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The Agents Angle - The World's Premier Football (Soccer) Agent Show
In this episode of The Agents Angle, we explore a whirlwind of recent developments affecting football agents. Over 1,000 FIFA-licensed football agents appear to have been suspended, sparking questions about their future and any support that may be available to them. Joining us is the legendary football agent Barry Silkman, who brings over 30 years of experience as an agent and more than 300 professional games under his belt as a player. Silky shares fascinating insights into how players perceptions of agents have changed, the evolution of the agent's skillset, and his proudest transfer dealings, as well as how unexpected interventions and good fortune led to him becoming a football agent. We also unpack FIFA's recent introduction of new transfer windows, including the potential headaches these changes may cause for agents, especially those dealing with the Club World Cup. EMAIL : questions@theagentsangle.com SUPPORT THE SHOW via KoFi ====== SHOW RUNNING ORDER : (00:08) - Episode Introduction & Show Overview. > (01:05) - Eventful 10 Days Impacting on Football Agents. > (02:48) - Shocking Number of FIFA Agents Suspended. > (06:58) - Help for Suspended Agents? > (08:36) - Guest Interview : Barry Silkman. > (09:54) - Starting Out As a Football Agent. > (15:39) - Match of The Day Reunites Old Friends. > (21:08) - Players Perception of Agents Changed?. > (21:38) - Whats In A Modern-Day Agents 'Skillset'? > (22:39) - Why Agents May Lie & Cheat. > (27:59) - Biggest Changes in the World of the Football Agent. > (29:33) - Developing Good Relationships Across Football. > (31:57) - 'Bee in Their Bonnet' About Football Agents! > (36:53) - The Transfer Deal(s) That Make You Proud. > (38:06) - Club Chairman as 'Funny' as Groucho Marx. > (41:53) - Disappointing Parting, But No Regrets. > (42:57) - Proud of Many Player Clients (Friends). > (44:55) - Strangest Experiences as a Football Agent. > (46:57) - Zinedine Zidane was 'Useless'. > (47:18) - A Thank You - Simple, Priceless But Rare in Football. > (48:20) - Simple Advice to New Agents. > (49:55) - One Wish and the Downside of Football Data. > (51:37) - Same Game Different Words ....... Nonsense. > (53:49) - A True Football Man. > (55:17) - New FIFA Transfer Window(s) Affects Agents. > (59:01) - Headaches for Agents With CWC Transfer Windows. > (63:27) - Closing Remarks - Events & Announcements. > (65:12) - Disclaimer > ====== RELATED LINKS : FIFA Football Agent Register (3rd party) > The FA (England) - Licensed Agent Register > -- FIFA Transfer Window Tool > -- Rearrangement of African Football Agents (AFFAA) Workshop ====== FEATURED ARTICLES : FIFA announce new 10-day transfer window to avoid self-inflicted problems > FIFA proposes early transfer window for Club World Cup teams including Manchester City, Chelsea > -- FIFA launches interactive tool to keep fans on ball over global transfer windows > ===== SHOW LINKS: WEBSITE : www.theagentsangle.com LinkedIn Instagram Facebook Twitter (X) YouTube ====== CREDITS : Theme Music : Agent Red by Abbynoise Music from #Uppbeat : https://uppbeat.io/t/abbynoise/agent-red
Looking to rearrange your furniture to improve the 'Feng Shui'? Need a little help? Then call True Friends Moving Company (615 240 2811) today! Learn more at https://www.truefriendsmovingcompany.com/nashville/in-home-moving/ True Friends Moving Company City: Nashville Address: 700 East Old Hickory Blvd Website: https://www.truefriendsmovingcompany.com/ Phone: +1-615-988-9190 Email: info@truefriendsmoving.com
Nous voici (déjà) dans le 60e épisode de Quantum, le podcast de l'actualité quantique francophone. Événements France Quantum 2024 : les replays vidéo sont disponibles. Le séminaire Teratec TQCI sur le Benchmarking avait lieu à Reims les 4 et 5 juin. Voici les slides. La conférence Q-Expo les 11 et 12 juin d'Amsterdam organisée par le consortium QuiC Forum HQI au siège du CNRS le 13 juin AI Days à Brest le 19 juin L'École des Mines organisait le 26 juin une conférence sur les deeptechs avec un panel dédié aux technologies quantiques. Lindau les 1 et 2 juillet en Allemagne. On se prépare pour notre bain de prix Nobel puisque cet événement en regroupe 38 ! France C12 lève 18M€ Partenariat entre Pasqal et IBM Record chez PasqalContrôle précis du positionnement de 828 atomes dans plus de 2000 sites. La communication de Pasqal : https://www.pasqal.com/news/pasqal-exceeds-1000-atoms-in-quantum-processor/ Le papier scientifique : Rearrangement of single atoms in a 2000-site optical tweezers array at cryogenic temperatures by Grégoire Pichard, Adrien Signoles, Antoine Browaeys, Thierry Lahaye, Davide Dreon et al, arXiv, May 2024 (6 pages). Partenariat entre QuEra et QperfectL'annonce valorise cette startup française encore jeune dont l'émulateur quantique est très performant, à base de réseaux de tenseurs. Quandela inaugure une ligne de fabricationIl s'agit de l'extension de la ligne pilote de l'IPVF à Palaiseau avec l'achat de machines de production en propre par Quandela. Une humoriste du quantique, enfin !Célia Pelluet, Docteure en physique quantique est aussi humoriste. Elle était en déplacement aux Pays-Bas pour un #standup le 19 juin au @Panama Amsterdam pour faire rire avec des blagues scientifiques et sur son quotidien de chercheuse. International Quantinuum bat un nouveau record Quantinuum (USA) est passé de 32 à 56 qubits avec son QPU H2 et obtenait en juin une fidélité record de 99,84% pour des portes à deux qubits. The computational power of random quantum circuits in arbitrary geometries by Matthew DeCross, Marco Pistoia, et al, arXiv, June 2024 (36 pages).Entangling four logical qubits beyond break-even in a nonlocal code by Yifan Hong, Elijah Durso-Sabina, David Hayes, and Andrew Lucas, arXiv, June 2024 (6 pages). AQT teste l'approche 2DL'Autrichien AQT testait une puce 2D QCCD avec leur processus Quantum Spring Array (QSA), avec l'aide d'Infineon. Demonstration of two-dimensional connectivity for a scalable error-corrected ion-trap quantum processor architecture by Marco Valentini, Martin Rainer Blatt, Markus Müller, Thomas Monz, Philipp Schindler et al, arXiv, June 2024 (23 pages). Oxford IonicsLa startup UK a annoncé à la conférence DAMOP 2024 la réalisation de porte à deux qubits sur des ions piégés avec une fidélité de 99.97%. Duke Université et l'interconnexion longue distance d'ionsQ-CTRL La startup Australienne publiait un résultat de mitigation d'erreurs permettant de multiplier par 4 la taille d'un problème d'optimisation pouvant être résolu avec précision sur un QPU d'IBM de 127 qubits par rapport à ce que pourrait faire un Quantum Annealer de D-Wave. Quantum optimization using a 127-qubit gate-model IBM quantum computer can outperform quantum annealers for nontrivial binary optimization problems by Natasha Sachdeva, Gavin S. Harnett, Smarak Maity, Samuel Marsh, Yulun Wang, Adam Winick, Ryan Dougherty, Daniel Canuto, You Quan Chong, Michael Hush, Pranav S. Mundada, Christopher D. B. Bentley, Michael J. Biercuk, and Yuval Baum, arXiv, June 2024 (18 pages). A comment on comparing optimization on D-Wave and IBM quantum processors by Catherine C. McGeoch, Kevin Chern, Pau Farré, and Andrew K. King, D-Wave, arXiv, June 2024 (5 pages). Origin QuantumEn janvier 2024, la startup chinoise avait annoncé la mise en ligne de leur processeur Wukong à 72 qubits, utilisant 126 coupleurs accordables. Il aura fallu attendre mai et juin 2024 pour en connaitre leurs figures de mérite. Enabling Large-Scale and High-Precision Fluid Simulations on Near-Term Quantum Computers by Zhao-Yun Chen, Guo-Ping Guo et al, Origin Quantum, arXiv, June 2024 (31 pages). Demonstrating a universal logical gate set on a superconducting quantum processor by Jiaxuan Zhang, Guo-Ping Guo et al, Origin Quantum, CAS et al, arXiv, May 2024 (15 pages). Intel Pando Tree En juin, Intel présentait Pando Tree, une solution de multiplexage des signaux de contrôle de qubits entre les étages 4K et 10-20 mK. Intel's Millikelvin Quantum Research Control Chip Provides Denser Integration with Qubits, Intel, June 2024. Qblox lève 28M€https://www.linkedin.com/posts/european-quantum-industry-consortium-quic_quantum-quantumtechnology-quic-activity-7209550500042551296-1RLy
FDA Drug Information Soundcast in Clinical Oncology (D.I.S.C.O.)
Listen to a soundcast of the April 23, 2024, FDA approval of Ojemda (tovorafenib) for relapsed or refractory pediatric low-grade glioma harboring a BRAF fusion or rearrangement, or BRAF V600 mutation.
Événements · Voici les slides et vidéos de la journée Teratec/HQI du 24 avril 2024 sur le pack quantique Ile de France · Le 16 mai, workshop sur le calcul quantique organisé avec Le Lab Quantique à Station F slides. · France Quantum a eu lieu le 21 mai avec plus de 700 personnes, un record pour un événement quantique en France. · Vivatech avait lieu juste après avec une forte activité sur le stand HQI avec de nombreuses présentations ainsi que sur les stands du CNRS (Qperfect) et de la Région IDF (Alice&Bob). · Forum Teratec 2024 au Parc Floral les 29 et 30 mai. https://www.forumteratec.com/en Événements à venir :· TQCI benchmarking à Reims les 4 et 5 juin. Programme et inscriptions.· Q-Expo à Amsterdam, organisé par QuiC le 12 juin. https://www.linkedin.com/feed/update/urn:li:activity:7201492633590898688/. · Lindau Nobel Laureate Meetings en Allemagne,https://www.mediatheque.lindau-nobel.org/meetings/2024/programme France Deux annonces d'implantation en France, pour IBM et IQM à l'occasion de l'événement « Choose France » Investissement de 100M€ d'IQM en France et à Grenoble pour la création d'une ligne pilote industrielle de qubits supraconducteurs, montée avec le CEA-Leti et aussi Alice&Bob.https://www.meetiqm.com/newsroom/press-releases/iqm-to-build-a-fabrication-facility-in-france Investissement de 45M€ d'IBM en France pour la création d'un laboratoire sur le quantique, focalisé sur les outils logiciels. Il sera situé sur le plateau de Saclay dans le même bâtiment que leur laboratoire sur l'IA créé il y a quelques années. Annonce d'Alice&Bob le 15 mai 2024. Leur premier qubit de chat est maintenant disponible sur Google Cloud. https://www.datacenterdynamics.com/en/news/alice-bob-quantum-processor-available-on-google-cloud-marketplace/ Et un partenariat avec Riverlane pour la correction d'erreurs. https://www.hpcwire.com/off-the-wire/alice-bob-partners-with-riverlane-to-accelerate-quantum-error-correction/ · Annonce de Pasqal et Aramco. Aramco fait l'acquisition d'une machine de Pasqal de 200 qubits. L'équipe de Pasqal et de l'IOGS (Antoine Browaeys et Thierry Lahaye) démontrent une première mondiale avec le contrôle précis et le réarrangement de 828 atomes avec des pinces optiques contrôlées par un FPGA et grâce à l'emploi de deux lasers fonctionnant sur différentes longueurs d'ondes, à 813 et 818 nm. Rearrangement of single atoms in a 2000-site optical tweezers array at cryogenic temperatures by Grégoire Pichard, Desiree Lim, Etienne Bloch, Julien Vaneecloo, Lilian Bourachot, Gert-Jan Both, Guillaume Mériaux, Sylvain Dutartre, Richard Hostein, Julien Paris, Bruno Ximenez, Adrien Signoles, Antoine Browaeys, Thierry Lahaye, and Davide Dreon, arXiv, May 2024 (6 pages). · Annonce OVHcloud avec IBM Qiskithttps://fr.newsroom.ibm.com/OVHcloud-propose-le-kit-de-developpement-logiciel-Qiskit-dIBM-dans-le-cadre-de-son-portefeuille-de-notebooks-quantiques · Annonce SGPI avec l'AFNUM pour la vulgarisation du quantique, avec Pasqal, Cryptonext Security et TheGreenBow https://www.afnum.fr/wp-content/uploads/2024/05/CP-France-2030-quantique-28-mai-2024.pdf · Un Livre blanc sur le quantique du GIFAS qui montre l'appropriation des technologies quantiques par les industriels de l'aérospatial.https://www.gifas.fr/brochures?prod_pages%5BrefinementList%5D%5Btags.name%5D%5B0%5D=innovation International IBM et annonce d'évolutions de Qiskit. Notamment gestion de batches avec plusieurs jeux de circuits.https://www.ibm.com/quantum/qiskit?social_post=sf188632769&sf188632769=1 Quantum computing with Qiskit by Ali Javadi-Abhari, Matthew Treinish, Kevin Krsulich, Christopher J. Wood, Jake Lishman, Julien Gacon, Simon Martiel, Paul D. Nation, Lev S. Bishop, Andrew W. Cross, Blake R. Johnson, and Jay M. Gambetta, arXiv, May 2024 (16 pages). PsiQuantum fait encore des siennes, cette fois-ci à Chicago. https://thequantuminsider.com/2024/05/06/a-quantum-manhattan-project-in-chicago-media-reports-on-20-billion-quantum-computing-campus/ QCI (Yale) lève $25Mhttps://thequantuminsider.com/2024/05/29/quantum-circuits-inc-quietly-raises-26-5-million/ Un record dans les ions piégés en Chine Une équipe de recherche chinoise de l'Université de Tsinghua a démontré un contrôle record de 512 ions d'ytterbium (171Yb+) piégésformant un cristal de Wigner 2D dans un piège de Paul 3D monolithique. Divers Manifesto Women 4 Quantum piloté notamment par Pascale Senellart. https://women4quantum.eu/https://women4quantum.eu/wp-content/uploads/2024/05/w4q-manifesto-of-values.pdf
Today we had the pleasure of meeting Jenna Black, a luxury soul business and wealth mentor and host of the Woman of Wealth podcast. Her mission is to remind other's of their innate power and she believes that unlocking your higher self, activates higher wealth. During this conversation we talk about trusting in divine rearrangement, how to navigate the “in between” space when what you've been working towards hasn't manifested yet, and how to shift out of comparison, into inspiration. We also discuss that the antidote to uncertainty is self love, how motherhood can enhance your business and how money is a byproduct of following your truth. Jenna's Instagram Authentic Souls Instaram Authentic Souls Patreon
Moving services don't have to involve moving your belongings to a new home - sometimes, you just need help getting your furniture to a new room while you remodel. True Friends Moving Company meets ALL moving needs - call +1-615-988-9190 or click https://www.truefriendsmovingcompany.com/nashville/in-home-moving/ in Franklin! True Friends Moving Company City: Nashville Address: 700 East Old Hickory Blvd Website: https://www.truefriendsmovingcompany.com/ Phone: +1-615-988-9190 Email: info@truefriendsmoving.com
Hello Listeners! Di episode kali ini Wulan ngobrol-ngobrol dengan penyanyi dan penulis lagu yang sudah hampir 16 tahun berkarya di industri musik dan pada tahun 2024 ini merilis single lama dengan aransemen baru. Episode kali ini kita ditemani Adhitia Sofyan . Adhitia Sofyan, penyanyi dan penulis lagu yang sudah hampir 16 tahun berkarya di industri musik dan telah merilis karya sebanyak 9 album (termasuk mini album) studio, 2 album rekaman pertunjukan, 15 single, dan beberapa karya kolaborasi dengan beragam musisi yang dirilis sejak tahun 2010. Adhitia Sofyan pada Desember 2023 mengadakan pertunjukan di Jakarta dan tiket pertunjukannya terjual habis. Pada Tahun 2024 ini Adhitia Sofyan merilis lagu “Sesuatu di Jogja” dengan aransemen baru yang berkolaborasi dengan Bakpia Kukus Tugu Jogja. Adhitia Sofyan pernah merilis lagu Sesuatu di Jogja pada tahun 2017 terangkum dalam Extended Play (EP) bertajuk “8 Tahun”. Lagu “Sesuatu di Jogja” ciptaan Adhitia Sofyan telah menjadi single andalan para warga Yogyakarta dan khalayak yang memiliki kisah istimewa terhadap kota Jogja. Dalam kolaborasi karya Adhitia Sofyan ini berawal dari Bakpia Kukus Tugu Jogja yang mengakomodir rearansemen lagu Sesuatu di Jogja milik Adhitia Sofyan spesial untuk Bakpia Kukus Tugu Jogja guna memberikan keindahan dan kenangan dengan hadirnya Bakpia Kukus Tugu Jogja di setiap sudut Yogyakarta. Untuk Cerita lebih lengkapnya yuk dengarkan obrolan Langsung di Channel Podcast Bingkai Suara Season 5 di Spotify, Apple Podcast, Youtube atau kunjungi website kita di www.bingkaikarya.com
To kick off the new year, today we are joined by Neelkanth Chhaya who is a professor in India. Chhaya discusses forms and contingence of south Asian aesthetic theory, he is an open-minded and inquisitor thinker, and examines the ideas and interests and cross-references them.
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.23.550233v1?rss=1 Authors: Ikawa, K., Hiro, S., Kondo, S., Ohsawa, S., Sugimura, K. Abstract: Directional cell rearrangement is a critical process underlying correct tissue deformation during morphogenesis. Although the involvement of F-actin regulation in cell rearrangement has been established, the role and regulation of actin binding proteins (ABPs) in this process are not well understood. In this study, we investigated the function of Coronin-1, a WD-repeat actin-binding protein, in controlling directional cell rearrangement in the Drosophila pupal wing. Transgenic flies expressing Coronin-1-EGFP were generated using CRISPR-Cas9. We observed that Coronin-1 localizes at the reconnecting junction during cell rearrangement, which is dependent on actin interacting protein 1 (AIP1), an actin disassembler and a known regulator of wing cell rearrangement. Loss of Coronin-1 function reduces cell rearrangement directionality and hexagonal cell fraction. These results suggest that Coronin-1 promotes directional cell rearrangement via its interaction with AIP1, highlighting the role of ABPs in the complex process of morphogenesis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.22.550177v1?rss=1 Authors: Knapp, B., Willis, L., Gonzalez, C., Vashistha, H., Touma, J. J., Tikhonov, M., Ram, J., Salman, H., Elias, J. E., Huang, K. C. Abstract: The impact of temperature on growth is typically considered under heat- or cold-shock conditions that elicit specific regulation. In between, cellular growth rate varies according to the Arrhenius law of thermodynamics. Here, we use growth-rate dynamics during transitions between temperatures to discover how this behavior arises and what determines the temperature sensitivity of growth. Using a device that enables single-cell tracking across a wide range of temperatures, we show that bacteria exhibit a highly conserved, slow response to temperatures upshifts with a time scale of ~1.5 doublings at the higher temperature, regardless of initial/final temperature or nutrient source. We rule out transcriptional, translational, and membrane reconfiguration as potential mechanisms. Instead, we demonstrate that an autocatalytic enzyme network incorporating temperature-sensitive Michaelis-Menten kinetics recapitulates all temperature-shift dynamics, reveals that import dictates steady-state Arrhenius growth behavior, and successfully predicts alterations in the upshift response observed under simple-sugar or low-nutrient conditions or in fungi. These findings indicate that metabolome rearrangement dictates how temperature affects microbial growth. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Amazon's leaked document on ChatGPT, Japan's decision on AI training copyrights, and Israel's support for copyrighted works in machine learning. We also explore two research papers on end-to-end reinforcement learning for robotic mobile manipulation and benchmarking general conditional image similarity. Contact: sergi@earkind.com Timestamps: 00:34 Introduction 01:51 A leaked document of Amazon's ideas for using ChatGPT and AI at work lists 67 ways to take advantage of the ChatGPT boom 03:36 Japan Goes All In: Copyright Doesn't Apply To AI Training 04:49 Israel Ministry of Justice Issues Opinion Supporting the Use of Copyrighted Works for Machine Learning 06:38 Jim Fan on the future of Open Source Language Models 08:00 Fake sponsor 09:53 Galactic: Scaling End-to-End Reinforcement Learning for Rearrangement at 100k Steps-Per-Second 11:51 GeneCIS: A Benchmark for General Conditional Image Similarity 13:47 Outro
FDA Drug Information Soundcast in Clinical Oncology (D.I.S.C.O.)
Listen to a soundcast of the 8/24/22 and 8/26/22 FDA approvals of Imbruvica (ibrutinib) for pediatric patients with chronic graft versus host disease, including a new oral suspension, and Pemazyre (pemigatinib) for relapsed or refractory myeloid/lymphoid neoplasms with FGFR1 rearrangement.”
The identification of an actionable gene mutation or translocation in patients with cancer can give researchers a target for new drug therapies. One such mutation, found in some patients with non-small cell lung cancer (NSCLC), is anaplastic lymphoma kinase (ALK) gene rearrangement. However, the exact population of patients that present with ALK rearrangement has not been fully characterized. Identifying the subpopulation of patients who present with ALK rearrangement may lead to better overall treatment outcomes. Researchers—from University of Mississippi Medical Center, Roche Information Solutions, Roche Diagnostics Corporation, Genesis Research, and Houston Methodist Hospital—conducted a retrospective study of nearly 20,000 patients with advanced NSCLC (aNSCLC). The researchers assessed ALK rearrangement prevalence in the cohort overall and then categorized the data using patient characteristics. Their paper was published on the cover of Oncotarget's Volume 12, Issue 23, and entitled, “Anaplastic lymphoma kinase rearrangement prevalence in patients with advanced non-small cell lung cancer in the United States – retrospective real world data”. “We performed a retrospective study of a database to acquire real-world clinical data on the frequency of the translocation in a large pool of patients drawn primarily from community hospitals and practices.” Full blog - https://www.oncotarget.org/2021/11/10/new-study-alk-rearrangement-among-lung-cancer-patients/ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28114 DOI - https://doi.org/10.18632/oncotarget.28114 Full text - https://www.oncotarget.com/article/28114/text/ Correspondence to - Eric H. Bernicker - bernicker@houstonmethodist.org Keywords - ALK rearrangement, NSCLC, prevalence About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
CME credits: 1.00 Valid until: 24-08-2022 Claim your CME credit at https://reachmd.com/programs/cme/practicing-precision-alk-and-ros1-rearrangement-positive-nsclc-testing-targets-and-treatments/12757/ Capitalizing on the advances in identification of oncogenic driver mutations, genetic testing, and therapeutic approaches that target actionable mutations, targeted therapy is the current standard of care in NSCLC. The use of molecular testing and targeted therapies has yielded remarkable and practice-changing improvements for patients harboring these actionable mutations. The current availability of multiple targeted agents, such as second- and third-generation ALK and ROS1 tyrosine kinase inhibitors, some of which are approved for use both in first-line and subsequent lines of therapy, coupled with the presence of concomitant actionable mutations, can make selection of the appropriate targeted treatment for eligible patients complicated. This web-based, on-demand activity will feature an expert panel that will provide their interprofessional perspectives on the latest trends and emerging research regarding biomarker testing and evidence-based biomarker-guided targeted therapy for patients with NSCLC with ROS1 and ALK rearrangements.
CME credits: 1.00 Valid until: 24-08-2022 Claim your CME credit at https://reachmd.com/programs/cme/practicing-precision-alk-and-ros1-rearrangement-positive-nsclc-testing-targets-and-treatments/12757/ Capitalizing on the advances in identification of oncogenic driver mutations, genetic testing, and therapeutic approaches that target actionable mutations, targeted therapy is the current standard of care in NSCLC. The use of molecular testing and targeted therapies has yielded remarkable and practice-changing improvements for patients harboring these actionable mutations. The current availability of multiple targeted agents, such as second- and third-generation ALK and ROS1 tyrosine kinase inhibitors, some of which are approved for use both in first-line and subsequent lines of therapy, coupled with the presence of concomitant actionable mutations, can make selection of the appropriate targeted treatment for eligible patients complicated. This web-based, on-demand activity will feature an expert panel that will provide their interprofessional perspectives on the latest trends and emerging research regarding biomarker testing and evidence-based biomarker-guided targeted therapy for patients with NSCLC with ROS1 and ALK rearrangements.
In this video we'll be comparing all the reactions (SN1, SN2, E1, and E2). Timestamp: (0:00) - Intro (0:33) - Rate Law differences (1:12) - Base/Nucleophile differences (2:33) - Substrate differences (4:07) -Solvent differences (4:53) -Stereochemistry differences (6:02) -Rearrangement differences
In this video we'll be going over E1 reactions. (0:00) - Intro (1:41) - E1 Reaction - Stuck With Debt Reaction (2:20) - Zaitsev's Rule (3:27) -Rearrangement in E1 Reaction
In the 7th episode of Immunology 101 series, Dara, Eugenio, Jatin, and Natalie talk about the discovery of the T cell receptors, the mechanism of VDJ recombination in T cells, and comparison of VDJ recombination in T and B cells. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Sources: 1. Kuby Immunology
In the 6th episode of Immunology 101 series, Jatin and Natalie talk about the mechanism of VDJ recombination, its epigenetic aspect, and the steps that follow a successful heavy chain rearrangement. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies – Science Communication & Immunology (Antibuddies.org) Sources: 1. Kuby Immunology 2. Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase (nih.gov)
In their first episode, Eurich, Tom, and Xavier share their thoughts on Halo Infinite's art style changes and new details about the game's sandbox. Also, what do Craig the brute, dancing hunters, and Butterfinger candy bars all have in common? They're all in the Action Sack! Join The Assembly's very own three-man fireteam as they tackle turning Halo's fan-favorite playlist into a podcast. Original Halo Soundtrack composed by Martin O'Donnell & Michael Salvatori. Rearrangement by Jafet Meza, Séamus Bradd & Robbie Johnson.
In the 5th episode of Immunology 101 series, Eugenio, Jatin, Natalie, and Samriti talk about the how such an enormous antibody diversity is generated in B cells with limited antibody-coding genes. Jatin also tries to tell a joke which is not funny. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). Join us on our bimonthly journal club at our YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Sources: 1. Kuby Immunology 2. Fun fact sources: 10.1098/rstb.2014.0291 https://doi.org/10.1186/s13073-015-0243-2
Joe and Seb are joined by Karam to discuss the key issues affecting Fantasy Premier League managers in Double Gameweek 19. Just days after mulling over Blank Gameweek 18's issues, Joe, Seb and Karam are back again to take the next set of fixtures to task. Southampton's rearranged FA Cup clash with Shrewsbury has one of the biggest impacts on Gameweek 19. This means the Saints encounter with Leeds has been mothballed and both top-flight sides have just a single fixture. Where does this leave FPL managers looking to bench boost the likes of Patrick Bamford (£6.6m) and Che Adams (£6.0m)? Our trio take a look at the pros and cons of deploying this chip on single Gameweek assets. Meanwhile, the Everton and Villa game is off. So, there's a blank for the Toffees. But Villa still have a double as they play Manchester City then Newcastle, with the Magpies game now shoehorned into Gameweek 19's schedule. This leaves Villa assets viable options, however, it remains to be seen how the Covid-19 infection that has swept through the club has affected its first team. During the show Joe, Seb and Karam reveal their Gameweek 19 transfer plans and address further topics to help prepare FPL managers for this extended batch of games. Is this a good week to use the Triple Captain chip? Which defenders should be brought in? And can West Ham star Michail Antonio (£6.2m)'s legs make it through the week? As this latest episode was streamed during Thursday night's match between Arsenal and Crystal Palace emotions were running high regarding the Scoutcast crew's Gameweek 18 plans. They reveal how that set of limited fixtures impacted on their campaign. There's also fixtures to frisk, Seb attempts to describe a heat map and Joe has to eat humble pie regarding the Sheffield United defence. ━━━━━━━━━━━━━ Try Football Index - https://bit.ly/FootballIndexFPL 18+ https://www.begambleaware.org/ Full T&Cs - http://trade.footballindex.co.uk/moneybackguarantee ━━━━━━━━━━━━━
GRACEcast - Discussions with the Global Resource for Advancing Cancer Education
Dr. Caroline McCoach discusses ALK Rearrangement-Positive NSCLC and the leading first line treatment options for advanced NSCLC harboring an ALK rearrangement today
Timely. Artists this week include Errori In Partitura, Nghtcrwlr, and Siamgda.
Reflecting on the day of rearranged plans. --- Send in a voice message: https://anchor.fm/haiku-poet-101/message
A brand new iteration of The Sound Test LIVE! This time, I'm joined by Shelley Moncaster for fresh VGM playlists and all the old features, including:SFX ShowdownSongFightQuickfire Newsand a LIVE interview with Guinea Pig Parkour's Fat Bard!All future streams:https://www.youtube.com/channel/UC9jf-ef67-A3H79fLoRDtoQRequests and contact:https://twitter.com/GreenT128orhttps://www.facebook.com/thesoundtest/Original episodes of The Sound Test LIVE, with Dale Fowler, are available through Patreon:https://www.patreon.com/_secretcaveMore on Fat Bard:https://www.fatbard.com/https://twitter.com/Fat_BardThis week's playlist:Funkatronic (From “Toejam and Earl”) – Fat Bard [Nostalgia]Operation Birthday – Gareth Coker & Aeralie Brighton [The Mean Greens]Angel Island Zone (Act 1) – Rearrangement by Savaged Regime [Sonic the Hedgehog 3]Casino Night Zone (Unreleased) – Jun Senoue [Sonic 3D]Main Menu – Allister Brimble (originally composed by Randy Newman) [Toy Story]Hard Times – The Jetzons [Repurposed for Sonic the Hedgehog 3's “Ice Cap Zone”]Arcade Machine (Diegetic) – Noisia [Devil May Cry]Main Theme – Fat Bard [Guinea Pig Parkour]Baby Steps – Fat Bard [Blitz Breaker]Arpeggio Prism Power – Oleg NikitinTitle Screen – Jeroen Tel [Afterburner]Alleycat Blues – Mutsuhiko Izumi and/or Kozo Nakamura [Teenage Mutant Ninja Turtles IV: Turtles in Time]Hot Head Bop – David Wise (restored by Jammin' Sam Miller) [Donkey Kong Country 2]In the House In a Heartbeat – Alexei Omelchuk [Metro Exodus]Logic and Trick – Masakazu Sugimori and/or Naoto Tanaka [Phoenix Wright: Ace Attorney]Right Behind You – Mike Morasky (credited as “Valve Studio Orchestra”) [Team Fortress 2]Flyover – Gareth Coker [inMomentum]Flea Pit – Geoff & Tim Follin [Plok]JUDGMENT (Stage 1-1) – Takushi Hiyamuta, Yoshihiko Wada & S. Hosoi [Metal Slug 2]Merry Christmas Everybody – Mike Richmond (originally by Slade)It Must Have Been Love – Mike Richmond (originally by Roxette)Duckburg – Shigenori Kamiya [QuackShot]02 - ??? [Togepi's Great Adventure]MAIN THEME:Mahito Yokota, Toru Minegishi, Koji Kondo & Yasuake Iwata - World 8 [Super Mario 3D World]YouTube (Fat Bard Interview w/video)YouTube (Full Show)SpotifyiTunesStitcher
HIGH-end baker, recipe-maker and MOM to all Michelle Rabin of @momjeansprovisions changes NEWTS' mind on edibles with her smash-hit line of lifted treats. Listenup as NEWTS goes all-in on the best-tasting cookie of her life, and we talk to MOM about all things edibles: taste, dosing, how to get a good vibing high through the goodness of tasty treats. This one's a goodie!! #listenup #callyourmom
This week, a solid-state plane engine with no moving parts, and ‘mosaicism’ in brain cells. See acast.com/privacy for privacy and opt-out information.
Zac and Daniel are at it again! **FULL INFINITY WARS SPOILERS**After last week’s Phase one and two talk we’re looking at the most confusing and in depth look at Phase three!Got any different characters you want transplanted? Let us know at equippableallies@gmail.com
Zac and Daniel are looking at the MCU this week for the release of Infinity War. NO SPOILERSWhich character would be best in each MCU movie? There’s only one way to find out! Who would you like to see and where? Let us know at equippableallies@gmail.com
In the studio on an unusually warm night in February, we talk about how jealous we are of those that have their toys out. Cars we touch on include the Tesla Model X P100D, the Ford Expedition, Chrysler Pacifica, Toyota 4Runner TRD Pro, Acura RLX Sport-Hybrid. Jerry and Louis are back from Vietnam and talk about the oodles of cool things they saw there, and we learn what Kevin's infamous passengers thought of the Subaru Crosstrek and Impreza.
At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy
Tony Carr, University of Sussex, Falmer, speaks on "Mechanisms of replication-associated genome rearrangement". This movie has been recorded by ICGEB Trieste at "At the Intersection of DNA Replication and Genome Maintenance: 2016 - from Mechanism to Therapy" conference.
Dr. Ross Camidge, University of Colorado, addresses the question of whether to use a second generation ALK inhibitor as first line therapy or only after acquired resistance to crizotinib.
Dr. Ross Camidge, University of Colorado, addresses the question of whether to use a second generation ALK inhibitor as first line therapy or only after acquired resistance to crizotinib.
Dr. Ross Camidge, University of Colorado, addresses the question of whether to use a second generation ALK inhibitor as first line therapy or only after acquired resistance to crizotinib.
Dr. Ross Camidge, University of Colorado, discusses management of CNS progression for ALK-positive NSCLC including monitoring frequency and preferences between systemic and radiation therapy.
Dr. Ross Camidge, University of Colorado, discusses management of CNS progression for ALK-positive NSCLC including monitoring frequency and preferences between systemic and radiation therapy.
Dr. Ross Camidge, University of Colorado, discusses management of CNS progression for ALK-positive NSCLC including monitoring frequency and preferences between systemic and radiation therapy.
Dr. Ross Camidge, University of Colorado, describes the second generation ALK-inhibitors which provide good options for ALK-positive NSCLC patients who have developed acquired resistance to crizotinib.
Dr. Ross Camidge, University of Colorado, describes the second generation ALK-inhibitors which provide good options for ALK-positive NSCLC patients who have developed acquired resistance to crizotinib.
Dr. Ross Camidge, University of Colorado, describes the second generation ALK-inhibitors which provide good options for ALK-positive NSCLC patients who have developed acquired resistance to crizotinib.
Dr. Ross Camidge, University of Colorado, explains the preference for crizotinib rather than platinum doublet chemotherapy as first line treatment for patients with ALK or ROS1 rearrangements.
Dr. Ross Camidge, University of Colorado, explains the preference for crizotinib rather than platinum doublet chemotherapy as first line treatment for patients with ALK or ROS1 rearrangements.
Dr. Ross Camidge, University of Colorado, explains the preference for crizotinib rather than platinum doublet chemotherapy as first line treatment for patients with ALK or ROS1 rearrangements.
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