Podcasts about PubMed

It's been a month, in that time we've had a few important webinars, published lots of wonderful content & attended BIO in Boston this week. Thank you Virginie for going to BIO https://www.linkedin.com/posts/virginie-mcnamar_bio2025-theworldcantwait-raredisease-activity-7341849619028430848-I_FD    Ambry was awesome https://www.linkedin.com/posts/graglia_syngap1-ambryknowsgenes-activity-7336183874890231809-Beua    CURE SYNGAP1 CONNECT https://curesyngap1.org/curesyngap1connect/   CAMP4 Update - Hear it from them, in our US or EU Webinar.  US https://curesyngap1.org/resources/webinars/106-srf-us-know-about-asos-before-syngap1-clinical-trials-camp4-case-study/ EU https://curesyngap1.org/resources/webinars/107-srf-eu-know-about-asos-before-syngap1-clinical-trials-camp4-case-study/ Amlexanox and Cool Science Amlexanox (Repurposed Readthrough Drug) https://curesyngap1.org/resources/webinars/webinar-108-fortuity-pharma-repurposing-nonsense-mutations/ Cool Science https://curesyngap1.org/resources/webinars/webinar-109-linking-syngap1-and-human-specific-genes-srgap2b-c-that-control-the-tempo-of-synaptic-development/ Inaugural New Family Webinar Saturday June 28th, 2025, 9 AM Pacific https://curesyngap1.org/resources/webinars/syngap-research-fund-quarterly-webinar-new-syngap1-family-orientation/  Tuesday Sept. 9th, 2025, 5 PM Pacific also already scheduled! https://curesyngap1.org/resources/webinars/webinar-105-syngap-research-fund-quarterly-webinar-new-syngap1-family-orientation/   STUDIES - MATTER  ORTAS (need many, 27 signed up, 8 completed.) https://curesyngap1.org/resources/studies/ortas-observer-reported-toileting-abilities-survey/  BEACON (need 7) https://curesyngap1.org/resources/webinars/98-dreem-eeg-headband-to-assess-sleep-eeg-biomarkers-in-syngap1/   “Dear Families, This is a brief update on the Communication abilities in Children with Genetic Conditions study. The Communication abilities in Children with Genetic Conditions study collected parent-reported data on communication ability from 113 families and direct speech and language data from 33 children. Data collection has now closed and research reports are in preparation for the three most successfully recruited conditions; KBG syndrome, SYNGAP1-related disorder, and differences in MED13L. While the study was initially open to a wider group of single-gene conditions, it was only possible to recruit full data sets and large enough samples to produce high quality research reports for these three conditions. While not all of the data collected from families will be included in the research publications, all of the data provided by families has been extremely valuable to the study. Where permission has been given, anonymised data will serve as valuable pilot data to support future funding applications for research on relevant gene conditions. We thank all families for their valued time and participation in the project. Further updates will share our research reports as they become available. With best wishes, Harriet and the Communication abilities in Children with Genetic Conditions study team.”   PRESS  JJ in MD https://www.linkedin.com/posts/curesyngap1_syngap1-curesyngap1-activity-7331703029949267969-7AeK/  Stories #34 with Jo Ashline https://curesyngap1.org/podcasts/syngap1-stories/  Warriors Santiago, Axel and Issac! https://curesyngap1.org/syngap-warriors/  Cafe SYNGAP1 with Dina from NY https://curesyngap1.org/podcasts/cafe-syngap1/dina/  NL45 https://mailchi.mp/curesyngap1.org/make-a-splash-for-syngap1-awareness-45   FUNDRAISING Sprint Blog is Epic https://curesyngap1.org/blog/sprint4syngap-raises-over-200k-for-syngap1-in-5th-annual-fundraiser/ MDBR just happened Four team members raised $15,795 so far. Thanks to Heather Mestemaker, Justin Albrecht, Aaron Harding, and Alicia Harrison. https://cureSYNGAP1.org/MDBR Harper $5k match! https://donate.curesyngap1.org/campaign/694764/donate Liam https://donate.curesyngap1.org/campaign/696438/donate Story https://donate.curesyngap1.org/campaign/695981/donate   Thank you for your support, still matching! https://donate.curesyngap1.org/campaign/693597/donate   Pubmed is at 24 (so less than one a week…) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.2025-2025&timeline=expanded&sort=date&sort_order=asc   Harrison paper on early exons and inherited mutations is great… https://www.eurekalert.org/news-releases/1088068    Cunnane DCM is out and Ingo noticed! https://epilepsygenetics.blog/2025/06/20/revisiting-syngap1-through-a-disease-concept-model/  She spoke at SRF Conference https://www.youtube.com/watch?v=nXagMfYh9VA    SHARE BLOOD TO THE SRF BIOBANK AT CB! Read here for more information: https://curesyngap1.org/blog/fueling-research-syngap1-combinedbrain-biorepository-roadshow/    VOLUNTEER  Join us: https://curesyngap1.org/volunteer-with-srf/    SOCIAL MATTERS - 4,185 LinkedIn.  https://www.linkedin.com/company/curesyngap1/  - 1,380 YouTube.  https://www.youtube.com/@CureSYNGAP1    - 11,314 Twitter https://twitter.com/cureSYNGAP1  - 46k Insta https://www.instagram.com/curesyngap1/    NEWLY DIAGNOSED? New families have resources here! https://syngap.fund/Resources      Podcasts, give all of these a five star review! https://cureSYNGAP1.org/SRFApple   https://podcasts.apple.com/us/channel/syngap1-podcasts-by-srf/id6464522917    Episode 173 of #Syngap10  #Advocate #PatientAdvocacy #UnmetNeed #SYNGAP1 #SynGAP #SynGAProMMiS

Send us a Text Message (please include your email so we can respond!)Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025.Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/AJRCCM: https://www.atsjournals.org/doi/10.1164/rccm.202409-1727OCIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Chris Mirabile's journey into health and longevity began with a preteen's desire to impress girls during school fitness tests—but quickly evolved into something deeper. By age 12, Chris was reading Men's Health, refining his diet, and obsessing over performance, though he later realized much of his early approach to health was misguided. At 16, his life took a dramatic turn when he suffered a seizure during a school field trip and was diagnosed with a large brain tumor. Emergency brain surgery saved his life, but the experience left a lasting impression, igniting a relentless drive to understand human biology and wellness. ⁣ Though he studied finance and entrepreneurship at NYU, Chris immersed himself in scientific research, especially in bio-gerontology—the biology of aging. Long before it was a buzzword, he was poring over PubMed studies, using genetic testing tools, and analyzing his own DNA to uncover predispositions that might have contributed to his tumor. After early success and eventual failure with a social media startup, Chris doubled down on his passion for health optimization. He founded Novos, a company dedicated to slowing the aging process through science-backed supplements and nutrition, collaborating with researchers from institutions like Harvard, MIT, and the Salk Institute. ⁣ Today, Chris combines rigorous science with real-world application. He launched NovoScore, a daily supplement targeting all 12 known mechanisms of aging, and developed a science-forward meal replacement bar that emphasizes longevity-promoting ingredients over trendy marketing. Through Novos and his personal platform SlowMyAge, Chris educates others on optimizing biological age, drawing from cutting-edge research in omics sciences and data-driven health tracking. With over 10 million supplement doses taken and partnerships expanding, Chris's mission is clear: to empower people to live longer, healthier, and more vibrant lives through informed, evidence-based choices.

¿Cómo se construye una empresa biotecnológica de impacto global desde Argentina? ¿Qué pasa con las enfermedades que no interesan al mercado? ¿Y cómo se hace investigación puntera con recursos limitados?En este episodio hablamos con Linus Spatz, cofundador de Inmunova, una startup argentina nacida de la investigación básica que ha desarrollado un tratamiento innovador para el síndrome urémico hemolítico, una enfermedad pediátrica grave y desatendida.Conversamos sobre: Las dificultades (y fortalezas) de hacer ciencia desde Latinoamérica. Cómo se convierte una idea académica en una empresa con ensayos clínicos en Europa. Qué tipo de alianzas, modelos de negocio y estrategias hacen falta para llegar a fase 3 clínica desde el sur del mundo.Temas destacados El recorrido personal de Linus desde la biología básica hasta la biotecnología aplicada. El nacimiento de Inmunova y su evolución como startup más que como spin-off. Cómo se desarrolló la plataforma de presentación de antígenos que dio origen al tratamiento. La historia del desarrollo de un suero inmunológico contra el COVID-19 en plena pandemia. La complejidad y los desafíos regulatorios de los ensayos clínicos en enfermedades raras. El papel clave de los inversores con conocimiento científico (como el Grupo Insud). Reflexiones sobre el ecosistema emprendedor actual comparado con el de principios de los 2000.Frases clave “Quería quedarme en Argentina, criar a mis hijos aquí y aportar desde la ciencia.” “Hay que tener resiliencia: no todas las historias felices lo son desde el principio.” “Las patentes no son solo protección, también son seguridad para los inversores.” “Hoy hay un ecosistema emprendedor mucho más preparado en Latinoamérica.” “Hacer ciencia también es dudar de uno mismo cada día.”Recomendaciones del invitado El cisne negro y Antifrágil, de Nassim Taleb Engañados por el azar, también de Taleb Armas, gérmenes y acero, de Jared Diamond Obras de Daniel Kahneman sobre psicología y economía Libros de Yuval Noah HarariEnlaces y recursos

In this episode of The Moss Report, Ben Moss sits down with Dr. Ralph Moss to explore the real-world pros and cons of using artificial intelligence in cancer research and care. From AI-generated health advice to PubMed citations that don't exist, this honest conversation covers what AI tools are getting right—and where they can dangerously mislead. Dr. Moss shares the results of his own AI test across five major platforms, exposing their strengths and surprising failures. Whether you're a cancer patient, caregiver, or simply curious about how AI is shaping the future of medicine, this episode is essential listening. Links and Resources:

Send us a textAnswer a few questions to help me improve this podcast here.We all want to live long and well—but how do we determine how many good years we have ahead?In this episode of Live Long and Well with Dr. Bobby, we explore how to estimate both our total lifespan and the number of years we can expect to remain active and pain-free. Dr. Bobby reflects on personal experiences, emerging science, and time-tested frameworks to help you reframe your health trajectory with clarity and motivation. While we may not find exact answers, the tools and thought experiments shared in this conversation can shape the way we live now—and influence how we plan for the future.We begin with why this topic matters, touching on personal stories of loss, aging milestones, and medical advancements. Then we move into three frameworks: how many years you might live (using tools from actuarial tables to cardiovascular risk calculators), how many of those years might be "good," and the wildcard of unpredictable events.The simplest predictor comes from actuarial life tables, which estimate life expectancy by age and sex. A 55-year-old man today might expect to live to 79; a woman to 82. More advanced tools include the Framingham Risk Score, which factors in cholesterol, blood pressure, smoking status, and diabetes to estimate 10-year cardiovascular risk. Research suggests that sharing these risk scores can lead to behavior changes, as shown in this meta-analysis of 28 studies and preliminary evidence of outcome improvements.On the genetics side, polygenic risk scores offer a glimpse into inherited risks, though they remain research tools for now (Nature study). More accessible are tests for specific genes like APOE4, which increases the risk of dementia (PubMed).Beyond numbers, simple physical tests can offer insight. The Brazilian sit-stand test links mobility with mortality risk: fewer than 8 points doubles your six-year mortality risk. Grip strength, too, is a strong predictor of all-cause mortality across 17 countries (PubMed).While biologic clocks based on DNA methylation are generating buzz, their utility remains limited due to variability between samples and testing methods (Nature Communications).When it comes to estimating “good” years—those lived free from major pain or disability—the data are sparse. Some disease-specific tools (e.g., for MS or dementia progression) exist, but there's no universal actuarial equivalent. However, we know muscle mass and aerobic capacity decline predictably with age—1–2% muscle loss per year and a 10% drop in aerobic fitness per decade (OUP Journal). Predicting your future function can begin with assessing how far you can walk, whether stairs leave you breathless, or how your weight and strength compare to a decade ago.Finally, we can't forget unpredictable events: the odds of a serious fall increase significantly after 65, and vision or hearing loss multiplies that risk (NCOA). Building physical resilience now can reduce these odds—see

Is soy actually good for us? Have we been lied to about soy and phytoestrogens?Today I'm sharing some shocking studies on the health benefits of soy and other foods containing phytoestrogens. Soy may not be for everyone—including me (I share why in this episode)—however, it may actually help several women (and men!) in different ways. Here's what the science says… PLUS… foods that contain phytoestrogens beyond soy. STUDIES: This PubMed study found that Asian-Americans who ate tofu had a reduced risk of developing breast cancer. The more tofu they ate, the lower their risk. http://www.ncbi.nlm.nih.gov/pubmed/8922298  Here are 11 PubMed studies highlighting how soy benefits our bones: http://www.ncbi.nlm.nih.gov/pubmed/19367115 http://www.ncbi.nlm.nih.gov/pubmed/11095177 http://www.ncbi.nlm.nih.gov/pubmed/16763748 http://www.ncbi.nlm.nih.gov/pubmed/14557449 http://www.ncbi.nlm.nih.gov/pubmed/12920508 http://www.ncbi.nlm.nih.gov/pubmed/15018488 http://www.ncbi.nlm.nih.gov/pubmed/10757817 http://www.ncbi.nlm.nih.gov/pubmed/15702593 http://www.ncbi.nlm.nih.gov/pubmed/10479216 http://www.ncbi.nlm.nih.gov/pubmed/15309425 http://www.ncbi.nlm.nih.gov/pubmed/10966908 It appears that just taking a daily pill containing the isoflavone genistein may be enough to reap some of soy's bone density benefits:http://www.ncbi.nlm.nih.gov/pubmed/17577003 People in Asia consume much, much, much more soy than those in the West:http://www.smart-publications.com/cancer/daidzein.php Interestingly, men may benefit slightly more than women from eating foods rich in phytoestrogens. These compounds are linked to reduced risks of cancer, cardiovascular disease, cerebrovascular disease, and several other conditions: http://jama.ama-assn.org/cgi/content-nw/full/294/12/1493/JOC50096T5 http://jn.nutrition.org/cgi/content/full/136/12/3046 http://content.onlinejacc.org/cgi/content/full/35/6/1403 As always, if you have any questions for the show please email us at digestthispod@gmail.com.  And if you like this show, please share it, rate it, review it and subscribe to it on your favorite podcast app.  Sponsored By: Armra | Use code DIGEST for 15% off at tryarmra.com/digest  Fatty15 | For 15% off the starter kit go to fatty15.com/digest Bethany's Pantry | Go to bethanyspantry.com and use code PODCAST10 for 10$  Check Out Bethany: Bethany's Instagram: @lilsipper YouTube Bethany's Website Discounts & My Favorite Products My Digestive Support Protein Powder Gut Reset Book  Get my Newsletters (Friday Finds)

Methylene blue is widely marketed over the counter to the general public as well as to the natural health, health freedom, and freedom communities, often on the internet. It is flooding America.   Some sellers are touting methylene blue as a “miracle” tonic that improves “cognitive function”1 and boosts energy to previously unimagined heights. Some have given live demonstrations on TV and podcasts demonstrating how the oral form hyperactivates some people within 35 minutes of the first dose — a typical stimulant drug rush — which is actually a danger signal for potentially activating them into a dangerous manic episode during future exposures or even more deadly outcomes.   Read the full article here: Methylene Blue is highly neurotoxic to your brain and mind   In reality, methylene blue is a lethal neurotoxin, a poison to the brain. It has the same basic chemical composition and harmful clinical effects as the oldest and most neurotoxic “antidepressants,” the monoamine oxidase inhibitors (MAOIs). It also has similarities to the neurotoxic phenothiazine “antipsychotic” drugs, including the original Thorazine (chlorpromazine), but methylene blue is more stimulating or activating.   Methylene blue is not a miraculous new discovery. It is the opposite. Created in 1876 in a lab — it is the oldest manmade chemical to be used in medicine. But in well over a century, methylene blue has never been FDA-approved for psychiatric purposes. Later, its chemical structure was modified in labs for creating many of the earliest, most neurotoxic psychiatric drugs.   Methylene blue suppresses or destroys forms of the enzyme monoamine oxidase that are used by the brain for controlling or modulating four different powerful neurotransmitters — serotonin, dopamine, norepinephrine, and epinephrine. In short, by crushing monoamine oxidase, methylene blue causes overstimulation of four of the brain's major neurotransmitters, all of which profoundly impact the mind.   After the FDA was created in 1906, methylene blue was grandfathered into the market by the agency as an obscure antidote for methemoglobinemia, but it must be emphasized that the FDA has never tested the safety of methylene blue for any purpose. Furthermore, the FDA, based on its adverse reporting system and scientific reports, has published serious warnings about potentially lethal adverse reactions from methylene blue, especially when combined with numerous other drugs.2   The first MAOIs used as depressants were derived from methylene blue, and they turned out to be so toxic that the first two were quickly taken off the market by the FDA. One caused lethal liver disease, and the other caused hypertensive crises. Methylene blue is known to impair liver function tests and to cause hypertensive crises. Early on, all MAOIs were removed for a while from the international list of approved drugs. Please go to this endnote in my report  for a list of historical and scientific studies about the extraordinary history and the nature of methylene blue and the other MAOIs.3   Psychiatry and the psychopharmaceutical complex are so driven to impose neurotoxins upon our brains ⎯ some MAOI antidepressants remain on the market today. FDA Full Prescribing Information for the existing MAOI antidepressants, readily available online,4 provides quick access to the kinds of adverse effects caused by methylene blue. These FDA documents also provide lists of the foods and of some of the many, many drugs you cannot take with MAOIs, like methylene blue, without risking death from serotonin syndrome or a hypertensive crisis.   Meanwhile, all of America is being made a market for the original mother of them all, methylene blue, without requiring a prescription, with bizarrely distorted claims, and with unlimited supplies handed out as easily as a new caffeinated soda.   All of the three approved MAOIs, as well as methylene blue, carry repeated warnings at the FDA and in the scientific community about causing the two potentially crippling and lethal outcomes, serotonin syndrome and malignant hypertension (see below). These potentially lethal outcomes, as with all MAOIs, become much more serious and higher risk when methylene blue is taken with certain foods such as cheese and bananas, or literally with so many other drugs that it is impossible to memorize them or to keep track of them.   Here is one version of a short summary of the long list of dangerous interactions between MAOIs, including methylene blue, and other drugs and foods, taken from Goodman and Gilman's The Pharmacological Basis of Therapeutics (2018, p. 274):   Monoamine Oxidase Inhibitors   Serotonin syndrome is the most serious drug interaction for the MAOIs (see Adverse Effects). The most common cause of serotonin syndrome in patients taking MAOIs is the accidental coadministration of a SHT reuptake-inhibiting antidepressant or tryptophan. Other serious drug interactions include those with meperidine and tramadol. MAOIs also interact with sympathomimetics such as pseudoephedrine, phenylephrine, oxymetazoline, phenylpropanolamine, and amphetamine; these are commonly found in cold and allergy medication and diet aids and should be avoided by patients taking MAOIs. Likewise, patients on MAOIs must avoid foods containing high levels of tyramine: soy products, dried meats and sausages, dried fruits, home-brewed and tap beers, red wine, pickled or fermented foods, and aged cheeses.   I am presenting this detailed summary in the hope of gaining the immediate attention of people and businesses who are promoting methylene blue and anyone who is unfortunately taking it. Please share this summary or the entire document as widely as possible and with proper attribution.   An extensive article follows, detailing my professional experience in the arena of psychopharmacology. It includes a lengthy scientific analysis with more than two dozen endnotes containing an even greater number of scientific citations.   Read the full article here: Methylene Blue is highly neurotoxic to your brain and mind   End Notes   1 All stimulants from caffeine to Ritalin (methylphenidate) and on to methamphetamine and cocaine, and including MAOIs, can produce subjective feelings of improved concentration or memory, and some short-term studies show a brief improvement. This is caused by obsessive-compulsive mental focusing and is driven by a narrowing of general awareness and judgment.  No FDA-approved stimulants, for example, have been proven to help cognition or academic performance, and all harm the brain long-term.  Here is a study that is negligent in its claims and its lack of warnings about methylene blue that may have encouraged the current epidemic use: https://psychiatryonline.org/doi/full/10.1176/appi.pn.2016.pp8a5 I have researched these issues in multiple scientific papers and books, including Brain-Disabling Treatments in Psychiatry: Drugs, Electroshock, and the Psychopharmaceutical Complex, second edition (2008).  For an easily accessible, comprehensive look at stimulant drug effects, also see my free resource center on children and stimulant medications: https://breggin.com/Childrens-Resources-Center   2 Drug Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications | FDA and FDA Drug Safety Communication: Updated information about the drug interaction between methylene blue and Drug Safety Podcasts > FDA Drug Safety Podcast for Healthcare Professionals: Updated information about the drug interaction between methylene blue and serotonergic psychiatric medications (methylthioninium chloride) and serotonergic psychiatric medications | FDA and much more comprehensive coverage of methylene blue adverse effects with special warnings for professionals can be found at Methylene Blue Monograph for Professionals – Drugs.com   3 Half_a_century_of_antidepressant_drugs_-20151101-21548-vmvosk-libre.pdf. Also see Methylene Blue: The Long and Winding Road From Stain to Brain: Part 2 – PubMed and Methylene Blue in the Treatment of Neuropsychiatric Disorders – PubMed; and Iproniazid | Antidepressant, Monoamine Oxidase Inhibitor & Mental Health | Britannica; Methylene Blue: The Long and Winding Road From Stain to Brain: Part 2 – PubMed; Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today – PubMed. These cover the fascinating history of MAOIs and Methylene Blue.    4 The currently approved MAOI antidepressants are phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldpryl, Emsam, Zelapar)), and isocarboxazid (Marplan).     ______   Learn more about Dr. Peter Breggin's work: https://breggin.com/   See more from Dr. Breggin's long history of being a reformer in psychiatry: https://breggin.com/Psychiatry-as-an-Instrument-of-Social-and-Political-Control   Psychiatric Drug Withdrawal, the how-to manual @ https://breggin.com/a-guide-for-prescribers-therapists-patients-and-their-families/   Get a copy of Dr. Breggin's latest book: WHO ARE THE “THEY” - THESE GLOBAL PREDATORS? WHAT ARE THEIR MOTIVES AND THEIR PLANS FOR US? HOW CAN WE DEFEND AGAINST THEM? Covid-19 and the Global Predators: We are the Prey Get a copy: https://www.wearetheprey.com/   “No other book so comprehensively covers the details of COVID-19 criminal conduct as well as its origins in a network of global predators seeking wealth and power at the expense of human freedom and prosperity, under cover of false public health policies.”   ~ Robert F Kennedy, Jr Author of #1 bestseller The Real Anthony Fauci and Founder, Chairman and Chief Legal Counsel for Children's Health Defense.

00:00 Unpopular hair truths no one talks about but everyoneneeds to hear00:41 Unpopular hair truth #1 “Effortless” is a vibe, not areality02:21 Unpopular hair truth #2 Peri-menopause and menopausecan change your hair. It's not in your head and you're not doing anythingwrong.03:53 Unpopular hair truth #3 Seasonal shedding is normal(esp. in the summer)04:02 The three phases of hair growth05:57 Unpopular hair truth #4 The goal is to LOVE your hairat every age of your life.06:46 Hairstylists walk our clients through each phase oflife07:03 Unpopular hair truth #5 Hair is deeply emotional.08:55 Unpopular hair truth #6 A good shower filter will notsave your $300 color from cheap shampoo10:20 The issue with online product quizzes and AIrecommendations (most women don't know what hair they have)11:30 Unpopular hair truth #7 Only 10% of your hair healthis from what happens in the salon. 90% is what happens at home.13:36 Unpopular hair truth #8 Natural color still needsmaintenance, natural texture still needs effort.15:11 Unpopular hair truth #9 You don't have to follow societalbeauty “rules”DePolo, Jaime. (30 January, 2025). Menopausal Hair Changes. Breastcancer.org. https://www.breastcancer.org/treatment-side-effects/menopause/hair-changesKunz, Michael. (29 April, 2009). Seasonality of hair shedding in healthy women complaining of hair loss. Pubmed. https://pubmed.ncbi.nlm.nih.gov/19407435/10 Hair Care Habits that can Damage Your Hair. American Academy of Dermatology. https://www.aad.org/public/everyday-care/hair-scalp-care/hair/habits-that-damage-hair

Identifying and Evaluating Young Children with Developmental Central Hypotonia: An Overview of Systematic Reviews and ToolsChildren with developmental central hypotonia have reduced muscle tone secondary to non-progressive damage to the brain or brainstem. Children may have transient delays, mild or global functional impairments, and the lack of a clear understanding of this diagnosis makes evaluating appropriate interventions challenging. This overview aimed to systematically describe the best available evidence for tools to identify and evaluate children with developmental central hypotonia aged 2 months to 6 years. A systematic review of systematic reviews or syntheses was conducted with electronic searches in PubMed, Medline, CINAHL, Scopus, Cochrane Database of Systematic Reviews, Google Scholar, and PEDro and supplemented with hand-searching. Methodological quality and risk-of-bias were evaluated, and included reviews and tools were compared and contrasted. Three systematic reviews, an evidence-based clinical assessment algorithm, three measurement protocols, and two additional measurement tools were identified. For children aged 2 months to 2 years, the Hammersmith Infant Neurological Examination has the strongest measurement properties and contains a subset of items that may be useful for quantifying the severity of hypotonia. For children aged 2-6 years, a clinical algorithm and individual tools provide guidance. Further research is required to develop and validate all evaluative tools for children with developmental central hypotonia.

They may not have backbones, but invertebrates are the unsung heroes of the natural world, shaping landscapes, driving ecosystems, and even influencing the behaviour of top predators.In this episode, we journey into their fascinating and often overlooked world. We explore how termites engineer entire ecosystems, how ant behaviour can influence lion hunting patterns, and why a specific rainforest bee is the key to every Brazil nut you've ever eaten.While many invertebrates are now in decline, it's not all bad news. We share some hopeful conservation stories, organisations working hard to protect our invertebrate populations, and highlight simple ways we can all help support these vital animals.Researching this episode took us down all sorts of unexpected rabbit holes, something you'll definitely hear reflected in the conversation.We hope you enjoy listening What's your favourite invertebrate fact, story, or encounter? Come share it with us over on Instagram. We'd love to hear from you @thebirdybugpod.Get in touchDon't forget to follow The Birdy Bug Pod over on Instagram. And please do feel free to contact us with any questions, feedback, comments, or just to say hi!Follow us @thebirdybugpodLinks'We cannot survive without insects' – DW – 06/22/2018How loud is YOUR penis?! The waterboatman and his mighty member!Stream Lesser Water Boatman, the loudest underwater insect by terranova | Listen online for free on SoundCloudFigs & Wasps | How Are Figs Pollinated? | FoodUnfoldedLetting grass grow long boosts butterfly numbers, UK study proves | Butterflies | The GuardianEcological feedbacks. Termite mounds can increase the robustness of dryland ecosystems to climatic change - PubMed

BUFFALO, NY - May 14, 2025 – A new #review paper was #published in Volume 16 of Oncotarget on May 9, 2025, titled “Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis." A comprehensive study, led by first authors Rahaf Alchazal from Yarmouk University and Khaled J. Zaitoun from Johns Hopkins University School of Medicine and Jordan University of Science and Technology, examined the potential link between blood type and breast cancer. The research team conducted a systematic review and meta-analysis of 29 previously published studies, involving more than 13,000 breast cancer patients and over 717,000 controls. “Researchers searched for studies on breast cancer patients and ABO blood groups across four major databases: PubMed, Scopus, Web of Science, and Google.“ Breast cancer is the most common cancer among women worldwide. Identifying risk factors is vital for early detection and prevention. While many studies have explored lifestyle and genetic causes, this analysis focused on the ABO blood group system. By pooling global data, the researchers found that blood type A was the most common among breast cancer patients and was significantly associated with an 18% increased risk compared to type O. The study did not find a significant association between breast cancer and blood types B, AB, or Rh factor. Although the results do not prove causation, they point to a biological pattern worth further investigation. Blood group antigens are proteins found on the surface of cells, including breast tissue. These molecules may influence how cancer develops and spreads by interacting with the immune system or affecting cell behavior. This meta-analysis is the most extensive review to date on this topic, based on studies conducted across Asia, Europe, Africa, and the Americas. While previous research found unclear conclusions, this large-scale evaluation provides stronger evidence for a possible connection between blood type A and breast cancer risk. Researchers note that regional differences, genetic diversity, and study quality may affect individual results. Nevertheless, the overall trend supports considering blood type A as a potential risk marker. This insight could help shape screening guidelines, encouraging earlier or more frequent checkups for women with this blood type. Further research is needed to understand why blood type A may play a role in cancer development. Future studies may explore genetic mechanisms, immune responses, and other biological pathways. These efforts could lead the way for more personalized cancer prevention and care strategies. DOI - https://doi.org/10.18632/oncotarget.28718 Correspondence to - Khaled J. Zaitoun - kzaitou1@jh.edu Video short - https://www.youtube.com/watch?v=BQFVtreaetI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28718 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, breast cancer, cancer risk factors, blood group antigens, tumor To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

DITCH YOUR DOCTOR! https://www.livelongerformula.com/wam Get a natural health practitioner and work with Christian Yordanov! Mention WAM and get a FREE masterclass! You will ALSO get a FREE metabolic function assessment! HELP SUPPORT US AS WE DOCUMENT HISTORY HERE: https://gogetfunding.com/help-wam-cover-history/ GET NON-MRNA FREEZE DRIED MEAT HERE: https://wambeef.com/ Use code WAMBEEF to save 20%! GET HEIRLOOM SEEDS & NON GMO SURVIVAL FOOD HERE: https://heavensharvest.com/ USE Code WAM to save 5% plus free shipping! GET YOUR APRICOT SEEDS at the life-saving Richardson Nutritional Center HERE: https://rncstore.com/r?id=bg8qc1 Use code JOSH to save money! Josh Sigurdson reports on a landmark study out of the prestigious International Journal Of Preventative Medicine in March which studies 85 million people and puts together 15 studies including 11 controlled studies and 4 studies without a control group to give a more broad view. The studies include those from PubMed, Web of Science, Scopus, Cochrane Library and Google Scholar until October 22nd, 2023. The studies show an enormous increase in not just overall death rates but also in specific ailments including heart attack, stroke and arrhythmia, specifically showing massive increases by Pfizer's BNT162b2 vaccines and AstraZeneca's ChAdOx1 vaccines but also looks at Moderna. There are increases in things like arrhythmia that reach as high as 711% following injection and multiple cases of increases in coronary artery disease, myocardial infarction and stroke above 200%. The most common things one dies from are seeing massive increases only after being vaxxed. This is an indictment on the injections and something we already knew. The difference is that we are seeing this study with 85 million people involved and when combined with 3 other studies, we actually see a combined total of 184 million people involved overall. As the governments of the world continue to push Bird Flu after the Covid hoax and go after the animals while trying to force inject us and even RFK Jr is promoting Measles MMR vaccines while not taking the mRNA Covid Vaccines out of the childhood vaccine schedule, expect the continuation of fearmongering and further restrictions going into the future. This is a eugenics operation after all. Prepare yourselves outside of the pharma system as well as remove yourself from depending on the banks, grocery stores and government. Stay tuned for more from WAM! Get local, healthy, pasture raised meat delivered to your door here: https://wildpastures.com/promos/save-20-for-life/bonus15?oid=6&affid=321 USE THE LINK & get 20% off for life and $15 off your first box! SIGN UP FOR HOMESTEADING COURSES NOW: https://freedomfarmers.com/link/17150/ Get Prepared & Start The Move Towards Real Independence With Curtis Stone's Courses! GET YOUR WAV WATCH HERE: https://buy.wavwatch.com/WAM Use Code WAM to save $100 and purchase amazing healing frequency technology! GET ORGANIC CHAGA MUSHROOMS HERE: https://alaskachaga.com/wam Use code WAM to save money! See shop for a wide range of products! GET AMAZING MEAT STICKS HERE: https://4db671-1e.myshopify.com/discount/WAM?rfsn=8425577.918561&utm_source=refersion&utm_medium=affiliate&utm_campaign=8425577.918561 USE CODE WAM TO SAVE MONEY! GET YOUR FREEDOM KELLY KETTLE KIT HERE: https://patriotprepared.com/shop/freedom-kettle/ Use Code WAM and enjoy many solutions for the outdoors in the face of the impending reset! BUY GOLD HERE: https://firstnationalbullion.com/schedule-consult/ PayPal: ancientwonderstelevision@gmail.com FIND OUR CoinTree page here: https://cointr.ee/joshsigurdson JOIN US on SubscribeStar here: https://www.subscribestar.com/world-alternative-media For subscriber only content! Pledge here! Just a dollar a month can help us alive! https://www.patreon.com/user?u=2652072&ty=h&u=2652072 BITCOIN ADDRESS: 18d1WEnYYhBRgZVbeyLr6UfiJhrQygcgNU World Alternative Media 2025

Chris Mirabile's journey to achieving a biological age 13.6 years younger than his chronological age is not a tale of luck but of deliberate action and deep scientific understanding. His transformation extends beyond mere youthful appearance. He's aging 31% slower than average.  This remarkable feat is rooted in intense self-education and a disciplined lifestyle geared towards optimizing health at a molecular level. His story began at 16, when a severe seizure led to the discovery and surgical removal of a brain tumor. This life-altering event shifted his focus from basic fitness to a profound understanding of human biology and aging. A Scientific Awakening Chris transitioned from merely wanting to look fit to optimizing his long-term well-being. Utilizing academic databases like PubMed, he educated himself on the science of aging and its biological processes. The "Hallmarks of Aging" paper was a turning point, revealing aging not as inevitable, but as a series of manageable biological processes. This realization drove him to a proactive approach to health, aiming to manage and slow aging. Targeting the 12 Aging Mechanisms Today, Chris's lifestyle and biotechnology company NOVOS are structured around the 12 mechanisms that drive aging. Here's a quick look at how he addresses each: Mitochondrial Dysfunction: Enhanced through exercise and specific nutrients. Cellular Senescence: Reduced via supplements and fasting. Loss of Proteostasis: Improved by autophagy-activating practices. Intercellular Communication: Maintained by limiting inflammation. Genomic Instability: Addressed with hormetic stress like cold exposure. Epigenetic Alterations: Supported with lifestyle changes. Telomere Shortening: Minimized with diet and recovery. Deregulated Nutrient Sensing: Balanced through feeding/fasting cycles. Stem Cell Exhaustion: Preserved with low-inflammation living. Inflammaging: Reduced with anti-inflammatory strategies. Disabled Autophagy: Enhanced by intermittent fasting and polyphenols. Gut Dysbiosis: Improved through diet diversity and probiotics. By targeting these mechanisms, Chris actively works to slow and even reverse biological aging. Lifestyle as Medicine For Chris, lifestyle is the foundation of health optimization. His daily routine reflects the principles he has gleaned from his research. His diet follows a Mediterranean model, emphasizing whole plants, healthy fats, and moderate protein. He integrates periodic fasting to optimize longevity pathways. His exercise regimen is multifaceted, combining resistance training four times a week, cardio three times a week, and daily walking. Sleep is prioritized, with seven to nine hours tracked via the Oura Ring. Stress management is crucial, as well as incorporating journaling, meditation, and reframing challenges as opportunities for growth. He also utilizes specific supplements, such as NOVOS Core, developed from biotech research to support the hallmarks of aging. NOVOS: Measuring and Managing Aging NOVOS embodies Chris's belief in the scientific manageability of aging. The company offers precise formulations like NOVOS Core, which has shown lifespan extension in animal studies, and biological age testing via epigenetic analysis. The NOVOS Life app provides digital guidance, using AI to generate personalized longevity plans and estimate biological age, making longevity accessible and manageable. In this podcast, you'll learn... How Chris Mirabile reduced his biological age by 13.6 years and its importance. The 12 aging mechanisms Chris targets with NOVOS. Practical lifestyle adjustments for longevity, including diet, exercise, and stress management. The role of scientific innovation in managing aging. How to reframe challenges and use adversity for personal growth. EPISODE RESOURCES: Website LinkedIn Instagram xCom

Send us a Text Message (please include your email so we can respond!)Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025.Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Welcome to Episode 45 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 45 of “The 2 View” – All things toxicology: the intoxicated patient, propranolol overdose and suicide, snake bites, and a special guest. Segment 1 – The intoxicated patient Kaufman J, Fitzpatrick P, Tosif S, et al. Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial. BMJ. The BMJ. Published April 7, 2017. https://www.bmj.com/content/357/bmj.j1341 Kraaijvanger N, Raven W, van Dijken T, Gresnigt F. The PIRATE mnemonic: providing a structured approach in the care for intoxicated patients at the emergency department. Int J Emerg Med. Educational Advances in Emergency Medicine. BMC: Part of Springer Nature. Published March 1, 2024 https://intjem.biomedcentral.com/articles/10.1186/s12245-024-00606-4 Thiessen P. A simple new technique for collecting urine in infants. Thischangedmypractice.com. The University of British Columbia. Faculty of Medicine: This Changed My Practice (TCMP) by UBC CPD. Published November 18, 2015. https://thischangedmypractice.com/new-technique-for-collecting-urine-in-infants/ Van Oyen A, Barney N, Grabinski Z, et al. Urine Toxicology Test for Children With Altered Mental Status. Aap.org. Pediatrics. Case Reports. American Academy of Pediatrics: Dedicated to the Health of All Children. Published October 6, 2023. https://publications.aap.org/pediatrics/article/152/5/e2022060861/194346/Urine-Toxicology-Test-for-Children-With-Altered?autologincheck=redirected Segment 2 – Propranolol overdose and suicide Khalid MM, Galuska MA, Hamilton RJ. Beta-Blocker Toxicity. In: StatPearls. StatPearls Publishing. NIH: National Library of Medicine – National Center for Biotechnology Information. Published July 28, 2023. https://www.ncbi.nlm.nih.gov/books/NBK448097/ Srettabunjong S. Fatal Self-Poisoning With Massive Propranolol Ingestion in a Young Male Physician. Am J Forensic Med Pathol. PubMed®. NIH: National Library of Medicine – National Center for Biotechnology Information. Published September 2017. https://pubmed.ncbi.nlm.nih.gov/28691951/ Segment 3 – Snake bites Rohl S, Meredith M, Anderson, T, et al. Comparing the Use of Crotaline-Polyvalent Immune Fab (Ovine) Versus Observation in Children. Pediatric Emergency Care: Dedicated to the Care of the Ill or Injured Child. Lww.com. Published November 2024. https://journals.lww.com/pec-online/abstract/2024/11000/comparingtheuseofcrotalinepolyvalentimmune.19.aspx Snake bites. Wikem.org. WikiEM. Last edited March 17, 2021. https://wikem.org/wiki/Snake_bites Toxicology resources Goldfrank LR, Flomenbaum NE, Howland MA, et al. Goldfrank's Toxicologic Emergencies. 8th ed. McGraw-Hill Medical; 2006. Katz K, O'Connor A, Amaducci AM. EMRA and ACMT Medical Toxicology Guide: 2nd Edition.; 2022. National Poison Data System. Poisoncenters.org. America's Poison Centers: Treatment, Education, Prevention. Accessed April 9, 2025. https://poisoncenters.org/national-poison-data-system Poison Control: National Capital Poison Center. Poison.org. Accessed April 9, 2025. https://www.poison.org/ Segment 4 – Special guest: Nancy Denke, DNP, ACNP-BC, FNP-BC, FAEN, CEN, CCRN, of Arizona Linkedin.com. Accessed April 9, 2025. https://www.linkedin.com/in/nancy-denke-dnp-acnp-bc-fnp-bc-faen-a62851 Nancy Denke, DNP, ACNP-BC, FNP-BC, FAEN, CEN, CCRN, of Arizona. ENA Hall of Honor. Published July 26, 2024. Accessed April 9, 2025. https://hall-of-honor.org/nancy-denke PodBean Development. Talking Toxicology: A Recipe for Disaster (Nancy Denke). BCEN & Friends Podcast. PodBean. Published March 7, 2023. https://bcenandfriends.podbean.com/e/talking-toxicology-a-recipe-for-disaster-nancy-denke/ *Recurring Sources * Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

CME professionals, medical writers, educators, and researchers - what would you do if PubMed suddenly became less accessible? You depend on this critical resource daily to find evidence-based information that powers your work. But recent funding uncertainties at the NIH have raised questions about its future. You need consistent, reliable access to quality biomedical research to meet deadlines and maintain credibility, but navigating alternatives can feel overwhelming. Where would you even begin if your go-to resource is compromised? Today's episode is your insurance policy. My conversation with medical librarian Rachel Wedeward MLIS, AHIP reveals not only why PubMed matters, but also provides you with practical alternatives, including a downloadable resource sheet, and evaluation strategies to ensure you'll never be left without the research you need - no matter what happens. In this episode, you'll discover: The remarkable infrastructure behind PubMed's indexing system that makes it an indispensable tool for organizing and accessing biomedical research A comprehensive overview of complementary resources, including European PubMed Central and specialized databases that can enhance your research approach Practical wisdom for evaluating evidence quality Listen now to expand your research toolkit with expert knowledge that will help you confidently navigate the evolving landscape of medical information resources. Connect with Rachel Website LinkedIn

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Joe Cohen's journey to optimal health is a story of self-discovery and a drive to find answers beyond conventional medicine. Struggling with chronic health issues like fatigue, inflammation, and brain fog, Joe took charge of his health by diving into genetics, biomarkers, and biohacking. A Start of Struggle: The Search for Answers Joe's early attempts to seek help from mainstream doctors were unfruitful. Frustrated, he embarked on self-experimentation. He started with lifestyle changes like intermittent fasting and cold plunges, which offered some relief. However, it was when Joe incorporated supplements into his regimen that he began to experience more significant improvements. The Quest for Scientific Answers Determined to understand his body, Joe turned to scientific resources like PubMed and Wikipedia. He discovered that health protocols were not one-size-fits-all. Joe tried various diets, such as veganism and the Bulletproof Diet, but ultimately found success with a carnivore and lectin-free approach. He realized that his body didn't respond well to grains and legumes, leading him to adopt a lectin-avoidance diet early on. The Power of Genetics and Personalized Experimentation Joe realized that understanding his individual biology was key. He learned that genetic factors, such as immune system dominance, played a crucial role in how his body reacted to different foods and supplements. This led to the development of SelfDecode, a platform providing genetic insights for personalized health optimization. He found that genetic testing, combined with lab testing and supplements, offered a holistic approach. Supplementation: The Game Changer For Joe, supplementation became a cornerstone of his biohacking strategy. He believes supplements have had the most significant impact on his health. With over 160 supplements in his daily regimen, Joe emphasizes the importance of understanding which supplements are best for an individual's unique needs. He encourages guided experimentation to find the right mix, considering genetics, biomarkers, and personal health goals. The Future of Biohacking: AI, Genetics, and Longevity Joe envisions a future where breakthroughs in organ replacement and genetic manipulation could significantly extend human lifespan. He also sees AI playing a crucial role in improving genetic research, health recommendations, and biohacking strategies. The Key to Rewiring Your Health Joe Cohen's journey shows that optimizing your health requires scientific inquiry, personalized experimentation, and an open mind toward biohacking tools. By understanding your body deeply and embracing self-experimentation, you can create a health protocol tailored to your unique needs. In this podcast, you'll learn: How Joe took control of his health when conventional medicine failed him. The power of personalized supplements and why they are crucial for optimal health. Why understanding your unique biology and genetics is essential for health optimization. How Joe developed a lectin-free diet before it became mainstream and why it worked for him. Joe's vision for the future of biohacking, including AI and genetic manipulation for longevity.   EPISODE RESOURCES: Website Instagram Youtube  

In this second episode of a three-part series, Drs. Ruth Carrico and Paula Tucker explore the challenges of medical misinformation, its impact on patient care and strategies for navigating the overwhelming flow of health information in today's digital age. The discussion covers the rise of the "infodemic” how misinformation spreads and how nurse practitioners (NPs) can critically evaluate medical literature to ensure evidence-based practice. The hosts share real-world experiences from the COVID-19 pandemic, highlighting the difficulties of adapting to rapidly evolving guidelines while maintaining public trust. They also discuss the role of social determinants of health in the spread of misinformation and provide practical solutions for mitigating misinformation in clinical settings. Key Takeaways: Understanding the Infodemic: Definition: An overload of health-related information — both accurate and inaccurate — spread rapidly via social media, news and professional circles. Impact of COVID-19: Misinformation amplified due to evolving scientific knowledge, political influences and social media algorithms. Role of Trust: Public mistrust in health care institutions and shifting guidelines fueled skepticism. Misinformation Drivers and Consequences: Psychological Factors: Cognitive biases (confirmation bias, authority bias) make individuals more susceptible to misinformation. Technology and Social Media: Algorithm-driven content creates echo chambers where misinformation spreads unchecked. Public Health Outcomes: Misinformation leads to vaccine hesitancy, delayed treatments and preventable deaths. How NPs Can Combat Misinformation: 1. Active Listening: Understand patients' concerns before correcting misinformation. 2. Effective Communication: Use simple, culturally relevant messaging tailored to health literacy levels. 3. Building Resilience: Teach patients how to critically evaluate health information sources. 4. Community Engagement: Collaborate with local leaders and organizations to promote credible information. Evaluating Evidence-Based Information: Use the CRAAP Test (Currency, Relevance, Authority, Accuracy, Purpose) to assess credibility. Trust peer-reviewed sources like CDC, WHO, FDA, Cochrane Reviews and PubMed. Be aware of misleading studies and cherry-picked data used to spread misinformation. Trusted Resources for Patients and Providers: For Clinicians: UpToDate, DynaMed, BMJ Best Practice, Cochrane Reviews. For Patients: MedlinePlus, Mayo Clinic, CDC Vaccine Fact Sheets, American Heart Association. To claim 1.1 contact hours (CH) of continuing education (CE) credit for this program, “Navigating the Infodemic: A Call for Critical Thinking to Optimize Patient Care,” search for this program by the title and complete the posttest and evaluation by entering the participation code provided after listening to the podcast. “This activity is sponsored by an independent medical education grant from Kenvue.” Tool: https://www.aanp.org/practice/clinical-resources-for-nps/clinical-resources-by-therapeutic-area/primary-care Next Episode Preview: In the final episode of this series, Drs. Carrico and Tucker will dive into practical strategies for debunking medical myths, patient-centered communication techniques and choosing the right battles when addressing misinformation.

On the inaugural episode of ASCO Education: By the Book, Dr. Nathan Pennell and Dr. Don Dizon share reflections on the evolution of the ASCO Educational Book, its global reach, and the role of its new companion podcast to further shine a spotlight on the issues shaping the future of modern oncology. TRANSCRIPT Dr. Nathan Pennell: Hello, I'm Dr. Nate Pennell, welcoming you to the first episode of our new podcast, ASCO Education: By the Book. The podcast will feature engaging discussions between editors and authors from the ASCO Educational Book. Each month, you'll hear nuanced views on key topics in oncology featured in Education Sessions at ASCO meetings, as well as some deep dives on the advances shaping modern oncology. Although I am honored to serve as the editor-in-chief (EIC) of the ASCO Educational Book, in my day job, I am the co-director of the Cleveland Clinic Lung Cancer Program and vice chair for clinical research for the Taussig Cancer Center here in Cleveland. I'm delighted to kick off our new podcast with a discussion featuring the Ed Book's previous editor-in-chief. Dr. Don Dizon is a professor of medicine and surgery at Brown University and works as a medical oncologist specializing in breast and pelvic malignancies at Lifespan Cancer Institute in Rhode Island. Dr. Dizon also serves as the vice chair for membership and accrual at the SWOG Cancer Research Network. Don, it's great to have you here for our first episode of ASCO Education: By the Book. Dr. Don Dizon: Really nice to be here and to see you again, my friend. Dr. Nathan Pennell: This was the first thing I thought of when we were kicking off a podcast that I thought we would set the stage for our hopefully many, many listeners to learn a little bit about what the Ed Book used to be like, how it has evolved over the last 14 years or so since we both started here and where it's going. You started as editor-in-chief in 2012, is that right? Dr. Don Dizon: Oh, boy. I believe that is correct, yes. I did two 5-year stints as EIC of the Educational Book, so that sounds about right. Although you're aging me very clearly on this podcast. Dr. Nathan Pennell: I had to go back in my emails to see if I could figure out when we started on this because we've been working on it for some time. Start out a little bit by telling me what do you remember about the Ed Book from back in the day when you were applying to be editor-in-chief and thinking about the Ed Book. What was it like at that time? Dr. Don Dizon: You know, it's so interesting to think about it.  Ten years ago, we were both in a very different place in our careers, and I remember when the Ed Book position came up, I had been writing a column for ASCO. I had done some editorial activities with other journals for sure, but what always struck me was it was very unclear how one was chosen to be a part of the education program at ASCO. And then it was very unclear how those faculty were then selected to write a paper for the Educational Book. And it was back in the day when the Educational Book was completely printed. So, there was this book that was cherished among American fellows in oncology. And it was one that, when I was newly attending, and certainly two or three years before the editor's position came up, it was one that I referenced all the time. So, it was a known commodity for many of us. And there was a certain sense of selectivity about who was invited to write in it. And it wasn't terribly transparent either. So, when the opportunity to apply for editor-in-chief of the Educational Book came up, I had already been doing so much work for ASCO. I had been on the planning committees and served in many roles across the organization, and editing was something I found I enjoyed in other work. So, I decided to put my name in the ring with the intention of sort of bringing the book forward, getting it indexed, for example, so that there was this credit that was more than just societal credit at ASCO. This ended up being something that was referenced and acknowledged as an important paper through PubMed indexing. And then also to provide it as a space where we could be more transparent about who was being invited and broadening the tent as to who could participate as an author in the Ed Book. Dr. Nathan Pennell: It's going to be surprising to many of our younger listeners to learn that the Educational Book used to be just this giant, almost like a brick. I mean, it was this huge tome of articles from the Education Sessions that you got when you got your meeting abstracts book at the annual meeting. And you can always see people on the plane on the way out of Chicago with their giant books. Dr. Don Dizon: Yes. Dr. Nathan Pennell: That added lots of additional weight to the plane, I'm sure, on the way out. Dr. Don Dizon: And it was not uncommon for us to be sitting at an airport, and people would be reading those books with highlighters. Dr. Nathan Pennell: I fondly remember being a fellow and coming up and the Ed Book was always really important to me, so I was excited. We'll also let the listeners in on that. I also applied to be the original editor-in-chief of the Ed Book back in 2012, although I was very junior and did not have any real editorial experience. I think I may have been section editor for The Oncologist at that point. And I had spoken to Dr. Ramaswamy Govindan at WashU who had been the previous editor-in-chief about applying and he was like, “Oh yeah. You should absolutely try that out.” And then when Dr. Dizon was chosen, I was like, “Oh, well. I guess I didn't get it.” And then out of the blue I got a call asking me to join as the associate editor, which I was really always very thankful for that opportunity. Dr. Don Dizon: Well, it was a highly fruitful collaboration, I think, between you and I when we first started. I do remember taking on the reins and sort of saying, “You know, this is our vision of what we want to do.” But then just working with the authors, which we did, about how to construct their papers and what we were looking for, all of that is something I look back really fondly on. Dr. Nathan Pennell: I think it was interesting too because neither one of us had really a lot of transparency into how things worked when we started. We kind of made it up a little bit as we went along. We wanted to get all of the faculty, or at least as many of them as possible contributing to these. And we would go to the ASCO Education Committee meeting and kind of talk about the Ed Book, and we were thinking about, you know, how could we get people to submit. So, at the time it wasn't PubMed indexed. Most people, I think, submitted individual manuscripts just from their talk, which could be anywhere from full length review articles to very brief manuscripts. Dr. Don Dizon: Sometimes it was their slides with like a couple of comments on it. Dr. Nathan Pennell: And some of them were almost like a summary of the talk. Yeah, exactly. And so sort of making that a little more uniform. There was originally an honorarium attached, which went away, but I think PubMed indexing was probably the biggest incentive for people to join. I remember that was one of the first things you really wanted to get. Dr. Don Dizon Yeah. And, you know, it was fortuitous. I'd like to take all the credit for it, but ASCO was very forward thinking with Dr. Ramaswamy and the conversations about going to PubMed with this had preceded my coming in. We knew what we needed to do to get this acknowledged, which was really strengthening the peer review so that these papers could meet the bar to get on PubMed. But you know, within the first, what, two or three years, Nate, of us doing this, we were able to get this accepted. And now it is. If you look at what PubMed did for us, it not only increased the potential of who was going to access it, but for, I think the oncology community, it allowed people access to papers by key opinion leaders that was not blocked by a paywall. And I thought that was just super important at the time. Social media was something, but it wasn't what it is now. But anybody could access these manuscripts and it's still the case today. Dr. Nathan Pennell: I think it's hard to overstate how important that was. People don't realize this, but the Ed Book is really widely accessed, especially outside the US as well. And a lot of people who can't attend the meeting to get the print, well, the once print, book could actually get access to essentially the education session from the annual meeting without having to fly all the way to the US to attend. Now, you know, we have much better virtual meeting offerings now and whatnot. But at the time it was pretty revolutionary to be able to do that. Dr. Don Dizon: Yeah, and you know, it's so interesting when I think back to, you know, this sort of evolution to a fully online publication of the Ed Book. It was really some requests from international participants of the annual meeting who really wanted to continue to see this in print. At that time, it was important to recognize that access to information was not uniform across the world. And people really wanted that print edition, maybe not for themselves, but so that access in more rural areas or where access in the broadband networks were not established that they still could access the book. I think things have changed now. We were able, I think, in your tenure, to see it fully go online. But even I just remember that being a concern as we went forward. Dr. Nathan Pennell: Yeah, we continued with the print book that was available if people asked for it, but apparently few enough people asked for it that it moved fully online. One of the major advantages of being fully online now is of course, it does allow us to publish kind of in real time as the manuscripts come out in the months leading up to the meeting, which has been, I think, a huge boon because it can build momentum for the Education Sessions coming in. People, you know, really look forward to it. Dr. Don Dizon: Yeah, that was actually a concern, you know, when we were phasing out Ed Book and going to this continuous publication model where authors actually had the ability to sort of revise their manuscript and that would be automatically uploaded. You had a static manuscript that was fully printed, and it was no longer an accurate one. And we did have the ability to fix it. And it just goes to show exactly what you're saying. This idea that these are living papers was really an important thing that ASCO embraced quite early, I think. Dr. Nathan Pennell: And with the onset of PubMed indexing, the participation from faculty skyrocketed and almost within a couple of years was up to the vast majority of sessions and faculty participating. Now I think people really understand that this is part of the whole process. But at the time I remember writing out on my slides in all caps, “THIS IS AN EXPECTATION.” And that's about the best word I could give because I asked if we could make people do it, and they were like, no, you can't make people do it. Dr. Don Dizon: So right.  Actually, I don't think people are aware of the work on the back end every year when I was on as EIC, Nate and myself, and then subsequently Dr. Hope Rugo would have these informational sessions with the education faculty and we would tout the Ed Book, tout the expectation, tout it was PubMed indexed and tout multidisciplinary participation. So, we were not seeing four manuscripts reflecting one session. You know, this encouragement to really embrace multidisciplinary care was something that very early on we introduced and really encouraged people not to submit perspective manuscripts, but to really get them in and then harmonize the paper so that it felt like it was, you know, one voice. Dr. Nathan Pennell: I consider that after PubMed indexing, the next major change to the Ed Book, that really made it a better product and that was moving from, you know, just these short individual single author manuscripts to single session combined manuscript that had multiple perspectives and topics, really much more comprehensive review articles. And I don't even remember what the impetus was for that, but it was really a success. Dr. Don Dizon: Yeah, I mean, I think in the beginning it was more of a challenge, I think, because people were really not given guidance on what these papers were supposed to look like. So, we were seeing individual manuscripts come forward. Looking back, it really foreshadowed the importance of multidisciplinary management. But at the time, it was really more about ensuring that people were leaving the session with a singular message of what to do when you're in clinic again. And the goal was to have the manuscripts reflect that sort of consensus view of a topic that was coming in. There were certain things that people still argued would not fit in a multidisciplinary manuscript. You know, if you have someone who's writing and whose entire talk was on the pathology of thyroid cancer. Another topic was on survivorship after thyroid cancer. It was hard to sort of get those two to interact and cover what was being covered. So, we were still getting that. But you're right, at the end of my tenure and into yours, there were far fewer of those individual manuscripts. Dr. Nathan Pennell: And I think it's even made it easier to write because now, you know, you just have to write a section of a manuscript and not put together an entire review. So, it has helped with getting people on board. Dr. Don Dizon: Well, the other thing I thought was really interesting about the process is when you're invited to do an Education Session at ASCO, you're either invited as a faculty speaker or as the chair of the session. And the responsibility of the chair is to ensure that it flows well and that the talks are succinct based on what the agenda or the objectives were as defined by the education committee for that specific group. But that was it. So really being named “Chair” was sort of an honor, an honorific. It really didn't come with responsibility. So, we use the Ed Book as a way to say, “As chair of the session, it is your responsibility to ensure A, a manuscript comes to me, but B, that the content of that paper harmonizes and is accurate.” And it was very rare, but Nate, I think we got dragged into a couple of times where the accuracy of the manuscript was really called into question by the chair. And those were always very, very tricky discussions because everyone that gets invited to ASCO is a recognized leader in their field. Some of us, especially, I would probably say, dating back 10 years from today, the data behind Standards of Care were not necessarily evidence-based. So, there were a lot of opinion-based therapies. You know, maybe not so much in the medical side, but certainly some of it. But when you went to, you know, surgical treatments and maybe even radiotherapy treatments, it was really based on, “My experience at my center is this and this is why I do what I do.” But those kinds of things ended up being some of the more challenging things to handle as an editor. Dr. Nathan Pennell: And those are the– I'll use “fun” in a broad sense. You know, every once in a while, you get an article where it really does take a lot of hands-on work from the editor to work with the author to try to revise it and make it a suitable academic manuscript. But you know what? I can't think, at least in recent years, of any manuscripts that we turned down. They just sometimes needed a little TLC. Dr. Don Dizon: Yeah. And I think the other important thing it reminds me of is how great it was that I wasn't doing this by myself. Because it was so great to be able to reach out to you and say, “Can you give me your take on this paper?” Or, “Can you help me just join a conference call with the authors to make sure that we're on the same page?” And then on the rare example where we were going to reject a paper, it was really important that we, as the editorial team, and I include our ASCO shepherder, through the whole process. We had to all agree that this was not salvageable. Fortunately, it happened very rarely. But I've got to say, not doing this job alone was one of the more important facets of being the EIC of ASCO's Educational Book. Dr. Nathan Pennell: Well, it's nice to hear you say that. I definitely felt that this was a partnership, you know, it was a labor of love. So, I want to go to what I consider sort of the third major pillar of the changes to the Ed Book during your tenure, and that was the introduction of a whole new kind of manuscript. So up to, I don't know, maybe seven or eight years ago, all the articles were authored just by people who were presenting at the Annual Meeting. And then you had an idea to introduce invited manuscripts. So take me through that. Dr. Don Dizon: Yeah, well, you know, again, it went to this sort of, what can people who are being asked to sort of lead ASCO for that year, what can they demonstrate as sort of a more tangible contribution to the Society and to oncology in general? And I think that was the impetus to use the Ed Book for everyone who was in a leadership position to make their mark. That said, I was here, and I was either president of the society or I was Education Program Chair or Scientific Program Chair, and they got to select an article type that was not being covered in the annual meeting and suggest the authors and work with those authors to construct a manuscript. Never did any one of those folks suggest themselves, which I thought was fascinating. They didn't say, “I want to be the one to write this piece,” because this was never meant to be a presidential speech or a commemorative speech or opportunity for them as leaders. But we wanted to ensure that whatever passion they had within oncology was represented in the book. And again, it was this sort of sense of, I want everyone to look at the Ed Book and see themselves in it and see what they contributed. And that was really important for those who were really shepherding each Annual Meeting each year for ASCO that they had the opportunity to do that. And I was really pleased that leadership really took to that idea and were very excited about bringing ideas and also author groups into the Educational Book who would not have had the opportunity otherwise. I thought that was just really nice. It was about inclusiveness and just making sure that people had the opportunity to say, “If you want to participate, we want you to participate.” Dr. Nathan Pennell: Yeah, I agree. I think the ASCO leadership jumped on this and continues to still really appreciate the opportunity to be able to kind of invite someone on a topic that's meaningful to them. I think we've tried to work in things that incorporate the presidential theme each year in our invited manuscript, so it really allows them to put kind of a stamp on the flavor of each edition. And the numbers reflect that these tend to be among our more highly read articles as well. Dr. Don Dizon: You know, looking back on what we did together, that was something I'm really, really quite proud of, that we were able to sort of help the Educational Book evolve that way. Dr. Nathan Pennell: I agree. You brought up briefly a few minutes ago about social media and its role over time. I think when we started in 2012, I had just joined Twitter now X in 2011, and I think we were both sort of early adopters in the social media. Do you feel like social media has had a role in the growth of the Ed Book or is this something that you think we can develop further? Dr. Don Dizon: When we were doing Ed Book together, professional social media was actually a quite identified space. You know, we were all on the same platform. We analyzed what the outcomes were on that platform and our communities gathered on that platform. So, it was a really good place to highlight what we were publishing, especially as we went to continuous publishing.  I don't remember if it was you or me, but we even started asking our authors for a tweet and those tweets needed work. It was you. It was you or I would actually lay in these tweets to say, “Yeah, we need to just, you know, work on this.” But I think it's harder today. There's no one preferred platform. Alternate platforms are still evolving. So, I think there are opportunities there. The question is: Is that opportunity meaningful enough for the Ed Book to demonstrate its return on an investment, for example? What I always thought about social media, and it's still true today, is that it will get eyes on whatever you're looking at far beyond who you intended to see it. So, you know, your tweets regarding a phase 3 clinical trial in lung cancer, which were so informative, were reaching me, who was not a lung oncologist who doesn't even see lung cancer and getting me more interested in finding that article and more and more pointing to the Educational Book content that speaks to that piece, you know. And I think coupling an impression of the data, associating that with something that is freely accessed is, I think, a golden opportunity not only for our colleagues, but also for anyone who's interested in a topic. Whether you are diagnosed with that cancer or you are taking care of someone with that cancer, or you heard about that cancer, there are people who would like to see information that is relevant and embedded and delivered by people who know what they're talking about. And I think our voices on social media are important because of it. And I think that's where the contribution is. So, if we had to see what the metric was for any social media efforts, it has to be more of the click rates, not just by ASCO members, but the click rates across societies and across countries. Dr. Nathan Pennell: Yeah, social media is, I mean, obviously evolving quite a bit in the last couple of years. But I do know that in terms the alt metrics for the track access through social media and online, the ones that are shared online by the authors, by the Ed Book team, do seem to get more attention. I think a lot of people don't like to just sit with a print journal anymore or an email table of contents for specific journals. People find these articles that are meaningful to them through their network and oftentimes that is online on social media. Dr. Don Dizon: Yes, 100%. And you know what I think we should encourage people to do is look at the source. And if the Ed Book becomes a source of information, I think that will be a plus to the conversations in our world. We're still dealing with a place where, depending on who sponsored the trial, whether it was an industry-sponsored trial, whether it was NCI sponsored or sponsored by the National Institutes of Health, for example, access to the primary data sets may or may not be available across the world, but the Ed Book is. And if the Ed Book can summarize that data and use terms and words that are accessible no matter what your grade level of education is. If we can explain the graphs and the figures in a way that people can actually easily more understand it. If there's a way that we structure our conversations in the Ed Book so that the plethora of inclusion/exclusion criteria are summarized and simplified, then I think we can achieve a place where good information becomes more accessible, and we can point to a summary of the source data in places where the source is not available. Dr. Nathan Pennell: One of the other things that I continue to be surprised at how popular these podcasts are. And that gives you an opportunity pretty much the opposite. Instead of sort of a nugget that directs you to the source material, you've got a more in-depth discussion of the manuscript. And so, I'm delighted that we have our own podcast. For many years, the Ed Book would sort of do a sort of a “Weird Al takeover” of the ASCO Daily News Podcast for a couple of episodes around the Annual Meeting, and I think those were always really popular enough that we were able to argue that we deserved our own podcast. And I'm really looking forward to having these in-depth discussions with authors. Dr. Don Dizon: It's an amazing evolution of where the Ed Book has gone, right? We took it from print only, societally only, to something that is now accessed worldwide via PubMed. We took it from book to fully online print. And now I think making the content live is a natural next step. So, I applaud you for doing the podcast and giving people an opportunity actually to discuss what their article discusses. And if there's a controversial point, giving them the freedom and the opportunity to sort of give more nuanced views on what may not be something that there's 100% consensus over. Dr. Nathan Pennell: Yes. Well, I hope other people enjoy these as well. Just want to highlight a few of the things that have happened just in the couple years since you stepped down as editor-in-chief. One of them, and I don't know if you noticed, but last year we started adding manuscripts from the ASCO thematic meetings, so ASCO GI and ASCO GU, something we had certainly talked about in the past, but had lacked bandwidth to really do. And they seem to be pretty widely accessed. Dr. Don Dizon: That's fantastic. Yes, I do remember talking about the coverage of the thematic meetings and you're right, this takes a long time to sort of concentrate on the Annual Meeting. It may seem like everything happens in the span of like eight weeks. Dr. Nathan Pennell: It does feel like that sometimes. Dr. Don Dizon: Right? But this is actually something that starts a year before, once the education program is set. We're in the room when they set it. But then it's really chasing down manuscripts and then making sure that they're peer reviewed because the peer review is still really important, and then making sure that any revisions are made before it's finalized and goes to press. That is a many months process. So, when we're trying to introduce, “Oh, we should also do ASCO GU or-,” the question was, how do you want to do that given this very, very involved process going forward? So, I'm glad you were able to figure it out. Dr. Nathan Pennell: Well, it's challenging. I don't think people realize quite the compressed timeline for these. You know, the Education Session and authors and invited faculty are picked in the fall, and then basically you have to start turning in your manuscripts in February, March of the following year. And so, it's a really tight turnaround for this. When we talk about the ASCO thematic meetings, it's an even tighter window. Dr. Don Dizon: Right, exactly. Dr. Nathan Pennell: And so, it's challenging to get that moving, but I was really, really proud that we were able to pull that off. Dr. Don Dizon: Well, congratulations again. And I think that is a necessary step, because so much of what's going on in the various disease management sites is only covered cursorily through the Annual Meeting itself. I mean, there's just so much science breaking at any one time that I think if we want to comprehensively catalog the Year in Review in oncology, it kind of behooves us to do that. Dr. Nathan Pennell: Some other things that are coming up because we now have manuscripts that are going to be coming in year-round, and just to kind of make it easier on the editorial staff, we're going to be forming an editorial board. And in addition to our pool of reviewers who get ASCO points, please feel free to go online to the ASCO volunteer portal and sign up if you are interested in participating. So, moving forward, I'm really excited to see where things are going to go. Dr. Don Dizon: Well, that's great. That's great. And I do remember talking about whether or not we needed to have an editorial board. At least when I was there, having this carried by three people was always better than having it carried by one person. And I think as you expand the potential for submissions, it will be very helpful to have that input for sure. And then it gives another opportunity for more members to get involved in ASCO as well. Dr. Nathan Pennell: Absolutely. People want involvement, and so happy to provide that. Dr. Don Dizon: Yes. Dr. Nathan Pennell: Is there anything we didn't cover that you would like to mention before we wrap up? Dr. Don Dizon: Well, I will say this, that ASCO and through its publications not only has had this real emphasis on multidisciplinary management of cancers, especially where it was relevant, but it also always had a stand to ensure representation was front and center and who wrote for us. And I think every president, every chair that I've worked with naturally embraced that idea of representation. And I think it has been a distinct honor to say that during my tenure as EIC, we have always had a plethora of voices, of authors from different countries, of genders, that have participated in the construction of those books. And it stands as a testament that we are a global community and we will always be one. Dr. Nathan Pennell: Well, thank you for that. And I'm happy to continue that as we move forward. Well, Don, thank you. It's been great speaking with you. You played such a pivotal role in the Ed Book's evolution and I'm so glad you were able to join me for our inaugural episode. Dr. Don Dizon: Well, I'm just tickled that you asked me to be your first guest. Thank you so much, Nate. Dr. Nathan Pennell: And I also want to thank our listeners for joining us today. We hope you'll join us again for more insightful views on topics you'll be hearing at the Education Sessions from ASCO meetings throughout the year, as well as our periodic deep dives on advances that are shaping modern oncology. Have a great day. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Follow today's speakers:   Dr. Nathan Pennell  @n8pennell @n8pennell.bsky.social   Dr. Don Dizon @drdondizon.bsky.social  Follow ASCO on social media:   @ASCO on X (formerly Twitter)   ASCO on Bluesky  ASCO on Facebook   ASCO on LinkedIn   Disclosures:  Dr. Nathan Pennell:      Consulting or Advisory Role: AstraZeneca, Lilly, Cota Healthcare, Merck, Bristol-Myers Squibb, Genentech, Amgen, G1 Therapeutics, Pfizer, Boehringer Ingelheim, Viosera, Xencor, Mirati Therapeutics, Janssen Oncology, Sanofi/Regeneron     Research Funding (Inst): Genentech, AstraZeneca, Merck, Loxo, Altor BioScience, Spectrum Pharmaceuticals, Bristol-Myers Squibb, Jounce Therapeutics, Mirati Therapeutics, Heat Biologics, WindMIL, Sanofi  Dr. Don Dizon: Stock and Other Ownership Interests: Midi, Doximity Honoraria: UpToDate, American Cancer Society Consulting or Advisory Role: AstraZeneca, Clovis Oncology, Kronos Bio, Immunogen Research Funding (Institution): Bristol-Myers Squibb          

Wednesday, April 9, 2025 – Week 15   Condolences to the Brimsek family and thank you John & Tobi for all your support.  We just shared an interview with our board member and John's son-in-law, Eric Moulton https://cureSYNGAP1.org/Stories    Trip Report, two crazy days.  Many takeaways.  Trials may be coming soon.  If there is a trail, sign up.  Every time. khuba@jcu.edu    Do the Frazier Study and do the follow-ups!  https://curesyngap1.org/eye2 Global as well.  Australia, UK, Canada, please help.   We are busy too!  DiMe announcement just came out https://www.linkedin.com/posts/curesyngap1_new-project-announcement-children-with-activity-7315615778366537728-c-gU    Census is 1,581!  https://curesyngap1.org/blog/syngap1-census-2025-update-q1/   Impact report has a webinar! https://cureSYNGAP1.org/Impact    Both featured in Newsletter #44 - https://cureSYNGAP1.org/NL44   Monday 4/14 we have a webinar - Natural History & Clinical Trial Readiness - with Dr. McKee https://cureSYNGAP1.org/Jill    We have one space available in Colorado on May 20, 2025, email Lauren@curesyngap1.org to sign up.   Other blog about the CB Roadshow, please join us there https://curesyngap1.org/blog/fueling-research-syngap1-combinedbrain-biorepository-roadshow/   And the Polish Community speaking out about ASO trials: https://curesyngap1.org/blog/aso-choice-for-hope-syngap1-voices-from-poland/   #Sprint4Syngap 2025 is in one month! Start or join a team and fundraise! https://curesyngap1.org/sprint25 look at these faces, $66,383 https://www.youtube.com/watch?v=IW7owIsdjss   Bowie - Our funding goes far: https://www.eurekalert.org/news-releases/1078836 remember in July 2022 https://www.eurekalert.org/news-releases/960181    Also see this from CZI, featuring SYNGAP1 in Dr. Willsey's work https://www.czbiohub.org/life-science/unlocking-biology-autism/   PubMed is at 17 YTD, 324 in total (trending to 52+, but I'm not as confident) https://pubmed.ncbi.nlm.nih.gov/?term=syngap1&filter=years.1998-2025&timeline=expanded&sort=date&sort_order=asc   VOLUNTEER  Join us: https://curesyngap1.org/volunteer-with-srf/   SOCIAL MATTERS - 3,996 LinkedIn.  https://www.linkedin.com/company/curesyngap1/ - 1,334 YouTube.  https://www.youtube.com/@CureSYNGAP1  - 11,391 Twitter https://twitter.com/cureSYNGAP1 - 46k Insta https://www.instagram.com/curesyngap1/    NEWLY DIAGNOSED? New families have resources here! https://syngap.fund/Resources    Podcasts, give all of these a five star review! https://podcasts.apple.com/us/channel/syngap1-podcasts-by-srf/id6464522917   Episode 168 of #Syngap10  #Advocate #PatientAdvocacy #UnmetNeed #SYNGAP1 #SynGAP #SynGAProMMiS

Welcome to the SYNC Your Life podcast episode #317! On this podcast, we will be diving into all things women's hormones to help you learn how to live in alignment with your female physiology. Too many women are living with their check engine lights flashing. You know you feel “off” but no matter what you do, you can't seem to have the energy, or lose the weight, or feel your best. This podcast exists to shed light on the important topic of healthy hormones and cycle syncing, to help you gain maximum energy in your life.  In today's episode, I dive into whether or not there is a "faster way" to losing weight. I dive into common questions I get regarding carb cycling, fasting, and more, and whether those things are good for female physiology.  I reference Dr. Stacy Sims and her research on this in multiple instances. You can learn more via Sims' blog found here. Dr. Sims also has several articles published via PubMed on the subject of female athletes. If you're a woman who trains, you're an athlete, so this research is most relevant! I've linked only a few research articles here: Low Energy Availability in Women Female Specific Nutrition Nutritional Concerns for Female Athletes To learn more about the SYNC™ course and fitness program, click here. To learn more about virtual consults with our resident hormone health doctor, click here. If you feel like something is “off” with your hormones, check out the FREE hormone imbalance quiz at sync.jennyswisher.com.  To learn more about Hugh & Grace and my favorite 3rd party tested endocrine disruption free products, including skin care, home care, and detox support, click here. To learn more about the SYNC and Hugh & Grace dual income opportunity, click here. Let's be friends outside of the podcast! Send me a message or schedule a call so I can get to know you better. You can reach out at https://jennyswisher.com/contact-2/. Enjoy the show! Episode Webpage: jennyswisher.com/podcast

Welcome to Episode 44 of “The 2 View,” the podcast for EM and urgent care nurse practitioners and physician assistants! Show Notes for Episode 44 of “The 2 View” – The Pitt, Cardiac Arrest in Young People, and Influenza Associated Encephalopathy. Segment 1 – Fraud and Conspiracy and Schemes, Oh My! Florida Physician Assistant Pleads Guilty to a $7.3 Million Health Care Fraud Conspiracy. United States Attorney's Office: District of New Hampshire. United States Department of Justice. Justice.gov. December 3, 2024. https://www.justice.gov/usao-nh/pr/florida-physician-assistant-pleads-guilty-73-million-health-care-fraud-conspiracy Nurse Practitioner Sentenced To Five Years In Prison For $11.2 Million Disability Loan Fraud Scheme. United States Attorney's Office: Sothern District of New York. United States Department of Justice. Justice.gov. February 5, 2025. https://www.justice.gov/usao-sdny/pr/nurse-practitioner-sentenced-five-years-prison-112-million-disability-loan-fraud The Board of Certification for Emergency Nursing. BCEN. February 17, 2023. http://www.bcen.org Segment 2 – Prehospital Tourniquet Application Rittblat M, Gendler S, Tsur N, Radomislensky I, Ziv A, Bodas M. The cost of saving lives: Complications arising from prehospital tourniquet application. WILEY Online Library. Acad Emerg Med. December 16, 2024. https://onlinelibrary.wiley.com/doi/10.1111/acem.15070 The Center for Medical Education. 2 View: Emergency medicine PAs & NPs: 41 - RCVS and CVT, CPR Care Science, Prehospital Tourniquets, Blood Pressure. 2 View: Emergency Medicine PAs & NPs. January 22, 2025. https://2view.fireside.fm/41 Segment 3 – Cardiac Arrest in Young People Chia MYC, Lu QS, Rahman NH, et al. Characteristics and outcomes of young adults who suffered an out-of-hospital cardiac arrest (OHCA). NIH: National Library of Medicine – National Center for Biotechnology Information. PubMed. Resuscitation. February 2017. https://pubmed.ncbi.nlm.nih.gov/27923113/ Parekh S. Teen athlete saved after cardiac arrest speaks out: What to know about lifesaving role of CPR, AEDs in schools. GMA. ABC News. September 6, 2024. https://www.goodmorningamerica.com/wellness/story/teen-athlete-saved-after-cardiac-arrest-speaks-lifesaving-113460919 The Center for Medical Education. 2 View: Emergency medicine PAs & NPs: 42 - Pink Cocaine, Holiday Heart Syndrome, Pertussis, Research Updates, and More! 2 View: Emergency Medicine PAs & NPs. February 12, 2025. https://2view.fireside.fm/42 Tseng Z, Nakasuka K. Out-of-Hospital Cardiac Arrest in Apparently Healthy, Young Adults. JAMA Network. Jamanetwork.com. February 20, 2025. https://jamanetwork.com/journals/jama/article-abstract/2830678 Segment 4 – Influenza Associated Encephalopathy Fazal A, Reinhart K, Huang S, et al. Reports of Encephalopathy Among Children with Influenza-Associated Mortality - United States, 2010-11 Through 2024-25 Influenza Seasons. CDC: Morbidity and Mortality Weekly Report (MMWR) Morb Mortal Wkly Rep. February 27, 2025. https://www.cdc.gov/mmwr/volumes/74/wr/mm7406a3.htm Surtees R, DeSousa C. Influenza virus associated encephalopathy. NIH: National Library of Medicine – National Center for Biotechnology Information. PMC: PubMed Central. Arch Dis Child. June 2006. https://pmc.ncbi.nlm.nih.gov/articles/PMC2082798/ Segment 5 – The Pitt Max. The Pitt | official trailer | Max. Accessed March 27, 2025. https://www.youtube.com/watch?v=ufR_08V38sQ The Pitt. Max. Accessed March 27, 2025. https://www.max.com/shows/pitt-2024/e6e7bad9-d48d-4434-b334-7c651ffc4bdf Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Episode 144 - All Aboard the Van Der Poel Express, Podium Glory for Keegan Swenson, and Did Someone Say Palm Cooling?   What up party people. We are BACK for another episode with y'all this week and let me tell you, for all the Dizzle fans and not-so-fans this one is going to be polarizing for sure. Tune in for the full show and you'll find out why. We're talking about the already hot and steamy Van der Poel train, Keegan Swenson's continued not-so-steamy performance at Cape Epic, and did you really just suggest I cool my palms for more watts on my next interval session. Oh and of course, plenty of tire talk.   Speaking of tire talk, the race season is among us which means the time is now to start stockpiling on all of your favorite tires. Or you can just ride what we suggest like all the other Karen's out there do. But either way, any and all of your go-to tires, gear, clothing, you name it can be found by perusing the vast product pages over at Bike Tires Direct and for all of our loyal listeners, you can get an extra 10% off by using the code “bonkbros” at checkout! (https://www.biketiresdirect.com/?utm_source=bonkbros&utm_medium=banner&utm_campaign=bonkbros2025)   While you're at it you can also scoop up some of our favorite Silca products like the coveted Crockpotanator4000 or their latest Ultimate Sealant 2.0. Head over to Silca.cc today and use the code “Bonkbrosgravelseason” at checkout for an extra 10% off. (https://silca.cc/?utm_source=Bonk+Bros&utm_medium=podcast&utm_campaign=stripchip&utm_id=Bonk+Bros+Podcast)   And last but not least, if you want to get your world rocked by the magic effects of ketone esthers, head over to KetoneAid today to pickup some of that Ketone heavy or Ketone light. Use the affiliate link in the show notes for free shipping. (https://ketoneaid.com/?utm_source=BonkBros)   If you have any questions or feedback for the show you can drop us a note at bonkbrospodcast@gmail.com or hit up the Bonk Bros instagram page (@bonkbros @dylanjawnson @adamsaban6 @tylerclouti @raddaddizzle @scottmcgilljr). Alright let's get this party started!   FOR UPDATED DISCOUNT CODES CHECK THE LATEST EPISODE: Silca (10% discount code: Bonkbrosgravelseason): https://silca.cc/?utm_source=Bonk+Bros&utm_medium=podcast&utm_campaign=stripchip&utm_id=Bonk+Bros+Podcast   Bike Tires Direct (10% discount code: bonkbros): https://www.biketiresdirect.com/?utm_source=bonkbros&utm_medium=banner&utm_campaign=bonkbros2025   Dynamic Cyclist (10% discount code: BONKBROS): https://new.dynamiccyclist.com/a/43703/xkYViFV8     Patreon: http://patreon.com/patreon_bonkbros     For more Dylan Johnson content: https://www.youtube.com/channel/UCIf1xvRN8pzyd_VfLgj_dow   Listener Question Form: https://docs.google.com/forms/d/1T37wGRLk6iYTCF6X_DQ9yfcaYtfAQceKpBJYR5W7DVA/edit?ts=642eb6d6   MERCH: T-SHIRTS ARE HERE! Get your Bonk Bros swag below. https://bb5a73-20.myshopify.com/    IGNITION: Hire a coach. Get faster. It's that simple. https://www.ignitioncoachco.com/   MATCHBOX PODCAST: Check out our more serious training focused podcast.  https://www.ignitioncoachco.com/podcast      The Following Was Generated Using AI And Should Not Be Held To The Higher Standards Of Sentient Beings - Riverside.   Keywords podcast, cycling, tire width, training camp, Vanderpool, race predictions, cycling dynamics, morning routines, competitive cycling, cycling insights, cycling, sprinting, race strategies, Milan San Remo, fan engagement, sports analysis, cycling highlights, bike racing, European road racing, sports culture, athlete perspective, sports fandom, team dynamics, sponsorship impact, cycling competitions, cycling, performance, climbing, marginal gains, training, tire technology, personal stories, competitive cycling, Peak Torque, cycling content, tire talk, mountain biking, cooling techniques, performance, cycling shoes, GCN, bike racing, cycling community Summary In this episode, the hosts discuss various topics ranging from morning routines and mood swings to the science behind tire width in cycling. They share insights from a recent training camp, comparing the challenges of running a camp to parenting. The conversation also touches on the competitive nature of cycling camps and culminates in a discussion about race predictions and outcomes, particularly focusing on the performance of notable cyclists like Vanderpool. In this segment, the conversation delves into the intricacies of cycling, particularly focusing on sprinting techniques, race strategies, and the excitement surrounding events like Milan San Remo. The participants analyze the decisions made by cyclists during races, the thrill of watching highlights, and the varying levels of fan engagement in cycling compared to other sports. They also draw parallels between cycling and video games, discussing how different forms of media can influence interest in sports. In this segment, the conversation delves into the perspectives of top athletes regarding their engagement with the sport when not competing, the dynamics of team partnerships, and the impact of sponsorships on their careers. The discussion also touches on upcoming competitions and the expectations surrounding them, providing insights into the cycling world. In this segment of the conversation, the hosts delve into various aspects of cycling performance, including climbing dynamics, personal connections among cyclists, the concept of marginal gains, and the impact of weight and training strategies on performance. They also discuss the marketing claims surrounding tire technology, emphasizing the skepticism that often accompanies such claims. The conversation is filled with humor and camaraderie, reflecting the personal relationships and rivalries within the cycling community. In this engaging conversation, the hosts delve into various topics related to cycling, including their thoughts on Peak Torque's content, discussions about the best mountain bike tires, and innovative cooling techniques for performance enhancement during races. The dialogue is filled with humor and camaraderie, showcasing their passion for cycling and the cycling community. Takeaways Drew's mood swings can affect podcast dynamics. Wider tires are proven to be faster on cobbles. Training camps provide unique experiences and insights. Running a camp is different from parenting, but not easier. The competitive nature of cycling camps can lead to rivalry. Race predictions can be tricky, especially with top cyclists. Vanderpool's performance is often underestimated. Morning routines can impact performance in podcasts. The camaraderie among cyclists is evident in training camps. Cycling insights can lead to better race strategies. Vanderpult's sprinting technique is unmatched. Race strategies can change the outcome of a race. Milan San Remo is unpredictable and exciting. Fan engagement varies significantly across sports. Watching highlights can be more appealing than full races. Personal connections to a sport can enhance viewing experiences. Cycling culture is different from mainstream sports culture. Video games can spark interest in real-life sports. The excitement of racing is often in the final moments. Cycling enthusiasts often prefer highlights over full broadcasts. Top athletes often remain fans of their sport even when not competing. The camaraderie among athletes can be seen when they support each other from the sidelines. Team dynamics play a crucial role in performance and success in competitions. Sponsorships can influence team pairings and athlete opportunities. Upcoming competitions generate excitement and anticipation among fans and athletes alike. Athletes' personal lives and relationships can impact their public image and performance. The cycling community is closely knit, with athletes often sharing mutual respect and admiration. Performance metrics and expectations can weigh heavily on athletes, affecting their mental state. The cycling season's timing can be puzzling, with delays in starting competitions. Athletes often joke about their peers' performance, highlighting the competitive yet humorous nature of the sport. Climbing performance is influenced by both physical attributes and group dynamics. Personal connections can form through shared experiences, even among rivals. Marginal gains are often sought by those who feel desperate to improve their performance. Weight and training strategies play a crucial role in cycling performance. Skepticism towards tire marketing claims is common among cyclists. The importance of aerodynamics in cycling cannot be overstated. Personal anecdotes can enhance the relatability of competitive cycling discussions. The cycling community often shares a blend of rivalry and camaraderie. Understanding the psychology behind performance can lead to better training outcomes. Tire technology continues to evolve, but marketing claims should be approached with caution. Peak Torque's content is genuinely interesting and well-received. The Race Kings are highly regarded for their puncture resistance. Handling and traction are critical factors when choosing mountain bike tires. The Thunderbirds are not recommended for serious mountain biking due to poor traction. The Schwalbe Racing Ralph is favored for its traction and speed. Cooling techniques can significantly impact performance during races. Using palms for cooling is more effective than ice. Perception of temperature can affect athletic performance. Innovative cooling methods, like cooling vests, are being explored. The importance of brain cooling for optimal performance is highlighted. Titles Morning Mood Swings in Cycling The Science Behind Tire Widths Insights from a Cycling Training Camp Comparing Camp Life to Parenting The Competitive Edge in Cycling Camps Race Predictions and Surprises Vanderpool: The Underrated Cyclist Morning Routines and Performance Cycling Dynamics and Strategies The Evolution of Tire Technology in Cycling Sound Bites "Drew's mood swings are crazy." "Wider tires over cobbles is faster." "We're all losers." "Wow. Cross nuts." "It was an exciting race." "I get hyped for that." "Only when you're around." "Do you think Remco watched MSR?" "Dude, he is such a cool guy." "He's so ugly dude." "Carrie Werner is anti-bonk bro." "Marginal gains are for losers." "You're not as desperate." "It's all lies." "Don't care, don't care." "That's a tread to a t-shirt." "I think CJ is going to be mad." "Peak Torque is dope." "Boom! That's what it is." "You could read this PubMed thing." Chapters 00:00 Morning Mood Swings and Podcast Dynamics 02:57 The Science of Tire Width in Cycling 05:58 Training Camp Experiences and Insights 09:01 Comparing Camp Life to Parenting 12:02 The Competitive Nature of Cycling Camps 14:59 Race Predictions and Outcomes 18:04 The Art of Sprinting in Cycling 21:01 Analyzing Race Strategies and Decisions 24:53 The Excitement of Milan San Remo 27:30 Fan Engagement in Cycling 30:03 Comparing Sports: Cycling and Video Games 37:41 The Perspective of Top Athletes 40:03 The Intersection of Performance and Popularity 42:57 The Dynamics of Team Partnerships 46:44 Sponsorships and Their Impact 49:08 Upcoming Competitions and Expectations 55:15 Climbing Dynamics and Performance 57:04 Personal Connections and Rivalries in Cycling 58:49 Marginal Gains and Competitive Mindsets 01:01:31 Weight, Performance, and Training Strategies 01:03:16 Tire Technology and Marketing Claims 01:14:44 Peak Torque and Cycling Content 01:17:10 Tire Talk: Best Options for Mountain Biking 01:29:07 Cooling Techniques for Performance 01:40:01 Wrap-Up and Final Thoughts

In this episode, we dive deep into one of nature's most powerful superfoods—colostrum—and explore its incredible benefits for immune function, gut health, and overall well-being. But we're taking it a step further by introducing Immunel, a highly concentrated and bioactive colostrum extract developed by Sterling Technology. Immunel represents the 5th generation of colostrum, setting a new standard for immune and gut support. Topics Covered:  What is Colostrum? The first milk produced after birth, rich in antibodies (IgG), growth factors, and bioactive peptides. The science behind 9,000+ PubMed studies on colostrum's health benefits.  The Health Benefits of Bovine Colostrum Immune Boosting: Clinical research shows colostrum is 3x more effective than the flu vaccine in reducing flu incidence. Gut Healing Properties: Protects the GI lining, reduces diarrhea by 86.6%, and helps in ulcerative colitis management. Anti-Inflammatory Effects: Supports those with NSAID-induced GI issues. Stem Cell & Regenerative Potential.  Immunel: The Next Evolution in Colostrum A concentrated colostrum extract packed with key bioactive compounds: Growth Factors (IGF-1, TGF-ß2) Proline-Rich Polypeptides (PRPs) for immune modulation Enzymes (lysozyme, lactoperoxidase, lactoferrin) for pathogen defense Sialic Acid & Nucleotides essential for immune function & DNA synthesis  Immunel vs. Standard Colostrum Unlike standard colostrum, which focuses on IgG content, Immunel is clinically validated for immune activation and pathogen defense. Outperforms β-glucans and vitamin C in immune response.  Scientific Evidence on Immunel Enhances phagocytosis & innate immunity Activates Natural Killer (NK) cells (↑ CD69 expression) Reduces bacterial lung infections by 70.2% Lowers viral load by 64% in influenza  Why This Matters for Public Health The economic burden of flu & colds: 75M lost workdays annually, costing $37.5B. Growing consumer interest: 47% of people prioritize immune health, driving demand for functional foods. Immunel is a next-generation, scientifically backed immune and gut health solution—more bioavailable and effective than traditional colostrum. Perfect for daily supplementation to support overall health and resilience.

The pervasive presence of microplastics and environmental toxins in our daily lives poses a growing threat to human health, with impacts ranging from hormonal disruption and metabolic dysfunction to immune system compromise and chronic inflammation. These contaminants, found in food packaging, water supplies, personal care products, and even the air we breathe, accumulate in the body and contribute to the rise in chronic diseases such as obesity, diabetes, cancer, and autoimmune conditions. Understanding their far-reaching effects is essential, but the good news is that the body has powerful detoxification mechanisms that, when properly supported through dietary choices, lifestyle adjustments, and targeted supplementation, can help mitigate their damage.  In this episode, I discuss, along with toxin-expert Dr. Joseph Pizzorno, why we need to take action to reduce toxin exposures, reverse existing damage, and build a foundation for long-term well-being. Dr. Joseph Pizzorno is a transformational leader in medicine. Through half a century of work, he has helped establish and advance the academic, scientific, and clinical protocols for natural, functional, integrative, and environmental medicine. As founding president of Bastyr University in 1978, he coined the term “science-based natural medicine” and led Bastyr to become the first-ever accredited institution in the field. He has set worldwide standards of practice by authoring or co-authoring six textbooks for doctors, including the Textbook of Natural Medicine (over 100,000 copies in 4 languages across 5 editions) and Clinical Environmental Medicine. He is Editor-in-Chief of PubMed-indexed IMCJ—the most widely read, peer-reviewed journal in the field (25,000 copies each issue). He is a founding member of the Board of Directors of the Institute for Functional Medicine, where he served three terms as Chair. A licensed naturopathic physician, educator, researcher, and expert spokesman, he is also the author or co-author of eight consumer books (most recent, Healthy Bones, Healthy You! with his wife Lara).  This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: Microplastics: What They Are, Why They are Dangerous, and How to Protect Yourself Environmental Toxins: How To Eliminate the Silent Killers with Dr. Joseph Pizzorno How To Reduce Your Environmental Toxin Exposure

On this episode of the Crazy Wisdom Podcast, host Stewart Alsop welcomes Jessica Talisman, a senior information architect deeply immersed in the worlds of taxonomy, ontology, and knowledge management. The conversation spans the evolution of libraries, the shifting nature of public and private access to knowledge, and the role of institutions like the Internet Archive in preserving digital history. They also explore the fragility of information in the digital age, the ongoing battle over access to knowledge, and how AI is shaping—and being shaped by—structured data and knowledge graphs. To connect with Jessica Talisman, you can reach her via LinkedIn.  Check out this GPT we trained on the conversation!Timestamps00:05 – Libraries, Democracy, Public vs. Private Knowledge Jessica explains how libraries have historically shifted between public and private control, shaping access to knowledge and democracy.00:10 – Internet Archive, Cyberattacks, Digital Preservation Stewart describes visiting the Internet Archive post-cyberattack, sparking a discussion on threats to digital preservation and free information.00:15 – AI, Structured Data, Ontologies, NIH, PubMed Jessica breaks down how AI trains on structured data from sources like NIH and PubMed but often lacks alignment with authoritative knowledge.00:20 – Linked Data, Knowledge Graphs, Semantic Web, Tim Berners-Lee They explore how linked data enables machines to understand connections between knowledge, referencing the vision behind the semantic web.00:25 – Entity Management, Cataloging, Provenance, Authority Jessica explains how libraries are transitioning from cataloging books to managing entities, ensuring provenance and verifiable knowledge.00:30 – Digital Dark Ages, Knowledge Loss, Corporate Control Stewart compares today's deletion of digital content to historical knowledge loss, warning about the fragility of digital memory.00:35 – War on Truth, Book Bans, Algorithmic Bias, Censorship They discuss how knowledge suppression—from book bans to algorithmic censorship—threatens free access to information.00:40 – AI, Search Engines, Metadata, Schema.org, RDF Jessica highlights how AI and search engines depend on structured metadata but often fail to prioritize authoritative sources.00:45 – Power Over Knowledge, Open vs. Closed Systems, AI Ethics They debate the battle between corporations, governments, and open-source efforts to control how knowledge is structured and accessed.00:50 – Librarians, AI Misinformation, Knowledge Organization Jessica emphasizes that librarians and structured knowledge systems are essential in combating misinformation in AI.00:55 – Future of Digital Memory, AI, Ethics, Information Access They reflect on whether AI and linked data will expand knowledge access or accelerate digital decay and misinformation.Key InsightsThe Evolution of Libraries Reflects Power Struggles Over Knowledge: Libraries have historically oscillated between being public and private institutions, reflecting broader societal shifts in who controls access to knowledge. Jessica Talisman highlights how figures like Andrew Carnegie helped establish the modern public library system, reinforcing libraries as democratic spaces where information is accessible to all. However, she also notes that as knowledge becomes digitized, new battles emerge over who owns and controls digital information​​.The Internet Archive Faces Systematic Attacks on Knowledge: Stewart Alsop shares his firsthand experience visiting the Internet Archive just after it had suffered a major cyberattack. This incident is part of a larger trend in which libraries and knowledge repositories worldwide, including those in Canada, have been targeted. The conversation raises concerns that these attacks are not random but part of a broader, well-funded effort to undermine access to information​​.AI and Knowledge Graphs Are Deeply Intertwined: AI systems, particularly large language models (LLMs), rely on structured data sources such as knowledge graphs, ontologies, and linked data. Talisman explains how institutions like the NIH and PubMed provide openly available, structured knowledge that AI systems train on. Yet, she points out a critical gap—AI often lacks alignment with real-world, authoritative sources, which leads to inaccuracies in machine-generated knowledge​​.Libraries Are Moving From Cataloging to Entity Management: Traditional library systems were built around cataloging books and documents, but modern libraries are transitioning toward entity management, which organizes knowledge in a way that allows for more dynamic connections. Linked data and knowledge graphs enable this shift, making it easier to navigate vast repositories of information while maintaining provenance and authority​​.The War on Truth and Information Is Accelerating: The episode touches on the increasing threats to truth and reliable information, from book bans to algorithmic suppression of knowledge. Talisman underscores the crucial role librarians play in preserving access to primary sources and maintaining records of historical truth. As AI becomes more prominent in knowledge dissemination, the need for robust, verifiable sources becomes even more urgent​​.Linked Data is the Foundation of Digital Knowledge: The conversation explores how linked data protocols, such as those championed by Tim Berners-Lee, allow machines and AI to interpret and connect information across the web. Talisman explains that institutions like NIH publish their taxonomies in RDF format, making them accessible as structured, authoritative sources. However, many organizations fail to leverage this interconnected data, leading to inefficiencies in knowledge management​​.Preserving Digital Memory is a Civilization-Defining Challenge: In the digital age, the loss of information is more severe than ever. Alsop compares the current state of digital impermanence to the Dark Ages, where crucial knowledge risks disappearing due to corporate decisions, cyberattacks, and lack of preservation infrastructure. Talisman agrees, emphasizing that digital archives like the Internet Archive, WorldCat, and Wikimedia are foundational to maintaining a collective human memory​​.

Send me a text! I'd LOVE to hear your feedback on this episode!Important Links:I will always support Qualia because of their quality, science and research.  Try their new magnesium and other brilliant formulations at a discount using my code sandyk - https://www.qualialife.com/.Join my Substack, where you'll get a glimpse of my upcoming book:https://sandykruse.substack.com/Gregory Kelly is VP of Product Development at Qualia Life, naturopathic physician (N.D.), and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health.Magnesium powers hundreds of essential body functions, yet roughly half of Americans don't get enough of this critical mineral for optimal cellular health, energy production, and brain function.• Magnesium serves as a cofactor in over 600 enzymatic reactions and activates 200 more processes throughout the body• Modern food production, soil depletion, and filtered water have drastically reduced our magnesium intake compared to our ancestors• Different forms of magnesium target different tissues – magnesium glycinate benefits the brain while magnesium citrate helps both brain and muscles• Common symptoms of deficiency include muscle cramps, anxiety, irritability, brain fog, fatigue, and sleep disturbances• Blood tests are poor indicators of magnesium status as 99% of the body's magnesium is stored in bones and soft tissues• A "portfolio approach" using multiple forms of magnesium ensures comprehensive support for all body systems• Magnesium works synergistically with trace minerals and boron for optimal absorption and retention• Medications like diuretics, acid blockers, and birth control pills can deplete magnesium levels• Quality control matters when selecting magnesium supplements to ensure purity and potencyUse code SANDYK at qualialife.com for 15% off Qualia Magnesium Plus, featuring nine forms of magnesium desSupport the showPlease rate & review my podcast with a few kind words on Apple or Spotify. Subscribe wherever you listen, share this episode with a friend, and follow me below. This truly gives back & helps me keep bringing amazing guests & topics every week.Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgRumble: https://rumble.com/c/c-5461001Linkedin: https://www.linkedin.com/in/sandyknutrition/Substack: https://sandykruse.substack.com/Podcast Website: https://sandykruse.ca

What would happen if the go-to resource for your CME research—PubMed—became unreliable or inaccessible? Would your workflow survive the disruption? As CME professionals, we depend on PubMed for high-quality, evidence-based research. But with looming funding changes it's time to rethink how we source medical literature. This episode unpacks the latest developments and gives you a proactive plan to safeguard your research process. Learn why PubMed's future is uncertain and what that means for CME professionals. Discover alternative medical research tools that can fill the gaps if PubMed access is disrupted. Get expert-backed strategies to diversify your literature search and stay ahead of potential research barriers. Hit play now to future-proof your CME research strategy and ensure uninterrupted access to high-quality medical literature! Time Stamps 00:00 Introduction: The Importance of PubMed for CME Professionals 00:32 Potential Threats to PubMed 02:21 Speculative Changes and Their Implications 02:40 Preparing for Potential Disruptions 03:03 Alternative Research Tools and Strategies 04:06 Staying Informed and Connected 04:26 Conclusion and Call to Action Resources Europe PMC – A free resource for accessing biomedical literature, serving as an alternative to PubMed. Wayback Machine – A digital archive that allows retrieval of past versions of web pages, including government health pages. DeepDyve – A subscription-based service that archives PubMed files daily and provides access to research papers. EU Clinical Trials Register – A database of clinical trials conducted in Europe, cross-referenced with ClinicalTrials.gov. Leave a voice note for Alex

Are you spending hours researching your symptoms, only to feel more overwhelmed, confused, and stuck? You're not alone. In this episode, we're breaking down why excessive research could actually be making your health worse and what you should be doing instead. Many women turn to Google, PubMed, or even ChatGPT for answers about their gut health, hormones, and chronic symptoms. But if all that research isn't leading to action, empowerment, and clarity, it's likely fuelling anxiety and keeping you stuck in a cycle of fear and inaction. What You'll Learn in This Episode: Why researching your symptoms can actually make your health worse How the wrong kind of research fuels fear, overwhelm, and nervous system dysregulation The difference between productive research and research that keeps you stuck How to gather the RIGHT kind of data so you can actually start healing Why personalised data, lab testing, and tracking your unique symptoms are game changers Resources Book your free call with me here If you want to work with me, I have spaces in my new program, Bloom. Beat the Sweet: Sugar Detox & Recipe Collection

Dr. Michael Haley discusses where artificial intelligence is now and where it is going. He lets Gemini AI guest host the Dr. Haley Show Podcast. Listen to Gemini Interview Dr. Michael Haley about aloe vera and it's many uses. After the artificial interview, Dr. Haley discusses how eventually people will have artificial relationships with brain implants stimulating the senses making the virtual relationship feel better than real life.RESOURCES:Buy Aloe Vera:https://haleynutrition.com/Visit this episodes Show Page:https://drhaley.com/artificial-intelligence-intimacy/Pubmed:https://pubmed.ncbi.nlm.nih.gov/Google Scholar:https://scholar.google.com/TIMESTAMPS:00:00:00 Intro Snip00:00:55 Introduction to the episode00:01:30 Where is AI today?00:01:53 How do robots use artificial intelligence?00:02:30 When will we have our own robots and how much will they cost?00:02:48 What will the robot do for us?00:03:58 Will robots ever be alive?00:04:47 What is the format of this podcast episode?00:05:00 What is Gemini Live?00:05:58 Gemini starts the podcast interview "What is aloe vera and where does it come from?"00:06:34 What are the benefits of aloe vera?00:08:22 How is aloe vera used?00:09:08 What are the nutrients in aloe vera?00:10:01 How does aloe vera help regulate blood sugar levels?00:11:03 What is the research done on dogs with fibrosarcomas taking acemannan00:12:10 What are some common conditions treated with aloe vera?00:14:10 How to find a good aloe vera product00:14:46 where can I find scientific information about using aloe vera for treating certain conditions?00:15:20 what is there on pubmed for acid reflux00:15:45 what is on pubmed regarding using aloe vera for diabetes?00:16:25 what is on pubmed regarding aloe vera for cancer?00:18:40 How do you use aloe vera from the plant?00:19:28 How can I learn to extract the aloe vera gel from the plant00:20:45 Is aloe vera good in smoothies?00:21:23 Is there a benefit to having aloe vera with your supplements?00:25:15 how artificial intelligence is interfering with real relationships00:26:10 how will artificial intelligence replace intimate relationships?

About our Guest: Dr. Philip C. Spinella is a professor in the Departments of Surgery and Critical Care Medicine and the Director of the Trauma and Transfusion Medicine Research Center at the University of Pittsburgh. He also co-founded the THOR network for trauma and hemostasis research and has as been involved with multiple nationally-funded research programs.References:Use of whole blood in pediatric trauma: a narrative review - PubMed (nih.gov)Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital - PubMed (nih.gov)Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative - PubMed (nih.gov)Whole Blood Transfusion - PubMed (nih.gov)Pediatric traumatic hemorrhagic shock consensus conference recommendations - PubMed (nih.gov)Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial - PubMed (nih.gov)Precision Platelet Transfusion Medicine is Needed to Improve Outcomes - PubMed (nih.gov)Just chill—it's worth it! (wiley.com)Questions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

ORDER MY NEW BOOK SWEET INDULGENCE!!! https://www.amazon.com/Chef-AJs-Sweet-Indulgence-Guilt-Free/dp/1570674248 or https://www.barnesandnoble.com/w/book/1144514092?ean=9781570674242 GET MY FREE INSTANT POT COOKBOOK: https://www.chefaj.com/instant-pot-download Disclaimer: This podcast does not provide medical advice. The content of this podcast is provided for informational or educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health issue without consulting your doctor. Always seek medical advice before making any lifestyle changes. The science behind plant-predominant whole-food nutrition, joyful movement, and restorative sleep in enhancing quality of life and promoting recovery. From Evidence to Wellness: Integrative Medicine Approaches for Living Well with Cancer In this enlightening episode, Chef AJ welcomes Dr. Michelle Loy, MD, DipABOIM, DipABLM, DABMA, FAAP, a trailblazing physician in integrative and lifestyle medicine, to discuss how evidence-based, patient-centered, holistic approaches can enhance quality of life for those living with cancer. Dr. Loy delves into her innovative work and shares practical tips for incorporating nutrition, mind-body practices, and other integrative therapies into conventional state-of-the-art cancer care. Dr. Loy is a board-certified physician in Integrative Medicine, Lifestyle Medicine, Medical Acupuncture, and Pediatrics. She serves as an Assistant Professor at Weill Cornell Medicine/NewYork-Presbyterian Hospital, where she provides consultations addressing complex medical issues across all ages. A Harvard graduate with an MD from Cornell, Dr. Loy completed her Integrative Medicine fellowship at Columbia University/Stamford Hospital and earned Medical Acupuncture certification from SUNY Downstate Medical Center and the American Board of Medical Acupuncture. Her dedication to advancing integrative health is reflected in her leadership roles with the AAP Section of Integrative Medicine, American Board of Integrative Medicine, and the American College of Lifestyle Medicine. Insights into the evidence surrounding medical cannabis, culinary mushrooms, herbs, and botanicals for individuals facing cancer, including guidance on their appropriate use. The dangers of cancer misinformation, emphasizing the importance of seeking trusted, credible, evidence-based information, and guidance on discerning reliable resources. Complete list of published works at PubMed at: https://www.ncbi.nlm.nih.gov/myncbi/michelle.loy.1/bibliography/public/ More About Dr. Loy: Dr. Loy is a Lecturer for the Plant-Based Nutrition Certificate Program at Cornell University and serves on the medical advisory board of Plant Powered Metro New York. Her "Shop with the Doc" Culinary Medicine series and Virtual Shared Medical Appointments have been transformative for patients, offering innovative, evidence-based solutions for better health. In her free time, Dr. Loy enjoys exploring farmer's markets, cooking plant-forward meals for her husband and five children, and staying active through running and yoga. Follow Dr. Michelle Loy: Weill Cornell Profile: https://weillcornell.org/michelle-h-loy-md Getting to Know Dr. Loy - Weill Cornell News: https://weillcornell.org/news/getting-to-know-michelle-loy-md-of-integrative-health-and-wellbeing Doximity: https://www.doximity.com/pub/michelle-loy-md

About our Guest: Dr. Philip C. Spinella is a professor in the Departments of Surgery and Critical Care Medicine and the Director of the Trauma and Transfusion Medicine Research Center at the University of Pittsburgh. Dr. Spinella is a well-established clinical trialist who has published extensively in the field and contributed to research programs for the FDA, NIH, and DoD. He also co-founded the THOR network for trauma and hemostasis research and has been involved with multiple nationally funded research programs.References:Use of whole blood in pediatric trauma: a narrative review - PubMed (nih.gov)Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital - PubMed (nih.gov)Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative - PubMed (nih.gov)Whole Blood Transfusion - PubMed (nih.gov)Pediatric traumatic hemorrhagic shock consensus conference recommendations - PubMed (nih.gov)Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial - PubMed (nih.gov)Precision Platelet Transfusion Medicine is Needed to Improve Outcomes - PubMed (nih.gov)Just chill—it's worth it! (wiley.com)Questions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

Show Notes for Episode 42 of “The 2 View” – Pink cocaine, holiday heart syndrome, pertussis, research updates on Zepbound and Semaglutide, and much more. Segment 1 – Pink cocaine What is Pink Cocaine? Dea.gov. DEA: United States Drug Enforcement Administration. https://www.dea.gov/pink-cocaine What is Pink Cocaine? Poison.org. POISON CONTROL: National Capital Poison Center. https://www.poison.org/articles/pink-cocaine Segment 2 – Holiday heart syndrome Blackburn R, Ajetunmobi O, Mc Grath-Lone L, et al. Hospital admissions for stress-related presentations among school-aged adolescents during term time versus holidays in England: weekly time series and retrospective cross-sectional analysis. BJPsych Open. Cambridge University Press. Cambridge Core. Published November 19, 2021. https://www.cambridge.org/core/journals/bjpsych-open/article/hospital-admissions-for-stressrelated-presentations-among-schoolaged-adolescents-during-term-time-versus-holidays-in-england-weekly-time-series-and-retrospective-crosssectional-analysis/924EE2CD1A8CFAC30E7090674FCEAF72 Carey M, Al-Zaiti S, Kozik T, Pelter M. Holiday Heart Syndrome. ECG Puzzler. Researchgate.net. AJCC: American Journal of Critical Care. American Association of Critical-Care Nurses. https://www.researchgate.net/profile/Mary-Carey/publication/260446497HolidayHeart_Syndrome/links/573dda6308ae298602e6d0b1/Holiday-Heart-Syndrome.pdf Ettinger P, Wu C, De La Cruz Jr C, Weisse A, Ahmed S, Regan T. Arrhythmias and the “Holiday Heart”: Alcohol associated cardiac rhythm disorders. Sciencedirect.com. ScienceDirect. American Heart Journal. https://www.sciencedirect.com/science/article/abs/pii/000287037890296X Greenspon AJ, Schaal SF. The “holiday heart”: electrophysiologic studies of alcohol effects in alcoholics. Ann Intern Med. PubMed. NIH: National Library of Medicine: National Center for Biotechnology Information. Published February 1983. https://pubmed.ncbi.nlm.nih.gov/6824246/ Jain A, Yelamanchili V, Brown K, Goel A. Holiday Heart Syndrome. Nih.gov. NIH: National Library of Medicine: National Center for Biotechnology Information. Updated January 16. 2024. https://www.ncbi.nlm.nih.gov/sites/books/NBK537185/ Joglar JA, Chung MK, Armbruster AL, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. AHA | ASA Journals. Published November 30, 2023. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001193 Segment 3 – Pertussis CDC. About Whooping Cough. Whooping Cough (Pertussis). Updated April 2, 2024. https://www.cdc.gov/pertussis/about/index.html Center for Drug Evaluation, Research. FDA Drug Safety Communication: Death resulting from overdose after accidental ingestion of Tessalon (benzonatate) by children under 10 years of age. FDA: U.S. Food and Drug Administration. Published June 28, 2019. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-death-resulting-overdose-after-accidental-ingestion-tessalon Pertussis. Who.int. World Health Organization. https://www.who.int/health-topics/pertussis Simma L, Gesch M. Eyelid Ecchymoses and Subconjunctival Hemorrhage in Pertussis. N Engl J Med. Published December 11, 2024. https://www.nejm.org/doi/full/10.1056/NEJMicm2409052 Something sweet – Research updates: Zepbound and Semaglutide Ernst D. Zepbound Approved for Obstructive Sleep Apnea in Patients With Obesity. Monthly Prescribing Reference. MPR: Medical Professionals Reference. Published December 20, 2024. https://www.empr.com/news/zepbound-approved-for-obstructive-sleep-apnea-in-patients-with-obesity/?utmsource=eloqua&utmmedium=email&utmcampaign=NWLTRMPRTOPTDrug-DatabaseSS-LAS-LI1-LI2-9654122924_AL&hmemail=1f%2FJfEV7hN5vJr6vg%2FQRqK0NA6IXtyO3&sha256email=092493d8223fdfa40d9e995176d13e5fc5b5211674db9deb440c025fd462c80c&hmsubid=&nid=1639413404&elqtrack=True Semaglutide shows promise as a potential alcohol use disorder medication. Research Update. Nih.gov. NIH: National Institute on Alcohol Abuse and Alcoholism. Published March 13, 2024. https://www.niaaa.nih.gov/news-events/research-update/semaglutide-shows-promise-potential-alcohol-use-disorder-medication Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share! Looking forward to another year together!

“So, for people who might think, ‘You see, the vegan diet is too expensive'—no. You can get frozen fruits and vegetables too if you can't get the fresh ones. Absolutely, absolutely. This is true. And I'll do a tangent on your tangent. One of the things that I always recommend to people when I've done nutrition coaching in the past is, if they're price-sensitive, getting dried legumes and dried beans. They are some of the most nutrient-dense and cost-effective things you can buy.” -Alexandra Paul and Jason Wrobel How much cardiovascular exercise do you really need? What's the truth about soy, cholesterol, and daily protein intake? In this episode, Alexandra and Jason cut through the confusion, tackling the dangers of visceral fat, the surprising science behind intermittent fasting and autophagy, and the truth about frozen versus fresh produce. Plus, we uncover the hidden risks of alcohol, including its link to cancer, how acetaldehyde affects your body, and so much more. Tune in for a no-nonsense dive into the facts that matter for your health! Podcast sponsor: Vedge Vegan Collagen: vedgenutrition.com – use code S4G for 30% off your order. - https://www.vedgenutrition.com/ What we discuss in this episode: The impact of exercise on all-cause mortality. Essential foods you should be eating every day for optimal health. Why consistent movement is key to long-term well-being. Tips for reducing gas production from beans. Intermittent fasting vs. extended fasting—key differences and benefits The French Paradox. How alcohol contributes to gout and ways to manage risk.  Resources: Episode #289: Can Fasting Save Your Life? with Dr. Alan Goldhamer Physical activity and dietary behavior in US adults and their combined influence on health - PubMed. The Role of Diet Compared to Physical Activity on Women's Cancer Mortality: Results From the Third National Health and Nutrition Examination Survey - PubMed U.S. Surgeon General Calls for Cancer Warnings on Alcohol - The New York Times Who is the oldest person in the world in 2024? | BBC Science Focus Magazine Click the link below to support the ADD SOY Act https://switch4good.org/add-soy-act/ Share the website and get your resources here https://kidsandmilk.org/ Send us a voice message and ask a question. We want to hear from you! Switch4Good.org/podcast Dairy-Free Swaps Guide: Easy Anti-Inflammatory Meals, Recipes, and Tips https://switch4good.org/dairy-free-swaps-guide SUPPORT SWITCH4GOOD https://switch4good.org/support-us/ ★☆★ JOIN OUR PRIVATE FACEBOOK GROUP ★☆★  https://www.facebook.com/groups/podcastchat ★☆★ SWITCH4GOOD WEBSITE ★☆★ https://switch4good.org/ ★☆★ ONLINE STORE ★☆★ https://shop.switch4good.org/shop/ ★☆★ FOLLOW US ON INSTAGRAM ★☆★ https://www.instagram.com/Switch4Good/ ★☆★ LIKE US ON FACEBOOK ★☆★ https://www.facebook.com/Switch4Good/ ★☆★ FOLLOW US ON TWITTER ★☆★ https://twitter.com/Switch4GoodOrg ★☆★ AMAZON STORE ★☆★ https://www.amazon.com/shop/switch4good ★☆★ DOWNLOAD THE ABILLION APP ★☆★ https://app.abillion.com/users/switch4good

In this special edition of Diabetes Core Update, host Neil Skolnik, MD, explores the timely and critical topic of compounded medications in diabetes care. In this episode Dr. Skolnik moderates a discussion between a family doctor, a patient, and a pharmacist about practical decision making around the topic of compounded medication for the treatment of overweight and obesity. This special edition of Diabetes Core Update is supported by Lilly. Presented by: Neil Skolnik, MD – Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington–Jefferson Health John Hertig, PharmD, MS, CPPS – Associate Professor, Butler University College of Pharmacy and Health Sciences Susan Kuchera, MD - Clinical Assistant Professor of Family and Community Medicine at the Sidney Kimmel Medical College of Thomas Jefferson University and Program Director of the Family Medicine Residency at Jefferson Health Abington. Lisa Kessler MS, CCC-SLP - Infant-toddler Homebased Pediatric Speech-Language Pathologist Compounded GLP 1 and Dual GIP/GLP 1 Receptor Agonists: A Statement from the American Diabetes Association. Diabetes Care December 2, 2024;  dci240091 https://doi.org/10.2337/dci24-0091 PubMed: 39620926 FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss.  US FDA Website ( current as of 12/18/2024)

Dr. Don and Professor Ben talk about the risks from sticking energy chews to a bike's frame for easy access. Dr. Don - not risky

"The endocannabinoid system regulates all these other systems."  -Will KleidonSri learns *all* about CBD from futurist and entrepreneur Will Kleidon (LinkedIn). Will is the founder and CEO of Ojai Energetics, the first company to create organic, water-soluble CBD, which also has third-party testing that is traceable to the lot on your product. Will goes deep into the science of CBD in terms of human benefits, affects on pets, and safe manufacturing. He and Sri cover uses for: PTSDbetter sleeppeak performanceThey also cover: the best recipe for flow states (caffeine + CBD)what the endocannabinoid system (ECS) is and how it worksthe neuroscience of CBDreduction of inflammationquantum biologyRhabdomyolysis (Rabdo)early agriculturehow all vertebrates have an ECSCheck out the research for yourself on Pubmed. #cannabinoids, CBD, THC, health, recovery, exercise, inflammation, wellness, endocannabinoid system, quantum biology, flow state, PTSD, neuroscience, neurodiversity, health benefits, serum, stress response

*Top 10 List: Fred Williams and co-host Doug McBurney review their list of the top 10 things people still believe, that science has proven wrong. #10: Vestigial Organs -  The most popular one growing up was the appendix, remember? Until this (from PubMed in 2016). And don't forget tonsils!  #9: GPS won't work without Einsteinian relativity. It will, and does. #8: Junk DNA - There's no such thing! We're only beginning to comprehend DNA. And to have ever assumed any of it was junk was foolishness! #7: Lucy is a Human Ancestor - Poppycock! #6: Plate Tectonics - The fourth-biggest-dumbest theory going, (after Darwinian Evolution, the Big Bang, and Einsteinian Relativity). #5: Dangerous Anthropogenic Climate Change - Fifth biggest-dumbest... #4: Darwin's Tree of Life - That dog don't hunt, and lies like a rug! #3: The Big Bang: See #'s 4 & 5, the James Webb Space Telescope, and our favorite! Genesis One. #2: Evolution: Ha! Yeah.... right! (Also, see Genesis One again). Neo-Darwinism is so laughably preposterous even foolish atheists like Jimmy Shapiro are beginning to re-evaluate the emperor's outfit.  #1: Dinosaurs lived and went extinct millions of years ago. We've long had solid evidence that man and dinosaurs lived together, from cliff and cave drawings to the tomb of Richard Bell, to Chinese calendars... and of course all that dinosaur soft tissue in all those fossils!

*Top 10 List: Fred Williams and co-host Doug McBurney review their list of the top 10 things people still believe, that science has proven wrong. #10: Vestigial Organs -  The most popular one growing up was the appendix, remember? Until this (from PubMed in 2016). And don't forget tonsils!  #9: GPS won't work without Einsteinian relativity. It will, and does. #8: Junk DNA - There's no such thing! We're only beginning to comprehend DNA. And to have ever assumed any of it was junk was foolishness! #7: Lucy is a Human Ancestor - Poppycock! #6: Plate Tectonics - The fourth-biggest-dumbest theory going, (after Darwinian Evolution, the Big Bang, and Einsteinian Relativity). #5: Dangerous Anthropogenic Climate Change - Fifth biggest-dumbest... #4: Darwin's Tree of Life - That dog don't hunt, and lies like a rug! #3: The Big Bang: See #'s 4 & 5, the James Webb Space Telescope, and our favorite! Genesis One. #2: Evolution: Ha! Yeah.... right! (Also, see Genesis One again). Neo-Darwinism is so laughably preposterous even foolish atheists like Jimmy Shapiro are beginning to re-evaluate the emperor's outfit.  #1: Dinosaurs lived and went extinct millions of years ago. We've long had solid evidence that man and dinosaurs lived together, from cliff and cave drawings to the tomb of Richard Bell, to Chinese calendars... and of course all that dinosaur soft tissue in all those fossils!

Are you trying to lower inflammation? Maybe you've got to kill those senescent (aka Zombie) cells to accelerate healing. Learn all about how senolytics taken just once a month and other hacks can add life to your years by helping the body clear cells that are old, yet don't know how to die.  Naturopathic physician, senolytic expert and SVP of Product Development at Qualialife Gregory Kelly explains the science behind senescent cells. Dr. Kelly was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships.  Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. We cover: Senescent cells, zombie cells How to get rid of them Who needs to be concerned about senescent cell build up What it means What's better - fasting or supplements What women in peri and post menopause need to know about senescent cells Senescent cells and menopause Incredible results for women with joint pain and fatigue   Get qualialife.com/hackmyage code HACKMYAGE 15% off Contact Gregory Kelly and Qualia: Website: https://qualialife.com/hackmyage Facebook: https://www.facebook.com/Qualialife  Instagram: https://www.instagram.com/qualialife/  LinkedIn: https://www.linkedin.com/in/gregory-kelly-98b96b138/   Give thanks to our sponsors Qualia senolytics and brain supplements. 15% off with code ZORA here.  Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.  Get Mitopure Urolithin A by Timeline. 10% discount with code ZORA at https://timeline.com/zora Visit https://getkion.com/zora for 20% off Kion Essential Amino Acids Try OneSkin skincare for with code ZORA at https://shareasale.com/r.cfm?b=2685556&u=4476154&m=102446&urllink=&afftrack= Join ⁠⁠⁠Biohacking Menopause⁠⁠⁠ before February 1, 2025 to win Kion Essential Amino Acids. 20% off with code ZORA at https://getkion.com/zora https://biohacking-menopause.mn.co Join the Hack My Age community on: Facebook Page : ⁠⁠⁠⁠⁠@⁠Hack My Age⁠   Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠   Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠   ⁠Membership group: Biohacking Menopause⁠ Email: zora@hackmyage.com This podcast is edited by ⁠⁠⁠⁠⁠jonathanjk@gmail.com

Show Notes for Episode 41 of “The 2 View” – reversible cerebral vasoconstriction syndrome, cerebral venous thrombosis, cardiopulmonary resuscitation and emergency cardiovascular care science, prehospital tourniquets, blood pressure, and more. Segment 1 – Reversible cerebral vasoconstriction syndrome and cerebral venous thrombosis Ropper AH, Klein JP. Cerebral Venous Thrombosis. N Engl J Med. Published June 30, 2021. https://www.nejm.org/doi/full/10.1056/NEJMra2106545 Spadaro A, Scott KR, Koyfman A, Long B. Reversible cerebral vasoconstriction syndrome: A narrative review for emergency clinicians. Am J Emerg Med. ScienceDirect. Published December 2021. https://www.sciencedirect.com/science/article/abs/pii/S0735675721008093 Segment 2 – Cardiopulmonary resuscitation and emergency cardiovascular care science, Prehospital tourniquets, and more Greif R, Bray JE, Djärv T, et al. 2024 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations: Summary from the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; And First Aid Task Forces. Circulation. AHA | ASA Journals. Published November 14, 2024. https://www.ahajournals.org/doi/10.1161/CIR.0000000000001288?utmcampaign=sciencenews24-25&utmsource=science-news&utmmedium=phd-link&utmcontent=phd-11-14-24 Roberts M, Sharma M. The Center for Medical Education. 36 - Marijuana, Sunburns, Pulse Oximetry, Lower UTI's. 2 View: Emergency Medicine PAs & NPs. Published May 31, 2024. https://2view.fireside.fm/36 Roberts M, Sharma M. The Center for Medical Education. The 2 View: Episode 2. 2 View: Emergency Medicine PAs & NPs. Published February 3, 2021. https://2view.fireside.fm/2 Smith AA, Ochoa JE, Wong S, et al. Prehospital tourniquet use in penetrating extremity trauma: Decreased blood transfusions and limb complications. J Trauma Acute Care Surg. NIH: National Library of Medicine: National Center for Biotechnology Information. PubMed. Published January 2019. https://pubmed.ncbi.nlm.nih.gov/30358768/ STB home page. Stop the Bleed. American College of Surgeons. https://www.stopthebleed.org/ Teixeira PGR, Brown CVR, Emigh B, et al. Civilian Prehospital Tourniquet Use Is Associated with Improved Survival in Patients with Peripheral Vascular Injury. J Am Coll Surg. NIH: National Library of Medicine: National Center for Biotechnology Information. PubMed. Published May 2018. https://pubmed.ncbi.nlm.nih.gov/29605726/ Segment 3 – Blood Pressure Bress AP, Anderson TS, Flack JM, et al. The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association. Hypertension. NIH: National Library of Medicine: National Center for Biotechnology Information. PubMed. Published August 2024. https://pubmed.ncbi.nlm.nih.gov/38804130/ Liu H, Zhao D, Sabit A. Arm Position and Blood Pressure Readings: The ARMS Crossover Randomized Clinical Trial. Jamanetwork.com. JAMA Network. JAMA Internal Medicine. Published October 7, 2024. https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2824754 Recurring Sources Center for Medical Education. Ccme.org. http://ccme.org The Proceduralist. Theproceduralist.org. http://www.theproceduralist.org The Procedural Pause. Emergency Medicine News. Lww.com. https://journals.lww.com/em-news/blog/theproceduralpause/pages/default.aspx The Skeptics Guide to Emergency Medicine. Thesgem.com. http://www.thesgem.com Trivia Question: Send answers to 2viewcast@gmail.com Be sure to keep tuning in for more great prizes and fun trivia questions! Once you hear the question, please email us your guesses at 2viewcast@gmail.com and tell us who you want to give a shout-out to. Be sure to listen in and see what we have to share!

Today we start with an ask your coach question: is heel striking bad? Then we get into how to increase running mileage safely (specifically for distance running). You've probably heard conflicting responses, so today we take a dive into each! • heel striking , over-striding • how to increase running mileage safely

Every other week I'm republishing one of my most popular or impactful episodes and adding an update, new insight, or context that will help you benefit from it even more. This week I'm highlighting Episode 184, where I take you through my eight favorite online tools for nursing school that help set you up for success. NEWLY ADDED! Organize your school and study schedules with My Study Life. Get Google Drive with a free Google account: Google Drive. Say goodbye to password frustrations with LastPass. Take your notes for nursing school into digital format with GoodNotes and Notability. Improve your writing with Grammarly. Start your online search for research articles with Google Scholar and PubMed. Manage your bibliography and make writing scholarly papers easier with Zotero. Demystify APA formatting and scholarly writing with Purdue Owl APA. Reclaim your focus and embark on powerful work sessions with the Focus Keeper App for iOS or Pomodoro Timer for Android. ———— Full Transcript – Read the article FREE CLASS – If all you've heard are nursing school horror stories, then you need this class! Join me in this on-demand session where I dispel all those nursing school myths and show you that YES…you can thrive in nursing school without it taking over your life! Crucial Concepts Bootcamp – Start nursing school ahead of the game, or reset after a difficult first semester with my nursing school prep course, Crucial Concepts Bootcamp. Learn key foundation concepts, organization and time management, dosage calculations, and so much more. New Nursing Student Checklist – Grab this checklist which includes clinical and school supplies, things to organize, what to review, and more to help you prepare for nursing school.

I have long followed the work of Dr. Margaret McCartney. She is a general practitioner in Glasgow, Scotland, writer, public speaker, and now PhD. She is a fierce advocate for evidence-based medicine. She holds highly skeptical views of screening for disease—which, to my surprise is quite common in the UK. Her recently finished PhD sought empirical evidence regarding declaration of conflicts of interest in the UK. Here is a link to the document. Screening for atrial fibrillation is a focus of this work. Here is a link to her PubMed listing. We had a nice conversation about all things evidence and conflicts. I learned a lot about the health system in the UK. As an added bonus, Dr. M is also an avid cyclist. As always, thank you for your support of Sensible Medicine. This support allows us to bring medical content free of industry advertising. JMM Sensible Medicine is a reader-supported publication. To receive new posts and support our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

In this episode, Shintaro learns about peer review from Peter. They tackle common misconceptions, explain how peer review parallels qualifying rounds for Judo competitions, and discuss the strengths and flaws of the system. From navigating PubMed to addressing the challenges of reviewer anonymity, this episode offers an engaging and accessible take on an often misunderstood topic. Whether you're a researcher, a student, or just curious about how science works behind the scenes, this discussion will leave you with a clearer understanding of what makes peer-reviewed research tick. (00:00:00) Introduction (00:00:56) PubMed and Its Role (00:04:02) Understanding Peer Review on PubMed (00:05:41) Comparing Journals: The "Olympics" of Academia (00:08:41) How Peer Review Works: Submission to Acceptance (00:13:12) The Role of Peer Reviewers (00:16:02) Challenges of Reviewer Anonymity (00:21:34) The Debate Around Funding and Conflicts of Interest If you're in business, then you have customer churn. Whether you're building a startup, growing a mom & pop shop, or operating in a fortune 500 powerhouse, Hakuin.ai measures, predicts, and improves your customer retention. https://hakuin.ai

We're doing a deep dive into NAD, a molecule that has received a lot of attention but still confuses many of us, clinicians included. My guest today is able to unpack the complexities of NAD in a way you'll find extremely illuminating and useful. I'm excited to have Dr. Greg Kelly Senior Director of Product Development at Qualia, back with us, explaining how NAD is foundational for energy, longevity, and overall cellular health. Dr. Kelly brings clarity to how NAD influences mitochondrial function, DNA repair, and pretty much all of the hallmarks of aging. Yet, problematically, it declines as we age. This episode will cover different NAD compounds, how deficiency might present clinically, and how to measure NAD reliably. Have a listen and get ready to expand your understanding around this essential compound. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Greg Kelly greg@neurohacker.com Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health. THANKS TO OUR SPONSOR Qualia: http://www.qualialife.com/drkarafitzgerald EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Visit http://www.qualialife.com/drkarafitzgerald to try Qualia NAD+ up to 50% off and use code DRKARAFITZGERALD at checkout for an additional 15% off your entire purchase! CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw