Podcasts about svr

Vous aimez notre peau de caste ? Soutenez-nous ! https://www.lenouvelespritpublic.fr/abonnementUne émission de Philippe Meyer, enregistrée au studio l'Arrière-boutique le 12 juin 2026.Avec cette semaine :François Bujon de l'Estang, ambassadeur de France.Matthias Fekl, avocat et ancien ministre de l'Intérieur.Marc-Olivier Padis, directeur des études de la fondation Terra Nova.LA CAMPAGNE DE JEAN-LUC MÉLENCHONJean-Luc Mélenchon a choisi, le 7 juin, Saint-Denis pour donner le coup d'envoi de sa quatrième candidature à l'élection présidentielle, entre la basilique cathédrale où furent sacrés quelques-uns des premiers souverains du royaume, et en face de l'hôtel de ville conquis par le candidat LFI, Bally Bagayoko, dès le premier tour des élections municipales il y a trois mois.Jadis universaliste et jacobin, Jean-Luc Mélenchon a approfondi une mue politique engagée depuis plusieurs années : faire de la « Nouvelle France » le cœur de son projet et de sa coalition électorale. La France de 2026 n'est plus celle de 1958. La société a changé dans sa composition, dans la place qu'y occupent les femmes, dans son niveau d'éducation, dans ses structures familiales, dans son rapport au travail comme à l'autorité. Le slogan « on est chez nous », traditionnellement associé au Rassemblement national, a été repris par la foule nombreuse des militants et sympathisants LFI pour signifier non l'exclusion, mais l'appartenance commune à la République.Le rassemblement de Saint-Denis a montré un visage plus maîtrisé du leader insoumis, préférant la démonstration intellectuelle à la polémique permanente, le récit politique à l'invective. Jean-Luc Mélenchon s'est posé en un rassembleur apaisé, et leader à gauche. Sourire, discours resserré, dérapages évités, remisant ses provocations pour renfiler son costume de républicain, le candidat des insoumis à la présidentielle s'est contenté de lire son discours et d'égrener ses fondamentaux politiques : « smic à 1.700 euros » (soit 15 % de plus qu'actuellement), retraite à 60 ans, Sécurité sociale gérée par ses cotisants, règle du « chacun selon ses besoins ». Promettant de déclencher une « révolution citoyenne », de confier le pouvoir au peuple, de restreindre la propriété privée, de taxer les riches pour une meilleure répartition des richesses « entre le capital et le travail », il vise à mettre en œuvre un « projet qu'il définit lui-même comme collectiviste ». S'il est élu, la France quittera l'Otan, recherchera un accord avec la Russie et s'affranchira des règles européennes si elles l'entravent : « Nous décréterons un moratoire sur toutes les directives contraires aux mandats que nous aurons donnés notre peuple », a-t-il annoncé. Plutôt que de sortir de l'Union européenne, il propose « une Europe débarrassée du libéralisme ».Se posant en seul pôle politique clair à gauche, écrasant les socialistes et les verts, qui s'enferrent dans des débats internes illisibles, l'insoumis se place comme la seule alternative au RN. Agé de 74 ans, le tribun, bien que rejeté par 69 % de l'opinion (selon le baromètre mensuel Odoxa pour Public Sénat et la presse régionale), voit sa popularité grandir au sein de l'électorat de gauche, avec 49 % d'adhésion. Toutefois, si 58 % des 18-24 ans ont une opinion favorable de Mélenchon, le chiffre chute à 14 % pour les 50-64 ans.FORUM DE SAINT-PÉTERSBOURG ET ISOLEMENT DE LA RUSSIELe 3 juin, à l'ouverture du Forum économique international de Saint-Pétersbourg, la ville natale de Vladimir Poutine, des drones ukrainiens ont frappé une installation pétrolière et un site militaire à proximité. Les quelque 200 invités de 130 pays ont été accueillis avec un panache de fumée noire en arrière-plan. L'ancien colonel du SVR (les services de renseignements extérieurs), Andreï Bezroukov a vu dans cette attaque un motif de poursuite de l'affrontement. Selon lui, « la Russie restera en état de guerre, et nous devons apprendre à vivre avec pour au moins deux décennies, et cela va façonner deux générations ».Le rendez-vous pétersbourgeois, lancé en 1997 est devenu « international » en 2007. Considéré autrefois comme le « Davos russe », il a changé de visage depuis l'invasion de l'Ukraine. Cette édition a donné la place d'honneur aux Chinois et aux Saoudiens. Il a reçu une délégation économique nord-coréenne, des représentants talibans et quelques figures occidentales. La présence, pour la première fois depuis 2022, d'une délégation allemande et d'élus du parti d'extrême droite de l'AfD a été remarquée.Plus de quatre ans après le début de la guerre contre l'Ukraine, la Russie fait face à de multiples sanctions occidentales, à une inflation élevée, à des coûts d'emprunt prohibitifs et à des pénuries de main-d'œuvre, qui placent son économie dans une situation délicate. Alors que la situation sur le front est proche de l'impasse, l'Ukraine multiplie les frappes sur les dépôts, raffineries de pétrole et oléoducs russes pour priver Moscou de l'une de ses principales sources de revenus. Le PIB russe s'est contracté de 0,2% au cours des trois premiers mois de l'année, selon les statistiques officielles. C'est la première baisse trimestrielle en trois ans. L'Etat a affiché un déficit budgétaire de 80 milliards de dollars au cours des quatre premiers mois de 2026 - soit l'équivalent de 2,5% du PIB annuel et plus que ce qui était prévu pour l'ensemble de l'année. Toutefois, la Russie dispose de certains atouts. C'est l'un des pays développés les moins endettés au monde (environ 16% du PIB) et il dispose d'un fonds souverain d'environ 156 milliards d'euros. Ses exportations d'hydrocarbures connaissent une hausse conséquente depuis le début de la guerre au Moyen-Orient, qui a bouleversé les marchés énergétiques.Affecté par une popularité en berne et des pertes lourdes sur le front, Vladimir Poutine a minimisé, le 5 juin, les difficultés économiques auxquelles fait face son pays, préférant vanter sa « souveraineté » et ses partenariats avec les pays du Sud. Il a rejeté, l'idée d'une rencontre en tête-à-tête proposée la veille par son homologue ukrainien dans une lettre ouverte, tant qu'un accord final n'aura pas été négocié en amont pour mettre fin à la guerre en Ukraine.Le forum de Saint-Pétersbourg s'est terminé le 6 juin comme il avait commencé : sous une salve d'attaques de drones ukrainiens.Chaque semaine, Philippe Meyer anime une conversation d'analyse politique, argumentée et courtoise, sur des thèmes nationaux et internationaux liés à l'actualité. Pour en savoir plus : www.lenouvelespritpublic.frHébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

19. maijā Krievijas specdienests SVR paziņoja, ka no Latvijas teritorijas tiekot gatavots uzbrukums Krievijai. Atšķirībā no citām reizēm, kad no Krievijas nākuši šāda veida apvainojumi, šoreiz tas ir diezgan detalizēts, pieminētas pat piecas bāzes, no kurām it kā tikšot veikti triecieni. Turklāt vēstījuma izplatīšanā izmantoti dažādi līmeņi – arī diplomātiskie un politiskie. Krievijas pārstāvis to pašu atkārtojis no ANO tribīnes un par to runajis arī Vladimirs Putins, uzsverot, ka šādi soļi nepaliks bez atbildes. Vai Krievija meklē tā saukto casus belli jeb ieganstu karam vai arī šai informatīvā kara operācijai ir citi mērķi?Par to žurnālista Māra Antoneviča un Austrumeiropas politikas pētījumu centra pētnieka Mārča Baloža sarunā.“Aizsardzības līnija” ir “Latvijas Avīzes” raidieraksts, kas veltīts dažādiem drošības jautājumiem, tajā skaitā arī informatīvā kara tematikai."Mediju atbalsta fonda ieguldījums no Latvijas valsts budžeta līdzekļiem. Par raidieraksta saturu atbild "Latvijas Avīze"#SIF_MAF2026

Oceano Dunes at Pismo Beach is the only place in California where you can legally drive on the beach. For over 25 years, Jim Suty and Friends of Oceana Dunes have been fighting to keep it that way. Jimmy and Tyler sit down with Jim to talk about what’s happening now — and what’s been happening for a long time. This one covers a lot of ground. Jim walks through the history of the snowy plover fight that started around 2001, the dust pollution battle that took center stage around 2019–2020, and the new issue that’s surfaced after all of that: SVR (the State Vehicular Recreation Area that manages the dunes) never completed the Incidental Take Permit for the snowy plover that should have been finalized as part of the original mitigation. The ITP is the document that allows recreation to continue in habitat where an endangered species is present, provided land managers mitigate impact to acceptable levels. Without it, the dunes are exposed. And because SVR was always reacting to the next crisis — the next budget cut, the next complaint from the Coastal Commission, the next thing coming down from the state level — the ITP kept getting pushed down the priority list until it didn’t get done. Jimmy and Tyler dig into why this keeps happening — turnover in land manager leadership, no consistent long-term relationships with the local OHV community, a reactive management culture that never gets ahead of anything. The parallels to what Jimmy and Tyler see with El Dorado National Forest, Tahoe National Forest, and the Rubicon are everywhere. The dust fight is a good-news story worth hearing in full. During COVID, when the dunes were closed and no OHVs were running, Friends of Oceana Dunes commissioned studies that showed the dust particulate in the town of Oceano was not being caused by OHV activity on the dunes. The science that the APCD and the Coastal Commission had been using to justify closures and restrictions was wrong. Friends of Oceana Dunes fought it in court, won, and the APCD was ruled to have been incorrect — with money that had been spent on dust mitigation going back toward recreational purposes. Tyler and Jimmy hold this up as exactly what litigation looks like when it works. On where the money needs to come from: Tyler makes the argument that $20 to a litigation organization like Friends of Oceana Dunes or Blue Ribbon Coalition does more long-term work than $20 to a trail maintenance volunteer fund. Both matter. But if you can only pick one, he argues the scale is in favor of litigation. The numbers are striking — Jim mentions that 1.5 to 2.5 million people visit Oceana Dunes per year. If every one of them gave a quarter, Friends of Oceana Dunes would have a $500K–$750K operating budget. That’s how underfunded these organizations are relative to the scale of the impact they’re having. Also in this episode: the new California OHV certification bill being pushed by KORVA (which has passed its first stages of legislation), the “two knuckleheads” problem and why bad actors in OHV get more press than bad actors in every other outdoor recreation category, why the Coastal Commission tried to stop Friends of Oceana Dunes from picking up trash on the beach, the OHV super PAC joke that maybe wasn’t entirely a joke, and Jimmy’s personal note about his college memories at Pismo. Closing call to action: time, talent, or treasures. Find your carrot, find the organization working on it, and put something toward it. **Find Friends of Oceana Dunes:** Website: https://www.oceanodunes.org/Donate Today: https://www.paypal.com/donate?token=XpwAwnzV8dxTRn3lCzpU2W8PtfcpioHxik3tAvbkFMfOIHbNvXjXH22QILbpr6ixt8Xs15fStatskAR3Instagram: https://www.instagram.com/friendsofoceanodunes/Desert Fest: https://www.oceanodunes.org/2025/09/24/march-2026-dezertfest/ SnailTrail4x4 Discord: https://discord.gg/yFyFFkQbuyCome hang out with us on the SnailTrail4x4 Discord — it’s the easiest way to connect with Tyler and Jimmy directly, chat with fellow offroad enthusiasts, and get first access to Group Buys and Treasure Hunt token drops. MORRFlate Giveaway at 900 Reviews on Apple Podcast. But our next giveaway is when we reach 800 reviews; we are giving away an OnX Elite Membership. We will also give away an OnX Elite membership when we get to 850. However, when we reach 900 Reviews, we are teaming up with MORRFlate for a $1000 MF Product Giveaway. Go over to Apple Podcasts to leave your review now and become eligible to win. Congratulations to A13XMONT, who won a set of tires from Yokohama Tire! Call us and leave us a VOICEMAIL!!! We want to hear from you even more!!! You can call and say whatever you like! Ask a question, leave feedback, correct some information about welding, say how much you hate your Jeep, and wish you had a Toyota! We will air them all, live, on the podcast! +01-916-345-4744. If you have any negative feedback, you can call our negative feedback hotline, 408-800-5169. 4Wheel Underground has all the suspension parts you need to take your off-road rig from leaf springs to a performance suspension system. We just ordered our kits for Kermit and Samantha and are looking forward to getting them. The ordering process was quite simple, and after answering the questionnaire, we ensured we got the correct and best-fitting kits for our vehicles. If you want to level up your suspension game, check out 4Wheel Underground. SnailTrail4x4 Podcast is brought to you by all of our peeps over at irate4x4! Make sure to stop by and see all of the great perks you get for supporting SnailTrail4x4! Discount Codes, Monthly Give-Always, Gift Boxes, the SnailTrail4x4 Community, and the ST4x4 Treasure Hunt! Thank you to all of those who support us! We couldn’t do it without you guys (and gals!)! SnailSquad Monthly Giveaway This month’s giveaway is with Iceco Freezers. We are excited to work with and share their exciting new releases. One lucky winner has a chance to win. Big thanks to Iceco for sponsoring this month’s giveaway. If you want a chance to win, sign up for the Giveaway Tier on Irate4x4 Congrats to Johnny Freskie you won the Rusoh Fire Extinguishers. We have one of their 2.5-pound extinguishers to give away to a lucky winner. This extinguisher has an 18-year shelf life and is the best fire extinguisher for any off-road vehicle. To learn more, check out Rusoh.com. 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At the SOAP meeting in Montreal, Desiree Chappell and Monty Mythen interview Dr. Marie Louise Meng, Assistant Professor of Anesthesiology at Duke University Department of Anesthesiology and her former cardio-obstetric fellow Liliane Ernst, assistant professor in the Obstetric and Gynecologic Anesthesia section Wake Forest University. The conversation focuses on cardio-obstetric anesthesia, hemodynamics, monitoring, and patient-centered care. Meng describes building multidisciplinary "pregnancy heart teams" to plan management for complex cardiac disease in pregnancy and reduce birth trauma. Ernst discusses research using the Premier database on preexisting atrial fibrillation in pregnancy (about 25 per 100,000 deliveries) and associated management and outcomes. They review cases including mechanical circulatory support with an Impella to prolong pregnancy and highlight knowledge gaps about placental perfusion and pulsatility, including Fontan physiology. Meng outlines individualized hemodynamic monitoring for labor and C-sections, emphasizes recognizing hypertensive instability, and details preeclampsia with severe features, its end-organ criteria, incidence, disparities, postpartum follow-up challenges, and potential use of remote monitoring and noninvasive cardiac output/SVR monitoring to guide therapy. Monty Mythen, founding editor-in-chief of TopMedTalk, is now Senior Vice President, Scientific Liaison, BD Advanced Patient Monitoring. He is also Emeritus Professor of Anaesthesia and Critical Care, University College London, UK. Desirée Chappell, former co-editor-in-chief of TopMedTalk, is now Director of Medical Affairs and Medical Science Liaison, BD Advanced Patient Monitoring. She is also a CRNA at NorthStar Anesthesia, USA. -- Join us at Evidence Based Perioperative Medicine (EBPOM) World Congress 2026 in London. Be part of a global conversation as clinicians from around the world gather between 7-9th July at the British Library in London. Three days of evidence-based perioperative medicine, global insights, and expert debate—featuring speakers including Michael Marmot and Ken Rockwood. Register here - EBPOM World Congress 2026

Libsyn Podcast Distribution Description Episode 7b | Interest Rates: The 4 Types You Need to Know Thinking about applying for a mortgage but not sure which rate to choose? In this episode of On The Ladder, host Sarah Tucker and acting senior mortgage adviser Gemma Bennett walk you through the four most common mortgage rate types -  fixed, tracker, discount, and SVR. You'll learn how each rate works, how your monthly payments could be affected, and crucially, why landing on the SVR is something every first-time buyer should try to avoid. Gemma also explains why you should be talking to your adviser six months before your current rate ends. On The Ladder is an exclusive series created to help first-time buyers understand the mortgage process with confidence. Hosted by Sarah Tucker, CEO of The Mortgage Mum & broadcaster. Mortgage expertise from Gemma Bennett, Acting Senior Mortgage Adviser at The Mortgage Mum.

¿Todos los ácidos exfolian? ¿El retinol es solo paraarrugas? ¿El ácido hialurónico puede irritar la piel?En este episodio desmontamos mitos y te explicamos, de forma clara y práctica, cómo funcionan los principales ácidos en cosmética y cómo elegir el adecuado según tu piel.

Actif en Europe pour défendre les intérêts du Kremlin, le patriarcat de Moscou l'est aussi en Afrique, où l'Église orthodoxe russe se targue d'avoir considérablement accru son audience. Des fuites de documents provenant d'entités russes paraétatiques permettent de documenter le travail de sape entrepris contre l'église catholique en Afrique et l'autorité du pape.  L'alignement du patriarcat de Moscou de l'Église orthodoxe russe avec le Kremlin, notamment au sujet de la politique étrangère et de l'Ukraine, devient un élément-clé de l'influence russe dans le Sud Global. Le récent voyage du pape Léon XIV en Afrique a fait l'objet d'une véritable offensive de dénigrement relayée sur les comptes pro-russes des grandes plateformes, et notamment sur la chaîne Telegram  Rybar Africa, liée au ministère russe de la Défense. Des attaques ciblant les chrétiens non orthodoxes se sont multipliées, alimentées par tout un écosystème de médias numériques et autres, sous influence russe. Ces publications sont dans le droit fil des opérations d'influence documentées par l'organisation Impact-All Eyes on Wagner, sous le titre « SVR-controlled Politology labels non-orthodox christian groups as western agents to undermine the west in Africa ». On en parle avec Lou A-Osborn qui a participé au projet avec le consortium Forbidden Stories, Dossier Center, iStories et OpenDemocracy, ainsi que tout un réseau de journalistes russophones indépendants.    « L'officine Politologie africaine -contrôlée par le SVR, le renseignement extérieur russe- qualifie les groupes chrétiens non orthodoxes d'agents occidentaux, afin de saper l'influence de l'Occident en Afrique ». L'enquête publiée par Impact-All eyes on Wagner repose sur 1 431 pages de documents internes de « la Compagnie », qui désigne les entités de ce que l'on appelait la galaxie Prigozhine. On y trouve des documents comptables notamment, mais aussi -noir sur blanc- les narratifs artificiellement propagés et amplifiés sur les réseaux sociaux.  *** Pour faire le point sur la pratique du fact-checking et de la vérification de l'information en Afrique francophone, nous avons joint à Dakar  Boureima Salouka. Le journaliste burkinabè coordonne la Plateforme africaine des fact-checkers francophones (Paff). La rédaction de la Paff établit un état des lieux mitigé de cette discipline journalistique, soumise à l'évolution délétère de l'accès aux sources d'information, et à de multiples pressions de la part des plateformes et de certains bailleurs.  *** La chronique de Grégory Genevrier : Liban : la désinformation cible les pertes de l'armée israélienne.

Actif en Europe pour défendre les intérêts du Kremlin, le patriarcat de Moscou l'est aussi en Afrique, où l'Église orthodoxe russe se targue d'avoir considérablement accru son audience. Des fuites de documents provenant d'entités russes paraétatiques permettent de documenter le travail de sape entrepris contre l'église catholique en Afrique et l'autorité du pape.  L'alignement du patriarcat de Moscou de l'Église orthodoxe russe avec le Kremlin, notamment au sujet de la politique étrangère et de l'Ukraine, devient un élément-clé de l'influence russe dans le Sud Global. Le récent voyage du pape Léon XIV en Afrique a fait l'objet d'une véritable offensive de dénigrement relayée sur les comptes pro-russes des grandes plateformes, et notamment sur la chaîne Telegram  Rybar Africa, liée au ministère russe de la Défense. Des attaques ciblant les chrétiens non orthodoxes se sont multipliées, alimentées par tout un écosystème de médias numériques et autres, sous influence russe. Ces publications sont dans le droit fil des opérations d'influence documentées par l'organisation Impact-All Eyes on Wagner, sous le titre « SVR-controlled Politology labels non-orthodox christian groups as western agents to undermine the west in Africa ». On en parle avec Lou A-Osborn qui a participé au projet avec le consortium Forbidden Stories, Dossier Center, iStories et OpenDemocracy, ainsi que tout un réseau de journalistes russophones indépendants.    « L'officine Politologie africaine -contrôlée par le SVR, le renseignement extérieur russe- qualifie les groupes chrétiens non orthodoxes d'agents occidentaux, afin de saper l'influence de l'Occident en Afrique ». L'enquête publiée par Impact-All eyes on Wagner repose sur 1 431 pages de documents internes de « la Compagnie », qui désigne les entités de ce que l'on appelait la galaxie Prigozhine. On y trouve des documents comptables notamment, mais aussi -noir sur blanc- les narratifs artificiellement propagés et amplifiés sur les réseaux sociaux.  *** Pour faire le point sur la pratique du fact-checking et de la vérification de l'information en Afrique francophone, nous avons joint à Dakar  Boureima Salouka. Le journaliste burkinabè coordonne la Plateforme africaine des fact-checkers francophones (Paff). La rédaction de la Paff établit un état des lieux mitigé de cette discipline journalistique, soumise à l'évolution délétère de l'accès aux sources d'information, et à de multiples pressions de la part des plateformes et de certains bailleurs.  *** La chronique de Grégory Genevrier : Liban : la désinformation cible les pertes de l'armée israélienne.

En este episodio de A GUSTO EN MI PIEL by SVR hablamos de un tema fundamental: la fotoprotección infantil. ¿Por qué la piel del bebé es más vulnerable al sol? ¿Es cierto que los niños solo pueden usar filtros minerales? ¿Y qué diferencias reales hay entre filtros físicos, químicos, orgánicos e inorgánicos? Junto al dermatólogo pediátrico Raúl de Lucas y la dermatóloga especializada en cosmética Sara Gómez, repasamos cómo cambia la piel infantil durante los primeros años de vida, por qué no se recomienda la exposición solar directa en menores de seis meses y cómo elegir un protector solar adecuado sin caer en mitos o alarmismos. Además, hablamos de quemaduras solares en la infancia, riesgo futuro de cáncer de piel, cantidad y frecuencia de aplicación, vitamina D, contaminación urbana y del papel clave que tienen la educación solar y el ejemplo de los adultos en casa.

Unmask the shadowy world of Russian espionage in this lecture with Sean M. Wiswesser, a national security professional whose career spans nearly three decades across intelligence, foreign service, and defense institutions. Drawing on his experience as a senior operations officer with the Central Intelligence Agency—including multiple overseas tours, war-zone deployments, and service as a chief of station—Wiswesser offers a rare, insider perspective on the evolving landscape of global intelligence. Centering on the Russian Intelligence Services (RIS), this talk explores the doctrine of Maskirovka—the art of denial, deception, and manipulation that underpins Russian strategy. Through historical case studies and firsthand insights, Wiswesser examines the structure and operations of Russia's principal intelligence agencies: the SVR, GRU, and FSB. Topics include the use of double agents, surveillance and “street work,” honey traps, sabotage, active measures, assassinations, and the role of intelligence services in the Russo-Ukraine War. A Morehead Scholar at the University of North Carolina at Chapel Hill, Wiswesser holds a bachelor's degree in history and Russian & Slavic linguistics. He earned a Master of Strategic Studies from the Air War College in 2023, where he received the Russia Integrated Deterrence Award. Subscribe for more expert lectures and conversations at the forefront of global policy, strategy, and leadership. **Learn more about IWP graduate programs: https://www.iwp.edu/academics/graduate-degree-programs/ ***Make a gift to IWP: https://wl.donorperfect.net/weblink/WebLink.aspx?name=E231090&id=3

In this episode, Sean M. Wiswesser, former CIA Operations Officer, discusses his latest book, "Tradecraft, Tactics, and Dirty Tricks: Russian Intelligence and Putin's Secret War". The book explores the covert world of Russian espionage and how the Russian Intelligence Services (RIS) - the SVR, GRU, and FSB, including their use of double agents, surveillance, and “street work,” honeytraps, sabotage, active measures, assassinations - operate across the globe including the tactics, tradecraft, and mindset of the RIS. And the RIS roles in the Russo-Ukraine War. Interview date Wednesday, 25 March 2026. Interviewers Paul Hollingsworth PhD, former Senior CIA Officer and Analyst, President, AFIO, and Co-Host James Hughes, President Emeritus, AFIO.

En este episodio de A GUSTO EN MI PIEL by SVR hablamos de las pieles polialérgicas y reactivas: esas que pican, arden o se enrojecen “por todo” (cosméticos, clima, estrés, contaminación…). Con la alergóloga Paula Ribó explicamos cómo identificar una piel reactiva, qué ocurre cuando la barrera cutánea está alterada (la metáfora de la “pared de ladrillos”) y por qué existe una conexión real entre piel y cerebro. Además, aterrizamos recomendaciones prácticas: duchas cortas con agua templada, limpieza con productos respetuosos (mejor aceites/“syndets” que jabones agresivos), cómo actuar ante brotes y por qué la fotoprotección sigue siendo clave incluso en pieles sensibles. Cerramos con la sección de mitos: “si pica, funciona”, “soy alérgico a todo”, “solo agua” o “retinol prohibido”. Spoiler: tu piel no necesita sufrimiento para “hacer efecto”.

En el episodio de hoy hablamos de todo lo que necesitas saber sobre los cuidados diarios del bebé, desde el baño hasta la protección solar ☀️Comentamos si es necesario bañarlos todos los días, cómo hacer un baño adecuado y qué hacer después para cuidar su piel. También hablamos de hidratación, cuidado del pañal, uñas y pequeños problemas frecuentes como la dermatitis perioral.Además, repasamos básicos como el botiquín del recién nacido, higiene dental, vitaminas y resolvemos dudas muy comunes sobre el día a día con bebés.Terminamos con un tema clave: protección solar en bebés y niños y cómo hacerlo correctamente según la edad.Un episodio práctico, claro y lleno de consejos útiles para el día a día.Productos mencionados:Baño de Weleda recién nacido: https://www.farmaelglobo.com/bebe/3994-weleda-calendula-bano-bebe-buenas-noches-200-ml-3596200052705.htmlGel champú Weleda: https://www.farmaelglobo.com/productos-cuidado-corporal/3626-weleda-2-en-1-champu-y-gel-de-ducha-400-ml-4001638590297.htmlGel champú Farmacia el Globo: https://www.farmaelglobo.com/bebe/2875-bano-espuma-gel-champu-parabotica-400-ml.htmlCrema hidratante bebé Weleda: https://www.farmaelglobo.com/bebe/3629-weleda-calendula-leche-corporal-200ml-4001638096539.htmlAceite bebé Weleda: https://www.farmaelglobo.com/bebe/3633-weleda-calendula-aceite-para-bebe-200-ml-4001638096553.htmlSET DE Bienvenida Weleda: https://www.farmaelglobo.com/bebe/3628-weleda-regalo-bienvenida-bebe-8435743101554.htmlTermómetro Suavinex bañera: https://www.farmaelglobo.com/bebe/1655-termometro-para-el-bano-infantil-suavinex-8426420303996.htmlUñas pack de suavinex: https://www.farmaelglobo.com/bebe/1288-set-de-manicura-para-bebe-verde-agua-0m-suavinex-8426420070249.htmlCrema pañal Farmacia el Globo: https://www.farmaelglobo.com/bebe/2869-pasta-agua-parabotica-8424561001528.htmlBálsamo multiusos de Weleda: https://www.farmaelglobo.com/productos-cuidado-corporal/3625-weleda-balsamo-multiusos-25-g-4001638530248.htmlProtección solar Heliocare atopic: https://www.farmaelglobo.com/productos-cuidado-corporal/2409-heliocare-360-pediatrics-atopic-lotion-spray-spf-50-250-ml-8470001930170.htmlProtección solar facial Isdin: https://www.farmaelglobo.com/marcas/3482-isdin-fotoprotector-fusion-water-magic-pediatrics-1-frasco-50-ml.htmlProteccion solar familiar SVR: https://www.farmaelglobo.com/marcas/1397-sun-secure-lait-spf50-250ml-3662361001743.htmlDermatitis atópica Oleogel: https://www.farmaelglobo.com/productos-cuidado-corporal/743-syndet-emoliente-tendencia-atopica-farmacia-el-globo-8470009295790.htmlDermatitis atópica Crema corporal: https://www.farmaelglobo.com/productos-cuidado-corporal/744-emulsion-calmante-dermatitis-atopica-farmacia-el-globo-8470009250546.html 

Sean Wiswesser spent three decades in the U.S. intelligence community, much of it running operations against Russia for the CIA. His new book, Tradecraft, Tactics, and Dirty Tricks, dissects of how the FSB, SVR, and GRU actually do their work: dead drops, signal sites, surveillance detection routes, and the street tradecraft that protected agents like Aldrich Ames and Robert Hanssen for years. Wiswesser explains why Russian services keep returning to Cold War–era methods, breaks down the operational differences between the SVR and GRU, and assesses elite units like Alpha, Vympel, and Spetsnaz whose mythology often outpaces their record. He also charts the sharp escalation in Russian sabotage across Europe, the mafia-like culture driving increasingly reckless operations, and Moscow's use of AI-enhanced active measures to deepen division in Western democracies.Subscribe and share to stay ahead in the world of intelligence, global issues, and current affairs.Order Tradecraft, Tactics, and Dirty Tricks: https://www.usni.org/press/books/tradecraft-tactics-and-dirty-tricksConnect with Sean on LinkedIn: https://www.linkedin.com/in/sean-wiswesser-a86603133/Please share this episode using these linksAudio: https://pod.fo/e/3fb9a1YouTube: https://youtu.be/WI7IChkSNpsSupport Secrets and SpiesBecome a “Friend of the Podcast” on Patreon for £3/$4: https://www.patreon.com/SecretsAndSpiesBuy merchandise from our shop: https://www.redbubble.com/shop/ap/60934996Buy us a coffee: https://buymeacoffee.com/secretsandspiesSubscribe to our YouTube page: https://www.youtube.com/channel/UCDVB23lrHr3KFeXq4VU36dgFor more information about the podcast, check out our website: https://secretsandspiespodcast.comConnect with us on social media Bluesky: https://bsky.app/profile/secretsandspies.bsky.socialInstagram: https://instagram.com/secretsandspiesFacebook: https://facebook.com/secretsandspiesSpoutible: https://spoutible.com/SecretsAndSpiesFollow Chris and Matt on Bluesky:https://bsky.app/profile/chriscarrfilm.bsky.socialhttps://bsky.app/profile/mattfulton.netSecrets and Spies is produced by Films & Podcasts LTD: https://filmsandpodcasts.co.uk/Music by Andrew R. BirdPhoto by Dmitry Astakhov / REXSecrets and Spies sits at the intersection of intelligence, covert action, real-world espionage, and broader geopolitics in a way that is digestible but serious. Hosted by filmmaker Chris Carr and writer Matt Fulton, each episode examines the very topics that real intelligence officers and analysts consider on a daily basis through the lens of global events and geopolitics, featuring expert insights from former spies, authors, and journalists.

Waarom kiezen steeds meer mensen weer voor kleinschalig kamperen? En wat maakt kamperen bij de boer juist nu zo aantrekkelijk? In deze aflevering van LeisureTalk spreekt host Richard Otten met Christel van Mill, voorzitter van de Stichting Vrije Recreatie. Vanuit de plek waar het allemaal begon, hoor je het verhaal achter SVR en de ontwikkeling van kamperen bij de boer. Het gesprek gaat over de oorsprong van SVR, de kracht van kleinschaligheid en de groei van de doelgroep. Van rust en ruimte tot nieuwe generaties kampeerders en de opkomst van verhuuraccommodaties. Ook komt het platform Huren bij de Boer aan bod en de rol van community binnen de sector. Voor wie is deze aflevering interessant • Eigenaren van campings en boerencampings • Ondernemers in recreatie en plattelandstoerisme • Beleidsmakers in toerisme en agrarische sector • Marketing- en platformontwikkelaars in leisure • Kampeerliefhebbers en recreatieprofessionals Wat je hoort in deze aflevering • Hoe SVR ontstond en uitgroeide tot netwerk van 2000 campings • Waarom kleinschalig kamperen weer populair is • De rol van donateurs en community binnen SVR • Groei van verhuuraccommodaties en het platform Huren bij de Boer • Trends zoals vaker op vakantie en het hele jaar door kamperen “Rust, ruimte en persoonlijk contact blijven de kern van kamperen bij de boer.” Over LeisureTalk Wil je meer weten over ons en wat we doen in de wereld van leisure, recreatie, toerisme en vrije tijd? Bekijk dan de website: www.leisuretalk.nl. Volg ons ook op LinkedIn of stuur ons een mail. LeisureTalk is dé podcast over toerisme, recreatie en vrije tijd. Elke aflevering gaan we de diepte in met een bijzondere gast. We ontleden trends, bespreken ontwikkelingen en onderzoeken ondernemerslessen. LeisureTalk bezorgt je een uniek perspectief op ons vakgebied. LeisureTalk.nl kan niet gemaakt worden zonder de steun van onze partners: LeisureTalk.nl kan niet gemaakt worden zonder de steun van onze partners: Ginder Ginder is een bureau dat werkt aan een vrijetijdseconomie die bijdraagt aan sterke steden en dorpen. Ze helpen overheden en organisaties bij complexe ruimtelijke vraagstukken rondom recreatie, toerisme en leefomgeving, met oog voor de plek én de mensen die er gebruik van maken. HISWA-RECRON HISWA-RECRON is de branchevereniging voor ondernemers in watersport, recreatie en toerisme. Ze ondersteunen ondernemers met kennis, belangenbehartiging en praktische ondersteuning, zodat zij hun bedrijf toekomstbestendig kunnen ontwikkelen. Eijsink Eijsink is leverancier van producten en oplossingen voor campings, vakantieparken en andere recreatiebedrijven. Met een breed assortiment en kennis van de sector helpen zij ondernemers bij het verbeteren van gastcomfort en dagelijkse bedrijfsvoering. Camping Comfort Camping Comfort ontwikkelt en levert praktische voorzieningen voor campings en vakantieparken. Hun oplossingen zijn gericht op comfort, gebruiksgemak en duurzaamheid, met als doel het verblijf van gasten zo prettig mogelijk te maken. Qenner Qenner ontwikkelt technische oplossingen en producten voor de recreatiemarkt. Ze richten zich op slimme, betrouwbare toepassingen die recreatieondernemers ondersteunen in hun dagelijkse praktijk en bijdragen aan een betere gastbeleving. Productie: Tessa Langedijk Montage: Menno Warnaar (Fime Productions) Muziek: MOJO by tubebackr — Creative Commons — CC BY-ND 3.0 Free Download / Stream: Audio Library

Today on Black Dragon Biker TVSegment 1: Pagans Member Admits Role in Assault of Rival Gang Members at West Norriton WawaOn March 23, 2026, Jason William Lawless, 46, a patched member of the Pagans Outlaw Motorcycle Gang from Bridgeport, PA, pleaded guilty in Montgomery County Court to simple assault and conspiracy to commit simple assault.This stems from the October 17, 2025, incident in the parking lot of the Wawa at 2544 West Main Street in West Norriton Township. Lawless and eight other Pagans allegedly rolled up on two members of the rival Unknown Bikers Outlaw Motorcycle Gang, surrounded them, and tried to rip off their colors. The confrontation turned into a shootout — six people were shot, including two innocent bystanders (one took a round to the face while putting air in his tires). Fourteen shell casings were recovered.Lawless is the first of the nine charged Pagans to take a plea. The rest are still facing serious felony charges including aggravated assault, riot, and recklessly endangering other persons. Classic colors dispute that went south fast and dragged civilians into it.Segment 2: SVR's Shadow Looms Over Founder of Night Wolves Biker Gang's Trip to ChinaFresh intelligence report dropped today: Alexander Zaldostanov (aka “The Surgeon” / Khirurg), longtime president and founder of Russia's Night Wolves Motorcycle Club, visited Fudan University in Shanghai in late February 2026. He spoke to Chinese students.What makes it interesting — he wasn't traveling light. He was accompanied by two individuals with known ties to Russia's SVR (Foreign Intelligence Service).The Night Wolves have long been viewed as a Kremlin soft-power/propaganda arm — they helped in Crimea in 2014, do the big “Roads of Victory” runs, and Zaldostanov has been tight with Putin for years. This China trip looks like another layer: using the club for influence work and plausible-deniability outreach while Russia and China keep tightening their strategic partnership.When outlaw-style clubs start moving with intelligence officers on foreign soil, it's no longer just about bikes and brotherhood.Segment 3: Ohio Queer Motorcycle Club Responds to Anti-LGBTQ+ Laws by Teaching How to Fire GunsIn Ohio, the Cleveland chapter of Queers on Gears (an LGBTQ+ motorcycle club) has been quietly running firearm training days. They hold classes in a barn on a family farm in Elyria, with transgender instructors teaching safe gun handling to queer students.The club says the rise in anti-LGBTQ+ legislation and rhetoric in Ohio pushed them to create a safe space for community self-defense training. They frame it as a natural fit with motorcycle culture's overlap with firearms. Spent casings on the floor, smiles on faces, and people learning the basics.This one sits at the intersection of identity, politics, and Second Amendment rights — something we don't see every day in the biker world.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-dragon-s-lair-motorcycle-chaos--3267493/support.Sponsor the channel by signing up for our channel memberships. You can also support us by signing up for our podcast channel membership for $9.99 per month, where 100% of the membership price goes directly to us at https://www.spreaker.com/podcast/the-.... Follow us on:Instagram: BlackDragonBikerTV TikTok: BlackDragonBikertv Twitter: jbunchiiFacebook: BlackDragonBikerBuy Black Dragon Merchandise, Mugs, Hats, T-Shirts Books: https://blackdragonsgear.comDonate to our cause:Cashapp: $BikerPrezPayPal: jbunchii Zelle: jbunchii@aol.com Patreon: https://www.patreon.com/BlackDragonNPSubscribe to our new discord server https://discord.gg/dshaTSTSubscribe to our online news magazine www.bikerliberty.comGet 20% off Gothic biker rings by using my special discount code: blackdragon go to http://gthic.com?aff=147Join my News Letter to get the latest in MC protocol, biker club content, and my best picks for every day carry. https://johns-newsletter-43af29.beehi... Get my Audio Book Prospect's Bible an Audible: https://adbl.co/3OBsfl5Help us get to 30,000 subscribers on www.instagram.com/BlackDragonBikerTV on Instagram. Thank you!We at Black Dragon Biker TV are dedicated to bringing you the latest news, updates, and analysis from the world of bikers and motorcycle clubs. Our content is created for news reporting, commentary, and discussion purposes. Under Section 107 of the Copyright

We discuss the diagnosis and treatment of one of EM's paradoxes: High-Output Heart Failure. Hosts: Nicolas Gonzalez, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/HOHF.mp3 Download Leave a Comment Tags: Cardiology Show Notes Core EM Modular CME Course Maximize your commute with the new Core EM Modular CME Course, featuring the most essential content distilled from our top-rated podcast episodes. This course offers 12 audio-based modules packed with pearls! Information and link below.  Course Highlights: Credit: 12.5 AMA PRA Category 1 Credits™ Curriculum: Comprehensive coverage of Core Emergency Medicine,  with 12 modules spanning from Critical Care to Pediatrics. Cost: Free for NYU Learners $250 for Non-NYU Learners Click Here to Register and Begin Module 1 1. Core Definition & Hemodynamic Profile Clinical Paradox: Congestive symptoms (pulmonary edema, JVD, peripheral edema) in the setting of a hyperdynamic, supranormal cardiac function. Hemodynamic Criteria: Cardiac Index (CI): >4.0 L/min/m2. Cardiac Output (CO): >8 L/min. Systemic Vascular Resistance (SVR): Pathologically low (vasodilated or shunted state). The “Warm” Phenotype: Unlike standard HFrEF/HFpEF (often “Cold and Wet”), HOHF presents as “Warm and Wet” due to low SVR and bounding pulses. 2. Pathophysiology: The Hemodynamic Paradox Primary Insult: Decreased SVR (either via peripheral vasodilation or arteriovenous shunting). Effective Arterial Blood Volume: Paradoxically low despite high total CO. Neurohormonal Cascade: Activation of Renin-Angiotensin-Aldosterone System (RAAS). Increased Sympathetic Nervous System tone. Increased Antidiuretic Hormone (ADH) secretion. Resultant State: Avid renal salt and water retention leading to massive plasma volume expansion. Cardiac Response: Chronic volume overload → eccentric remodeling → chamber dilation → eventual secondary myocardial failure/dilated cardiomyopathy. 3. Differential Diagnosis: Etiological “Buckets” Category A: Increased Metabolic Demand (Systemic) Hyperthyroidism/Thyrotoxicosis: Direct T3 effects: increased chronotropy/inotropy. Indirect effects: metabolic byproduct accumulation causing peripheral vasodilation. Myeloproliferative Disorders: High cell turnover and increased oxygen consumption drive compensatory CO increase. Sepsis (Hyperdynamic Phase): Cytokine-mediated global vasodilation. Note: Often transient; may transition to sepsis-induced myocardial depression. Category B: Peripheral Vascular Effects (Shunting/Vasodilation) Arteriovenous Fistulas (AVF) / Malformations (AVM): Most Common Cause: Iatrogenic AVF for Hemodialysis (ESRD population). Bypasses high-resistance capillary beds, dumping arterial blood directly into venous circulation. Chronic Liver Disease (Cirrhosis): Formation of “spider angiomata” and internal AV shunts. Impaired clearance of endogenous vasodilators (e.g., Nitric Oxide). Thiamine Deficiency (Wet Beriberi): Accumulation of pyruvate/lactate → systemic vasodilation. Histopathology: Vacuolation, myofiber hypertrophy, and interstitial edema. Chronic Lung Disease: Hypoxia/Hypercapnia-driven systemic vasodilation. Concomitant pulmonary HTN (RV remodeling) but preserved/high LV output. Others: Paget's disease of bone (extensive micro-shunting), Carcinoid syndrome, Mitochondrial diseases, Acromegaly, Erythroderma. 4. Special Focus: Hemodialysis Access-Induced HOHF Physiologic Phases of AVF Creation: Acute Phase: Immediate ↓ SVR. ↑ Stroke volume and Heart Rate (SNS-mediated). Endothelial shear stress → Nitric Oxide release → further arterial dilation. Subacute Phase (Days to 2 Weeks): RAAS-driven volume expansion. ↑ Right Atrial, Pulmonary Artery, and LV End-Diastolic Pressures (LVEDP). Natriuretic peptide surge (BNP/ANP) peaks around Day 10. Chronic Phase (Weeks to Months): Adaptive hypertrophy. Decompensation occurs when dilation exceeds contractility limits. 5. Point-of-Care Physical Exam & Maneuvers Nicoladoni-Branham Sign (Pathognomonic for Shunt-driven HOHF): Maneuver: Manually compress the AVF (or inflate cuff to >50 mmHg above SBP) for 30 seconds. Positive Result: Reflexive bradycardia or a transient rise in systemic BP. Significance: Confirms the shunt is a major contributor to the cardiac workload. Peripheral Pulse Assessment: Water Hammer Pulses: Rapid upstroke and collapse. Quincke's Pulse: Visible capillary pulsations in the nail beds. Traube's Sign: “Pistol-shot” sounds auscultated over the femoral arteries. Volume Status: Rales, S3 gallop, peripheral edema (standard HF signs). 6. Diagnostic Workup (Technical Targets) POCUS / Echocardiography: Left Ventricle: Hyperdynamic function; EF typically >60%. Left Atrium: Significant dilation (Left Atrial Volume Index >34 mL/m2; Case study noted 72 mL/m2). IVC: Plethoric with minimal respiratory variation. Doppler: High flow velocities across the AV access if applicable. Laboratory Evaluation: BNP/NT-proBNP: Often markedly elevated (e.g., >70,000 in severe cases), though mean values in literature hover around 700–800 pg/mL. Hematology: CBC to evaluate for severe anemia (trigger for HOHF if Hgb7–8 g/dL to reduce demand. Beriberi: High-dose IV Thiamine (100–500 mg). Thyrotoxicosis: Beta-blockers (Propranolol) + Antithyroid meds (PTU/Methimazole). Phase 3: Surgical/Interventional Salvage (Refractory AVF Cases) Closure of Accessory Sites: If multiple fistulas exist, close the non-dominant/unused sites. Flow Reduction (Banding): Surgical narrowing of the fistula to target flow

Dr Deb Muth 00:03Well, welcome back to Let’s Talk Wellness Now. I am your host, Dr. Deb. And what is the most talked-about peptides in functional medicine? aren’t actually FDA approved. Not because they don’t work, but because no one’s funded the research to prove it yet. The truth is, some of the compounds that dominate wellness forums, BPC-157, TB-500, thymosin beta-4, epitalin, occupy a fascinating space between breakthrough science and unregulated experimentation. In today’s episode, we’re stepping into that grey zone, the world of investigational peptides, to separate mechanism from marketing. I’m going to walk you through the science that actually shows and where it stops, how to evaluate claims when human data don’t yet exist, and the quality, purity, and safety red flags that you need to recognise. Dr Deb Muth 01:06I created it in a previous episode, so go check that one out. And why honesty is the most important prescription in peptide medicine. If you’ve ever wondered whether these research-only peptides are the frontier of healing or the next functional medicine fad, this episode is for you. So grab your cup of tea or coffee, get comfortable, and let’s talk about what it really means to use peptides that are promising but still under investigation. So we’re going to break just for a second here and have a word from our sponsor. It is because of them that we stay on the air. So thank you for this. And we will be right back. Did you know sweating can literally heal your cells? Infrared saunas don’t just relax you. They detox your body, balance hormones, and boost mitochondrial energy. I’m obsessed with my Health Tech sauna. And right now, you can save $500 with my code at healthtechhealth.com slash dr-muth-req-25. Dr. Deb Muth 02:15All right, guys, welcome back. Let’s dive into investigational peptides, the evidence gap. So the following peptides we’re about ready to discuss are extensively in integrative, functional, and regenerative medicine circles. They may have intriguing mechanisms and promising preclinical data. However, they lack FDA approval, and the evidence quality varies dramatically. from interesting preliminary research to essentially no human data at all. And this distinction is really critical for maintaining scientific integrity. So let’s talk about immune-modulating peptides. There’s thymus and alpha-1, and this is an international story on the thymic peptides. Thymusin alpha-1, known as TA1, is marketed internationally as zidaxin. Dr. Deb Muth 03:16It’s a 28-amino acid polypeptide originally isolated from thymusin fraction 5, which was extracted from bovine thymus tissue. Modern production uses synthetic peptide synthesis. The thymus gland is located behind the sternum and is the primary site for T cell maturation, and thymic peptides like TA1 play roles in human system development and regulation. Now, I love thymus peptides. I love thymus glandular products. I’ve used thymus glandular products for decades. Ground-up animal thymus gland is basically what it is. There are a couple of different supplement companies that I’ve used over the years that are amazing with this. And they do a fantastic job, and they really do help to support the immune system. So when thymus peptides came out, it was really exciting because it took the whole idea of thymus support to a new level. Dr. Deb Muth 04:17The mechanism actually behind the thymus in alpha-1 is complex and involves multiple aspects of immune function. At the cellular level, TA1 enhances T cell maturation and differentiation, particularly the development of helper T cells and cytotoxic T cells. It modulates T cell receptor expression and can influence the balance between Th1 cell-mediated immunity and Th2 humoral immunity responses. And it also enhances the natural killer cell activity and modulates dendritic cell function, which are critical for antigen presentation. and initiation of adaptive immune responses. And on the cytokine level, TA1 influences production of interleukin-2, IL-2, interferon gamma, IFN-γ, and interleukin-10, IL-10. Dr. Deb Muth 05:19These create immune modulatory rather than simple immune stimulatory effects. This is a very important distinction because TA1 appears to help balance the immune system rather than simply ramping this up, which theoretically makes it safer in conditions where immune overstimulation would be a problem, such as an autoimmune disease. Hashimoto’s, autoimmune, lupus, Sjogren’s, any of those autoimmune diseases, we don’t want to overstimulate their immune system. So you want to use a product like this that’s non-stimulating. Now, the regulatory status on TA1 is geographically variable and represents one of the challenges in discussing this peptide with patients. It is not FDA-approved in the United States. However, it is approved in several other countries for specific conditions. Dr. Deb Muth 06:19In Italy, it’s approved for the treatment of chronic hepatitis B and hepatitis C. In China, it’s approved for chronic hepatitis B and adjunct immune compromised patients receiving vaccinations or suffering from certain infections. It has an orphan drug designation in the United States for certain cancer indications, but its designation does not constitute approval. It simply provides regulatory incentives for further development. So the evidence base for thymosin alpha-1 is substantial in some areas but comes primarily from non-US populations and research groups, which creates challenges in evaluating quality and generalizable information. So in hepatitis B and C, multiple clinical trials, many conducted in China and Italy, have examined TA1 as an adjunct to antiviral therapy. Dr. Deb Muth 07:21A meta-analysis by Wu and colleagues published in the Journal of Viral Hepatitis in 2013 examined 23 randomized controlled trials, including over 2,000 patients with chronic hepatitis B. The analysis found that combining TA1 with nucleoside analogs like LAMVDUDE or an and TCAVAR improved the hepatitis antigen seroconversion rates by HBV DNA clearance compared to its nucleoside analogs alone. And the effect sizes were modest but statistically significant, with the HBE-AG seroconversion rates improving from about 24% with antivirals alone to 38% in combined therapy. Now in hepatitis C, early trials before the development of direct-acting antivirals showed that TA1 combined with interferon alpha improved sustained virological responses, and compared to interferon alpha, Dr. Deb Muth 08:30Furon alone, particularly in difficult-to-treat populations like those with a genotype one or a high viral load. However, the advent of highly effective direct acting antivirals that achieve SRV rates, sorry, SVR rates exceeding 95%, the role of TA1 in hepatitis C has become less clear. Now in sepsis and critical illness, more recent interest has focused on TA1 in severe cases of sepsis and septic shock. Ren and colleagues published a systematic review and meta-analysis in the Frontiers of Immunology in 2022, analyzing 18 randomized controlled trials, including 1787 patients with severe sepsis or septic shock the pooled analysis showed that ta1 administration was associated with reduced 28-day mortality relative risk at 0.70 meaning a 30 reduction in mortality compared to the standard care alone and the effect appeared Dr. Deb Muth 09:39most pronounced in patients with sepsis-induced immunosuppression measured by HLA-DR expression in monocytes. Now, this is amazing because going forward, we’re going to talk about something that’s commonly known as cytokine storm. Now, cytokine storm really became apparent since 2020 with the viral infection that we’re dealing with in the world today. But they were already looking at this kind of cytokine storm produced by sepsis or sepsis-induced immunosuppression. And it triggered this hyperinflammatory response called the cytokine storm. And many patients who survived the initial phase of the immune suppressed stata, characterized by a T cell exhaustion, reduced antigen presentation, and increased susceptibility to secondary infections. Thymusin alpha-1, TA1, may help restore this immune competence in this phase. However, it’s important to note that patient selection and timing are critical. Dr. Deb Muth 10:43Giving this immune stimulant during a hyperinflammatory phase could theoretically worsen outcomes. So you don’t want to give it to them while they’re in the flare up or the sepsis or the infection, but given to them during the immunosuppression phase afterwards might be beneficial. Now there is also some cancer immunotherapy that we see with TA1 and has been studied as an adjunct in cancer treatment with the hypothesis that it could enhance immune surveillance and response to tumors. And a comprehensive review of Garci and colleagues published in Expert Opinion on Biological Therapy in 2007 examined multiple trials in melanoma, lung cancer, hepatocellular carcinoma, and other malignancies. And the results were mixed. Some trials showed improvement in the immune parameters, increased CD4 in T-cells. improved lymphocyte proliferation responses and some actually showed trends toward improved progression free survival but overall survival benefits were inconsistent and the heterogeneity of the cancer types treatment protocols and outcome measures makes a definitive conclusion difficult as a vaccine adjunct several studies particularly from china have examined ta1 as an adjunct to enhance vaccine responses Dr. Deb Muth 12:11in immune-compromised populations, including the elderly, dialysis patients, and transplant recipients. The rationale is sound. These populations often mount suboptimal antibody responses to vaccines, and TA1’s immune-enhancing effects might improve protection. There are small trials. They have shown improvement in seroconversion rates of hepatitis B vaccines and influenza vaccine in these populations. And though large-scale confirmatory studies are limited, there is a possibility here. Now, on their safety profile, one of the appealing aspects of thymusin alpha-A TA1 is that it’s apparently favorable safety profile in clinical trials. There are some injection site reactions with a little redness, a mild discomfort, and most commonly reported adverse effects. is that their severe adverse events attributable to TA1 have been rare in published trials. However, comprehensive long-term safety data are limited Dr. Deb Muth 13:13And theoretically, concern exists that immune modulation could potentially trigger or exasperate autoimmune conditions in susceptible individuals. Though this hasn’t been clearly demonstrated in clinical trials, integrative medicine considerations for integrative practitioners concerning the thymus and alpha-1, several factors require careful thought. First, sourcing and quality control are critical concerns. Since it’s not FDA approved, TA1 available in the United States typically will come from a compounding pharmacy or an international supplier with variable quality assurance. And pharmaceutical grade product with certificates of analysis showing purity, sterility, and endotoxin testing is essential, but it is readily available from many of these companies. Second, patient selection matters immensely. TA1 should be considered in complex cases where conventional approaches have been insufficient, such as chronic viral infections not responding adequately Dr. Deb Muth 14:21to standard antivirals, post-viral syndromes with evidence of immune dysfunction, cancer patients with immune suppression in consultation with oncology, and it should generally be avoided in active autoimmune disease unless there’s a compelling rationale and close monitoring. Now, TA1 is not a standalone therapy. In cases of chronic viral infection, Comprehensive immune support includes addressing nutritional deficiencies, optimizing vitamin D levels to be between 50 and 80, adequate zinc, selenium, and vitamin A, optimizing gut health since 80% of our immune function is in the gut, you need to optimize gut function. Managing stress from the HPA access dysfunction, chronic cortisol elevation, suppression, and immunity, ensuring adequate sleep, immune memory consolidations during sleep, addressing any metabolic dysfunction, insulin resistance, repairs in the immune function, and the bottom line on thymus and alpha-1 is Dr. Deb Muth 15:26is that it represents legitimate medicine in other countries with a substantial evidence base in specific contexts, but it remains experimental in the U.S., and practitioners using it should provide comprehensive, informed consent about its regulatory status, evidence quality, and source verification. while ensuring it’s part of comprehensive protocols. It is not a magic bullet. And again, what you’re gonna hear me say quite often here is that many of these peptides should be used in conjunction with something else. They should not be used alone. And can peptides be stacked? The answer is yes, they can. So if somebody has an insulin resistance, or a metabolic dysfunction, they can tier TA1 with a GLP-1 like terzepatide or semiglutide. That is not a problem to do that. You need to just work with a practitioner that understands how to do that effectively. So let’s look at BPC-157. Dr. Deb Muth 16:26This is a phenomenon I love BPC-157. Let’s separate it from marketing to actual mechanism of actions here. So BPC-157 stands for Body Protection Compound 157. It is a chain of 15 amino acids that are described as a partial sequence of body protection compound, a protein found in human gastric juice. It has become one of the most hyped peptides in regenerative medicine inside the athletic performance and biohacking communities with claims ranging from healing tendons and ligaments to repairing gut lining or reversing organ damage. The challenge is separating the legitimate mechanisms of science from the marketing hype. The proposed mechanism of BPC-157 are biologically plausible and intriguing. The research suggests that it may influence several growth factor pathways, including vascular endothelial growth factor, VEGF, which promotes new blood vessel formation and has improved better supply of blood flow to injured tissues, theoretically accelerating healing. Dr. Deb Muth 17:40It may also affect fibrous blast growth factor, FGF, and transforming growth factor beta, TGF beta pathways. both involved in tissue repair and remodeling. And some studies actually suggest that BPC-157 modulates inflammatory cascades, potentially reducing excessive inflammation while promoting the resolution phase that allows tissue rebuilding. Now I want to talk just a few moments here about these different tests that we’re talking about tgf beta veg f for those of you who are in our mold world you are very familiar with these uh lab tests we do this to see if you have a mold exposure what’s happening to your body and it’s been very challenging to try to heal this part of the mold illness and manipulate these VEGFs and TGF betas. And so with the fact that BPC helps us modulate this inflammatory cascade, BPC can be very helpful in the world of mold or mycotoxin illness in repairing those parts of the body that have been damaged by the mycotoxins. Dr. Deb Muth 18:48Now there is animal research on BPC-157. It is extensive and primarily from a research group led by pre-drag, oh, I can never say these names, Cyrek at the University of Zagreb in Croatia. Published studies in animal models have shown accelerated healing in a remarkable variety of injury types. A 2011 paper by Chang and colleagues in the Journal of Applied Physiology demonstrated that BPC-157 improved therapy tendon healing in rats with Achilles tendon injuries, and the treated rats showed increased tendon outgrowth, better cell survival in the injured area, enhanced cell migration to the injury site, and improved biochemical strength of the healed tendon compared to controls. Multiple other animal studies have shown similar promising effects. Ligament tears, healing faster in rabbits, muscle damage recovering more quickly in rodent models, gastric ulcers healing in rats given experimental induced ulcerations, inflammatory bowel lesions improving in mouse models of colitis, and even bone to tendon healing showing enhancement in animal studies. Dr. Deb Muth 20:02The breadth of injury types showing benefit in preclinical models explains the enthusiasm of this peptide. However, this is critical. These animal studies, primarily in rodents and rabbits, animal models of injury healing don’t reliably translate to human clinical outcomes. And the doses used in these animal studies when converted to human equivalent doses vary widely. And optimal human dosing is completely unknown at this point. it is all considered experimental and perhaps most importantly there are essentially no peer-reviewed controlled clinical trials in human published in humans published in major medical journals in a 2001 review of arthroscopy and the journal of arthroscopic and related surgery specifically examined in the evidence of bpc 157 and other peptides in musculoskeletal medicine The authors concluded bluntly that BPC-157 lacks evidence from randomized controlled trials and has an unknown safety profile in humans. Dr. Deb Muth 21:09 They emphasized that the jump from animal data to recommending peptides for humans use bypasses the fundamental requirement for Phase I safety studies, Phase II dose-finding studies, and Phase III efficacy trials that would establish whether BPC-157 actually works in humans and whether or not it’s safe. The absence of human safety data is particularly concerning given BPC-157’s proposed mechanisms. Peptides that influence growth factor signaling and angiogenesis could theoretically have off-target effects. Uncontrolled angiogenesis, for instance, is a hallmark of cancer progression. Tumors require blood vessel formation to grow beyond a certain size. And while there’s no evidence that BPC 157 promotes cancer, The complete absence of long term human safety studies means we simply don’t know. This isn’t fear mongering. It’s acknowledging uncertainty and uncertainty exists and understanding that if you’re choosing to use peptides like BPC 157, you are doing it in an experimental model. Dr. Deb Muth 22:17We’re experimenting with the doses that are being used. And there is potential for it to cause cancer cells in your body to grow. And you need to be aware of this and understand the risks that you’re taking when you’re using an investigational or off label use peptide. Now, quality control issues with BPC also exist. It’s not FDA approved for any indication in the US. It’s not approved in any major regulatory jurisdiction worldwide. It’s marketed as a research chemical explicitly to bypass FDA oversight. And commercial sources selling BPC-157 range from compounding pharmacies, which have some quality standards but are not FDA inspected. You can take that for what you want to believe on that one. to overseas suppliers operating with absolutely no quality assurance whatsoever. If you are choosing to use BPC-157, you have to understand who’s manufacturing it for you, where you are getting it from, how pure it is. Dr. Deb Muth 23:26You want to make sure that you have the certificate of analysis and that it does not contain bacterial endotoxins that can contaminate the peptide or degrade the peptide and cause other issues for you. So when you talk about peptides with patients regarding BPC-157 or if you’re listening to this and you’re already using BPC-157 or other peptides, that are quote-unquote not for human consumption, an evidence-based response acknowledges both the appeal and the limitations. And you want to talk about the animal data that’s definitely showing some progress and some potential, but we don’t know what we don’t know in humans. If people are willing to take that risk, that is up to them to do that. But using BPC right now is experimental and people need to be aware of that. Are there evidence-based alternatives for patients with tendon or ligament injuries? Dr. Deb Muth 24:26And there are. There’s PRP, which has been studied in multiple randomized controlled trials. for conditions like lateral epicondylitis, tennis elbow, Achilles issues, patellar issues, knee issues. However, I want to caution you on this too. So the study that was done by Cox and colleagues in muscles, ligaments, and tendons in the Journal of 2014 showed modest benefits in pain and function compared to controls. And though the effects vary by injury type, PRP preparations can be helpful. You have to understand that a lot of times when people are doing PRP injections in their office, they are not doing it exactly the same way it was done in the study. And not to mention, if you’re using your own PRP to heal a ligament or a tendon or help your arthritis and you’re 60 or 70 years old, That is not good quality protein rich plasma. It is old protein rich plasma. And you’re not going to see necessarily the same benefits that you would see if you were using placental tissue or umbilical tissue. Dr. Deb Muth 25:33You also want to address the nutritional deficiencies or support that’s needed for connective tissue healing. And these are collagen peptides dosed at 15 grams a day. And this has been shown in a study by Shaw and colleagues in the American Journal of Clinical Nutrition in 2017 to augment collagen synthesis when combined with intermittent loading. Vitamin C is also an essential cofactor for collagen production and stabilization of collagen structure at a dose of around 500 to 1000 milligrams a day to support this process. You also need to have good adequate intake of copper and zinc. These are cofactors in collagen. Silica is also important. This comes from horsetail extract. This provides additional support as well. So more importantly, I think remembering that rehabilitation matters as well. Doing these protocols without doing some rehab is not going to get you where you want to go. Dr. Deb Muth 26:33There’s a research study by Alfredson and others for Achilles tendinopathy using the control lengthening of muscle tendon units under load to promote tendon remodeling and healing. These protocols have solid evidence and cost nothing beyond professional guidance from a physical therapist. They are important for patients seeking cutting edge regenerative approaches. Stem cell therapies, growth factors, concentrates derived from patients’ own tissues like PRP. These have a lot of good endogenous materials and they have good safety profiles. BPC-157 represents the perfect example of how promising Preclinical science gets marketed far beyond the evidence and it may eventually prove to be valuable. I think it will. But right now that determination does require some human studies and hopefully with the administration that we have right now and Bobby Kennedy, we will actually start to see some of that occur. Now the next peptide I want to talk about is TB4, thymus and beta-4. Dr. Deb Muth 27:36This is a wound healing peptide. It is a 43 amino acid peptide that’s naturally present in virtually all human cells except red blood cells. It’s actually one of the most abundant peptides in the human body, particularly concentrated in blood platelets, wound fluid, and many tissues. It’s naturally ubiquity makes it mechanistically interesting. The body wouldn’t produce it in such abundance if it didn’t serve a function. So the primary role of TB4 involves building G-actin. It’s a form of monomeric actin. And it’s structural protein that forms the microfilaments within the cells, providing cellular structure and enabling cell movement. TB4 prevents from F-actin filaments. I’m not going to talk too much about this. It’s really critical for wound healing as cells need to migrate into the injury sites. Dr. Deb Muth 28:37so the cell shape changes and the cellular response to the injury. So think of this as though you tore your meniscus and the body created all this TB4 to come to that injury to try to heal that site. That’s exactly what the TB4 is doing inside the body when there’s an injury. It’s been shown in research to help produce new blood vessel formation, promote endothelial cells, It helps modulate inflammatory cytokines, potentially reducing TNF-alpha, IL-1, and possibly protecting in programmed cell death, which we call apoptosis. And some studies suggest that it is cardioprotective in its effects in animal models of myocardial infarction, so heart attack, and neuroprotective in other models for brain injury. Now, these remain to be preliminary, but they are being seen. So the regulatory status on TB4 can create some confusion. Dr. Deb Muth 29:40The natural TB4 molecule itself is not FDA approved as a drug. However, TB4 based drug candidates called RGN259, formerly TB4, has been in the development by regen tree for corneal injuries of the dry eye disease. And as of recent updates, this drug is completed phase three trials for its neurotrophic keratopathy, severe corneal condition. But the FDA approval is still pending. So that means that the most advanced TB4-based pharmaceuticals hasn’t yet crossed the finish line for approval. The commercial peptide market further muddies the picture with TB500, which is often described as the synthetic fragment of TB4. However, this extract’s relationship between TB500 and TB4 varies depending on the source. Dr. Deb Muth 30:41So some claim that TB500 is identical to TB4, but positions 1 through 4 suggest it’s a different fragment. and the quality control across suppliers is not existent. So this confusion is part of why recommending TB500 becomes problematic for practitioners and patients, often because they aren’t certain what molecule they’re actually getting. The evidence base for TB4 in humans is limited, primarily to eye research, and the studies from Sohn’s and colleagues published in journals like Vitamins and Hormones in 2016 have examined topical TB4 for corneal injuries and neurotrophic keratopathy, dry eye, and other surface diseases. Now, these studies showed some promise in promoting this, and there is, however, a topical application to the cornea that is vastly different from a systemic injection. So for systemic use in wound healing, musculoskeletal issues, Dr. Deb Muth 31:42cardiac protection, neuroprotection, human clinical trials. There is scarce to non-existent evidence in humans. Most of the evidence remains in animal models or cell culture studies. And a review by Flip and colleagues in the Journal of Investigational Dermatology in 2006 detailed TB4’s effects on the matrix remodeling during wound repair in animal models, showing effects on collagen disposition, granulation, tissue reformation, and wound contraction. Another review by Ho and colleagues in expert opinion on biological therapy in 2007 discussed TB4’s potential in tissue regeneration and regenerative medicine, but noted the field remained largely blank. preclinical. So this is really important again to understand that there is just not enough human data. So there is a concern with cell division and migration. This theoretically exists Dr. Deb Muth 32:45for the potential effects on cancer cells, which would also rely on migration and division and other intended consequences of disrupting normal cellular architecture. These aren’t proven risks, but they are unexplored questions that we need to be aware of when we’re using peptides. This can cause cancerous tissue to grow. Very similar to what we talked about with BPC-157. These are also sold as research chemicals. There is no FDA oversight. So purity, potency, contaminations all still exist for these peptides. Now from an integrative perspective, the natural presence of TB4 in wound fluid and its biological roles in healing are legitimate science. in presence does not equal therapeutic utility. The body tightly regulates where and when and how much TB4 is present through natural production and bypassing that regulation with external dosing may or may not cause us to have beneficial or introduce risk. Dr. Deb Muth 33:49So we need to know that this is experimental use. Those people who are seeking wound healing and tissue repair the evidence-based approach of the body’s own capacity to heal is huge definitely want to be increasing your protein intake optimizing your zinc copper vitamin c and vitamin a and then managing glucose is really important during this time as well so let’s talk about a fun topic now and that’s growth hormone secretagogues this is the anti-aging hype machine these peptides in this category are things like semoralin ipameralin cjc 1220 1295 and others and among the most aggressively marketed in anti-aging and longevity medicine they all share a common goal stimulating the pituitary gland to release more growth hormone and the appeal is understandable. GH levels decline with age, and this decline is associated with increased fat mass, decreased lean muscle, reduced bone density, and other aspects of aging. Dr. Deb Muth 34:55The other times we’ll see growth hormone levels decline significantly is with chronic illness, and the logic is to restore youthful GH levels and youthful physiology. Now, semirelin from an FDA approved diagnostic to compound anti-aging product. Semirelin is a 29 amino acid peptide representing the first 29 amino acids of the full 44 amino acid human growth releasing hormone, GHRH. We talked about this on another episode of the podcast. And you can go back and listen to that one a little bit if you want. This fragment contains the complete biological activity of the full GHRH molecule and it binds to GHRH receptors in the anterior pituitary and stimulates growth releasing peptides, growth hormone releasing peptides. Semirelin was previously FDA approved as diagnostic testing of growth hormone secretion, essentially, to determine if the pituitary could still respond to GHRH stimulation in patients being evaluated for growth hormone deficiency. Dr. Deb Muth 36:06However, the manufacturer was discontinued and there was no longer an FDA approved semirelin product on the market in the United States. What exists now is semirelin available from compounding pharmacies used off label for anti-aging, body composition, and general growth hormone optimization purposes. This represents a significant gray area. Again, compounding medications serve a very important role, but they need to meet certain recommendations and regulations, as we’ve talked about in the past. You want to make sure that your compounding pharmacy that you’re obtaining semirelin from is qualified to do that, that they are doing best practices, and that you’re getting a good product. The theoretical advantage to semirelin over direct growth hormone administration is that it preserves more of the physiological growth hormone secretion patterns. Natural GH is released in pulses, primarily during sleep, not as a continuous elevation. Dr. Deb Muth 37:07So semirelin stimulates the pulses rather than providing a constant super physiological growth hormone level. And that pulsatile pattern is thought to reduce some of the side effects and metabolic concerns that we have with continuous growth hormone exposure. However, the evidence supporting semirelin for anti-aging and body composition in healthy adults is minimal. Most of the data comes from studies conducted in the 1990s when the FDA approved product existed. Not that that means it’s bad. We have drugs that have been in the market for over a hundred years that are still there, that still have the research and are still being used successfully and safely today. So we don’t want to let that really make us think that this product isn’t safe. So a 2006 review from Walker in Clinical Interventions of Aging suggested that semirelin might be a better approach than direct GH for adult onset growth hormone insufficiency, but they do acknowledge that the evidence was limited. Dr. Deb Muth 38:12And although we don’t have any large scale trials that we can examine for semirelin’s efficacy, it is now commonly prescribed. And the optimal dosing for anti-aging purposes is still unknown. It is considered experimental and it does vary from person to person, but it is still unstudied. The effects on cancer risk, cardiovascular disease, metabolic dysfunction over long time periods are also still unknown. I would argue that the side effects or the risk factors of not having growth hormone are equally as bad as the unknowns that we have here. We’re not looking to try to get super physiological doses. We’re trying to restore youthful GH levels. Typically, we’re not trying to restore back to a 20-year-old. We’re trying to restore back maybe 10 years. That is a better way of doing this. And I think that’s important for people to understand. Now, ipamirelin is the ghrelin mimicker. Dr. Deb Muth 39:12Ipamirelin is a pent-up peptide, five amino acid, that acts as a growth hormone secretagogue receptor, a GHS-R agonist. It mimics the action of ghrelin, the hunger hormone, that also stimulates growth hormone release. The proposed advantage over earlier secretagogues is that ipamirelin stimulates growth hormone release without significantly affecting cortisol, prolactin, or other glucose things, which can be increased by growth hormone secretagogues. The regulatory status is clear. Ipamirelin is not FDA approved for any indication. It’s sold as a research chemical. Human evidence is thin. It’s limited to single dose studies examining how quickly it’s absorbed and metabolized with minimal data on dosing and clinical outcomes. Now there are marketing claims for ipamirelin and they are extensive. Dr. Deb Muth 40:13It increases lean muscle mass, it decreases body fat, it improves sleep quality, faster recovery from workouts, enhanced injury healing, better skin quality. The evidence supporting these claims in humans is not available we don’t have it these are claims that are made by the effects that we know from growth hormone so it’s not necessarily a bad thing we know what growth hormone does we know growth hormone does all of these things if ipamorelin is a precursor to that it will obviously help improve those things making that correlation of what growth hormone does So there are safety concerns that mirror the same as any other growth hormone elevating therapy. It can cause fluid retention, joint pain, carpal tunnel syndrome, insulin resistance, glucose intolerance, and theoretically, can it increase calcium? cancer risks? It can because IGF-1 promotes cell proliferation and can inhibit apoptosis in cancer cells. Now remember, your body makes IGF-1. Dr. Deb Muth 41:15If it’s not making enough of it, that’s a problem. If it’s making too much of it, That’s a problem. So just understand that if you are adding these things, and especially in elevated doses, you are taking a potential risk. So there is also now CJC 1295 is a modified GHRH analog of 30 amino acid peptide based on GHRH structure, but with modifications. So it includes the addition of drug affinity complex, DACC, DAC, which involves conjugation with a small albumin binding molecule, dramatically extends the peptide’s half-life from minutes to as much as potentially a week or more. And this creates sustained growth hormone elevation rather than that pulsatile release. There are actually two versions of this. There’s CJC 1295 with DAC, longer acting version, and CJC 1295 without DAC, which is essentially a shorter duration of semirelin. Dr. Deb Muth 42:19And so when we’re comparing products, it is… only the difference between long acting and short acting. The human evidence for CJC 1295 is limited to a single published phase one study by Techman and colleagues in the Journal of Clinical Nutrition and Metabolism in 2006. And the study involves 18 healthy young adults showed that CJC 1295 with DAC produced a sustained elevation of GH and IGF-1 lasting several days after the injection. That’s essentially the entire published human evidence of this peptide. There are no phase two studies examining optimal dose. So that is all considered experimental. And there is no phase three studies examining clinical efficacy. So the sustained GH levels created by CJC 1295 with DAC raises specific concerns because the natural GH secretion It goes up and down, up and down, up and down. Dr. Deb Muth 43:19And that constant elevation may have a different metabolic and cellular effect. And we just really don’t know what that’s going to be yet. So we can understand that elevated IGF-1 levels can theoretically increase cancer concerns and metabolic risks. So rather than always injecting peptides, which are very expensive… You can do other things. And there was a study by Hartman and colleagues in the Journal of Clinical Endocrinology and Metabolism in 1992 that demonstrated the 48-hour fast increased integrated growth hormone secretion five-fold through increased GH levels. Now, the problem with this is fasting for 48 hours is a challenge. And how long is it going to increase the growth hormone secretion without causing issues? Or in general, how long is it going to go up? Dr. Deb Muth 44:19So we have to be cautious about that as well. Sleep optimization is non-negotiable. The majority of growth hormone secretion occurs during sleep, slow wave sleep, typically the first sleep cycle, and poor sleep quality or insufficient sleep typically. can dramatically affect your growth hormone levels. And then high intensity interval training, HIIT resistance training can stimulate growth hormone as well. This was seen in a study by Godfrey and colleagues in sports medicine in 2003 and was examined in exercise-induced growth hormone responses to athletes. So we definitely see these kinds of things. So let’s talk about some longevity peptides now. These expand the telomere. So there’s epitalin and epithalamin and when these are used in anti-aging they can produce some amazing results. Dr. Deb Muth 45:22So epitalin is a synthetic terapeptide, just four amino acids. It was originally synthesized as a simplified version of epithalamine. a pineal gland extract containing multiple peptides. The synthetic four amino acid version was created to isolate what researchers believed might be the active anti-aging component. The mechanism produced for epitalin centers on telomere and telomerase, Telomeres are protective caps at the end of the chromosomes consisting of repetitive DNA sequencing. And every time a cell divides, telomeres shorten slightly because DNA polymers cannot fully replicate the ends of the linear chromosomes. So this progressive shortening acts as a molecular clock. After 50 or 70 divisions, the telomeres become critically short, triggering a cellular senescence. Dr. Deb Muth 46:22This telomere shortening is one mechanism of cellular aging and telomeres in the enzyme that can rebuild telomeres by adding these caps back onto the end of the chromosome. It’s active in stem cells, germ cells, and unfortunately in about 85 to 90% of the cancer cells. In most adult somatic cells, telomerase is inactive or present at very low levels, allowing the telomeres to shorten with division. The research on epitalin suggests it might activate this telomeres act telomeres process primarily from a research group led by Vladimir in Russia. Vladimir Kavasan in Russia. He is a huge peptide researcher or was he passed away with publications dating back to the early 2000s and a study published in bio gerontology in 2000 by Kavasan Dr. Deb Muth 47:25and colleagues examined the effect of epitalin on the lifespan of fruit flies, and they treated fruit flies that showed a modest increase in mean and maximum lifespan compared to its controls by approximately 10 to 15% lifespan extension in some experimental groups. And there were other studies in 2003 that examined epitalamine in a female Swiss-derived mouse. This was done by Ann Simove and colleagues. And the researchers reported that epitalin treatment was associated with increased lifespan as well. And the most cited mechanistic work comes from cell culture studies. And that is also Cavason’s group that published this research in 2003, showing increased telomeres activity in cultured somatic cells again. More recently, between 20 and 25, the series of publications have continued to explore epithelial effects on telomere dynamics in cell cultures. Dr. Deb Muth 48:32So there is a lot of research that’s been done. The mass majority has been done on epithelin. And most of it has been done by a single research group in Russia. There is some restrictions on some of the cell culture data that we’re seeing. And it does show that epithelin sometimes can be described as a regulating hormone. Carcadian rhythm for melatonin production, which is derived by the penile extracts. And however the evidence for this affects minimally and mechanistically unclear, the pineal gland primarily functions as melatonin secretion in that light-dark cycles. So Epithalin or epitalin is not FDA approved. It is not approved for any major regulatory jurisdiction. It is sold as a research chemical only. Dr. Deb Muth 49:33So you need to follow the same safety profiles that we’ve talked about in other episodes and in today’s episodes. And when we’re talking about epithalin, and we’re excited about it being an anti-aging science, we should balance this with the honesty and the evidence of the quality of that evidence. We don’t know its safety effect. We don’t know if it’s going to increase the risk of cancer. We can’t verify that. And we need to be using it in an experimental use of unknown risks only. Of course, diet, physical activity, stress management, sleep quality, all of those things are important for us to be looking at when we’re looking at these peptides. Now, I want to get into some of the brain peptides. This is the nootrophic frontier. C-Max and C-Lank, there is Russian pharmacology that’s done. C-Max and C-Lank represent an interesting case study in how different regulatory environments and research traditions Dr. Deb Muth 50:36create challenges in evaluating this evidence. Both peptides were developed in Russia, are approved for their specific indications and have substantial Russian language and literature supporting their use. However, the FDA approval in the United States is still not there. C-Max is a seven amino acid. It’s a synthetic analog. It is a fragment, particularly ACTH 4 through 10. It’s sometimes called the melanocortin effects because it involves the melanocortin receptors of the central nervous system. CMAX was developed by the Institute of Molecular Genetics of Russia Academy of Sciences and is approved in Russia for several indications, including acute stroke, transient ischemic attacks, cognitive disorders. It has Russian approval and is based on clinical trials primarily in Russia. Dr. Deb Muth 51:39It does help to increase brain-derived neurotrophic factor, BDNF, a protein critical for neuroplasticity, the brain’s ability to form new connections and adapt to the challenges. BDNF supports neuronal survival and promotes growth of these new neurons. C-Max also influences neurotransmitter systems, particularly dopamine and serotonin, and there is some research that suggests it affects on metabolism as well, and endogenous opioid peptides that involve pain reception and mood regulation. So it has some good potentials there. There is also C-Link, which is a hepatopeptide structurally similar to Tufts’ and an immune modulatory peptide. It was also developed in Russia and was approved for anxiety disorders as a neurotropic. Its effects involve anxiolytic effects, possibly through the GABAnergic system or the GABA system of the brain, and immune modulation. Dr. Deb Muth 52:44The Russian research is examined by C-Link for anxiety disorders. and finding reductions in anxiety without sedation. There is a dependency potential or cognitive impairment does not exist like it does with benzodiazepines with C-Link. So that is really good. And they do report attention and memory improvement using C-Link. There is a study that was done in neuroscience and behavioral psychology in 2018 that examined C-Linx effects and proposed that it exerts cytoprotective effects through BDNF pathways similar to C-Max. So both of these are Russian research-based They’re not wrong or fraudulent. It’s just that they are from Russia and we all have our concerns with Russia. However, that does not necessarily mean their research doesn’t hold quality. Dr. Deb Muth 53:49Neither peptide is approved by the FDA, and so you are using this off-label. The same rules apply for all of the other peptides that we’ve talked about that are produced off label. You want to do the same things that you would do with anything else. Good protein, omegas, B vitamins, acetylcarnitine, exercise, sleep, all of that still applies when we’re using these peptides. So I want to talk briefly about clinical decision and framework when we’re looking at this. First and foremost, we always want to go to FDA-approved peptides. Secondly, we would look at international approval with peptides that are established in other countries but lack FDA approval. And then preclinical evidence only or experimental peptides. These can be used, but they are not ethically recommended in the traditional medicine world. Dr. Deb Muth 54:50 If patients use them, we need to have appropriate counseling about the evidence surrounding them, the safety, and where to find them. how to find them and how to ask for these certificates of analysis. So I think it’s really good that we were exploring all these peptides and understanding what they are. There’s a lot of controversy out there. There’s a lot of concern out there. And what we can say with confidence is that peptides are powerful biological signaling molecules. Some peptide based medications, semi-glutide, triseptide, PT 141, Lupron that are all FDA approved. can dramatically improve outcomes in patients that are obviously selected for the correct ones. There are many other peptides that we address that are integrative and longevity space in the regenerative medicine. These peptides are all experimental. That does not automatically make them wrong. Dr. Deb Muth 55:50It just means that we need to be honest about what we’re doing with them and we need to be cautious with the patients so that they can make a decision to be part of an experimental study. in looking at how to use these peptides. So peptides are tools like any other tools. They work best in the hands of skilled people, and they are applied to appropriate situations, integrating into comprehensive approaches that address root causes. The most powerful peptide administered to a patient with untreated inflammation, hormonal chaos, nutritional deficiencies, and disorders of sleep will disappoint. The simplest evidence-based interventions apply. to a patient whose foundational physiology has been optimized. And this is the art of the science of peptide, right? If done right, respecting both the power of these molecules and the complexity of human beings that we are privileged to serve can make a difference in their lives. So thank you for listening to this episode. Dr. Deb Muth 56:52I hope this was helpful. If you can know of somebody that might benefit from this, please like, share, and subscribe. It means a lot to us. And I hope you join us for our next episode of Let’s Talk Wellness Now. Welcome to Let’s Talk Wellness Now, where we bring expert insights directly to you. Please note that the views and information shared by our guests are their own and do not necessarily reflect those of Let’s Talk Wellness Now, its management, or our partners. Each affiliate, sponsor, and partner is an independent entity with its own perspectives. Today’s content is provided for informational and educational purposes only and should not be considered specific advice, whether financial, medical, or legal. While we strive to present accurate and useful information, we cannot guarantee its completeness or relevance to your unique circumstances. We encourage you to consult with a qualified professional to address your individual needs. Dr. Deb Muth 57:54Your use of information from this broadcast is entirely at your own risk. By continuing to listen, you agree to indemnify and hold Let’s Talk Wellness Now and its associates harmless from any claims or damages arising from the use of this content. We may update this disclaimer at any time and changes will take effect immediately upon posting or broadcast. Thank you for tuning in. We hope you find this episode both insightful and thought-provoking. Listener discretion is advised.The post Episode 258 – Investigational Peptides: What's Promising, What's Hype & What You Must Know first appeared on Let's Talk Wellness Now.

This week we speak with Professor James Cnota of Cincinnati Children's Hospital about a recent report he co-authored from the SVR trial regarding the impact of tricuspid regurgitation (TR) on outcomes in hypoplastic left heart syndrome (HLHS). How common is TR seen in the HLHS patient and how does this change over time after surgical palliations? Is there an optimal time to intervene on the tricuspid valve in this patient group? What does the future hold for tricuspid surgical interventions? Dr. Cnota has the answers this week. doi: 10.1007/s00246-025-04122-x

Mankrachttekort Rusland en Oekraïne | Trumps State of the Union | Gesprekken en oorlogsvoorbereiding Iran Rusland en Oekraïne raken verder verstrikt in een uitputtingsoorlog waarin drones het dertienhonderd kilometer lange front domineren en grote doorbraken uitblijven. Arend Jan Boekestijn en Rob de Wijk duiden hoe Oekraïne bij Huljaipole enkele kilometers opschuift, terwijl beide legers kampen met personeelstekorten, verouderde rekruten en een dodelijke “kill zone” die grote offensieven praktisch onmogelijk maakt. Rusland probeert diplomatieke en militaire tegenslag te maskeren met kernwapenbluf en desinformatie over vermeende Britse en Franse nucleaire leveringen aan Oekraïne. De inlichtingendienst SVR, Kremlin-roeptoeter Dmitri Medvedev en staatsmedia pompen het verhaal rond, terwijl in Europa zorgen groeien over Russische sleeper-structuren en de kwetsbaarheid van energievoorziening via de Druzjba-pijplijn. Trump polariseert intussen de Amerikaanse politiek met een harde migratieretoriek, wispelturige handelstarieven en scherpe aanvallen op de Democraten. In het Midden-Oosten bereiden Iran en de Revolutionaire Garde zich voor op mogelijke Amerikaanse aanvallen, terwijl munitievoorraden, luchtverdediging en regionale escalatie het strategische speelveld extra kwetsbaar maken voor misrekeningen. Over de Podcast Arend Jan Boekestijn en Rob de Wijk gaan onder leiding van Hugo Reitsma op zoek naar de nieuwe wereldorde. Wat betekenen oorlog, machtspolitiek en economische verschuivingen voor Europa en Nederland? In elke aflevering duiken zij in de geopolitieke actualiteit. In 2022 werd Boekestijn en De Wijk uitgeroepen tot winnaar in de categorie Nieuws & Politiek tijdens de Dutch Podcast Awards Reageren? Op X: @ajboekestijn en @robdewijk Bluesky: @hugoreitsma.bsky.social Mail: boekestijndewijk@bnr.nl Over de makers: Arend Jan Boekestijn is een Nederlands historicus en voormalig politicus. Hij studeerde geschiedenis en politieke wetenschappen aan de Vrije Universiteit in Amsterdam. Boekestijn is voormalig Tweede Kamerlid (tot 2009). Sinds 1989 is hij verbonden aan de vakgroep geschiedenis van de Universiteit Utrecht en sinds 2016 lid van commissie Vrede en Veiligheid van AIV. Rob de Wijk studeerde eigentijdse geschiedenis en internationale betrekkingen, promoveerde op kernwapenstrategieën, werd hoogleraar in Leiden en richtte in 2007 het Den Haag Centrum voor Strategische Studies op. Hugo Reitsma studeerde rechten en politicologie. Hij werkte eerder als politiek verslaggever en vanuit verschillende conflictgebieden. Hij is auteur van het boek ‘Boekestijn en De Wijk voorspellen de toekomst’ (november 2023).See omnystudio.com/listener for privacy information.

V Ukvah v Kanalski dolini je minuli petek Slovensko kulturno središče Planika pripravilo proslavo ob slovenskem kulturnem prazniku. V večnamenski dvorani nekdanje mlekarne so nastopili učenci slovenskega jezika, Christina Chersi na prečni flavti, violinist Maurizio Magrelli, učenci Glasbene matice FJK ter koroška vokalna skupina Svrž pod vodstvom Aleksa Schusterja. Slovenski inštitut na Dunaju pa bo prireditev ob slovenskem kulturnem prazniku pripravil jutri v svojih prostorih na Hanuschgasse. Spored slavnostne prireditve KULTURfest3 oblikujejo člani najstarejšega tamburaškega ansambla na Dunaju ADRiA, pesnika in pisatelja Lev Detela ter Ondřej Cikán, ki objavljata svoja dela v češkem, slovenskem in nemškem jeziku. Prireditev je namenjena tudi 150. obletnici rojstva Ivana Cankarja ter šolski ustanovi dunajskih Čehov, Komensky, s katero inštitut sodeluje glede pouka v slovenskem jeziku. Tako se veselijo tudi nastopa maturank šole Komensky

En este episodio de A GUSTO EN MI PIEL by SVR hablamos de un tema que genera cada vez más preguntas: los disruptores endocrinos. ¿Qué son exactamente? ¿Cómo entran en el cuerpo? ¿Por qué pueden afectar al sistema hormonal y al metabolismo? Junto a Anna Sala, farmacéutica y médico pediatra, explicamos el concepto de exposoma, por qué el impacto puede pasar desapercibido durante años y cuáles son las etapas más vulnerables: embarazo, primeros 1000 días de vida y preadolescencia/pubertad. También repasamos medidas prácticas para reducir la exposición en casa: ventilación, limpieza, cocina, textiles, juguetes y cosmética infantil. En la sección final, con Beatriz Garde, desmontamos creencias habituales y aclaramos por qué “si es para bebés” o “si está aprobado” no siempre significa que sea la opción más segura sin revisar ingredientes y certificaciones.

Tokenized assets could be crypto's next megatrend with trillions waiting to flow onchain.In today's episode, we sit with Zach Rynes from Chainlink to explore their Atlas acquisition, how SVR recaptures liquidation value, and why institutional-grade infrastructure positions DeFi for the tokenization era ahead.We discuss:- The Atlas Acquisition: Scaling SVR Across Chains- How Chainlink Recaptures $10M+ in Liquidation MEV- Why Institutions Are Finally Ready to Tokenize- DeFi's Role in the Neo-Finance Era- The Infrastructure Play for Trillions OnchainTimestamps:00:00 Intro02:40 Zach's Smart Con Reflections05:18 SVR Breakdown: Recapturing MEV06:51 Halliday, infiniFi, Kalshi Ads10:01 How Atlas Fits Into Chainlink's Vision13:08 The Tokenization Megatrend15:30 Relay, Trezor Ads15:33 Quality Assets: The Missing Piece18:49 Asset Layer vs Protocol Layer20:06 Zach's 2026 Outlook22:31 Closing ThoughtsWebsite: https://therollup.co/Spotify: https://open.spotify.com/show/1P6ZeYd...Podcast: https://therollup.co/category/podcastFollow us on X: https://www.x.com/therollupcoFollow Rob on X: https://www.x.com/robbie_rollupFollow Andy on X: https://www.x.com/ayyyeandyJoin our TG group: https://t.me/+TsM1CRpWFgk1NGZhThe Rollup Disclosures: https://goodidea.ventures

What happens when a secret police force writes its own novels? In this episode of Spymasters, Antonia Senior is joined by academic and KGB expert Filip Kovacevic to explore the hidden world of Soviet spy fiction—and the extraordinary role it played inside the KGB itself. Drawing on his book KGB Literati, Kovacevic reveals how intelligence officers, counter-spies, and veterans of state security became novelists, producing stories designed to shape public opinion, recruit future officers, and redefine the image of the KGB within Soviet society. From the early post-war novels of Roman Kim to the officially sanctioned Chekist Stories series produced by the KGB Press Bureau, the conversation uncovers how fiction became a tool of counterintelligence, psychological influence, and regime legitimacy. We also examine why Western intelligence analysts paid close attention to these books, how they influenced a young Vladimir Putin, and why the tradition continues today under the FSB and SVR. A deep dive into propaganda, imagination, and power—and a reminder that in espionage, stories can be as important as secrets. Find the book: https://amzn.eu/d/fRVZgoI Find Filip on X: @chekistmonitor on the web: thechekistmonitor.blogspot.com on substack: https://kgbstack.substack.com/ Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week we review a recent report of the use of phenoxybenzamine for the reduction of SVR in children undergoing congenital heart surgery in India. How does this agent work and what might be the advantage versus other agents like nitroprusside or milrinone which are more commonly used? How does the cost of this agent (or phentolamine) compare with newer agents? We speak with Dr. Rohit Loomba of Lurie Children's Hospital. For those interested, in addition to working as a critical care cardiologist, Dr. Loomba is also a noted cardiac morphologist and his wonderful videos can be seen at the following web address:https://www.youtube.com/@Talking_HeartsToday's paper:DOI: 10.4103/jpbs.jpbs_868_25

Join us for this informative and enlightening podcast as we delve into the complexities and nuances of the Simple View of Reading (SVR). Our distinguished guest, Dr. Wesley Hoover, will explore how SVR remains a foundational cognitive theory that effectively captures the critical relationship between language comprehension and word recognition in determining reading comprehension.Dr. Hoover will discuss the key elements of the SVR, clarifying its purpose as a cognitive theory rather than a mere description or heuristic. Our conversation will reveal common misconceptions about reading, emphasizing that while it may seem simple, the interplay of its two critical components—word recognition and language comprehension—reveals a much richer complexity. Dr. Hoover will also introduce the Cognitive Foundations Framework (CFF), an extension of the SVR that expands our understanding of the skills and abilities required for achieving effective reading.Whether you're a teacher, an administrator, or simply passionate about literacy, this podcast offers a deeper understanding of what it truly means to learn to read, the cognitive capacities involved, and how we can better support learners on their journey.Listeners will learn:An understanding of the SVR and its importance in reading comprehension researchThe complexities and limitations of the SVR, including some unanswered questions about reading skills and developmentThe roles of word recognition and language comprehension as the two essential proximal capacities necessary for reading successDetails about the Cognitive Foundations Framework (CFF) and how it serves to expand the SVR's insights about reading skillsEffective strategies and approaches for reading instruction and remediation based on the insights derived from the SVR and CFFPractical applications for educators and parents to better support learners and foster reading proficiencyTune in for this thought-provoking conversation that will challenge assumptions and celebrate the intricacies of reading! Listeners will leave with a richer understanding of the cognitive foundations of reading and how to apply this knowledge in various educational contexts.

Cerramos la tercera temporada de “A GUSTO EN MI PIEL” con un episodio especial que pone en el centro vuestras dudas reales sobre el acné. Desde granos adolescentes hasta brotes en la menopausia, la farmacéutica Beatriz Garde responde caso a caso con rutinas dermocosméticas eficaces, seguras y adaptadas. Hablamos de acné hormonal, acné corporal, acné fúngico, marcas post tratamiento y mucho más, junto a Néstor Amorín del equipo SVR. ¡Un episodio imprescindible para aprender a cuidar tu piel en cualquier etapa de la vida! Gracias por acompañarnos una temporada más. Ha sido un placer crecer, aprender y cuidarnos juntos. Nos vemos muy pronto… y hasta entonces, gracias por hacernos sentir tan a gusto en nuestra piel.

BANG! @southernvangard radio Ep447! This is the shortest episode of SVR in history - long story short, DJ JON DOE's 13 year old audio interface took a small dump before the show started, and took the ultimate dump right as the second set started. Don't fret - we got the studio in shape and delivered 448 in typical fashion the following week. Nonetheless - trash talk and new joints were abound in the first set and YOU still WAAAAALCOME #SMITHSONIANGRADE #YOUWAAAAALCOME // southernvangard.com // @southernvangard on all platforms #hiphop #rap #undergroundhiphop #boombap ---------- Recorded live August 24, 2025 @ Dirty Blanket Studios, Marietta, GA southernvangard.com @southernvangard on all platforms #SmithsonianGrade #WeAreTheGard twitter/IG: @southernvangard @jondoeatl @cappuccinomeeks ---------- Pre-Game Beats - Kista “Southern Vangard Theme” - Bobby Homack & The Southern Vangard All-Stars Talk Break Inst. - “Hamburgers With Wimpy” - Observe “Back To The Ninetees” - Blahzay ft. Smooth The Hustler & REDDDAZ “Hard On The Boulevard” - Vursatyl ft. Lunden Benard and Krisy Hendrixx “Ancestors” - Ras Kass x Ras Ceylon x Ka'Ra “We On” - Halfcut & Cole The God ft. Reks “Broadcasting Live” - Silent Funk (Rhinoceros Funk, Silent Someone & DJ JS-1) “Night Life” - Kidd Called Quest ft. Mooch Talk Break Inst. - “I Feel Down” - Observe

In this episode of the CISO Tradecraft podcast, host G Mark Hardy speaks with Tim Brown, the CISO of SolarWinds, at the Black Hat conference in Las Vegas. They delve into the details of the infamous SolarWinds breach, discussing the timeline of events, the involvement of the Russian SVR, and the immediate and long-term responses by SolarWinds. Tim shares insights on the complexities of supply chain security, the importance of clear communication within an organization, and the evolving regulatory landscape for CISOs. Additionally, they discuss the personal and professional ramifications of dealing with such a high-profile incident, offering valuable lessons for current and future cybersecurity leaders. Chapters 00:00 Introduction and Welcome 00:59 The SolarWinds Incident Unfolds 03:13 Understanding the Attack and Response 04:04 The Role of SVR and Supply Chain Security 10:43 Technical Details of the Attack 14:56 Compliance and Reporting Challenges 19:24 Rebuilding Trust and Personal Impact 22:06 CISO Concerns and Company Support 22:14 Legal Challenges and Company Expenses 23:40 SEC Charges and Legal Proceedings 29:35 Supply Chain Security and Vendor Assurance 35:47 CISO Accountability and Industry Standards 39:41 Final Thoughts and Advice for CISOs

In this episode of the CISO Tradecraft podcast, host G Mark Hardy speaks with Tim Brown, the CISO of SolarWinds, at the Black Hat conference in Las Vegas. They delve into the details of the infamous SolarWinds breach, discussing the timeline of events, the involvement of the Russian SVR, and the immediate and long-term responses by SolarWinds. Tim shares insights on the complexities of supply chain security, the importance of clear communication within an organization, and the evolving regulatory landscape for CISOs. Additionally, they discuss the personal and professional ramifications of dealing with such a high-profile incident, offering valuable lessons for current and future cybersecurity leaders. Chapters  00:00 Introduction and Welcome 00:59 The SolarWinds Incident Unfolds 03:13 Understanding the Attack and Response 04:04 The Role of SVR and Supply Chain Security 10:43 Technical Details of the Attack 14:56 Compliance and Reporting Challenges 19:24 Rebuilding Trust and Personal Impact 22:06 CISO Concerns and Company Support 22:14 Legal Challenges and Company Expenses 23:40 SEC Charges and Legal Proceedings 29:35 Supply Chain Security and Vendor Assurance 35:47 CISO Accountability and Industry Standards 39:41 Final Thoughts and Advice for CISOs

Pos Report propose du 29 juillet au 19 août sa série estivale baptisée Un été à foils, l'occasion d'écouter ou de réécouter des épisodes de la saison écoulée avec des invités naviguant sur des supports à foils. Retour ce mardi sur l'épisode #209, enregistré le 22 avril dernier, avec comme invités les skippers des Ultim SVR Lazartigue et Actual Ultim : Tom Laperche et Anthony Marchand--Ce 209e épisode de Pos. Report est consacré à deux marins de la classe Ultim, celle des multicoques volants : Tom Laperche et Anthony Marchand.Tandis que le skipper de SVR Lazartigue embarque Franck Cammas cette saison, le skipper d'Actual apprend à connaître l'ancien Gitana 17, acquis cet hiver par son partenaire. Alors que leur bateau est encore en chantier, les deux marins ont profité du week-end de Pâques pour régater dans le cadre du Spi Ouest-France à La Trinité-sur-Mer. Outre la convivialité, pas question de se laisser distancer par les « vieilles » connaissances : l'équipage de Tom Laperche, « made in SVR » devance le Team Banque Populaire de Loïs Berrehar en Open 7,50. Anthony Marchand se contente de la quatrième place en Mach 6,50.S'il leur faut attendre l'été pour la mise à l'eau de leur Ultim, le programme est intense : Anthony Marchand et son équipe démontent - puis remontent - les pièces du futur Actual Ultim 4. Le marin de Plérin raconte aussi l'acquisition du simulateur, jumeau numérique du bateau pour accélérer la prise en main. Le mât est attendu sous peu alors que les travaux « cosmétiques » sont engagés.Côté SVR-Lazartigue, Tom Laperche revient sur la frustration des 5 tentatives hivernales de Trophée Jules Verne et les enseignements tirés en matière de fiabilisation. De nouveaux appendices sont attendus. Il se confie aussi sur sa découverte du mode record… un challenge auquel Anthony Marchand se frotterait bien avec sa nouvelle machine.Après trois années passées aux côtés de François Gabart, ou Pascal Bidégorry, Tom Laperche raconte son tandem avec l'expérimenté Franck Cammas : le vainqueur de la Solitaire du Figaro 2022 espère bien tirer profit de son expérience récente sur la Coupe de l'America en termes de développement et d'innovation.Les deux hommes se projettent enfin sur la Transat Café l'Or (départ le 26 octobre du Havre). Si Anthony Marchand reste mystérieux sur l'identité de son co-skipper, il concède qu'un profil navigateur / routeur a retenu toute son attention, au regard des règles désormais en vigueur (pas de routage depuis la terre). Après ses deuxièmes places en 2021 et 2023, Tom Laperche rêve quant à lui de victoire en 2025 avec des arrivées d'Ultim « dans le même quart d'heure en Martinique ! ».Rediffusé le 29 juillet 2025Diffusé le 22 avril 2025Générique : Fast and wild/EdRecordsPost-production : Grégoire LevillainHébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

Unleashed: The Political News Hour with Bruce Robertson – Explore unsettling political assassinations in Minnesota, global tensions hinting at World War III, and rising conflicts in Eastern Europe and the Middle East. Delve into record-breaking border security under Trump, the failed “No Kings” protests, and alleged SVR warnings of false flag operations poised to draw the US into war...

Vláda Petra Fialy čelila v Poslanecké sněmovně už čtvrtému pokusu opozice o vyslovení nedůvěry. Důvodem byla bitcoinová aféra. Koalice ale i tentokrát přežila. Má opozice ve spojitosti s bitcoinovou kauzou další plány?Hostem Ptám se já byl místopředseda hnutí ANO Karel Havlíček. Vláda Petra Fialy (ODS) ustála čtvrtý opoziční pokus o vyslovení nedůvěry. Koaliční strany ODS, STAN, KDU-ČSL a TOP 09 se navzájem podržely. Svržení kabinetu podpořili jen přítomní poslanci opozičních hnutí ANO, SPD a Pirátů. Pro vyslovení nedůvěry vládě hlasovalo 94 poslanců, pro svržení kabinetu by bylo nutných nejméně 101 hlasů. Hlasování o nedůvěře vyvolali představitelé hnutí ANO kvůli miliardovému daru v bitcoinech ministerstvu spravedlnosti. Podle místopředsedy hnutí Karla Havlíčka šlo o nezbytný a politicky správný krok: „Na druhou stranu jsem pragmatický člověk a byl jsem prakticky přesvědčen, že se to nepodaří. Nicméně to, že se grilovali ministři, zejména Zbyněk Stanjura a Petr Fiala, bylo nesmírně dobře. Lidé si mohou udělat sami obrázek, jak kdo mluvil, jak kdo lhal, jak kdo se vytáčel.“Podle Havlíčka mělo ANO od ministerských úředníků informace, že šéf financí Stanjura o dopise z resortu spravedlnosti týkajícího se bitcoinů věděl. Ministr tvrdí, že o problematickém daru netušil do poslední chvíle. „Ukázalo se, že pan Stanjura je lhář. A to je realita,“ prohlásil Havlíček. Ten v rozhovoru také nastínil, jaké kroky jeho hnutí plánuje hned první den vlády, pokud vyhraje říjnové volby do Poslanecké sněmovny. „Toho bude takové množství, že mám pocit, že ten den by měl mít víc hodin,“ řekl místopředseda ANO v nadsázce. „Ukážeme, že jsme připraveni.“Chce ANO kvůli bitcoinové kauze dál tlačit na konec někoho z ministrů? Kde by hnutí vzalo peníze na sliby, které před pár dny nastínil Andrej Babiš? A jaké odborníky od SPD by ANO vzalo do své vlády?--Podcast Ptám se já. Rozhovory s lidmi, kteří mají vliv, odpovědnost, informace.Sledujte na Seznam Zprávách, poslouchejte na Podcasty.cz a ve všech podcastových aplikacích.Archiv všech dílů najdete tady. Své postřehy, připomínky nebo tipy nám pište prostřednictvím sociálních sítí pod hashtagem #ptamseja nebo na e-mail: audio@sz.cz.

En este episodio de A GUSTO EN MI PIEL by SVR nos sumergimos en un tema crucial: la sostenibilidad en la industria dermocosmética y su impacto directo en la biodiversidad marina. ¿Sabías que muchos envases, exfoliantes y filtros solares afectan gravemente a los océanos? ¿O que las tortugas marinas están ingiriendo plásticos que encontramos en el mar? Charlamos con Lucía Garrido, responsable de clínica y rescate en la Fundación CRAM, una organización dedicada a la conservación de animales marinos, para entender cómo la industria cosmética puede contribuir (¡o perjudicar!) al equilibrio del ecosistema marino. Hablamos de ingredientes, envases, microplásticos, filtros solares y cómo tus decisiones como consumidor pueden marcar la diferencia. Además, Beatriz Garde, Farmacéutica y Training Manager de SVR, nos acompaña en este capítulo donde analizamos si es verdad que los filtros solares contaminan... o si hay mucha leyenda urbana detrás.

In this episode of the Power Vertical Podcast, Justin Sherman joins host Brian Whitmore to unpack the complex ecosystem behind Russia's offensive cyber operations. From government agencies like the GRU and SVR to loosely affiliated cybercriminals and patriotic hackers, Sherman explores how these entities operate—often independently, yet in alignment with state interests.

En este episodio de A GUSTO EN MI PIEL by SVR hablamos de una de las moléculas más mencionadas (y no siempre bien entendidas) en el mundo del cuidado facial: el colágeno. ¿Qué es? ¿A qué edad empezamos a perderlo? ¿Cómo podemos estimular su producción desde dentro y desde fuera? ¿Y funcionan realmente las cremas y suplementos con colágeno? Junto a Marina García, farmacéutica experta en dermocosmética, resolvemos todas estas dudas y repasamos los mejores activos para mantener una piel firme, hidratada y luminosa. Conduce el episodio Néstor Amorín, del equipo SVR, y como siempre, cerramos con nuestra sección “Desmontando Mitos”, con Beatriz Garde, Farmacéutica y Training Manager de SVR, donde desvelamos si algunas de las creencias más virales… son verdad o puro cuento.

RISC Zero publishes a white paper for Boundless Protocol. Chaos Labs releases an SVR monitoring dashboard. And Tally raises an $8 million Series A. Read more: https://ethdaily.io/688

Ce 209e épisode de Pos. Report est consacré à deux marins de la classe Ultim, celle des multicoques volants : Tom Laperche et Anthony Marchand.Tandis que le skipper de SVR Lazartigue embarque Franck Cammas cette saison, le skipper d'Actual apprend à connaître l'ancien Gitana 17, acquis cet hiver par son partenaire. Alors que leur bateau est encore en chantier, les deux marins ont profité du week-end de Pâques pour régater dans le cadre du Spi Ouest-France à La Trinité-sur-Mer. Outre la convivialité, pas question de se laisser distancer par les « vieilles » connaissances : l'équipage de Tom Laperche, « made in SVR » devance le Team Banque Populaire de Loïs Berrehar en Open 7,50. Anthony Marchand se contente de la quatrième place en Mach 6,50.S'il leur faut attendre l'été pour la mise à l'eau de leur Ultim, le programme est intense : Anthony Marchand et son équipe démontent - puis remontent - les pièces du futur Actual Ultim 4. Le marin de Plérin raconte aussi l'acquisition du simulateur, jumeau numérique du bateau pour accélérer la prise en main. Le mât est attendu sous peu alors que les travaux « cosmétiques » sont engagés.Côté SVR-Lazartigue, Tom Laperche revient sur la frustration des 5 tentatives hivernales de Trophée Jules Verne et les enseignements tirés en matière de fiabilisation. De nouveaux appendices sont attendus. Il se confie aussi sur sa découverte du mode record… un challenge auquel Anthony Marchand se frotterait bien avec sa nouvelle machine.Après trois années passées aux côtés de François Gabart, ou Pascal Bidégorry, Tom Laperche raconte son tandem avec l'expérimenté Franck Cammas : le vainqueur de la Solitaire du Figaro 2022 espère bien tirer profit de son expérience récente sur la Coupe de l'America en termes de développement et d'innovation.Les deux hommes se projettent enfin sur la Transat Café l'Or (départ le 26 octobre du Havre). Si Anthony Marchand reste mystérieux sur l'identité de son co-skipper, il concède qu'un profil navigateur / routeur a retenu toute son attention, au regard des règles désormais en vigueur (pas de routage depuis la terre). Après ses deuxièmes places en 2021 et 2023, Tom Laperche rêve quant à lui de victoire en 2025 avec des arrivées d'Ultim « dans le même quart d'heure en Martinique ! ».Présenté par la Classe Imer

Las manchas en la piel son una de las inquietudes más frecuentes. En este sexto episodio de "A GUSTO EN MI PIEL” by SVR, nos sumergimos en el mundo del melasma y las diferentes formas de hiperpigmentación. ¿Qué son exactamente? ¿Cómo se clasifican? ¿Qué tratamientos existen para ellas? ¿Es posible prevenirlas eficazmente? Para abordar este tema, nos acompaña la dermatóloga Mar Luque Luna, quien despejará todas las dudas y ofrecerá consejos prácticos para mantener una piel uniforme y saludable. Con Néstor Amorín, del equipo SVR, liderando esta charla, descubriremos cada detalle sobre estas alteraciones en la pigmentación. Y, como no podía faltar, en nuestra sección habitual “Desmontando Mitos”, Beatriz Garde, Farmacéutica y Training Manager de SVR, pondrá a prueba las creencias más populares sobre el cuidado de la piel. ¿Los confirmamos o simplemente… mitos son?

Vitalik outlines a roadmap for Ethereum L2 rollup security. Aave integrates Chainlink's SVR oracle. And the FDIC updates crypto activity guidelines. Read more: https://ethdaily.io/675

In this episode of The Underpowered Hour, hosts Steve Beres and Ike Goss discuss a variety of eclectic Land Rover-related topics. Steve highlights Canada's new Gaia Range Rover, SVR and the debut of the Range Rover London Collection in British Columbia. The duo also covers Land Rover's significant investment in a Portland, Oregon tech hub for autonomous vehicles. Ike announces his purchase of an Austin Healy 3000 and their humorous speculations on the car's condition. They also take a look at intriguing listings on Bring a Trailer, including a unique Suzuki Jimny and a hybrid Series 3/Defender Land Rover. Tune in for these updates and more on Land Rover news and adventures.https://media.landrover.com/en-us/news/2025/03/range-rover-london-collection-makes-debut-range-rover-house-whistlerhttps://bringatrailer.com/listing/1999-suzuki-jimny/

Hannah und Fred besprechen den zweiten Teil des Jahresgutachtens des SVR-Wirtschaft.

Hannah und Fred besprechen die ersten 2 Kapitel des Jahresgutachtens des SVR Wirtschaft.

Colorado election officials downplay a partial password leak. Over 22,000 CyberPanel instances were targeted in a ransomware attack. Google issues a critical security update for Chrome. Microsoft says Russia's SVR is conducting a wide-ranging phishing campaign. The FakeCall Android banking trojan gains advanced evasion and espionage capabilities. A New 0patch Fix Blocks Malicious Theme Files. iOS malware LightSpy adds destructive features. LinkedIn faces class-action lawsuits over alleged privacy violations. The U.S. charges a Russian national as part of Operation Magnus. On this week's CertByte segment, Chris Hare is joined by Dan Neville to break down a question targeting the Certified Associate in Project Management (CAPM)® certification. An Ex-Disney Staffer Allegedly Adds a Side of Sabotage to Park Menus.  Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CertByte Segment In this segment, Chris is joined by an N2K Content Developer to help illustrate the learning. This week, Chris is joined by Dan Neville to break down a question targeting the Certified Associate in Project Management (CAPM)® certification by the Project Management Institute®. Today's question comes from N2K's PMI® Certified Associate in Project Management (CAPM®) Practice Test. If you're studying for a certification exam, check out N2K's full exam prep library of certification practice tests, practice labs, and training courses by visiting our website at n2k.com/certify. To get the full news to knowledge experience, learn more about our N2K Pro subscription at https://thecyberwire.com/pro. Please note: The questions and answers provided here, and on our site, are not actual current or prior questions and answers from these certification publishers or providers. Additional sources: The 9 Most In-Demand Professional Certifications You Can Get Right Now Selected Reading Partial Breach of Election Machine Passwords in Colorado Poses No Risk, State Says (The New York Times) Election Threats Escalating as US Voters Flock to the Polls (BankInfo Security) Massive PSAUX ransomware attack targets 22,000 CyberPanel instances (Bleeping Computer) Critical Chrome Security Update: Patch for Out-of-Bounds & WebRTC Vulnerability (Cyber Security News) Russian spies use remote desktop protocol files in unusual mass phishing drive (The Register) FakeCall Android Trojan Evolves with New Evasion Tactics and Expanded Espionage Capabilities (SecurityWeek) 0patch Blog: We Patched CVE-2024-38030, Found Another Windows Themes Spoofing Vulnerability (0day) (0patch) Recent Version of LightSpy iOS Malware Packs Destructive Capabilities (SecurityWeek) Lawsuits Accuse LinkedIn of Tracking Users' Health Info (GovInfo Security) Feds name a Russian accused of developing Redline (The Register) Fired Employee Allegedly Hacked Disney World's Menu System to Alter Peanut Allergy Information (404 Media) Share your feedback. We want to ensure that you are getting the most out of the podcast. Please take a few minutes to share your thoughts with us by completing our brief listener survey as we continually work to improve the show.  Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © N2K Networks, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices

Spycraft utilizes psychology more than gadgets. Ex-CIA officer Andrew Bustamante reveals the human side of intelligence gathering and deception. [Pt. 2/2 — find Pt. 1 here!] What We Discuss with Andrew Bustamante: The psychology of espionage and the process of recruiting assets, with an emphasis on the importance of building relationships and trust. The CIA uses a process called SADRAT (Spot, Assess, Develop, Recruit, Handle, and Terminate) to develop intelligence sources, which is similar to sales techniques and relationship building. The concept of public, private, and secret lives, highlighting how understanding and accessing someone's secret life is crucial for intelligence work. The strengths and operational styles of the CIA, Russia's SVR, Israel's Mossad, and China's MSS. Anxiety, often viewed negatively in society, can be a valuable asset in intelligence work and other high-performance fields. By reframing anxiety as a potential superpower, individuals can harness its benefits to drive success in their personal and professional lives. And much more — be sure to check out part one of this conversation here if you haven’t already! Full show notes and resources can be found here: jordanharbinger.com/1065 If you love listening to this show as much as we love making it, would you please peruse and reply to our Membership Survey here? And if you're still game to support us, please leave a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally! This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Subscribe to our once-a-week Wee Bit Wiser newsletter today and start filling your Wednesdays with wisdom! Do you even Reddit, bro? Join us at r/JordanHarbinger!

Michael Myers of The Sound Factory returns to discuss the Tuner Challenge at SVR and WCA Finals, as well as the ECA Finals, and some of his plans as the director of ECA. If there are topics or people you'd like to hear over the coming season, please do us a favor and submit them here: https://forms.gle/hz9GsfrZxn92r9qLA Many thanks to ResoNix Sound Solutions for supporting the SQOLOGY Podcast. You can find out more about Resonix Sound Treatment Solutions, along with tons of other info and products, at https://resonixsoundsolutions.com

Tonight's First Guest WeatherBrain is a NWS meteorologist at Rapid City, SD who turned a childhood fear of thunderstorms into a career focused on public safety, with experience in forecasting and research.  Keith Sherburn, welcome to the show. Last but certainly not least, our Second Guest WeatherBrain on tonight's episode is a NWS meteorologist focused on protecting lives and property by communicating severe weather risks, serving as the Severe Weather Program Coordinator and Lightning Safety Expert for the NWS.  He holds a BS in meteorology from the University of Oklahoma and an MS in Emergency Management from Jacksonville State.  Aaron Treadway, it's great to see you on the show. Senior Vice President of WeatherCall Services Bruce Thomas also drops by later in the episode to discuss WeatherCall's products and services. WeatherCall delivers polygonal warnings on your smartphone and works with many Fortune 500 companies including cruise lines and pharmaceutical companies. Our email officer Jen is continuing to handle the incoming messages from our listeners. Reach us here: email@weatherbrains.com. Tulsa breaks June record with 118F Heat Index (01:00) NOAA Pathways Program (12:30) Ernest P Hollings Undergraduate Scholarship (14:45) Improving the severe weather warning process/Current warning paradigm issues (26:10) NWS Community-centric warnings (27:00) Convective Warning Mutual Aid (47:30) AI/automation and weather forecasting (52:00) Reducing number of SVR warnings/FAR (01:10:30) 6/25 Unwarned Nebraska tornado (01:32:00) Updated lightning death statistics (01:52:00) WeatherCall NexGen (01:53:45) The Astronomy Outlook with Tony Rice (01:44:45) This Week in Tornado History With Jen (Jen is out this week) National Weather Round-Up (02:03:00) E-Mail Segment (Jen is out this week) and more! Web Sites from Episode 963:   WeatherCall Keith Sherburn on X Picks of the Week: Keith Sherburn  - AMS BOGM YouTube Page Aaron Treadway - "Isaac's Storm: A Man, A Time, and the Deadliest Hurricane in History" by Erik Larson James Aydelott - NOAA Aircraft Operations Center on X: Into the eye of Hurricane Beryl Jen Narramore - Out Rick Smith - Out Neil Jacobs - Out Troy Kimmel - Aviation Weather Center Kim Klockow-McClain - Hurricane Epsilon Discussion from December 2005 Bill Murray - Tropical Tidbits James Spann - Phillip Klotzbach on X The WeatherBrains crew includes your host, James Spann, plus other notable geeks like Troy Kimmel, Bill Murray, Rick Smith, James Aydelott, Jen Narramore, Dr. Neil Jacobs, and Dr. Kim Klockow-McClain. They bring together a wealth of weather knowledge and experience for another fascinating podcast about weather.

This week we talk about Linux, backdoors, and the Open Source community.We also discuss CPU usage, state-backed hackers, and SSH.Recommended Book: The Underworld by Susan CaseyTranscriptIn the world of computers, a "backdoor" is a means of accessing a device or piece of software via an alternative entry point that allows one to bypass typical security measures and often, though not always, to do so in a subtle, undetected and maybe even undetectable manner.While backdoors can be built into hardware and software systems by the companies that make those devices and apps and bits of internet architecture, and while some governments and agencies, including the Chinese government, and allegedly folks at the NSA, have at times installed backdoors in relevant hardware and software for surveillance purposes, backdoors are generally the domain of tech-oriented criminals of various stripes, most of whom make use of vulnerabilities that are baked into their targets in order to gain access, and then while inside the administration components of a system, they write some code or find some kind of management lever meant to give the company or other entity behind the target access for non-criminal, repair and security purposes, and that then allows them to continue to gain access in the future; like using a rock to prop open a door.Concerns over a backdoor being installed in vital systems is fundamental to why the US and European governments have been so hesitant to allow Chinese-made 5G hardware into their wireless communication systems: there's a chance that, with the aid, or perhaps just at the prodding of the Chinese government, such hardware, or the software it utilizes, could contain a Trojan or other packet of code, hidden from view and hardcoded into the devices in some covert manner; these devices could also harbor even smaller devices, indistinguishable from hardware that's meat to be there, that would allow them to do the same via more tangible means.Though there were almost certainly other economic and technology-dominance reasons for the clampdown on products made by Chinese tech company Huawei beginning in earnest in 2012, and escalating rapidly during the US Trump administration, that process was at least ostensibly tied to worries that a Chinese company, prone to spying and stealing foreign tech, already, might incorporate itself into fundamental global communication infrastructure.It was underpricing everybody else, offering whizbang new high-end 5G technology at a discount, and supposedly, if the accusations are true, at least, doing so as part of a bigger plan to tap into all sorts of vital aspects of these systems, giving them unparalleled access to all communications, basically, but also giving them the ability, supposedly, to shut down those systems with the press of a button in the event that China wants or needs to do so at some point, if they ever decide to invade Taiwan, for instance, and want to distract the Western world until that invasion is complete, or just make rallying a defense a lot more difficult.Other, confirmed and successfully deployed backdoors have been found in all sorts of products, ranging from counterfeit Cisco network products, like routers and modems, some of which were installed in military and government facilities back in 2008 before they were recognized for what they were, to Microsoft software, Wordpress plugins, and a brand of terminals that manage the data sent along fiber-optic cables, mostly for high-speed internet purposes.Again, in some cases, the entities making these products sometimes do install what are literally or essentially backdoors in their hardware and software because it allows them to, for instance, help their customers retrieve lost passwords, fix issues, install security updates, and so on.But backdoors of any shape or size are considered to be major security vulnerabilities, as stealing a password or getting access to a vital terminal could then grant someone with bad intentions access to absolutely everything, giving them god-like control over all aspects of a customer's information and operations, or maybe all of the company's customer's information and operations, and that creates a single point of failure that most companies want to avoid, because at a certain point there's no real way to prevent a truly determined and well-funded foe if they know the payout for investing in accessing that terminal or getting that password would be that substantial.What I'd like to talk about today is a long-term effort to do exactly that, the target, in this case, being small, but the potential payoff of backdooring it being pretty much as big as you can imagine.—XZ Utils is the name of an Open Source data compression utility, which means that it squishes data in such a way that no information is lost, but so that big files and other packets of information become smaller, and that makes it faster and easier and cheaper to send that data from place to place.XZ is popular in part because it's effective, in many cases outperforming other free alternatives, like gzip and bzip2, but it also supports an older compression model called LZMA, and it exists in the public domain, which means it's incredibly inexpensive to use, free, for most purposes.It's especially popular in Linux and other Unix-like systems, and in practice that means it's used across these systems so that when data is moved from place to place, it's compressed and decompressed, putting less pressure on the systems themselves, almost like reducing the weight of everything you have to carry throughout the day, without any reduction in quality or the nature of those books and bags and laptops and other things you're hauling around all the time; even small reductions in that weight could make a big difference in the strain on your body, over time, and this utility accomplishes the same for the systems that incorporate it.So this software utility is super useful, is free to anyone who wants to use it, and it's better than a lot of other options, and it's thus been baked into a bunch of fundamental computer infrastructure, like most Unix-like systems. And that's important for a lot of reasons, but the most immediately concerning issue is that the vast majority of servers that run the tech world—basically all the major tech companies, and all the companies they work with—manage their services with Linux.XZ isn't just important for folks who have laptops running on Linux, then, it's also vital to the functionality of huge chunks of the internet; stats from the past few years show that about 96.3% of the top million web sites run on Linux servers, and a substantial amount of non-web-serving servers do, as well.All of which sets the stage for the hubbub that arose on March 29, 2024, when a Microsoft employee named Andres Freund announced that, after looking into a decrease in performance in a version of Linux called Debian—a distinction between how fast it should have been going and how fast it was going of about 500 milliseconds, and that minor slowdown bugged him enough to look into what newer, experimental versions of XZ Utils were doing to the Debian operating system he was working with—after looking into that issue, he announced that he had discovered a backdoor in XZ that was causing errors in a memory debugging tool built into the software, and using more CPU power than Debian otherwise would have used.So he announced this discovery, reported it to an open source security mailing list, to make it known amongst the right people, and that alerted the folks who were experimentally incorporating this new build of XZ into their software.As it turns out, this backdoor, had it been implemented in all this software and spread across the servers that manage the web, would have granted whomever had access to it the ability to alter the behavior of the local instance of the Secure Shell Protocol, or SSH, which is what protects servers while they operate on open networks like the internet.The degree to which this would have damaged the web, as it exists today, cannot be overstated. This problem was given a Common Vulnerability Scoring System ranking, which rates the alarmingness of software issues based on how much damage they could potentially cause, which helps computer security professionals figure out which problems to address first, a score of 10, which is the highest possible score.In theory, this would have granted the person or other entity with backdoor access the ability to get into essentially any server touching the internet with full administrator privileges, making all that information transparent to them, providing them all information about users, passwords, banking information, everything everyone has ever posted to social media, private communications, research and technology secrets—it's really just boggling thinking about how much damage could have been caused by the right person or people, as such a backdoor would basically do away with most of the security measures they might encounter while attempting to infiltrate and even take over pretty much anyone.Because it was discovered by Freund, though, and because he got word out to the right people as quickly as he did, the cybersecurity world was able to pivot pretty quickly, advising everyone who had implemented these test versions to roll back to earlier versions of the relevant software, and the folks behind XZ quickly released updated versions of the utility that removed the backdoor problem.This also triggered a response in the wider software world as many developers have started to reduce the damage future, similar backdoors would be able to cause by reducing the connections and dependencies it took advantage of to function.So this was a big enough deal that even something as arcane as compression utilities and SSH became front-page news around the world, but arguably one of the most interesting aspects of this story is what we know about the person or people who seem to have installed this backdoor.Someone, or group of someones, going by the name Jia Tan, alongside an array of sock puppet accounts—fake accounts with different names that they also managed—started to contribute to the maintenance and development of this project, which is common in the open source world; that's part of what makes open source software and systems so powerful and desirable, despite often not having much in the way of funding or official support from big-name companies; they're often passion projects maintained by maybe just one or a few or a handful of dedicated developers.In 2021, this entity that became known as Jia Tan started contributing to open source projects, and then contributed a patch to XZ via its mailing list.Around that same time, several people who hadn't been seen in this project's community, previously, started to complain that it wasn't being updated fast enough, and arguing that another maintainer should be brought on board, to help it move along faster.This Jia Tan character then started making a lot more contributions to the project, all of them seemingly innocuous and helpful, though in retrospect at least one of them changed a function that would have detected the more malicious changes they ultimately submitted, later.In February of 2024, Tan submitted changes for the new version of XZ Utils that incorporated a backdoor, and groups of people in this larger open source community, possibly sock puppet accounts, started telling the developers who run Debian, Ubuntu, and Red Hat, all popular versions of Linux, they should incorporate this new version with those backdoor-incorporating changes into their operating systems.There are strong suspicions, but little evidence, at this point at least, that Jia Tan and those other sock puppet accounts were run by a well-funded and skilled, probably government-backed hacking group, like one of the entities that often work as proxies for Russia's SVR—their intelligence agency that tends to support local hacking groups to do this sort of dirty work; though again, we can't say that with any certainty, as a lot of government-backed hacking groups could pull off something like this, with enough patience, years worth of patience, and it's still possible that this was a single hacker seeing a soft-target and the potential for a huge payoff if it all worked out.That said, because of the approach this threat actor, whomever they actually are, took to target this utility, and because of how close they got to doing what they intended to do, which would have been devastating, probably even world-changing in some ways, the relationship that big tech and governance has with the open source world is being reassessed, because often the folks running these projects are just individual people doing all this important work in their free time. But because of how the tech world has evolved, huge swathes of the internet and other vital infrastructure are reliant on these single-person, passion-projects that are potential targets for cooption or, as seems to have been the case here, using what's called social engineering to manipulate the folks behind these projects, which can then gives more access to all the stuff they manage, and thus, the things that rely on the stuff they manage, to entities that want to cause harm.Again, and this cannot be emphasized enough, we just barely dodged a bullet here, and the only thing that prevented a huge amount of potential destruction was the effort of another single person who was, almost on a whim, hacking away on a little problem they wanted to look into, and who thus stumbled upon this issue right before it reached a scale that would have been truly problematic.And all of these issues were arguably the result of someone who found themself in the position of maintaining, more or less solo, a utility that became vital to global cybersecurity, and which thus made them the target of a sophisticated social engineering campaign.Show Noteshttps://en.wikipedia.org/wiki/Backdoor_(computing)https://en.wikipedia.org/wiki/Hardware_backdoorhttps://en.wikipedia.org/wiki/Social_engineering_(security)https://www.zdnet.com/article/linux-has-over-3-of-the-desktop-market-its-more-complicated-than-that/https://arstechnica.com/security/2024/04/what-we-know-about-the-xz-utils-backdoor-that-almost-infected-the-world/https://research.swtch.com/xz-timelinehttps://research.swtch.com/xz-scripthttps://news.ycombinator.com/item?id=39895344https://www.runtime.news/sabotage-in-the-software-supply-chain/https://news.ycombinator.com/item?id=39903685https://www.theverge.com/2024/4/2/24119342/xz-utils-linux-backdoor-attempthttps://www.wired.com/story/jia-tan-xz-backdoor/https://www.404media.co/xz-backdoor-bullying-in-open-source-software-is-a-massive-security-vulnerability/https://www.nytimes.com/2024/04/03/technology/prevent-cyberattack-linux.htmlhttps://www.economist.com/science-and-technology/2024/04/02/a-stealth-attack-came-close-to-compromising-the-worlds-computers This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe

LockBits reawakening. China's ramp up to safety for vital sectors. Data leak leaves China feeling exposed. Malware hidden by North Korea in fake developer job listings. UK Watchdog rebukes firm for biometric scanning of staff at leisure centers. SVR found adapting for the cloud environment. DOE proposes cybersecurity guidelines for the electric sector. Wideness of breach in the financial industry revealed. Moving on to better things. Things are looking up in the cybersecurity startup ecosystem. UK's National Cyber Security Centre announced they are launching a Cyber Governance Training Pack for boards. N2K's President Simone Petrella talks with Elastic's CISO Mandy Andress about the CISO role and the intersection of cybersecurity, law, and organizational strategy. And, there's a facial recognition battle going on at Waterloo, the University of Waterloo that is.  Remember to leave us a 5-star rating and review in your favorite podcast app. Miss an episode? Sign-up for our daily intelligence roundup, Daily Briefing, and you'll never miss a beat. And be sure to follow CyberWire Daily on LinkedIn. CyberWire Guest Simone Petrella, N2K's President, talks with Mandy Andress, Elastic's CISO, about the CISO role and the intersection of cybersecurity, law, and organizational strategy. Selected Reading LockBit Ransomware Gang Resurfaces With New Site (SecurityWeek) LockBit ransomware gang attempts to relaunch its services following takedown (The Record)  China to increase protections against hacking for key industries (Reuters) The I-Soon data leak unveils China's cyber espionage tactics, techniques, procedures, and capabilities. (N2K CyberWire) Fake Developer Jobs Laced With Malware (Phylum Blog) Data watchdog tells off outsourcing giant for scanning staff biometrics despite 'power imbalance' (The Register)  SVR cyber actors adapt tactics for initial cloud access (National Cyber Security Centre) New DOE-Funded Initiative Outlines Proposed Cybersecurity Baselines for Electric Distribution Systems (Energy.gov)  LoanDepot says about 17 million customers had personal data and Social Security numbers stolen during cyberattack (TechCrunch)  Actual filing to Office of Maine Attorney General: Data Breach Notifications - Consumer Protection (Maine.gov)  U-Haul data breach affects 67,000 customers in US and Canada (AZ Central) Actual filing to Office of Maine AG: Data Breach Notifications - Consumer Protection (Maine.gov)   Funding Down, Optimism Up: The Bright Spots For Cybersecurity Startups In 2024 (Forbes) NCSC to Offer Cyber Governance Guidance to Boards (InfoSecurity Magazine)  'Facial recognition' error message on vending machine sparks concern at University of Waterloo (CTV News)  Share your feedback. We want to ensure that you are getting the most out of the podcast. Please take a few minutes to share your thoughts with us by completing our brief listener survey as we continually work to improve the show.  Want to hear your company in the show? You too can reach the most influential leaders and operators in the industry. Here's our media kit. Contact us at cyberwire@n2k.com to request more info. The CyberWire is a production of N2K Networks, your source for strategic workforce intelligence. © 2023 N2K Networks, Inc. Learn more about your ad choices. Visit megaphone.fm/adchoices