POPULARITY
Categories
Medication safety remains a cornerstone of anesthesia practice with complex environments and high-stakes decisions requiring vigilant attention to prevent errors. This collaboration between APSF and OpenAnesthesia spotlights critical aspects of perioperative drug safety with practical insights from Dr. Juan Li, a cardiothoracic anesthesia fellow at Beth Israel Deaconess Medical Center.• Perioperative anaphylaxis requires immediate recognition of cardiovascular, respiratory, and cutaneous manifestations• Neuromuscular blocking agents and antibiotics represent common triggers for anaphylactic reactions• Preoperative assessment must include thorough allergy history, medication reconciliation, and identification of drug-drug interactions• Standardized drug concentrations, preparation methods, and equipment minimize medication errors• Technology integration through barcode readers and computerized decision support enhances safety• Pharmacy support with pre-mixed solutions and pre-filled syringes reduces preparation errors• Post-operative monitoring remains critical for catching delayed medication reactions• Safety culture should emphasize root cause analysis rather than punishment for medication errors• Implementation of standard protocols is essential for managing new medications with limited safety dataVisit APSF.org and Openanesthesia.org for detailed information and resources on medication safety in anesthesia practice.
The anterior talofibular ligament (ATFL) and the Achilles tendon captures much of our ankle attention. As JOSPT Insights listeners know, there's plenty more to the ankle than the ATFL. Today, Liz Bayley shares her approach to diagnosing, managing and ideally, preventing ankle pain in active people. Liz covers diagnosing the problem, where imaging fits, and how to support return to function, including high-level sport. Liz is a former professional dancer, who now works as a dance-specialist physiotherapist. Her clinic is in London's West End, in close proximity to the freelance professional and student dancers she works with, at Trinity Laban Conservatoire of Music and Dance, and on 'Matilda The Musical' in Covent Garden. ------------------------------ RESOURCES Lateral ankle ligament sprains clinical practice guideline: https://www.jospt.org/doi/10.2519/jospt.2021.0302 Updated model of chronic ankle instability: https://pubmed.ncbi.nlm.nih.gov/31162943/ Predictors of chronic ankle instability: https://pubmed.ncbi.nlm.nih.gov/26912285/ Intrinsic foot muscle training systematic review: https://pubmed.ncbi.nlm.nih.gov/35724360/ Neuromuscular electrical stimulation for foot intrinsic muscles: https://pubmed.ncbi.nlm.nih.gov/35142810/
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Advancing Neuromuscular Care and Research," former FDA commissioner Robert Califf, MD, explored the urgent need for sustained NIH funding to advance basic and translational research, including gene editing, assistive devices, and the integration of artificial intelligence. He emphasized the collaborative spirit of the neuromuscular community, where shared technologies and insights can address multiple disorders. The conversation, which took place at the 2025 Muscular Dystrophy Association (MDA) Clinical & Scientific conference, highlighted critical challenges, such as clinician shortages, healthcare system strain, and the need for post-market learning to manage uncertainties with emerging therapies like gene therapy. Additionally, he called for innovative funding solutions to address the high costs of treatment, ensure equitable access, and maintain progress in neuromuscular care while fostering long-term health equity. Looking for more epilepsy discussion? Check out the NeurologyLive® neuromuscular clinical focus page. Episode Breakdown: 1:05 – Funding priorities for neuromuscular research and NIH support 1:55 – Role of gene editing, assistive devices, and AI in care 4:50 – Collaboration and togetherness of the neuromuscular community 6:35 – Considerations as new therapeutics emerge for neuromuscular disorders 8:05 – Funding solutions for equitable care Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
The March 2025 replay features four previously released episodes focused on peripheral neuropathy and radiculopathy. The episode begins with Dr. Anne Oaklander discussing the association between long COVID and the development of polyneuropathy affecting small-fiber axons. This is followed by another interview with Dr. Oaklander, where she shares key takeaways for clinicians regarding the management of small-fiber neuropathy. The third segment features Drs. Raymond Price and Brian Callaghan discussing practice guidelines for painful diabetic neuropathy. The episode concludes with Dr. Carmel Armon addressing the efficacy of epidural steroid injections in treating cervical and lumbar spinal stenosis and radiculopathies. Podcast Links: Peripheral Neuropathy and Prolonged COVID Relapsing-Remitting Immunotherapy Responsive SFN Practice Guidelines for Painful Diabetic Neuropathy Epidural Steroids for Cervical and Lumbar Radicular Pain and Spinal Stenosis Article Links: Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID Relapsing-Remitting Immunotherapy Responsive Small-Fiber Neuropathy Epidural Steroids for Cervical and Lumbar Radicular Pain and Spinal Stenosis Systematic Review Summary Disclosures can be found at Neurology.org.
MIT dem Körper arbeiten und nicht GEGEN ihn – das ist die Idee von zyklusorientiertem Training. Allerdings ist die Forschungslage verhältnismäßig dünn. Über Menstruation und Zyklusphasen wird in der Sportbubble nicht wirklich offen gesprochen. Zusätzlich schwierig: die persönliche Ausgangslage extrem individuell. Gleichzeitig wird in Medien und sozialen Netzwerken viel und fleißig über zyklusgerechtes Training, zyklusgerechte Ernährung und sogar zyklusgerechtes Arbeiten philosophiert. Wie kann man zyklusorientiert trainieren? Was bedeutet das eigentlich genau? Und warum ist das nicht nur für die Leistungsfähigkeit, sondern auch das Verletzungsrisiko entscheidend? Darüber sprechen wir mit unserem heutigen Gast Prof. Patrick Diel vom Institut für Kreislaufforschung und Sportmedizin, Abteilung molekulare und zelluläre Sportmedizin. Viel Spaß beim Hören! Sarwar, R., Niclos, B.B. & Rutherford, O.M. (1996). Changes in muscle strength, relaxa- tion rate and fatiguability during the human menstrual cycle. J Physiol, 493 ( Pt 1), 267-272. Petrofsky J., Al Malty A., Suh H.J. (2007). Isometric endurance, body and skin temperature and limb and skin blood flow during the menstrual cycle. Sci. Monit.13:CR111– CR117. Sung, E. (2012). Effects of menstrual cycle based-training on muscle strength, muscle volume and muscle cell parameters in women with and without oral contraception. Veröffentlichte Disseration, Ruhr-Universität Bochum. Abt, J. P., Sell, T. C., Laudner, K. G., McCrory, J. L., Loucks, T. L., Berga, S. L., & Lephart, S. M. (2007). Neuromuscular and biomechanical characteristics do not vary across the menstrual cycle. Knee Surgery, Sports Traumatology, Arthroscopy, 15(7), 901– 907. doi:10.1007/s00167-007-0302-3. Birch, K., Reilly, T. (2002). The diurnal rhythm in isometric muscular performance differs with eumenorrheic menstrual cycle phase. Chronobiol Int 19(4):731–742. Janse de Jonge, X. A. K. (2003). Effects of the Menstrual Cycle on Exercise Performance. Sports Medicine, 33(11), 833–851.doi:10.2165/00007256-200333110-00004 Montgomery, M. M., & Shultz, S. J. (2010). Isometric Knee-Extension and Knee-Flexion Torque Production During Early Follicular and Postovulatory Phases in Recreatio- nally Active Women. Journal of Athletic Training, 45(6), 586593.doi:10.4085/1062- 6050-45.6.586 The influence of a vegan diet on body composition, performance and the menstrual cycle in young, recreationally trained women– a 12-week controlled trial Fierce Run Force Laufverein – Steffi PLatt Fragenbogen von Matthias Rißmayer zu RED-S: Es werden noch Teilnehmer gesucht. Teilnehmende bekommen sofort eine automatisierte Auswertung ihrer Ergebnisse. Weitere Informationen: www.dshs-koeln.de/einerundemit Redaktion und Produktion: Theresa Templin & Julia Neuburg, Abteilung Presse und Kommunikation, Deutsche Sporthochschule Köln, Moderation: Jan-Hendrik Raffler
Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Bimaje Akpa, MD Clinical practice guidelines from the American College of Chest Physicians provide recommendations for managing respiratory complications in patients with neuromuscular diseases, which can help inform our evaluation and treatment decisions. Joining Dr. Charles Turck to break down key insights from the CHEST guidelines and their impacts on clinical practice is Dr. Bimaje Akpa. Dr. Akpa is an Assistant Professor of Medicine in the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine at the University of Minnesota.
Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Jason Ackrivo, MD, MSCE Respiratory complications are fairly common in patients with neuromuscular disorders, and given their vast impacts on a patient's prognosis and quality of life, it's critical to proactively detect and monitor any signs of respiratory decline. To learn more about the symptoms, impacts, and diagnosis of respiratory complications in patients with neuromuscular disorders, Dr. Charles Turck speaks with Dr. Jason Ackrivo. Not only is Dr. Ackrivo the Associate Director of the Fishman Program for Home Assisted Ventilation, but he's also an Assistant Professor of Medicine in Pulmonary, Allergy, and Critical Care at the Hospital of the University of Pennsylvania.
In this episode with Melinda Smith, we discuss a recent article looking at the effect of kinesiotape vs low-dye tape for plantar fasciitis pain. We discuss:The differences in outcomes between these two groupsIndividual patient preferences Neuromuscular responses to taping
Host: Charles Turck, PharmD, BCPS, BCCCP Guest: Hank Mayer, MD Patients with neuromuscular conditions often exhibit respiratory symptoms that impact their airway clearance and gas exchange, making it increasingly difficult for them to breathe. However, effective assessment techniques and early intervention can help mitigate the progression of this dysfunction, potentially keeping patients from needing extended recovery time or even inpatient care. Joining Dr. Charles Turck to discuss the importance of informed, proactive intervention for respiratory symptoms in patients with neuromuscular conditions is Dr. Hank Mayer. Dr. Mayer is the Medical Director of the Pulmonary Function Laboratory at the Children's Hospital of Philadelphia and a Professor of Clinical Pediatrics at the University of Pennsylvania's Perelman School of Medicine.
In this episode Dr. Zachary Mang discusses his article, “A Discussion of the Combined Effect of Resistance Training and Time-Restricted Eating on Body Composition and Neuromuscular Adaptations” published in issue 47-1 of Strength and Conditioning Journal.
In this episode we will discuss Myasthenia Gravis, an Autoimmune Disease affecting the neuromuscular system of the body with Tasha White, Director of a new Non-profit organization called My Walk with MG located in St. Louis, MO. Myasthenia gravis is a chronic neuromuscular disease that causes weakness in the voluntary muscles. Voluntary muscles include muscles that connect to a person's bones, muscles in the face, throat, and diaphragm. They contract to move the arms and legs and are essential for breathing, swallowing and facial movements. Myasthenia gravis is an autoimmune disease, which means that the body's defense system mistakenly attacks healthy cells or proteins needed for normal functioning. The onset of the disorder may be sudden. Symptoms may not be immediately recognized as myasthenia gravis. The degree of muscle weakness involved varies greatly among individuals.
Analizamos si las cinco estrategias de recuperación más populares funcionan para acelerar la recuperación: masajes, pistolas de masaje, foam rollers, prendas compresivas, electro-estimulación. Nos apoyamos en cinco revisiones de estudios recientes: The Effects of Massage Therapy on Sport and Exercise Performance: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/37368560/ The Effects of Massage Guns on Performance and Recovery: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/37754971/ Effects of foam rolling on performance and recovery: A systematic review of the literature to guide practitioners on the use of foam rolling https://pubmed.ncbi.nlm.nih.gov/32507141/ Compression Garments and Recovery from Exercise: A Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/28434152/ Neuromuscular electrical stimulation during recovery from exercise: a systematic review https://pubmed.ncbi.nlm.nih.gov/24552796/ Si te ha gustado, suscríbete, ponle un Like, comenta, comparte. Gracias ! Sígueme en https://www.instagram.com/correrporsenderos/ donde publico píldoras sobre trail running y deporte endurance a diario en Stories . Puedes mandarme un MD por ahí para plantear dudas o sugerencias. Suscríbete a mi canal YouTube para ver estas explicaciones con apoyo visual: https://www.youtube.com/@C0rrerP0rSender0s Puedes ver mis entrenamientos en Strava: https://www.strava.com/athletes/93325076 --- #running #endurancetraining #recovery #fisioterapia #rendimiento #maraton
In this AANEM podcast, Dr. Andrés De León interviews neuromuscular pathology experts Dr. Aziz Shaibani and Dr. Marcus Pinto about the current state and value of muscle and nerve biopsies in clinical practice. The discussion covers essential topics including proper indications for biopsies, technical considerations in choosing biopsy sites, staining techniques, and the impact of advancing genetic testing on diagnostic approaches. Dr. Shaibani emphasizes that while genetic testing has reduced some muscle biopsy indications, biopsies remain crucial for certain conditions like inflammatory myopathies and mitochondrial disorders. Dr. Pinto details specific scenarios where nerve biopsies are invaluable, particularly in diagnosing vasculitic neuropathy and amyloidosis. Both experts share insights on the complementary role of muscle and nerve biopsies in conditions like systemic vasculitis and discuss how modern diagnostic tools like myositis antibody testing and genetic panels are changing but not eliminating the need for tissue diagnosis.
Neuromuscular electrical stimulation (NMES) hasn't quite had the coverage it deserves, especially when one considers the strength of evidence supporting NMES as a musculoskeletal rehabilitation intervention Today, Drs Elanna Arhos (Northwestern University) and Naoaki Ito (University of Wisconsin - Madison) are re-visiting how NMES is applied in sports clinical practice. Get the low-down on why you need NMES in your sports rehabilitation toolkit, and how to figure out dose and intensity. In part 2 we discuss how to support patients to get the most out of NMES, and which equipment is best for your clinic. ------------------------------ RESOURCES Who's afraid of electrical stimulation? Let's revisit the application of NMES at the knee: https://www.jospt.org/doi/10.2519/jospt.2023.12028
Send us a textToday, Bridget chats with neuromuscular massage therapist, Nicki Mercede. You'll learn about how we experience pain in the body and how discover the surprising ways that pain can present, as well as ways to address pain. If you have pain or cramping but aren't sure if it's strictly period-related, given that you have the pain throughout the month then this will be a good resource for you.Nicki's massage practice is located in San Diego. She practices craniosacral therapy, neuromuscular massage, and has a degree in medical massage. CONNECT WITH NICKIInstagram - @balancedbodywork.sd Website - www.massagebook.com/biz/nickimercedeCONNECT WITH BRIDGET Email listInstagramBook a free consult callWebsiteSUPPORT THIS PODCASTBuy Me a CoffeeRate & review the podShare it with your BFF
It Happened To Me: A Rare Disease and Medical Challenges Podcast
To celebrate our 50th episode we are honored to welcome Dr. Robert Bucelli on the show. He is a leading expert in neuromuscular neurology and a dedicated advocate for advancing treatments for neuromuscular disorders. In this episode, Dr. Bucelli shares his wealth of knowledge on neuromuscular neurology, exploring topics such as: What neuromuscular neurology entails and who is affected. The role of genetics in diagnosing and treating neuromuscular disorders. Common symptoms, risk factors, and diagnostic approaches. How therapies like physical and occupational therapy play a role in management. Lifestyle modifications, including diet and exercise, to minimize risk. The latest advancements in research and treatment, including ASO therapy. Strategies for coping with the challenges of living with neuromuscular conditions. Dr. Bucelli has been a practicing neurologist at the ALS Clinic since 2011. He is an Associate Professor of Neurology at the Washington University School of Medicine in St. Louis where he serves as the Site Principal Investigator on several clinical studies relating to ALS. After graduating summa cum laude from Canisius College in Buffalo, New York with a degree in biology, Dr. Bucelli went on to receive his medical degree and PhD from the State University of New York at Buffalo as part of the Medical Scientist Training Program. He then completed an internship in internal medicine and postgraduate residency in neurology at Barnes-Jewish Hospital and the Washington University School of Medicine, followed by a postgraduate Clinical Fellowship Training Program in the Department of Neurology's Neuromuscular Section, also at Barnes-Jewish and Washington University. He is also a graduate of the Washington University and Barnes-Jewish Hospital Academic Medical Leadership Program for Physicians and Scientists. Dr. Bucelli is expert in diagnosing and treating neuromuscular disorders including amyotrophic lateral sclerosis. He also reads and interprets muscle and nerve biopsies to aid in the diagnostic evaluations of patients seen at Washington University and many additional outside institutions. Dr. Bucelli's clinical expertise guides exemplary multidisciplinary ALS care in the neuromuscular clinic. His skill in delivering drugs to the fluid surrounding the spinal cord has enabled Dr. Bucelli's and Washington University's leadership in trials using to turn off the production of harmful genes that cause ALS. Dr. Bucelli has received numerous awards for excellence in teaching and clinical work at Washington University. He is a five-time recipient of the Eliasson Award for Teaching Excellence and has authored over 40 peer-reviewed manuscripts. He is a frequently invited guest lecturer and presenter at regional and national conferences. Stay tuned for the next new episode of “It Happened To Me” in the New Year on January 6th, 2025! In the meantime, you can listen to our previous episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “It Happened To Me”. “It Happened To Me” is created and hosted by Cathy Gildenhorn and Beth Glassman. DNA Today's Kira Dineen is our executive producer and marketing lead. Amanda Andreoli is our associate producer. Ashlyn Enokian is our graphic designer. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, ItHappenedToMePod.com. Questions/inquiries can be sent to ItHappenedToMePod@gmail.com.
In this AANEM podcast, Carrie Ford, a CNCT and R.NCS.T. from the University of Utah's Jack Pedegon EMG Lab, interviews Dr. Kyle Mahoney, an associate professor at the University of Utah, who provides a comprehensive explanation of neuromuscular junction transmission and the critical concept of the "safety factor." He breaks down complex neurophysiological concepts using accessible analogies, explaining how the safety factor serves as a built-in buffer that ensures reliable nerve-to-muscle signal transmission. The discussion covers normal neuromuscular junction function, the impact of various pathological conditions such as Lambert-Eaton Myasthenic Syndrome, myasthenia gravis, and ALS on neuromuscular transmission, and the clinical significance of repetitive nerve stimulation testing. Dr. Mahoney's clear explanations make these technically challenging concepts more approachable for healthcare professionals, particularly EMG technicians who may be less familiar with the underlying mechanisms of neuromuscular transmission.
The often challenging diagnosis of neuromuscular junction (NMJ) disorders can be explained by suspicious red flags for the key differential diagnoses (mimics) and atypical presentations (chameleons). In the latest Editor's Choice paper podcast, PN's podcast editor Dr. Amy Ross Russell interviews Dr Stephen Reddel and Dr Shadi El-Wahsh, both from the Concord Hospital, New South Wales, Australia, and the authors of Neuromuscular junction disorders: mimics and chameleons. Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production and editing by Letícia Amorim, Amy Ross Russell, and Brian O'Toole. Thank you for listening.
When they say you learn something new everyday, they weren't kidding! We learned enough in this one episode to get us through the next month, at least!It was our pleasure to have Summer Maiden as a guest to talk about the importance of lymphatic massages. We learned so much about the process and why lymphatic massages aren't just for post surgery or folks with lipedema or lymphedema. Lymphatic massages are actually recommended for everybody as a way to help rid yourself of toxins that need to drain from your body. It was all very interesting, and we suggest you listen and take notes on some of the info Summer shares. A little background on Summer... She graduated from the American Institute of Alternative Medicine in 2005. and is multi-state licensed. She has been an active licensed massage therapist for almost two decades, working with many clients. Her extensive training includes specialties in Swedish, Neuromuscular, Cranial-Sacral Therapy, Manual Lymphatic Drainage, Scar Tissue Release, Fertility and pre-/postnatal care, High-Risk Pregnancy care, Infant Massage Instructor, Neonatal Massage, Pelvic Floor Dysfunction, Breast Lymphatic Health, and MediCupping™. In addition to her clinical skills, she is an experienced Massage Therapy Educator, Anatomy and Physiology Instructor, and Business Coach. With a career that spans almost two decades, she has built a thriving private practice. She has worked in various settings, including physical therapy clinics, fitness centers, corporate wellness programs, doctor's offices, and hospitals. Upon transitioning to the Inpatient Massage Therapy Department within a local hospital, she specialized in Hematology/Oncology, Cardiac Intensive Care Unit (CTICU), Heart/Lung Transplant, Pulmonary Rehab, NICU, and Rehabilitation units, treating both adult and pediatric patients with diverse therapeutic needs. As a lymphatic drainage therapist, she provides massage to various post-surgical clients, those with autoimmune disorders, and those with general health issues for detoxification. Drawing on her experience working alongside physicians, she founded "My Kneads,” a practice focused on pain management, swelling/edema, inflammation, self-image, and confidence. She has released two new books called Flow & Thrive and Balanced Boobs.You can find Summer on Instagram @waze2wellness and @mykneads as well as her YouTube Podcast Waze2Wellness.Follow Justy & Steph on Instagram, where they share their weight loss journey and road to living a happy & healthy lifestyle.@we.are.losing.it If you prefer video to see us talk through our topics, you can watch us on YouTube. https://youtube.com/@wearelosingitShow your support by hitting download, like & subscribe! We truly appreciate each and every one of you!!
In this interview, Dr. Norrell provides key information about children with neuromuscular disorders, such as cerebral palsy, spina bifida, hereditary spastic paraplegia, chromosomal disorders, and children with gait abnormalities, such as toe-walking. This is great content for physical therapists, primary care physicians and neurologists who may be interested in having their patients evaluated for improved coordination and optimization of care.
In this AANEM podcast, Dr. Kelly Gwathmey interviews Dr. Aziz Shaibani and Dr. Yasser Hussain, two experienced neuromuscular specialists who run successful private practice clinical research programs in Texas. They discuss the motivations for conducting clinical trials, including expanding treatment options for patients and contributing to medical advancement. The experts share valuable insights about building research infrastructure, recruiting patients, managing competing trials, and balancing clinical duties with research responsibilities. They emphasize the importance of having well-trained research coordinators, efficient databases, and proper facility space. Both physicians stress the need for more clinical trial training in medical education and encourage young physicians to enter the field, noting that while only 5% of physicians participate in clinical trials, there are over 200,000 trials currently listed in the USA, presenting significant opportunities for new researchers.
Neuromuscular junction disorders can present in a variety of challenging ways, with the potential to mislead neurologists. Journal editors Prof. Philip Smith and Dr. Geraint Fuller begin with this subject as they talk through the latest issue Practical Neurology, for December 2024. The conversation moves to neck flexion and brain zaps, reflects on the undiminished importance of "general" neurology, and also touches on maternal epilepsy risks, frailty's impact on stroke patients, timely recognition of glaucoma, and sustainable practices for green physicians. To finish, there's the now-traditional recital of eponymous syndromes. Read the issue: https://pn.bmj.com/content/24/6 Please subscribe to the Practical Neurology podcast on your favourite platform to get the latest podcast every month. If you enjoy our podcast, you can leave us a review or a comment on Apple Podcasts (https://apple.co/3vVPClm) or Spotify (https://spoti.fi/4baxjsQ). We'd love to hear your feedback on social media - @PracticalNeurol. Production by Letícia Amorim and Brian O'Toole. Editing by Brian O'Toole. Thank you for listening.
Happy Halloween, and welcome to another chilling episode of the NAVAS podcast, where we venture into the eerie depths of veterinary anesthesia! Join us as we lift the curtain on a topic that, while vital to advanced anesthesia practice, often sends shivers down the spine of even the bravest veterinary professionals—neuromuscular blocking agents (NMBAs) in veterinary patients. While paralytic agents play an important role in providing excellent quality muscle relaxation that can help facilitate a variety of procedures, their use often spooks even the seasoned anesthetist, as they can cause frightening problems if not used with great care. After listening to this episode, we hope you can avoid a jump scare anytime you need to use NMBA. Our guest for this spine-tingling episode is the highly esteemed Dr. Daniel Sakai from the University of Georgia College of Veterinary Medicine. Dr. Sakai, boarded veterinary anesthesiologist, has conducted extensive research on NMBAs, exploring their invaluable role in patient immobilization as well as how to optimize recovery from neuromuscular blockade. He's here to help us demystify these powerful agents, dissect their practical applications, and reveal how to use them safely and effectively to prevent any nightmarish outcomes for your patients. So, as the leaves fall and the shadows lengthen, grab a cozy blanket, tune in, and get ready to learn from one of the top minds in veterinary anesthesia. Just be warned—this episode might leave you spellbound!If you like what you hear, we have a couple of favors to ask of you:Become a member of NAVAS for access to more anesthesia and analgesia educational and RACE-approved CE content.Spread the word. Share our podcast on your socials or a discussion forum. That would really help us achieve our mission: Reduce mortality and morbidity in veterinary patients undergoing sedation, anesthesia, and analgesia through high-quality, peer-reviewed education. Thank you to our sponsor, Dechra - learn more about the pharmaceutical products Dechra has to offer veterinary professionals, such as Zenalpha.If you have questions about this episode or want to suggest topics for future episodes, reach out to the producers at education@mynavas.org.All opinions stated by the host and their guests are theirs alone and do not represent the thoughts or opinions of any corporation, university, or other business or governmental entity.
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, Lawrence Robinson, MD, a senior scientist at Sunnybrook Research Institute, sat down to discuss his presentation from the 2024 American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) annual meeting, focused on educating the next generation of neuromuscular and electrodiagnostic (EDX) practitioners. Robinson gave an overview of his presentation, why this was a topic of interest, and the major differences in how this generation of medical students learn relative to previous ones. In addition, he discussed adapting to new learning styles, the benefits of flipped classrooms, and the impact of technology on education and practice. Furthermore, he touched upon the personal connections and humor in teaching, as well as ways to improve critical evaluation skills as a learner. Looking for more neuromuscular discussion? Check out the NeurologyLive® neuromuscular clinical focus page. Episode Breakdown: 1:05 – Overviewing and background on AANEM presentation 3:15 – Challenges with educating next generation of neuromuscular and EDX practitioners 4:40 – Areas of opportunity and growth for these next generation learners 5:50 – Neurology News Minute 8:00 – Novelty and advantages of flipped classroom approaches to teaching 10:10 – Future expected changes to neuromuscular care 11:55 – Final thoughts on care on NM and EDX education The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Phase 3 ENSURE Program of Vidofludimus Calcium Continues Following Positive Futility Analysis Gene Therapy FLT201 Shows Promise in Early-Stage Study of Gaucher Disease Risk of ARIA-E in Donanemab Attenuated Through New Enhanced Titration Method of Delivery Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
In this episode, we learn from Yogi Aaron about the importance of neurologically strong muscles and how to create them. You might be surprised to find out that stretching, as we typically think of it, is doing more damage than it is helping. Yogi Aaron created Applied Yoga Anatomy + Muscle Activation™ (AYAMA) as a technique to help us live pain free.Using movement to illicit a response from the muscles gives the proper feedback about how that muscle or group of muscles is operating. This is a key factor in addressing that body part's readiness for function. Pain, inflammation, or instability is a warning sign that typically leads to injury if ignored.A driving factor for Yogi Aaron is answering the question "what don't I know?" This has led him to be a trailblazer in the yoga and health world.To learn more please visit yogiaaron.com and follow him on Instagram @yogi_aaronAre ready to start living pain-free today? Sign up Yogi Aaron's FREE 7-day experience to heal your pain, get empowered, and discover your most vibrant life! Visit ConfidenceThroughHealth.com to find discounts to some of our favorite products.Follow me via All In Health and Wellness on Facebook or Instagram.Find my books on Amazon: No More Sugar Coating: Finding Your Happiness in a Crowded World and Confidence Through Health: Live the Healthy Lifestyle God DesignedProduction credit: Social Media Cowboys
What happens when common sense fails us? Or maybe doesn't tell us the whole story? Let me give you an example… I would assume if an athlete went out and played their most intense soccer match EVER, that they'd be more fatigued, which would increase their risk of injury, and/or would have poor force plate […] The post James Collins on Session RPE, Neuromuscular Fatigue, and the Science of Training Load in Soccer appeared first on Robertson Training Systems.
Send us a textWe continue our series targeted at people preparing for the internal medicine (IM) board and in-service exams. Today's topic: neuromuscular disorders!A challenging topic, but getting some basic frameworks down can make a huge difference!Topics covered include:Exam signs to help you localize in the peripheral nervous systemALSPeripheral neuropathyNeuromuscular junction disordersMyopathyand more! Check out our website at www.theneurotransmitters.com to sign up for emails, classes, and quizzes! Would you like to be a guest or suggest a topic? Email us at contact@theneurotransmitters.com Follow our podcast channel on
Do you CARE enough about your ATHELTES to try to LEARN more about their abilities, problems & POTENTIAL SKILL ISSUES
Paul Bruning, Service Line Director at Sutter Health, shares his insights on the evolving trends in neuromuscular skeletal care, the role of AI in healthcare, and the importance of patient-reported outcome measures in value-based care. He also discusses his career journey and offers advice for emerging healthcare leaders.
Chegou o momento do já tradicional episódio duplo sobre o IgNobel, que tem como missão "honrar estudos e experiências que primeiro fazem as pessoas rir e depois pensar", com as descobertas científicas mais estranhas do ano.Esta é a primeira de duas partes sobre a edição 2024 do prêmio, que teve como tema a "Lei de Murphy", com as categorias Biologia, Botânica, Anatomia, Medicina e Física.Confira no papo entre o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.> OUÇA (38min 13s)*Naruhodo! é o podcast pra quem tem fome de aprender. Ciência, senso comum, curiosidades, desafios e muito mais. Com o leigo curioso, Ken Fujioka, e o cientista PhD, Altay de Souza.Edição: Reginaldo Cursino.http://naruhodo.b9.com.br*REFERÊNCIASPRÊMIO DE BIOLOGIA [EUA]Fordyce Ely e William E. Petersen, por explodir um saco de papel ao lado de um gato que está em cima de uma vaca, para explorar como e quando as vacas expeliam seu leite.REFERÊNCIA: “Factors Involved in the Ejection of Milk,” Fordyce Ely e W.E. Petersen, Journal of Dairy Science, vol. 3, 1941.QUEM FOI À CERIMÔNIA: A filha de Fordyce Ely, Jane Ely Wells, e o neto Matt Wells.https://www.sciencedirect.com/science/article/pii/S0022030241954061/pdf?md5=abe9056326262861c49e6b9da0575ebd&pid=1-s2.0-S0022030241954061-main.pdfPRÊMIO DE BOTÂNICA [ALEMANHA, BRASIL, EUA]Jacob White e Felipe Yamashita, por encontrarem evidências de que algumas plantas reais imitam as formas de plantas artificiais de plástico próximas.REFERÊNCIA: “Boquila trifoliolata Mimics Leaves of an Artificial Plastic Host Plant,” Jacob White e Felipe Yamashita, Plant Signaling and Behavior, vol. 17, nº 1, 2022.QUEM FOI À CERIMÔNIA: Felipe Yamashita.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903786/Artigo extra: Vision in Plants via Plant-Specific Ocelli?https://www.sciencedirect.com/science/article/abs/pii/S1360138516300930PRÊMIO DE ANATOMIA [FRANÇA, CHILE]Marjolaine Willems, Quentin Hennocq, Sara Tunon de Lara, Nicolas Kogane, Vincent Fleury, Romy Rayssiguier, Juan José Cortés Santander, Roberto Requena, Julien Stirnemann e Roman Hossein Khonsari, por estudar se o cabelo na cabeça da maioria das pessoas no hemisfério norte gira na mesma direção (horário ou anti-horário?) que o cabelo na cabeça da maioria das pessoas no hemisfério sul.REFERÊNCIA: “Genetic Determinism and Hemispheric Influence in Hair Whorl Formation,” Marjolaine Willems et al., Journal of Stomatology, Oral and Maxillofacial Surgery, vol. 125, nº 2, abril de 2024.QUEM FOI À CERIMÔNIA: Marjolaine Willems e Roman Khonsari.https://www.sciencedirect.com/science/article/abs/pii/S2468785523002859Naruhodo #231 - Gêmeos têm a mesma impressão digital?https://www.youtube.com/watch?v=AH5LQPW4lbINaruhodo #113 - Por que as pessoas são destras ou canhotas?https://www.youtube.com/watch?v=spZjtr9FOmkPRÊMIO DE MEDICINA [SUÍÇA, ALEMANHA, BÉLGICA]Lieven A. Schenk, Tahmine Fadai e Christian Büchel, por demonstrar que medicamentos falsos que causam efeitos colaterais dolorosos podem ser mais eficazes do que medicamentos falsos que não causam efeitos colaterais dolorosos.REFERÊNCIA: “How Side Effects Can Improve Treatment Efficacy: A Randomized Trial,” Lieven A. Schenk et al., Brain, vol. 147, nº 8, agosto de 2024.QUEM FOI À CERIMÔNIA: Lieven Schenk.https://academic.oup.com/brain/article-abstract/147/8/2643/7664309?redirectedFrom=fulltextNaruhodo #309 - Por que sentimos medo? - Parte 1 de 2https://www.youtube.com/watch?v=xNwl26ZbVD8Naruhodo #310 - Por que sentimos medo? - Parte 2 de 2https://www.youtube.com/watch?v=cqkh5IdfQQMPRÊMIO DE FÍSICA [EUA]James C. Liao, por demonstrar e explicar as habilidades de natação de uma truta morta.REFERÊNCIAS: “Neuromuscular Control of Trout Swimming in a Vortex Street,” James C. Liao, The Journal of Experimental Biology, vol. 207, 2004;https://journals.biologists.com/jeb/article/207/20/3495/14915/Neuromuscular-control-of-trout-swimming-in-a“Passive Propulsion in Vortex Wakes,” David N. Beal et al., Journal of Fluid Mechanics, vol. 549, 2006.https://liaolab.com/wp-content/uploads/2020/10/2006Beal_etal.pdfQUEM FOI À CERIMÔNIA: James C. (“Jimmy”) Liao.Naruhodo #297 - Balançar de um lado para o outro ajuda a dormir melhor?https://www.youtube.com/watch?v=LvuqqtayK60*APOIE O NARUHODO PELA PLATAFORMA ORELO!Um aviso importantíssimo: o podcast Naruhodo agora está no Orelo: https://bit.ly/naruhodo-no-oreloE é por meio dessa plataforma de apoio aos criadores de conteúdo que você ajuda o Naruhodo a se manter no ar.Você escolhe um valor de contribuição mensal e tem acesso a conteúdos exclusivos, conteúdos antecipados e vantagens especiais.Além disso, você pode ter acesso ao nosso grupo fechado no Telegram, e conversar comigo, com o Altay e com outros apoiadores.E não é só isso: toda vez que você ouvir ou fizer download de um episódio pelo Orelo, vai também estar pingando uns trocadinhos para o nosso projeto.Então, baixe agora mesmo o app Orelo no endereço Orelo.CC ou na sua loja de aplicativos e ajude a fortalecer o conhecimento científico.https://bit.ly/naruhodo-no-orelo
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, Joanne Donovan, MD, PhD, chief medical officer at Edgewise Therapeutics, sat down to discuss the clinical program of EDG-5506, an investigational drug in development for Becker muscular dystrophy, and the recent progress in treating and understanding Becker muscular dystrophy. She spoke on the mechanism of action of the drug, also known as sevasemten, and why the company believes it can be therapeutically beneficial for this patient population. Furthermore, Donovan spoke on the previous failures in drug development for Becker, advances in biomarker detection, and how other trials paved the way for the company's phase 2 study and open label extension, dubbed CANYON (NCT05291091) and GRAND CANYON. Furthermore, she spoke on the ways the clinical community has tried to improve the quality of life for patients with Becker, focusing on approaches and tactics that curve cardiac issues commonly seen in this group. Looking for more Neuromuscular discussion? Check out the NeurologyLive® neuromuscular clinical focus page. Episode Breakdown: 1:15 – Overview of CANYON study and extension phase 3:50 – Mechanism of action of EDG-5506 6:30 – How previous trial experiences shaped CANYON 10:10 – Neurology News Minute 11:50 – Ongoing challenges with treating and testing drugs for Becker 15:25 – Safety profile of EDG-5506 16:45 – Ways to tackle cardiac issues in Becker The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Digital Therapeutic CT-132 Meets Primary End Point in Phase 3 Study of Preventive Migraine FDA Supports Alpha-Synuclein Seed Amplification Assay Biomarker for Clinical Trials in Parkinson Disease FDA Approves Subcutaneous Formulation of Ocrelizumab for Relapsing and Progressive Multiple Sclerosis Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
Many autoimmune neuromuscular disorders are reversible with prompt diagnosis and early treatment. Understanding the potential utility and limitations of antibody testing in each clinical setting is critical for practicing neurologists. In this episode, Teshamae Monteith, MD, FAAN speaks with Divyanshu Dubey, MD, FAAN, author of the article “Autoimmune Neuromuscular Disorders Associated With Neural Antibodies,” in the Continuum® August 2024 Autoimmune Neurology issue. Dr. Monteith is the associate editor of Continuum® Audio and an associate professor of clinical neurology at the University of Miami Miller School of Medicine in Miami, Florida. Dr. Dubey is an associate professor in the departments of neurology and laboratory medicine and pathology at the Mayo Clinic in Rochester, Minnesota. Additional Resources Read the article: Autoimmune Neuromuscular Disorders Associated With Neural Antibodies Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @headacheMD Guest: @Div_Dubey Transcript Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, which features conversations with Continuum's guest editors and authors who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article and have access to exclusive interviews not featured on the podcast. Please visit the link in the episode notes for more information on the article, subscribing to the journal, and how to get CME. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. Today, I'm interviewing Dr Divyanshu Dubey about his article on autoimmune neuromuscular disorders associated with neural autoantibodies, which is part of the August 2024 Continuum issue on autoimmune neurology. Welcome to the podcast. How are you? Dr Dubey: Hi, Dr Monteith. Thank you for inviting me to be a part of this podcast. I'm doing well. Dr Monteith: Well, why don't you introduce yourself to the audience? And, call me Tesha. Dr Dubey: I'm Divyanshu Dubey (please, call me Div). I'm one of the autoimmune neurology consultants here at Mayo Clinic Rochester. I'm an Associate Professor of neurology, as well as lab medicine and pathology. My responsibilities here are split - partly seeing patients (primarily patients with autoimmune disorders, including neuromuscular disorders), and then 50% of my time (or, actually, more than 50%), I spend in the lab, either doing research on these autoimmune disorders or reporting antibodies in a clinical setting for various antibody panels which Mayo's neuroimmunology lab offers. Dr Monteith: That's a nice overlap of subspecialty area. How did you get into this work? Dr Dubey: I think a lot of it was, sort of, by chance. Meeting the right people at the right time was the main, sort of, motivation for me. Initially, I trained in India for my medical school and didn't really got much exposed to autoimmune neurology in India. I think our primary concern in my training was sort of treating TB meningitis and cerebral malaria - that was my exposure to neurology, including stroke and some epilepsy cases. As a part of application for USMLEs and coming here to residency, I did some externships, and one of the externships was at Memorial Sloan Kettering Cancer Center, and that's when I worked a few weeks with Dr Posner and got introduced to the idea of paraneoplastic neurological syndrome working with him. And that sort of started - I wouldn't call it vicious cycle - but my interest in the area of autoimmune neurology and paraneoplastic neurological disorders, which subsequently was refined further through residency and fellowships. Dr Monteith: That's interesting. I actually rotated through - I did a externship also at Sloan Kettering, and I had a clinic with Dr Posner. And I thought, at the time, he was such a rock star, and, like, I took a picture with him, and I think he thought it was insane. And I didn't go into autoimmune neurology. So, you know, interesting pathways, right? Dr Dubey: Yes. And I think he's inspired many, many people, and sort of trained a lot of them as well. Dr Monteith: So, why don't you tell us what you set out to do when writing this article? Dr Dubey: So, I think, given my background and training in various subspecialties in neurology, I was, sort of, formally did fellowships in autoimmune neurology, as well as neuromuscular medicine. One of the areas in these areas that I focus on is in my clinical practice, as well as in my sort of lab work, is autoimmune muscular disorders - and that to, specifically, autoantibodies and their clinical utility for autoimmune muscular disorders. So, that's what I wanted to focus on in an article. When I was invited to write an article on autoimmune muscular conditions in general, I thought it was very difficult to pack it all in one chapter or one article, so I narrowed my focus (or tilted my focus) towards antibody-positive disorders and trying to understand how we as neurologists can firstly sort of identify these conditions (which may end up being antibody-positive) – and then, on the other hand, once we get these antibody results, how we can find the utility in them or find them useful in taking care of our patients. At the same time, I also wanted to kind of highlight that these antibodies are not perfect, they do have certain limitations – so, that's another thing I sort of highlighted in the article. Dr Monteith: So, why don't we just start with a very broad question - what do you believe the role of autoantibodies is in the workup of neuropathies and then neuromuscular disorders? Obviously, when we think of myasthenia gravis, but there are some presentations that you may not necessarily think to first order autoantibody tests. So, what is the role, and where does it fit in the paradigm? Dr Dubey: I think it's extremely crucial, and it's evolving as time goes on, and it's becoming more and more clinically relevant. Let's say three, four decades ago, the number of biomarkers which were available were very limited and only a handful - and there has been a significant increase in these biomarkers with growing utilization of newer techniques for discovery of antibodies, and more and more people jumping into this field trying to not only discover, but try and understand and validate these biomarkers (what they truly, clinically mean). These antibodies, like you pointed out, ones for myasthenia (such as acetylcholine receptor-binding antibodies, or MuSK antibodies), they can be extremely helpful in clinical diagnosis of these patients. We all know the importance of EMG in managing our patients with neuromuscular disorders. But, oftentimes, EMG nerve conduction studies are often not available at every center. In those scenarios, if you have antibodies with very high clinical specificity, and you're seeing a patient on examination whom you're seeing ptosis (fatigable ptosis), double vision, you're suspecting myasthenia, you send antibodies, and they come back positive. It brings you closer to the answer that may, in turn, require you to refer to a patient to a place where you can get high-quality EMGs or high-quality care. In addition to getting to the diagnosis, it also, sometimes, leads you in directions to search for what is the trigger. A good example is all these paraneoplastic neurological syndromes (which we started our conversation with), where once you find a biomarker (such as anti-Hu antibodies or CRMP5 antibodies) in a patient with paraneoplastic neuropathies, it can direct the search for cancer. These are the patients where, specifically, these two antibodies, small-cell lung cancer is an important cancer to rule out - they require CT scans, and if those are negative, consider doing PET scan – so, we can remove the inciting factor in these cases. And then, lastly, it can guide treatment. Depending upon subtypes of antibodies or particular antibodies, it can give us some idea what is going to be the most effective treatment for these patients. Dr Monteith: I think paraneoplastic syndromes are a very good example of how autoantibodies can help guide treatment. But, what other examples can you provide for us? Dr Dubey: Yeah, so I think one of the relatively recent antibody tests which our lab started offering is biomarkers of autoimmune neuropathies - these are neurofascin and contactin, and those are great examples which can target or guide your treatment. I personally, in the past, have had many CIDP patients before we were offering these testings, where we used to kind of start these patients on IVIG. They had the typical electrodiagnostic features, which would qualify them for CIDP. They did not show any response. In many of these cases, we tried to do sort of clinical testing or sort of research-based testing for neurofascin and contactin back in the day, but we didn't have this resource where we can sort of send the blood, hopefully, and within a week, get an answer, whether these patients have autoimmune neuropathy or not. Having this resource now, in some of these cases, even before starting them on IVIG, knowing that test result can guide treatments, such as considering plasma exchange up front as a first-line therapy, followed by rituximab or B-cell depleting therapies, which have been shown to be extremely beneficial in these conditions. And it is not just limited to neurofascin or contactin (which are predominantly IgG4-mediated condition), but the same concept applies to other IgG4-mediated diseases, such as MuSK myasthenia, where having an antibody result can guide your treatment towards B-cell depleting therapies instead of sort of trying the typical regimen that you try for other myasthenia gravis patients. Dr Monteith: And you mentioned where I was reading that, sometimes, nerve conduction studies and EMG can be useful to then narrow the autoantibody profiles. Oftentimes, in the inpatient service, we order the autoantibodies much faster, because it's sometimes harder to access EMG nerve conduction studies - but talk about that narrowing process. Dr Dubey: Yeah. And it goes back to the point you just made where we end up sending, sort of, sometimes (and I'm guilty of this as well), where we just send antibodies incessantly, even knowing that this particular patient is not necessarily likely to be an autoimmune neurological disorder, and that can be a challenge, even if the false-positive rate for a particular test is, let's say 1% - if you send enough panels, you will get that false-positive result for a particular patient. And that can have significant effects on the patient - not only unnecessary testing or imaging (depending on what type of antibody it is), but also exposure to various immunotherapies or immunosuppressive therapies. It's important to recognize red flags – and that's one of the things I've focused on in this article, is talking about clinical, as well as electrodiagnostic, factors, which make us think that this might be an autoimmune condition, and then, subsequently, we should consider autoantibody testing. Otherwise, we can be in a situation - that 1% situation - where we may be sort of dealing with a false-positive result, rather than a true-positive result. In terms of EMGs, I think I find them extremely useful, specifically for neuropathies, distinguishing between demyelinating versus exonal, and then catering our antibody-ordering practices toward specific groups of antibodies which are associated with demyelinating neuropathies (if that's what the electrophysiology showed) versus if it's an exonal pathology (considering a different subset of antibodies) - and that's going to be extremely important. Dr Monteith: You're already getting to my next question, which is what are some of the limitations of autoantibody testing? You mentioned the false-positivity rate - what other limitations are there? Dr Dubey: So, I think the limitations are both for seropositive, as well as seronegative, patients. As a neurologist, when we see patients and send panels, we can be in a challenging situation in both of those scenarios. Firstly, thinking about seropositives - despite the growing literature about neurology and antibodies, we have to be aware, at least to some extent, about what methodologies are being utilized for these antibody tests. And what I mean by that is knowing when you're sending a sample to a particular lab, the methodology that they're utilizing - is that the most sensitive, specific way to test for certain antibodies? We've learned about this through some of the literature published regarding MOG and aquaporin-4, which has demonstrated that these antibodies, which we suspect are cell surface antibodies, not only generate false-positive, but also false-negative results if they are tested by Western blots or ELISAs. Similar can be applied to some of the cell surface antibodies we are investigating on the autoimmune neuromuscular side (we have some sort of unpublished data regarding that for neurofascin-155). Secondly, it's also kind of critical when you're getting these reports to kind of have a look at what type of secondary antibodies are being utilized, an example being we talked about neurofascin-155, and I mentioned these are IgG4-predominant diseases, so testing for neurofascin IgG4 and knowing that particular patient is positive IgG4 rather than neurofascin pan-IgG. That's an important discrimination, and important information for you to know, because we have seen, at least in my clinical practice, that patients who are positive for neurofascin IgG4 follow the typical story of autoimmune neuropathies - the ones who are not (who are just neurofascin-155 IgG-positive), oftentimes can have wide-ranging phenotypes. The same applies to neurofascin-155 IgMs. And then (not for all antibodies, but for some antibodies), titers are important. A good example of that is a3 ganglionic receptor antibodies, which we utilize for when we're taking care of patients who have autoimmune dysautonomia - and in these cases, if the titers of the antibodies are below .2 nmol/L, usually, those don't have a high specificity for AAG diagnosis. So, I get referred a lot of patients with very low titers of a3 ganglionic receptor antibodies, where the clinical picture does not at all look like autoimmune autonomic ganglionopathy. So, that's another thing to potentially keep in mind. And then, on the seronegative front, it's important to recognize that we are still sort of seeing the tip of the iceberg as far as these antibodies or biomarkers are concerned, specifically for certain phenotypes, such as CIDP. If you look at the literature, depending upon what demographics we're looking at or sort of racial profiles we're looking at, the frequency of these autoimmune neuropathy biomarkers range from 5% to 20%, with much higher frequency in Asian patients - so, a good chunk of these diseases are still seronegative. In the scenario where you have a very high suspicion for an autoimmune neuromuscular disorder (specifically, we'll talk about neuropathies, because that's why we utilize tissue immunofluorescence staining on neural tissues), I recommend people to potentially touch base with that tertiary care lab or that referral lab to see if they have come across some research-based antibodies which are not clinically validated, which can give you some idea, some additional supportive idea, that what you're dealing with is an autoimmune neuromuscular disorder. So, we have to keep the limitations of some of these antibody panels and antibody tests in mind for both positive, as well as negative, results. Dr Monteith: So, you've already given us a lot of good stuff, um, about titer seronegativity and false-positive rates. And, you know, also looking at the clinical picture when ordering these tests, utilizing EMG nerve conduction studies, give us a major key point that we can't not get when reading your article. Dr Dubey: I think the major key point is we are neurologists first and serologists later. Most of these patients, we have to kind of evaluate them clinically and convince ourselves at least partly that this might be an autoimmune neuromuscular disorder before sending off these panels. Also, I find it useful to narrow down the phenotype, let's say, in a particular neuropathy or a muscle disease or a hyperexcitability syndrome. So, I have a core group of antigens, autoantigens, or autoantibodies, which I'm expecting and making myself aware of - things beyond that will raise my antenna - potentially, is this truly relevant? Could this be potentially false-positive? So, clinical characterization up front, phenotypic characterization upfront, and then utilizing those antibody results to support our clinical decision-making and therapeutic decision-making is what I've tried to express in this article. Dr Monteith: And what is something that you wish you knew much earlier in your career? Dr Dubey: It's a very challenging field, and it's a rapidly evolving field where we learn many things nearly every year, and, sometimes, we learn things that were previously said were incorrect, and we need to kind of work on them. A good example of that is initial reports of voltage-gated potassium-channel antibodies. So, back in the day when I was actually in my medical school and (subsequently) in my residency, voltage-gated potassium-channel antibodies were closely associated with autoimmune neuromyotonia, or autoimmune peripheral hyperexcitability syndromes. Now, over time, we've recognized that only the patients who are positive for LGI1 or CASPR2 are the ones who truly have autoimmune neuromuscular disorders or even CNS disorders. The voltage-gated potassium-channel antibody by itself, without LGI1 or CASPR2, truly doesn't have a very high specificity for neurological autoimmunity. So, that's one example of how even things which were published were considered critical thinking or critical knowledge in our field of autoimmune neuromuscular disorders has evolved and has sort of changed over time. And, again, the new antibodies are another area where nearly every year, something new pops up - not everything truly stands a test of time, but this keeps us on our toes. Dr Monteith: And what's something that a patient taught you? Dr Dubey: I think one of the things with every patient interaction I recognize is being an autoimmune neurologist, we tend to focus a lot on firstly, diagnosis, and secondly, immunotherapy - but what I've realized is symptomatic and functional care beyond immunotherapy in these patients who have autoimmune neurological disorders is as important, if not more important. That includes care of patients, involving our colleagues from physical medicine and rehab in terms of exercise regimen for these patients as we do immunotherapies, potentially getting a plan for management of associated pain, and many other factors and many other symptoms that these patients have to deal with secondary to these autoimmune neurological conditions. Dr Monteith: I think that's really well said, because we get excited about getting the diagnosis and then getting the treatment, but that long-term trajectory and quality of life is really what patients are seeking. Dr Dubey: Yeah, and as you pointed out, most of the time, especially when we are in inpatient service, or even when we're seeing the patients upfront outpatient, we are seeing them, sometimes, in their acute phase or at their disease not there. What we also have to realize is, what are the implications of these autoimmune neurological conditions in the long term or five years down the line? And that's one of the questions patients often ask me and how this can impact them even when the active immune phase has subsided - and that's something we are actively trying to learn about. Dr Monteith: So, tell me something you're really excited about in your field. Dr Dubey: I think, firstly (which is pretty much the topic of my entire article), is novel antibodies and new biomarker discoveries. That's very exciting - we are actively, ourselves, involved in the space. The second thing is better mechanistic understanding of how these antibodies cause diseases, so we can not only understand diseases, we can also try and understand how to target and treat these diseases - this is being actively done for various disorders. One of the disorders which continue to remain a challenge are T-cell mediated diseases, where these antibodies are just red flags or biomarkers are not causing the disease, but it's potentially the T-cells possibly attacking the same antigen which are causing disease process, and those are often the more refractory and harder-to-treat conditions. I'm hoping that with some of the work done in other fields (such as rheumatology or endocrinology for type one diabetes), we're able to learn and apply the same in the field of autoimmune neurology and autoimmune neuromuscular medicine. And then, the final frontier is developing therapies which are antigen specific, where you have discovered that somebody has a particular antibody, and if that antibody is pathogenic, can I just deplete that antibody, not necessarily pan-depleting the immune system. And there is some translational data, there's some animal model data in that area, which I find very exciting, will be extremely helpful for many of my patients. Dr Monteith: So, very personalized targeted therapies? Dr Dubey: Correct. Without having all the side effects we all have to kind of take care of in our patients when we start them on, let's say, cyclophosphamide, or some of these really, really, significantly suppressive immunosuppressive medications. Dr Monteith: Well, thank you so much. I learned a lot from reading your article to prepare for this interview, but also just from talking to you. And it's clear that you're very passionate about what you do and very knowledgeable as well, so, thank you so much. Dr Dubey: Thank you so much. Thank you for inviting me to do this. And thank you for inviting me to contribute the article. Dr Monteith: Today, I've been interviewing Dr Divyanshu Dubey, whose article on autoimmune neuromuscular disorders associated with neural autoantibodies appears in the most recent issue of Continuum on autoimmune neurology. Be sure to check out Continuum Audio episodes from this and other issues. And thank you to our listeners for joining us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information, important for neurology practitioners. Use this link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at Continpub.com/AudioCME. Thank you for listening to Continuum Audio.
The CDC says that sports injuries - including concussions - have increased 60% in children over the past decade. This in spite of better equipment. Many concussion related sports like basketball, soccer, and martial arts don't even require a helmet. Welcome our guest Dr. Michael Hutchison and his mission to help prevent concussions in youth athletes.✅ EXPERTISE: He helps reduce concussions through the NeuroGuard+ Mouthguard. Designed to maintain anatomical jaw alignment during contact sports. ✅ HOW Dr. Hutchinson DOES THIS: The NeuroGuard+ establishes correct “Physiologic Jaw Position.” The NeuroGuard+ fits on the LOWER TEETH and is designed to reduce and dissipate the G-Force upon impact and reduce injury. Traditional mouth guards were designed 69 years ago to cover upper teeth to prevent tooth fracture and injury to the lip and gums. As a practicing General and Neuromuscular dentist for over 32 years, I am teaching everyone to embrace the discovery of Physiologic Jaw alignment when participating in contact sports because you will reduce the risk of concussive forces reaching your brain, and you will increase your strength and performance. All mouth guards keep you from breaking your teeth. But only the NeuroGuard+ can lower the G-Force impact to your brain. ✅WHAT MAKES ME DIFFERENT: Scientific studies consistently demonstrate that maintaining physiological jaw alignment reduces risk of concussion. The NeuroGuard+ is a DIY kit to maintain your exact and strong lower jaw alignment during sports. Everyone has a unique anatomy. The NeuroGuard+ is the solution to improving safety and performance.✅HOW IT WORKS: 1️⃣ Measure your bite position to determine if additional material is needed. 2️⃣ Warm in hot water. 3️⃣ Place in mouth on LOWER teeth. 4️⃣ Form a “kiss” and swallow 5 time ✅READY TO TALK? To learn more about how to protect your loved ones on the field…Please review my profile and reach out to me on LinkedInThe Injured List Podcast:YouTube Channel Website: www.theinjuredlist.com
00:00- Working on new Newsletter 02:07- Sympathetic vs Para Sympathetic Over Training 21:51- Sample Workout 26:49- Neuromuscular vs Aerobic Runner
In this episode, Gordon Smith, MD, FAAN speaks with Casey S.W. Albin, MD, author of the article “Neuromuscular Emergencies,” in the Continuum® June 2024 Neurocritical Care issue. Dr. Smith is a Continuum® Audio interviewer and professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Albin is an assistant professor of neurology and neurosurgery in the departments of neurology and neurosurgery, division of neurocritical care at Emory University School of Medicine in Atlanta, Georgia. Additional Resources Read the article: Neuromuscular Emergencies Subscribe to Continuum: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Guest: @caseyalbin Transcript Full transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum, the premier topic-based neurology clinical review and CME journal from the American Academy of Neurology. Thank you for joining us on Continuum Audio, a companion podcast to the journal. Continuum Audio features conversations with the guest editors and authors of Continuum, who are the leading experts in their fields. Subscribers to the Continuum journal can read the full article or listen to verbatim recordings of the article by visiting the link in the show notes. Subscribers also have access to exclusive audio content not featured on the podcast. As an ad-free journal entirely supported by subscriptions, if you're not already a subscriber, we encourage you to become one. For more information on subscribing, please visit the link in the show notes. AAN members, stay tuned after the episode to hear how you can get CME for listening. Dr Smith: Hi. This is Dr Gordon Smith. I'm super excited today to be able to have the opportunity to talk to Dr Casey Albin, who will introduce herself in a second. She's well known to Continuum Nation as the Associate Editor for Media Engagement for Continuum. She's also a Neurointensivist at Emory University and wrote a really outstanding article for the neurocritical care issue of Continuum on neuromuscular emergencies. Casey, thanks for joining us. Tell us about yourself. Dr Albin: Sure. Thank you so much, Dr Smith. So, yes, I'm Casey Albin. I am a Neurointensivist. I practice at Emory. We have a really busy and diverse care that we provide at the Emory neuro ICUs. Just at the Clifton campus, there's over forty beds. So, although neuromuscular emergencies certainly do not make up the bread and butter of our practice - I mean, like many intensivists, I spend most of my time primarily caring for patients with cerebrovascular disease - this is a really interesting and just kind of a fun group of patients to take care of because of the ability we have to improve their outcomes and that some of these patients really do get better. And that's a really exciting thing to bear witness to. Dr Smith: I love finding neurointensivists that are interested in neuromuscular medicine because I share your interest in these patients and the fact that there's a lot that we can do for them. You know, how did you get interested in neurocritical care, Casey? Dr Albin: You know, I was always interested in critical care. It was really actually the neurology part that I came late to the party. I was actually, like, gearing up to apply into emergency medicine and was doing my emergency medicine sub-I (like, that was the route I was going to take), and during that sub-I, I just kept encountering patients with neurologic emergencies - so, you know, leptomeningeal carcinomatosis and obstructive hydrocephalus, and then a patient with stroke - and I realized I was just gravitating towards the neuroemergencies more so than just any general emergencies. And I had really enjoyed my neurology rotation. I did not foresee that as the path I was going to take, but after kind of spending some time and taking care of so many neurologic emergencies from the lens of an emergency department, sort of realized, like, "You know, I should go back and do a neurology sub-I.” And so, kind of, actually, late in the game is when I did that rotation and, like, dramatically changed my whole life trajectory. So, I have known since sort of that fourth year of medical school that I really wanted to focus on neurocritical care and neurologic emergencies, and I love the blend of critical care medicine and the procedural aspect of my job while doing it with the most interesting of all the organ systems. So, it's really a great blend of medicine. Dr Smith: Did you ever think about neuromuscular medicine? Dr Albin: Uh, no. Dr Smith: I had to ask. I had to ask. Dr Albin: No, I mean, I do really love neuromuscular emergencies, but I've known for forever that like, really wanted to be in an acute care setting. Dr Smith: You know, I think it's such a great story, Casey, and I know you're an educator, too, right? And, um, we hear this from learners all the time about how they come to neurology relatively late in medical school, and it's been really great to see the trajectory in terms of fellowship determination dates and giving our students opportunities to make their choice, you know, later during their medical school career. And I wonder whether your journey is an example of what we're seeing now (which is more and more students going into neurology because we're giving them the free space to do that), and then also in terms of fellowship decisions as well (which was what I was alluding to earlier)? Dr Albin: Yeah, absolutely. I think having more exposure to neurology and getting a chance to be in that clinical environment - you know, when you are doing the “brain and behaviors” (or whatever your medical school calls the neurology curriculum) - it is so hard and it's so dense, and I think that that's really overwhelming for students. And then you get into the clinical aspect of neurology, and sure, you have to know neurolocalization - and that is fundamentally important to everything we do - but the clinical application is just so beautiful and so much fun and it's so challenging, but in a good way. So, I totally agree. I think that more students need more exposure. Dr Smith: Well, I mean, that's a perfect segue to something I wanted to talk to you about, which is you brought up the beauty of neurology - which is, I think, you know, neurologic formulation, really – and we talk a lot about the elegance of the neurologic examination. But one of the things I really liked about your article was its old-school formulation – you talk about the importance of history, examination, localization, pattern recognition – I wonder if, maybe, you could give us some pearls from that approach and how you think about acute neuromuscular problems and the ICU? Dr Albin: Absolutely. I really do think that this is the cornerstone of making a good diagnosis, right? I will tell you what's really challenging about some of these patients when they are admitted to the ICU is that we are often faced with sort of a confounded exam. The patient may have been rapidly deteriorating, and they may not be able to provide a good history. They may be intubated by the time that we meet them. And so not only are they not able to provide a history themselves, but their exam may be confounded by the fact that they're on a little bit of sedation, or they were aspirating and now they have a little bit of pneumonia. I mean, it can be really challenging to get a good neurologic exam in these patients. But I do think the history and the physical are really where the money is in terms of being able to send the appropriate test. And so, when I think about these patients who get admitted to the neuro ICU, the first thing that we have to have is someone who can provide a really good collateral history, because so much of what we're trying to determine is, "Is this the first presentation, and this is a de novo (new) neuromuscular problem?” or “Had the patient actually had sort of a subacute or chronic (even) decline and they've been undiagnosed for something that was maybe a little bit more indolent, but (you know, they had an abrupt decline because, you know, they got pneumonia, or they have bloodstream infection, or whatever it was allowing them to sort of compensate) they have no longer been able to compensate?”. And so, I really do think that that's key. And when I am hearing the story the first time, that's really one of the focuses of my history – is, "Was this truly a new problem?”. And then, when we think about, you know, "Where do we localize this within the nervous system?”, it's actually quite challenging because, you know, patients with acute spinal cord pathology may also not present with the upper motor neuron findings that are classic for spinal cord pathology. And so I think, again, it's a little bit recognizing that you can be confounded and we have to keep a broad differential, but I am sort of examining for whether or not there's proximal versus distal (like, the gradient of where they're weakest), is there symmetry or asymmetry, and then, are there other, sort of, features that go along with helping us localize to something to the nerves (such as sensory symptoms or autonomic symptoms)? So when I think about, you know, where we're putting this, you can put anything in sort of the anterior horn cells or to the nerves themselves, to the neuromuscular junction, and then to the muscles. And teasing that out, I put in some figures and tables within the article to help kind of help the reader think about what are features of my patient's exam, my patient's history, that might help me to put it into one of those four categories. Dr Smith: Yeah, I was actually going to comment on the figures in your article, Casey. They're really fantastic, and I encourage all of our listeners to check it out. There's, you know, figures showing muscle group involvement and different diseases and different muscle disorders and different forms of Guillain-Barré syndrome - it's a really beautiful way of visualizing things. I wonder if we could go back, though, because I wanted to delve down a little bit in this concept of patients who have chronic neuromuscular diseases presenting into the ICU. I mean, this happens surprisingly frequently with ALS patients or, like, myotonic dystrophy. I've seen this a number of times where folks are, just, they're not diagnosed and they're kind of slowly progressing and they tipped over the edge. Can you tell us more about how you recognize this? You talked a little bit about collateral history - other words of wisdom there? Dr Albin: I would say this is one of the hardest things that we encounter in critical care medicine, because quite frequently - and I see this more with ALS than myotonic dystrophies - but, I would say, like, I don't know, once every six months, we have a patient who's undiagnosed ALS present. And I think it can be extremely difficult to tease this out because there's something that's tipped them over the edge. And as an intensivist, you were always focused on resuscitating the patient and saving them from that life-threatening thing that pushed them over the edge, and then trying to tease out, “Well, were they hypercarbic and did they have respiratory failure because, you know, they've got a little bit of COPD, and is that what's going on here?” or, "Have they been declining and has there been sort of this increase in inability to ventilate actually because of diaphragmatic weakness and because of neuromuscular weakness?” Again, the collateral history is really important. One of the things that I think we are challenged by is how difficult - and I'm sure you can comment on this, as someone who is a neuromuscular guy - is how difficult it is to get a good EMG and nerve conduction study in the ICU in patients who may have been there for a little bit, you know? I think about this, sort of, the electrical interference, the fact that the patient's body temperature has fluctuated, the fact that they are, usually, by this time, like, they're a little volume overloaded – they're puffy. You know, it can be very frustrating. I think, actually, you probably would know more about, like, what it's like to do that exam on our ICU patients. Dr Smith: Sometimes, it's really challenging, I agree. And it's the whole list of things that you raised - and I think it goes back to the first question, really. You put a premium on old-school formulation, pattern recognition, localization, and taking a good history - you know, thinking of that ALS patient, right? I mean, one of the challenges, of course, that you have to deal with in that situation is prognostication and decisions regarding intubation, right? And that's very different from (I'll give another scenario that sometimes we run into, which is the other extreme) a patient with myasthenia gravis who, maybe we expect to be able to get off a ventilator very quickly, but sometimes they're reluctant to be ventilated because of their age or advanced directives and whatnot. I wonder if you could talk a little bit about how you approach counseling patients regarding prognosis related to their underlying neuromuscular disease and the need for intubation in a period of mechanical ventilation? Dr Albin: Just like you said, it really ranges from what the underlying diagnosis is. So, one of the things that, you know, like you said, myasthenia - these patients, when they're coming in in crisis, we know that there is a good chance that they're going to respond pretty quickly to immunotherapy. I mean, I think we've all seen these patients get plasma exchange, and within a day or two, they are so much stronger (they're lifting their head off the bed, they're clearing their secretions), and every now and then, we're able to temporize those patients with just noninvasive ventilation. You know, when we're having a discussion about that with the patient and with the care team, we really have to look at the amount of secretions and how well they're clearing them, because, again, we certainly don't want them to aspirate - that really sets people back. But, you know, I think, often in those cases, we can kind of use shared decision-making of, you know, “Can we help you get through this with noninvasive?” or, you know, "Looking at you, would you be all right with a short term of intubation?” Knowing that, usually, these patients stabilize not all the time, but quite frequently, with plasma exchange, which we use preferentially. The middle of that is, then, Guillain-Barré - those patients, because of the neuropathy features (the fact that it's going to take their nerves quite some time to heal, you know) - when those patients need to be intubated, a good 70% or more are going to require longer-term ventilation. And, so, again, it's working with a family, it's working with a patient to let them know, "We suspect that you're going to need to be on the ventilator for a long time. And we suspect, actually, you would probably benefit from early tracheostomy”. And there was a really nice guidance that was just presented in the Journal of Neurocritical Care about prognosticating in patients with specifically Guillain-Barré (so that's helpful). And then, we get to the, really, very difficult (I would say the most difficult thing that we deal with in neuromuscular emergencies) - is the patient who we think might have ALS (we are not positive), and then we are faced with this diagnosis of, “Would you like to be intubated, knowing that we very likely will never extubate you?” - and that, I think, is a very difficult conversation, especially given that there is a lot of uncertainty often in the diagnosis. I would say, even more frequently, what happens is they have been intubated at an outside hospital and then transferred to us for failure to wean from the ventilator and, "Can you work it up and say whether or not this is ALS?” – and that, I think, is one of the most difficult conundrums that we face in the ICU. Dr Smith: Yeah. I mean, that's often very, very difficult. And even when the patient wants to be intubated and ultimately receive a tracheostomy, getting them out of the hospital can sometimes be a real challenge. There's so much I want to talk to you about, and, you know, you talked about prognostication - really great discussion about tools to prognosticate in GBS, both strengths of things like EGRIS and the modified EGOS, and so forth – but, I wonder (given that I'm told time is limited for us) if you could talk a little bit about bedside guidance in terms of assessing when patients need to be intubated? You provide really great definitions of different respiratory parameters and the 20/30/40 rule that I'll refer listeners to, but I wonder if you could share, what's your favorite, kind of, bedside test - or couple of bedside tests - that we can use to assess the need for ventilatory support? And this could be particularly helpful in patients who have, let's say, bifacial weakness and can't get a good seal. So, what do you recommend? Is it breath count? Is it cough? Something else? Dr Albin: I think for me, anecdotally (and I really looked for is there any evidence to support this), but for me, anecdotally - and knowing that there is not really good evidence to support this - whether or not the patient could lift their head off the bed, to me, is a very good marker of their diaphragmatic strength. You know, if they've got good neck flexion, I feel a lot better about it. The single breath count test is another thing that I kind of went down a rabbit hole of, like, "Where did this come from?” because I think, you know, it was one of the first things I was taught in residency - like, “Oh, patient with neuromuscular weakness, have them take a deep breath and count for as many breaths as they can.” We have probably all done that bedside test. It's really important to recognize that the initial literature about it was done in myasthenia patients who were in clinic (so, these were not patients who are, like, abruptly going to need intubation), and it does correlate fairly well with their forced vital capacity (meaning how much they're able to exhale on bedside perimetry), but it is not perfect. And I put that nice graph in the article, and you can see, there's a lot of patients who are able to count quite high but actually have a very low FVC, and patients who count only to ten but have a very good FVC. So, I do like the test and I continue to use it, but I, you know, put an asterisk by it. It's also really important - and I would encourage any sort of neurology trainees, or trainees in any specialty - if you're taking care of these patients, watch the respiratory therapist come and do these at the bedside with them. You'll get a much greater sense of (a) what they're doing, but (b) how well the patient tried. And it is really, I mean, we have to interpret this number in the context of, "Did they give a really good effort?” So, I'll often go to the bedside with the RT and be the one coaching the patient - saying, like, you know, “Try again”, “Practice taking this”, “Do the best you can”, “Go, go, go! Go, go, go!” (you know, like, really coaching the patient) - and you would be surprised at how much better that makes their number. And when you're really appropriately counseling them, that we actually get numbers that are much better predicting what they're doing. Then, you also have a gestalt just from being at the bedside of what they looked like during this. Dr Smith: Yeah. I used to work with a neuromuscular nurse who was truly outstanding who was the loudest and most successful vital capacity coach ever. But, you know, she'd be doing it in one room, and you'd be in the next room with a patient. They'd be like, “What are they doing next door?” She was shouting and exhorting the patient to go harder and breathe better. So, it was always, “Wow, that sounds exciting over there”. All right, this is all in a prelude. What I really want to ask you, Casey, is, you know, whenever we do Continuum Audio interviews, we, like, look up people, and it's not hard to look you up because you're everywhere on the Internet. And come to find out, you're a fully credential neuro Twitter star - and that's the term I saw, a star. So, what's it like being a Twitter star? I guess it's an X star. I don't even know what we call it anymore. Dr Albin: I guess it's that. I don't know. I don't know, either. It's so funny, um, that that has become so much of my, like, academic work. I got on Twitter, or X (whatever it is) during the pandemic because, really, my interest is in, you know, innovatives and medical education, and I really had been trained to do simulation. So, I really wanted to develop simulation curriculum. I love doing sims with our medical students to our fellows. So, I was, like, developing this whole curriculum, and then the pandemic came along, and the sim lab at Emory was like, “Mm, yeah, we're not going to let people go in the sim lab. Like, that's not exposure that we want (people in a room together)”. So one of our fellows at the time was doing a lot on Twitter and he was like, "You would love this. You have cases that you want to teach about. You should really get on board”. And I, sort of, reluctantly agreed and have found the NeuroTwitter community to be, like, just a fantastic exchange of, you know, cases, wisdom, new studies - I mean, it's the way that I keep up with what is being published in the many fields that are adjacent to neurocritical care. So, it's very funny that that has ended up being sort of something that is a really big part of my academic time. But now that we're talking about it, I will give a plug for any of the listeners who are not on X. Dr Jones and I post cases, usually twice a week, that come directly from the Continuum articles or from our files (because, you know, sometimes we can spin them a little bit), but it's an amazing, sort of case-based, way to do some, like, microteaching from all of the beautiful Continuum articles, all the cases - and because there are free articles released from the issue, you know we'll link directly to those. So, for any of the listeners who have not, kind of, joined X for all the reasons that many people cite of not joining, I would say that there's so much learning that happens - but Dr Jones and I are people to follow because of our involvement with Continuum and the great cases that we're able to showcase on that platform. Dr Smith: I think that's a great point. And, you know, there are certainly organizations that are questioning their engagement with X, and I'm on a board of an organization that's talked about not actually participating, and I brought up this point that I think the NeuroTwitter (NeuroX) community is really amazing. You'll have to give me some tips, though, I'm at, like, 498 followers or something like that. Do you know how many followers you have? I looked it up yesterday. I've got it for you if you don't know. Dr Albin: I don't know recently. Dr Smith: Yeah, 18,200 as of yesterday. That's amazing! Dr Albin: Yeah, it's worldwide. We're spreading knowledge of Continuum across the globe. It's fantastic. Dr Smith: That's crazy. Yeah, that's great work. It's really great to see the academic, kind of, productivity that comes of that. And I agree with you - Continuum has a really great presence there, and it's a great example of why you're the Associate Editor for Media Engagement. I think we're going to have to, I guess, gamify would be the right thing? Maybe we should, uh, see what the Las Vegas book is on the number of followers between you and Lyell Jones, I think. Dr Albin: Totally. Dr Smith: Yeah. Hey, Casey, this has been awesome. I've been so excited to talk to you - and I could keep talking to you for hours about your NeuroTwitter stardom – but in particular, neuromuscular weakness. I really encourage all of our listeners to check out the article. It's really, really, really, great - really enjoyed it. I learned a lot, and it reminded me a lot of things that I had forgotten. So thank you for the great article, and thanks for a really fun discussion. Dr Albin: Thank you, Dr Smith. It was truly a pleasure. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, please consider subscribing to the journal. There's a link in the episode notes. We'd also appreciate you following the podcast and rating or reviewing it. AAN members, go to the link in the episode notes and complete the evaluation to get CME for this article. Thank you for listening to Continuum Audio.
En este episodio me acompaña Gaby Furlán terapista neuromuscular para hablar de las cervicales, sus enfermedades y su código emocional. Para ponerse en contacto con Gaby: https://www.instagram.com/gaby.furlan.urrutia/ Suscríbete al boletín para recibir noticias de programas, eventos, libros, blog y mercadería.Ingresa a https://www.carolinalamujerdehoy.com.gt y se parte de esta tribu de almas conscientes.NUESTRAS REDES SOCIALES https://www.facebook.com/CarolinaLaMujerDeHoyhttps://www.instagram.com/carolinalamujerdehoy/https://twitter.com/carolinalamuje1https://www.pinterest.com/carolinalamujerdehoy/https://www.tiktok.com/@carolinalamujerdehoy?_t=8dkUaTNYCCj&_r=1https://t.me/carolinalamujerdehoySee omnystudio.com/listener for privacy information.
Hear from elite tennis coach and trainer to Serena & Venus Williams, Rick Macci, and Dr. Niva Jerath, former elite tennis player and board-certified doctor in neuromuscular medicine, on the power of our positive thoughts. Dr. Niva and Rick co-authored "Billion Dollar Mind" which dives deep into lessons learned through tennis on getting our minds right, and how we can train our brains for more positive thinking. In this episode, we discuss: Dr. Niva & Rick's shared background in tennis and lessons they've learned on grit/resilience through the sport The inspiration for co-authoring “Billion Dollar Mind” - a guide on the power of positive thoughts The neuroscience behind positive thinking & how this impacts our quality of life The importance of not letting our thoughts control us How Dr. Niva & Rick define happiness, and what brings them endorphins --- Support this podcast: https://podcasters.spotify.com/pod/show/stella-stephanopoulos/support
Today, I'm thrilled to sit down with Dr. Taylor Bullock, a final-year dermatology resident who's Instagram I LOVE. We cover the gamut from skin cancer and the genetic predisposition in melanoma, to ways of optimizing your skin during aging with lasers and radio frequency. Of course, we couldn't ignore the hot topic of botox and exploring the risks, benefits, and the science behind neuromodulators. Listen in for an informative conversation on all things skin. On This Episode We Cover: 01:39 - Dr. Bullocks background & nutritional training 05:40 - Types of skin cancer 09:44 - Types of sunscreen & sun protections 16:34 - Genetic predisposition to melanoma 20:58 - The diagnostics of skin cancer 27:01 - Exclusion zone water 31:19 - Zinc & neuromodulators 34:01 - Botox, fillers, laser and other cosmetic surgery types 39:35 - Radiofrequency microneedling 43:06 - Holistic heal and your skin 47:09 - Aging gracefully 48:29 - The risks of too much botox 53:16 - Neuromuscular feedback to the brain 57:26 - Long term risks of botox use 01:00:01 - Counterfeit botox 01:03:42 - Personal experiences with allopathic medicine Sponsored By: Momentous Go to livemomentous.com and use code DRTYNA to get 15% off all my favorite products Alitura Use Code DRTYNA for 20% off alituranaturals.com LMNT Get your free Sample Pack with any LMNT purchase at drinkLMNT.com/drtyna Divi Go to diviofficial.com/DRTYNA and use code DRTYNA for 20% off your first order. NutriSense Get $30 OFF with code DRTYNA at nutrisense.io/drtyna Check Out Dr. Taylor Bullock: Instagram Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
Wise Divine Women - Libido - Menopause - Hormones- Oh My! The Unfiltered Truth for Christian Women
Today on the Wise Divine Women Podcast I spoke with Dr. Mansi completed her Doctor of Naturopathic Medicine degree, summa cum laude, at the University of Bridgeport in Connecticut. She practices as a functional and holistic medicine practitioner, specializing in chronic disease, mental health, neuromuscular disease, and preventative medicine. Dr. Mansi whole-heartedly believes in finding the root cause of disease instead of just treating symptoms. She helps her clients discover their body's innate capacity to heal, using the wisdom of ancient practices of medicine, combined with modern-day research and technology. Dr. Mansi's treatment model is personalized to treat the whole person - the physical, mental, emotional, and spiritual realms of the body. Her treatment protocols that include: dance/movement therapy, botanical medicine, dietary supplementation, clinical nutrition, breath work, hydrotherapy, homeopathy, and lifestyle modifications. Dr. Mansi is also a certified YogaBody Breath Coach, Health Coach, Nutrition Therapist, and professional classical Indian dancer. She loves experimenting in the kitchen, motivational writing, and getting lost in nature's meditations. Website: https://www.drmansivira.com/ Instagram: https://www.instagram.com/dr.mansivira/?hl=en --- Send in a voice message: https://podcasters.spotify.com/pod/show/wisedivinewomen/message
Dr. Nadia Khalil interviews Dr. Ileana Howard and Dr. Kelly Gwathmey on their careers in neuromuscular medicine. They define a neuromuscular practice and highlight how meaningful, challenging, and exciting this field of medicine is.
Don't miss the opportunity to learn more from Dr. Mistry in person at the Interdisciplinary Perspectives Uniting Women in Dentistry event on September 6-7, 2024, in Tacoma, WA. This event will offer attendees valuable insights into compassionate patient care, advanced dental techniques, and more. https://tmdcollective.com/ipuwd/In this engaging episode of Jaw Talk with host, Dr. Tiffany Lamberton, listeners are treated to an in-depth conversation with Dr. Priya Mistry, a highly esteemed graduate of the University of the Pacific Arthur A. Dugoni School of Dentistry. Dr. Mistry, renowned for her expertise in TMJ/TMD and dental sleep medicine, shares her journey from her educational beginnings to her present status as a Diplomate of the American Board of Dental Sleep Medicine. Throughout the episode, she delves into various aspects of dental care, including patient intake practices, case studies, the significance of neuromuscular dentistry, and her role with the International College of Cranio-Mandibular Orthopedics (ICCMO). Additionally, Dr. Mistry discusses her approach to treating TMJ/TMD. The episode also touches on her use of social media as a platform for educating both patients and dental professionals. This episode comprehensively examines Dr. Mistry's contributions to dentistry and her passion for helping patients achieve optimal dental health.We talk about:[0:00] Intro[03:09] Dr. Priya Mistry's dental journey[05:08] Patient intake practice[06:53] Case study[09:40] Neuromuscular dentistry and ICCMO[12:28] Supporting TMD patients[18:00] Disc recapture[23:24] Dental school education[25:32] Shift in dentistry[27:36] What Priya is excited about[28:44] ICCMO fellowshipConnect with Dr. Priya Mistry here:https://tmjdentaldoc.com/https://www.instagram.com/the_tmj_doc/http://www.youtube.com/@theTMJdocConnect with Tiffany here:Interdisciplinary Perspectives Uniting Women in Dentistry: https://tmdcollective.com/ipuwd/Courses: https://www.tmdcollective.com/courseshttps://www.instagram.com/tmd.collective/Support the Show: https://www.buzzsprout.com/2170917/supportSupport the Show.
As part of the 2024 Developmental Disabilities Conference, Dr. Peter Kang, Professor of Genetics at the University of Minnesota, presents a detailed summary of recent advances in gene therapy for children with neuromuscular disorders, specifically Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, and Pompe Disease. He uses case studies to demonstrate diagnostic dilemmas, intricacies of developing and delivering treatment, and the importance of shared decision making about therapies with families. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 39747]
On this episode of The Association Podcast, we had the privilege of speaking with Morgan Roth, the Chief Marketing Officer of the Muscular Dystrophy Association. Morgan shares her fascinating career journey from broadcasting to the nonprofit sector, emphasizing her personal connection to MDA's mission as she lives with Charcot-Marie-Tooth disease. The discussion highlights significant milestones, such as recent FAA legislation improving air travel accessibility for people with disabilities, the organization's comprehensive roles in research, multidisciplinary care, and advocacy, and their community outreach activities. We also touch on the importance of digital fluency, actionable data, and proactive decision-making in nonprofit leadership. Morgan shares her pride in MDA's achievements and her commitment to supporting and advancing the neuromuscular disease community.
Dr. Kelly Gwathmey interviews Dr. Juerd Wijntjes on The Comparison of Muscle Ultrasound and Needle Electromyography Findings in Neuromuscular Disorders.
In this episode, we review the high-yield topic of Neuromuscular Scoliosis from the Spine section. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message
This week, Dr. Abbie Ross, PT, NCS, and Dr. Danielle Tolman, PT sit down with Allison Hirshey to discuss her tips for living with chronic dizziness. Allison's Resources: The Steady Coach (Youtube channel includes link to her free chronic dizziness course) o Dr. Yonit Arthur is a board-certified audiologist and certified strength coach who aims to help those suffering with chronic dizziness and other vestibular symptoms o The Steady Coach also has a podcast https://www.youtube.com/c/thesteadycoach Conscious Healing - Retrain Your Brain: Overcoming Neural Circuit Dizziness Course o Megan suffered with PPPD/MdDS type symptoms for years and has found her way to recovery. She now offers 1:1 coaching and a course she created around healing chronic dizziness https://conscioushealing.uk/courses/retrain-your-brain-overcoming-neural-circuit-dizziness/ The Better Mind Center o The therapy center I work with, they have a multitude of psychotherapists who are trained in working with patients who suffer from chronic pain and/or chronic dizziness. https://bettermindcenter.com Supplements that helped me: Magnesium Glycinate, Magnesium Threonate (specifically Pure Encapsulations CogniMag), Riboflavin Vitamin B2, Vitamin D3 + K2, Bach Flower Drops (natural stress/anxiety relief), essential oils (for stress/anxiety relief) VRT: Balancing Act Rehabilitation https://www.balancingactrehab.com/about Alternative Medicine that helped me: o Acupuncture o Massage - specifically Neuromuscular and Craniosacral Therapies Books: The Way Out by Alan Gordon o Takes a mind-body approach to healing chronic pain. The book uses the word “pain” but the same approach can be used for dizziness, just insert “dizziness” anytime “pain” is used. o There is an audio version as well which is great for those with symptoms that make reading difficult Victory of Vestibular Migraine by Dr. Shin Beh o Extremely informative for those suffering with vestibular migraine but offers take aways to anyone who is suffering with vestibular symptoms Hosted by Dr. Abbie Ross, PT, NCS, and Dr. Danielle Tolman, PT For Episode Recommendations or Requests, email us info@balancingactrehab.com Where to find us: https://link.me/balancingactrehab www.BalancingActRehab.com Facebook: @BalancingActRehab Instagram: @BalancingActRehab Twitter: @DizzyDoctors TikTok: @BalancingActRehab
A patient with multiple sclerosis experiences discrete attacks of symptoms followed by periods of alleviation. Which of the following disease courses is MOST likely present? Find it all out in the podcast! Be prepared for the NPTE so that you can pass with flying colors! Check out www.ptfinalexam.com/podcast for more information and to stay up-to-date with our latest courses and projects. Free NPTE Premium Course in Chicago, Feb 29-Mar 1 (Free housing and meals)
What are the keys to becoming a better and more efficient cyclist? Today, we look at the diffrent methods of training. We explore quality over quantity and also look at the "gameification" of cycling. We get into the biggest trap people fall into along with a detailed look at what it means to really improve your aerobic threshold. We talk about dialing in your zones and efforts, along with the lowest hanging fruit for most triathletes. Are you doing too much V02 max work? How do you train hard and race easy? We look at the importance of good torque and moving that ceiling. Neuromuscular connectivity along with great workouts to improve it. Big gear training and the power of grinding in a slow cadence. Avoiding knee pain. Learning how to feel out what your body is capable of today. Aerobic efficiency is the name of the game. Thanks for listening! Topics: Negotiating moods in cloudy weather The 2024 Club Plan is Now Available!! Introducing New Coaches! The keys to inside cycling Different methodology when it comes to cycling Quality over quantity? Cycing has become "gameified" Are you hammering yourself to death? The biggest cycling trap people fall into How to stay engaged in hte workout Make sure YOUR intensitity is dialed in Over-inflated FTP What to be doing this time of year Understanding Aerobic Threshold Too much V02 max work? Dialing in zones and efforts Are you riding enough? Lowest hanging frut for most triathletes Train hard - race easy Aerobic efficiency is the name of the game Efficiency of Torque Neuromuscular connectivity When slower makes you faster Big gear Z2, Z3, Z4 Hills are king Deep cycling muscular strength How to balance leg power Are you compensating on one side? Check your saddle When the knees splay out Knee pain? The Next Level of Feel A coach can't perfectly predict how you will feel Learn mistakes on your own The work matters Let the hills work for you Coaching Inquiries Mike Tarrolly - CrushingIron@gmail.com Robbie Bruce - C26Coach@gmail.com www.c26triathlon.com
Setting: Sports Clinic Gender: Female Age: 28 years Presenting Problem/Current Condition: Pain in the right elbow after increasing the frequency of her tennis games. Medical History: No significant medical issues Other Information: Recreational tennis player, recently started competing Physical Therapy Examination(s): Tenderness over the lateral epicondyle. Pain on resisted wrist extension Physical Therapy Plan of Care: None, this is the first visit 1. What is the MOST likely diagnosis for the patient's presentation? A) Golfer's elbow B) Tennis elbow C) Olecranon bursitis D) Cubital tunnel syndrome Answer: B) Tennis elbow Rationale: Tennis elbow, or lateral epicondylitis, is characterized by pain over the lateral epicondyle and is often exacerbated by resisted wrist extension. The patient's symptoms, along with her recent increase in tennis games, align with this condition. Tennis elbow is caused by repetitive stress on the tendons of the forearm, especially those that straighten the wrist. Given the physical examination findings and the patient's history, tennis elbow is the most appropriate diagnosis. 2. What is the INITIAL recommended management for this condition? A) Complete rest and avoidance of all physical activity B) Activity modification and pain management C) Immediate surgical intervention D) High-intensity resistance training Answer: B) Activity modification and pain management Rationale: For tennis elbow (lateral epicondylitis), the initial treatment approach typically involves conservative measures. Activity modification means adjusting or reducing activities that aggravate the condition, like certain tennis strokes. Pain management can include methods like ice, non-steroidal anti-inflammatory drugs (NSAIDs), and sometimes physical therapy techniques. Surgery is usually considered only after conservative treatments have been exhausted, and high-intensity resistance training would not be appropriate during the acute phase of the condition. 3. Which of the following therapeutic modalities might be beneficial in the early stages of the condition? A) Continuous Ultrasound B) Hot pack C) Cryotherapy D) Neuromuscular Electrical Stimulation Answer: C) Cryotherapy Rationale: Cryotherapy, which involves the application of cold, can help reduce inflammation and alleviate pain in the acute stages of an injury. Continuous ultrasound and hot packs which heat the tissue may aggravate this acute condition and prolong inflammation. Neuromuscular electrical stimulation (NMES), has the purpose of increasing strength and endurance in muscular tissue. Strength and endurance are not the primary impairments at this time. LINKS MENTIONED: Did you get this question wrong?! If you were stuck between two answers and selected the wrong one, then you need to visit www.NPTEPASS.com, to learn about the #1 solution to STOP getting stuck. Are you looking for a bundle of Coach K's Top MSK Cheatsheets? Look no further: www.nptecheatsheets.com --- Support this podcast: https://podcasters.spotify.com/pod/show/thepthustle/support
Today's episode offers a whole lot of important information to sink your teeth into. I'm joined by Dr. Kevin Winters, a neuromuscular dentist who specializes in bite and jaw issues. Dr. Winters founded The Hills Dental Spa in Austin, Texas. Listeners can visit thehillsdentalspa.com to receive a free consultation. After years of grinding my teeth and countless dental issues, I worked with Dr. Winters on a full mouth restoration. And I've been blown away by the results – the process corrected my bite, alleviated my neck pain, and even changed the shape of my face. Even though neuromuscular dentistry can change lives, it's not widely understood or even taught in most dental schools. In this episode, Dr. Winters explains what neuromuscular dentistry is and why it's so impactful, taking us through the entire process of my mouth restoration as I share my personal experience. We talk about how your teeth are connected to neck pain, headaches, muscle structure, posture, and more – and get into the most common causes for grinding your teeth and how to fix them. Plus, we explore treatments for TMJ and TMD, tongue and lip ties, and sleep apnea. Dr. Winters also answers some burning questions: Is there any actual wisdom in removing wisdom teeth? What do pacifiers do to babies' jaws? And is fixing your teeth really like an instant facelift? DISCLAIMER: This podcast is presented for educational and exploratory purposes only. Published content is not intended to be used for diagnosing or treating any illness. Those responsible for this show disclaim responsibility for any possible adverse effects from the use of information presented by Luke or his guests. Please consult with your healthcare provider before using any products referenced. This podcast may contain paid endorsements for products or services. THIS SHOW IS BROUGHT TO YOU BY: SYN-FIT | Go to infinitybiotechnology.com and use code LUKE10 for 10% off. AND… COZY EARTH | Get up to 35% off site wide at cozyearth.com when you use the code “LUKE”. AND… TIMELINE NUTRITION | Go to “LUKE10” for 10% of any 2, 4 or 12-month Mitopure plans at timelinenutrition.com. AND… BON CHARGE | Use the code LIFESTYLIST for 15% off at boncharge.com/lifestylist. MORE ABOUT THIS EPISODE: (00:08) Dr. Winters' Path to Dentistry (10:01) Luke's Experience Working With Dr. Winters (22:24) Getting to the Root of the Issues (34:07) The Impact of Bottles & Pacifiers (44:01) Is There Any Wisdom in Removing Wisdom Teeth? (51:41) Treating Tongue Ties (01:00:44) The Diagnostic Process (01:16:31) The Far-Reaching Effects of TMJ & TMD (01:26:21) Fixing Your Bite Overnight (01:38:01) An Instant Facelift (01:46:07) Preparing To Build a New Bite (02:00:50) The Process of a Full Mouth Restoration (02:15:07) The Future of the Dental Industry (02:24:16) Dr. Winters' Greatest Teachers Resources: Website: thehillsdentalspa.com (Listeners receive a complimentary consultation) Instagram: @thehillsdentalspa Facebook: The Hills Dental Spa Are you ready to block harmful blue light, and look great at the same time? Check out Gilded By Luke Storey. Where fashion meets function: gildedbylukestorey.com Join me on Telegram for the uncensored content big tech won't allow me to post. It's free speech and free content: www.lukestorey.com/telegram The Life Stylist is produced by Crate Media.