Podcasts about Synaptic

Are you ready to revolutionize your Credit Union with cutting-edge AI? How can Pankaj Jain's expertise in technology and entrepreneurship transform your digital lending?Welcome to Credit Union Conversations, where we unpack the future of finance with industry trailblazers. Join host Mark Ritter as he dives deep with Pankaj Jain, exploring AI innovations from Synaptic to Algebrik, building trust amid legacy systems, and overcoming fear through continuous learning to attract Gen Z credit union members. Pankaj Jain, a serial entrepreneur whose journey from India to the heart of New York has fueled game-changing tech for credit unions, shares insights on innovation, relationship-building, and staying ahead in a rapidly evolving world. Whether you're navigating digital transformation or seeking growth strategies, this episode is packed with actionable wisdom. Let's dive in!IN THIS EPISODE:(00:00) Intro: Meet Pankaj(03:13) Pankaj describes his early entrepreneurship and his drive for Technology(04:57) Pankaj recounts moving to New York and pivoting Synaptic to serve Credit Unions(08:10) Algebrik, started in August 2024, to build Digital ecosystems for Credit Unions(13:50) Pankaj shares what he has learned over the years and emphasizes Trust as key in Credit Unions, built through consistent engagement(19:27) Reflecting on AI discussions in 2014, before ChatGPT, facing cynicism but building credibility for Synaptic's technology (29:14) Pankaj advocates digital tools to attract younger generations to the credit unions(34:35) Pankaj stresses the democratization of AI Technology to avoid mergers and maintain charters (39:55) Pankaj suggests the importance of education and learning about current and future technologyKEY TAKEAWAYS:AI and digital technology are critical for credit unions to modernize lending, reduce reliance on legacy systems, and attract younger members by meeting them on mobile platforms with seamless, paperless processes.Building trust through consistent, personal engagement is essential for entrepreneurship in the credit union space, as Pankaj Jain demonstrates with Synaptic and Algebrik, emphasizing relationships over transactional sales.Overcoming the fear of change through continuous learning enables credit unions to adopt AI solutions, as Pankaj Jain advocates, ensuring that smaller institutions can compete and grow without merging, thereby preserving their mission and charter.RESOURCE LINKS:Mark Ritter - WebsiteMark Ritter - LinkedInPankaj Jain - LinkedInAlgebrik AI - WebsitePankaj LD Jain - WebsiteContact PankajBIOGRAPHIES:PJ is the Founder and CEO of Algebrik. Algebrik, headquartered in New York City, is the world's 1st cloud-native, AI-powered digital-era Loan Origination Platform (LOS), designed for the next generation of members/consumers.KEYWORDS: AI, Credit Unions, Pankaj Jain, Technology, Entrepreneurship, Travel, New York, Synaptic, Algebrik, Digital, Lending, Members, Trust, Legacy, Systems, Fear, Learning, Loan Originating Platform, LOS

New episode of Synaptic Rhythms bringing you into ecstacy with Mystic sounds and Deep melodies!

The best progressive show returns with some of the most beautiful and uplifting tracks out there mixed to energize the crowd and keep the fire warm your souls! Don't forget to follow me every sunday night at 23:00 CET where the whole series is played on the Spanish radio station www.planetmusic.es Much love DJLOTECK

Brand new Synaptic Rhythms Holiday episode with the most beautiful melodies and flows altering your mindset to a positive vibe!!

In this comprehensive deep dive, Dr. Tony Ebel explores groundbreaking research on decreased synaptic density in autism and reveals why the answers to autism don't lie in the brain alone. Drawing from a Princeton/Harvard study using PET scans, Dr. Ebel explains how autism actually begins in the body's neuromotor system and manifests in the brain. He breaks down complex neurological concepts into understandable terms, explaining the three-step nervous system process (input, integration, output) and introducing critical terms like subluxation, dyskinesia, and dysafferentation. This episode challenges the traditional medical approach to autism and presents a revolutionary understanding of how Neurologically-Focused Chiropractic Care can stimulate neuroplasticity and build the missing synaptic bridges in autistic brains. Dr. Ebel emphasizes that proprioceptive input from movement and spinal adjustments is more foundational to brain function than gut health or supplements, offering hope for families seeking root-cause healing.Key Topics & Timestamps([00:04:00]) - The Perfect Storm Promise - Dr. Ebel's commitment to connecting dots and simplifying complex autism research([00:07:00]) - "Autism Doesn't Begin in the Brain" - Introduction to the revolutionary concept and research limitations([00:20:00]) - 17% Synaptic Density Decrease - What the study found in autism brains and affected regions([00:24:00]) - The Seven Senses and Perfect Storm - Why movement and proprioception are key, not just the five basic senses([00:27:00]) - Three-Step Nervous System Process - Afferentation (input), integration, and efferentation (output)([00:31:00]) - Subluxation and Dysafferentation - How birth trauma disrupts nervous system input([00:37:00]) - Why Kids with Autism Crave Input - Understanding stimming, weighted blankets, and proprioceptive needs([00:39:00]) - Chiropractic's Unique Power - Why neurologically-focused adjustments outperform supplementsResearch Study Referenced in this Episode-- Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!

Synaptic plasticity underlies several key brain functions including learning, information filtering and homeostatic regulation of overall neural activity. While several mathematical rules have been developed for plasticity both at excitatory and inhibitory synapses, it has been difficult to make such rules co-exist in network models.  Recently the group of the guest has explored how co-dependent plasticity rules can remedy the situation and, for example, assure that long-term memories can be stored in excitatory synapses while inhibitory synapses assure long-term stability.

pt.20 of the best show in town real music real mixing real high!! Enjoy partypeople!!

Back with another psychedelic episode of Synaptic Rhythms bringing you the finest in Organic, Melodic Progressive music taking you into a state of inner peace and tranquility. Enjoy!!

     This week- two films featuring men abusing their positions of power and the fallout from it.     Miss Giddens is hired as a governess at Bly Manor. She is immediately taken with her young charge, Flora, and strikes an instant friendship with Mrs. Grose, the housekeeper. Despite the encouraging start, small moments of discomfort begin to poke at Miss Giddens new normal. When Miles is expelled from his boarding school, Miss Giddens finds herself caught up in the effects from the not too distant past. Based on one of the most influential horror tales ever written with a screenplay co-written by Truman Capote, taking a three week break from his magnum opus to work on it, and casting its own shadow nearly as long for itself- The Innocents.     Lillian founds a ballet company in the name of her late husband. Her ambulance-chasing attorney, Roland T. Flakfizer- assisted by associated   Rocco and Jacques, face off against the late husband's equally conniving lawyer, Edmundo Lazlo. The legal eagles compete to sign the world's greatest ballet dancer, "The Great" Volare, and to deliver an awe-inspiring Broadway debut for the new company. Inspired by the Marx Brothers, even being filmed at the same locations as several of their most beloved films, produced by David and Jerry Zucker, and fully embracing the "they don't make them like they used to" lifestyle- Brain Donors.     All that and Kevin enthuses, Dave forgot, and Tyler weeps in his Happy Place. Join us, won't you?   Episode 416- Synaptic Rotation

Streamlining the problem from 3D to 1D eases the expedition—a strategy the study investigators deployed to rewire an olfactory circuit in flies.

To start the weekend chilled with some drinks and your feet on the dancefloor acompanied by a smooth atmosperic sound along an ever beating drum you know its time to enjoy with Synaptic Rhythms coming from your speakers.. LOTECK

A mix of Beautiful sounds with Progressive, Organic and Melodic tones bringing your mind and body in ecstacy floating through atmospheric hights and tribal beats!!

What are we sleeping less and less? What are the benefits of getting a good nights sleep and the risks if we consistently don't? How is sleep linked to memory, cognitive performance, blood sugar regulation & stress hormones? How is young people's development affected by sleep?In this episode we have the surprising data on the science of sleep to get up to date on; so, why there's a sleep deprivation epidemic; how sleep works and what it's required for; dreams; and importance of sleep for learning and for immunity. We're also going to discuss the wide range of serious health issues that arise with even a small sleep deficit, and the vast benefits of getting sleep right; and the lifestyle tips we need to consistently get the sleep we need. And of course, sleep and mental health, and the importance of sleep for development in young people.Gratefully our guest today is a psychologist and neuroscientist that specialises in sleep, mental health and dream research, particularly in young people. She's the Scientific Director of Psychology at the University of St. Thomas, Minnesota, Roxanne Prichard! She's the author of over 40 highly citied scientific papers, and her TEDx talk “Addressing our Childrens Sleep Debt” was featured in the lecture series: Transforming Education. She's quoted regularly in the press, inlcuding the New York Times, Wall Street Journal, Teen Vogue, and USA Today.What we discussed:00:00 Intro.05:00 The Sleep deprivation epidemic.07:15 Shaking off prejudice about resting being laziness. 08:31 Glymphatic system for toxin removal.10:00 Synaptic plasticity: Learning & unlearning.11:10 Learning & memory require sleep.14:00 The hippocampus processes memory during sleep.15:00 Late night cramming for exams blocks learning.15:50 Lack of sleep appears to the body as a threat out in the world.17:40 Blood sugar regulation is affected by sleep.18:00 “Sleep! Like diet and exercise only easier!”19:10 Immunity and sleep deprivation.21:00 Cancer & regularity of circadian rhythms.22:00 Evolution, daylight, circadian rhythms & learning.23:45 Sleep delay of morning stress hormones in teens. 26:15 Light Vs Deep ‘Slow Wave' Vs REM sleep.30:00 REM Sleep explained. 33:00 Dreams: The top theories.36:30 The electrical nature of sleep & brain waves.40:00 Alpha Waves and biofeedback for insomnia.42:00 Insomnia & the health risks of sleep deprivation.46:00 Sleep is within our control.47:15 The inflammation link with sleep.49:30 The mental health risks of sleep deprivation. 50:00 Catastrophising and attention deficit.50:45 College students mental health & sleep as a crucial marker.57:30 Persausive technology, screens & sleep.01:02:30 How much sleep do we need? 01:04:25 Avoid external stimulants & go to low light.01:06:00 Avoid internal stimulants like caffeine and alcohol. 01:07:40 Sleep and wake at regular times every day.01:08:40 Core temperature dropping signals sleep.01:10:00 Roxanne's campaign points.01:12:00 The shame around rest. References: Ya Chai at al, ‘Two nights of recovery sleep restores hippocampal connectivity but not episodic memory after total sleep deprivation' paper.https://www.nature.com/articles/s41598-020-65086-xN.I.H. article, 'Sleep on it - How snoozing strengthens memories' (40% drop in learning after sleep deprivation)https://newsinhealth.nih.gov/2013/04/sleep-itU. Chicago Medicine article, 'New study helps explain the link between sleep loss and diabetes'.Trisha Hershey, ‘the Nap' Bishop. - “Rest is Resistance” book.

UNETE AL DISCORD: https://discord.gg/6QueSttKdpTikTok: https://www.tiktok.com/@saunadelhypeInstagram: https://www.instagram.com/elsaunadelhypeSpotiffy: https://open.spotify.com/show/3UtPLiXC6M9b9qBuH8CauM?si=yUl1_eYvSHyAH9cWz44jxATwitter (X): https://x.com/ElSaunadelHypeBLOG: https://digitaldictator.blogspot.com/Facebook: https://www.facebook.com/elsaunadelhype/Colaboraciones: capitanhype666@gmail.com#deathmetal #synaptic #deathmetalmusic #metalmusic #melodicdeathmetal #obscura #technicaldeathmetal #podcast #reseñas

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: info.fromthespectrum@gmail.com

Spacing like never before in a 90 minute set taking you through all phases of the atmosphere!! njoy partypeople!!

Already part twelve of the series and we are keeping it floating through space and time creating that special atmosphere keeping you in psychedelic mode!!

O que acontece quando os mecanismos cerebrais que nos ajudam a sobreviver são sequestrados por substâncias ou comportamentos?  Neste episódio, o psiquiatra Gustavo Jesus e Rui Maria Pêgo exploram a ciência das adicções, relevando o que acontece no cérebro quando o prazer se transforma em vício.Nesta conversa, explica-se o funcionamento do «circuito da recompensa» e de que forma a dopamina e o glutamato criam hábitos que se tornam compulsões. Da tolerância à abstinência, esclarecem-se os critérios que definem uma verdadeira dependência e exploram-se dados preocupantes sobre consumos contemporâneos.Pelo caminho, desmistifica-se a canábis – muitas vezes vista como inofensiva, mas cujas variedades de alta potência têm aumentado casos de psicose – e fala-se sobre a ameaça crescente das apostas online, que já levaram quase 300 mil portugueses a pedir autoexclusão de plataformas de jogo.Sem esquecer o tema dos psicadélicos ou o papel-chave da comunidade na recuperação, este é um episódio que nos mostra como, numa sociedade de consumo e de gratificação imediata, compreender a neurobiologia das adições nos pode ajudar a combater tanto o estigma, como a dependência.REFERÊNCIAS E LINKS ÚTEISKAUER, Julie A. & MALENKA, Robert C., «Synaptic plasticity and addiction» (2007, Nature Publishing Group)MYRAN, D. T. et al., «Changes in Incident Schizophrenia Diagnoses Associated With Cannabis Use Disorder After Cannabis Legalization» (2025, JAMA Network Open)FELTENSTEIN, M. W., SEE, R. E., FUCHS, R. A., «Neural Substrates and Circuits of Drug Addiction» (2021, Cold Spring Harbor Perspectives in Medicine)CARAPINHA, Ludmila et al., «Comportamentos Aditivos aos 18 Anos: Inquérito aos Jovens Participantes no Dia da Defesa Nacional» (2022, Sicad)KELMENDI, B., KAYE, A. P., PITTENGER, C., KWAN, A. C., «Psychedelics» (2022, Current Biology)EMCDDA, «Understanding Europe's drug situation in 2024 – key developments» (2024, European Union Drugs Agency)CARAPINHA, Ludmila & LAVADO, «Emília, Consumo Problemático/Alto Risco» (2023, Sicad)BALSA, Casimiro et al., «V Inquérito Nacional ao Consumo de Substâncias Psicoativas na População Geral» (2022, Sicad)GRUPO ESPAD, «The European School Survey Project on Alcohol and Other Drugs» (2019, ESPAD GROUP)TORRES, Anália et al., «Inquérito Nacional sobre Comportamentos Aditivos em Meio Prisional» (2014, Sicad)Aplicação «I Am Sober»BIOSRUI MARIA PÊGOTem 35 anos, 16 deles passados entre a rádio, o teatro e a televisão.Licenciado em História pela Universidade Nova de Lisboa, e mestre em Fine Arts in Professional Acting pela Bristol Old Vic Theatre School.GUSTAVO JESUSMédico psiquiatra e trabalha há mais de 10 anos no PIN – Partners in Neuroscience. É atualmente diretor de Serviço no Hospital de Vila Franca de Xira, professor na Católica Medical School e membro da direção da SPPSM. Publicou artigos e trabalhos científicos, participou em livros técnicos e em muitas iniciativas de divulgação das neurociências clínicas, como forma de aumentar a informação e mitigar o estigma associado às doenças mentais.

Pinar Yoldas, Ph.D., an artist and professor at UC San Diego, uses her background in neuroscience and architecture to create thought-provoking art that blends biology, technology, and design. Her work imagines new possibilities for a more compassionate and sustainable future, from algae-based plastics to sculptures inspired by the human brain. By exploring how human desires drive technological innovation, Yoldas challenges us to consider how creativity can shape our world. Series: "Arts Channel " [Arts and Music] [Show ID: 39862]

Pinar Yoldas, Ph.D., an artist and professor at UC San Diego, uses her background in neuroscience and architecture to create thought-provoking art that blends biology, technology, and design. Her work imagines new possibilities for a more compassionate and sustainable future, from algae-based plastics to sculptures inspired by the human brain. By exploring how human desires drive technological innovation, Yoldas challenges us to consider how creativity can shape our world. Series: "Arts Channel " [Arts and Music] [Show ID: 39862]

Pinar Yoldas, Ph.D., an artist and professor at UC San Diego, uses her background in neuroscience and architecture to create thought-provoking art that blends biology, technology, and design. Her work imagines new possibilities for a more compassionate and sustainable future, from algae-based plastics to sculptures inspired by the human brain. By exploring how human desires drive technological innovation, Yoldas challenges us to consider how creativity can shape our world. Series: "Arts Channel " [Arts and Music] [Show ID: 39862]

Today on Double Tap, hosts Steven Scott and Shaun Preece chat about the challenges of smart home devices, and the issues Steven has had trying to connect smart devices on the move.Today's show is really all about you, as we dive into the inbox to hear listener emails discussing AI functionality in Meta Ray Bands, thoughts on the new Blindshell Classic 3, and the importance of community support in learning about new technology.Steven sets out his thoughts on the need for better education and resources for blind people who want to learn assistive and mainstream technology, while Shaun questions the public perceptions of blind people out there.Get in touch with Double Tap by emailing us feedback@doubletaponair.com or by call 1-877-803-4567 and leave us a voicemail. You can also now contact us via Whatsapp on 1-613-481-0144 or visit doubletaponair.com/whatsapp to connect. We are also across social media including X, Mastodon and Facebook. Double Tap is available daily on AMI-audio across Canada, on podcast worldwide and now on YouTube.Chapter Markers:00:00 Intro05:54 Smart Home Devices: Thermostats and Accessibility Issues11:56 Listener Feedback: AI and Meta Ray Bands20:59 Listener Feedback: Synapptic, BlindShell & Kapsys Smartphones40:52 Listener Feedback: Symbols and Their Significance52:25 Listener Feedback: Friendly Banter

….or at a podcast with at least an attempt at an explanation of what synaptic density is and how it is affected in brains of people with autism. This week we review three convergent lines of evidence – whole brain, brain cell then genes within those brain cells – that show that the autistic brain … Continue reading "Synaptic Density and Autism, explained"

In today's episode, we dive into the critical role of phospholipids in maintaining brain health, examining how these molecules contribute to neuronal communication, synaptic plasticity, and cognitive resilience. We'll explore the biochemical structure and function of key phospholipids like phosphatidylserine and phosphatidylcholine within neuronal membranes, where they play indispensable roles. We discuss associations and impacts of environmental toxins, aging, and neurodegenerative conditions. Finally, we discuss dietary tools to support phospholipid levels and promote cognitive health. Topics: 1. Introduction to Phospholipids and Cognitive Health 2. Brain Cell Structure and Composition - Neurons, glial cells. 3. Detailed Anatomy of Neurons - Soma contains organelles, dendrites receive signals, axon sends impulses. - Myelin sheath insulates axon, speeding signal transmission. - Myelin is rich in phospholipids. 4. Roles of Glial Cells in Brain Health - Astrocytes, oligodendrocytes, and microglia support neurons. - Glial cells regulate the brain's environment, form myelin, and provide immune defense. - Phospholipid-rich membranes are essential for glial function. 5. Biochemistry: Phospholipids - Phospholipids have a glycerol backbone, fatty acid tails, and a phosphate group. - Hydrophilic and hydrophobic parts form bilayers. - Key phospholipids: PC, PE, PS, PI 6. Phospholipid Bilayer's Role in Neuronal Communication - Ion channels, receptors, and transporters in the bilayer enable cell functions. - Ion channels allow ions to flow, creating signals for neuron communication. - Receptors detect neurotransmitters, initiating responses. 7. Neuronal Activation and Electrochemical Gradients - Resting neurons have ion concentration differences inside and outside the cell. - Ion channel activity during activation creates an action potential. - The phospholipid membrane enables controlled ion flow for signal transmission. 8. Neurotransmitter Release - Action potential at axon terminal triggers calcium entry. - Calcium causes vesicles to release neurotransmitters. - Released neurotransmitters bind to receptors, continuing the signal. 9. Diversity of Phospholipids in Neuronal Membranes - Different phospholipids (PC, PE, PS, PI) are essential for membrane integrity. 10. Summary: Phospholipids in Brain Function and Cognitive Health - Phospholipids support neuronal communication, synaptic plasticity, and cognitive resilience. - Synaptic plasticity - essential for learning and memory. 11. Phospholipid Disruption and Cognitive Decline - Oxidative stress, aging, and inflammation disrupt phospholipid composition. - Lipid peroxidation damages membranes, affecting neuron signaling. - Phospholipid damage contributes to cognitive decline. 12. Importance of Phospholipids in Aging and Brain Health - Lipid levels decrease with age, impacting brain function. 13. Environmental Toxins and the Brain - Heavy metals like mercury cause oxidative damage to phospholipids. - Damaged phospholipids and impaired neuron function. 14. Consequences of Suboptimal Phospholipids - Cognitive symptoms. - Low levels seen in neurodegenerative conditions. 15. Tools for Supporting Phospholipid Levels - Foods with PS and PC, such as fatty fish and eggs. - Phospholipid supplements. Thanks for tuning in! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Season 3 will begin next year.

Jay McClelland is a pioneer in the field of artificial intelligence and is a cognitive psychologist and professor at Stanford University in the psychology, linguistics, and computer science departments. Together with David Rumelhart, Jay published the two volume work Parallel Distributed Processing, which has led to the flourishing of the connectionist approach to understanding cognition. In this conversation, Jay gives us a crash course in how neurons and biological brains work. This sets the stage for how psychologists such as Jay, David Rumelhart, and Geoffrey Hinton historically approached the development of models of cognition and ultimately artificial intelligence. We also discuss alternative approaches to neural computation such as symbolic and neuroscientific ones. Patreon (bonus materials + video chat): https://www.patreon.com/timothynguyen Part I. Introduction 00:00 : Preview 01:10 : Cognitive psychology 07:14 : Interdisciplinary work and Jay's academic journey 12:39 : Context affects perception 13:05 : Chomsky and psycholinguists 8:03 : Technical outline Part II. The Brain 00:20:20 : Structure of neurons 00:25:26 : Action potentials 00:27:00 : Synaptic processes and neuron firing 00:29:18 : Inhibitory neurons 00:33:10 : Feedforward neural networks 00:34:57 : Visual system 00:39:46 : Various parts of the visual cortex 00:45:31 : Columnar organization in the cortex 00:47:04 : Colocation in artificial vs biological networks 00:53:03 : Sensory systems and brain maps Part III. Approaches to AI, PDP, and Learning Rules 01:12:35 : Chomsky, symbolic rules, universal grammar 01:28:28 : Neuroscience, Francis Crick, vision vs language 01:32:36 : Neuroscience = bottom up 01:37:20 : Jay's path to AI 01:43:51 : James Anderson 01:44:51 : Geoff Hinton 01:54:25 : Parallel Distributed Processing (PDP) 02:03:40 : McClelland & Rumelhart's reading model 02:31:25 : Theories of learning 02:35:52 : Hebbian learning 02:43:23 : Rumelhart's Delta rule 02:44:45 : Gradient descent 02:47:04 : Backpropagation 02:54:52 : Outro: Retrospective and looking ahead Image credits: http://timothynguyen.org/image-credits/ Further reading: Rumelhart, McClelland. Parallel Distributed Processing. McClelland, J. L. (2013). Integrating probabilistic models of perception and interactive neural networks: A historical and tutorial review   Twitter: @iamtimnguyen   Webpage: http://www.timothynguyen.org

Dissuaded from pursuing theoretical physics and deterred by the “long feedback loop” in experimental physics, the National Academy of Sciences member took inspiration from “polymath” Watt Webb and “visionary” Stephen Smith—and learned to work “completely outside his comfort zone.”

Support the show to get full episodes and join the Discord community. https://youtu.be/lbKEOdbeqHo The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. The Transmitter has provided a transcript for this episode. Vijay Namoodiri runs the Nam Lab at the University of California San Francisco, and Ali Mojebi is an assistant professor at the University of Wisconsin-Madison. Ali as been on the podcast before a few times, and he's interested in how neuromodulators like dopamine affect our cognition. And it was Ali who pointed me to Vijay, because of some recent work Vijay has done reassessing how dopamine might function differently than what has become the classic story of dopamine's function as it pertains to learning. The classic story is that dopamine is related to reward prediction errors. That is, dopamine is modulated when you expect reward and don't get it, and/or when you don't expect reward but do get it. Vijay calls this a "prospective" account of dopamine function, since it requires an animal to look into the future to expect a reward. Vijay has shown, however, that a retrospective account of dopamine might better explain lots of know behavioral data. This retrospective account links dopamine to how we understand causes and effects in our ongoing behavior. So in this episode, Vijay gives us a history lesson about dopamine, his newer story and why it has caused a bit of controversy, and how all of this came to be. I happened to be looking at the Transmitter the other day, after I recorded this episode, and low and behold, there was an article titles Reconstructing dopamine's link to reward. Vijay is featured in the article among a handful of other thoughtful researchers who share their work and ideas about this very topic. Vijay wrote his own piece as well: Dopamine and the need for alternative theories. So check out those articles for more views on how the field is reconsidering how dopamine works. Nam Lab. Mohebi & Associates (Ali's Lab). Twitter: @vijay_mkn @mohebial Transmitter Dopamine and the need for alternative theories. Reconstructing dopamine's link to reward. Related papers Mesolimbic dopamine release conveys causal associations. Mesostriatal dopamine is sensitive to changes in specific cue-reward contingencies. What is the state space of the world for real animals? The learning of prospective and retrospective cognitive maps within neural circuits Further reading (Ali's paper): Dopamine transients follow a striatal gradient of reward time horizons. Ali listed a bunch of work on local modulation of DA release: Local control of striatal dopamine release. Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers. Spatial and temporal scales of dopamine transmission. Striatal dopamine neurotransmission: Regulation of release and uptake. Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons. An action potential initiation mechanism in distal axons for the control of dopamine release. Read the transcript, produced by The Transmitter. 0:00 - Intro 3:42 - Dopamine: the history of theories 32:54 - Importance of learning and behavior studies 39:12 - Dopamine and causality 1:06:45 - Controversy over Vijay's findings

In this week's very special episode Nick interviews Justin Moore, a long time War Room member. Just in fresh off the back of amazing first place victory at the Texas Open with his Double Monolith Necrons! They go into all of the details for how it works here.In part two of the show, available to our patrons deep dive into all of Justin's games with play by play tactics and strategies from the man himself!To support the show please check out our patreon for weekly exclusive content patreon.com/aow40k++ Army Roster (Xenos - Necrons) +++ Configuration +Battle Size: 2. Strike Force (2000 Point limit)Detachment Choice: Hypercrypt LegionShow/Hide Options: Legends are visible, Unaligned Forces are visible, Unaligned Fortifications are visible+ Character +Chronomancer: Dimensional Overseer, WarlordPlasmancer: Arisen Tyrant+ Battleline +Necron Warriors20x Warrior w/ gauss reaper: 20x Close combat weapon, 20x Gauss reaperNecron Warriors20x Warrior w/ gauss reaper: 20x Close combat weapon, 20x Gauss reaper+ Infantry +Deathmarks5x Deathmark: 5x Close combat weapon, 5x Synaptic disintegratorDeathmarks5x Deathmark: 5x Close combat weapon, 5x Synaptic disintegrator+ Vehicle +Canoptek ReanimatorCanoptek SpydersCanoptek Spyder: Fabricator claw array, Gloom prism, Two particle beamersDoomsday ArkDoomsday ArkMonolithFour death raysMonolithFour death rays

Product Minute: Synaptic software for your Android Phone or Tablet   What is Synaptic:   Synapptic is an all in one software or app package for people who are blind or vision impaired, , that works on android smartphones and tablets.   Synaptic overview:   Find your way around with clear and bright icons. All screens have the same look and feel. In other words, once you have learnt one screen, you will know everything you need to know to use all other screens. Never get lost and always find your way back to the main menu with the Red Cross at the top left corner of the screen. Customise the main menu to display as a grid on one screen to make finding things easier, rather than several menu screens. Touch and release touch screen control means you can move your finger up and down each menu option and it will be read out until you stop on the option you want to use. Control Synaptic with your voice and use voice dictation if you like instead of the on screen keyboard. Plus, you can also use a Bluetooth keyboard for navigation and typing as well. Change the magnification level,  colour scheme, screen brightness, speech and sound settings,  and of course the menus. help is available at the top right hand corner  of each Synapptic screen. Make and receive phone calls and text messages (only on devices with a SIMM card). Send, receive, and read  emails. Use the web browser to search and read what is on the internet. Listen to thousands of internet radio stations. Play music, books, and other MP3 recordings from device,  memory cards or USB sticks. Watch and enjoy what is on YouTube. Catch up with the news and other stories efficiently. Turn the camera in to a reading machine, hand held digital magnifier, colour detecter, access QR/Bar codes, and take and share photos. Find out your current location, and what may be of interest near you.   Other features:    address book. calendar,  Reminders, and alarms. Calculator. Compass and spirit level. Make and share text or voice notes. Use the stop watch,  and timer. Install and Run other apps such as Spotify, Zoom etc. If all of these features interest you, a download trial is available. See the shop page for this link. You can then purchase a license to register the Synaptic software.     For more information, please contact the Vision Store on phone 1 3 0 0, 8 4 7 , 4 6 6 or email visionstore@visionaustralia.org. https://shop.visionaustralia.org/everyday-technology/synapptic-software-for-android.html   ApleVIS Closing Down   After 14 years of volunteer operation, as of August 31 2024 Applevis will be closing down. Great content, and it will be missed. Site is in read only mode for now, so no new content will be available.   Speaking of Getting Help and Useful Resources   Don't forget about the help sites from Apple, Android, and Windows, plus our fantastic at Help Desk which you can reach via the main Vision Australia number or email athelp@visionaustralia.org   Tips on Stephen on How to listen to the 2024 Ylympics   Some great tips, as I have been finding it bit confusing myself on where to catch up on what is happening with the games.   Any Head Phone suggestions   Folks who follow me on social media will know I'm on a bit of a quest to find out suitable head phones to use when out and about, as my bone conduction Shokz just don't work in noisy environments.   Feel free to email me your head phone suggestions that you use to my work email: David.woodbridge@visionaustralia.orgSupport this Vision Australia Radio program: https://www.visionaustralia.org/donate?src=radio&type=0&_ga=2.182040610.46191917.1644183916-1718358749.1627963141See omnystudio.com/listener for privacy information.

Scientific Sense ® by Gill Eapen: Prof. Karla Kaun is Associate Professor of Neuroscience at Brown University. Her research interests include Synaptic networks of reward and addiction, cognitive decline, and effects of aging on substance abuse. Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1 --- Support this podcast: https://podcasters.spotify.com/pod/show/scientificsense/support

In this episode, we explore the intricacies of neuronal communication, delving into how neurons transmit signals through synaptic connections using neurotransmitters like glutamate and GABA. We also examine the effects of neurotoxins, such as heavy metals and environmental pollutants, on these critical synaptic pathways, leading to cognitive and neurological impairments. Lastly, we discuss neuroprotective strategies to mitigate neurotoxin exposure and promote optimal brain health. Topics: 1. Overview of Brain Cell Anatomy - Types of brain cells: neurons and glial cells. - Structure of neurons: - Soma (cell body): contains nucleus and organelles. - Dendrites: receive signals from other neurons. - Axon: transmits electrical impulses away from the soma. - Synaptic terminals: form synapses with target cells. 2. Neuronal Communication - Synapse structure: - Presynaptic terminal. - Synaptic cleft. - Postsynaptic membrane. - Neurotransmitters: - Role in neuronal communication. - Excitatory neurotransmitters (e.g., glutamate). - Inhibitory neurotransmitters (e.g., GABA). 3. Summary of Neuronal Communication - Recap of excitatory and inhibitory neurotransmitters. - Importance of maintaining proper neuronal communication. 4. Neurotoxins and Their Effects - Types of neurotoxins: - Heavy metals (e.g., lead, mercury, arsenic, cadmium, aluminum). - Chemical neurotoxins (e.g., organophosphates, solvents). - Biological toxins (e.g., mycotoxins). - Environmental pollutants (e.g., PCBs, dioxins). - Mechanisms of neurotoxin damage: - Disruption of neurotransmitter release. - Impairment of receptor function. - Interference with ion channel operation. 5. Example: Mercury's Impact on Cognitive Function - Pathway of mercury exposure and accumulation in the brain. - Disruption of calcium homeostasis and synaptic transmission. - Resulting cognitive impairments. 6. Strategies to Reduce Neurotoxin Exposure - Nutrition: - Opting for organic produce. - Washing produce properly. - Avoiding MSG and aspartame. - Limiting aluminum exposure (baking powder). - Evaluating cookware. - Avoiding farmed salmon. - Water and air quality: - Using water filtration to remove fluoride. - Choosing fluoride-free toothpaste. - Improving air quality and mold remediation. - Using air-purifying plants (e.g., aloe vera, English ivy). - Reducing exposure to places with highly-concentrated neurotoxic chemicals (e.g., nail salons). Thank you to our episode sponsor: ⁠⁠⁠Tremetes, LLC⁠ Use code CHLOE15 to get 15% off ⁠Tremetes' Turkey Tail⁠ Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

https://www.paypal.me/Truelifepodcast?locale.x=en_USAloha and welcome, dear listeners, to another illuminating episode of TrueLife Media, where we explore the fascinating intersections of community, consciousness, and the ever-evolving frontiers of human potential. Today, we are privileged to be joined by a true pioneer in the realms of neuroscience and biotechnology, whose work bridges the scientific and the spiritual in profound and transformative ways.Our esteemed guest, Dr. Iris Madrona, is a distinguished neuroscientist and the visionary CEO of an innovative early-stage biotech firm. With a Ph.D. in Neuroscience from Dartmouth College, Dr. Madrona has made groundbreaking contributions in genetic engineering and regenerative medicine, evidenced by their impressive portfolio of provisional patents. As the founder and director of the Interdisciplinary Research Institute at Shasta, Dr. Madrona is dedicated to leveraging neuroscience to tackle real-world challenges, spearheading research initiatives that advance wellness solutions through the intersection of neuroscience, mental health, and molecular biology.Dr. Madrona's research is as diverse as it is impactful, spanning the psychological and biological implications of music, the computational modeling of affective states, and the exploration of emotion, self, and psychometrics. Their interdisciplinary approach has significantly influenced early childhood program assessments and our understanding of emotional dynamics in the brain.Today, we delve into one of Dr. Madrona's most intriguing projects: the neurogenesis of vocalization circuits in songbirds, inspired by the neurogenerative properties of psychedelic compounds like ayahuasca. This project not only seeks to enhance our understanding of neural plasticity and neurogenesis but also holds the potential to revolutionize therapeutic approaches for vocal and cognitive rehabilitation.Dr. Madrona's work is a beautiful synthesis of science and spirituality, art and nature. Their dedication to integrating these realms is evident in their innovative study designs and their profound connection to the natural world. Inspired by personal experiences and a deep-seated belief in the healing power of music and psychedelics, Dr. Madrona's research offers new hope for those suffering from neurological damage and chronic disease.As we journey through this conversation, prepare to be inspired by Dr. Madrona's insights into the neurogenesis of song circuits, the ethical considerations of neural manipulation, and the future of psychedelic research. Their passion for pushing the boundaries of what we know about the brain and consciousness promises to leave us with much to ponder and reflect upon.Please join me in warmly welcoming the brilliant and innovative Dr. Iris Madrona.https://docs.google.com/document/d/12rB9J3ixrE-flDO0iJC4G_8tH2pUJCLASE8uGqdoJpA/edit?usp=sharingYou can find more of my work on my Patreon: https://www.patreon.com/irismadronaphd https://www.paypal.me/Truelifepodcast?locale.x=en_US

In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: info.fromthespectrum@gmail.com

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39453]

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39453]

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39453]

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39453]

Today's AI is largely based on supervised learning of neural networks using the backpropagation-of-error synaptic learning rule. This learning rule relies on differentiation of continuous activation functions and is thus not directly applicable to spiking neurons. Today's guest has developed the algorithm SuperSpike to address the problem. He has also recently developed a biologically more plausible learning rule based on self-supervised learning. We talk about both.  

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary. Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdfPTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue16p11.2, Serotonin, and Possible Social Deficit Rescueshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/https://www.nature.com/articles/s41586-018-0416-4https://www.nature.com/articles/s41386-021-01091-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/https://www.sciencedirect.com/science/article/pii/S0092867414006734(0:00) Introduction; Excitation and Inhibition; (3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should? (10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;(19:24) Back to 16p11.2 and Cortical Development;(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC(29:25) Wrap Up and Contact Informationemail: info.fromthespectrum@gmail.com

In this episode of the Crazy Wisdom Podcast, Stewart Alsop engages with senior data scientist Anand Divedi to delve deep into the facets of machine learning and AI's evolving capabilities. They discuss Anand's journey and insights into AI, particularly focusing on the freedom from execution boundaries brought by advancements in AI and large language models (LLMs). The conversation extends to the concept of 'human in the loop' learning, emphasizing the interdisciplinary approach to mimicking neural decision-making processes. Anand shares his initial foray into machine learning via financial surveillance to detect fraud utilizing AI to sift through massive data. They discuss the significance of teaching and learning for both AI models and humans, touching on aspects of cognitive pruning, memory, and how AI, much like the human brain, can 'forget' outdated information to make room for new learnings. The episode also introduces Haley Darden, who kicks off her segment on supervised learning, aiming to bridge the gap between technical AI concepts and everyday understanding. Together, they ponder over the future of AI in terms of model specialization versus generalization, and whether AI should or can forget information similar to human cognitive pruning. Check out this GPT we trained on this conversation Timestamps 00:41 Diving Deep with Anand Divedi: Exploring Machine Learning and Boundaries 01:23 The Evolution of Machine Learning: From Boundaries to Freedom 04:00 Bridging the Gap: Machine Learning for Technical and Non-Technical Minds 08:54 Human in the Loop: Merging AI with Human Decision-Making 10:20 From Financial Surveillance to AI: Anand's Journey into Machine Learning 14:13 Understanding AI: Parameters, Learning, and Growth 29:54 The Spiritual and Philosophical Dimensions of Learning and AI 37:28 Exploring Self-Reflection and Emotional Learning 38:12 The Role of Memory and Reflection in Learning 38:47 Introducing AI's Long-Term Memory and Reflection 39:10 Active Learning and the Structure of Self in AI 40:42 Welcoming Haley Darden and Discussing Supervised Learning 41:44 Breaking Down AI: From Basics to Complex Concepts 44:56 Understanding AI's Learning, Forgetting, and Trust Mechanisms 59:01 Concluding Thoughts and Future Directions Key Insights Breaking Boundaries in AI and Machine Learning: Anand Dwivedi shared a significant shift in his approach to AI, where he moved from conceptual boundaries to practical execution, experiencing a newfound sense of freedom. This reflects a broader trend in the AI field, where advancements in large language models (LLMs) and other technologies have drastically expanded the possibilities for innovation and application, enabling researchers and practitioners to explore new frontiers beyond traditional limitations. Human-in-the-Loop Learning: The conversation highlighted Anand's work in human-in-the-loop learning, emphasizing the integration of human decision-making processes within AI systems. This approach seeks to understand and replicate human reasoning in AI models, facilitating a symbiotic relationship where both humans and AI contribute to and enhance the learning process, thereby improving the accuracy and effectiveness of AI applications in real-world scenarios. The Evolution of AI through Large Language Models: Anand discussed the transformative impact of LLMs on his work, describing them as powerful tools for parsing and analyzing information. These models have revolutionized how AI can assist in structuring thoughts and accelerating research processes, showcasing the rapid development in AI's capabilities and the increasing sophistication of tools available to data scientists and researchers. The Importance of Frameworks in AI Learning: Throughout the podcast, the significance of frameworks in understanding and implementing AI was a recurring theme. Anand underscored the need for structured approaches to learning and applying AI, highlighting how frameworks can guide users in effectively leveraging AI capabilities, thus bridging the gap between technical complexity and practical usability. AI's Impact on Decision Making and Surveillance: Anand's insights into his career, particularly in financial surveillance, illustrated how AI can be pivotal in managing vast amounts of data to identify anomalies or fraudulent activities. This underscores AI's role in enhancing the efficiency and accuracy of decision-making processes in high-stakes environments, such as financial markets, where the ability to swiftly analyze and act on data is crucial. Neuroscience and AI: The discussion touched on the intersection of neuroscience and AI, with Anand exploring how AI models mimic neural processes. This comparison not only sheds light on the potential of AI to replicate human cognitive functions but also on the ongoing efforts to improve AI's learning and decision-making capabilities by understanding and emulating the complexities of the human brain. Future of AI and Ethical Considerations: The conversation ventured into the future trajectory of AI, including the ethical dimensions of AI development and application. Anand's dialogue with Hayley Darden in the latter part of the episode highlighted the challenges in ensuring AI's reliability and trustworthiness, addressing concerns such as AI hallucinations and the importance of developing robust mechanisms to evaluate and trust AI outputs, thereby ensuring AI's responsible and ethical integration into society.

Découvrez le livre NEUROSAPIENS ! Pour apprendre à créer rapidement et à moindre coût son podcast, c'est par ici ! Aujourd'hui, je vous propose une aventure assez exaltante à travers les méandres du cerveau adolescent. A l'image du bus magique (ref que seuls les millenials comprendront), je vous propose d'aller explorer un labyrinthe d'hormones, d'émotions et d'acrobaties neuronales au cœur du cerveau des adolescents. Dans cet épisode, nous allons regarder les changements qui se trament dans le cerveau lorsqu'on est adolescent, mais aussi bien sûr les changements hormonaux et comment ces deux dynamiques cérébrales et hormonales influencent nos comportements de prise de risque, nos relations sociales, notre sommeil, etc. Production, animation, réalisation : Anaïs RouxInstagram : https://www.instagram.com/neurosapiens.podcast/neurosapiens.podcast@gmail.comProduit et distribué en association avec LACME Production.Références : Chein J, Albert D, O'Brien L, Uckert K, Steinberg L. Peers increase adolescent risk taking by enhancing activity in the brain's reward circuitry. Dev Sci. 2011 Mar;14(2):F1-10. doi: 10.1111/j.1467-7687.2010.01035.x. PMID: 21499511; PMCID: PMC3075496.Steinberg L, Albert D, Cauffman E, Banich M, Graham S, Woolard J. Age differences in sensation seeking and impulsivity as indexed by behavior and self-report: evidence for a dual systems model. Dev Psychol. 2008 Nov;44(6):1764-78. doi: 10.1037/a0012955. PMID: 18999337.Carskadon MA. Sleep in adolescents: the perfect storm. Pediatr Clin North Am. 2011 Jun;58(3):637-47. doi: 10.1016/j.pcl.2011.03.003. PMID: 21600346; PMCID: PMC3130594.Brechwald WA, Prinstein MJ. Beyond Homophily: A Decade of Advances in Understanding Peer Influence Processes. J Res Adolesc. 2011 Mar 1;21(1):166-179. doi: 10.1111/j.1532-7795.2010.00721.x. PMID: 23730122; PMCID: PMC3666937.Blakemore SJ, Choudhury S. Development of the adolescent brain: implications for executive function and social cognition. J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):296-312. doi: 10.1111/j.1469-7610.2006.01611.x. PMID: 16492261.Figner B, Mackinlay RJ, Wilkening F, Weber EU. Affective and deliberative processes in risky choice: age differences in risk taking in the Columbia Card Task. J Exp Psychol Learn Mem Cogn. 2009 May;35(3):709-30. doi: 10.1037/a0014983. PMID: 19379045.Huttenlocher PR. Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res. 1979 Mar 16;163(2):195-205. doi: 10.1016/0006-8993(79)90349-4. PMID: 427544.Gunnar MR, Wewerka S, Frenn K, Long JD, Griggs C. Developmental changes in hypothalamus-pituitary-adrenal activity over the transition to adolescence: normative changes and associations with puberty. Dev Psychopathol. 2009 Winter;21(1):69-85. doi: 10.1017/S0954579409000054. Erratum in: Dev Psychopathol. 2010 Winter;22(1):237. PMID: 19144223; PMCID: PMC3933029.Parent AS, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev. 2003 Oct;24(5):668-93. doi: 10.1210/er.2002-0019. PMID: 14570750.Musique :ONE NIGHT AWAY de Patrick PatrikiosLOVE ASIDE de Patrick Patrikios

Join the Community Sign up to ‘A Helpful Newsletter' In this immersive episode of "This Might Be Helpful," Cameron Rosin dives deep into the world of synaptic debris, cognitive overwhelm, and the overwhelming influx of information in our digital age. Examining the impact of constant data consumption on our brains, Cameron sheds light on the physiological effects of processing excessive information. Unveiling the consequences of information outpacing integration, he explores the quest for clarity amidst an age of overwhelming digital noise. Get Cameron's guided meditation package: Meditations Follow Cameron on Instagram: Instagram Follow Cameron on TikTok: TikTok Subscribe to Cameron's Youtube: Youtube For more information visit https://camrosin.io/

Synaptic pruning is one of the most foundational ways to change the brain. In fact, it is the way the brain changes in structure and in function.  In this episode, I break down synaptic pruning into its most basic, scientific components, and talk about how you can use synaptic pruning to your advantage, in really simple ways.

Today we're joined by Kareem of Thrive Capital for one of the most extensive conversations we've had on the show—we cover the core insight that drove Thrive to invest in late-stage companies like Stripe and Slack, how they approach thinking about fund size and timing, the benefits of a concentrated portfolio, and more. If you're looking to improve your sourcing, tracking, and due diligence, check out: https://synaptic.com/turpentine --- SPONSORS: Synaptic unifies over one hundred real-time company performance metrics across alternative datasets like user traffic, employee data, app downloads, product reviews, and more. It's your all-in-one source for alternative data that helps you make better investment decisions. To learn how Synaptic can improve your sourcing, tracking, and due diligence, visit https://synaptic.com/turpentine Oracle Cloud Infrastructure (OCI) is a single platform for your infrastructure, database, application development, and AI needs. OCI has four to eight times the bandwidth of other clouds; offers one consistent price, instead of variable regional pricing; and of course nobody does data better than Oracle. If you want to do more and spend less, take a free test drive of OCI at https://oracle.com/turpentine --- Join our free newsletter to get Erik's top 3 insights from each episode every week: https://turpentinevc.substack.com/ --- RELATED SHOWS: If you like Turpentine VC, check out our show The Limited Partner with David Weisburd, where David talks to the investors behind the investors: https://link.chtbl.com/thelimitedpartner --- RECOMMENDED PODCAST:  Every week investor and writer of the popular newsletter The Diff, Byrne Hobart, and co-host Erik Torenberg discuss today's major inflection points in technology, business, and markets – and help listeners build a diversified portfolio of trends and ideas for the future. Subscribe to “The Riff” with Byrne Hobart and Erik Torenberg: https://link.chtbl.com/theriff RECOMMENDED PODCAST: LIVE PLAYERS Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. LIsten and subscribe everywhere you get your podcasts: https://link.chtbl.com/liveplayers. --- X / TWITTER: @kareemszaki (Kareem) @ThriveCapital (Thrive Capital) @eriktorenberg (Erik) @TurpentineVC --- TIMESTAMPS: (00:00) Intro (3:03) How does Thrive balance an opportunistic vs a focused approach (07:01) Thrive's structure and core insights (14:57) Sponsor: Synaptic (15:50) On Thrive's DNA (18:06) Kareem's insights on selling (24:01) Thrive's history (29:45) Sponsor: Oracle (33:10) Kareem's insights on the impact team  (36:21) On incubations (39:45) On regulated or capital intensive industries (43:06) Thrive and healthcare (49:37) How does Thrive think about macro? (53:14]) The future of Thrive (55:25) Kareem on making bets on young people and cultivating talent

This week's episode of Turpentine VC features Benchmark GPs Sarah Tavel and Eric Vishria. We discuss ideas that are central to Benchmark's beliefs in firm-building, including why platform teams exist to help the general partners more so than founders themselves. If you're looking to improve your sourcing, tracking, and due diligence, check out: https://synaptic.com/turpentine --- SPONSORS: Synaptic unifies over one hundred real-time company performance metrics across alternative datasets like user traffic, employee data, app downloads, product reviews, and more. It's your all-in-one source for alternative data that helps you make better investment decisions. To learn how Synaptic can improve your sourcing, tracking, and due diligence, visit https://synaptic.com/turpentine Oracle Cloud Infrastructure (OCI) is a single platform for your infrastructure, database, application development, and AI needs. OCI has four to eight times the bandwidth of other clouds; offers one consistent price, instead of variable regional pricing; and of course nobody does data better than Oracle. If you want to do more and spend less, take a free test drive of OCI at https://oracle.com/turpentine. --- Join our free newsletter to get Erik's top 3 insights from each episode every week: https://turpentinevc.substack.com/ --- RELATED SHOWS: If you like Turpentine VC, check out our show The Limited Partner with David Weisburd, where David talks to the investors behind the investors: https://link.chtbl.com/thelimitedpartner --- RECOMMENDED PODCAST:  Every week investor and writer of the popular newsletter The Diff, Byrne Hobart, and co-host Erik Torenberg discuss today's major inflection points in technology, business, and markets – and help listeners build a diversified portfolio of trends and ideas for the future. Subscribe to “The Riff” with Byrne Hobart and Erik Torenberg: https://link.chtbl.com/theriff RECOMMENDED PODCAST: LIVE PLAYERS Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. LIsten and subscribe everywhere you get your podcasts: https://link.chtbl.com/liveplayers. --- X / TWITTER: @sarahtavel (Sarah) @ericvishria (Eric) @eriktorenberg (Erik) @benchmark (Benchmark) @TurpentineVC --- TIMESTAMPS: (00:00) Episode Preview (01:29) Benchmark in the history of venture capital (05:08) The Benchmark DNA (07:50) Learnings from Benchmark's expansion (10:53) Sponsor: Synaptic (11:55) The trade-offs of scaling (13:00) How Benchmark thinks about macro (15:08) Comparing the different Benchmark eras (17:46) Partnership construction and combining skill sets and personalities (29:38) On the investor and founder relationship (33:58) Sponsor: Oracle (39:10) How Benchmark remains one of the most relevant VC firms (44:30) The right business model for venture scale (48:24) the hallmark of a Benchmark company (52:52) Learnings from consumer social (1:08:43) What types of companies have enduring value or are truly defensible? (1:15:09) On crypto (1:23:47) Re-founding Benchmark

Erik is joined by Alfred Lin, partner at Sequoia Capital for over 13 years, and investor in Airbnb, Doordash, Houzz, and more legendary Silicon Valley companies. We dive into the unique ways which Sequoia operates as a firm in this episode: why they don't actually track A-U-M, why they launched the Sequoia Capital Fund, the decision-making behind creating Sequoia Arc, and more. If you're looking to improve your sourcing, tracking, and due diligence, check out: https://synaptic.com/turpentine --- SPONSORS: Synaptic unifies over one hundred real-time company performance metrics across alternative datasets like user traffic, employee data, app downloads, product reviews, and more. It's your all-in-one source for alternative data that helps you make better investment decisions. To learn how Synaptic can improve your sourcing, tracking, and due diligence, visit https://synaptic.com/turpentine Oracle Cloud Infrastructure (OCI) is a single platform for your infrastructure, database, application development, and AI needs. OCI has four to eight times the bandwidth of other clouds; offers one consistent price, instead of variable regional pricing; and of course nobody does data better than Oracle. If you want to do more and spend less, take a free test drive of OCI at https://oracle.com/turpentine. --- Join our free newsletter to get Erik's top 3 insights from each episode every week: https://turpentinevc.substack.com/ --- RECOMMENDED PODCAST:  Every week investor and writer of the popular newsletter The Diff, Byrne Hobart, and co-host Erik Torenberg discuss today's major inflection points in technology, business, and markets – and help listeners build a diversified portfolio of trends and ideas for the future. Subscribe to “The Riff” with Byrne Hobart and Erik Torenberg: https://link.chtbl.com/theriff RECOMMENDED PODCAST: LIVE PLAYERS Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. LIsten and subscribe everywhere you get your podcasts: https://link.chtbl.com/liveplayers. --- X / TWITTER: @Alfred_Lin (Alfred) @eriktorenberg (Erik) @sequoia (Sequoia) @TurpentineVC --- TIMESTAMPS: (00:00) Episode preview (01:10) How Sequoia does generational transitions (05:31) Sequoia's firm structure and evolution (11:01) Sponsor: Synaptic (11:52) On Sequoia Arc and competing against YC (15:01) On metrics and leading indicators (18:19) How to add the most value to founders (23:33) Alfred on the landscape of venture in 2030 (25:39) What makes a Sequoia partner great? (28:40) Sponsor: Oracle Clound Infrastructure (33:02) On incubations (34:53) On macro (38:56) Alfred's thoughts on AI (43:33) Leadership and how to show up for founders (49:42) Alfredisms: the time span of discretion and the roles of a founder

On episode eleven of Turpentine VC, Ann Miura-Ko—co-founding partner at Floodgate—sits down with Erik Torenberg to dive deep into the core fundamentals of VC partners talk about behind close doors, including how to identify inflection points to give you an edge when starting a fund, muscles Floodgate has built in the -1 to 0 space, the true opportunities in AI, and more. If you're looking to improve your sourcing, tracking, and due diligence, check out: https://synaptic.com/turpentine --- SPONSORS: Synaptic unifies over one hundred real-time company performance metrics across alternative datasets like user traffic, employee data, app downloads, product reviews, and more. It's your all-in-one source for alternative data that helps you make better investment decisions. To learn how Synaptic can improve your sourcing, tracking, and due diligence, visit https://synaptic.com/turpentine --- RECOMMENDED PODCAST:  Every week investor and writer of the popular newsletter The Diff, Byrne Hobart, and co-host Erik Torenberg discuss today's major inflection points in technology, business, and markets – and help listeners build a diversified portfolio of trends and ideas for the future. Subscribe to “The Riff” with Byrne Hobart and Erik Torenberg: https://link.chtbl.com/theriff RECOMMENDED PODCAST: LIVE PLAYERS Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. LIsten and subscribe everywhere you get your podcasts: https://link.chtbl.com/liveplayers. --- Join our free newsletter to get Erik's top 3 insights from each episode every week: https://turpentinevc.substack.com/ --- RELATED SHOWS: If you like Turpentine VC, check out our show The Limited Partner with David Weisburd, where David talks to the investors behind the investors: https://link.chtbl.com/thelimitedpartner --- X / TWITTER: @annimaniac (Ann) @eriktorenberg (Erik) @floodgatefund @TurpentineVC --- TIMESTAMPS: (00:00) Episode preview (01:29) How Ann thinks about macro (04:33) Is 2023 better for incumbents or start-ups? (07:12) When is the right time to start a fund? (10:23) How Ann identifies inflections that guide her approach to innovative VC (12:40) Sponsor: Synaptic (15:43) Why Floodgate's fund size is their strategy (19:36) Ann's litmus test for product market fit (22:32) What would prompt Floodgate to change their strategy? (25:51) On how Ann evaluates people (28:02) Muscles Floodgate has built on the -1 to 0 space (31:52) Ann's thoughts on Sam's Factory Model Venture theory (39:22) AI as an inflection point (44:11) Ann's thoughts on exciting opportunities in AI

Trae Stephens, General Partner at Founders Fund, joins Erik Torenberg to chat through how the firm's focus on independent thinking and debate culture, and counterintuitive lack of true process, has been key in helping them build an enduring fund. If you're looking to improve your sourcing, tracking, and due diligence, check out: https://synaptic.com/turpentine We're hiring across the board at Turpentine and for Erik's personal team on other projects he's incubating. He's hiring a Chief of Staff, EA, Head of Special Projects, Investment Associate, and more. For a list of JDs, check out: eriktorenberg.com. --- SPONSORS: Synaptic unifies over one hundred real-time company performance metrics across alternative datasets like user traffic, employee data, app downloads, product reviews, and more. It's your all-in-one source for alternative data that helps you make better investment decisions. To learn how Synaptic can improve your sourcing, tracking, and due diligence, visit https://synaptic.com/turpentine --- RECOMMENDED PODCAST:  Every week investor and writer of the popular newsletter The Diff, Byrne Hobart, and co-host Erik Torenberg discuss today's major inflection points in technology, business, and markets – and help listeners build a diversified portfolio of trends and ideas for the future. Subscribe to “The Riff” with Byrne Hobart and Erik Torenberg: https://link.chtbl.com/theriff RECOMMENDED PODCAST: LIVE PLAYERS Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. LIsten and subscribe everywhere you get your podcasts: https://link.chtbl.com/liveplayers. --- Join our free newsletter to get Erik's top 3 insights from each episode every week: https://turpentinevc.substack.com/ --- RELATED SHOWS: If you like Turpentine VC, check out our show The Limited Partner with David Weisburd, where David talks to the investors behind the investors: https://link.chtbl.com/thelimitedpartner --- X / TWITTER: @traestephens (Trae) @eriktorenberg (Erik) @foundersfund @TurpentineVC --- TIMESTAMPS: (00:00) Episode preview (01:24) Debate culture and why that's key to Founders Fund's success (03:59) How Founders Fund's pitch is different from a16z's (06:56) FF's unique market position (09:09) How FF recruits their partners (13:10) Sponsor: Synaptic (14:16) The deal-making process, or lack thereof (16:14) Governance at Founders Fund (19:27) Comparing the YC approach  (21:41) How they measure success against other funds (22:50) Trae's journey at Founders Fund (24:54) On incubating Anduril (28:04) Why having no process forces partners to be higher conviction (30:15) Core debates at Founders Fund (32:24) The key to Founders Fund's current approach (34:22) Trae's request for startups in gov tech (36:03) Erik's On Deck question (37:58) What does the future look like for Founders Fund? (39:47) What gets misunderstood about the firm (44:06) On Mike Solana (47:01) The three eras of Founders Fund summarized

Sam Lessin, General Partner at Slow Ventures, and Seth Rosenberg, General Partner at Greylock, debate what the effects of AI on incumbents and the next wave of AI-first products will look like. If you're looking to improve your sourcing, tracking, and due diligence, check out: https://synaptic.com/turpentine We're hiring across the board at Turpentine and for Erik's personal team on other projects he's incubating. He's hiring a Chief of Staff, EA, Head of Special Projects, Investment Associate, and more. For a list of JDs, check out: eriktorenberg.com. --- SPONSORS: Synaptic unifies over one hundred real-time company performance metrics across alternative datasets like user traffic, employee data, app downloads, product reviews, and more. It's your all-in-one source for alternative data that helps you make better investment decisions. To learn how Synaptic can improve your sourcing, tracking, and due diligence, visit https://synaptic.com/turpentine --- RECOMMENDED PODCAST:  Every week investor and writer of the popular newsletter The Diff, Byrne Hobart, and co-host Erik Torenberg discuss today's major inflection points in technology, business, and markets – and help listeners build a diversified portfolio of trends and ideas for the future. Subscribe to “The Riff” with Byrne Hobart and Erik Torenberg: https://link.chtbl.com/theriff RECOMMENDED PODCAST: LIVE PLAYERS Join host Samo Burja and Erik Torenberg as they analyze the mindsets of today's most intriguing business leaders, investors, and innovators through the lens of their bold actions and contrarian worldviews. You'll come away with a deeper understanding of the development of technology, business, political power, culture and more. LIsten and subscribe everywhere you get your podcasts: https://link.chtbl.com/liveplayers. --- Join our free newsletter to get Erik's top 3 insights from each episode every week: https://turpentinevc.substack.com/ --- LINKS: Seth's essay on Product-Led AI: https://greylock.com/greymatter/seth-rosenberg-product-led-ai/ --- RELATED SHOWS: If you like Turpentine VC, check out our show The Limited Partner with David Weisburd, where David talks to the investors behind the investors: https://link.chtbl.com/thelimitedpartner For more AI content, check out The Cognitive Revolution with Nathan Labenz, where Nathan covers the most pertinent AI updates in the industry with builders, investors, and more: https://link.chtbl.com/TheCognitiveRevolution --- X / TWITTER: @lessin (Sam) @SethGRosenberg (Seth) @eriktorenberg (Erik) @TurpentineVC --- TIMESTAMPS: (00:00) Episode preview (00:47) Seth's blog post on opportunities in AI (04:46) Sam's reaction to Seth's product-led AI thesis (9:58) Identifying outliers (12:29) What happening during the cloud, mobile, and AI tech waves (14:51) Sponsor: Synaptic (15:52) Why incumbents are incredibly well-positioned to add AI tools (19:08) The mobile tech wave and why incumbents won (21:59) The Uber of the AI era (26:11) New markets unlocked with AI (28:26) Defensibility of AI startups (32:28) Thoughts on Midjourney and Character AI (34:01) Closing remarks (37:26) ​​On copilots