Antibuddies

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Everything about immunology

Antibuddies


    • Apr 14, 2025 LATEST EPISODE
    • infrequent NEW EPISODES
    • 37m AVG DURATION
    • 95 EPISODES


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    Latest episodes from Antibuddies

    Monolog 21 - Discovery of NK cells (Part-1)

    Play Episode Listen Later Apr 14, 2025 10:49


    In this multipart monolog, Jatin talks about some milestone discoveries related to natural killer cells. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Sources:· Natural Killer Cells and Cytotoxic T Cells: Complementary Partners against Microorganisms and Cancer - PMC Five decades of natural killer cell discovery | Journal of Experimental Medicine | Rockefeller University Press

    Monolog 20 - The Fountain of IL-11 Youth

    Play Episode Listen Later Oct 7, 2024 10:51


    In this monolog, Casey discusses a 2024 article about the increase in health and lifespan in mammals after IL-11 inhibition.

    Monolog 19 - Term vs Pre-term immune development

    Play Episode Listen Later Sep 23, 2024 11:33


    In this monolog, Vijay discusses the difference in immune system development in term and pre-term babies. Sources: https://pubmed.ncbi.nlm.nih.gov/30142345/

    Monolog 18 - Interleakin'

    Play Episode Listen Later Aug 27, 2024


    In this monolog, Akshat ponders about the spatiotemporal underpinnings of cytokine concentrations in tissue niches...and how it all appears to function like a gossip network.

    Monolog 17 - CAR-T and TCR-T Cells Face Off!

    Play Episode Listen Later Jul 29, 2024 15:28


    In this episode, Akshat outlines the salient features of CAR or TCR-engineered T cells, and deigns to ponder: is one modality just objectively better than the other?

    Monolog 16 - 217 COVID boosters and counting

    Play Episode Listen Later Jul 6, 2024


    In this Monolog, Casey discusses the unique case of a hyper-vaccinated individual in Germany with more than 200 COVID-19 vaccines and how his immunological profile looks like.

    Monolog 15 - The Liver is Bile-lingual

    Play Episode Listen Later Mar 7, 2024 16:12


    In this Monolog, Akshat discusses how the liver "speaks" both immunity and metabolism via bile to control hepatic tumors. Liver X Receptors also make an appearance.

    Ep29 - Barrier immunity & the gut

    Play Episode Listen Later Feb 4, 2024 21:46


    In the 29th episode of our Immunology 101 series, Ash and Tanu start the new year 2024 with a discussion on Barrier Immunity with a focus on the gut.

    Monolog 14 - Sterile inflammation

    Play Episode Listen Later Jan 30, 2024 11:10


    In this monologue, Akshat talks about sterile inflammation, or leucocyte activation in the absence of inflammatory responses. These carefully regulated "internal affairs" of the immune system can be pathological or protective.

    Monolog 13 - Sleep tight, don't let the cytokine storm bite

    Play Episode Listen Later Jan 21, 2024 12:42


    In this monolog, Casey talks about a 2023 article from the National Institute of Biological Sciences (Beijun, China) about the role of cytokines and immune cells in sleep deprivation-induced mortality. Source: Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals - PubMed (nih.gov)

    Monolog 12 - Gut is the multiverse of neuroimmune activities

    Play Episode Listen Later Jan 16, 2024 9:35


    In this monolog, Vijay talks about a 2016 article from Rockefeller University about the complex crosstalk in the gut between the neurons and macrophages.

    Ep28 - The Natural killers

    Play Episode Listen Later Dec 23, 2023 36:09


    In the 28th episode of our Immunology 101 series, Ash and Jatin talk continue discussion on cytotoxic T cells and transition into their functional cousins - the natural killer cells.

    Ep27 - The kiss of death

    Play Episode Listen Later Nov 12, 2023 28:12


    In the 27th episode of our Immunology 101 series, Ash and Jatin talk about how cytotoxic T cells deliver the kiss of death to their targets.

    Ep26 - Cytotoxic T cells

    Play Episode Listen Later Oct 21, 2023 30:26


    In the 26th episode of our Immunology 101 series, Ash and Jatin shift gears from humoral immunity to cellular immunity and discuss cytotoxic T cell activation.

    Ep25 - Fc receptors & Antibody isotypes

    Play Episode Listen Later Sep 10, 2023 32:42


    In the 25th episode of our Immunology 101 series, Koshika and Jatin discuss Fc receptors and Antibody isotypes and relate them to specific effector functions.

    Ep23 - Antibody effector functions

    Play Episode Listen Later Aug 13, 2023 22:18


    In the 24th episode of our Immunology 101 series, Ash and Jatin discuss the various effector functions of Antibodies

    Ep23 - Somatic hypermutation and Class switching

    Play Episode Listen Later Jul 15, 2023 22:42


    In the 23rd episode of our Immunology 101 series, Ash, Koshika, and Jatin discuss the events taking place inside the germinal center - class switching and somatic hypermutation.

    Ep22 - B cells in the germinal center

    Play Episode Listen Later Jun 25, 2023 29:03


    In the 22nd episode of our Immunology 101 series, Ash, Koshika, and Jatin talk about the events of the germinal centers.

    Ep21 - Fate of a B cell

    Play Episode Listen Later Jun 4, 2023 40:13


    In the 21st episode of our Immunology 101 series, Ash and Jatin talk about the fate of the B cell after it encounters the antigen and how it travels through the various compartments of a secondary lymphoid organ.

    Bep40 - Non-canonical T cell activation in TDLNs

    Play Episode Listen Later May 15, 2023 71:43


    In this Buddisode, we sit down with Dr. Nataliya Prokhnevska to discuss her work on the fate and role of non-cytotoxic CD8+ T cells found in the tumor-draining lymph nodes of cancer patients.

    Monolog 11 - Neuro-Pancreas Chat

    Play Episode Listen Later May 5, 2023 11:59


    In this monolog, Vijay talks about a recent article describing the communication between the vagus nerve and the pancreas.

    Ep20 - B cells are mean

    Play Episode Listen Later Apr 23, 2023 26:00


    In the 20th episode of Immunology 101 series, Ash, Koshika, and Jatin shift gears to talk about B cell activation and draw parallels with T cell activation process.

    Ep19 - Memory T cells

    Play Episode Listen Later Apr 2, 2023 28:09


    In the 19th episode of the Immunology 101 series, Ash, Koshika, and Jatin talk continue their conversation about T cell subsets with a focus on memory T cells.

    Ep18 - T helper classification and polarization

    Play Episode Listen Later Mar 26, 2023 31:06


    In the 18th episode of Immunology 101 series, Ash, Koshika, and Jatin talk about classification of T helper cells and their functions.

    Bep39 - How SARS CoV2 aces cytotoxic T cells

    Play Episode Listen Later Mar 15, 2023 73:46


    In this Buddisode, we sit down with Drs. Cosima T Baldari & Rino Rappuoli to discuss their work on a unique immune evasion strategy deployed by SARS CoV2 to paralyze cytotoxic T cells.

    Ep17 - T cell activation

    Play Episode Listen Later Feb 5, 2023 40:11


    In the 17th episode of Immunology 101 series, Natalie and Jatin talk about the T cell activation process and make some very lame jokes.

    Monolog 10 - Evolution of Immunity

    Play Episode Listen Later Dec 27, 2022 12:20


    In this monolog, Natalie talks about the evolutionary history of the immune system.

    Bep38 - Yin and Yang of Tfh

    Play Episode Listen Later Nov 15, 2022 50:56


    In this Buddisode, we sit down with Dr. Simon Bélanger from the La Jolla Institute of Immunology (currently at Vir Biotechnology) to discuss his work on a transcription factor that can define early T follicular helper cell fate.

    Bep37 - You won't believe what your eosinophils are doing!

    Play Episode Listen Later Oct 23, 2022 47:57


    In this Buddisode, we sit down with Dr. Emilie Cosway from the Institute of Immunology and Immunotherapy at the University of Birmingham (UK) to discuss her recent paper about the mechanisms behind thymic regeneration.

    Bep36 - IL17A and ICI-induced autoimmune thyroiditis

    Play Episode Listen Later Sep 29, 2022 43:32


    In this buddisode, we sit down with Dr. Melissa Lechner from the Division of Endocrinology, Diabetes, and Metabolism at the UCLA David Geffen School of Medicine to discuss her recent paper about the mechanisms behind immune checkpoint inhibitor-induced autoimmune thyroiditis.

    Bep35 - Aging affects Central Tolerance

    Play Episode Listen Later Sep 7, 2022 62:44


    We sit down with Dr. Jessica Lancaster from the Department of Immunology, Mayo clinic to discuss her recent paper about the effect of Aging on Central Tolerance and Treg induction.

    Ep16 - Pathways of the Complement System

    Play Episode Listen Later Aug 9, 2022 30:43


    In the 16th episode of Immunology 101 series, Natalie and Jatin talk about an undergrad's worst nightmare 2 months into the immunology course - The complement system.

    Bep34 - A tale of labor, pre-term birth, and IL-22

    Play Episode Listen Later Jun 21, 2022 75:17


    We sit down with Dr. Nardhy Gomez-Lopez from the Department of Obstetrics and Gynecology at Wayne State University to discuss her recent paper about the role of IL-22 in pregnancy and pre-term births.

    Ep15 - Regulation of Innate Immunity

    Play Episode Listen Later Apr 21, 2022 33:09


    Natalie and Jatin talk about positive and negative regulation in immune response, how the cells of the innate immunity interact with the adaptive, and the ubiquity of the immune system across phyla.

    Ep14 - Innate Immune Cells

    Play Episode Listen Later Mar 31, 2022 28:15


    In the 14th episode of Immunology 101 series, Natalie and Jatin talk about the cellular facet of the innate immune system.

    Bep33 - Transgenerational trained immunity

    Play Episode Listen Later Mar 21, 2022 52:32


    Eugenio and Jatin sit down with Dr. Jorge-Dominguez Andres (Ph.D.) from Radboud University to discuss trained immunity and its transgenerational inheritance in mice.

    Bep32 - 6 shades of NF-kB #2

    Play Episode Listen Later Feb 27, 2022 52:19


    We continue our discussion with Dr. Adewunmi Adelaja (M.D., Ph.D.), from the University of California Los Angeles, about NFkB signaling and how signals to different stimuli are relayed inside macrophages.

    Bep31 - 6 shades of NF-kB #1

    Play Episode Listen Later Feb 18, 2022 49:54


    We sit down with Dr. Adewunmi Adelaja (M.D., Ph.D.) from the University of California Los Angeles to discuss NFkB signaling and how signals to different stimuli are relayed inside macrophages.

    Monolog 9 - Why do we lose smell after COVID19?

    Play Episode Listen Later Feb 8, 2022 8:07


    In this monolog, Tanu breaks down a recent study that elucidates the mechanism behind the loss of sense of smell in COVID19 patients.

    Monolog 8 - Neuroimmune interactions

    Play Episode Listen Later Jan 29, 2022 9:38


    In this monolog, Vijay highlights some of the interactions between the neurons and the immune cells that show an intricately woven neuroimmune network.

    Bep30 - Finding the right clone

    Play Episode Listen Later Jan 17, 2022 59:01


    We sit down with Dr. Yosuke Kumamoto from Rutgers new jersey medical school to discuss the role of a specific subset of DCs that retain lymphocytes in the SLOs to scan the repertoire post-immunization.

    Monolog 7 - Cancer is an immune disease

    Play Episode Listen Later Jan 5, 2022 14:21


    In this monolog, Natalie explains how cancer is a disease of the immune system.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.

    Ep13 - Innate immunity and other PRRs

    Play Episode Listen Later Nov 24, 2021 34:18


    In the 13th episode of Immunology 101 series, Natalie and Jatin continue talking about PRR signaling.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Sources:Kuby Immunology

    Ep12 - Innate immunity and TLR signaling

    Play Episode Listen Later Nov 10, 2021 36:44


    In the 12th episode of Immunology 101 series, Natalie and Jatin shift gears to talk about Innate immunity with a focus on TLR signaling.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Sources:Kuby Immunology

    Monolog 6 - TIM3 and Breast cancer

    Play Episode Listen Later Oct 26, 2021 15:22


    In this breast cancer awareness month special monolog, Tanu talks about the challenges faced for breast cancer research and finding an effective treatment that works for everyone.

    Ep11 - B cell development in the spleen

    Play Episode Listen Later Oct 19, 2021 30:01


    Bep29 - Origin of Eukaryotes and the TCA cycle #2

    Play Episode Listen Later Oct 2, 2021 31:27


    In the 2nd part of the Origin of Eukaryotes series, Dara and Jatin sit down with Dr. Dylan G Ryan from University of Cambridge (formerly at Trinity College Dublin) to discuss his 2020 perspective article about the role of TCA cycle in Eukaryogenesis.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: TCA cycle signalling and the evolution of eukaryotes (nih.gov)

    Bep28 - Origin of Eukaryotes and the TCA cycle #1

    Play Episode Listen Later Sep 26, 2021 47:33


    In the 1st part of the Origin of Eukaryotes series, Dara and Jatin sit down with Dr. Dylan G Ryan from University of Cambridge (formerly at Trinity College Dublin) to discuss his 2020 perspective article about the role of TCA cycle in Eukaryogenesis.

    Bep27 - Phase separation in Immune Signaling #2

    Play Episode Listen Later Sep 21, 2021 35:26


    In the 2nd part of the phase separation series, Eugenio, Natalie, & Jatin sit down with Xiaolei Su, Qian Xiao, and Ceara McAtee continue their discussion.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: Phase separation in immune signalling | Nature Reviews Immunology

    Bep26 - Phase separation in Immune Signaling #1

    Play Episode Listen Later Sep 14, 2021 47:37


    In this Buddisode, Eugenio, Natalie, & Jatin sit down with Xiaolei Su, Qian Xiao, and Ceara McAtee from Yale cancer center at Yale university to discuss their latest review article published in Nature Immunology Reviews in July of 2021.Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast).Website: Antibuddies – Science Communication & Immunology (Antibuddies.org)Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCwSend us your queries/questions/suggestions at antibuddies1@gmail.com.Article of discussion: Phase separation in immune signalling | Nature Reviews Immunology

    Bep25 - Microbe-specific thymocyte development

    Play Episode Listen Later Aug 30, 2021 52:32


    In this Buddisode, Dara, Eugenio, Natalie, & Jatin sit down with Daniel from Gretchen Diehl's lab at Memorial Sloan Kettering Cancer Center, NY. The discussion entails their 2021 paper about the development of bacteria-specific T cells in the thymus of young mice and all the implications surrounding this discovery. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Join us on our monthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Article of discussion: Thymic development of gut-microbiota-specific T cells | Nature  

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