Organ system within humans and other animals pertaining to the stomach and intestines
POPULARITY
Categories
140 episodes with gastrointestinal
137 episodes with gastrointestinal
433 episodes with gastrointestinal
54 episodes with gastrointestinal
19 episodes with gastrointestinal
16 episodes with gastrointestinal
79 episodes with gastrointestinal
10 episodes with gastrointestinal
16 episodes with gastrointestinal
14 episodes with gastrointestinal
14 episodes with gastrointestinal
8 episodes with gastrointestinal
12 episodes with gastrointestinal
15 episodes with gastrointestinal
7 episodes with gastrointestinal
9 episodes with gastrointestinal
8 episodes with gastrointestinal
5 episodes with gastrointestinal
7 episodes with gastrointestinal
4 episodes with gastrointestinal
9 episodes with gastrointestinal
7 episodes with gastrointestinal
6 episodes with gastrointestinal
9 episodes with gastrointestinal
4 episodes with gastrointestinal
7 episodes with gastrointestinal
7 episodes with gastrointestinal
3 episodes with gastrointestinal
6 episodes with gastrointestinal
4 episodes with gastrointestinal
3 episodes with gastrointestinal
9 episodes with gastrointestinal
4 episodes with gastrointestinal
9 episodes with gastrointestinal
4 episodes with gastrointestinal
3 episodes with gastrointestinal
9 episodes with gastrointestinal
4 episodes with gastrointestinal
3 episodes with gastrointestinal
4 episodes with gastrointestinal
5 episodes with gastrointestinal
4 episodes with gastrointestinal
2 episodes with gastrointestinal
3 episodes with gastrointestinal
2 episodes with gastrointestinal
4 episodes with gastrointestinal
2 episodes with gastrointestinal
3 episodes with gastrointestinal
3 episodes with gastrointestinal
2 episodes with gastrointestinal
4 episodes with gastrointestinal
3 episodes with gastrointestinal
8 episodes with gastrointestinal
2 episodes with gastrointestinal
In this episode, we review the high-yield topic of Barrett Esophagus from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Metoclopramide from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Esophageal Varices from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Hydatid Disease from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Hirschsprung Disease from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Whipple Disease from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Acute Cholecystitis from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Diverticulosis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Chronic Pancreatitis from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Esophagitis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Diffuse Esophageal Spasm from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Primary Sclerosing Cholangitis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Pancreatic Enzymes from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
La Dra. Marytere Herrera Martínez, oncóloga médica del Instituto Nacional de Cancerología, en la Ciudad de México, participa en el Taller de Residentes de Oncología Médica RISE, 8.ª edición, donde aborda casos clínicos de cáncer gástrico y cáncer de colon.Fecha de grabación: 16 de enero de 2026.Material exclusivo para profesionales de la salud. Este material ha sido desarrollado únicamente con fines educativos e informativos, para uso personal, y no tiene la intención de sustituir el juicio clínico de los profesionales de la salud.El contenido, las opiniones y declaraciones presentadas son responsabilidad exclusiva de los ponentes y no reflejan necesariamente la postura institucional de ScienceLink ni de terceros mencionados. La información presentada se basa en el conocimiento y la experiencia profesional de los ponentes. La veracidad, exactitud y actualidad científica de los datos son de su exclusiva responsabilidad. Así mismo garantizan que el contenido utilizado no infringe derechos de autor de terceros y asumen toda responsabilidad por su uso.ScienceLink y los terceros mencionados no se responsabilizan por daños o consecuencias derivados del uso, interpretación o aplicación de la información, ni por errores u omisiones.Se deberán de revisar las indicaciones aprobadas en el país con estricto apego al marco regulatorio aplicable para cada uno de los tratamientos y medicamentos comentados.
El Dr. Isaac Castañeda Saldaña, oncólogo médico del Centro Oncológico Estatal ISSEMyM, en Toluca, Estado de México, participa en el Taller de Residentes de Oncología Médica RISE, 8.ª edición, donde aborda casos clínicos de cáncer gástrico y cáncer de colon.Fecha de grabación: 16 de enero de 2026.Material exclusivo para profesionales de la salud. Este material ha sido desarrollado únicamente con fines educativos e informativos, para uso personal, y no tiene la intención de sustituir el juicio clínico de los profesionales de la salud.El contenido, las opiniones y declaraciones presentadas son responsabilidad exclusiva de los ponentes y no reflejan necesariamente la postura institucional de ScienceLink ni de terceros mencionados. La información presentada se basa en el conocimiento y la experiencia profesional de los ponentes. La veracidad, exactitud y actualidad científica de los datos son de su exclusiva responsabilidad. Así mismo garantizan que el contenido utilizado no infringe derechos de autor de terceros y asumen toda responsabilidad por su uso.ScienceLink y los terceros mencionados no se responsabilizan por daños o consecuencias derivados del uso, interpretación o aplicación de la información, ni por errores u omisiones.Se deberán de revisar las indicaciones aprobadas en el país con estricto apego al marco regulatorio aplicable para cada uno de los tratamientos y medicamentos comentados.
Today, our guest is a transformative figure in bowel cancer treatment. Professor Jenny Seligmann, a Consultant Medical Oncologist and Professor of Gastrointestinal and Translational Oncology at the University of Leeds, is renowned for leading the groundbreaking FOxTROT and ARIEL trials. These studies challenged traditional practices by demonstrating the advantages of administering chemotherapy before surgery, a change now saving lives and influencing worldwide protocols. As a devoted mentor and a prominent participant in Cancer Research UK's initiatives, she joins us to explore how we can personalise cancer treatment more effectively and discuss the future prospects for gastrointestinal cancer therapies. Welcome, Professor Seligmann.For more episodes, resources and blog posts, visit www.inquisitiveonc.comPlease find us on Twitter @InquisitiveOnc!If you want us to look at a specific trial or subject, email us at inquisitiveonc@gmail.comArt courtesy of Taryn SilverMusic courtesy of AlisiaBeats: https://pixabay.com/users/alisiabeats-39461785/Disclaimer: This podcast is for educational purposes only. If you are unwell, seek medical advice.Oncology for the Inquisitive Mind is recorded with the support of education grants from our foundation partners Pfizer, Gilead Pharmaceuticals and Merck Pharmaceuticals. Our partners have access to the episode at the same time you do and have no editorial control over the content. Hosted on Acast. See acast.com/privacy for more information.
🧭 REBEL Rundown 🗝️ Key Points 💉 Hydrocortisone Saves Lives:The 2023 Cape Cod Trial (NEJM) showed a clear mortality benefit and reduced need for intubation in severe CAP patients treated with hydrocortisone.📊 Guidelines Are Catching Up:The SCCM (2024) and ERS now recommend steroids for severe CAP, while ATS/IDSA updates are still pending.🔥 Redefining “Severe”:Patients requiring high FiO₂ (>50%), noninvasive or mechanical ventilation, or PSI >130 meet criteria for steroid therapy — even outside the ICU.🍬 Main Risk = Hyperglycemia:Elevated glucose was the most consistent adverse effect, but rates of GI bleed and secondary infection were not increased.🧭 Early, Targeted Use Matters:Start hydrocortisone within 24 hours of identifying severity — especially in patients with high CRP (>150) or strong inflammatory response. Click here for Direct Download of the Podcast. 📝 Introduction Corticosteroids have long sparked debate in the treatment of bacterial pneumonia — once viewed with skepticism, now increasingly supported by high-quality evidence. In this episode, Dr. Alex Chapa joins the REBEL Core Cast team to explore how the 2023 Cape Cod Trial (NEJM) reshaped practice and guideline recommendations for severe community-acquired pneumonia (CAP). 📖 Historical Context & Long-Standing Skepticism For decades, the use of steroids in pneumonia was controversial.Early Use: Steroids entered practice in the 1940s and 50s for autoimmune inflammation, but there was immediate hesitation regarding secondary superinfections.Mixed Data: From the 1980s to the 2000s, small studies emerged on severe pneumonia and ARDS, but the data was inconsistent. Different trials used varying definitions of “severe” pneumonia and different C-reactive protein (CRP) cutoffs, making the data “spread” and easy to “cherry pick” to support or deny a benefit.Past Guidelines: This uncertainty was reflected in official guidelines:2007 (ATS/IDSA): The American Thoracic Society and the Infectious Diseases Society of America did not address the topic due to insufficient data.2019 (ATS/IDSA): Pre-COVID, the guidelines recommended against using corticosteroids in severe CAP. They acknowledged no benefit for non-severe pneumonia, but the data for severe pneumonia was considered too weak to endorse.Pre-Trial Consensus: Prior to 2023, the consensus was to avoid steroids in non-severe pneumonia, while severe pneumonia remained a “gray area” with no treatment showing a clear mortality difference. 📜 The Landmark Cape Cod Trial (NEJM 2023) The Cape Cod trial, published in the New England Journal of Medicine in 2023, reignited the discussion by providing robust, positive data.Trial Design: Phase 3, multi-center, double-blind, randomized, controlled trial.Intervention: 800 patients randomized to two groups, Hydrocortisone as a continuous infusion (200mg/day) versus a placebo infusion.Taper: On day 4, clinicians would decide whether to continue the infusion or begin a taper based on clinical response.Population: Patients with severe CAP, defined by meeting at least one of the following criteria:Pneumonia Severity Index (PSI) > 130.O2 by FiO2 ratio < 300.Need for mechanical or non-invasive ventilation (with PEEP ≥ 5).Need for high FiO2 (>50%) via non-rebreather or heated high flow.Primary Outcomes: Death for any cause 6.2% (hydrocortisone) vs 11.9% (placebo)Secondary outcomes:Death from any cause at 90 days 9.3% (hydrocortisone) vs 14.7% (placebo)Endotracheal intubation 18% (hydrocortisone) vs 29% (placebo)Hospital-acquired infections 9.8% (hydrocortisone) vs 11.1% (placebo)Gastrointestinal bleeding 2.3% (hydrocortisone) vs 3.3% (placebo)Vasopressor initiation by day 28 15.3% (hydrocortisone) vs 25.0% (placebo)Key Findings: The trial demonstrated superiority for hydrocortisone 📋 Updated Guidelines & Current Practice The Cape Cod trial, along with subsequent meta-analyses, has begun to change official recommendations.Society of Critical Care Medicine (SCCM): In 2024, an SCCM expert panel, reviewing the Cape Cod trial and 18 others, strongly recommended corticosteroids for severe CAP. They concluded that steroids reduce mortality and the need for mechanical ventilation.Meta-Analysis (Smit et al.): A 2024 meta-analysis in Lancet Respiratory confirmed the 30-day mortality benefit.European Respiratory Society (ERS): The ERS has issued a recommendation to use steroids for severe pneumonia but still urges caution regarding side effects.ATS/IDSA: As of the podcast recording, the ATS/IDSA had not yet updated their 2019 guidelines. 🛠️ Practical Application for Clinicians Defining “Severe” CAP: The key is to identify patients who qualify as “severe”. This can be done using:Scoring Tools: The PSI is the best validated tool for mortality but is cumbersome. Simpler tools like CURB-65 or SMART-COP are practical and acceptable for defining severity. 2023 meta-analysis from by Zaki et al showed both work well, but CURB-65 has better mortality prediction early on.Cape Cod Criteria: Any patient meeting the trial’s inclusion criteria (e.g., high-flow O2, non-invasive ventilation) qualifies, regardless of location (ED, floor, or ICU).Biomarkers: While not required, a CRP level was used in many studies. A CRP > 150 (Cape Cod) or > 204 (Smit meta-analysis) strongly indicates severe inflammation that would benefit from steroids.Clinical Judgment: A patient who looks “sick,” has “soft” blood pressure, or has dense infiltrates and high oxygen needs (e.g., >50% FiO2 on high flow) is a candidate.Adverse Effects:Hyperglycemia: This was the most significant risk identified, with rates between 6-12%. This is a primary concern, especially in patient populations with high BMI.GI Bleed & Secondary Infection: Fears of these side effects, which contributed to historical skepticism, were not borne out in the Cape Cod trial. The data does not support being overly concerned.Other Side Effects: Mood changes, delirium, insomnia, and agitation in the elderly are known side effects of steroids that were not specifically addressed in the trial but remain clinical concerns. 🔄 Clinical Pathway for Steroids in Severe CAP Unanswered Questions & Future Research Possible remaining questions:Biomarkers: Can we find a more precise CRP level to distinguish moderate from severe disease? Could other markers like ferritin or IL-6 be used? Dosing & Tapering: How much immunomodulation is needed, and when is it truly safe to taper?Gender Differences: Early data suggests females may respond better to steroids and experience fewer side effects. The question of female patients with severe CAP require less corticosteroids needs further exploration. 👉 Clinical Bottom Line The current literature, spearheaded by the Cape Cod trial, now supports the use of corticosteroids in severe community-acquired pneumonia. The best evidence currently points to hydrocortisone, started early (within 24 hours) after severity is identified using a validated tool. While hyperglycemia is a risk, the previous fears of GI bleeding and secondary infections were not substantiated in recent, rigorous trials. 📚 References Chapa-Rodriguez A, Abou-Elmagd T, O’Rear C, Narechania S. Do patients with severe community-acquired bacterial pneumonia benefit from systemic corticosteroids?. Cleve Clin J Med. 2025;92(10):600-604. PMID: 41033846Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;388(21):1931-1941. PMID: 36942789Chaudhuri D, Nei AM, Rochwerg B, et al. 2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit Care Med. 2024;52(5):e219-e233. PMID: 38240492 Post Peer Reviewed By: Marco Propersi, DO (Twitter/X: @Marco_propersi), and Mark Ramzy, DO (X: @MRamzyDO) 👤 Show Notes Alex Chapa, MD PGY 5 Pulmonary Critical Care Fellow Cape Fear Valley Medical Center Fayetteville NC 🔎 Your Deep-Dive Starts Here REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia Corticosteroids have long sparked debate in the treatment of bacterial ... Thoracic and Respiratory Read More The post REBEL Core Cast 149: Review of Corticosteroids in Community-Acquired Pneumonia appeared first on REBEL EM - Emergency Medicine Blog.
In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.Topics:1. Introduction - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃ 2. Vitamin D Synthesis and Metabolism - Skin and 7-dehydrocholesterol; dietary intake.- Transported through the bloodstream bound to vitamin D binding protein.- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).- Testing.- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).- Local activation also occurs. 3. Intestinal Barrier Anatomy - The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.- Covered by a mucus layer.- Tight junction proteins and paracellular permeability.- The lamina propria and Gut-Associated Lymphoid Tissue (GALT). - Maintaining tolerance. 4. Vitamin D - 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more. 5. Vitamin D₂ and D₃ 6. Conclusion - Neither too high nor too low: optimal levels.- Multifactorial: Numerous factors regulate vitamin D levels.- Gastrointestinal health root cause approach.Thank you to our episode sponsor: 1. "Longevity" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code CHLOE for 25% off.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Dr. Sudipto Das completed a Bachelor's in Technology (B.Tech) - Biotechnology (honours) from Rai Foundation Colleges, Yashwantrao Chavan Maharashtra Open University, Mumbai, India in 2007, followed by a M.Res – Biomedical Sciences, University of Glasgow, U.K in 2008. Subsequently, Dr. Das obtained his PhD in cancer genetics under the supervision of Prof. Raymond Stallings in 2012. He has also spent time as a visiting research fellow in VIB, K.U., Leuven, VuMC, Amsterdam and Hoshi University, Tokyo Japan. His doctoral work gave him the opportunity to develop a core expertise in the area of epigenetics focused on DNA methylation alterations and non-coding RNAs, which he further enhanced during his Post-doctoral career. This has allowed Dr. Das to obtain prestigious fellowship from organizations such as the Irish Cancer Society, obtain several awards, develop various national and international collaborations and publish highly cited peer review articles in high-impact scientific journals (including Cancer Research, Oncogene, JCI, Nat Comms, JCO, Cancer Discovery). Dr. Das's key research focus involves application of genomics and epigenomics approaches across a several diseases especially cancer and inflammatory bowel diseases as well as heart failure, with the aim to identifying potential predictive/prognostic biomarkers and/or therapeutic targets that can ultimately aid in enhancing better patient care. His expertise has in turn allowed him to develop various international and national collaboration leading to successful funding applications from British Heart Foundation and Heart Research U.K and Japan Society for Promotion of Science. To date, Dr. Das has accrued >3.5 million euro in funding from national and international funding agencies inlcuding Research Ireland, Health Research Board, Enterprise Ireland and European Crohn's and Colitis foundation, allowing him to establish the "Epigenetics in Gastrointestinal research group". The research group primarily focusses on identifying the role of epigenetic modification as novel biomarkers and therapeutic targets in GI diseases. Dr. Das has led development and expansion of an award winning M.Sc - Technologies & Analytics in Precision medicine established in 2021 funded by the Higher Education Authority - Human Captial Iniative grant. The graduates of this programme continue to gain emplyment in leading companies such as EY, Pfizer, Grifols as well as secure prestigious PhD positions. As Vice Dean for AI and digital, connected health at RCSI, Dr. Das aims to lead the University to effectively embed AI and digital health-associated applications and concepts in research, education as well as operations/service efficiency.
In this episode of "PICU Doc On Call," Drs. Pradip Kamat and Rahul Damania discuss the acute management of a 14-year-old boy with severe rectal bleeding and hypertension, ultimately diagnosed with inflammatory bowel disease (IBD). They review the approach to pediatric lower GI bleeding, diagnostic workup, and imaging, emphasizing early recognition and resuscitation. They outline IBD management, including steroids, biologics such as infliximab, and nutritional support, while highlighting the importance of screening for infections before immunosuppression. The episode provides practical insights for PICU physicians on handling acute GI emergencies in children.Show Nighlights: Clinical case of a 14-year-old male with hypertension and rectal bleeding.Diagnosis of inflammatory bowel disease (IBD) following significant blood loss.Approach to pediatric rectal bleeding and its implications.Diagnostic workup including laboratory tests and imaging modalities.Management strategies for IBD in acute pediatric care.Importance of early recognition and resuscitation in cases of shock.Physiological principles related to blood loss and shock in children.Differential diagnoses for lower gastrointestinal bleeding in pediatrics.Initial evaluation and stabilization protocols for pediatric patients.Nutritional support and multidisciplinary care in managing IBD. References:Romano C, Oliva S, Martellossi S, et al. Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology. World J Gastroenterol. 2017;23(8):1326-1337.Pai AK, Fox VL. Gastrointestinal bleeding and management. Pediatr Clin North Am. 2017;64(3):543-561.Padilla BE, Moses W. Lower gastrointestinal bleeding and intussusception. Surg Clin North Am. 2017;97(1):63-80.Kaur M, Dalal RL, Shaffer S, Schwartz DA, Rubin DT. Inpatient management of inflammatory bowel disease-related complications. Clin Gastroenterol Hepatol. 2020;18(11):2417-2428.Ashton JJ, Ennis S, Beattie RM. Early-onset paediatric inflammatory bowel disease. Lancet Child Adolesc Health. 2017;1(2):147-158.Bouhuys M, Lexmond WS, van Rheenen PF. Pediatric inflammatory bowel disease. Pediatrics. 2022;150(6):e2022059341.Rosen MJ, Dhawan A, Saeed SA. Inflammatory bowel disease in children and adolescents. JAMA Pediatr. 2015;169(11):1053-1060.Conrad MA, Rosh JR. Pediatric Inflammatory Bowel Disease. Pediatr Clin North Am. 2017 Jun;64(3):577-591.
Welcome to Ozempic Weightloss Unlocked, the podcast where we explore the latest developments in weight loss medications and what they mean for your health. I'm your host, and today we're diving into some crucial updates about these transformative drugs.Let's start with what's happening right now. According to Pew Research, obesity affects around four in ten American adults ages twenty and older, and weight loss medications are becoming increasingly accessible. The Trump administration recently struck a deal with pharmaceutical companies to lower prices for drugs like Ozempic and Wegovy, which could mean broader availability across the country.But here's what you need to know about how these medications actually work. According to Michigan State University obesity researcher Gina Leinninger, Ozempic and similar drugs are glucagon-like peptide one receptor agonists. They work by modulating your appetite and acting in both your gastric system and brain to suppress hunger. A weekly dose of semaglutide, the key ingredient, not only suppresses appetite but also delays how quickly food leaves your stomach, helping you feel full longer.The results are significant. Clinical trials show participants lost around fifteen to twenty-two percent of their body weight over approximately one year. However, Science Focus reports that weight loss typically plateaus around sixty-five weeks, and only twelve percent of users achieve a normal body mass index after four years of use.Now, let's address the side effects you're hearing about. Gastrointestinal issues are the most common, including nausea, vomiting, and constipation. According to Dr. Vanita Rahman from the Barnard Medical Center, it feels like having a stomach bug where food just sits there uncomfortably.More concerning are mental health reports. Some users have reported anxiety, depression, and suicidal thoughts. Research from Swansea University, published in December twenty twenty-five, found a relationship between semaglutide use and reports of suicidal ideation, though they noted this wasn't definitively causal and could relate to other factors like existing mental health conditions or high doses.Eye problems are also being investigated. The same Swansea University study found a strong association between semaglutide use and a rare optic nerve disorder called non-arteritic anterior ischemic optic neuropathy, which can cause sudden vision loss. This appears to happen when blood glucose drops quickly, reducing blood flow to the eye's optic nerve.Here's a critical reality: these are what experts call forever drugs. Leinninger emphasizes that once you stop taking them, weight loss effects reverse within a month. Research shows nearly sixty-five percent of users stop taking semaglutide within a year, often due to side effects or cost. When people quit, more than sixty-five percent regain the weight within one year.The cost remains a significant barrier. These drugs can cost up to one thousand dollars monthly, though recent negotiations are helping. Only thirteen states currently cover these medications under Medicaid for obesity treatment.Experts like Dr. Rahman and Leinninger stress that these medications work best when combined with healthy eating habits and exercise. The drugs can help retrain your brain chemistry, but they're not a standalone solution. They should address the underlying reasons people consume excess calories, from stress eating to distracted overeating.One final important note: many people are obtaining these drugs from unregulated websites, which carries serious risks. The products may be fake, expired, or contain unsafe ingredients. If you're considering these medications, work with a healthcare provider who can prescribe the right drug at the right dose with proper follow-up and support.Thank you for tuning in to Ozempic Weightloss Unlocked. Please subscribe for more updates on weight loss medications and their impact on your health. This has been a Quiet Please production. For more, check out Quiet Please dot A I. Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI
Heart disease, dementia, depression, diabetes: what do these conditions have in common? Dr Will Bulsiewicz, a gastroenterologist and New York Times bestselling author, says the answer is inflammation. In today's episode, Will explains the four nutrition workhorses that can reduce inflammation, heal your gut and supercharge your immune system - in as little as 24 hours. We explore discoveries in Will's new book, Plant Powered Plus, that explain the central role inflammation plays in health. You'll learn which symptoms that seem unrelated, such as fatigue, skin breakouts, bloating, headaches, and joint pain, all share a common driver. You'll also hear why he believes the gut and the immune system rise and fall together, and how a weakened gut barrier may keep the immune system on constant alert. By the end of the episode, you will have a clear understanding of what inflammation is, how it can cause damage, and practical, food-first ideas to wrestle yourself from its clutches. What's one small change you could try this week? In your meals or your routine to help your body switch off “fight mode”? Unwrap the truth about your food
Dr. Centor discusses the comparative risk for severe gastrointestinal adverse events associated with dulaglutide, semaglutide, and tirzepatide with Dr. Wajd Alkabbani.
Matt quizzes Chris and Amy with sound-bytes from their show. Will they remember when the comments were made, and why?
In this episode, we review the high-yield topic of Choledocholithiasis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Paralytic / Adynamic Ileus from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Zollinger-Ellison Syndrome from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Splenic Laceration / Rupture from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Gastritis from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Pancreatic Pseudocyst from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Esophageal/Gastric Varices from the Gastrointestinal section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
Nutritionist Leyla Muedin details key aspects of supplement use and addresses frequently asked questions. Topics include the importance of targeted supplementation, the rationale behind personalized dosages, best practices for starting new supplements, and managing common issues like nausea and bright yellow urine. Leyla also explains why some supplements may cause gastrointestinal discomfort and provides guidance on how to adjust dosages for optimal results. Emphasis is placed on the benefits of pharmaceutical-grade supplements available on Fullscript and the necessity of regular blood tests to fine-tune supplementation.
Intestinal ischemia refers to a group of conditions seen with inadequate blood flow to the intestines. This includes acute mesenteric ischemia and chronic mesenteric ischemia, affecting the small intestine, and ischemic colitis affecting the large intestine. We cover the anatomy, pathology and signs of symptoms of each form of intestinal ischemia, and also look at the diagnosis and treatment. PDFs available here: https://rhesusmedicine.com/pages/gastroenterologyConsider subscribing (if you found any of the info useful!): https://www.youtube.com/channel/UCRks8wB6vgz0E7buP0L_5RQ?sub_confirmation=1Buy Us A Coffee!: https://www.buymeacoffee.com/rhesusmedicineTimestamps:0:00 What is Intestinal Ischemia (Ischemic Bowel Disease)0:18 Blood Supply of Intestines 1:36 Ischemic Bowel Disease Pathology2:36 Ischemic Bowel Disease Symptoms (Mesenteric Ischemia Symptoms / Ischemic Colitis Symptoms) 3:45 Intestinal Ischemia Risk Factors (Ischemic Bowel Disease Risk Factors)4:03 Ischemic Bowel Disease Diagnosis4:53 Ischemic Bowel Disease Treatment (Mesenteric Ischemia Treatment / Ischemic Colitis Treatment)LINK TO SOCIAL MEDIA: https://www.instagram.com/rhesusmedicine/ReferencesInnerBody, 2025. Blood supply of the intestines – Lower torso cardiovascular anatomy. [online] Available at: https://www.innerbody.com/anatomy/cardiovascular/lower-torso/blood-supply-intestines.National Center for Biotechnology Information (NCBI), 2020. Anatomy, Abdomen and Pelvis, Blood Supply of Small Intestine. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK554527/.MSD Manuals Professional, 2025. Acute mesenteric ischemia – Gastrointestinal disorders / Acute abdomen and surgical gastroenterology. [online] Available at: https://www.msdmanuals.com/professional/gastrointestinal-disorders/acute-abdomen-and-surgical-gastroenterology/acute-mesenteric-ischemia.Disclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.
An adult male patient reports chronic back pain that has been episodic in nature and has worsened in the last two weeks. The patient reports that the pain is exacerbated by food and radiates to the right shoulder. The patient also reports dark tarry stools. Which of the following conditions is MOST likely present? Find it all out in the podcast! Be prepared for the NPTE so that you can pass with flying colors! Check out www.ptfinalexam.com/podcast for more information and to stay up-to-date with our latest courses and projects. #Npte #PT #ptboards #crushtheNPTE #study #studygram #spt #ptstudent #ptlife #sptprobs #physicaltherapystudent #physicaltherapy #physio #physiotherapist #ptlife #ptstudentstudy
Expert insights on athlete nutrition timing: GI issues, RED-S, PCOS, and fueling strategies. Learn about tailored snack recommendations. Q: What recommendations do you have for athletes experiencing amenorrhea or relative energy deficiency in sport (RED-S)? A (Dr. Curtis): While not a typical GI condition, amenorrhea and RED-S require a multidisciplinary approach. Often, medication is prescribed to induce a period, but this does not resolve underlying hormone imbalances or decreased bone density. These conditions frequently arise from an athlete's energy deficiency, such as a marathon runner not increasing fuel intake to match activity, leading the body to prioritize survival over non-essential functions like menstruation. Q: How can athletes add more fuel to help resolve amenorrhea? A (Poole): It's a myth that athletes should not get their period; it is not normal. Addressing overall energy intake is crucial. In severe cases, decreasing activity while increasing fuel might be necessary. We often work with athletes who are injured or returning to sport, which provides an opportune time to address their fueling needs. Q: How do you address athletes dealing with PCOS and stress fractures? A (Dr. Curtis): The culture of sports often pressures athletes toward specific body images or weight classes, which is unhealthy. We must educate athletes that a balanced diet is acceptable and that restrictive diets are not always necessary. Coaches also play a role in fostering a healthier environment. Q: How do you approach discussing sensitive topics like nutrition and body image with athletes? A (Dr. Curtis): As a former pediatric sports medicine doctor, I learned the importance of creating a trusting and safe environment. While it's harder to have parents leave the room now in full sports medicine, fostering trust is key. A (Poole): We focus on the athlete's performance goals, as health often isn't the primary motivator for adolescents. We seek out what truly motivates them to achieve their best performance through proper nutrition. Q: What are the best snack recommendations for athletes? A (Bri Poole): Snack recommendations are highly individualized based on what works and what an athlete enjoys. Simple, easily digestible options like GoGo Squeez are generally safe choices. Q: Are there specific snacks you recommend for gastrointestinal (GI) comfort during exercise? A (Dr. Curtis): I don't have specific go-to snacks; the focus is on what an individual athlete likes and what doesn't cause GI distress. Suggesting foods they are unwilling to eat can lead to non-compliance. A (Poole): Simple carbohydrates are typically easy on the GI system around exercise. It's best to stick with foods the athlete has consumed before. Liquid carbohydrates can be a good option as they may sit better for some. While many believe "sugar is bad," simple sugars are the body's preferred fuel source during exercise. Q: Should athletes track their food intake? A (Poole): Some athletes have higher or different energy needs, even if they aren't playing intensely. Athletes generally have elevated caloric demands. It's perfectly fine for them to eat snacks, especially when readily available, such as on the sidelines. Q: How do you approach nutrition planning for athletes from diverse cultural backgrounds or those who observe religious practices like Ramadan? A (Poole): Always approach with an open and curious mindset. Ask questions to understand cultural practices better, especially regarding fuel timing within non-fasting windows. Work closely with the athlete to create a tailored plan. A (Dr. Curtis): Meet athletes where they are; you cannot simply forbid them from fasting. I am willing to write letters to coaches if training times need to be adjusted to accommodate an athlete's practices, ensuring they can continue to play safely. Q: How does pre-exercise nutrition differ for a morning lift versus a morning run? A (Poole): Many runners prefer not to eat before a run. For shorter runs (e.g., 5 miles or 3k), it can be acceptable if the athlete had sufficient fuel the day prior and will refuel adequately post-run. However, for exercise lasting 50-90 minutes or longer, pre-exercise fuel is essential, particularly for running due to its impact on bone resorption. The specific goals of the runner (e.g., marathon training) also influence recommendations.
This week's episode will be focusing on gastrointestinal stromal tumors, known as GIST with a 2025 update. We will go over important details on the diagnosis, mutations, and treatment of local and metastatic GISTs.
In this encore episode, we highlight key roles that zinc plays in supporting various aspects of mucosal barrier integrity, while detailing the structure of the intestinal mucosal barrier. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium 3. The Mucus Layer - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein 7. Factors Affecting Zinc Levels - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters 9. Zinc's Role in the Intestinal Barrier - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology 11. Zinc Carnosine - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsor: 1. Shop O-Liv High Phenolic Extra Virgin Olive Oil and O-Liv's Olive Oil Supplement. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Thanks for tuning in!"75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Recorded on November 27, 2025 Book talk begins at 20:40 After 14 years and over 300 episodes, we have made the decision to wind down the podcast over the next year and finish in September 2026, our fifteenth anniversary. We have loved making the podcast and all of the people it has brought into our lives! We want to assure you that this decision wasn't made because of any kind of health reasons - we are simply both feeling that it's time to bring the project to a close. What we don't want to see end is our wonderful community - we will continue to see you on our Ravelry boards, at fiber events throughout the year, and on our weekly Zoom call on Saturdays at noon PST! Our 2025-2026 Fall Sweater KAL has begun and will go until January 15, 2026. You must be a member of this group to enter You must make an adult size sweater. If you have a sweater that is 50% finished or less, you can finish that sweater during our KAL Need some inspiration? We have bundles! Beginner Sweaters Bundle Adventurous Beginners to Advanced Sweater Bundle Crochet Sweaters Bundle Coming Events: New Year Fiber Retreat - January 1-4 in San Juan Bautista, CA TKGA retreat - November 6-9 in San Francisco, CA NoCKRs retreat April 10-13 in San Juan Bautista, CA KNITTING Barb has finished: 1. One Row Scarf (adopted from Stephanie Pearl McFee) using a Caron Cake 2. Bankhead Hat #35 Tracie Has Finished: 1. Carnegie Vest by James Magee (from Stitching in the Stacks) using Neighborhood Fiber Co. Studio Sport in the Sheridan Circle colorway 2. Swaddle Pal (cat) by Susan B. Anderson using assorted acrylic DK yarns 3. Leni Hat #1 by Isabelle Kraemer in Malabrigo Rios in Rheinhessen Caramel colorway 4. Leni Hat #2 by Isabelle Kraemer in Malabrigo Rios in the Aquamarine colorway 5. 2 Tubey Hats by Wooly Wurmhead in Hayfield Spirit in Sundown 6. I was a Teenage Mutant by Alex Tinsley from Doomsday Knits in Lisa SouzaBlue Faced Leicester Worsted in Styx Barb has cast on: 1. One-Row Scarf #2 Stephanie Purl McPhee using a Caron Cake 2. Pivot Cowl by Purl Soho using Duren Dyeworks in Contenment DK Tracie has cast on: 1. Nice to Gnome You by Sarah Schira using assorted scrap yarn Barb is still working on: 1. Colorwork Dip pullover by Suvi Knits, using 2 colors of Berocco Light in the Mist and the Peony colorway 3. Flax Sock pullover by Tin Can Knits, using Wonderland Dyeworks Smitten in the Deep Lilac colorway Tracie continues to work on: 1. Vanilla socks with FLK heel in Dreaming of Hue 75%SW Merino/25% Nylon in Unicorn Tales 2. Brooklyn Raglan Light* by Tori You in Mod Yarn Fingering 101 in Angeline 3. Ruby's Ruby Sweater, using the Darling Darby pattern by Jean Clement in Plymouth Encore Starz 4. #991 Neck Down Pullover for Men by Diane Soucy in Berroco Remix Chunky in the Fern colorway BOOKS Barb has finished: 1. The Frozen River by Ariel Lawhon - 4.5 stars 2. The Burgess Boys by Elizabeth Strout - 4 stars Tracie has finished: 1. The Various Haunts of Men by Susan Hill - 2 stars 2. All That is Mine I Carry with Me 3. The Mother Next Door: Medicine, Deception and Munchausen by Proxy by Andrea Dunlop - 5 stars 4. Skeleton Road (Inspector Karin Pirie #3) by Van McDermid 5. We Are All the Same in the Dark by Julia Heaberlin Tracie recommendeds content creators therapyjeff, willhitchins, professor_neil, and thespeechprof who all post reels calling out misogyny and poor male treatment of women.
On this episode, Dr. Chandler Wilfong and Dr. Edward Cho of the Gastrointestinal Cancer Program at OSF Healthcare join the podcast to discuss their work in expanding access to GI cancer care. They share how their nursing navigation program supports patients throughout the care journey, efforts to streamline services for greater convenience, and their plans to scale and broaden reach across the health system.
Featuring perspectives from Dr Tanios Bekaii-Saab and Dr Kristen K Ciombor, including the following topics: Introduction: Assessment of HER2 Status (0:00) Case: An otherwise healthy woman in her early 50s with HER2-positive metastatic gallbladder cancer and multiple intrahepatic metastases — Jeremy Lorber, MD (7:33) Case: A man in his late 60s with HER2-low metastatic gallbladder cancer — Brian P Mulherin, MD (11:58) Data Review: Biliary Tract Cancers (18:19) Case: A man in his mid 50s with HER2-positive metastatic rectal cancer — Sunil Gandhi, MD (26:25) Case: A woman in her early 60s with recurrent HER2-positive rectal cancer — Ranju Gupta, MD (31:31) Data Review: Colorectal Cancer (34:16) Case: An otherwise healthy man in his mid 50s with HER2-positive metastatic gastroesophageal junction cancer and several metastatic liver lesions — Shachar Peles, MD (38:06) Case: A man in his early 60s with recurrent HER2-positive, claudin 18.2-positive metastatic esophageal cancer — Susmitha Apuri, MD (43:21) Data Review: Gastroesophageal Cancer (46:55) Case: A man in his early 60s with HER2-positive esophageal cancer and isolated brain metastases — Priya Rudolph, MD, PhD (50:07) CME information and select publications
You don't want to solve for this Y, Junior. Not on a full stomach, anyway.We have a lovely set of internet reviews this week, including (but not limited to) Fruit Pebble flavored Sparking Water from Liquid Death, fake mustaches' ability to absorb pacific northwestern goo, being a true human being in 'Wreck It Ralph', and a banana-based health supplement. We also do a deep dive into the late Ace Frehley's concert vibes on Momento Moreview. Do the math!Want more party? Check it out at https://www.reviewpartydotcom.com/ !
In this episode, we review the high-yield topic of Alcoholic Liver Disease from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Hepatitis from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Gastrointestinal bleeding is a frequent and potentially life-threatening presentation in the ED. With CT angiography increasingly being used as a first-line diagnostic tool, are we improving detection or simply overusing imaging? Join Dr. Guillaume as she discusses this recent JAMA Network Open study examining trends in CTA utilization for GI bleeding and whether rising scan rates are truly leading to better diagnostic yield.
In this episode, we review the high-yield topic of Hepatic Encephalopathy from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Diarrhea from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Proton Pump Inhibitors from the Gastrointestinal section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Inflammatory bowel diseases remain challenging for medicine, subjecting many to lifelong healthcare expenses and debilitating complications DMSO is an "umbrella remedy" treating diverse ailments through reducing inflammation, improving circulation, and reviving dying cells, making it uniquely suited for treating gastrointestinal disorders Extensive data shows DMSO produces incredible results for inflammatory bowel disorders (Crohn's disease, ulcerative colitis, IBS, diverticulitis, leaky gut syndrome, SIBO) and effectively protects gastrointestinal tissues from a wide range of otherwise lethal stressors Data also supports using DMSO for severe GI tract issues (gastritis, peptic ulcers, liver cirrhosis, cholecystitis, pancreatitis, peritonitis, amyloidosis) and problems like hemorrhoids and prostate enlargement This article will review how DMSO can be used to treat those conditions
© 2020-2026 Ivy Podcast Discovery LLC
