Antibuddies

In this multipart monolog, Jatin talks about some milestone discoveries related to natural killer cells. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Sources:· Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer - PMC Five decades of natural killer cell discovery | Journal of Experimental Medicine | Rockefeller University Press

In this monolog, Casey discusses a 2024 article about the increase in health and lifespan in mammals after IL-11 inhibition.

In this monolog, Vijay discusses the difference in immune system development in term and pre-term babies. Sources: https://pubmed.ncbi.nlm.nih.gov/30142345/

In this monolog, Akshat ponders about the spatiotemporal underpinnings of cytokine concentrations in tissue niches...and how it all appears to function like a gossip network.

In this episode, Akshat outlines the salient features of CAR or TCR-engineered T cells, and deigns to ponder: is one modality just objectively better than the other?

In this Monolog, Casey discusses the unique case of a hyper-vaccinated individual in Germany with more than 200 COVID-19 vaccines and how his immunological profile looks like.

In this Monolog, Akshat discusses how the liver "speaks" both immunity and metabolism via bile to control hepatic tumors. Liver X Receptors also make an appearance.

In the 29th episode of our Immunology 101 series, Ash and Tanu start the new year 2024 with a discussion on Barrier Immunity with a focus on the gut.

In this monologue, Akshat talks about sterile inflammation, or leucocyte activation in the absence of inflammatory responses. These carefully regulated "internal affairs" of the immune system can be pathological or protective.

In this monolog, Casey talks about a 2023 article from the National Institute of Biological Sciences (Beijun, China) about the role of cytokines and immune cells in sleep deprivation-induced mortality. Source: Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals - PubMed (nih.gov)

In this monolog, Vijay talks about a 2016 article from Rockefeller University about the complex crosstalk in the gut between the neurons and macrophages.

In the 28th episode of our Immunology 101 series, Ash and Jatin talk continue discussion on cytotoxic T cells and transition into their functional cousins - the natural killer cells.

In the 27th episode of our Immunology 101 series, Ash and Jatin talk about how cytotoxic T cells deliver the kiss of death to their targets.

In the 26th episode of our Immunology 101 series, Ash and Jatin shift gears from humoral immunity to cellular immunity and discuss cytotoxic T cell activation.

In the 25th episode of our Immunology 101 series, Koshika and Jatin discuss Fc receptors and Antibody isotypes and relate them to specific effector functions.

In the 24th episode of our Immunology 101 series, Ash and Jatin discuss the various effector functions of Antibodies

In the 23rd episode of our Immunology 101 series, Ash, Koshika, and Jatin discuss the events taking place inside the germinal center - class switching and somatic hypermutation.

In the 22nd episode of our Immunology 101 series, Ash, Koshika, and Jatin talk about the events of the germinal centers.

In the 21st episode of our Immunology 101 series, Ash and Jatin talk about the fate of the B cell after it encounters the antigen and how it travels through the various compartments of a secondary lymphoid organ.

In this Buddisode, we sit down with Dr. Nataliya Prokhnevska to discuss her work on the fate and role of non-cytotoxic CD8+ T cells found in the tumor-draining lymph nodes of cancer patients.

In this monolog, Vijay talks about a recent article describing the communication between the vagus nerve and the pancreas.

In the 20th episode of Immunology 101 series, Ash, Koshika, and Jatin shift gears to talk about B cell activation and draw parallels with T cell activation process.

In the 19th episode of the Immunology 101 series, Ash, Koshika, and Jatin talk continue their conversation about T cell subsets with a focus on memory T cells.

In the 18th episode of Immunology 101 series, Ash, Koshika, and Jatin talk about classification of T helper cells and their functions.

In this Buddisode, we sit down with Drs. Cosima T Baldari & Rino Rappuoli to discuss their work on a unique immune evasion strategy deployed by SARS CoV2 to paralyze cytotoxic T cells.

In the 17th episode of Immunology 101 series, Natalie and Jatin talk about the T cell activation process and make some very lame jokes.

In this monolog, Natalie talks about the evolutionary history of the immune system.

In this Buddisode, we sit down with Dr. Simon Bélanger from the La Jolla Institute of Immunology (currently at Vir Biotechnology) to discuss his work on a transcription factor that can define early T follicular helper cell fate.

In this Buddisode, we sit down with Dr. Emilie Cosway from the Institute of Immunology and Immunotherapy at the University of Birmingham (UK) to discuss her recent paper about the mechanisms behind thymic regeneration.

In this buddisode, we sit down with Dr. Melissa Lechner from the Division of Endocrinology, Diabetes, and Metabolism at the UCLA David Geffen School of Medicine to discuss her recent paper about the mechanisms behind immune checkpoint inhibitor-induced autoimmune thyroiditis.

We sit down with Dr. Jessica Lancaster from the Department of Immunology, Mayo clinic to discuss her recent paper about the effect of Aging on Central Tolerance and Treg induction.

In the 16th episode of Immunology 101 series, Natalie and Jatin talk about an undergrad's worst nightmare 2 months into the immunology course - The complement system.

We sit down with Dr. Nardhy Gomez-Lopez from the Department of Obstetrics and Gynecology at Wayne State University to discuss her recent paper about the role of IL-22 in pregnancy and pre-term births.

Natalie and Jatin talk about positive and negative regulation in immune response, how the cells of the innate immunity interact with the adaptive, and the ubiquity of the immune system across phyla.

In the 14th episode of Immunology 101 series, Natalie and Jatin talk about the cellular facet of the innate immune system.

Eugenio and Jatin sit down with Dr. Jorge-Dominguez Andres (Ph.D.) from Radboud University to discuss trained immunity and its transgenerational inheritance in mice.

We continue our discussion with Dr. Adewunmi Adelaja (M.D., Ph.D.), from the University of California Los Angeles, about NFkB signaling and how signals to different stimuli are relayed inside macrophages.

We sit down with Dr. Adewunmi Adelaja (M.D., Ph.D.) from the University of California Los Angeles to discuss NFkB signaling and how signals to different stimuli are relayed inside macrophages.

In this monolog, Tanu breaks down a recent study that elucidates the mechanism behind the loss of sense of smell in COVID19 patients.

In this monolog, Vijay highlights some of the interactions between the neurons and the immune cells that show an intricately woven neuroimmune network.

We sit down with Dr. Yosuke Kumamoto from Rutgers new jersey medical school to discuss the role of a specific subset of DCs that retain lymphocytes in the SLOs to scan the repertoire post-immunization.

In this monolog, Natalie explains how cancer is a disease of the immune system.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.

In the 13th episode of Immunology 101 series, Natalie and Jatin continue talking about PRR signaling.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Sources:Kuby Immunology

In the 12th episode of Immunology 101 series, Natalie and Jatin shift gears to talk about Innate immunity with a focus on TLR signaling.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Sources:Kuby Immunology

In this breast cancer awareness month special monolog, Tanu talks about the challenges faced for breast cancer research and finding an effective treatment that works for everyone.

Immunology 101

In the 2nd part of the Origin of Eukaryotes series, Dara and Jatin sit down with Dr. Dylan G Ryan from University of Cambridge (formerly at Trinity College Dublin) to discuss his 2020 perspective article about the role of TCA cycle in Eukaryogenesis.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: TCA cycle signalling and the evolution of eukaryotes (nih.gov)

In the 1st part of the Origin of Eukaryotes series, Dara and Jatin sit down with Dr. Dylan G Ryan from University of Cambridge (formerly at Trinity College Dublin) to discuss his 2020 perspective article about the role of TCA cycle in Eukaryogenesis.

In the 2nd part of the phase separation series, Eugenio, Natalie, & Jatin sit down with Xiaolei Su, Qian Xiao, and Ceara McAtee continue their discussion.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: Phase separation in immune signalling | Nature Reviews Immunology

In this Buddisode, Eugenio, Natalie, & Jatin sit down with Xiaolei Su, Qian Xiao, and Ceara McAtee from Yale cancer center at Yale university to discuss their latest review article published in Nature Immunology Reviews in July of 2021.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: Phase separation in immune signalling | Nature Reviews Immunology

In this Buddisode, Dara, Eugenio, Natalie, & Jatin sit down with Daniel from Gretchen Diehl's lab at Memorial Sloan Kettering Cancer Center, NY. The discussion entails their 2021 paper about the development of bacteria-specific T cells in the thymus of young mice and all the implications surrounding this discovery. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Article of discussion: Thymic development of gut-microbiota-specific T cells | Nature