimulate nerves that are deeper. Most TENS machines kind of use electrical pulses that occur at different rates. You change the rates, you can change the amplitude and patient can kind of have control for what works best. Then getting slightly more invasive, we can often stimulate electrically peripheral nerves. To do this we implant through a needle, a small wire that consists of anywhere from one electrical contact to four or even eight electrical contact. What I think is particularly cool, like TENS, which is transcutaneous electrical nerve stimulation that goes through the skin. Peripheral nerve stimulation aims to stimulate nerves, but you don't have to be right up against the nerve. So, yeah. We typically do this under an ultrasound and you can visualize a nerve like the sciatic nerve, peroneal nerve, or you know, even if someone has an ulnar or a neuropathy, you know, that's the compression. There's a role obviously for surgery and release, but if they have predominantly pain, it's not related to a mechanical problem per se, you could prevent a wire from a peripheral nerve stimulator as far as one centimeter from a nerve and it'll actually stimulate that that modulated and then, you know, kind of progressing even more deeply. The spinal cord stimulation, SCS, it's probably the most ubiquitous or popular form of neuromodulation for pain. People use it for all kinds of diseases. But what it roughly involves is a trial period, which is a placement of either two cylindrical wires, not directly over the spinal cord, but actually in the epidural space, right? So, it's kind of like when you get an epidural injection or doing labor and delivery, when women get epidural catheters, placing spinal cord stimulator leads in that same potential space outside the dura, and you're stimulating through the dura to actually target the ascending dorsal column fibers. And so, you do a trial period or a test drive where the patients get these wires put in. They're coming out of the skin, they're connected to a battery, and they walk around at home for about a week, take careful notes, check in with them, and they keep a diary or a log about how much it helps. Separately. I will say it's hard to distinguish this, the placebo effect often, but you know, sometimes we want to use the placebo effect in clinical practice, but it is a concern, you know, with such invasive things. But you know, if the trial works well, right, you basically can either keep the leads where they are and place a battery internally. And it's for neurologists. You're familiar with deep brain stimulation. These devices are very similar to DVS devices, but they're specifically made for spinal cord stimulation. And there's now like seven companies that offer manufacturers that offer it, each with their own proprietary algorithm or workflow. But going yet more invasive, there is intrathecal drug delivery, which I mentioned, which involves placement of the spinal catheter and infusion of drug into spinal fluid. You could do a trial for that as well. Keep a patient in the hospital for a few days. You've all probably had experience with lumbar drains. It's something real similar. It just goes the other way. You know, you're infusing drugs, and it could also target peripheral nerves or nerve roots with catheters, and that's often done. And last but not least, there's brain stimulation. Right now, it's all experimental except for some forms of TMS or transcranial magnetic stimulation, which is FDA approved for migraine with aura. There are tens machine type devices, cutaneous like stimulators where you can wear on your head like a crown or with stickers for various sorts of migraines. I don't really talk about them too much in in the article, but if there's a fast field out there for adjunctive therapy as well, Dr Berkowitz: Fantastic. That's a phenomenal overview. Just so we have the lay on the land of these devices. So, from peripheral essentially have peripheral nerve stimulators, spinal cord stimulators, intrathecal drug delivery devices and then techniques we use in other areas of neurology emerging for pain DBS deep brain stimulation and TMS transcranial magnetic stimulation. OK let's get into some clinical applications now. Let's start with spinal cord stimulators, which - correct me if I'm wrong - seem to be probably the most commonly seen in practice. Which patients can benefit from spinal cord stimulators? When should we think about referring a patient to you and your colleagues for consideration of implantation of one of these spinal cord stimulator devices? Dr Shirvalkar: So, you know, it's a great question. I would say it's interesting how to define which patients or diagnosis might be appropriate. Technically, spinal cord stimulators are approved for the treatment of most recently diabetic peripheral neuropathy. And so, I think that's a really great category if you have patients who have been failed by more conservative treatments, physical therapy, etcetera, but more commonly even going back, neuropathic low back pain and neuropathic leg pain. And so, you think about it and it's like, how do you define neuropathic pain. Neuropathic pain is kind of broadly defined as any pain that's caused by injury or some kind of lesion in the somatosensory nervous system. We now broaden that to be more than just somatosensory nervous system, but still, what if you can't find a lesion, but the pain still feels or seems neuropathic. Clinically, if something is neuropathic, we often use certain qualitative descriptors to describe that type of pain burning, stabbing, electric light, shooting radiates. There's often hyperpathia, like it lingers and spreads in space and time as opposed to, you know, arthritis, throbbing dull pain or as opposed to muscle pain might be myofascial pain, but sometimes it's hard to tell. So, there aren't great decision tools, I would say to help decide. One of the most common syndromes that we use spinal cord stimulation for is what used to be called failed back surgery syndrome. We never like to, we now try to shy away from explicitly saying something is someone has failed in their clinical treatment. So, the euphemism is now, you know, post-laminectomy syndrome. But in any case, if someone has had back surgery and they still have a nervy or neuropathic type pain, either shooting down their legs and often there's no evidence on MRI or even EMG that that something is wrong, they might be a good candidate, especially if they're relying on long term medications that have side effects or things like full agonist opioids, you know that that might have side effects or contraindication. So, I would say one, it's not a first line treatment. It's usually after you've gone through physical therapy for sure. So, you've gone through tried some medications. Basically, if chronic pain is still impacting your life and your function in a meaningful way that's restricting the things you want to do, then it it's totally appropriate, I think, to think about spinal cord stimulation. And importantly, I will add a huge predictor of final court stimulation success is psychological composition, you know, making sure the person doesn't have any untreated psychological illness and, and actually making sure their expectations going in are realistic. You're not going to cure anyone's pain. You may and that's, you know, a win, but it's very unlikely. And so, give folks the expectation that we hope to reduce your pain by 50% or we want you to list personally, I like functional goals where you say what is your pain preventing you from doing? We want to see if you can do X,Y, and Z during the trial period. Pharmacostimulation right now. Yeah. Biggest indication low back leg pain, Diabetic peripheral neuropathy. There is also an indication for CRPS, complex regional pain syndrome, a lesser, I'd say less common but also very debilitating pain condition. For better or worse. Tertiary quaternary care centers. You often will see spinal cord stem used off label for neuropathic type pain syndromes that are not explicitly better. That may be for example, like a nerve injury that's peripheral, you know, it's not responding. A lot of this off label use is highly variable and, you know, on the whole at a population level not very successful. And so, I think there's been a lot of mixed evidence. So, it's something to be aware about. Dr Berkowitz: That's a very helpful framework. So, thinking about referring patients to who have most commonly probably the patients with chronic low back pain have undergone surgery, have undergone physical therapy, are on medications, have undergone treatment for any potential psychological psychiatric comorbidities, and yet remain disabled by this pain and have a reasonable expectation and goals that you think would make them a good candidate for the procedure. Are those similar principles to peripheral nerve stimulation I wasn't familiar with that technique, I'm reading your article, so are the principles similar and if so, which particular conditions would potentially benefit from referral for a trial peripheral nerve stimulation as opposed to spinal cord stimulation? Dr Shirvalkar: Yeah, the principles are similar overall. The peripheral nerve stimulation, you know, neuropathic pain with all the characteristics you listed. Interestingly enough, just like spinal cord stim, most insurances require a psychological evaluation for peripheral nerve stim as well. And we want to make sure again that their expectations are reside, they have good social support and they understand the kind of risks of an invasive device. But also, for peripheral nerve stem, specifically, if someone has a traumatic injury of an individual peripheral nerve, often we will consider it seeing kind of super scapular stimulation. Often with folks who've had shoulder injuries or even sciatic nerve stimulation. I have done a few peroneal nerve stimulations as well as occipital nerve stimulation from migraine, so oxygen nerve stimulation has been studied a lot. So, it's still somewhat controversial, but in the right patient it can actually be really helpful. Dr Berkowitz: Very helpful. So, these are patients who have neuropathic pain, but limited to one peripheral nerve distribution as opposed to the more widespread back associated pains, spine associated pains. Dr Shirvalkar: Yeah, Yeah, that's right. And maybe there's one exception actually to this, which is brachial plexopathy. So, you know, folks who've had something like a brachial plexus avulsion or some kind of traumatic injury to their plexus, there is I think good Class 2 evidence that peripheral nerve stem can work. It falls under the indication. No one is as far as to my knowledge, No one's done an explicit trial, you know PNS randomized controlled trial. Yeah, that's, you know, another area one area where PNS or peripheral nerve stems emerging is actually, believe it or not in myofascial low back pain to actually provide muscle stimulation. There are some, there's a company or two out there that seeks to alter the physiology of the multifidus muscle, one of your spinal stabilizer muscles to really see if that can help low back pain. And they've had some interesting results. Dr Berkowitz: Very interesting. You mentioned TENS units earlier, transcutaneous electrical nerve stimulation as something a patient could get over the counter. When would you encourage a patient to try TENS and when would you consider TENS inadequate and really be thinking about a peripheral nerve stimulator? Dr Shirvalkar: Yeah, you know TENS we think of as really appropriate for myofascial pain. Folks who have muscular pain, have clear trigger points or taught muscle bands can often get relief from TENS If you turn a TENS machine up too high, you'll actually see muscle infection. So, there's an optimal level where you actually can turn it up to induce, like, a gentle vibration. And so folks will feel paresthesia and vibrations, and that's kind of the sweet spot. However, I would say if folks have pain that's limited or temporary in time or after a particular activity, TENS can be really helpful. The unfortunate reality is TENS often has very time-limited benefits - just while you're wearing it, you know? So, it's often not enduring. And so that's one of the limitations. Dr Berkowitz: That's helpful to understand. We've talked about the present landscape in your article, also talk a little bit about the future and you alluded to this earlier. Tell us a little bit about some off label emerging techniques that we may see in future use. Who, which types of patients, which conditions might we be referring to you and your colleagues for deep brain stimulation or transcranial magnetic stimulation or motor cortex stimulation? What's coming down the pipeline here? Dr Shirvalkar: That's a great question. You know, one of my favorite topics is deep brain stimulation. I run the laboratory that studies intracranial signals trying to understand how pain is processed in the brain. But, believe it or not, chronic pain is probably the oldest indication for which DBS has been studied. the first paper came out in 1960, I believe, in France. And you know, the, the original pivotal trials occurred even before the Parkinson's trial and so fell out of favor because in my opinion, I think it was just too hard or too difficult or a problem or too heterogeneous. You know, many things, but there are many central pain syndromes, you know, poststroke pains, there's often pains associated with Parkinson's disease, epilepsy, or other brain disorders for which we just don't have good circuit understanding or good targets. So, I think what's coming down the pipeline is a better personalized target identification, understanding where can we stimulate to actually alleviate pain. The other big trend I think in neuromodulation is using closed loop stimulation which means in contrast to traditional electrical stimulation which is on all the time, you know it's 24/7, set it and forget it. Actually, having stimulation respond or adapt to ongoing physiological signals. So that's something that we're seeing in spinal cord stem, but also trying to develop in deep brain stimulation and noninvasive stimulation. TMS is interestingly approved for neuropathic pain in Europe, but not approved by the FDA in the US. And so I think we may see that coming out of pipeline broader indication. And finally, MR guided focused ultrasound is, is a kind of a brand new technique now. You know, focused ultrasound lesions are being used for essential tremor without even making an incision in the skull or drilling in skull. But there are ways to modulate the brain without lesioning. And, you know, I think a lot of research will be emerging on that in the next five years for, for pain and many other neuronal disorders. Dr Berkowitz: That's fascinating. I didn't know that history that DBS was first studied for pain and now we think of it mostly for Parkinson's and other movement disorders. And now the cycle is coming back around to look at it for pain again. What are some of the targets that are being studied that are thought to have benefit or are being shown by your work and that of others to have benefit as far as DBS targets for, for chronic pain? Dr Shirvalkar: You know, that's a great question. And so, the hard part is finding one target that works for all patients. So, it may actually require personalization and actually understanding what brain circuit phenotypes do you have with regards to your chronic pain and then based on that, what target might we use? But I will say the older targets. Classical targets were periaqueductal gray, which is kind of the opioid center in your brain. You know, it's thought to just release large amounts of endogenous opioids when you stimulate there and then the ventral pusher thalamus, right. So, the sensory ascending system may be through gait control theory interferes with pain, but newer targets the answer singlet there's some interest in in stimulating there again, it doesn't work for everybody. We found some interesting findings with the medial thalamus as well as aspects of the caudate and other basal ganglion nuclei that we hopefully will be publishing soon in a data science paper. Dr Berkowitz: Fantastic. That's exciting to hear and encourage all of our listeners to check out your article. That goes into a lot more depth than we had time to do in this short interview, both about the science and about the clinical indications, pros and cons, risks and benefits of some of these techniques. So again, today I've been interviewing Dr Prasad Shirvalkar, whose article on neuromodulation for painful neuropathic diseases appears in the most recent issue of Continuum on pain management in neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you again to our listeners for joining today. Dr Shirvalkar: Thank you for having me. It was an honor. Dr Monteith: This is Dr Teshamae Monteith, associate editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in depth and clinically relevant information important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/AudioCME. Thank you for listening to Continuum Audio.
SoCal Election Drama: Did you hear... there's an election coming. As much as we say California is already decided so the election isn't a big deal nationally, we are underestimating the political diversity in the State. Election Violence: Federal authorities have been working with county elections officials and law enforcement in Southern California to prepare for Election Day, a part of broader national efforts to monitor elections amid concerns over threats to public safety and democracy. LA Law: The Law Makers, Law Breakers and times that there oughta be a law. DST: Roughly a century later, we're still giving ourselves jet lag without flying anywhere. Why do we still do this? Because “no one can agree on exactly where to keep the time,” said Heinrich Gompf, a sleep researcher with UC Davis Health's Department of Neurological Surgery.
This continuing education activity is provided by AffinityCE and CheckRare CE. This activity provides continuing education credit for physicians. A statement of participation is available for other attendees. Estimated time to complete: 0.50 hoursTo obtain CME credit, go to https://checkrare.com/learning/p-cushings-syndrome-treatment-research-highlights-endo-2024/Commercial SupportEducational Support for this activity was provided by Recordati Rare Diseases, Inc., and Xeris Pharmaceuticals.Learning ObjectiveAfter participating in the activity, learners should be better able to:Describe the latest research being presented to better manage individuals with Cushing's syndrome and its clinical relevance.Share new information with their clinical team. Activity DescriptionThis 30-minute CME program highlights the latest clinical research about Cushing's syndrome and Cushing' disease.Cushing's syndrome is rare endocrine disorder characterized by chronic hypercortisolism. It is often due to a pituitary adenoma producing excessive ACTH leading to hypercortisolism. Symptoms can range from mild to extensive.This CME program, hosted by Maria Fleseriu, MD, FACE, Professor of Medicine and Neurological Surgery, Director of the Pituitary Center at Oregon Health & Science University, provides an overview of the latest clinical research presented at ENDO 20234 involving Cushing's syndrome. FacultyMaria Fleseriu, MD, FACEProfessor of Medicine and Neurological SurgeryDirector of Pituitary CenterOregon Health & Science UniversityPortland, OregonDisclosure StatementAffinityCE and CheckRare CE staff, as well as planning and review committees, have no financial interests to disclose. Faculty EducatorsDr. Fleseriu discloses the following relevant financial relationships with ineligible companies to disclose:Funding to the University as Principle Investigator from Sparrow PharmaceuticalsScientific consultant for Crinetics Pharmaceuticals, Recordati Rare Diseases, Sparrow Pharmaceuticals, and Xeris PharmaceuticalsMitigation of Relevant Financial Relationships AffinityCE adheres to the ACCME's Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CME activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible companies. Method of ParticipationThere are no fees to participate in the activity. Participants must review the activity information including the learning objectives and disclosure statements, as well as the content of the activity. To receive CME credit for your participation, please complete the pre- and post-program assessments. Your certificate will be emailed to you in within 30 days.Participation CostsThere is no cost to participate in this CME session. To receive CME credit for your participation, please complete the pre- and post-program assessments. Your certificate will be emailed to you in within 30 days.CME InquiriesFor all CME policy-related inquiries, please contact us at ce@affinityced.com.Send customer support requests to cds_support+ldrtc@affinityced.com.Copyright© 2024. This CME-certified activity is held as copyrighted © by AffinityCE and CheckRare CE. Through this notice, AffinityCE and CheckRare CE grant permission of its use for educational purposes only. These materials may not be used, in whole or in part, for any commercial purposes without prior permission in writing from the copyright owner(s).
In a conversation with CancerNetwork®, Nader Sanai, MD discussed the current state of the glioblastoma field, highlighting ongoing research efforts to help improve outcomes among patients with this disease. Sanai is the director of the Ivy Brain Tumor Center and J.N Harber Professor of Neurological Surgery, Francis and Dionne Najafi chair for Neurosurgical Oncology, and chief of neurological oncology at Barrow Neurological Institute. Specifically, Sanai described plans to assess treatment with niraparib (Zejula) compared with temozolomide (Temodar) in a population of patients with newly diagnosed MGMT unmethylated glioblastoma as part of the phase 3 Gliofocus study (NCT06388733).1 He contextualized the rationale for conducting this study by focusing on findings from a proof-of-concept hybrid study (NCT05076513) and detailing how they supported additional investigation into the utility of niraparib. According to findings from this proof-of-concept study presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, the median overall survival (OS) was 20.3 months among patients who received niraparib in combination with radiotherapy.2 Additionally, data showed that niraparib reached drug concentrations in Gadolinium-nonenhancing newly diagnosed glioblastoma tissue exceeding those of any other evaluated PARP inhibitors; investigators identified no new safety signals after combining niraparib with radiotherapy in this population. With the Gliofocus trial, Sanai and co-investigators aim to provide a clinically meaningful quality of life benefit with niraparib-based therapy beyond a marginally valuable statistical advantage. By evaluating treatment with niraparib, investigators look to improve historical survival rates reported with standard-of-care options among patients with unmethylated disease. “What we're looking to do with this trial is set a benchmark that's clinically relevant for patients and providers. The [OS] target for the study is 18 months, which is to effectively convert [a] 12-month natural history to a natural history closer to the methylated glioblastoma population,” Sanai said. “We think that is a meaningful transformation of a difficult patient population, a significant chunk of survival time that would be beneficial to patients, providers, and caregivers. Importantly, [it may also mean] an advantage for quality of life, which is of paramount importance for this patient population.” References 1. A study comparing niraparib with temozolomide in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma. ClinicalTrials.gov. Updated June 24, 2024. Accessed September 16, 2024. https://tinyurl.com/y25er8p9 2. Sanai N, Umemura Y, Margaryan T, et al. Niraparib efficacy in patients with newly-diagnosed glioblastoma: Clinical readout of a phase 0/2 "trigger" trial. J Clin Oncol. 2024;42(suppl 16):2002. doi:10.1200/JCO.2024.42.16_suppl.2002
In this episode of The Glioblastoma AKA GBM Podcast, Dr. Ashish Shah, Assistant Professor of Neurological Surgery at the University of Miami Miller School of Medicine and Director of Clinical Trials and Translational Research within the University of Miami Brain Tumor Initiative, dives deep into his groundbreaking research on glioblastoma. Dr. Shah discusses a fascinating study revealing how fragments of a retrovirus, integrated into the human genome millions of years ago, are implicated in the proliferation and progression of glioblastoma, the most aggressive primary brain tumor. This episode explores how these findings from Dr. Shah's research at the Sylvester Comprehensive Cancer Center could revolutionize our understanding of glioblastoma and lead to novel treatment strategies. We also delve into the potential of antiretroviral agents and gene therapy as innovative approaches to target these viral fragments, opening new avenues for combatting this challenging cancer. Episode Sponsor: Novocure. Visit https://www.novocure.com/ to learn more. Trigger Warning: This episode includes discussions on medical conditions, cancer treatments, and genetic research. Visit to Learn More: For more information and support resources, visit GBMResearch.org. Disclaimer: The content discussed on The Glioblastoma AKA GBM Podcast is based on personal stories and experiences. It is not intended as medical advice. Always consult with healthcare professionals for medical guidance and treatment options.
Healthcare is changing rapidly. Tomorrow's cure is already here today. How do top medical educational institutes prepare and equip the workforce for the fast-changing healthcare landscape? Find out from our featured experts: Dr. Fredric Meyer, Executive Dean of Education, Enterprise Chair of Neurological Surgery at Mayo Clinic; and Dr. James Stoller, Chair of Education Institute at Cleveland Clinic.
How can we break through the barriers in communication for millions suffering from speech impairments due to ALS, stroke, and other conditions? Traditional assistive technologies, like eye trackers, are slow and cumbersome, limiting effective communication. However, ongoing research in speech neuroprosthetics shows promising results in restoring seamless communication by decoding speech directly from brain signals. Enter the groundbreaking work where Dr. Nicholas S. Card and Dr. Maitreyee Wairagkar are bringing change in the development of speech neuroprosthesis. Their award-winning project lead by Dr. David M. Brandman and Dr. Sergey D. Stavisky from UC Davis in collaboration with Stanford, and Brown University teams, introduces a rapidly deployable high-performance speech neuroprosthesis. This innovative technology can convert brain signals into text and voice in real-time, significantly enhancing communication speed and quality for individuals with severe speech impairments. In this episode, Nick and Maitreyee share their journey of creating a multimodal speech neuroprosthesis and their challenges and remarkable achievements. Learn about their approach to decoding phonemes, integrating large language models, and synthesizing intelligible speech directly from neural activity. They also delve into their career development journeys, offering valuable advice for those aspiring to follow in their footsteps. Additionally, they provide insights into the BCI Award submission process, sharing tips for a successful application. Whether you're fascinated by neuroscience, intrigued by BCI technology, or looking for career inspiration, this episode is packed with valuable knowledge and advice. Tune in to discover how Nick and Maitreyee are revolutionizing the field of neuroprosthetics and making a profound impact on the lives of people with speech impairments. About the Podcast Guests: Dr. Maitreyee Wairagkar Affiliation: Department of Neurological Surgery, University of California, Davis Email: mwairagkar@ucdavis.edu Social (X): @Maitreyee_W Personal website: maitreyeew.github.io Lab website: neuroprosthetics.science BrainGate website: braingate.org Bio: Dr. Maitreyee Wairagkar is a neuroscientist and neuroengineer dedicated to developing advanced neurotechnology through artificial intelligence. As a Postdoctoral Scholar at the University of California, Davis, she has created implanted brain-computer interfaces (BCIs) that allow individuals with severe speech and motor impairments to communicate directly via brain signals. Dr. Wairagkar's work spans healthcare applications of neurotechnology, including neurorehabilitation for stroke recovery and robotic care for dementia. Her prior research in stroke rehabilitation technology has been commercially translated, showcasing her commitment to impactful innovation in neurotechnology. Dr. Nicholas S. Card Affiliation: Neuroprosthetics Lab, University of California, Davis Email: [provided upon request] Lab website: neuroprosthetics.science BrainGate website: braingate.org Bio: Dr. Nicholas S. Card is a postdoctoral scholar in the Neuroprosthetics Lab at the University of California, Davis, and a member of the BrainGate consortium. His research focuses on understanding how speech is encoded in the brain and developing brain-computer interfaces (BCIs) to decode speech from cortical signals in individuals with brain injuries or diseases that impair communication. Dr. Card's work aims to transform neuroprosthetic technology, enabling seamless communication for those with speech impairments, further advancing the field of neuroengineering. About the Podcast Host: The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a neuroscience educator, research consultant, and career coach for people in neuroscience and neurotechnologies. As a professional coach with a background in the field, Dr. K understands the unique challenges and opportunities job applicants face in this field and can provide personalized coaching and support to help you succeed. Here's what you'll get with one-on-one coaching sessions from Dr. K: Identification and pursuit of career goals Guidance on job search strategies, resume, and cover letter development Neurotech / neuroscience job interview preparation and practice Networking strategies to connect with professionals in the field of neuroscience and neurotechnologies Ongoing support and guidance to help you stay on track and achieve your goals You can always schedule a free neurocareer consultation/coaching session with Dr. K at https://neuroapproaches.as.me/free-neurocareer-consultation Subscribe to our Nerocareers Newsletter to stay on top of all our cool neurocareers news at updates https://www.neuroapproaches.org/neurocareers-news
If you're an ASOPRS Member, Surgeon or Trainee and are interesting in hosting a podcast episode, please submit your idea by visiting: asoprs.memberclicks.net/podcast Dr. Evan Kalin-Hajdu - Assistant Professor of Ophthalmology at the University of Montreal. Dr. Kalin-Hajdu is the host of the current "Oculofacial Podcast Journal Club". Dr. Bryan J. Winn - Professor of Ophthalmology and Vice Chair and Division Director for Oculofacial Plastic Surgery at UCSF. He also serves as the Chief of Ophthalmology at the San Francisco VA Healthcare System. Dr. Davin Ashraf - Assistant Professor of Ophthalmology at Oregon Health & Science University (OHSU). Dr. Kyle J. Godfrey - Assistant Professor of Ophthalmology at Weill Cornell Medicine and the New York Presbyterian Hospital. He is also the Director of the Ophthalmology Residency Program and a member of the Departments of Ophthalmology and Neurological Surgery. Episode Summary: In this engaging episode of the Oculofacial Podcast Journal Club, distinguished host Dr. Evan Kalin-Hajdu from the University of Montreal is joined by renowned experts Dr. Bryan J. Winn, Dr. Davin Ashraf, and Dr. Kyle J. Godfrey to discuss three key articles from the May-June 2024 issue of the Ophthalmic Plastic and Reconstructive Surgery (OPRS) journal. The discussion delves into short-term versus long-term results of teprotumumab, a more custom management of patients with thyroid eye diseases, as well as rapidly popular transorbital surgery. The episode begins with Dr. Bryan J. Winn summarizing an article on teprotumumab for recalcitrant thyroid eye disease. The panelists then discuss the strengths and weaknesses of the paper, highlighting the medication's short-term effectiveness but raising concerns about its long-term durability. Following this, Dr. Davin Ashraf provides insights into a study that compared teprotumumab versus orbital decompression for thyroid eye disease, highlighting the likely additive effects of these combined treatments, but also raising compelling points about regression of proptosis that was only observed in the teprotumumab group. Dr. Kyle J. Godfrey then wraps up with an in-depth look at a novel transorbital endoscopic approach to the foramen rotundum for infraorbital nerve stripping, emphasizing the technique's potential utility, risks, and anatomical considerations. The participants then discussed the growing popularity of transorbital surgery from the standpoint of oculofacial plastic surgeons. Key Takeaways: Teprotumumab's Effectiveness: Teprotumumab shows significant short-term efficacy in reducing proptosis and clinical activity scores in recalcitrant thyroid eye disease, but data on long-term durability remains unknown in that cohort. Teprotumumab versus decompression: Combining teprotumumab with orbital decompression may provide additive benefits for proptosis reduction. Surgical decompression provides the greatest proptosis reduction and does not appear to wane in time. However, patients treated solely with teprotumumab appear to start regressing within months of therapy. Evolving Treatment Protocols: The participants theorize a potential shift in managing thyroid eye disease, gradually incorporating a more evidence-based approach with an effective short-term modulator, like teprotumumab, followed by a long-term disease modifier, like tocilizumab or radiation therapy. Advanced Surgical Techniques: Introducing a transorbital endoscopic approach for infraorbital nerve stripping could expand the surgical arsenal for managing complex orbital and perineural pathologies. Resources: Dr. Evan Kalin-Hajdu: University of Montreal Dr. Bryan J. Winn: UCSF Department of Ophthalmology Dr. Davin Ashraf: OHSU Knight Cancer Institute Dr. Kyle J. Godfrey: Weill Cornell Medicine
Today on the show, I welcome Vikram Bhaskaran and Dr. Rohan Ramakrishna (Chief of Neurological Surgery at Weill Cornell Medicine) live in studio to talk about Roon, their intriguing new cancer navigation platform for patients and caregivers. Roon is personal to Vikram as his whole career shifted from Pinterest executive to caring for his Father when he was diagnosed with ALS. Roon claims to be "the most supportive place online for people navigating complex health conditions, starting with Glioblastoma." so we power-test how that holds up against unmet patient needs. Rohan is only the second neurosurgeon I've had on the show, so, as a brain cancer survivor, I naturally asked him all sorts of pointed questions like, "What's it like to touch someone's brain?" These guys are the real deal with core compassion for empathy in medicine and helping patients in need access what they never knew they needed. Enjoy the show.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Phil Starr is a Professor of Neurological Surgery at University of California, San Francisco and a developer of implantable brain devices. At UCSF, he co-directs a multidisciplinary neurology/neurosurgery movement disorders clinic together with Dr. Jill Ostrem. I've been a long-time admirer of Phil's work and in this conversation we blaze through quite a few of his numerous publications. One key breakthrough and invention of Phils work has been to include Ecog recordings – both intraoperatively but also chronically – to investigate brain signals in various states. We talk about the Open Mind Consortium, Mentorship and the cross-pollination between academia and industry. One key highlight of Phils work is a paper which was accepted for publication in Nature Medicine, at the time of recording this just yesterday. In it, the three co-first authors Carina Oehrn, Stephanie Cernera and Lauren Hammer demonstrate the chronic use of a newly identified cortical physiomarker, which is now referred to as the finely tuned gamma activity. I hope you enjoy this conversation as much as I did, and thank you for tuning into Stimulating Brains!
Datshiane Navanayagam speaks to two female neurosurgeons to hear about the pressures and rewards that come from working in their intense and male-dominated medical field. Dr. Lola Chambless is an American neurosurgeon based in Nashville. She is passionate about medical education and serves as the Residency Program Director in Neurological Surgery. Dr. Giselle Coelho is an award-winning paediatric neurosurgeon from Brazil who has a PhD from Harvard. She is currently the Scientific Director of the EDUCSIM Institute and works at Sabará Hospital.(Image: (L) Dr. Lola Chambless, credit Vanderbilt University Medical Center. (R) Dr. Giselle Coelho, credit Trianon Clinic.)
Dr. Joseph Maroon is a World-Renowned NeurosurgeonHe's also my mentor, friend, and the primary reason I became a neurosurgeon.Today, an incredible talk with one of the giants of my profession about legacy, hardship, mindset, faith, and more. You should read Dr. Maroon's excellent book, Square One:A Simple Guide To A Balanced Life. Official Bio:Joe is clinical professor and vice-chairman of the Department of Neurological Surgery and the Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center. He received his education at Georgetown and Oxford Universities, the University of Vermont, and Indiana University in Bloomington, where he is a distinguished alumnus. He has authored over 280 peer-reviewed scientific papers and six previous books, including Fish Oil: The Natural Anti-Inflammatory and The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life. Joe is a sports medicine expert and has served as the team neurosurgeon for the Pittsburgh Steelers for over 20 years. He is also a member of the NFL Head, Neck and Spine Committee, and is the medical director for World Wrestling Entertainment. In the early 1990s, Joe co-developed the ImPACT concussion test, the only FDA-approved, worldwide standard tool to assess concussions. He is the senior vice president of the American Academy of Anti-Aging Medicine; chairs the scientific advisory board of both Mylan and Stemedica; and is the scientific consultant for GNC. Joe is an inductee in both the National Fitness and the Lou Holtz Halls of Fame and remains a dedicated athlete, having completed eight Ironman triathlons-including five world championships in Kona, Hawaii-as well as over 70 other elite marathon and triathlon events. To learn more about Dr. Maroon, visit www.josephmaroon.comLeave a voicemail with your question or comment!Five Ways You Can Support this show:Pray for us!Subscribe, like, and share it with your friends! (We even have a YouTube channel!)Leave reviews and comments wherever you listen to podcasts!You can become a paid partner of the podcast and get special bonus episodes and lots more content by clicking here. Visit one of our affiliate partners and consider using their products (we use them every day):Improve your gut health, immune system, and protect your brain with Pique!Other Helpful Links:Click here to access the Hope Is the First Dose playlist of hopeful, healing songs!Be sure to check out my new book, Hope Is the First Dose!Here's a free 5-day Bible study on YouVersion/BibleApp based on my new book!Sign up for my weekly Self-Brain Surgery Newsletter here!All recent episodes with transcripts are available here! (00:01) - Introduction to Dr. Joe Maroon (08:24) - Visionary Microsurgery Techniques (12:25) - Reconnecting with Dr. Maroon (16:14) - Honoring the Opportunity to Train (21:46) - Importance of Faith and Gratitude (25:58) - Transformation Through Running and Triathlons (29:59) - The Power of Preparation (33:25) - The Influence of Early Connections (37:49) - Understanding the Frontal Lobes (40:46) - Benefiting from Past Innovations (42:18) - Building on the Legacy of Pioneers (46:32) - Navigating Major Adversity (49:09) - Mindful Awareness and Stress Management (53:31) - Gratitude and Mindset Shifts (56:47) - Changing Your Mind, Changing Your Life
ESPN, AP, USA Today, NFL Neurosurgeon, Ironman TriathleteIt is not everyday that I get to speak to a renowned neurosurgeon for the NFL. Yes! The National Football League. In addition, long time team neurosurgeon for the Pittsburgh SteelersMarch 4, 2022 The NFL Physicians Society (NFLPS) awarded the Arthur C. Rettig Award for Academic Excellence to Joseph C. Maroon, MD. Dr. Maroon is a neurosurgeon for the Pittsburgh Steelers for 38 years and recently presented at the NFLPS scientific meeting during the 2022 NFL Scouting Combine. Dr. Maroon is the first Neurosurgeon to receive this award.Joseph C. Maroon, M.D., FACS, is Professor and Vice chairman of the Department of Neurological Surgery and Heindl Scholar in Neuroscience at the University of Pittsburgh Medical Center. He is a world-renowned neurosurgeon, health and nutrition expert and Ironman triathlete. He obtained his medical and neurosurgical training at Indiana University, Georgetown University, Oxford University in England and the University of Vermont. He is regarded as a premiere specialist in the surgical treatment of injuries and diseases of the brain and spine, particularly with microscopic and minimally invasive procedures. He had done extensive research into brain tumors, concussions and diseases of the spine that have led to many innovative techniques for diagnosing and treating these disorders. Consistently listed in America's Best Doctors, he has an international referral baseTeam neurosurgeon for the Pittsburgh Steelers since 1981, Dr. Maroon has successfully performed surgery on numerous professional football players and other elite athletes with potentially career-ending neck and spine injuries, safely returning them all to their high level of athletic performance. He serves on the National Football League's Mild Traumatic Brain Injury Committee. Along with Mark Lovell, Ph.D., in the early 1990's, Dr. Maroon co-developed ImPACT™ (Immediate Post-Concussion Assessment and Cognitive Testing), the first, most-widely used and most scientifically validated computerized concussion evaluation system. ImPACT is a 20-minute test that has become a world-wide standard tool used in comprehensive clinical management of sports-related concussions for athletes of all ages. Over 3 million athletes have been base-lined with ImPACT™.Dr. Maroon is frequently quoted as an expert source by national media, recently including the New York Times, USA Today, Associated Press, ESPN, Sports Illustrated.© 2024 Building Abundant Success!!2024 All Rights Reserved Join Me on ~ iHeart Media @ https://tinyurl.com/iHeartBASSpot Me on Spotify: https://tinyurl.com/yxuy23baAmazon ~ https://tinyurl.com/AmzBASAudacy: https://tinyurl.com/BASAud
For over a century, different surgical interventions have been explored to address symptoms of Parkinson's disease, and researchers are continuing to innovate and improve surgical treatments today. With new technology and an ever-expanding understanding of the function of the nervous system and the pathophysiology of Parkinson's disease, neurosurgical interventions are becoming more effective and more personalized. Dr. Doris Wang joins us in this episode to discuss her work using focused ultrasound and deep brain stimulation (DBS) as treatments for Parkinson's disease and other movement disorders. She discusses some of the benefits and limitations of focused ultrasound treatment, comparisons of traditional versus asleep interventional MRI-guided deep brain stimulation surgery, advances in adaptive deep brain stimulation, and the development of gait-related biomarkers that could drive adaptive DBS. Doris is a neurosurgeon and Associate Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF). This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.
The Parkinson’s Research Podcast: New Discoveries in Neuroscience
For over a century, different surgical interventions have been explored to address symptoms of Parkinson's disease, and researchers are continuing to innovate and improve surgical treatments today. With new technology and an ever-expanding understanding of the function of the nervous system and the pathophysiology of Parkinson's disease, neurosurgical interventions are becoming more effective and more personalized. Dr. Doris Wang joins us in this episode to discuss her work using focused ultrasound and deep brain stimulation (DBS) as treatments for Parkinson's disease and other movement disorders. She discusses some of the benefits and limitations of focused ultrasound treatment, comparisons of traditional versus asleep interventional MRI-guided deep brain stimulation surgery, advances in adaptive deep brain stimulation, and the development of gait-related biomarkers that could drive adaptive DBS. Doris is a neurosurgeon and Associate Professor in the Department of Neurological Surgery at the University of California, San Francisco (UCSF). This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.
Dr. Konstantin Slavin is Professor and Chief of Section and Fellowship Director for Stereotactic and Functional Neurosurgery in the Department of Neurosurgery at the University of Illinois at Chicago (UIC). Dr. Slavin graduated from medical school in Baku, Azerbaijan in the Soviet Union and completed his neurosurgery residency in Moscow. He then completed his second neurosurgery residency at UIC and a fellowship in functional and stereotactic neurosurgery at Oregon Health Sciences University in Portland, Oregon. Dr. Slavin is current President of the World Society for Stereotactic and Functional Neurosurgery and the Past President of the American Society for Stereotactic and Functional Neurosurgery. He is also the President-Elect of the International Neuromodulation Society (INS) and past Secretary of the North American Neuromodulation Society (NANS). For many years, he serves on the Medical Advisory Board of the Facial Pain Association, the premier patient organization for those who suffer from trigeminal neuralgia and other facial pain syndromes. In addition, he is on the Board of non profit organization “Neuromodulation Foundation”, the publisher of Wikistim, and for more than a decade was an Executive Committee member of the Joint Section on Pain of the American Association of Neurological Surgeons and Congress of Neurological Surgeons. Dr. Slavin has published in many books and peer-reviewed journals and is an associate editor or editorial board member for a number of publications, including Neuromodulation, Neurosurgery, Brain Sciences, Stereotactic and Functional Neurosurgery, Acta Neurochirurgica and others; he is the current editor-in-chief of Progress in Neurological Surgery. His first book on Peripheral Nerve Stimulation was published in 2011; another book, co-edited with Sam Eljamel on Neurostimulation: Practice and Principles, came out in 2013; the third one, Stimulation of Peripheral Nervous System: The Neuromodulation Frontier was released in 2015. The most recent – and most relevant for this audience – book on Neuromodulation for Facial Pain came out in 2021.
Dr. Sheri Dewan is a distinguished neurosurgeon based in Chicago, specializing in complex spine surgery and minimally invasive spine techniques. She holds board certifications in Neurological Surgery and is recognized for her expertise in spinal disorders and neurosurgical procedures. Dr. Dewan is dedicated to advancing neurosurgical practices through her role as a clinical instructor, sharing her knowledge with medical students and residents. Her commitment to patient care is evident in her personalized treatment plans and the use of the latest surgical technologies. Recognized for her contributions to the field, Dr. Dewan has received numerous awards and is highly regarded by her peers and patients alike for her surgical skill and compassionate approach.In this episode, we cover:Dr Dewan's Journey into NeurosurgeryDr. Dewan's new book "Cutting A Path"The cause of pituitary tumors & the new field of Neuroendocrinologyhow to prevent and treat vascular disorders of the brainDr Dewan's biggest insights from her time in the ERand much more Sheri's Links and Resources:Website - https://www.drsheridewan.com/Instagram - https://www.instagram.com/drsheridewan/LinkedIn - https://www.linkedin.com/in/dr-sheri-dewan-350375161/The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner.
What does it take to successfully navigate a career in the ever-evolving landscape of neurotechnologies? What is adaptive deep brain stimulation (DBS), and how is it transforming the lives of those with movement disorders? Today, on "Neurocareers: Doing the Impossible!" we dive into these questions with Dr. Stephanie Cernera, DBS research and development specialist, particularly for Parkinson's disease. Dr. Cernera, with her rich background in Biomedical Engineering from Purdue University and a PhD from the University of Florida, has been at the forefront of pioneering DBS strategies. Her groundbreaking work on closed-loop DBS, utilizing wearable sensors for essential tremor patients, has set new standards in the field. Currently, at the prestigious Starr Lab at UCSF, she develops adaptive DBS protocols that leverage local field potentials for more tailored and responsive treatments for Parkinson's disease and dystonia sufferers. Moreover, Stephanie is making a bold career shift by joining Syhchron - a leader in the neurotech industry. In this episode, Dr. Cernera shares her personal career journey through the realm of neurotech. She offers valuable insights on navigating graduate school and postdoctoral applications and discusses the courage it takes to transition from academia to industry. Her story is not just one of scientific innovation but also of personal resilience and the drive to make a significant impact. Dr. Cernera emphasizes the critical importance of teamwork and effective collaboration in today's research environment. As projects expand in complexity, particularly with the vast amounts of data being collected and the intricate questions needing answers, the ability to work harmoniously within a team becomes indispensable. She points out that a well-coordinated team can offer invaluable feedback on data analyses and methodologies, playing a pivotal role in ensuring the success of developed approaches. Dr. Cernera's insights underline the significance of fostering strong team dynamics and the impact of collaborative effort on achieving breakthrough outcomes in neurotech research. Join us as Dr. Cernera delves into her own neurocareer journey from academic DBS research to her pivotal role at Synchron and shares her expert advice for those looking to forge their own paths in this dynamic field. This episode is a must-listen for anyone intrigued by the nexus of technology, healthcare, and neurotech research, promising to inspire and guide future leaders in neurotech. Tune in to uncover the narrative of a neurocareer that has crossed fields, from the academic study of DBS to the cutting-edge industry work at Synchron, with Dr. Stephanie Cernera. About the Podcast Guest: Stephanie is currently a Postdoctoral Fellow at Starr Lab, Department of Neurological Surgery, University of California, San Francisco and she is currently transitioning to her new role in the neurotech industry at Synchron. All the adaptive work Stephanie has been doing in Dr. Starr's lab has been a massive team effort, and there are two co-first authors on the paper besides Dr. Stephanie Cernera. These are Dr. Carina Oehrn and Dr. Lauren Hammer. The preprint of the paper is available here: https://www.medrxiv.org/content/10.1101/2023.08.03.23293450v1 Stephanie encourages anyone to reach out if they have career questions or research questions - she'd be happy to chat! If you are interested in connecting on LinkedIn - Stephanie's profile is https://www.linkedin.com/in/stephanie-cernera-phd-0a438194/ Stephanie's e-mail is stephcernera@gmail.com Recommended resources from Stephanie: Python on Coursera: https://www.coursera.org/search?query=python Amazon books: https://www.amazon.com/Neural-Data-Science-MATLAB%C2%AE-PythonTM/dp/0128040432 https://www.amazon.com/MATLAB-Neuroscientists-Introduction-Scientific-Computing/dp/0123838363/ref=pd_lpo_3?pd_rd_i=0123838363&psc=1 https://www.amazon.com/MATLAB-Brain-Cognitive-Scientists-Press/dp/0262035820/ref=pd_[…]8b0679b4-6608-4773-94a5-4e68366fbaed&pd_rd_i=0262035820&psc=1 Dr. Cernera also provided several documents that can be helpful for your graduate school and postdoctoral studies applications. The links to these documents will be provided here later. About the Podcast Host: The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a neuroscience educator, research consultant, and career coach for people in neuroscience and neurotechnologies. As a professional coach with a background in the field, Dr. K understands the unique challenges and opportunities job applicants face in this field and can provide personalized coaching and support to help you succeed. Here's what you'll get with one-on-one coaching sessions from Dr. K: Identification and pursuit of career goals Guidance on job search strategies, resume and cover letter development, and interview preparation Access to a network of professionals in the field of neuroscience and neurotechnologies Ongoing support and guidance to help you stay on track and achieve your goals You can always schedule a free neurocareer consultation/coaching session with Dr. K at https://neuroapproaches.as.me/free-neurocareer-consultation Subscribe to our Nerocareers Newsletter to stay on top of all our cool neurocareers news at updates https://www.neuroapproaches.org/neurocareers-news
March 2024 Journal Club Podcast Title: Neurological Surgery Residency Programs in the United States: A National Cross-Sectional Survey To read journal article: https://journals.lww.com/neurosurgery/fulltext/2024/03000/neurological_surgery_residency_programs_in_the.12.aspx Senior Author: Brian Nahed Guest faculty: Robert Harbaugh Resident Planner: Alex Suarez Moderator: Kimberly Hoang
In this episode of the Healthy, Wealthy, and Smart podcast, host Dr. Karen Litzy welcomes Dr. Jeffrey Gross, founder of ReCELLebrate and a pioneer in the field of regenerative medicine. They discuss the concept of regenerative medicine, stem cell treatments, and their applications in healthcare. Dr. Gross shares his journey from being a neurosurgeon to exploring regenerative medicine and how it allows him to tap back into his undergraduate background in biochemistry and molecular cell biology. He highlights the need for innovation in the medical field and the potential of regenerative medicine to revolutionize healthcare practices. Tune in to learn more about this exciting field and its possibilities for improving patient outcomes. Show notes: [00:03:21] Stem cell treatments. [00:04:16] What are stem cells? [00:09:17] Regenerative medicine and joint problems. [00:14:04] Regenerative medicine for joint replacement. [00:18:17] Surgery and its necessity. [00:24:31-00:24:41] Biohacking and its benefits. [00:30:08] Trusting regenerative medicine doctors. [00:33:28] Expanding clinic with satellite. More About Dr. Gross: Dr. Gross graduated from the University of California, Berkeley with a degree in biochemistry and molecular cell biology. He earned his Doctor of Medicine in 1992 from the George Washington University School of Medicine. He contributed to virology research during his studies. After graduating, he undertook a residency in neurological surgery at the University of California, Irvine Medical Center until 1997. He then pursued a Fellowship in Spinal Biomechanics at the University of New Mexico until 1999. Licensed in California and Nevada, Dr. Gross has SPINE practices in Orange County and Henderson, Nevada. A trained neurological surgeon, he specializes in athletic injuries and spine procedures, and offers longevity and biohacking consultations. He's certified by the American Board of Neurological Surgery and is a member of several prestigious surgical societies. Since 2020, Top Doctor recognized Dr. Gross as a leading Neurological Surgeon. He also received HealthTap's 2022 Top Doctor Award as a top Neurological Surgeon in the U.S. Dr. Gross founded ReCELLebrate, focusing on anti-aging and regenerative medicine. The mission for ReCELLebrate emphasizes offering modern biochemical treatments and considering surgery as a last resort. Resources from this Episode: ReCELLebrate Website Dr. Gross on LinkedIn ReCELLebrate TikTok ReCELLebrate Instagram Dr. Gross YouTube Jane Sponsorship Information: Book a one-on-one demo here Mention the code LITZY1MO for a free month Follow Dr. Karen Litzy on Social Media: Karen's Twitter Karen's Instagram Karen's LinkedIn Subscribe to Healthy, Wealthy & Smart: YouTube Website Apple Podcast Spotify SoundCloud Stitcher iHeart Radio
Dr. Gabrielle Morris is the Chief Medical Officer of Duber Medical, a leader in medical cannabis doctor consultations with a mission to educate patients on the medical benefits of cannabis. Dr. Morris brings her more than 30 years medical experience to a unique medical cannabis practice. Duber Medical is a physician and woman-owned practice that works with a diverse population of more than 10,000 patients across eleven states, collecting real data on the clinical benefits of medical cannabis.Dr. Morris is certified by the National Board of Neurological Surgeons. Her career spans a myriad of specialties including Neurological Surgery, Trauma, Complex Orthopedic Spinal Surgery, and Emergency Medicine.Dr. Morris has been a long-time proponent of medical cannabis and was an early supporter of California's Proposition 215, which first legalized medical marijuana treatment for patients in 1996. On today's show she shares with Joyce how her work at a local trauma center led to her understanding that medical cannabis is a viable and beneficial treatment option for many patients who seek to improve their quality of life.Joyce also speaks with Nurse Lisa Capitani about her Mindful Metrics: Conscious Cannabis Consumption Tracking Journal, now available on Amazon. This journal is designed for both the seasoned cannabis user and those just beginning their exploration, to optimize the therapeutic potential of cannabis.Culture Corner: Joyce recommends a mini-series that documents the Charles Stuart case - 1989 murder of his pregnant wife and uses it to tell a story about racism in Boston – it's called Murder in Boston.Topics Discussed(1:08) Welcome(3:05) Connect with Tia Moskalenko(3:44) Lisa Capitani, Tracking Journal(4:20) Culture Corner: Murder in Boston(8:14) The Hemp Guitar(9:05) Dr. Gabrielle Morris Intro(10:37) Epiphany at ER(15:21) Audio Intro(17:40) Patient Range(21:50) Patient Stories(22:48) Women Blooming on Cannabis(24:37) Feeling Again(25:03) Motherhood and Cannabis(29:35) Lisa Capitani – Journal(37:15) Lisa's Canna Journey(39:25) Connect with Lisa on Website or Instagram(40:28) Happy Medicine(42:40) Individualized Medicine(45:50) Duber Medical Website and YouTube(47:30) Still Fighting Stigma in 2024(49:35) Dubermedical.com: code DUBERMED The Canna Mom Show wants to thank:Josh Lamkin and Bella Jaffe for writing and performing TCMS theme music and Fortuna Design for creating TCMS website.
Dr. Roger Hartl, Professor of Neurological Surgery and Director of Spinal Surgery at the Weill Cornell Medicine Brain and Spine Center provides a glimpse into his journey, offers insights into his expertise in neurological surgery, developments in his field, and trends shaping the industry as we approach 2024. He delves into his mission work in Tanzania, discussing his proudest achievements and providing guidance for other surgeons eager to contribute to a cause.
Dr. Roger Hartl, Professor of Neurological Surgery and Director of Spinal Surgery at the Weill Cornell Medicine Brain and Spine Center provides a glimpse into his journey, offers insights into his expertise in neurological surgery, developments in his field, and trends shaping the industry as we approach 2024. He delves into his mission work in Tanzania, discussing his proudest achievements and providing guidance for other surgeons eager to contribute to a cause.
This week on the Live to Walk Again Podcast we had the pleasure of doing a roundtable discussion with amateur neuroscientist, Spinal Cord Injury Survivor, and retired firefighter Devon Colbert along with Dr. David W McMillan who is a Research Assistant Prof. in the Department of Neurological Surgery at the University of Miami and the Dir. of Education and Outreach at The Miami Project to Cure Paralysis. In this episode we briefly discussed Devon's experimentation with psilocybin in hopes of finding a useful treatment to help in restoring function after spinal cord injury, the research studies he's been working on since he was last on the podcast, and some related studies that Dr. McMillan has worked on. We also chatted about some of the dangers of using psychedelics after a spinal cord injury including spasms and the potential to overheat your body's core temperature. Connect with Devin and Dr. McMillan at their Instagram links below!! Please listen, like, rate, review, and share the podcast!! We're just trying to find a cure for paralysis!! Devin Colbert: IG: @colbert76 Dr. David W McMillan: IG: @mkysml
The CE experience for this Podcast is powered by CMEfy - click here to reflect and earn credits: https://earnc.me/O9a1Y4 Jay Wellons MD, MSPH holds the Cal Turner Chair of Pediatric Neurosurgery and is Chief of the Division of Pediatric Neurosurgery at Vanderbilt University Medical Center (VUMC) and the Monroe Carell Jr. Children's Hospital at Vanderbilt. He is a Professor in the Departments of Neurological Surgery, Pediatrics, Plastic Surgery, and Radiology and Radiological Sciences, and is also the Vice Chair of the Department of Neurosurgery. He founded SOCKS (the Surgical Outcomes Center for Kids) in 2015 and served as the Medical Director until 2022. He also served as the VUMC Section of Surgical Sciences Vice Chair of Clinical Research 2018-2022 and Department of Neurological Surgery Program Director for the Neurosurgery Residency Training Program from 2014-2018. In addition to his scientific writing, he has been a contributor to the New York Times Sunday Review, TIME, Garden and Gun Magazine, Fresh Air: NPR, and OprahDaily.com. His book All That Moves Us: A Pediatric Neurosurgeon, His Young Patients, and their Stories of Grace and Resilience with publisher Penguin Random House debuted in June of 2022. His non-scientific writing focuses specifically on his specialty of pediatric neurosurgery, but also the broader field of medicine and the profound lessons learned from the children and parents that he has cared for over the last 30 years. -+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+=-+= This Episode is brought to you today by Eagle Financial Group. Eagle Financial Group is here to help you understand your numbers to make wise decisions. From fractional CFO services to accounting, bookkeeping, and payroll, Eagle financial group is your partner to ensure that your practice keeps on serving your patients, and gives you more time to spend with your family and friends. It's time that you overcome your obstacles, and get control of your financial life today. Give Eagle Financial Group a call at 719-755-0043, drop us an email at clientservices@eaglefsg.com, or visit us on line at eaglefsg.com We are a proud sponsor of the MD Coaches family of podcasts. -=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=- Are you a doctor struggling to provide the best care for your patients while dealing with financial and caregiving matters out of the scope of your practice? Do you find yourself scrambling to keep up with the latest resources and wish there was an easier way? Finally, our Virtual Health and Financial Conference for Caregivers is here! This conference helps you and your patients enlist the best strategies around health care resources and the best financial steps for your patients to take while navigating care. You don't have to go home feeling frustrated and helpless because you couldn't connect your patients with the best services. In just 90 minutes, our VIP Live Roundtable will answer your questions and be the lifeline that helps your patients put together an effective caregiving plan. Find out more at Jeanniedougherty.com and click on Conference for Caregivers VIP. -=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=-=+=- Join the Conversation! We want to hear from you! Do you have additional thoughts about today's topic? Do you have your own Prescription for Success? Record a message on Speakpipe Unlock Bonus content and get the shows early on our Patreon Follow us or Subscribe: Apple Podcasts | Google Podcasts | Stitcher | Amazon | Spotify --- Show notes at https://rxforsuccesspodcast.com/172 Report-out with comments or feedback at https://rxforsuccesspodcast.com/report Music by Ryan Jones. Find Ryan on Instagram at _ryjones_, Contact Ryan at ryjonesofficial@gmail.com Production assistance by Clawson Solutions Group, find them on the web at csolgroup.com
THIS EPISODE OF GROWING OLDER LIVING YOUNGER focuses on application of stem cells and other regenerative practices as alternatives to early use of spinal surgery Today's Featured Expert is Dr. Jeffrey Gross, neurosurgeon and regenerative medicine practitioner. Dr. Gross, graduated from the University of California Berkeley with a degree in biochemistry and molecular cell biology. He earned his Doctor of Medicine in 1992 from the George Washington University School of Medicine, contributing to virology research during his studies. His residency in neurological surgery at the University of California, Irvine Medical Center, was followed by a fellowship in spinal biomechanics at the University of New Mexico. Dr. Gross has Spine practices in Orange County, and Henderson, Nevada. He specializes in athletic injuries and spine procedures, and offers longevity and bio hacking consultations. Certified by the American Board of Neurological Surgery, Dr. Gross is recognized as a leading neurological surgeon. He founded Recellebrate, focusing on anti aging and regenerative medicine to emphasize modern biochemical treatments, considering surgery as a last resort. Episode Timeline 0.11 Introduction to regenerative stem cell technology and spinal surgery alternatives. 4:18 The switch from spinal neurosurgery focus to regenerative medicine. 8:52 Spinal surgery - outcomes and risks 15:59 Sciatica, stem cells and regenerative medicine 22:29 Immune reactions in stem cells and transplants 37:19 Aging, health, and regenerative medicine. About this episode's Featured Expert: Dr. Jeffrey Gross https://recellebrate.com/ https://www.instagram.com/recellebrate/ https://www.youtube.com/@stemcellwhisperer https://www.linkedin.com/in/jeffrey-gross-md-5605605/ Contact Your Host: Dr. Gillian Lockitch Download your free Guide to Living Younger Longer. Schedule a free Discovery Call with Dr. Gill NEW: Download the Growing Older Living Younger app (Apple or Android) About Your Host: Dr. Gillian Lockitch Email Dr. Gill at askdrgill@gmail.com website: https://www.askdrgill.com/ Facebook: https://www.facebook.com/gillian.lockitch/ GOLY Community: https://www.facebook.com/groups/growingolderlivingyounger And if you have not already done so, please follow, rate and review the Growing Older Living Younger podcast
About The Guest: - Dr. Kyle J. Godfrey is an assistant professor in the Departments of Ophthalmology and Neurological Surgery and the Ophthalmology Residency Program Director at Wild Cornell Medicine and New York Presbyterian Hospital in New York, New York. - Dr. Evan Kalin-Hajdu is an assistant professor at the University of Montreal and a member of the department of Ophthalmology at Maisonneuve-Rosemont and Ste. Justine hospitals in Montreal, Quebec. - Dr. Amina Malik is the director of Ophthalmic Plastic and Reconstructive Surgery and an associate professor at the Blanton Eye Institute at Houston Methodist Hospital. She also has a joint appointment in the Department of Otolaryngology at Houston Methodist and an academic affiliation at Texas A&M and Wild Cornell Medicine. - Dr. Gary Lelli is the vice Chair of Ophthalmology, Director of Ophthalmic Plastic and Reconstructive Surgery, and an associate professor at Wild Cornell Medicine and New York Presbyterian Hospital in New York, New York. Summary: Dr. Kyle Godfrey hosts a discussion with Dr. Evan Kalin-Hajdu, Dr. Amina Malik, and Dr. Gary Lelli about three selected articles from the current issue of OPRS Journal. The first article discusses the predictability of the phenylephrine test in congenital ptosis, the second article evaluates the incidence and risk factors for poor postoperative visual outcomes after excision of orbital cavernous venous malformations, and the third article presents a surgical technique for reconstructing large full-thickness lower eyelid defects. The experts provide their insights and opinions on the articles, discussing the findings, limitations, and potential implications for clinical practice. Key Takeaways: - MMCR is a viable option for moderate levator function congenital ptosis, and the phenylephrine response appears to be the most valuable predictor of surgical outcome. - Surgical excision of orbital cavernous venous malformations carries a risk of vision loss, and the incidence and risk factors for poor postoperative visual outcomes should be carefully considered. - The reconstruction of large full-thickness lower eyelid defects can be achieved using remnant eyelid rotation, semicircular skin and muscle flaps, and lateral tarsoconjunctival flaps, providing good cosmetic outcomes and avoiding the need for a second stage reconstruction. If you're an ASOPRS Member, Surgeon or Trainee and are interesting in hosting a podcast episode, please submit your idea by visiting: asoprs.memberclicks.net/podcast
Chronic back or joint pain and looking for non-surgical pain relief? Recent injury that you want to heal up quicky? Wanting to look and feel amazing and wondering how you can take your health to the next level? Curious about the regenerative effects of stem cell therapy, exosomes and peptides? Dr. Jeffrey Gross, MD is a neurological surgeon specilizing in athletic injuries and spine procedures, in addition to longevity and biohacking therapies. He's certified by the American Board of Neurological Surgery and is a member of several prestigious surgical societies. Since 2020, Top Doctor recognized Dr. Gross as a leading Neurological Surgeon. He also received HealthTap's 2022 Top Doctor Award as a top Neurological Surgeon in the U.S. Dr. Gross founded ReCELLebrate to focus on anti-aging and regenerative medicine. In this episode of The Health Fix Podcast, Dr. Jannine Krause interviews Dr. Jeffrey Gross on how he's using modern biochemical treatments to help folks looking to improve their longevity and vitality as well as for those interested in non-surgical options for chronic pain and injuries. What You'll Learn In This Episode: How stem cell therapy gives your body information to restore & repair Why you need healthy stem cells for best effect & how they are being harvested What you can do to activate your own healthy stem cells How stem cells are paired with regenerative biologics like PRP (platelet rich plasma) for rejuvenation Why stem cells from fat tissue aren't the best option for repair and regeneration How exosomes are being used to activate stem cells and boost cell communication and enhance rejuvenation What it looks like to use exosomes, IV therapy and stem cells for longevity How targeting bones helps the body restore cartilage in joints The connection between bone density and longevity Advances in dry eye syndrome Investments for regenerative therapies Resources From The Show: Dr. Gross's Website - ReCELLebrate - https://recellebrate.com/ Mention The Health Fix Podcast and for a complimentary consult ReCELLebrate on Instagram
ReCELLebrate The Power of Anti-Aging and Regenerative Medicine with Dr. Jeffrey Gross Hello beautiful humans, thank you for listening and supporting the Thrive Forever Fit Show. It truly means the world to me that you take time out of your precious day to listen to me ramble and rant about things I found entertaining, engaging, and meaningful. Show Sponsor: SpaStar www.spastar.net The Get Ready Wrap™ is spa-inspired and made for virtually every body. Designed with comfort and eco-elegance in mind - no velcro, snaps, or bulky material that take up too much room in your closet, laundry, or suitcase. This luxury spa wrap is perfect for spa treatments, beauty rituals, special occasions, getting ready, makeup tutorials, travel, by the pool, and the gym bag.Discount Code to Save 15% Off Your Get Ready Wrap: THRIVE15 “ReCELLebrate” The Power of Anti-Aging and Regenerative Medicine with Dr. Jeffrey Gross Dr. Gross graduated from the University of California, Berkeley with a degree in biochemistry and molecular cell biology. He earned his Doctor of Medicine in 1992 from the George Washington University School of Medicine. He contributed to virology research during his studies. After graduating, he undertook a residency in neurological surgery at the University of California, Irvine Medical Center until 1997. He then pursued a Fellowship in Spinal Biomechanics at the University of New Mexico until 1999. Licensed in California and Nevada, Dr. Gross has SPINE practices in Orange County and Henderson, Nevada. A trained neurological surgeon, he specializes in athletic injuries and spine procedures, and offers longevity and biohacking consultations. He's certified by the American Board of Neurological Surgery and is a member of several prestigious surgical societies. Since 2020, Top Doctor recognized Dr. Gross as a leading Neurological Surgeon. He also received HealthTap's 2022 Top Doctor Award as a top Neurological Surgeon in the U.S. Dr. Gross founded ReCELLebrate, focusing on anti-aging and regenerative medicine. The mission for ReCELLebrate emphasizes offering modern biochemical treatments and considering surgery as a last resort. Social Media Links and Website: Website: https://recellebrate.com/ IG: https://www.instagram.com/recellebrate/ TT: https://www.tiktok.com/@recellebrate LinkedIn: https://www.linkedin.com/in/jeffrey-gross-md-5605605/ YouTube: https://www.youtube.com/@stemcellwhisperer Mission of the conversation: To discuss the transformative potential of regenerative medicine guiding the audience on how to prolong and enhance the quality of their health span with stem cells while emphasizing the significance of ensuring that our quality of health matches our years. Stay tuned for our upcoming episodes, where we'll continue to explore themes that inspire personal development and positive change. You are capable, and your journey matters. If you love the show, it would mean the world to me if you'd like it, share it, and review it. That's the only way I can help more people and continue to fulfill my mission of helping others overcome pain and start living a life of peaceful passion. Links: Thrive Forever Fit Supplements Thrive Forever Fit Coaching Program Thrive Fitness Studio FREE Facebook Group: Wellness Lab Best Selling Books: The Overweight Mind The Purpose of Pain
The Fat-Burning Man Show by Abel James: The Future of Health & Performance
How is it possible to shed over 100 pounds and keep it off without exercise? How can we counteract the damaging effects of artificial blue light and non-native EMF to heal at the cellular level? Why are professional athletes suddenly falling apart in their prime, and what can we do about it? To answer these questions and more, I'm honored to welcome back to the show, our friend Dr. Jack Kruse, a respected neurosurgeon, CEO of the Kruse Longevity Center, author, self-described mitochondriac, and inventor looking at the quantum level to explain how nature works in biology. Dr. Kruse is board-certified by the American Board of Neurological Surgery and has completed more than 10,000 surgeries in his career. For the edification of those who don't know him. Dr. Jack Kruse is an incredible, brilliant human being. He's been known to write blog posts buck naked outside in below-freezing temperatures, pack himself on ice for hours and get banned from TED talks. Back in 2008, Dr. Kruse began experimenting on himself with various protocols including leptin and cold thermogenesis, and as a result shed an astounding 133+ pounds without focusing on exercise. Dr. Kruse is a fearless seeker ready to blow the top off the centralized paradigm to uncover the whole truth, and he holds no punches in today's interview, as usual. In this interview with Dr. Jack Kruse, we're chatting about: The truth about how humans can optimize function within the laws of nature (hint: light, water and magnetism) How to break free from the centralized paradigm in medicine and its centralized profiteers A quick history of medical tyranny in the United States How to use UV light and cold temperatures to access the superhuman pathway How to harness the power of the sun and melanin to fuel your mitochondria How to counteract the damaging effects of non-native EMFs Why using Bluetooth headphones is like microwaving your brain Why we should rewild and get outdoors while exercising And tons more… Buckle up ladies and gentlemen, here is the much anticipated interview with the one and only, Dr. Jack Kruse. I hope you enjoy. Read the show notes: https://fatburningman.com/dr-jack-kruse-circadian-biology-melanin-how-to-heal-your-mitochondria/ Head over to JackKruse.com for mind-expanding blogs, join the discussion on the forum, get books, webinars and much more. Join The Wild Guild and get freebies on Patreon: https://www.patreon.com/abeljames Like the show on Facebook: http://www.facebook.com/fatburningman Follow me on Twitter: http://www.twitter.com/fatburnman Click here for your free Fat-Burning Kit: http://fatburningman.com/bonus
Fat-Burning Man by Abel James (Video Podcast): The Future of Health & Performance
How is it possible to shed over 100 pounds and keep it off without exercise? How can we counteract the damaging effects of artificial blue light and non-native EMF to heal at the cellular level? Why are professional athletes suddenly falling apart in their prime, and what can we do about it? To answer these questions and more, I'm honored to welcome back to the show, our friend Dr. Jack Kruse, a respected neurosurgeon, CEO of the Kruse Longevity Center, author, self-described mitochondriac, and inventor looking at the quantum level to explain how nature works in biology. Dr. Kruse is board-certified by the American Board of Neurological Surgery and has completed more than 10,000 surgeries in his career. For the edification of those who don't know him. Dr. Jack Kruse is an incredible, brilliant human being. He's been known to write blog posts buck naked outside in below-freezing temperatures, pack himself on ice for hours and get banned from TED talks. Back in 2008, Dr. Kruse began experimenting on himself with various protocols including leptin and cold thermogenesis, and as a result shed an astounding 133+ pounds without focusing on exercise. Dr. Kruse is a fearless seeker ready to blow the top off the centralized paradigm to uncover the whole truth, and he holds no punches in today's interview, as usual. In this interview with Dr. Jack Kruse, we're chatting about: The truth about how humans can optimize function within the laws of nature (hint: light, water and magnetism) How to break free from the centralized paradigm in medicine and its centralized profiteers A quick history of medical tyranny in the United States How to use UV light and cold temperatures to access the superhuman pathway How to harness the power of the sun and melanin to fuel your mitochondria How to counteract the damaging effects of non-native EMFs Why using Bluetooth headphones is like microwaving your brain Why we should rewild and get outdoors while exercising And tons more… Buckle up ladies and gentlemen, here is the much anticipated interview with the one and only, Dr. Jack Kruse. I hope you enjoy. Read the show notes: https://fatburningman.com/dr-jack-kruse-circadian-biology-melanin-how-to-heal-your-mitochondria/ Head over to JackKruse.com for mind-expanding blogs, join the discussion on the forum, get books, webinars and much more. Join The Wild Guild and get freebies on Patreon: https://www.patreon.com/abeljames Like the show on Facebook: http://www.facebook.com/fatburningman Follow me on Twitter: http://www.twitter.com/fatburnman Click here for your free Fat-Burning Kit: http://fatburningman.com/bonus
Fat-Burning Man by Abel James (Video Podcast): The Future of Health & Performance
How is it possible to shed over 100 pounds and keep it off without exercise? How can we counteract the damaging effects of artificial blue light and non-native EMF to heal at the cellular level? Why are professional athletes suddenly falling apart in their prime, and what can we do about it? To answer these questions and more, I'm honored to welcome back to the show, our friend Dr. Jack Kruse, a respected neurosurgeon, CEO of the Kruse Longevity Center, author, self-described mitochondriac, and inventor looking at the quantum level to explain how nature works in biology. Dr. Kruse is board-certified by the American Board of Neurological Surgery and has completed more than 10,000 surgeries in his career. For the edification of those who don't know him. Dr. Jack Kruse is an incredible, brilliant human being. He's been known to write blog posts buck naked outside in below-freezing temperatures, pack himself on ice for hours and get banned from TED talks. Back in 2008, Dr. Kruse began experimenting on himself with various protocols including leptin and cold thermogenesis, and as a result shed an astounding 133+ pounds without focusing on exercise. Dr. Kruse is a fearless seeker ready to blow the top off the centralized paradigm to uncover the whole truth, and he holds no punches in today's interview, as usual. In this interview with Dr. Jack Kruse, we're chatting about: The truth about how humans can optimize function within the laws of nature (hint: light, water and magnetism) How to break free from the centralized paradigm in medicine and its centralized profiteers A quick history of medical tyranny in the United States How to use UV light and cold temperatures to access the superhuman pathway How to harness the power of the sun and melanin to fuel your mitochondria How to counteract the damaging effects of non-native EMFs Why using Bluetooth headphones is like microwaving your brain Why we should rewild and get outdoors while exercising And tons more… Buckle up ladies and gentlemen, here is the much anticipated interview with the one and only, Dr. Jack Kruse. I hope you enjoy. Read the show notes: https://fatburningman.com/dr-jack-kruse-circadian-biology-melanin-how-to-heal-your-mitochondria/ Head over to JackKruse.com for mind-expanding blogs, join the discussion on the forum, get books, webinars and much more. Join The Wild Guild and get freebies on Patreon: https://www.patreon.com/abeljames Like the show on Facebook: http://www.facebook.com/fatburningman Follow me on Twitter: http://www.twitter.com/fatburnman Click here for your free Fat-Burning Kit: http://fatburningman.com/bonus
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