ICU Primary PrepCast

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This podcast is about Intensive care pharmacology and physiology. This is created to prepare intensive care trainees for their primary CICM exams. However, it will be of benefit to anyone who works in intensive care and keen to acquire new knowledge or want to refresh their memory.

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    • Mar 25, 2025 LATEST EPISODE
    • infrequent NEW EPISODES
    • 17m AVG DURATION
    • 95 EPISODES


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    Latest episodes from ICU Primary PrepCast

    Epi 95 - ICU Primary Snippet 38 - Work of Breathing and Lung Efficiency

    Play Episode Listen Later Mar 25, 2025 9:10


    In this episode, we discuss the concept of Work of breathing and lung efficiency.

    work breathing primary efficiency lung snippet
    Epi 94 - ICU Primary Snippet 36 - Femoral Vein anatomy

    Play Episode Listen Later Sep 29, 2024 5:55


    In this episode, we discuss the procedural anatomy of the femoral vein including surface 

    anatomy primary snippet vein femoral
    #Epi 93 - ICU Primary Snippet 36 - Fibrinolysis and Alteplase

    Play Episode Listen Later Sep 22, 2024 5:54


    In this episode, we discuss the process of fibrinolysis in relation to coagulation cascade and the pharmacology of Alteplase.

    primary snippet alteplase fibrinolysis
    #Epi 92 - ICU Primary Snippet 35 - Remifentanyl Vs Fentanyl

    Play Episode Listen Later Sep 14, 2024 8:00


    In this episdoe, we compare and contrast fentanyl and remifentanyl.

    primary fentanyl snippet
    #Epi 91 - ICU Primary Snippet 34 - Receptors - Agonist, Partial agonist and Inverse agonist

    Play Episode Listen Later May 19, 2024 8:32


    in this episode, we discuss the role of various receptors and describe the terms - partial agonist, antagonist, and inverse agonists.

    primary partial snippet inverse receptors agonist
    #Epi 90 - ICU Primary Snippet 33 - Venous Admixture and effect of Supplemental Oxygen

    Play Episode Listen Later May 16, 2024 7:27


    In this episode, we discuss the concept of venous admixture and the effect of supplemental oxygen on it in adults.

    primary oxygen supplemental snippet venous
    Epi 89 - ICU Primary Snippet 32 - Effect of sudden and sustained increase in afterload on LV.

    Play Episode Listen Later May 7, 2024 7:33


    In this episode, we discuss the consequences of sudden and sustained afterload increase on the Left ventricle.

    left primary sustained snippet afterload
    #Epi 88 - ICU Primary Snippet 31 -Furosemide Vs Acetazolamide

    Play Episode Listen Later Apr 11, 2024 8:48


    In this episode, we discuss the differences between two diuretic medications - Furosemide and Acetazolamide.

    primary snippet furosemide
    #Epi 87 - ICU Primary Snippet 30 - Opioid Receptors

    Play Episode Listen Later Apr 1, 2024 7:16


    In this episode, we discuss various opioid receptors, their characteristics, distribution and activation process.

    primary opioids snippet receptors
    #Epi 86 - ICU Primary Snippet 29 - Renal Physiology - Urine concentrating mechanisms

    Play Episode Listen Later Mar 16, 2024 9:46


    In this episode, we discuss various mechanisms by which the kidney concentrates urine.

    primary physiology urine mechanisms snippet renal concentrating
    #Epi 85 - ICU Primary Snippet 28 - Neonatal Physiology Cardiovascular Changes

    Play Episode Listen Later Dec 15, 2023 13:41


    In this episode, we discuss the CVS changes after the birth.

    primary cvs physiology cardiovascular snippet neonatal
    #Epi 84 - ICU Primary Snippet 27 - Neonatal Physiology Part 1

    Play Episode Listen Later Nov 27, 2023 9:56


    In this episode, Dr Mike Clifford talks about respiratory changes occurring at birth. 

    primary physiology snippet neonatal
    #Epi 83 - ICU Primary Snippet 26 - Uteroplacental Circulation

    Play Episode Listen Later Oct 27, 2023 10:25


    In this episode, we discuss the key characteristics of uteroplacental circulation, including double Bohr and double Haldane effect.

    primary circulation snippet bohr haldane
    # Epi 82 - ICU Primary Snippet 25 - CVS changes during Pregnancy and at Term.

    Play Episode Listen Later Oct 16, 2023 9:48


    In this episode, Mike and I discuss the physiological changes in the cardiovascular system during pregnancy and at the term, their implication on pharmacokinetics.

    pregnancy primary snippet
    #Epi 81 - ICU Primary Snippet 24 - Respiratory changes during Pregnancy and Term

    Play Episode Listen Later Oct 3, 2023 10:16


    In this episode, Mike and I discuss the respiratory changes during the pregnancy and at the term.

    pregnancy primary respiratory snippet
    #Epi 80 - ICU Primary Snippet 23 - Control of Breathing

    Play Episode Listen Later Jul 16, 2023 12:55


    In this episode, we discuss the control of breathing and its clinical relevance.

    breathing primary snippet
    #Epi 79 - ICU Primary Snippet 22 - Arterial Pressure Transducers

    Play Episode Listen Later Jul 7, 2023 8:33


    In this episode, Mike discusses arterial pressure transducers, including natural frequency, resonance and damping.

    pressure primary snippet arterial transducers
    #Epi 78 - ICU Primary Snippet 21 - CO2 carriage in Blood

    Play Episode Listen Later Jun 29, 2023 7:47


    In this podcast, we discuss CO2 carriage in blood.

    blood primary co2 snippet carriage
    #Epi 77 - ICU Primary Snippet 20 - Structure of Adult Haemoglobin

    Play Episode Listen Later Jun 17, 2023 6:30


    In this episode, we discuss the structure and functions of adult haemoglobin.

    adult structure primary snippet haemoglobin
    # Epi 76 - ICU Primary Snippet 19 - pK/pD changes at Term in Pregnancy

    Play Episode Listen Later Jun 11, 2023 7:08


    In this episode, we discuss various pharmacokinetic and pharmacodynamic changes that take place at term during pregnancy.

    pregnancy primary snippet
    # Epi 75 - ICU Primary Snippet 18 - Factors affecting Cardiac Output

    Play Episode Listen Later Jun 4, 2023 10:20


    In this snippet, we cover all the physiological factors affecting Cardiac output. 

    primary factors affecting output cardiac snippet
    # Epi 74 - ICU Primary Snippet 17 - Factors affecting Airway resistance

    Play Episode Listen Later May 28, 2023 8:49


    In this episode, we discuss various physiological factors affecting airway resistance.    

    resistance primary factors affecting snippet airway
    # Epi 73 - ICU Primary Snippet 16 - West Zones

    Play Episode Listen Later May 21, 2023 9:50


    In this episode, Dr Mike Clifford explains the physiology of West Zones.

    west primary zones snippet
    # Epi 72 - ICU Primary Snippet 15 - GTN Pharmacology

    Play Episode Listen Later May 8, 2023 7:32


    in this episode, we discuss the pharmacology of GTN.

    primary snippet pharmacology gtn
    # Epi 71 - ICU Primary Snippet 14 - Principles of Hemofiltration and Hemodialysis

    Play Episode Listen Later Apr 16, 2023 10:04


    In this episode, Mike talks about the principles of Hemofiltration and hemodialysis, along with the composition of fluid used in dialysis. 

    principles primary snippet hemodialysis
    #Epi 70 - ICU Primary Snippet - Brain stem reflexes

    Play Episode Listen Later Mar 28, 2023 9:05


    In this episode, Dr Mike Clifford explains the pathways for corneal, pupillary light, oculomotor and gag reflexes. 

    brain stem primary snippet reflexes
    # Epi 69 - ICU Primary Snippet 12 - Physiological Control of SVR

    Play Episode Listen Later Mar 24, 2023 7:16


    In this podcast, Maddi and I discuss the factors affecting SVR. 

    primary snippet physiological svr
    # Epi 68- ICU Primary Snippet 11 - Factors affecting PaCO2

    Play Episode Listen Later Mar 16, 2023 6:01


    In this episode, Maddi covers various factors affecting PaCO2 levels.  

    primary factors affecting snippet paco2
    # Epi 67- ICU Primary Snippet 10 - Doppler Effect and Properties of Ultrasound transducers

    Play Episode Listen Later Mar 11, 2023 9:17


    In this episode, we discus briefly the physics of ultrasound, the Doppler effect and the properties of transducers.

    primary properties ultrasounds snippet doppler doppler effect transducers
    # Epi 66- ICU Primary Snippet 9 - Classification of Anti-psychotics and Haloperidol pharmacology

    Play Episode Listen Later Mar 3, 2023 5:57


    In this episode, we discuss the classification of anti-psychotic medications and haloperidol pharmacology in depth.

    primary classification snippet pharmacology haloperidol
    # Epi 65- ICU Primary Snippet 8 - Body water regulation

    Play Episode Listen Later Feb 23, 2023 11:52


    In this episode, we discuss various mechanisms for body water regulation.

    body water primary regulation snippet
    # Epi 64 - ICU Primary Snippet 7 - Factors affecting Mixed Venous oxygen saturations

    Play Episode Listen Later Feb 15, 2023 5:50


    In this episode, we discuss the concept of mixed venous oxygen saturation and various factors affecting it. 

    mixed primary factors affecting oxygen snippet venous
    # Epi 63 - ICU Primary Snippet 6 - Pharmacology of 4% Albumin

    Play Episode Listen Later Feb 9, 2023 7:29


    In this episode, we discuss the pharmacology of 4% albumin. 

    primary snippet pharmacology albumin
    # Epi 62 - ICU Primary Snippet 5- iNO and Prostacyclins

    Play Episode Listen Later Feb 1, 2023 5:40


    In this epsiode, we discuss the MOA and adverse effects of iNO and prostacyclins. 

    primary snippet moa ino
    # Epi 61 - ICU Primary Snippet 4- clot formation following vessel injury

    Play Episode Listen Later Jan 25, 2023 7:23


    In this epsiode, I discuss the events following vessel injury leading up to clot formation.

    injury primary formation vessel snippet clot
    # Epi 60 - ICU Primary Snippet 3 - Smooth muscle cell - Excitation- contraction coupling

    Play Episode Listen Later Jan 18, 2023 5:30


    In this episode, I discuss the physiology of smooth muscle cell contraction and how it differs from skeletal muscle cell contraction. 

    primary muscle smooth snippet contraction coupling excitation
    # Epi 59- ICU Primary Snippet 2 - Serum Creatinine and Creatinine Clearance

    Play Episode Listen Later Jan 11, 2023 8:17


    In this episode, I discuss the importance and limitations of Serum creatinine and creatinine clearance for renal function assessment.

    primary snippet serum clearance creatinine
    # Epi 58- ICU Primary Snippet 1 - Critical Illness and Pharmacokinetics

    Play Episode Listen Later Jan 5, 2023 11:29


    Wish you all a very happy 2023. From this episode, we will bring you the new series called Primary snippets, covering all difficult questions with less than a 50 % pass rate. The first snippet covers the impact of critical illness on pharmacokinetics.

    primary snippet critical illness pharmacokinetics
    # Epi 57 - ICU Primary - Bedside Preparation - Albumin, PRBC and Blood Grouping

    Play Episode Listen Later Sep 30, 2022 26:45


    Join us in this episode, where we discuss the pharmacology of IV albumin, PRBC, along with the process of blood grouping and cross-matching. 

    blood preparation iv primary bedside grouping albumin prbc
    # Epi 56 - ICU Primary - Bedside Preparation - Blood Thinning Agents

    Play Episode Listen Later Jul 17, 2022 30:46


    Join us as we discuss the pharmacology and pharmacokinetics of blood thinning agents commonly used in the Intensive Care setting.  Test yourself on our fun fact questions and more.

    blood preparation primary bedside intensive care thinning
    # Epi 55 - ICU Primary - Bedside preparation Part 12 - Renal Physiology

    Play Episode Listen Later Jun 21, 2022 24:08


    preparation primary physiology renal bedside
    #Epi 54 - ICU Primary - Bedside preparation Part 11 - Liver Physiology and pharmacology part 1

    Play Episode Listen Later May 23, 2022 25:58


    In this episode, we discuss the functions of the liver, hepatic blood flow and the role of the cytochrome system in drug metabolism in intensive care.

    preparation primary liver physiology pharmacology bedside
    #Epi 53 - ICU Primary - Bedside preparation Part 10 - Neuromuscular Blockade

    Play Episode Listen Later Apr 13, 2022 30:59


    In this episode, we discuss the physiology of neuromuscular junction, the pharmacology and the principles of neuromuscular monitoring.

    preparation primary blockades bedside neuromuscular
    #Epi 52 - ICU Primary - Bedside preparation Part 9 - Trauma Patient

    Play Episode Listen Later Mar 11, 2022 27:08


    In this episode, we discuss coagulation cascade, the principles behind ROTEM and the pharmacology of Tranexamic acid.

    trauma patients preparation primary bedside rotem tranexamic
    #Epi 51 - ICU Primary - Bedside preparation Part 8 - Elderly Patient

    Play Episode Listen Later Jan 22, 2022 24:43


    In this episode, we discuss the physiology and pharmacology relevant to an elderly patient admitted to the intensive care unit.

    patients preparation primary elderly bedside
    #Epi 50 - ICU Primary - Bedside preparation Part 7 - Christmas Special

    Play Episode Listen Later Dec 23, 2021 27:11


    In this episode, we discuss 1. How does thermoregulation work in Santa? 2. How does a thermometer work? 3. What are the physiological effects when Santa returns to the North Pole?

    santa preparation christmas special primary north pole bedside
    #Epi 49 - ICU Primary - Bedside preparation Part 6

    Play Episode Listen Later Dec 2, 2021 24:58


    In this episode, we continue to discuss how to prepare for primary exams at the bedside. We discuss carbohydrate metabolism, the pharmacology of TPN and the measurement of basal metabolic rate. 

    preparation primary bedside tpn
    #Epi 48 - ICU Primary - Bedside preparation Part 5

    Play Episode Listen Later Nov 2, 2021 18:49


    In this episode, we discuss the pharmacology of oxygen, the physics behind oxygen sensors in the ventilator and the mechanism of oxygen delivery. 

    preparation primary bedside
    #Epi 47 - ICU Primary - Bedside preparation Part 4

    Play Episode Listen Later Oct 2, 2021 30:02


    In this episode, we discuss the anatomy of brainstem reflexes along with the pharmacology of mannitol, phenytoin and levetiracetam.

    preparation primary bedside
    #Epi 46 - ICU Primary - Bedside preparation Part 3

    Play Episode Listen Later Sep 2, 2021 23:53


    In this episode, we discuss the modified Pomodoro technique for bedside Primary exam preparation. We examine the neurointensive care patient to discuss the anatomy of CSF production, Cerebral blood flow regulation and physics of ICP monitoring.

    preparation primary cerebral icp pomodoro bedside csf
    #Epi 45 - ICU Primary - Bedside preparation Part 2

    Play Episode Listen Later Aug 3, 2021 24:53


    In this episode, we discuss the modified Pomodoro technique to help Primary candidates prepare for their exams during daily bedside ward rounds. 3 questions were discussed in this episode - Pulse oximeter, Comparison between Noradrenaline and vasopressin, and physiological effects of hypoxia.

    comparison preparation primary pulse pomodoro bedside noradrenaline

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