Podcasts about Rockefeller University

Wanting to support your growing ADHD kid and knowing how to support them are often two very different things. As teens and young adults push for independence, even well-meaning advice can feel controlling, creating more resistance and disconnection. In this episode, Dr. Zach Gershon explains why peer support and community can be life-changing for young adults with ADHD, and how parents can shift from managing their child to becoming a trusted source of support. Press play to discover how connection, autonomy, and small wins can help young adults build confidence and move forward on their own terms.What to expect in this episode:Why peer support groups can feel safer and more relatable than parent adviceHow “asking instead of telling” changes parent-child dynamicsWhat ADHD teens and young adults really want from their parents during transition yearsThe role of community in reducing shame and isolation for ADHD young adultsWhy support works best when young adults feel ownership and autonomyAbout Dr. Zachary GershonDr. Zachary Gershon is a twice-exceptional neuroscientist based in New York City whose work explores the intersection of neurodiversity, cognition, and human behavior. He earned his PhD from The Rockefeller University, where his research focused on neuroscience and brain function. Drawing from both scientific expertise and lived experience as a twice-exceptional individual, Dr. Gershon is passionate about advancing conversations around neurodivergence, learning differences, giftedness, and mental performance through research, speaking, and advocacy.​Connect with Dr. ZacharyWebsite: ADHD Support Group for Young Adults | ADDA Get your FREE copy of 12 Key Coaching Tools for Parents at https://impactparents.com/gift.​Connect with Impact Parents:Instagram: https://www.instagram.com/impactparentsFacebook: https://www.facebook.com/ImpactParentsLinkedIn: https://www.linkedin.com/company/impactparentsSponsors"Cognitive Ergonomics from the Inside Out" – A New ADHD InterventionDo you recognize current ADHD interventions fall short? At DIG Coaching, we've developed a groundbreaking field of engineering called Cognitive Ergonomics from the Inside Out. Discover a fresh approach to ADHD care that looks beyond traditional methods.Learn more at www.cognitive-ergonomics.com

In this episode of Capital for Good we speak with Bob Steel, partner and vice chairman of Perella Weinberg Partners, whose career has spanned the pinnacles of business, government and nonprofit leadership. Following nearly three decades at Goldman Sachs, Steel held senior roles at the US Treasury, as Under Secretary for Domestic Finance under President George W. Bush, and in New York City government as Deputy Mayor for Economic Development under Mike Bloomberg; was CEO of Wachovia Corporation and Perella Weinberg; and along the way has served on numerous boards, corporate and civic, including at major universities like Duke, important ideas and policy organizations like the Aspen Institute, and several of New York City's anchor institutions. We begin with some of the formative individuals and institutions that would shape Steel's trajectory: his parents, who set an example of service to their North Carolina community; the attention of Dr. Joel Fleishman, a Duke Professor who challenged Steel to become a more engaged student; and the opportunity to join Goldman Sachs in 1976 when John Whitehead and John Weinberg took over the leadership of the firm. "I got on the bus at the right time," Steel says. Steel describes what it was like to work at Goldman Sachs in a period of extraordinary growth and globalization. Over close to three decades, he built several businesses across the US and Europe — "multiple careers in one institution" — and ultimately served as the firm's vice chairman and member of its management committee. "The moral of the story," he observes, "is that well-led firms that are growing create opportunities that are pretty special." In 2006, at the urging of fellow Goldman Sachs partner — and recently confirmed US Treasury Secretary Hank Paulson — Steel went to Treasury to serve as Under Secretary for Domestic Finance. Within a year, the country was in the throes of the financial crisis, and with the support of Paulson and Fed Chair Ben Bernanke, Steel and his colleagues labored to prevent the worst impacts of the crisis on the American people, and to begin to steer the economy to more stable ground. After Treasury, Steel returned to the private sector as CEO of Wachovia, where he led the bank's sale to Wells Fargo. Soon after Mike Bloomberg recruited him to serve as Deputy Mayor for Economic Development, where he would oversee the administration's five borough economic development strategy and job creation efforts across more than a dozen city agencies: tens of thousands of employees and billions of dollars in annual operating budgets. We discuss a number of the major initiatives that Steel and the Bloomberg team undertook, among them the creation of the Cornell Technion campus, today a center of applied science in the city and region. We also discuss Mayor Bloomberg's vision for long-term investments, and the latitude given to an exceptional and collegial cohort of talented commissioners. "It might be my best job ever, I learned so much," Steel says. Through these experiences, Steel has come to understand the distinct but complementary roles of the private, public, and nonprofit sectors, and their respective and mutually supportive "vectors of leverage." "You can't have successful business without government," he believes, "and you can't have good government without successful businesses. And then you add NGOs that provide exceptional seasoning and consciousness that is beneficial." Although no longer at city hall, Steel remains deeply involved in the life of the city, with board roles at Lincoln Center, Rockefeller University, the Hospital for Special Surgery, the Economic Club of New York, the Partnership for New York City, The Morgan Library, and the New York Climate Exchange. We touch on New York's recovery from the pandemic; why some of today's challenges, including affordability, are a function of the city's success (i.e., not enough housing for all the people who want to be in New York); the competition from smaller cities across the country as attractive places to live and work; and the opportunity and imperative to make long-term investments in the city's future: schools, infrastructure, arts, parks, among them.  We conclude where the conversation began: "I'm so appreciative of the organizations and people that helped me grow," Steel says. "If you did a balance of trade, I've gained so much more than I gave that I feel incredibly fortunate."   Mentioned in this episode: Cornell Tech  

Alan's Soap https://AlansSoaps.com/ToddHonor John's memory and the legacy he created for Ian and Alan with Alan's Artisan Soaps “John's Favorites” bundle.  Get one bar of each of his favorites for only $28.99. Bulwark Capital https://KnowYourRiskPodcast.comBe confident in your portfolio with Bulwark! Schedule your free Know Your Risk Portfolio review. Go to KnowYourRiskPodcast.com today. Renue Healthcare https://Renue.Healthcare/ToddYour journey to a better life starts at Renue Healthcare. Visit https://Renue.Healthcare/Todd Bonefrog https://BonefrogCoffee.com/ToddGet the new limited release, The Sisterhood, created to honor the extraordinary women behind the heroes. Use code TODD at checkout to receive 10% off your first purchase and 15% on subscriptions.LISTEN and SUBSCRIBE at:The Todd Herman Show - Podcast - Apple PodcastsThe Todd Herman Show | Podcast on SpotifyWATCH and SUBSCRIBE at: Todd Herman - The Todd Herman Show - YouTubeEpisode Links:For over 10 years every major LOTTERY jackpot across America was RIGGED by the one man hired to make sure it wasn't. UK Biobank Failures Expose the Permanent Cost of Sharing Genetic and Medical Records The promise of secure custodianship has failed 198 times in eleven months, and the volunteers who signed up in 2006 cannot take their DNA back. Federal law says new cars after 2026 must monitor drivers and shut down if the car disapproves. Your dashboard should not be judge, jury, and executioner. @RepScottPerry, @RepChipRoy offered an amendment to defund the automobile kill switch mandate. Here's our debate A YouTuber exposed that Flock Safety, the company with over 90,000 surveillance cameras across the US. is badly compromised. He discovered many of their cameras are live-streaming directly to the open internet with almost no security… Ford trucks are building a surveillance AND detainment system in the trucks you buy but NEVER really own. The Rockefeller University's US patent for remote modulation of cellular activities using ferritin nanoparticle compositions, which utilizes radio frequency waves to stimulate injected nanoparticles (like mRNA-based systems) inside the body, enabling remote control management of cellular function

In this Huberman Lab Essentials episode, my guest is Dr. Erich Jarvis, PhD, a professor and Head of the Laboratory of Neurogenetics of Language at Rockefeller University and an investigator at the Howard Hughes Medical Institute (HHMI). We discuss the brain circuits and genes underlying spoken language and why the ability to learn and produce vocalizations is extraordinarily rare in the animal kingdom. We also explore why song likely evolved before language, how gesture and movement share deep neural roots with speech, the neurobiology of stuttering, why childhood is the optimal window for language acquisition, and how physical movement — including dance — may help preserve speech and cognitive function across a lifetime. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Function: https://functionhealth.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (00:00:00) Speech & Language (00:00:23) Speech vs. Language; Brain Pathways for Communication (00:01:57) Gesture, Hand Movement & Speech Evolution (00:04:31) Sponsor: Function (00:05:59) Innate Vocalizations vs. Learned Speech (00:08:01) Evolution of Spoken Language; Neanderthals & Vocal Learning (00:09:29) Birdsong & Human Speech; Brain Circuit Parallels (00:13:22) Hummingbirds; Vocal Learning Species & Complex Traits (00:14:32) Critical Periods & Learning Your Native Song (00:16:50) Pidgin Language & Cultural-Genetic Convergence (00:18:36) Sponsor: AG1 (00:20:01) Genes Specialized in Speech Circuits (00:23:05) Critical Period for Language Learning; Multilingualism (00:25:17) Music, Emotion & Semantic vs. Affective Communication (00:28:14) Sponsor: Eight Sleep (00:29:49) Facial Expression & Speech Circuitry (00:31:07) Written Language & Neural Pathways (00:32:47) Stuttering; Basal Ganglia & Neurobiological Basis (00:35:03) Texting & Language Evolution (00:36:36) Tool: Movement, Dancing & Singing to Maintain Cognitive Health (00:38:43) Recap Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

In our April episode, gastroenterologist Dr. Preeti Mehta explained the connection between a healthy gut and a healthy mind. She also talked about the role stress plays in irritable bowel syndrome (IBS), a common digestive disorder that can often be managed with lifestyle changes. In this month's Key Note, Dr. Mehta discusses two other conditions that can be confused with IBS—and why getting the diagnosis right really matters. The Takeaway We want to hear from you! Please complete our survey: 1199SEIUBenefits.org/member-feedback. Drop us a line at our social media channels: Facebook // Instagram // YouTube. Find out where your health stands by making an appointment with your primary care physician. Don't have one? Find one at our Provider Directory: www.1199SEIUBenefits.org/find-a-provider. Visit the Healthy Living Resource Center for wellness tips, information and resources; www.1199SEIUBenefits.org/healthyliving. Get to know your numbers at www.1199SEIUBenefits.org/healthyhearts. Need support managing chronic conditions such as type 2 diabetes, hypertension or overweight? Learn about our partnerships: visit www.1199SEIUBenefits.org/the-choice-is-yours/ Browse healthy recipes and meal-prep tips at www.1199SEIUBenefits.org/food-as-medicine. Get inspired by fellow members through our Members' Voices series: www.1199SEIUBenefits.org/healthyliving/membervoices. Stop by our Benefits Channel to join webinars on building healthy meals, managing stress and more: www.1199SEIUBenefits.org/videos. Visit our  YouTube channel to view a wide collection of healthy living videos: www.youtube.com/@1199SEIUBenefitFunds/playlists. Sample our wellness classes to exercise body and mind: www.1199SEIUBenefits.org/wellnessevents   Guest Bio Preeti Mehta, MD, is a board-certified gastroenterologist and hepatologist with over 25 years of experience in digestive health care. She serves as Vice President of Digestive Disease Care, a multi-physician gastroenterology practice, and oversees two large Ambulatory Surgical Centers serving patients across Long Island and Queens. Dr. Mehta earned her Doctor of Medicine degree from the Icahn School of Medicine at Mount Sinai and completed her internship and residency in Internal Medicine at North Shore University Hospital in Manhasset, New York. She went on to complete a Research Fellowship in Hepatology at NewYork-Presbyterian Hospital, in affiliation with Weill Medical College of Cornell University and Rockefeller University. She also completed a Clinical Fellowship in Gastroenterology and Hepatology and an Advanced Endoscopy Fellowship in Endoscopic Ultrasound at the State University of New York. She is a member of the American College of Gastroenterology, the American Society for Gastrointestinal Endoscopy and the American Association for the Study of Liver Diseases.

This month, Health Is the Key does double duty as we spotlight National Stress Awareness Month and IBS Awareness Month. If you're wondering what stress has to do with irritable bowel syndrome and other digestive disorders, you'll be glad you tuned in. We are lucky to be joined by Dr. Preeti Mehta, a gastroenterologist and founder of the private practice Digestive Disease Care. Dr. Mehta explains the effect the brain has on the digestive system and vice-versa. She also shares practical lifestyle habits that can support long-term gut health.    The Takeaway  We want to hear from you! Please complete our survey: 1199SEIUBenefits.org/member-feedback. Drop us a line at our social media channels: Facebook // Instagram // YouTube. Find out where your health stands by making an appointment with your primary care physician. Don't have one? Find one at our Provider Directory: www.1199SEIUBenefits.org/find-a-provider.  Visit the Healthy Living Resource Center for wellness tips, information and resources; www.1199SEIUBenefits.org/healthyliving. Get to know your numbers at www.1199SEIUBenefits.org/healthyhearts.  Need support managing chronic conditions such as type 2 diabetes, hypertension or overweight? Learn about our partnerships: visit www.1199SEIUBenefits.org/the-choice-is-yours/ Browse healthy recipes and meal-prep tips at www.1199SEIUBenefits.org/food-as-medicine.  Get inspired by fellow members through our Members' Voices series: www.1199SEIUBenefits.org/healthyliving/membervoices.  Stop by our Benefits Channel to join webinars on building healthy meals, managing stress and more: www.1199SEIUBenefits.org/videos. Visit our  YouTube channel to view a wide collection of healthy living videos: www.youtube.com/@1199SEIUBenefitFunds/playlists. Sample our wellness classes to exercise body and mind: www.1199SEIUBenefits.org/wellnessevents.   Guest Bio  Preeti Mehta, MD, is a board-certified gastroenterologist and hepatologist with over 25 years of experience in digestive health care. She serves as Vice President of Digestive Disease Care, a multi-physician gastroenterology practice, and oversees two large Ambulatory Surgical Centers serving patients across Long Island and Queens.  Dr. Mehta earned her Doctor of Medicine degree from the Icahn School of Medicine at Mount Sinai and completed her internship and residency in Internal Medicine at North Shore University Hospital in Manhasset, New York. She went on to complete a Research Fellowship in Hepatology at NewYork-Presbyterian Hospital, in affiliation with Weill Medical College of Cornell University and Rockefeller University. She also completed a Clinical Fellowship in Gastroenterology and Hepatology and an Advanced Endoscopy Fellowship in Endoscopic Ultrasound at the State University of New York. She is a member of the American College of Gastroenterology, the American Society for Gastrointestinal Endoscopy and the American Association for the Study of Liver Diseases. 

Osteosarcoma Webinar Series: Ali Cihan, PhD, a research scholar at Memorial Sloan Kettering Cancer Center, will discuss his OutSmarting Osteosarcoma funded work on targeting EPHA2 with dual-armored CAR T cells for immunotherapy in pediatric osteosarcoma.Dr. Ali Cihan is a research scholar at Memorial Sloan Kettering Cancer Center, where he focuses on immunotherapy with a particular emphasis on advancing cellular therapies for pediatric solid tumors, including osteosarcoma. He received his Ph.D. from The Rockefeller University, where his research explored how chromosomal abnormalities and transcriptional dysregulation contribute to the development of high-risk pediatric leukemias. Motivated by the urgent need to improve outcomes for children with cancer, especially those facing limited treatment options, Dr. Cihan turned his focus to bridging laboratory discoveries and clinical application. His current work aims to develop immune-based therapeutic strategies that address the unique biological and clinical challenges of pediatric cancers.

Veja também em youtube.com/@45_graus Ana I. Domingos é neurocientista e Professora de Neurociência na Universidade de Oxford, onde investiga os mecanismos biológicos que regulam o metabolismo e o peso corporal, em particular o papel das redes nervosas simpáticas na queima de gordura e na obesidade. Formou-se em Matemática em Lisboa e Paris e fez o doutoramento na Rockefeller University, em Nova Iorque. O seu trabalho tem sido publicado em revistas científicas de topo como Nature e Cell e distinguido com várias bolsas internacionais, incluindo bolsas do Conselho Europeu de Investigação (ERC). É também membro da EMBO e editora-chefe do American Journal of Physiology – Endocrinology and Metabolism. _______________ Índice (1ª parte): Como é definida a obesidade? Limitações do IMC - Índice de Massa Corporal Países do mundo com mais obesidade. Causas genéticas. Leptina O que são calorias? É possível medir calorias que gastamos? Na dieta, é melhor perdermos peso lentamente? Leptina e infertilidade Porque países asiáticos têm baixa obesidade, mas alta incidência de diabetes tipo 2?See omnystudio.com/listener for privacy information.

Veja também em youtube.com/@45_graus Ana I. Domingos é neurocientista e Professora de Neurociência na Universidade de Oxford, onde investiga os mecanismos biológicos que regulam o metabolismo e o peso corporal, em particular o papel das redes nervosas simpáticas na queima de gordura e na obesidade. Formou-se em Matemática em Lisboa e Paris e fez o doutoramento na Rockefeller University, em Nova Iorque. O seu trabalho tem sido publicado em revistas científicas de topo como Nature e Cell e distinguido com várias bolsas internacionais, incluindo bolsas do Conselho Europeu de Investigação (ERC). É também membro da EMBO e editora-chefe do American Journal of Physiology – Endocrinology and Metabolism. _______________ Índice (2ª Parte): Porque tem aumentado a obesidade em todo o mundo? Sistema imunitário e obesidade. Imunometabolismo Papel do stress O que explica o nosso peso: genética vs ambiente Estudos com gémeos O caso dos labradores Ozempic: como funciona? Analogia entre obesidade e doenças psiquiátricas Até que ponto a biologia torna fazer dieta impossível para muitas pessoas?See omnystudio.com/listener for privacy information.

In this episode, Niall speaks with Dr. Kevin Tracey, a neurosurgeon, inventor, researcher, and author of “The Great Nerve”, who leads the Feinstein Institutes for Medical Research. Dr. Tracey's research has shown how the vagus nerve connects the brain and immune system, controlling inflammation in the body. His work has led to FDA-approved treatments for rheumatoid arthritis and may help with depression, PTSD, and other inflammatory conditions. In this conversation, they explore: — How the vagus nerve acts as a biological “brake” for inflammation — The potential of bioelectronic medicine to treat inflammatory diseases without immunosuppression — The story of Kelly Owens, whose life was transformed by vagus nerve stimulation — Why inflammation may underlie many modern diseases — The future of precision medicine using targeted nerve stimulation And more. You can learn more about Dr. Tracey's work through his book “The Great Nerve”, or at X at x.com/KevinJTraceyMD. — Kevin J. Tracey is president and CEO of, and the Karches Family Distinguished Chair in Medical Research at the Feinstein Institutes for Medical Research; professor of Molecular Medicine and Neurosurgery at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell; and Executive Vice President, Research, at Northwell Health. A leader in the scientific fields of inflammation and bioelectronic medicine, his contributions include discovery and molecular mapping of neural circuits controlling immunity. Dr. Tracey received his BS in chemistry, summa cum laude, Phi Beta Kappa, from Boston College in 1979, and his MD from Boston University in 1983. He trained in neurosurgery from 1983 to 1992 at the New York Hospital-Cornell University Medical Center and was a guest investigator at the Rockefeller University before moving in 1992 to the Feinstein Institutes. There he directs the Laboratory of Biomedical Science and was appointed president and CEO in 2005. An inventor of more than 120 United States patents and author of more than 400 scientific publications, he cofounded the Global Sepsis Alliance, a non-profit organization supporting the efforts of more than 1 million sepsis caregivers in over 70 countries. Dr. Tracey is the author of Fatal Sequence (Dana Press) and delivers lectures nationally and internationally on inflammation, sepsis, the neuroscience of immunity, and bioelectronic medicine. --- Interview Link: — Dr. Tracey's X: http://x.com/KevinJTraceyMD

Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut-brain signaling.Quick SummaryLearn how receptor internalization and neuropeptide GPCR signaling underlie the regulation of mosquito host-seeking and reproduction. Dr. Laura Duvall details the use of CRISPR-based assay development and fluorescence-driven phenotyping to connect molecular manipulation to whole-animal behavior. Her approach provides actionable insights for gpcr drug discovery and tools to dissect homologous pathways across model systems, with implications for pharmacology research targeting vector-borne disease transmission.Key TakeawaysNeuropeptide Y GPCRs modulate both host attraction and mating in Aedes aegypti.CRISPR and fluorescence assays enable precise behavioral phenotyping in vivo.GPCR-targeted compounds designed for humans can modulate mosquito receptors.NPY receptor expression in mosquito gut mirrors mammalian gut-brain signaling axes.Automated behavioral assays combined with machine learning sharpen data resolution and reduce human bias.Dr. GPCR Links & ResourcesExplore essential resources:Dr. GPCR EcosystemMembership & PricingWeekly NewsAdvance your research—discover the power of Dr. GPCR Premium.About the GuestDr. Laura Duvall earned her B.A. in Biochemistry and Biological Basis of Behavior from the University of Pennsylvania, followed by a PhD at Washington University in St. Louis, where she explored neuropeptide regulation of circadian behavior in Drosophila. Transitioning from fruit flies to mosquitoes, she pursued postdoctoral research at Rockefeller University with Leslie Vosshall, focusing on the molecular regulation of feeding and mating behaviors in Aedes aegypti. In 2019, she established her independent laboratory at Columbia University's Department of Biological Sciences and the Zuckerman Institute. Dr. Duvall's work is recognized by awards including the Beckman Young Investigator Award, Klingenstein-Simons Fellowship in Neuroscience, and the Pew Scholars Program, reflecting her drive to unravel the complex signaling mechanisms that govern mosquito and broader animal behavior.Guest on The WebLinkedIn: https://www.linkedin.com/in/laura-duvall-28a03485/Google Scholar: https://scholar.google.com/citations?user=Vk3KGSoAAAAJ&hl=enLab: https://www.duvalllab.com/

Episode #1688 : Dentistry Uncensored with Howard Farran, three industry leaders—Dr. Edward Rossomando, Dr. Gordon Christensen, and Chuck Cohen—come together for a wide-ranging discussion on the present and future impact of AI in dentistry. From clinical innovation to practice management and education, this roundtable explores how students, new grads, and experienced dentists can stay ahead of the curve as technology rapidly reshapes the profession.

Valentine's Day may be all about couples, but this week's episode celebrates heartbreak, breakups, and proudly being single as a Pringle.Part 1: Getting dumped is the push psychologist Jiawen Huang needs to step outside his comfort zone.Part 2: While completing her PhD in neuroscience, Leslie Sibener is determined to fix her relationship. Jiawen Huang obtained his PhD in Psychology from Columbia University, where he studied how prior knowledge provides a scaffold for prediction and memory. He grew up in China, and did his undergrad at University College London where he scanned people watching movies in fMRI scanner. In his free time, he can be found dancing salsa, practicing Spanish, and whittling wood carvings, all of which he started doing this past year.Leslie Sibener is a neuroscientist and science communicator based in New York City. She received degrees in Neuroscience and Creative Writing from Johns Hopkins University, and her PhD at Columbia University where she studied movement and motor learning. Now as a postdoctoral fellow at Rockefeller University, Leslie researches the mechanisms that allow specific memories to be stored for long term memory in the brain, while others are forgotten. She has always been passionate about sharing science outside of the lab. This has manifested in being the group leader the science writing group NeuWrite, a team member of Stories of WiN, and founder of Scientist on the Subway. Additionally, she has collaborated with a variety other groups, such as BioBus, Facts Machine Podcast, and the Dance Theatre of Harlem, to engage the public with science.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of The Rational Egoist, Michael Liebowitz speaks with Dr. Knut M. Wittkowski, a biostatistician and epidemiologist whose career has been grounded in data analysis, population-level disease dynamics, and research design.Dr. Wittkowski approaches the COVID pandemic not from politics or media narratives, but from statistical evidence and historical epidemiology. Drawing on decades of experience analysing infectious disease patterns, he challenges widely accepted assumptions about lockdowns, transmission dynamics, and public-health interventions. His focus throughout is on what the data actually show—rather than what policymakers, institutions, or commentators wished them to show.The discussion explores:How pandemics historically rise and fallThe difference between individual clinical outcomes and population-level effectsWhy certain interventions may have had unintended consequencesThe importance of distinguishing correlation from causation in public health policyHow fear and modelling assumptions can override empirical evidenceThis is a rigorous, analytical conversation that treats public health as a scientific discipline rather than a moral crusade—and asks hard questions about decision-making under uncertainty.About Dr. Knut M. WittkowskiDr. Knut M. Wittkowski holds a PhD in Biostatistics, with formal training in mathematical statistics and epidemiology in Germany. He served for roughly two decades as Head of Biostatistics, Epidemiology, and Research Design at Rockefeller University in New York.His work has focused on the statistical foundations of biomedical research, the interpretation of complex data sets, and the proper design of epidemiological studies. Throughout his career, Dr. Wittkowski has emphasised methodological rigour, empirical validation, and intellectual independence—particularly when scientific consensus becomes detached from data.About Michael Liebowitz – Host of The Rational EgoistMichael Liebowitz is the host of The Rational Egoist podcast, a philosopher, author, and political activist committed to the principles of reason, individualism, and rational self-interest. Deeply influenced by the philosophy of Ayn Rand, Michael uses his platform to challenge cultural dogma, expose moral contradictions, and defend the values that make human flourishing possible.His journey from a 25-year prison sentence to becoming a respected voice in the libertarian and Objectivist communities is a testament to the transformative power of philosophy. Today, Michael speaks, writes, and debates passionately in defence of individual rights and intellectual clarity.He is the co-author of two books examining the failures of the correctional system and the redemptive power of moral conviction:Down the Rabbit Hole: How the Culture of Corrections Encourages Crimehttps://www.amazon.com.au/Down-Rabbit-Hole-Corrections-Encourages/dp/197448064XView from a Cage: From Convict to Crusader for Libertyhttps://books2read.com/u/4jN6xjAbout Xenia Ioannou – Producer of The Rational EgoistXenia Ioannou is the producer of The Rational Egoist, responsible for overseeing the publishing, presentation, and promotion of each episode to ensure a consistent standard of clarity, professionalism, and intellectual rigour.She is the CEO of Alexa Real Estate, a property manager and entrepreneur, and serves on the Board of Directors of the Ayn Rand Centre Australia. Xenia also leads Capitalism and Coffee in Adelaide, creating a forum for thoughtful discussion on philosophy, culture, and independent thinking.Join Capitalism and Coffee here:https://www.meetup.com/adelaide-ayn-rand-meetup/Follow Xenia's essays on reason, independence, and purposeful living at her Substack:https://substack.com/@xeniaioannou?utm_source=user-menuBecause freedom is worth thinking about — and talking about.#TheRationalEgoist

Marta Paterlini"La pelle che pensa"Il tatto come linguaggio universale, tra filosofia, neuroscienze e tabù sociali.Codice Edizioniwww.codiceedizioni.itSottovalutato e dato per scontato, cos'è successo al tatto, l'atto più semplice e antico dell'umanità? Il tatto nasconde un mondo: è un linguaggio universale, un dialogo tra cervello e pelle, un atto di cura e una forma di resistenza in un'epoca in cui i corpi si allontanano. Centrale nei miti dell'Odissea e indagato dalla filosofia fin da Aristotele, il tatto è finalmente studiato dalle neuroscienze, che ne mostrano l'essenza: dalle carezze che alleviano il dolore nelle cure palliative alle fibre nervose che trasformano un massaggio in benessere; dalla fragilità di chi si chiude al contatto alla fame di pelle che genera disagio mentale. Nella società il tatto riflette visioni diverse del corpo, dell'identità e della cultura: la pelle sintetica della robotica, il tocco sociale, l'evoluzione dei saluti, le manipolazioni mediche, le politiche no-touch nelle scuole, fino alle ricerche sui canali Piezo del premio Nobel Ardem Patapoutian e alle fibre C-tattili del tocco affettivo. Sono questi i tasselli del mosaico che la neuroscienziata e divulgatrice Marta Paterlini ricompone in La pelle che pensa, mostrando come il tatto sia oggi sospeso tra tabù e necessità, paura del contatto e disperato bisogno di connessione. Perché toccare è curare, parlare, esistere.«In un mondo sempre più digitale, dove le relazioni spesso si sviluppano attraverso uno schermo, la pelle ci ricorda la magia del contatto diretto. Ogni abbraccio, ogni carezza, ogni stretta di mano è un ponte che ci avvicina, superando barriere culturali e linguistiche. Il tatto è uno dei primi canali attraverso cui esploriamo la realtà e instaura connessioni profonde tra gli individui. Ogni abbraccio sembra diverso perché tutti quelli che abbracciamo occupano spazio nel mondo in un modo diverso». Marta PaterliniMarta PaterliniNeurobiologa e giornalista scientifica freelance. Ha lavorato presso il Laboratory of Molecular Biology di Cambridge, in Inghilterra, e alla Rockefeller University di New York. Attualmente è senior scientist presso il Karolinska Institutet di Stoccolma, dove vive. Collabora con “Science”, “Nature” e “The Lancet”.Diventa un supporter di questo podcast: https://www.spreaker.com/podcast/il-posto-delle-parole--1487855/support.IL POSTO DELLE PAROLEascoltare fa pensarehttps://ilpostodelleparole.it/

If you've heard the hammering of a woodpecker in the woods, you might have wondered how the birds can be so forceful. What does it take to whack your head against a tree repeatedly, hard enough to drill a hole? A team of researchers wondered that too and set out to investigate, by putting tiny muscle monitors on eight downy woodpeckers and recording them with high-speed video as they pecked away in the lab.Integrative organismal biologist Nick Antonson, co-author of a report on the work, joins Host Flora Lichtmen to peck away at the mystery.Plus, you can take two ant eggs with the exact same genes, and one can grow up to be a queen, the other a worker. Neuroscientist and evolutionary biologist Daniel Kronauer joins Flora to share recent research into how an ant becomes a queen.Guests: Dr. Nick Antonson is an NSF postdoctoral research fellow in the department of ecology, evolution, and organismal biology at Brown University.Dr. Daniel Kronauer is the Stanley S. and Sydney R. Shuman Professor in the Laboratory of Social Evolution and Behavior at The Rockefeller University in New York.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Send us a textDr. Julia Moore Vogel, PhD, MBA is Assistant Professor and Senior Program Director at The Scripps Research Institute ( https://www.scripps.edu/science-and-medicine/translational-institute/about/people/julia-moore-vogel/ ) where she is responsible for managing a broad portfolio of patient-centric health research studies, including The Long COVID Treatment Trial ( https://longcovid.scripps.edu/locitt-t/ ), a fully remote, randomized, placebo-controlled clinical trial targeting individuals with long COVID, testing whether the drug Tirzepatide can reduce or alleviate symptoms of long COVID. Prior to this current role, Dr. Vogel managed The Participant Center (TPC) for the NIH All of Us Research Program ( https://www.scripps.edu/science-and-medicine/translational-institute/translational-research/precision-medicine/index.html ) which was charged with recruiting and retaining 350,000 individuals that represent the diversity of the United States. TPC aims to make it possible for interested individuals anywhere in the US to become active participants, for example by collaborating with numerous outreach partners to raise awareness, collecting biosamples nationwide, returning participants' results and developing self-guided workflows that enable participants to join whenever is convenient for them. Prior to joining the Scripps Research Translational Institute, Dr. Vogel created, proposed, fundraised for, and implemented research and clinical genomics initiatives at the New York Genome Center and The Rockefeller University. She oversaw the proposal and execution of grants, including a $44M NIH Center for Common Disease Genomics in collaboration with over 20 scientific contributors across seven institutions. She also managed corporate partnerships, including one with IBM that assessed the relative value of several genomic assays for cancer patients. Dr. Vogel has a BS in Mathematics from Rensselaer Polytechnic Institute, a  PhD in Computational Biology and Medicine from Cornell and an MBA from Cornell. Important Episode Links - Nature Reviews Microbiology - Long COVID: major findings, mechanisms and recommendations -https://www.nature.com/articles/s41579-022-00846-2npj Digital Medicine - Long-term changes in wearable sensor data in people with and without Long Covid -https://www.nature.com/articles/s41746-024-01238-xMayo Clinic Proceedings: Innovations, Quality & Outcomes - A Randomized Trial of At-Home COVID-19 Tests, Telemedicine, and Rapid Prescription Delivery for Immunocompromised Individuals -https://www.sciencedirect.com/science/article/pii/S2542454825000384#JuliaMooreVogel #ScrippsResearchInstitute #EricTopol #LongCovidTreatmentTrial #AllOfUsResearchProgram #ComputationalBiology #NewYorkGenomeCenter #MyalgicEncephalomyelitis #ChronicFatigueSyndrome #ImmuneDysregulation #MicrovascularInjury #MetabolicDysfunction #Neuroinflammation #AutonomicDysfunction #Tirzepatide #Zepbound #RemoteClinicalTrial #Cornell #RockefellerUniversity#MemorialSloanKetteringCancerCenter #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show

Auto-generated transcript: We come to the last of the principles. He says reputation outlasts riches. John D Rockefeller, he gave away 500 million in charities. He built the University of Chicago and Rockefeller University. He treated his people well with respect. And he always says money disappears, reputation echoes through generations. And your legacy is… Continue reading Rockefeller’s advice – 9

In this episode of Better Thinking, Nesh Nikolic speaks with Professor Zoltán Sarnyai about his recent randomized controlled trial on ketogenic metabolic therapy for serious mental illness and the broader implications of this emerging field for the future of psychiatric treatment.Professor Zoltán Sarnyai, Director of the Margaret Roderick Centre for Mental health Research at James Cook University, is a medically trained neuroscientist with an internationally recognised expertise in the neurobiology of stress and mental health disorders. Before moving to Australia, he was University Lecturer in the Department of Pharmacology, University of Cambridge and a Fellow of Pembroke College, where he was Director of Studies for Medicine. He trained at McLean Hospital at Harvard Medical School and at The Rockefeller University, supported by the DuPont-Warren Award and a NARSAD Young Investigator Award, respectively. His group described the role of stress neuropeptides oxytocin and corticotropin-releasing factor in addiction, for which he was awarded the Richter Prize by the International Society of Psychoneuroendocrinology. More recently, he discovered the efficacy of ketogenic metabolic therapy in preclinical models of schizophrenia and is currently conducting the world's first randomised controlled clinical trial to investigate this in clinical populations. Zoltán was appointed Lady Davis Visiting Professor at Technion-Israel Institute of Technology to study the neuro- metabolic aspects of schizophrenia. Zoltan has published over 150 original research papers, reviews and book chapters, his works have been cited over 10,000 time, with an H index of 50. He is Associate Editor for Nutritional Neuroscience and Frontiers in Neuroscience, and editorial board member of Nutritional Psychiatry and Stress.

This week, we zoom out to the broader intellectual themes that shaped Decouple's origins five years ago. I'm joined by Jesse Ausubel, a visionary in sustainability and biodiversity research and the Director of the Program for the Human Environment at The Rockefeller University in New York City. In his long career, Ausubel pioneered the modern study of decarbonization and dematerialization in the late 1980s and early 1990s. He helped organize the first UN World Climate Conference in 1979 and spent the 1980s at the National Academies formulating U.S. and global climate research programs. In parallel, he has led major biodiversity initiatives including the decade-long Census of Marine Life, the DNA Barcode of Life project, and continues surveying ocean biodiversity using environmental DNA.In this conversation, Ausubel shows how the simple framework of logistic S-curves can illuminate fundamental trends across complex systems, including energy systems. Through this lens, we discuss the “environmental trifecta” of land-sparing, decarbonization, and dematerialization, and we explore whether apparent counter-trends challenge Ausubel's framework. Suffusing the interview is Ausubel's belief in the wisdom of long-term thinking and objectivity: simple, insightful frameworks are a starting point for admitting much-needed complexity into our worldviews. Join us in this rare examination of the mental models that claim to predict our environmental future.

Dr Edward Rossomando DDS, PhD is presently an emeritus professor at the University of Connecticut School of Dental Medicine. Dr Rossomando earned a DDS from the University of Pennsylvania and a PhD from the Rockefeller University. He is the author of more than 200 research papers and two books. He is the founder and emeritus president of the Center for Research and Education in Technology and the founder of the dental discipline Biodontics. He is also the Editor in Chief of the e-journal Dental Hypotheses. He has started several companies around the patent to recover biochemicals from the gingival crevice. He has received several awards, including the Alumni award of Merit from the University of Pennsylvania.    During his nearly 50 year career he has been an educator, scientist, inventor, and entrepreneur, but he would like to be remembered as a loving father of two outstanding daughters and husband of the most wonderful wife, Nina.   Join Dentaltown.com today for more great dental content and discuss great dentistry with great dentists!

FEATURED GUESTS: Stefan OlivaStefan is the co-founder of FrameShare, a digital art therapy platform designed to expand access to creative mental health care. With a background in mission-driven tech entrepreneurship, Stefan helped launch Yale University's first student-led impact investment fund and was an early team member at Gro Intelligence, a global agriculture and climate platform founded in Nairobi, Kenya. His work sits at the intersection of technology and equity—shaped by his lifelong relationship to art, community care, and systems change.Dr. Stephan Meyer zum Alten BorglohStephan is FrameShare's Chief Technology Officer. He holds a PhD in neuroscience from the Max Planck Institute and completed his postdoctoral research at Rockefeller University, where he transitioned from laboratory work to developing research and clinical applications. After his postdoc, Stephan helped multiple startups shape their data strategies and build innovative products, with experience spanning clinical technologies and climate tech.LISTEN & LEARN:What is Frameshare?How accessible is Frameshare?What features does Frameshare currently offer that meet the needs of art therapists? What are the plans for the future of Frameshare?RESOURCES MENTIONED ON THE SHOW:Website Before October 2025 https://www.frame-share.org After October 2025https://www.frameshare.orgLinkedIn: https://www.linkedin.com/company/frame-share/about/Email Stefan Oliva at Stefan@frameshare.org Email Dr. Stephan Meyer zum Alten Borgloh at Stephan@frameshare.org

Kevin J. Tracey is president and CEO and the Karches Family Distinguished Chair in Medical Research at the Feinstein Institutes for Medical Research; professor of Molecular Medicine and Neurosurgery at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell; and Executive Vice President, Research, at Northwell Health. A leader in the scientific fields of inflammation and bioelectronic medicine, his contributions include discovery and molecular mapping of neural circuits controlling immunity. Dr. Tracey received his BS in chemistry, summa cum laude, Phi Beta Kappa, from Boston College in 1979, and his MD from Boston University in 1983. He trained in neurosurgery from 1983 to 1992 at the New York Hospital-Cornell University Medical Center and was a guest investigator at the Rockefeller University before moving in 1992 to the Feinstein Institutes. There he directs the Laboratory of Biomedical Science and was appointed president and CEO in 2005.An inventor of more than 120 United States patents and author of more than 400 scientific publications, he cofounded the Global Sepsis Alliance, a non-profit organization supporting the efforts of more than 1 million sepsis caregivers in over 70 countries. Dr. Tracey is the author of Fatal Sequence (Dana Press) and delivers lectures nationally and internationally on inflammation, sepsis, the neuroscience of immunity, and bioelectronic medicine.

Vidcast:  https://www.instagram.com/p/DN05tuXXix_/In the search for ever more effective and selective ways to fight cancer, researchers at Columbia University's School of Engineering and Applied Science in collaboration with those at Rockefeller University have bioengineered a bacterium that selectively ferries a cell-killing virus into cancer cells.  They call this system CAPPSID which stands for Coordinated Activity of Prokaryote and Picornavirus for Safe Intracellular Delivery.The prokaryote in question is a salmonella species and the picornavirus is the Senecavirus.  This salmonella selectively invades tumor cells and delivers not only the virus but also an enzyme necessary to activate the virus once inside the tumor cell.  This permits the virus to slip past the immune system, sneak into cancers, and attack tumor cells from the inside.Using a preclinical mouse model, the bacteria successfully homed in on their tumors, delivered the virus, and then self-destructed to release it. To prevent the virus from killing normal mouse cells, the virus can only proliferate in the presence of the protease enzyme supplied by the cancer-homing bacterium.This is the first example of directly engineered cooperation between bacteria and viruses with the goal of cancer eradication.  , and it may open the door to a new class of living medicines for solid tumors. Clinical studies are now in the planning stages making it possible that this technology could be added to existing cancer therapy…..someday soonhttps://www.nature.com/articles/s41551-025-01476-8#cancer #bacteria #viruses #salmonella #picornavirus #trojanhorse

Send us a textIn this inspiring episode, Rino Rappuoli, PhD, a true pioneer in modern vaccinology and recipient of the 2025 Maxwell Finland Award for Scientific Achievement, joins Marla Dalton, CAE, and William Schaffner, MD, to explore his groundbreaking work in vaccinology. From his early days in Siena, Italy, to leading the development of life‑saving vaccines against meningitis, pertussis, and influenza, Rappuoli has transformed how vaccines are developed. He shares insights on mentorship, the origins of reverse vaccinology, climate change, and the future role of artificial intelligence in disease prevention. Tune in for a powerful conversation about science, innovation, and the unwavering drive to protect public health.  Show NotesRappuoli is scientific director of the Biotecnopolo di Siena Foundation, Italy, honorary professor of Vaccinology at Imperial College, London, and senior professor of molecular biology at the University of Siena. He was previously head of external R&D and chief scientist at GSK Vaccines and founded the GSK Vaccines Institute for Global Health. He earned his PhD in biological sciences at the University of Siena, Italy, and was visiting scientist at Rockefeller University and Harvard Medical School. An elected member of the National Academy of Sciences, he was awarded the Albert B Sabin Gold Medal in 2009. He is currently president of the International Union of Microbiological Societies. Rappuoli is among the world's scientific leaders dedicated to the sustainability of global health and his work has contributed significantly to improving the quality of human life. Follow NFID on social media

Synopsis: What happens when a world-class scientist and a philanthropic legacy collide with one of medicine's greatest challenges? Dr. Howard Fillit and Mark Roithmayr of the Alzheimer's Drug Discovery Foundation (ADDF) join host Alok Tayi for an inspiring conversation on bold science, visionary funding models, and the future of Alzheimer's research. From treating Estée Lauder in the 1990s to building a $100M venture philanthropy engine, they trace ADDF's evolution into a global leader in high-risk, high-reward drug development. The discussion covers the rise of biomarkers and digital diagnostics, the foundation's partnerships with visionaries like Bill Gates and Jeff Bezos, and how ADDF's venture philanthropy approach bridges the “valley of death” in biotech. They also dive into global regulatory challenges, the economic urgency of Alzheimer's, and why the future lies in prevention, precision medicine, and a patient-first mindset. This episode is a masterclass in scientific grit, ecosystem thinking, and turning urgency into progress. Biography: Howard Fillit, MD Founding Executive Director and Chief Science Officer of the Alzheimer's Drug Discovery Foundation Howard Fillit, MD, is a geriatrician, neuroscientist, and innovative philanthropy executive, who has led the Alzheimer's Drug Discovery Foundation (ADDF) since its founding. Dr. Fillit has held faculty positions at The Rockefeller University, the SUNY-Stony Brook School of Medicine and the Cornell University School of Medicine. In 1987, he joined the Mount Sinai School of Medicine, where he is a clinical professor of geriatric medicine and palliative care, medicine and neuroscience. Dr. Fillit also maintains a limited private practice in consultative geriatric medicine with a focus on Alzheimer's disease and related dementias. He has authored or co-authored more than 300 publications and is the senior editor of Brocklehurst's Textbook of Geriatric Medicine and Gerontology. Dr. Fillit is the recipient of many awards and honors including the Rita Hayworth Award from the Alzheimer's Association. Mark Roithmayr Chief Executive Officer Mark Roithmayr is an admired nonprofit leader with four decades of experience in both start-ups and mature organizations. As CEO of the ADDF, he is responsible for steering the Foundation's overall strategy, focus, and business operations. Since joining the ADDF in 2017, the organization has transformed dramatically in impact, scale, presence, and brand. Under his leadership, the ADDF's revenue has increased five-fold from $17M to over $90M, and mission-related investing has grown over 100%. He works closely with Dr. Fillit, executive leadership, and the board to advance the ADDF's mission of accelerating the discovery of drugs to prevent, treat, and cure Alzheimer's disease and related dementias. His key accomplishments include securing donations from Bill Gates, Jeff Bezos, and MacKenzie Scott, and a 10-figure gift from the Lauder family to cover ADDF's overhead for the next 20 years.

V Bratislave študovala fyziku a chémiu na vysokej škole. V júli 1968 odišla na stáž do Frankfurtu a v roku 1968 emigrovala s rodinou do Ameriky. Pokračovala v štúdiu na Columbia University odbor fyzika, neskôr biológia. Postdoktorandské štúdium absolvovala v Oxforde a druhú polovicu v The Rockefeller University v New Yorku. Výskumu sa venovala do roku 2003. Na dôchodku sa venuje písaniu komentárov o konferenciách alebo knižným recenziám do The New York Academy of Sciences. Od roku 2010 sa stala predsedníčkou Spoločnosti pre históriu československých Židov.

Getting outdoors into the sun is healthy, but when is it too much and are we putting our skin at risk if we don't protect it? Today's episode I dive into skin cancer with skin cancer surgeon and dermatologist Dr. Ellen Marmur. We cover: Different types of skin cancers and what to look out for How to screen for skin cancer If you need surgery and if so, how best to remove skin cancers What those white freckles on your legs really mean Where skin cancers show up most for women in midlife Photobiomodulation – light therapy can be used for skin cancer treatment and prevention Lasers How best to protect your skin Is sunscreen toxic and what to look out for when buying, plus what she uses The best and worst times to spend time outdoors Should we really be skipping the sunglasses to set our circadian rhythm? The coolest light device for skin treatment, even cancer, and protection   Dr. Ellen Marmur is one of New York City's most respected dermatologists, known for her unique combination of expertise in skin cancer surgery and cosmetic dermatology. After eight years as the first woman Chief of Dermatologic Surgery at Mount Sinai Medical Center, Dr. Ellen founded Marmur Medical, where she has spent the past decade pioneering advanced treatments in skin cancer, Mohs surgery, reconstructive surgery, women's health dermatology, and aesthetic procedures. Dr. Marmur has done pioneering research in green LED light therapy, in collaboration with Rockefeller University. Dr. Marmur is a full Clinical Professor of Dermatology at Mount Sinai Medical Center, where she trains the next generation of dermatologists.  Get 15% off the MMSphere and other products on the Marmur Medical website and MMSkincare.com with code ZORA or this link https://mmskincare.com/zorab Website: https://www.marmurmedical.com Website: https://mmskincare.com/ Contact Dr. Ellen Marmur Instagram: https://www.instagram.com/dr_ellen_marmur Instagram: https://instagram.com/mmskincare  TikTok: https://tiktok.com/@dr.ellenmarmur  TikTok: https://tiktok.com/@mmskincaregenius  TikTok: https://tiktok.com/@marmurmedical   Give thanks to our sponsors: Qualia senolytics and brain supplements. 15% off with code ZORA here.  Try BEAM minerals at 20% off with code ZORA here. Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Get Mitopure Urolithin A by Timeline. 10% discount with code ZORA at  Get Magnesium Breakthrough by Bioptimizers. 10% discount with code HACKMYAGE at  Try OneSkin skincare with code ZORA for 15% off https://shareasale.com/r.cfm?b=2685556&u=4476154&m=102446&urllink=&afftrack= Join ⁠⁠⁠Biohacking Menopause⁠⁠⁠ before May 1, 2025 to win a bottle of Accelerated Health iodine and Essential Amino Acids! 10% off with code ZORA at AcceleratedHealth.com   Join the Hack My Age community on: Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠     Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠  Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠   

In this episode of the Epigenetics Podcast, we talked with Viviana Risca from Rockefeller University about her work on RICC-Seq and how it's used to probe DNA-DNA contacts in intact or fixed cells using ionizing radiation. This Interview covers Dr. Viviana Risca's cutting-edge methodologies, such as RICC-seq, which enables high-resolution analysis of chromatin structures without traditional cross-linking biases. We engage in a detailed discussion about how different techniques, such as RICC-seq and Micro-C, complement each other to provide robust insights into nucleosome interactions and chromatin dynamics. Dr. Risca articulates the challenges and innovations within her lab as it navigates through the complexities of chromatin mapping. The episode takes an exciting turn toward traversing the landscape of her future research directions, particularly studying the role of linker histones and other chromatin architectural proteins in regulating gene expression. Dr. Risca emphasizes the importance of understanding chromatin's mechanical properties and how these influence cellular processes like transcriptional regulation, DNA replication, and cellular responses to damage. We also explore her collaborative work that bridges the gap between basic research and clinical applications, particularly in cancer therapy. Dr. Risca shares insights into her investigations into how chromatin dynamics change during cell cycle arrest and their implications for cancer therapy resistance. Our discussion culminates in her reflections on the definition of epigenetics, framing it as the exploration of how cellular mechanisms encode and process information.   References Risca VI, Denny SK, Straight AF, Greenleaf WJ. Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping. Nature. 2017 Jan 12;541(7636):237-241. doi: 10.1038/nature20781. Epub 2016 Dec 26. PMID: 28024297; PMCID: PMC5526328. Soroczynski J, Anderson LJ, Yeung JL, Rendleman JM, Oren DA, Konishi HA, Risca VI. OpenTn5: Open-Source Resource for Robust and Scalable Tn5 Transposase Purification and Characterization. bioRxiv [Preprint]. 2024 Jul 13:2024.07.11.602973. doi: 10.1101/2024.07.11.602973. PMID: 39026714; PMCID: PMC11257509. Prescott, N. A., Biaco, T., Mansisidor, A., Bram, Y., Rendleman, J., Faulkner, S. C., Lemmon, A. A., Lim, C., Tiersky, R., Salataj, E., Garcia-Martinez, L., Borges, R. L., Morey, L., Hamard, P.-J., Koche, R. P., Risca, V. I., Schwartz, R. E., & David, Y. (2025). A nucleosome switch primes hepatitis B virus infection. Cell, S0092867425001023. https://doi.org/10.1016/j.cell.2025.01.033   Related Episodes Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden) Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman) Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

“People always say, ‘Well, if I could only do one art form, what would it be?' And I always say dance.” —Susan Magsamen In our podcast miniseries Music and Health, we're exploring how music impacts our minds, bodies, and communities. In this installment, we're learning about the power of dance. Host J. D. Talasek is joined by David Leventhal and ConstantinaTheofanopoulou. Both began their careers as dancers and use dance to inform their current work. Leventhal is a program director and one of the founding teachers of Dance for PD, a program that offers people with Parkinson's disease research-backed dance classes. Theofanopoulou is a research assistant professor at Rockefeller University. Her research focuses on understanding the neuroscience of complex sensory motor behaviors. They discuss how dance is helping patients regain movement abilities, and what neuroscience research says about dance as a form of healing. This series is produced in collaboration with Susan Magsamen and Leonardo journal.Resources:  Listen to the first episode of the mini-series, Music and Health: The Creative Arts and Healing, featuring Renée Fleming and Susan Magsamen.  Visit the Dance for PD website to learn more about the program, and find classes in your area or virtually.  Learn more about Constantina Theofanopoulou's research by visiting her website. 

We're experimenting and would love to hear from you!In this episode of 'Discover Daily', we begin with the unexpected shutdown of Humane's AI Pin. The much-discussed wearable device's discontinuation and subsequent $116 million acquisition by HP marks a significant shift in the wearable AI landscape, highlighting the challenges of introducing new device categories in today's competitive market.We also delve into the launch of Protector, an innovative app revolutionizing personal security in major US cities. This "Uber for armed guards" service offers on-demand access to professional security details and motorcades, bringing high-end protection services to a broader audience through a user-friendly platform in Los Angeles and New York City.The episode's main focus examines a fascinating breakthrough in human evolution research: the NOVA1 gene's role in speech development. Scientists at Rockefeller University have identified this crucial protein variant, present in virtually all modern humans, as a potential key to understanding how we developed our unique capacity for complex speech. Through groundbreaking experiments with genetically modified mice, researchers have demonstrated NOVA1's significant impact on vocalization patterns, opening new possibilities for treating communication disorders and understanding human evolution.From Perplexity's Discover Feed: https://www.perplexity.ai/page/humane-shuts-down-ai-pin-QYaGHA_mRQaNJYpvrVc3.whttps://www.perplexity.ai/page/uber-for-armed-guards-climbs-a-3vMrFSDqQ5ududobBxbgzAhttps://www.perplexity.ai/page/human-speech-gene-identified-lk71mFheSMqALlOPuwVOgQ**Introducing Perplexity Deep Research:**https://www.perplexity.ai/hub/blog/introducing-perplexity-deep-research Perplexity is the fastest and most powerful way to search the web. Perplexity crawls the web and curates the most relevant and up-to-date sources (from academic papers to Reddit threads) to create the perfect response to any question or topic you're interested in. Take the world's knowledge with you anywhere. Available on iOS and Android Join our growing Discord community for the latest updates and exclusive content. Follow us on: Instagram Threads X (Twitter) YouTube Linkedin

Precision medicine is a medical approach that considers a patient's genes, environment, and lifestyle. In the realm of Alzheimer's disease, experts are pushing for using this approach to improve diagnosis, treatment, and our understanding of the condition. But what does precision medicine for patients with Alzheimer's disease and other dementias look like? The Alzheimer's Drug Discovery Foundation (ADDF)'s Dr. Howard Fillit joins Being Patient Live Talks to discuss precision medicine and its potential in Alzheimer's diagnosis and care. Fillit is an award-winning geriatrician, neuroscientist, and innovative philanthropy executive who has led the ADDF since its founding. He has authored or co-authored over 300 publications and is the senior editor of Brocklehurst's Textbook of Geriatric Medicine and Gerontology. He has held faculty positions at Rockefeller University, the SUNY-Stony Brook School of Medicine, and the Cornell University School of Medicine. Fillit also maintains a limited private practice in consultative geriatric medicine focusing on Alzheimer's disease and related dementias.

In the fifth Season of the National Institute of Neurological Disorders and Stroke's Building Up the Nerve podcast, we help you strengthen your science communication skills with tools and advice to use throughout your career. We know that navigating your career can be daunting, but we're here to help—it's our job!In the eighth episode of the season, we talk about Establishing Your Professional Identity, focusing on tips for defining who you are in your career, and developing skills and strategies to create and communicate who you are, or what your “brand” is, in your field and in the public.Featuring Thiago Arzua, PhD, Postdoctoral Fellow at Columbia University's Zuckerman Institute; Carmen Maldonado-Vlaar, PhD, Professor at University of Puerto Rico-Río Piedras Campus; and Erich Jarvis, PhD, Professor at Rockefeller University and Investigator at Howard Hughes Medical Institute.ResourcesPicture a Scientist: https://www.pictureascientist.com/ Black in Neuro: https://blackinneuro.com/ Ciencia Puerto Rico: https://www.cienciapr.org/ NIH Blueprint and BRAIN Initiative® ENDURE R25 Program: https://neuroscienceblueprint.nih.gov/training/endure-undergraduate-education NEURO-ID Program: https://neuroid.uprrp.edu/NeuroBoricuas at UPR Cayey: https://neuroboricuasuprcayey.wordpress.com/ Transcript available at http://ninds.buzzsprout.com/.

Piezo touch and pressure-sensing ion channels are showing up everywhere as the explanation for physiologic phenomena, both at the macro and micro levels. Ardem Patapoutian, my friend and colleague at Scripps Research, discovered these receptors back in 2010 and was awarded the Nobel Prize in 2021 for his work. As you'll see/hear from our conversation, the field has exploded. And you'll get to know Ardem, who is such a fun, charismatic, and down-to-earth person. He also recently got a unique tattoo (videos below) and I wonder (unlikely) if any other Nobel laureates have one related to their discovery?!Below is a video clip from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The current one is here. If you like the YouTube format, please subscribe! The audios are also available on Apple and Spotify.Transcript with links to audioEric Topol (00:07):Well, hello. It's Eric Topol with Ground Truths, and I've really got a special guest today. The first time for the podcast, I've been able to interview a colleague and faculty at Scripps Research, Ardem Patapoutian, who just by the way happens to be the 2021 Nobel Laureate in Physiology or Medicine. So welcome, Ardem. It's so wonderful to have you.Ardem Patapoutian (00:30):Thanks so much, Eric. Looking forward to chatting with you.Eric Topol (00:34):Well, this has been interesting because although I've known you for several years, I didn't research you. I mean, I had to learn about more than I even do. And of course, one of the great sources of that is on the Nobel Prize website where you tell your whole story. It is quite a story and not to review all of it, but I wanted to go back just before you made the call to move to Los Angeles from Beirut, Lebanon and with the scare that you went through at that time, it seemed like that was just extraordinary that you had to live through that.Ardem Patapoutian (01:11):Yeah, so I am of Armenian origin, but I was born in Lebanon and born in 1967, so I was eight years old when the civil war started. So it's a kind of bizarre childhood in the sense that with all the bombs and fighting in Lebanon. So it was tough childhood to have, but it was never personal. It was bombs and such. And so, the event you're talking about is, I happened to be kidnapped while crossing East to West Beirut. They only held me for four or five hours at first asking me questions to see who I am, but I think they pretty soon figured out that I was not a dangerous guy and they ended up letting me go. But before that, that incident really had a huge impact on me so that by the time I got home, I literally said, I'm out of here. I'm going to find a way to leave the country. And so, that's what, very quickly within a few months I packed and came to United States.Eric Topol (02:19):And how did you pick LA to be your destination?Ardem Patapoutian (02:22):Being from the Armenian community, there's a lot of Armenians in Los Angeles. My cousins already had moved there. They also grew up in Lebanon. And my brother, who's a few years older than me, got admitted to USC graduate school in engineering. So he was going to be there. So it made a lot of sense.Eric Topol (02:44):Oh yeah.Ardem Patapoutian (02:45):Unlike him, I came with no school or job prospects because it happened so fast that I kind of just left. One year I was at American University of Beirut for one year, but then just left and came here. So worked for a year in various jobs and then started going back to school to UCLA.Eric Topol (03:07):Yeah, I saw how there was about a year where you were delivering pizzas and before you got into UCLA, and that must have been an interesting off year, if you will. Well, the story of course, just to fast forward, you did your baccalaureate at UCLA, your PhD at Caltech, postdoc at UCSF, and then you came to Scripps Research 24 years ago along with Pete Schultz, and it's been quite an amazing run that you've had. Now, before we get into PIEZO receptors, the background, maybe you could help me understand, the precursor work seems to be all related to the transient receptor potential (TRP) series, also ion channels. They were of course related to whether it was heat and temperature or somatosensory. How do these channels compare to the ones that you discovered years later?Background on these Ion ChannelsArdem Patapoutian (04:09):Yeah, so the somatosensory neurons that innervate your fingertips and everywhere else in your body, their main job is to sense temperature and pressure. And this is very different than any other neuron or any other cell. So when you touch a hot stove that's burning hot, you need to know about that immediately within milliseconds or something cold. So the opposite side of it is pressure sensing, and it also comes in light touch, which is pleasant or a hammer hitting your finger, which is unpleasant. But all of these have the same characteristic anyway, that is your body has learned at the molecular level to translate a physical stimulus such as temperature and pressure into an electrical signal that neurons use to communicate with each other. But this idea of how you translate physical stimuli into chemical or electrical signal has been a long open question because as you know, most of our cells communicate by chemicals, whether that's hormones or small molecules, we know how that works, receptor bind to ligand, confirmational change and you get a kinase activation and that's enough. But here, how do you sense pressure? How do you sense temperature? It was just, there wasn't much known about that. And that's why our earlier work on TRP channels, which were temperature sensors came before the pressure. And so, they're very related in that sense.Eric Topol (05:52):The structure of these, if you were to look at them, do they look pretty similar? What the TRP as you say, and what you did back in the 2010 Science paper, which we'll link to, of course the classic paper where you describe PIEZO1 and PIEZO2, but if you were to look at this structures, would they look pretty similar?Ardem Patapoutian (06:14):No, that's a good question. And they absolutely don't. That's why finding these receptors were so hard. So if you go back to other sensory receptors, vision rhodopsin G-protein coupled receptor (GPCRs), larger G-protein coupled receptor look the same. So for example, when it was identified by chemically, that smell also works through G-protein coupled receptor. Richard Axel and Linda Buck, who also won the Nobel Prize, found those receptors by homology to visual GPCRs. The ion channels other than the fact that they crossed the membrane a few times or more, they have nothing else in common. If you looked at their structure, you can't even immediately tell they're ion channels. So you couldn't find these by structural homology or sequence homology. So you had to do something else. And usually that means functional screens and et cetera.Eric Topol (07:09):Well, yeah, and I'm in touch with the screening. We'll get to that and how you dig these up and find them. But the somatosensory ones are really interesting because I don't think a lot of people realize that when you have wasabi or you have Listerine mouthwash and feel the burn and that these are all mediated through these channels, right?Ardem Patapoutian (07:35):Yeah. So there's this whole field of chemesthesis, which means senses in your mouth, for example, that are not explained by taste transduction and olfactory. And these are actually by the same somatosensory neurons that help you sense temperature and pressure. And some of these receptors are the same. Their evolution has taken over and used them for many different things. The prime example of this is the capsaicin receptor that David Julius my co-laureate identified, which is also heat receptors. So all languages describe chili peppers as hot, and that's not a coincidence. It actually activates heat activated channel, and that's why we think of it as hot. And so, the same goes to another one of these TRP channels that you mentioned, which is TRPA1, and this one is also activated, but a lot of spicy foods other than the chili pepper active ingredient includes what's in garlic and onions and everything that has this burning sensation and chemicals of this and wasabi and chemicals of this are used in over the counter products like Listerine that cause that burning sensation.Eric Topol (08:54):So when you're chopping onions and it makes you cry, is that all part of it as well?Ardem Patapoutian (08:59):That's all TRPA1, yeah.The Discovery, A Test of PerseveranceEric Topol (09:01):It's wild. Now, this was the groundwork. There were these heat temperature and somatic sensory, and then you were starting to wonder what about touch, what about out pressure and proprioception. And so, you went on a hunt, and it's actually kind of an incredible story about how you were able to find out of these cells that you had, screening hundreds or I guess you got to 72 different small interfering RNA blocking that you finally found the one. Is that right?Ardem Patapoutian (09:37):That's right. So in retrospect, looking back at it, I think there's such an interesting scientific message there. And so, many of us were looking for this touch pressure sensors and we were all looking in the DRG sensory neurons that are complicated heterogeneous, they don't divide. It's not easy to do a screen on them. And ultimately after a lot of failures, what worked for us is to take a step back and ask a much more simpler question. And that was, can we find one of these cell lines that you could easily homogeneously grow in a culture dish, if they respond to mechanical force, can we find our channel there? And then go back and look if it's relevant in vivo for what process. So I think the message is ask the simplest question to answer the question you're after. And finding what that is, is actually the challenge lots of times.Ardem Patapoutian (10:36):But yeah, that's what Bertrand Coste in my lab did is found a simple cell line that neuroscientists had been using for a hundred years and somehow found that they over overexpressed this channel because you can record from them, you can push them and record the currents from them. And then it became a simpler question of finding it. It still took a whole year. He made a list and one by one knocking them out and looking at it. And finally, as you say, number 72 was the hit. When he knocked that out, the current was gone. And that's where we started believing that we have what we were looking for.Eric Topol (11:12):Were you all ever about ready to give up at that point?Ardem Patapoutian (11:16):Oh yeah. I mean that's another lesson. These are postdocs doing the work, right? And they're here three, four years and this was coming close to end of two years, and he didn't have anything yet. So we started talking about having a backup project and he started that and we said, okay, we were ordering this oligos 30 at a time because they're expensive. And so, the first 30 nothing, the second 30 nothing. And how many more are we going to do before we potentially give up? And we said, well, let's do at least a third and then decide, thank goodness it was in that last set.Eric Topol (11:54):Wow, that is so wild. Now what's happened since this discovery, which I guess when you published it in 2010, so it means 14 years ago, but we're on this exponential growth of learning that these piezo receptors are everywhere. They're doing everything. In fact, I recently put on Bluesky, PIEZO ion channels are to human physiology as GLP-1 drugs are to treating many diseases because it's just blowing up. And you've published on some of these of course, on itch and bladder function and vascular function. We'll get to maybe malaria, I mean, but even the cover of Science recently was about wet dog shakes and how animals shake because of water. These receptors are so fundamental to our function. So maybe you could comment, 15 years ago when you were doing the work and you're making this discovery, did you ever envision it was going to blow up like this?Ardem Patapoutian (12:57):Not to this level, but I should have. I think that this idea, again, that most of cell communication is through chemicals is of course a lot of it is true.Ardem Patapoutian (13:12):But it would be ridiculous for evolution to ignore all the physical forces, the pressures that cells experience. And once they do, you would think you would put an instructive way of sensing this pressure signal and using it beneficially to the system or the cell. And so, when we used to talk about pressure sensing at the beginning, there were a couple of touch, pain, maybe proprioception, hearing are like the poster children of pressure sensing. But I think what these molecules, as you say is enabling us is finding out the much more wider role that pressure sensing is playing in physiology and in disease that no one had thought seriously about. And this is, I compare sometimes the finding the PIEZO molecules. You're going in a dark room, and you need to find a door to get into there. And PIEZO is kind of that finding the door once you get in, now you use that molecule now to find physiology instead of the opposite way around. So by pursuing PIEZO expression and function, we're finding all these new roles that they play in physiology and in disease that we didn't think about. And because they're so specialized to sense tension, membrane tension, they don't do anything else. So if you see them expressed somewhere or if you see a function for them, you can bet that they are playing a role in sensing pressure. A lot of biology has kind of come from this hypothesis.Eric Topol (15:00):Well, I mean it is so striking to see the pervasiveness, and I do want to go back just for a second because when you name them PIEZO, you named it after the Greek word. How did you come to that name?Ardem Patapoutian (15:13):So Bertrand and I were actually sitting on Google Translate and we were typing pressure and trying to see what it's like in Greek or in Latin or different languages. His native French and my Armenian and píesi in Greek is pressure. And of course, what's really cool is that the word that more people know about this is piezoelectric device.Eric Topol (15:41):Oh, right.Ardem Patapoutian (15:41):Actually, translates physical force into electricity and vice versa. And in a way, this is a little molecular machine that does the same thing, and he uses this piezoelectric device to actually push on the cell. That's his assay. So it all came together as a very appropriate name for this gene and protein.Call from the Nobel CommitteeEric Topol (16:04):Oh really, it's perfect. And you get to name it, even that's fun too, right? Now we're going to go to getting the call at 2:00 AM, but it didn't come to you because your phone from the Nobel Committee was on ‘do not disturb' and your 94-year-old father, Sarkis. How did the Nobel Committee know to get ahold of him? How did they reach him in the middle of the night?Ardem Patapoutian (16:37):Yeah, so I mean, since receiving it, I've had conversations with various committee members, and they are very resourceful folks, and they have assistants who throughout the year collect information on all potential people who might win. They're also doing last minute searches. So they looked for other Patapoutian's in California. So they just called my dad who initially yelled at them for disturbing him at 2:00 AM.Eric Topol (17:17):And he could get through to you because he was not on your list of ‘do not disturb' or something like that.Ardem Patapoutian (17:22):I didn't even know this. And I don't know if the policy has changed, but in some phones the ‘do not disturb' if it's called by someone who's in your contacts or favorites.Ardem Patapoutian (17:34):After I think they called twice and they get through, and that's how.Getting a Tattoo!Eric Topol (17:39):That's amazing. Wow. Well, that's quite a way to find out that you're getting recognized like this. Now recently you got a tattoo, which I thought was really remarkable, but we're going to put that of course in the post. Tell us about your decision to get the PIEZO channel on your arm.Ardem Patapoutian (18:02):So as you can tell, I'm obsessed about PIEZO and it's been good to me. And I had the idea a while ago, and my very wise wife, Nancy Hong, said that you might be going through midlife crisis. Why don't you wait a year? If you still believe in it, you should do it. And that's what I did. I waited a year, and I was like, I still want to do it. And I guess I could show it. Here it is.Eric Topol (18:32):Oh yeah, there it is. Oh wow.Ardem Patapoutian (18:33):What's cool is that I can pretty much flex to show the activation mechanism because the channel is like bent like this in the plasma membrane. When it's stretched, it opens and it actually flattens like this. So I feel like other than being a tattoo, this is both performance art and instructional device. When I'm giving talks without PowerPoint slides, I could give a demonstration how this ion channel works.[Below is from a presentation that Ardem recently gave, the Harvey Lecture, at Rockefeller University.]Eric Topol (19:04):It's wild. Now how did you find a tattoo artist that could, I mean, it's pretty intricate. I mean, that's not your typical tattoo.Ardem Patapoutian (19:14):Yeah, I put it up on social media that I was thinking of doing this, and many scientists are into tattoos, so I actually got so many recommendations. And one of them was a local here in San Diego, and she is very popular. I waited six months to get this, I was on a waiting list. The appointment was six months off when we made it. So she's very popular and she's very good.Eric Topol (19:45):Was it painful to get that done?Ardem Patapoutian (19:47):Well, that's actually really cool, right? Because PIEZO2 is involved in pain sensation, and I felt it while it was being tattooed on my arm. The whole day, I was there like six and a half hours.New Prospect for Pain MedicationEric Topol (20:00):Oh my gosh. Wow. Now that gets me to pain because, I'd like you to talk a bit about the people that don't have mutations or loss of function PIEZO receptors and also what your thoughts are in the future as to maybe we could develop a lot better pain medications.Ardem Patapoutian (20:22):Yeah, we're working on it. So you're right. One of the great parts of the science story, and this is mainly the work of Alex Chesler and Carsten Bönnemann at the NIH, where they identified people who came to the clinic for undiagnosed conditions, and they were uncoordinated and had difficulty walking. And when they did whole-exome sequencing, they found that they had mutations in PIEZO2, there were loss of function, as you say. So complete loss on both chromosomes. And when they started testing them, they realized that just like we had described them in animal models, humans without PIEZO2 as well, didn't sense touch, don't have proprioception. This sense of where your limbs are, that's so important for balance and most other daily functions that we take it for granted. So they were completely lacking all of those sensations. They also do not feel their bladder filling.Ardem Patapoutian (21:26):And so, they have learned to go on a schedule to make sure they don't have accidents. And many of these projects that we've done in the lab collaboration with Alex Chesler, et cetera, have come from the observations of what else these individuals experience. And so, it's been a great kind of collaboration communication between mechanistic animal model studies and the clinic. And so, one of the things that these individuals don't sense in addition to touch, is something called tactile allodynia, which is simply when touch becomes painful. You and I experienced this after small injury or sunburn where just touching your shoulder becomes painful, but for peripheral neuropathy and other neuropathic pain conditions, this is one of the major complaints that individuals have. And we know from the NIH studies that these individuals don't have this tactile allodynia. So touch becomes painful and doesn't apply to them, which tells us that if we block PIEZO2, we can actually get interesting relief from various aspects relative to neuropathic pain on other pain related neuropathies. But given everything we talked about, Eric, about how this is important for touch and proprioception, you don't want to make a pill that blocks PIEZO2 and you take it because this will have some serious on target side effects. But we are developing new compounds that block PIEZO2 and hope that it might be useful, at least as a topical medication pain and other indications. And we're actively working on this, as I said.Eric Topol (23:15):Yeah, I mean the topical one sounds like a winner because of peripheral neuropathy, but also I wonder if you could somehow target it to sick cells rather than if giving it in a systemic targeted way. I mean it has tremendous potential because we are on a serious hunt for much better relief of pain than exists today.Ardem Patapoutian (23:41):Absolutely.Eric Topol (23:42):Yeah. So that's exciting. I mean, that's another potential outgrowth of all this. Just going back, I mean the one that prompted me in November to write that about the human physiology in PIEZO, it was about intestinal stem cell fate decision and maintenance. I mean, it's just everywhere. But the work you've done certainly now has spurred on so many other groups to go after these different and many unanticipated functions. Were there any ones, of course, you've been pretty systematically addressing these that actually surprised you? You said, oh, are you kidding me when you read this? I never would've guessed this, or pretty much they followed suit as things were moving along.Ardem Patapoutian (24:33):So one of them is this role in macrophages that I found fascinating that we found a few years ago. So again, this came from human studies where PIEZO1 gain-of-function mutations. So in relation to loss of function, their gain-of-function where there's more activity given a certain amount of pressure. They have dehydrated red blood cells, which I'm not going to talk about right now. But they also have shown that in these patients, individuals, it's not really that pathological. They also have age-onset iron overload. What does that have to do with pressure sensing? And we brought that information into animal models, and we found that macrophages, their rate of phagocytosis depends on PIEZO, so that if you have too little PIEZO, they don't phagocytosis as much. If you have too much PIEZO, the phagocytosis too much. And this increased rate of phagocytosis in the long term because it's constantly eating red blood cells and the iron is circulating more causes long-term effects in iron overload. And again, as you kind of set that up, who would've thought that mechanical sensation is important for this basic hematology type?Eric Topol (25:52):Yeah, I mean, because we've been talking about the macro things, and here it is at the cellular level. I mean, it's just wild.Ardem Patapoutian (25:59):If you go back and look at a video of a macrophage eating up red blood cells, then you go, oh, I see how this has to do with pressure sensing because it is like extending little arms, feeling things letting go, going somewhere else. So again, I want to bring it back by this simple cell biological function of a cell type, like macrophage, exploring its environment is not just chemical, but very mechanical as well. And so, in retrospect, it is maybe not that surprising, that pressure sensing is important for its physiology.Career Changing?Eric Topol (26:33):Yeah, that's extraordinary. Well, that gets me to how your life has changed since 2021, because obviously this a big effect, big impact sort of thing. And I know that you're the first Armenian, first person from Lebanon to get this recognition. You recognized by the Lebanese Order of Merit. There's even a stamp of you, your picture characterized in 2022.Eric Topol (27:04):So if you were to sum up how it's changed because I see no change in you. You're the same person that has a great sense of humor. Often the tries to humor relaxed, calming. You haven't changed any to me, but how has it affected you?Ardem Patapoutian (27:26):Thank you, Eric. That's very kind of you. I try very hard for it not to change me. I do get a little bit more attention, a ton more invites, which unfortunately I have to say no to a lot of them because, and I'm sure you're very familiar with that concept and a lot of things are offered to you that I feel like it's so tempting to say yes because they're wonderful opportunities and an honor to be asked. But the end of the day, I'm trying to be very disciplined and not taking things on that I can do as an opportunity. But things that I really want to do. I think that's so hard to do sometimes is to separate those two. Why am I doing this? Is this really important for the goals that I have? So in one way, the answer for that is that I just want to stay in the lab and do my research with my students and postdoc, which is what I enjoy the most. But on the other hand, as you said, being the first Armenian who's received this, literally after the Nobel, I got this whole elementary school, all Armenian kids write to me multiple letters.Ardem Patapoutian (28:39):And they said, you look like me. I didn't think I could do this, but maybe I can. So in a sense, to ignore that and say, no, I just want to do my science, I don't want to be involved in any of that is also wrong. So I'm trying to balance being engaged in science outreach and helping to make science understood by the general public, realize that we're just regular people and at the same time how awesome science is. I love science and I like to project that, but leave plenty of time for me to just be a scientist and be in my lab and interact with my colleagues at Scripps, including you.Immigrant ScientistsEric Topol (29:21):Well, we're so lucky to have that chance. And I do want to mention, because you're prototyping in this regard about great immigrant scientists and other domains of course, but every year the Carnegie Foundation names these great immigrants and one year you were of course recognized. And in recent years, there have been more difficulties in people wanting to come to the US to get into science, and they wind up going to other places. It seems like that's a big loss for us. I mean, what if we weren't able to have had you come and so many hundreds, thousands of others that have contributed to this life science community? Maybe you could comment about that.Ardem Patapoutian (30:10):Yeah, I think it is tragic, as you say. I think in some circles, immigrants have this negative image or idea of what they bring, but at every level, immigrants have contributed so much to this country. It's a country of immigrants, of course, to start with. And I think it is important to put up a positive image of immigration and science is the ultimate example of that, right? I mean, I think when you go into any laboratory, you probably find if there's a lab of 16 people, you probably find people from 10 different countries. And we all work together. And the idea of also immigrant and especially about science is that I'm a big believer of changing field, changing things because just like that, immigrants have changed their whole life. So they come to a new culture, they bring with them their own way of thinking and their way of seeing things. And then you come into a new environment, and you see it a little bit differently. So that kind of change, whether it's because of physical immigration or immigrating from one field to another in science is really beneficial for science and society. And I think positive examples of this are an important part of highlighting this.Eric Topol (31:40):I couldn't agree with you more really.Bluesky vs Twitter/XEric Topol (31:41):Now, speaking of migration, there's been recently a big migration out of X, formerly Twitter to Bluesky, which I like the metaphor you liken to the Serengeti. Can you tell us about, now I know you're posting on Bluesky and of course so many others that you and I are mutual contacts, and our different networks are. What do you think about this migration outside of what was the platform where a lot of this, we shared things on X or before Musk took over known as Twitter? Thoughts about Bluesky?Ardem Patapoutian (32:27):Yeah, I think I use social media for a few reasons. The number one reason should be is to see new science by colleagues. My main point is that, but also, again, having fun in science is a big part of my draw to this. And as you can see from my posts, it's a bit lighthearted, and that's really me.Eric Topol (32:52):Right. Yeah.Ardem Patapoutian (32:52):I think on Twitter, things start getting a little bit dark and too many negative comments, and it was just not productive. And I just felt like after the elections, I felt like it was time to migrate. And I find Bluesky a great scientific community, and it's remarkable how quickly people have migrated from Twitter to Bluesky. But the counter argument for this is that you should stay in a place where majority of people are, because being in a bubble surrounding yourself by people like you doesn't help society. And so, I get that perspective as well. It just depends on what you're using the platform for and it's a difficult issue. But yeah, I've taken a break probably long-term break from Twitter. I'm on Bluesky now.Eric Topol (33:48):Yeah, no, the point you're bringing up about the echo chamber and is there going to be one for people that are leaning one way and they're thinking, and another with a whole different, often politically charged and even extreme views? It's really unfortunate if it does wind up that way. But right now, it seems like that migration is ongoing and it's substantial. And I guess we'll see how it settles out. I share your concern, and so far, I've been trying to keep a foot in both areas because I think if we all were to leave, then we're just kind of caving into a, it's tricky though. It really is because the noxious toxic type of comments, even when you try to avoid comments, you say, only followers can make a comment, they'll of course, quote your thing and then try to ding you and whatever. It's just crazy stuff, really.Ardem Patapoutian (34:53):I mean, what I think is that, that's why I said depends on why. I mean, your presence on social media is such an important part of science education. And I could almost say you can't afford to do what I do, which is I'm just putting my goofy posts and having fun. So we have different purposes in a way, and yeah, that affects what you use and how you use it.Eric Topol (35:17):Yeah, no, it's tricky it really is. We covered a lot of ground. Is there anything I missed that you want to get out there? Any part of this, your story and the PIEZO story, science and everything else that I didn't bring up?The Essentiality of Basic ScienceArdem Patapoutian (35:42):I just think that the basic science community is really suffering from decreasing amounts of funding and appreciation of doing basic science. And one of my goals, in addition to this immigrant scientist thing, is to remind people that all medicines start with basic science work. And funding this has mainly been through NIH and it's getting harder and harder for basic scientists to secure funding and I'm really worried about this. And we need to find ways to be okay for people to do basic science. And I'll give you one example. Whenever we make a publication and there's a journalist talking to us or some kind of press coverage, they ask, how is this directly affecting patients? And my work actually is very much related to patients, and I answer that question, but I also say, but it's also important to do science for the science sake because you don't know where the applications are going to come from. And we need to, as a society, encourage and fund and support basic science as the seeds of all these translational work. And I think doing that just kind of highlights that this is important too. We should support it, not just things that right now seem very related to translational that directly helps patients.Eric Topol (37:16):Well, I'm so glad you emphasized that because I mean, the PIEZO story is the exemplar. Look what's come of it, what might still come of it. In many respects here you are maybe 15 years into the story and there's still many parts of this that are untold, but if it wasn't for the basic science, we wouldn't have these remarkable and diverse insights. And recently you cited, and I think so many people read about the ‘crown jewel' NIH, front page New York Times, and how it's under threat because the new NIH director doesn't have a regard for basic science. He's actually, he's confirmed, which is likely, he's an economist, physician economist, never practiced medicine, but he doesn't really have a lot of regard for basic science. But as you point out, almost every drug that we have today came out of NIH basic work. And I mean, not just that, but all the disease insights and treatments and so much.Eric Topol (38:25):So this is really unfortunate if we have not just an NIH and other supporting foundations that don't see the priority, the fundamental aspect of basic science to then lead to, as we call translational, and then ultimately the way to promote human health, which is I think what we're all very much focused on ultimately. But you can't do it without getting to first base, and that's what you have done. You served it up and it's a great example. Well, Ardem, it's always a pleasure. This is a first time talking through a podcast. I hope we'll have many, many visits informally that will complement the ones we've already had, and we will follow the PIEZO work. Obviously, you have had just an exceptional impact, but you're still young and who knows what's next, right? I mean, look what happened to Barry Sharpless. He won here. He won two Nobel prizes, so you never know where things are headed.Ardem Patapoutian (39:36):Thank you, Eric, and I really appreciate what you do for the biomedical community. I think it's wonderful through your social media and this podcast, we all appreciate it.***********************************************************************************Please take a moment to complete the poll above.Thank you for reading, listening and subscribing to Ground Truths.If you found this informative please share it!All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.Paid subscriptions are voluntary and of course appreciated. All proceeds from them go to support Scripps Research. Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. I welcome all comments from paid subscribers and will do my best to respond to each of them and any questions.Thanks to my producer Jessica Nguyen and to Sinjun Balabanoff for audio and video support at Scripps Research.And Happy New Year! Get full access to Ground Truths at erictopol.substack.com/subscribe

To wrap up 2024, science writer Riley Black shares her favorite paleontology discoveries of the year. And, if treated properly, even old-fashioned eggnog made with cream and raw eggs can be a safe holiday beverage.The Most Exciting Dino Discoveries Of 2024December is, traditionally, a time to reflect on the events of the past year—including dinosaur discoveries. In 2024, researchers learned more about T. rex and the spiky tails of stegosaurs as well as how dinosaurs evolved, lived, and more.For Smithsonian Magazine, dinosaur enthusiast and science writer Riley Black rounded up her top dino discoveries of the year. She talks with Ira Flatow about the most exciting paleontology news of 2024.Can Spiking Eggnog Kill Bacteria From The Raw Eggs?It's a question that occasionally comes up over the course of a holiday celebration, at least in certain circles: whether or not the alcohol in old-fashioned eggnog made with real cream and raw eggs can protect against foodborne pathogens such as salmonella.Around 15 years ago, Science Friday investigated, enlisting the help of a lab at Rockefeller University that has a tradition of mixing up a big batch of old-fashioned eggnog around Thanksgiving, then serving it weeks later at a lab holiday party. The researchers kindly conducted a controlled study in which they deliberately spiked samples of their potent eggnog with salmonella, then followed the mixture's bacterial status over the course of several weeks.Science Friday's Charles Bergquist checks in with Dr. Vincent Fischetti, a bacteriologist at Rockefeller, to see if there have been any advances in the field of eggnogology.Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Support the show to get full episodes and join the Discord community. The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. Read more about our partnership: https://www.thetransmitter.org/partners/ Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: https://www.thetransmitter.org/newsletters/ To explore more neuroscience news and perspectives, visit thetransmitter.org. Hessam Akhlaghpour is a postdoctoral researcher at Rockefeller University in the Maimon lab. His experimental work is in fly neuroscience mostly studying spatial memories in fruit flies. However, we are going to be talking about a different (although somewhat related) side of his postdoctoral research. This aspect of his work involves theoretical explorations of molecular computation, which are deeply inspired by Randy Gallistel and Adam King's book Memory and the Computational Brain. Randy has been on the podcast before to discuss his ideas that memory needs to be stored in something more stable than the synapses between neurons, and how that something could be genetic material like RNA. When Hessam read this book, he was re-inspired to think of the brain the way he used to think of it before experimental neuroscience challenged his views. It re-inspired him to think of the brain as a computational system. But it also led to what we discuss today, the idea that RNA has the capacity for universal computation, and Hessam's development of how that might happen. So we discuss that background and story, why universal computation has been discovered in organisms yet since surely evolution has stumbled upon it, and how RNA might and combinatory logic could implement universal computation in nature. Hessam's website. Maimon Lab. Twitter: @theHessam. Related papers An RNA-based theory of natural universal computation. The molecular memory code and synaptic plasticity: a synthesis. Lifelong persistence of nuclear RNAs in the mouse brain. Cris Moore's conjecture #5 in this 1998 paper. (The Gallistel book): Memory and the Computational Brain: Why Cognitive Science Will Transform Neuroscience. Related episodes BI 126 Randy Gallistel: Where Is the Engram? BI 172 David Glanzman: Memory All The Way Down Read the transcript. 0:00 - Intro 4:44 - Hessam's background 11:50 - Randy Gallistel's book 14:43 - Information in the brain 17:51 - Hessam's turn to universal computation 35:30 - AI and universal computation 40:09 - Universal computation to solve intelligence 44:22 - Connecting sub and super molecular 50:10 - Junk DNA 56:42 - Genetic material for coding 1:06:37 - RNA and combinatory logic 1:35:14 - Outlook 1:42:11 - Reflecting on the molecular world

It's fair to say that enjoyment of a podcast would be severely limited without the human capacity to create and understand speech. That capacity has often been cited as a defining characteristic of our species, and one that sets us apart in the long history of life on Earth. Yet we know that other species communicate in complex ways. Studies of the neurological foundations of language suggest that birdsong, or communication among bats or elephants, originates with brain structures similar to our own. So why do some species vocalize while others don't? In this episode, Erich Jarvis, who studies behavior and neurogenetics at the Rockefeller University, chats with Janna Levin about the surprising connections between human speech, birdsong and dance.

  In this episode of “Don't Take No for An Answer,” Eric Jesse, partner in Lowenstein Sandler's Insurance Recovery Group, is joined by Alexander B. Corson to discuss bad faith in insurance claims. Highlighting a recent example of a case involving Rockefeller University, Eric and Alex explain how breach of contract claims are different from bad faith claims, why choice of law matters, and how policyholders can protect themselves against insurers who sit on their hands. Speakers: Eric Jesse, Partner, Insurance RecoveryAlexander B. Corson, Associate, Insurance Recovery

Today, we're honored to have the extraordinary Casey Whalen in the suite—Managing Director, Head, and Chief Investment Officer at Lazard Family Office Partners, a global powerhouse in financial advisory and asset management. Lazard's influence spans continents, from the Americas to Europe, the Middle East, Asia, and beyond.In this episode, we dive deep into themes of resilience, risk-taking, and seizing pivotal opportunities. Casey's story is about mentorship, grit, and knowing when to act. One of her defining moments? Her mentorship under the legendary David Swensen, Yale's Chief Investment Officer. Fresh out of Yale with a degree in economics, Casey was already making waves at the university's endowment, cutting her teeth across various asset classes. This set the stage for her impressive rise.Her journey took her to Brookdale Realty in Atlanta, then back to the Northeast, where she joined The Rockefeller University as Director of Public Investments. At just 30, Casey became the New York Public Library's first-ever Chief Investment Officer, building an investment office from scratch and implementing groundbreaking processes to manage its endowment. Her career is a testament to bold leadership and innovation.But this isn't just a career highlight reel. Casey opens up about the personal challenges she's faced, the importance of mentorship, and how macroeconomic trends are shaping the future of investments. We also explore why gender balance in firms is a competitive edge and how diverse teams drive innovation.Packed with raw insights and invaluable lessons, this episode is a must-listen for anyone looking to lead, break barriers, and thrive In The Suite.

Brent grew up in the college town of Fayetteville, Arkansas, and is the son of a teacher/school administrator (dad) and a successful real estate broker (mom). On a family trip to NYC when Brent was in grade school, he saw Ethel Merman in Hello, Dolly! This sparked a love of theater and eventually a move to Manhattan to pursue a career in musical theater. Brent has performed off-Broadway, in regional theaters across the US, and on cruise ships worldwide for over ten years. In the late 1990s, Brent left the theater and began working in non-profit administration, spending almost 20 years as the business manager for a Nobel laureate in a research laboratory at Rockefeller University.A friend from his theater days introduced Brent to Asbury Park, NJ, in the early 2000s when the city changed from a gritty ghost town to a Jersey Shore Mecca for gays wanting to nab an affordable house near the beach. After many vacation trips to Asbury, Brent and his husband bought their first shore home in 2011.Brent retired early at the end of the pandemic and started a new career in real estate, following in his mother's footsteps. He enjoys making many new friends, as his mother did, and helping to find the perfect shore home for his clients.Brent enjoys small-town life. Now in his third Asbury home, he lives with his husband Joe, also a former actor turned non-profit professional, and their mini-Aussiedoodle Dickens.SummaryBrent Winborn shares his journey to Asbury Park, New Jersey, highlighting the city's transformation from a gritty ghost town to a vibrant LGBTQ+ mecca. He describes Asbury Park's geographical overview, unique perspectives, and proximity to New York City and Philadelphia. Brent also discusses the climate, which has four seasons but milder winters and longer fall periods. He emphasizes the strong LGBTQ+ community in Asbury Park, the presence of gay bars and hotels, and the sense of community and acceptance. Brent also provides insights into the cost of living, including home prices, rentals, utilities, and groceries. Asbury Park offers diverse housing options, from newer condos to renovated older buildings. The vibrant cultural scene has festivals, music events, theaters, and galleries. The restaurant scene is diverse, with options ranging from dive bar burgers to high-end dining. Asbury Park is a walkable city, and while public transportation is limited, e-scooters and e-bikes are popular for getting around. Safety is not a major concern, and excellent healthcare facilities are nearby. Challenges include parking availability and the need for more hotels. Overall, Asbury Park offers a unique small-town atmosphere with an urban feel.For NJ State Tax info on Social Security, Pensions, 401K's and IRA's Is There an E Street? Where?E Street runs northeast through the New Jersey shore town of Belmar. According to Springsteen lore, the band took its name from the street because original keyboard player David Sancious's mother lived there and allowed the band to rehearse in her house. The titular avenue of "Tenth Avenue Freeze-Out" is also in Belmar.

Synopsis: In this engaging episode, host, Rahul Chaturvedi welcomes Marshall Fordyce, Founder and CEO of Vera Therapeutics, to discuss his transformative journey from physician to biotech entrepreneur. Marshall shares the story behind Vera Therapeutics' strategic pivot to focus on IG nephropathy and their development of atacicept, a promising B-cell modulator. He provides valuable insights into the biotech industry's landscape, emphasizing the importance of scientific rigor, adaptability, and maintaining a lean, effective operating model. Marshall's enthusiasm for advancing autoimmune disease treatments and his advice for aspiring entrepreneurs make this a must-listen episode. Biography: Dr. Fordyce brings more than 15 years' experience leading teams in drug discovery, development, clinical translation, and commercialization of new treatments. Before founding Vera, Fordyce was the founder and CEO of gene-editing company Trucode Gene Repair, Inc., having previously served as an entrepreneur in residence at Kleiner Perkins Caufield and Byers. Earlier in his career, Fordyce served as Senior Director of clinical research at Gilead Sciences, Inc., where he contributed to seven new drug approvals and served as project lead for Gilead's TAF/GENVOYA development program. With subspecialty training in infectious disease from Columbia University Vagelos College of Physicians and Surgeons, Fordyce was previously Chief Resident at NYU Bellevue and spent two years as a translational research fellow at Rockefeller University. Fordyce currently serves on the Board of Directors of the Albert and Mary Lasker Foundation. He received his BA from Harvard University and his MD from Harvard Medical School.

Dr. Paul Szabolcs trained at Semmelweis University School of Medicine in Budapest. He completed his residency at Bellevue Hospital/NYU Medical Center and was Chief Fellow at Sloan Kettering Cancer Center in New York City. He completed postdoctoral fellowships at Memorial Sloan Kettering in Molecular Biology and at Rockefeller University in Physiology and Cellular Immunology. He has been Chief of the Blood and Marrow Transplantation and Cellular Therapies division at the UPMC Children's Hospital of Pittsburgh since 2011. Dr. Szabolcs has dedicated his career to developing effective “reduced-intensity” chemotherapy regimens for patients in need of a blood or bone marrow transplant, especially children with rare immune-system defects and degenerative brain diseases.

Dr. Ben Bikman's lecture on leptin, delivered in his Metabolic Classroom series, highlights the hormone's critical role in metabolism. Leptin, primarily produced by white fat tissue, helps regulate energy balance by signaling the brain to suppress appetite and promoting mitochondrial biogenesis in muscle cells. Leptin levels correlate with body fat, and various factors like insulin and TNF alpha influence its production. Insulin significantly stimulates leptin secretion, highlighting a complex interplay between these hormones.Leptin resistance, a condition where the body fails to respond effectively to leptin despite high levels, is similar to insulin resistance and often occurs in individuals with higher body fat. This leads to compromised satiety signals, energy expenditure, and potential obesity. Dr. Bikman also explores leptin's broader effects on reproductive health, thyroid function, immune function, vascular health, and bone formation. These diverse roles underline leptin's significance in the body.A historical perspective reveals leptin's discovery in 1994 by Dr. Jeff Friedman's lab at Rockefeller University. They found that leptin played a crucial role in regulating body weight in mice. However, leptin injections in obese humans did not yield similar results, as most obese individuals already have high leptin levels, leading to the understanding that leptin resistance, not a lack of leptin, is the issue in obesity.The lecture concludes with practical insights on addressing leptin resistance, emphasizing the importance of controlling blood glucose and insulin levels, particularly through low-carb diets. This approach helps reduce leptin levels and improve leptin sensitivity, offering a pathway to better metabolic health and weight control. Hosted on Acast. See acast.com/privacy for more information.

Guest Bio: Among the most distinguished classical artists of his generation, clarinetist Jon Manasse is internationally recognized for his inspiring artistry, uniquely glorious sound and charismatic performing style. Jon Manasse's solo appearances include New York City performances at Lincoln Center for the Performing Arts' Avery Fisher Hall and Alice Tully Hall, Hunter College's Sylvia & Danny Kaye Playhouse, Columbia University, Rockefeller University and The Town Hall, fourteen tours of Japan and Southeast Asia – all with the New York Symphonic Ensemble, debuts in Jerusalem, Tel Aviv, and Osaka and concerto performances with Gerard Schwarz and the Mostly Mozart Festival Orchestra, both at Lincoln Center's Avery Fisher Hall and at the prestigious Tokyu Bunkamura Festival in Tokyo.  Jon Manasse is a graduate of The Juilliard School, where he studied with David Weber.  Mr. Manasse was a top prize winner in the Thirty-Sixth International Competition for Clarinet in Munich and the youngest winner of the International Clarinet Society Competition. Currently, he is an official “Performing Artist” of both the Buffet Crampon Company and Vandoren, the Parisian firms that are the world's oldest and most distinguished clarinet maker and reed maker, respectively. Mr. Manasse is currently on the faculties of The Juilliard School,The Lynn Conservatory, and The Mannes School of Music. Jon Manasse and his Duo partner, the acclaimed pianist Jon Nakamatsu, serve as Artistic Directors of the Cape Cod Chamber Music Festival, an appointment announced during summer 2006.   Learn more about Jon at https://jonmanasse.com/ Support the show at www.patreon.com/clarineat

Dr. John Aitchison is President and Director of the Center for Infectious Disease Research, the largest independent, non-profit organization in the U.S. that is focused solely on infectious disease research. In addition, John serves as an affiliate or adjunct Professor at the University of Washington, the University of British Columbia, the University of Alberta, and the Institute for Systems Biology. John's research investigates the systems biology related to infectious disease by using technology, computation, and high throughput biology to examine molecules in complex biological systems to better understand how the system will react to a new stimulus or perturbation. Their ultimate goal is to predict how effective a drug or vaccine will be against a particular disease and to implement it with high efficiency. When he's not in the office or the lab, John loves to be out on the water sailing and racing sailboats. He's also a fan of playing squash, skiing, spending time with his family, and being outdoors. John received his B.Sc. degree with Honors in Biochemistry from McMaster University and his Ph.D. in Biochemistry from McMaster University as well. He then conducted postdoctoral research in the Laboratory of Cell Biology at The Rockefeller University. Next, John served on the Faculty of Medicine and Dentistry at the University of Alberta. Afterwards, he became a founding member at the Institute for Systems Biology where he later served as Senior Vice President and Executive Director of Integrative Biology. While working at the Institute for Systems Biology, John also began conducting research at the Center for Infectious Disease Research where he still works today. In our interview John shares his experiences in life, leadership, and science.

Today, we're delving into a topic that's both profound and hopeful: the harm of childhood trauma and the incredible power of resilience. Joining me on the show is Dr. Marc D. Hauser, who's here to unravel these complex topics in a way that's accessible and empowering for all parents. Through his groundbreaking work, including his new book Vulnerable Minds: The Harms of Childhood Trauma and the Hope of Resiliency, which is what we're diving into today, Marc brings scientific evidence about childhood trauma to a broader audience and sheds light on the pathways to healing and growth. In this conversation, we explore what constitutes a traumatic experience and why neurodivergent children may be more vulnerable to their effects, as well as ACES, or Adverse Childhood Experiences, often misunderstood but profoundly influential in shaping a child's journey. Marc helps us understand their significance in the context of resilience.   About Marc Hauser Marc Hauser is a scientist, educator, author, consultant and public speaker. Hauser's scientific research, including over 300 published papers and seven books, has focused on how the brain evolves, develops, and is altered by damage and neurodevelopmental disorders, with an emphasis on the processes of learning and decision-making, as well as the impact of traumatic experiences on development. Hauser's educational and consulting work has focused on the implementation of quantitative, brain-based methods for teachers, clinicians, and doctors working with children who have different disabilities, including especially those that result from a history of traumatic experiences. Hauser earned a Bachelor of Science degree from Bucknell University, a PhD from UCLA and Post-doctoral fellowships from the University of Michigan, Rockefeller University, and University of California-Davis. From 1992-2011, he was a Professor at Harvard University. In 2013, he founded the company Risk-Eraser, dedicated to providing software and consulting to programs focusing on students in special education. His most recent book Vulnerable Minds, published in March 2024 by Avery-Penguin-Random House Publishing, New York.   Things you'll learn from this episode How Vulnerable Minds makes scientific evidence about childhood trauma accessible to a broader audience How traumatic experiences are defined The impact of trauma on neurodivergent children as well as ways in which these kids are more vulnerable to trauma What it means for a school to be trauma-informed in action What ACES are and how their assignment and meaning is frequently misinterpreted and misunderstood The role of nature and nurture when it comes to whether other not an experience results in trauma or is met with resiliency   Resources mentioned for the Harm of Childhood Trauma and the Hope of Resiliency Dr. Marc D. Hauser's author website Vulnerable Minds: The Harms of Childhood Trauma and the Hope of Resiliency by Dr. Marc D. Hauser International Children's Aid Network (iCAN) Marc Hauser on X Marc Hauser on Instagram Marc Hauser on Linkedin Marc Hauser on Facebook Dr. Vincent Falliti Stephen Porges and Polyvagal Theory The Impact of Adverse Childhood Experiences on Health and Development in Young Children (National Institute of Health Study) The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma by Bessel van der Kolk, MD What Happened to You? Conversations on Trauma, Resilience, and Healing by Bruce Perry and Oprah Winfrey Kelly Mahler on Understanding and Supporting Kids' Interoception Experience (Tilt Parenting Podcast) Lori Desautels on Shifting Educational Systems Toward Post-Traumatic Growth (Tilt Parenting Podcast) Revelations in Education, Dr. Lori Desautel's website Intentional Neuroplasticity: Our Educational Journey Towards Post Traumatic Growth by Dr. Lori Desautels   Learn more about your ad choices. Visit megaphone.fm/adchoices

What modern Indian genomes say about the region's deep past, and how vitamin A influences stem cell plasticity First up this week, Online News Editor Michael Price and host Sarah Crespi talk about a large genome sequencing project in India that reveals past migrations in the region and a unique intermixing with Neanderthals in ancient times.   Next on the show, producer Kevin McLean chats with Matthew Tierney, a postdoctoral fellow at Rockefeller University, about how vitamin A and stem cells work together to grow hair and heal wounds.   This week's episode was produced with help from Podigy.   About the Science Podcast   Authors: Sarah Crespi; Kevin McLean; Michael Price Episode page: https://www.science.org/doi/10.1126/science.zfhqarg   About the Science Podcast: https://www.science.org/content/page/about-science-podcast

Dr. Alan R. Saltiel is Distinguished Professor of Medicine and Pharmacology, Maryam Ahmadian Endowed Chair in Metabolic Health, Director of the Institute for Diabetes and Metabolic Health at UC, San Diego, and Director of the UCSD/UCLA Diabetes Research Center. Alan studies how cells that are involved in metabolism decide to take up and store energy, burn energy, or release energy for other cells to use in response to hormones, nutritional cues, and metabolic stress. He is particularly interested in studying cells in liver and fat tissues and better understanding the pathways involved in controlling the metabolic activities of these cells. When he's not working, Alan enjoys exercise and physical activity, including tennis and occasionally basketball. He also likes to read fiction and non-fiction, spend time with friends and family, and experiment with cooking Mediterranean cuisine. He received his bachelor's degree in zoology from Duke University, and his Ph.D. in biochemistry from the University of North Carolina. Afterwards, he conducted postdoctoral research at the Wellcome Research Laboratories. Alan served on the faculty at Rockefeller University before joining Parke Davis Pharmaceutical Research in 1990, where he remained until 2001 when he accepted a position at the University of Michigan. He transitioned to his current positions in 2015. Alan has received numerous awards and honors, including the Rosalyn Yalow Research and Development Award from the American Diabetes Association; the Hirschl Award from Hirschl Trust; the John Jacob Abel, Goodman and Gilman, and Pharmacia-ASPET Awards from the American Society of Pharmacology and Experimental Therapeutics, and he was named a Fellow of the Society in 2022. In addition, Alan is an elected Fellow of the American Association for the Advancement of Science, an elected Member of the American Society of Clinical Investigation, and an elected Member of the National Academy of Medicine. In this interview, Alan shares more about his life and science.

Do we have free will? Do we have a choice in what we do? Philosophers and theologians have debated these questions for centuries; Robert Sapolsky answered them when he was 14. Free will, he concluded, simply does not exist. Robert is now in his mid-sixties. He has degrees from Harvard and Rockefeller University; he won a MacArthur “genius” award; and he's a professor at Stanford, where he holds joint appointments in biology, neurology, and neurosurgery. But despite how much time has passed and how long his CV has grown, he never lost his youthful fascination with free will — or our lack thereof — so he decided to write a book about it. It's called “Determined,” and in addition to assembling a formidable case against free will, Robert makes the intriguing argument that if we can abandon our illusion of volition, we can build a more humane world. Support the show by becoming a Next Big Idea Club member. (Use code PODCAST for 20% off.) We're hosting a live taping in New York City on January 31st. Come on by! We'd love to meet you. You can learn more here.