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In this encore episode, we highlight key roles that zinc plays in supporting various aspects of mucosal barrier integrity, while detailing the structure of the intestinal mucosal barrier. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium 3. The Mucus Layer - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein 7. Factors Affecting Zinc Levels - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters 9. Zinc's Role in the Intestinal Barrier - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology 11. Zinc Carnosine - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsor: 1. Shop O-Liv High Phenolic Extra Virgin Olive Oil and O-Liv's Olive Oil Supplement. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!"75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Recorded on November 27, 2025 Book talk begins at 20:40 After 14 years and over 300 episodes, we have made the decision to wind down the podcast over the next year and finish in September 2026, our fifteenth anniversary. We have loved making the podcast and all of the people it has brought into our lives! We want to assure you that this decision wasn't made because of any kind of health reasons - we are simply both feeling that it's time to bring the project to a close. What we don't want to see end is our wonderful community - we will continue to see you on our Ravelry boards, at fiber events throughout the year, and on our weekly Zoom call on Saturdays at noon PST! Our 2025-2026 Fall Sweater KAL has begun and will go until January 15, 2026. You must be a member of this group to enter You must make an adult size sweater. If you have a sweater that is 50% finished or less, you can finish that sweater during our KAL Need some inspiration? We have bundles! Beginner Sweaters Bundle Adventurous Beginners to Advanced Sweater Bundle Crochet Sweaters Bundle Coming Events: New Year Fiber Retreat - January 1-4 in San Juan Bautista, CA TKGA retreat - November 6-9 in San Francisco, CA NoCKRs retreat April 10-13 in San Juan Bautista, CA KNITTING Barb has finished: 1. One Row Scarf (adopted from Stephanie Pearl McFee) using a Caron Cake 2. Bankhead Hat #35 Tracie Has Finished: 1. Carnegie Vest by James Magee (from Stitching in the Stacks) using Neighborhood Fiber Co. Studio Sport in the Sheridan Circle colorway 2. Swaddle Pal (cat) by Susan B. Anderson using assorted acrylic DK yarns 3. Leni Hat #1 by Isabelle Kraemer in Malabrigo Rios in Rheinhessen Caramel colorway 4. Leni Hat #2 by Isabelle Kraemer in Malabrigo Rios in the Aquamarine colorway 5. 2 Tubey Hats by Wooly Wurmhead in Hayfield Spirit in Sundown 6. I was a Teenage Mutant by Alex Tinsley from Doomsday Knits in Lisa SouzaBlue Faced Leicester Worsted in Styx Barb has cast on: 1. One-Row Scarf #2 Stephanie Purl McPhee using a Caron Cake 2. Pivot Cowl by Purl Soho using Duren Dyeworks in Contenment DK Tracie has cast on: 1. Nice to Gnome You by Sarah Schira using assorted scrap yarn Barb is still working on: 1. Colorwork Dip pullover by Suvi Knits, using 2 colors of Berocco Light in the Mist and the Peony colorway 3. Flax Sock pullover by Tin Can Knits, using Wonderland Dyeworks Smitten in the Deep Lilac colorway Tracie continues to work on: 1. Vanilla socks with FLK heel in Dreaming of Hue 75%SW Merino/25% Nylon in Unicorn Tales 2. Brooklyn Raglan Light* by Tori You in Mod Yarn Fingering 101 in Angeline 3. Ruby's Ruby Sweater, using the Darling Darby pattern by Jean Clement in Plymouth Encore Starz 4. #991 Neck Down Pullover for Men by Diane Soucy in Berroco Remix Chunky in the Fern colorway BOOKS Barb has finished: 1. The Frozen River by Ariel Lawhon - 4.5 stars 2. The Burgess Boys by Elizabeth Strout - 4 stars Tracie has finished: 1. The Various Haunts of Men by Susan Hill - 2 stars 2. All That is Mine I Carry with Me 3. The Mother Next Door: Medicine, Deception and Munchausen by Proxy by Andrea Dunlop - 5 stars 4. Skeleton Road (Inspector Karin Pirie #3) by Van McDermid 5. We Are All the Same in the Dark by Julia Heaberlin Tracie recommendeds content creators therapyjeff, willhitchins, professor_neil, and thespeechprof who all post reels calling out misogyny and poor male treatment of women.
The weight loss medication debate has taken a fascinating turn as public figures continue to grapple with the decision to use drugs like Ozempic and Wegovy. Oprah Winfrey, one of America's most influential personalities, has found herself at the center of this conversation, and her stance reveals the complex relationship many people have with these powerful pharmaceutical tools. For years, Oprah publicly resisted using Ozempic, stating that she felt taking the medication would be taking the easy way out. However, she later revealed that she had lost forty pounds using a weight loss medication, creating a significant shift in her public messaging that sparked considerable backlash from critics who pointed out this apparent contradiction to her earlier statements about the easy way out.The emergence of GLP-1 drugs like semaglutide, marketed as Ozempic, has fundamentally changed how we think about weight management. These medications work by suppressing appetite while you are taking them and stabilizing blood sugar levels. The science behind these drugs is compelling. A landmark clinical trial from 2021 published in the New England Journal of Medicine tested once weekly semaglutide at two point four milligrams in adults with overweight or obesity. Participants lost far more weight than those on placebo, achieving the kind of weight loss previously seen only after bariatric surgery. Beyond weight reduction, research from 2023 and 2024 found that semaglutide reduced major cardiovascular events including heart attack and stroke in people with overweight or obesity and existing heart disease, effectively moving the drug out of cosmetic territory and into life saving potential for specific patients.However, the medication comes with significant downsides that listeners should understand. Gastrointestinal side effects are not rare but rather expected. Nausea, vomiting, constipation and diarrhea affect most users, with higher doses associated with increased risks of these symptoms. These side effects represent the number one reason people discontinue the medication. Additionally, once patients stop taking the drug, hunger signals return to normal, metabolism shifts back, and many people regain some or most of the weight they lost. This is why doctors emphasize the importance of long term lifestyle changes alongside medication use.Other public figures have shared their experiences with these drugs. Elon Musk revealed using Wegovy specifically for weight loss and fitness benefits, while Tracy Morgan joked openly about being on Ozempic and losing weight like crazy. Amy Schumer admitted to trying Ozempic but quit because side effects made daily life unbearable. Sharon Osbourne publicly discussed losing too much weight on Ozempic and struggling to regain it. These varied experiences highlight that individual responses to GLP-1 medications differ significantly.The broader cultural moment surrounding Ozempic reflects how normalized GLP-1 culture has become in recent years. Social media has accelerated speculation about whether various celebrities use these drugs, with some attributing every photograph showing weight loss to semaglutide use. This tendency reveals an important problem with how we discuss body changes and medical treatments in the public sphere. Weight fluctuations at any age can result from exercise, hormones, stress, camera angles, health events, fashion and styling choices, none of which require a prescription.Ozempic remains neither a miracle nor a menace but rather a powerful medical tool that can change lives for better or worse depending on how and why it is used. The medication should only be prescribed after proper screening for heart, kidney and endocrine issues. Doctors warn against taking it before major events like weddings or holidays, obtaining it through questionable online pharmacies, or using it purely for cosmetic transformation. These drugs require genuine medical supervision and serious consideration.Thank you for tuning in to this episode. Please come back next week for more in depth coverage of health and wellness topics. Thanks for listening, please subscribe, and remember, this episode was brought to you by Quiet Please podcast networks. For more content like this, please go to Quiet Please dot Ai.Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI
On this episode, Dr. Chandler Wilfong and Dr. Edward Cho of the Gastrointestinal Cancer Program at OSF Healthcare join the podcast to discuss their work in expanding access to GI cancer care. They share how their nursing navigation program supports patients throughout the care journey, efforts to streamline services for greater convenience, and their plans to scale and broaden reach across the health system.
Featuring perspectives from Dr Tanios Bekaii-Saab and Dr Kristen K Ciombor, including the following topics: Introduction: Assessment of HER2 Status (0:00) Case: An otherwise healthy woman in her early 50s with HER2-positive metastatic gallbladder cancer and multiple intrahepatic metastases — Jeremy Lorber, MD (7:33) Case: A man in his late 60s with HER2-low metastatic gallbladder cancer — Brian P Mulherin, MD (11:58) Data Review: Biliary Tract Cancers (18:19) Case: A man in his mid 50s with HER2-positive metastatic rectal cancer — Sunil Gandhi, MD (26:25) Case: A woman in her early 60s with recurrent HER2-positive rectal cancer — Ranju Gupta, MD (31:31) Data Review: Colorectal Cancer (34:16) Case: An otherwise healthy man in his mid 50s with HER2-positive metastatic gastroesophageal junction cancer and several metastatic liver lesions — Shachar Peles, MD (38:06) Case: A man in his early 60s with recurrent HER2-positive, claudin 18.2-positive metastatic esophageal cancer — Susmitha Apuri, MD (43:21) Data Review: Gastroesophageal Cancer (46:55) Case: A man in his early 60s with HER2-positive esophageal cancer and isolated brain metastases — Priya Rudolph, MD, PhD (50:07) CME information and select publications
Dr Tanios Bekaii-Saab and Dr Kristen K Ciombor summarize the treatment landscape and review key datasets in consideration of HER2-directed therapies for patients with HER2-positive gastrointestinal cancers. CME information and select publications here.
Dr Tanios Bekaii-Saab and Dr Kristen K Ciombor summarize the treatment landscape and review key datasets in consideration of HER2-directed therapies for patients with HER2-positive gastrointestinal cancers. CME information and select publications here.
Dr Tanios Bekaii-Saab and Dr Kristen K Ciombor summarize the treatment landscape and review key datasets in consideration of HER2-directed therapies for patients with HER2-positive gastrointestinal cancers. CME information and select publications here.
You don't want to solve for this Y, Junior. Not on a full stomach, anyway.We have a lovely set of internet reviews this week, including (but not limited to) Fruit Pebble flavored Sparking Water from Liquid Death, fake mustaches' ability to absorb pacific northwestern goo, being a true human being in 'Wreck It Ralph', and a banana-based health supplement. We also do a deep dive into the late Ace Frehley's concert vibes on Momento Moreview. Do the math!Want more party? Check it out at https://www.reviewpartydotcom.com/ !
In this episode, we review the high-yield topic of Alcoholic Liver Disease from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Hepatitis from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Gastrointestinal bleeding is a frequent and potentially life-threatening presentation in the ED. With CT angiography increasingly being used as a first-line diagnostic tool, are we improving detection or simply overusing imaging? Join Dr. Guillaume as she discusses this recent JAMA Network Open study examining trends in CTA utilization for GI bleeding and whether rising scan rates are truly leading to better diagnostic yield.
In this episode, we review the high-yield topic of Hepatic Encephalopathy from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Dr. Emile Daoud, Deputy Editor of JACC Clinical Electrophysiology discusses Outcomes of Left Atrial Appendage Occlusion in Patients With and Without Gastrointestinal Bleeds.
In this episode, we review the high-yield topic of Diarrhea from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Having to “Go” has long been the enemy of runners everywhere, but might it hold the key to unlocking higher performance? While any runner can attest to how critical a well placed porta potty can be to performance, few realize the powerful science backing it up. Today on The Shakeout Podcast we're joined by Dr. Chia Hua Kuo, professor in the department of health and physical education at the Education University of Hong Kong, to explore how defecation could play a powerful role in endurance sport. From fatigue delay to enhanced cognition, you'll never look at your pre-race ritual the same way again.This episode of The Shakeout Podcast is part one in a special two part series on Taming the Tummy: How runners of all ability levels can take control of the Gastrointestinal health to feel better in training and maximize performance on race day. Stay tuned for part two, where we'll connect with Registered Dietitian Jessalyn O'Donnell to learn how we can apply the science behind GI distress to training, racing, and everyday life.Subscribe to The Shakeout Podcast feed on Apple, Spotify, YouTube or wherever you find your podcasts.Huge thank you to this week's sponsor Smartwool. Join the Smartwool mailing list to receive updates and 15% off your first purchase. https://bit.ly/4hCway5 Conditions apply: Valid on regular-priced items. Can., 16+. Initial registration only. See terms for details.
In this episode, we review the high-yield topic of Proton Pump Inhibitors from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Zollinger-Ellison (ZE) Syndrome from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Crohn's Disease from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Following a fruitful European Society of Medical Oncology (ESMO) Congress 2025 for gastrointestinal malignancies, CancerNetwork® organized an X Spaces discussion hosted by 3 experts. They were Nicholas J. Hornstein, MD, an assistant professor at the Donald and Barbara Zucker School of Medicine of Hofstra University and Northwell Health; Timothy Brown, MD, an assistant professor in the Department of Internal Medicine and the associate program director of the Hematology & Oncology Fellowship at UT Southwestern Medical Center; and Udhayvir S. Grewal, MD, an assistant professor in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Each doctor focused on a specific disease type, highlighting the most important abstracts in colorectal cancer, pancreatic neuroendocrine tumors (NETs), and upper gastrointestinal cancers. The Phase 3 MATTERHORN Trial (NCT04592913) Results from MATTERHORN demonstrated that adding durvalumab (Imfinzi) to 5-fluorouracil, leucovorin (folinic acid), oxaliplatin, and docetaxel (FLOT) improved overall survival (OS) compared with FLOT plus placebo in patients with resectable gastric/gastroesophageal junction (GEJ) adenocarcinoma, regardless of pathological status.1 In the intention-to-treat population, the median OS was not reached in either arm, and the hazard ratio (HR) was 0.78 (95% CI, 0.63-0.96; P = .021). Notably, the improvement was observed regardless of PD-L1 status; in patients with PD-L1–positive disease, the HR was 0.79 (95% CI, 0.63-0.99), and in patients with PD-L1–negative disease, the HR was 0.79 (95% CI, 0.41-1.50). “This, I believe, will seal durvalumab plus FLOT as the standard of care for resectable [gastric/GEJ] cancers,” said Brown. The Observational ASPEN Study (NCT03084770) The ASPEN study showed that active surveillance was a safe approach for patients with low-grade, asymptomatic, nonfunctioning pancreatic neuroendocrine tumors (NETs) fewer than 2 centimeters in size.2 Of the 1000 patients enrolled in the trial, 20 patients died, of whom 18 underwent active surveillance and 2 underwent surgery. Nineteen of the deaths were unrelated to pancreatic NETs; 1 death in the surgery arm was related to a pancreatic NET. After surgery, 5 patients had disease relapse or progression. With a median follow-up of 42 months (IQR, 25-60), the OS analysis showed a P value of 0.530. “This really settles the debate on whether or not to surgically operate on patients with a [pancreatic NET] size of [fewer] than 2 centimeters and shows that active surveillance is a safe option for these patients with pancreatic NETs [fewer] than 2 centimeters in size and non-functional NETs,” said Grewal. Data From the Phase 2/3 FOxTROT (NCT00647530) and Phase 2 NICHE-2 (NCT03026140) Trials Neoadjuvant nivolumab (Opdivo) plus ipilimumab (Yervoy) achieved a clinically meaningful and statistically significant improvement in long-term outcomes, including responses and survival, compared with chemotherapy strategies in patients with mismatch repair deficient (dMMR) or microsatellite instability–high (MSI-H) locally advanced colon cancer.3 In NICHE-2, neoadjuvant nivolumab plus ipilimumab achieved a 3-year disease-free survival (DFS) rate of 100% compared with 80% (95% CI, 73%-85%) with all chemotherapy strategies in FOxTROT (P
Gastrointestinal complications are common—but often underrecognized—after lung transplantation. From diarrhea and nausea to malabsorption and poor appetite, these challenges can seriously impact recovery and long-term health outcomes.In this episode of the DNS Podcast, host Christina Rollins speaks with Bridget Doyle, MS, RD, LDN, CNSC, a transplant dietitian specializing in lung transplant nutrition. Bridget shares her expertise on identifying, managing, and supporting patients through complex GI issues post-transplant.Listeners will gain insights on:✅ The most frequent GI complications following lung transplant✅ How medications like immunosuppressants and antibiotics affect digestion✅ Practical nutrition strategies for diarrhea, nausea, and poor intake✅ Food safety guidance for immunocompromised patients✅ When to consider enteral or parenteral nutrition support✅ Key labs and nutrients to monitor for optimal recoveryTune in to hear evidence-based strategies for improving GI health and supporting successful long-term outcomes for transplant recipients. Visit us at dnsdpg.org to learn more.
Turns out when federal workers stay home, America keeps right on trucking. But while Washington idles without consequence, David stumbles into actual operational chaos at Rhode Island's mysterious "Preserve," where he survives a surreal evening featuring purple-coated moguls, hostage-taking hospitality staff, disappearing celebrity chefs, militant scheduling protocols, and Hobbit houses under armed guard. Think Goodfellas meets boutique hotel meets witness protection program, with a side of free-range rams.Then the conversation turns to Colorado's Taco Bell Ultra Marathon—a 31-mile gastrointestinal minefield where runners must consume nine Taco Bells worth of food while maintaining forward momentum. Mandatory chalupa supremes, crunchwrap supremes, burrito supremes, and nachos Bellgrande—all while your body screams for mercy and every exit strategy becomes a potential biohazard. Optional "challenges" include bathing everything in Diablo sauce and doing a Diablo shooter at the finish line, plus chugging two liters of Baja Blast without vomiting.
In this episode, we review the high-yield topic of Angiodysplasia from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic Alcoholic Liver Disease from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic Mallory-Weiss Tear from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
A 52-year-old patient reports persistent midthoracic back pain that worsens at night and improves with antacid use. Which of the following actions is MOST appropriate? Find it all out in the podcast! Be prepared for the NPTE so that you can pass with flying colors! Check out www.ptfinalexam.com/podcast for more information and to stay up-to-date with our latest courses and projects. #Npte #PT #ptboards #crushtheNPTE #study #studygram #spt #ptstudent #ptlife #sptprobs #physicaltherapystudent #physicaltherapy #physio #physiotherapist #ptlife #ptstudentstudy
Inflammatory bowel diseases remain challenging for medicine, subjecting many to lifelong healthcare expenses and debilitating complications DMSO is an "umbrella remedy" treating diverse ailments through reducing inflammation, improving circulation, and reviving dying cells, making it uniquely suited for treating gastrointestinal disorders Extensive data shows DMSO produces incredible results for inflammatory bowel disorders (Crohn's disease, ulcerative colitis, IBS, diverticulitis, leaky gut syndrome, SIBO) and effectively protects gastrointestinal tissues from a wide range of otherwise lethal stressors Data also supports using DMSO for severe GI tract issues (gastritis, peptic ulcers, liver cirrhosis, cholecystitis, pancreatitis, peritonitis, amyloidosis) and problems like hemorrhoids and prostate enlargement This article will review how DMSO can be used to treat those conditions
In this encore episode, we detail hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on intestinal motility. We briefly review anatomy, focusing on and detailing the interplay between structures supporting motility. Lastly, we detail possible symptoms of hydrogen sulfide-dominant SIBO as well as possible overlap between or among subtypes.Topics:1. Introduction to Hydrogen Sulfide-Dominant SIBO - Overview of hydrogen sulfide (H₂S) SIBO - H₂S production - Sulfur-containing amino acids - Physiological roles of H₂S vs. in excess 2. Hydrogen Sulfide and Gastrointestinal Motility - Possible impact on transit - Possible association with IBS-like symptoms in excess 3. Anatomy: Intestinal Motility - ENS as the "second brain" - Myenteric and submucosal plexuses: regulation of peristalsis, secretion, blood flow - Gut-brain axis involvement - ICCs as pacemaker cells - MMC's role in clearing debris and bacteria 4. Dysregulated Motility and SIBO5. Overlap Across SIBO Subtypes - Possible symptoms - Hydrogen and H₂S-dominant SIBO vs. IMO 6. Gastric Acid and Its Role - HCl secretion by parietal cells and its role in digestion and microbial defense - Hypochlorhydria 7. Conclusion - Root cause approach.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Entrevista com o Dr. Rafel Faversani.
From heartburn and IBS to more serious gastrointestinal issues like IBD and GERD, First Physicians Group gastroenterologist Mark Radetic, MD, breaks down symptoms, causes, and the latest treatment options.You can also watch the video recording on our Vimeo channel here.For more health tips & news you can use from experts you trust, sign up for Sarasota Memorial's monthly digital newsletter, Healthe-Matters.
Listen in as Dr Trevor Van Schooneveld explores rapid syndromic testing for gastrointestinal and joint infections and discusses how to apply best practices for diagnostic and antimicrobial stewardship in syndromic testing. Topics covered include: Who should be tested for infectious diarrheaTypes of gastrointestinal syndromic panelsTypes of syndromic panels for joint infectionsReal-world applications for joint syndromic panelsPresenters: Trevor Van Schooneveld, MDProfessor, Division of Infectious DiseasesMedical Director, Antimicrobial Stewardship ProgramDepartment of Internal MedicineUniversity of Nebraska Medical CenterOmaha, NebraskaLink to full program: https://bit.ly/4mHOTtWGet access to all of our new podcasts by subscribing to the CCO Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.
Get the AD-FREE version of my sessions - PLUS playlists, repeat options, offline access, and THOUSANDS more sessions for day, sleep, and deep 4-hour sleep at https://www.freehypnosis.app Unlock your body's natural ability to heal gastritis, IBS, inflammation, and food sensitivities with this powerful daytime hypnosis session.
Get the AD-FREE version of my sessions - PLUS playlists, repeat options, offline access, and THOUSANDS more sessions for day, sleep, and deep 4-hour sleep at https://www.freehypnosis.app Experience deep, natural healing with this guided meditation designed to soothe and restore your gut. Whether you're struggling with IBS, gastritis, food sensitivities, or chronic inflammation
BUFFALO, NY – August 19, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 19, 2025, titled “The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo.” In this study, led by first authors Laurence Booth and Michael R. Booth, along with corresponding author Paul Dent from Virginia Commonwealth University, researchers investigated how aramchol, a drug originally developed for liver disease, works with the cancer drug regorafenib in gastrointestinal (GI) tumor cells. They found that the combination is effective, especially in tumor cells with a specific genetic variant. The combined approach offers a potential new strategy for treating liver and colon cancers. Gastrointestinal cancers, such as liver and colon cancer, are serious global health challenges. Regorafenib, already approved for cancer treatment, can have limited impact and frequently causes side effects. Aramchol, a drug developed to treat fatty liver disease, affects how cancer cells process fats and energy. In this study, researchers tested whether combining these two drugs could improve GI cancer treatment, both in cells and mouse models. The results showed that the drug combination killed liver and colorectal cancer cells more effectively than either drug alone. In animal models, mice with human liver tumors had slower tumor growth, without showing signs of weight loss or other toxicity. The researchers also found that aramchol and regorafenib work together to block important survival pathways inside cancer cells. This combination was especially effective in cells with a genetic variant called ATG16L1 T300, which is more common in people of African ancestry. The treatment triggered stress responses in the cancer cells and disrupted key proteins required for survival. It also activated autophagy, a natural recycling process that clears out damaged parts, eventually leading to cancer cell death. “Aramchol interacted with the multi-kinase inhibitors sorafenib, regorafenib or lenvatinib, to kill GI tumor cells, with regorafenib exhibiting the greatest effect.” Aramchol is currently in clinical trials for fatty liver disease and has a well-established safety profile, while regorafenib is already FDA-approved for cancer treatment. Together, their combination could advance fast into clinical testing for patients with GI cancers. However, researchers note that additional studies are needed to support the launch of early-phase clinical trials. Altogether, this study may offer a more effective and less toxic alternative to current treatments for GI cancers. It also highlights the role of genetic variants in shaping treatment response, suggesting that future therapies could be more precisely tailored to each patient's unique genetic profile. DOI - https://doi.org/10.18632/oncotarget.28762 Correspondence to - Paul Dent - paul.dent@vcuhealth.org Video short - https://www.youtube.com/watch?v=5saAqsqxi-Q Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28762 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, macroautophagy, flux; ER stress, aramchol, regorafenib To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
In this episode, we detail the structure and function of the intestinal mucosal barrier, highlighting key roles that zinc plays in supporting various aspects of mucosal barrier integrity. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium 3. The Mucus Layer - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein 7. Factors Affecting Zinc Levels - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters 9. Zinc's Role in the Intestinal Barrier - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology 11. Zinc Carnosine - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsors: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.3. Codex Labs: Explore Codex Labs' collections for acne, eczema, and more. Shop the BIA Collection HereThanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Su study: https://www.nature.com/articles/s41564-024-01739-1Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/postsDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems(6:22) POMC; HPA; Stress example(8:19) Common Autism problems in the GI(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation(14:09) Melanin/POMC; Clock-Timing; Omentum(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut(19:04) Vitamin D Receptors and more Clock-Timing(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids(24:33) Avoiding UV Light implications(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD(38:27) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAEmail: info.fromthespectrum@gmail.com
Interview with Connor Prosty, MD, author of Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis: A Systematic Review and Bayesian Meta-Analysis, and Catherine Mezzacappa, MD, MPH, author of Antibiotic Prophylaxis in Variceal Hemorrhage—Time to Stop? Hosted by Ilana Richman, MD. Related Content: Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis Antibiotic Prophylaxis in Variceal Hemorrhage—Time to Stop?
Contributor: Megan Hurley MD Educational Pearls: Acute toxicity of heavy metals: Gastrointestinal upset is the most common presentation Chronic toxicity of heavy metals: Symptoms depend on the metal ingested Increased risk of cancer Altered mentation Developmental delays (in children) Kidney failure Four heavy metals that are tested for in a general panel and their sources: Lead Old paint (homes built before 1977) or some older toys Pipes of older homes or those with corrosive agents May obtain testing kits from home improvement stores to test water supply Mercury Previously in thermometers, although much less common now Compact fluorescent lightbulbs, LCD screens, and some batteries Large predatory fish like tuna, swordfish, dolphins, and shark Arsenic sources Most commonly found in pesticides Contaminated groundwater (especially private wells) Cadmiun sources Most commonly found in tobacco smoke Batteries Metal plating and welding Additional heavy metals that require specific testing Chromium, Nickel, & Thallium Thallium is found in rodenticides, pesticides, and fireworks Management of heavy metal toxicity depends on the intoxicant Generally, chelation therapy is used for acute and severe cases Arsenic: dimercaprol or DMSA Mercury: DMPS (chronic or mild) or DMSA (severe) Lead: succimer is first line, followed by dimercaprol or EDTA References Baker BA, Cassano VA, Murray C; ACOEM Task Force on Arsenic Exposure. Arsenic Exposure, Assessment, Toxicity, Diagnosis, and Management: Guidance for Occupational and Environmental Physicians. J Occup Environ Med. 2018;60(12):e634-e639. doi:10.1097/JOM.0000000000001485 Balali-Mood M, Naseri K, Tahergorabi Z, Khazdair MR, Sadeghi M. Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol. 2021;12:643972. Published 2021 Apr 13. doi:10.3389/fphar.2021.643972 Kinally C, Fuller R, Larsen B, Hu H, Lanphear B. A review of lead exposure source attributional studies. Sci Total Environ. 2025;990:179838. doi:10.1016/j.scitotenv.2025.179838 Jannetto PJ, Cowl CT. Elementary Overview of Heavy Metals. Clin Chem. 2023;69(4):336-349. doi:10.1093/clinchem/hvad022 Järup L. Hazards of heavy metal contamination. Br Med Bull. 2003;68:167-182. doi:10.1093/bmb/ldg032 Zhang H, Reynolds M. Cadmium exposure in living organisms: A short review. Sci Total Environ. 2019;678:761-767. doi:10.1016/j.scitotenv.2019.04.395 Summarized & Edited by Jorge Chalit, OMS4 Donate: https://emergencymedicalminute.org/donate/
In this encore episode, we highlight the role of vitamin B1 (thiamine) in supporting gastrointestinal function, focusing on intestinal motility while detailing vitamin B1's involvement in acetyl-CoA and acetylcholine synthesis. We discuss thiamine insufficiency as well as how small intestinal bacterial overgrowth (SIBO) may further affect thiamine availability. We further detail host defense mechanisms—including gastric acid, pancreatic enzymes, and gastrointestinal motility—that work in concert to regulate microbial balance in the small intestine. Topics: 1. Introduction- Focus on SIBO, intestinal motility, and vitamin B1 (thiamine) 2. Small Intestine and Microbial Regulation- Low bacterial load under healthy conditions - Protective mechanisms: gastric acid, enzymes, motility… 3. Overview of SIBO Subtypes - H₂-SIBO, hydrogen-producing bacteria - IMO, methane-producing archaea - H₂S-SIBO, hydrogen sulfide-producing bacteria - Subtypes can coexist, share underlying factors 4. Host Factors in Microbial Regulation - Gastric acid, motility, pancreatic enzymes, bile acids, and immune surveillance 5. Gastric Acid and Parietal Cells - Hydrochloric acid and intrinsic factor - Acid environment supports digestion and microbial regulation - Protein denaturation and pepsin activation 6. Chief Cells and Enzyme Function - Pepsinogen and gastric lipase - Pepsinogen activated by acidic pH 7. Hypochlorhydria and Downstream Effects 8. Pancreatic Enzymes in the Small Intestine 9. Intestinal Motility and the Enteric Nervous System (ENS)- Coordinated smooth muscle contractions - Myenteric and submucosal plexuses 10. Intestinal Wall Anatomy - Epithelium and lamina propria - Submucosa contains the submucosal plexus - Myenteric plexus located between muscle layers 11. Vitamin B1 (Thiamine) and Gastrointestinal Function - Acetylcholine synthesized from choline and acetyl-CoA - Acetyl-CoA formation, thiamine availability - Acetylcholine signaling 12. SIBO and Nutrient Availability- Bacterial overgrowth can affect nutrient absorption - Thiaminases 13. Conclusion - Root cause approach, multi-factorial Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX 2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
Durante seis días, se reunirán reconocidos talentos nacionales e internacionales en un festival que rinde homenaje a la riqueza culinaria global, fusionando sabores e ingredientes de todo el mundo con la esencia de la cocina mexicana. Hosted on Acast. See acast.com/privacy for more information.
ICYMI: Hour Three of ‘Later, with Mo'Kelly' Presents – A look at the Weekend Box Office AND a recent outbreak that spread amongst more than 140 people aboard a Royal Caribbean cruise…PLUS – Remembrances of actor, musician, poet and activist Malcolm Jamal Warner, who has tragically passed at the age of 54 - on KFI AM 640…Live everywhere on the iHeartRadio app & YouTube @MrMoKelly
Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric cancers. Coauthor Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute joins JAMA Deputy Editor Kristin Walter, MD, MS to discuss. Related Content: Early-Onset Gastrointestinal Cancers Screening for Helicobacter pylori to Prevent Gastric Cancer First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer
In this episode, we review the high-yield topic Lower GI Bleed from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic Primary Biliary Cholangitis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic Ischemic Colitis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic Acute Hepatitis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic Mesenteric Ischemia from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
Max Trescott interviews Dr. John Trowbridge, a physician and former senior Aviation Medical Examiner, to tackle a hidden yet critical safety topic: how over-the-counter (OTC) and prescription medications contribute to general aviation accidents. Studies have found that up to 40% of fatal accidents involve pilots with impairing substances in their system—ranging from allergy medications to sleep aids to alcohol. The problem? Many of these substances are legal and even commonplace, yet can significantly degrade judgment, memory, attention, and coordination. Dr. Trowbridge emphasizes that many pilots—and even their doctors—are unaware of FAA wait-time guidelines. He explains the FAA's “5x rule,” which states that a pilot must wait five times the recommended dosage interval before flying. So if a medication is taken every six hours, the pilot should wait 30 hours after the last dose. For 24-hour medications like Zyrtec, the wait time stretches to five full days. The discussion highlights the particular dangers of first-generation antihistamines like Benadryl (diphenhydramine), which are highly sedating and frequently found in sleep aids like Tylenol PM, NyQuil, and Unisom. These medications, even when taken the night before, can impair cognitive function well into the next day. Alarmingly, Benadryl is the most commonly detected OTC drug in fatal GA accidents. Dr. Trowbridge also warns about second-generation antihistamines like Zyrtec and Xyzal. While marketed as “non-drowsy,” these can still cause subtle sedation, especially in combination with alcohol or other medications. Alternatives like Allegra and Claritin are usually safer and FAA-approved—but only after personal ground-testing and AME consultation. Beyond antihistamines, they explore other drug categories. For pain relief, medications like aspirin, Tylenol, ibuprofen, and Aleve are generally safe, but anything with “PM” on the label likely contains sedating ingredients. Prescription painkillers like codeine are outright disqualifying. Dr. Trowbridge shares unconventional options too, like topical lidocaine, coconut oil, and even horse liniment—though with cautions about application and legality. Sleep aids are another minefield. Melatonin is the only one on the FAA's “go list,” and even it should be ground-tested first. Nasal decongestants such as Afrin and Sudafed can raise blood pressure and cause jitteriness, making natural remedies like saline rinses or cool vapor inhalation preferable. Cough medications also pose risks. Products with dextromethorphan (like DayQuil or Delsym) can sedate, as can multi-symptom formulas marked “PM” or “nighttime.” Gastrointestinal issues are more straightforward: most antacids like Tums and Maalox are safe, but anti-diarrheals like Imodium are not, due to sedation risks. UTIs are covered with non-sedating options like AZO and D-Mannose, but Dr. Trowbridge cautions pilots never to fly if symptomatic or on unfamiliar antibiotics. The conversation then turns to alcohol. The FAA's limit is 0.04%, but even lower levels can impair judgment, night vision, and reaction time—especially when combined with other medications or altitude-related hypoxia. Max cites an older FAA study showing that alcohol above 0.04% was found in 7% of fatal pilot crashes, with 3% involving both alcohol and drugs. Finally, Dr. Trowbridge emphasizes the importance of pilot self-awareness and due diligence. Most doctors are not trained in FAA regulations and may prescribe disqualifying medications unless reminded. He urges pilots to always research their medications, consult their AME, and even speak with pharmacists about interactions and cognitive side effects. Dr. Trowbridge's website, ClearedForTakeoff.info, offers in-depth presentations on pilot health concerns like sleep, sinus issues, inflammation, and safe alternatives to disqualifying drugs. His goal is to help pilots avoid both illness and medication risks, empowering them to stay flying—and stay safe. If you're getting value from this show, please support the show via PayPal, Venmo, Zelle or Patreon. Support the Show by buying a Lightspeed ANR Headsets Max has been using only Lightspeed headsets for nearly 25 years! I love their tradeup program that let's you trade in an older Lightspeed headset for a newer model. Start with one of the links below, and Lightspeed will pay a referral fee to support Aviation News Talk. 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Check out Max's Online Courses: G1000 VFR, G1000 IFR, and Flying WAAS & GPS Approaches. Find them all at: https://www.pilotlearning.com/ Social Media Like Aviation News Talk podcast on Facebook Follow Max on Instagram Follow Max on Twitter Listen to all Aviation News Talk podcasts on YouTube or YouTube Premium "Go Around" song used by permission of Ken Dravis; you can buy his music at kendravis.com If you purchase a product through a link on our site, we may receive compensation.