Podcasts about Lung

Lung cancer, particularly non-small cell lung cancer (NSCLC), is the deadliest cancer worldwide. Cigarette smoking is one of the main causes, but not every smoker develops the disease. This suggests that other biological factors help determine who develops cancer. Researchers from the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indianapolis, and from the Richard L. Roudebush Veterans Affairs Medical Center have now found that cigarette smoke, combined with a weakened DNA repair system, can trigger the early stages of lung cancer, particularly NSCLC. This work, led by first author Nawar Al Nasralla and corresponding author Catherine R. Sears, was recently published in Volume 16 of Oncotarget. Full blog - https://www.oncotarget.org/2025/08/11/cigarette-smoke-and-weak-dna-repair-a-double-hit-behind-lung-cancer-risk/ Paper DOI - https://doi.org/10.18632/oncotarget.28724 Correspondence to - Catherine R. Sears - crufatto@iu.edu Video short - https://www.youtube.com/watch?v=UEiCz834a8c Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28724 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, DNA repair, DNA damage, lung adenocarcinoma, squamous cell carcinoma, Xeroderma Pigmentosum Group C (XPC) To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Lung cancer is one of the deadliest forms of cancer in Canada. While surgery is often the best treatment, it is extremely invasive. Dr. Chris Zhang, a professor in the University of Saskatchewan (USask) College of Engineering, is part of a research team looking to develop a non-invasive tool for removing lung cancer tumours. He joins Evan to share more about the research and how it could change treatment and recovery for cancer patients.

This month KYW Newsradio's Rasa Kaye and Deborah Heart and Lung center Cardiologist Geurys Rojas-Marte, MD discuss how individuals can prevent or manage risk factors for heart failure. They also talk about the latest advancements in heart failure treatment at any stage.

Lung cancer remains one of the deadliest cancers in the United States, in part because it’s often detected too late. On The Spark, UPMC Thoracic Surgeon Dr. Troy Moritz joined the show to shed light on who should be screened, what symptoms not to ignore, and how technology is changing the way lung cancer is detected and treated. Who Should Be Screened? Dr. Moritz emphasized the importance of lung cancer screenings for a specific group:“We’re looking for people that are age 50 to up to 80 years of age and those people that have smoked what we consider to be 20 pack years,” he explained.That includes anyone who smoked a pack a day for 20 years — or an equivalent amount — and hasn’t quit within the last 15 years. These high-risk individuals are encouraged to undergo low-dose CT scans, which Dr. Moritz described as simple and noninvasive.“It’s pretty much just get in the CAT scan machine and buzz in, buzz out,” he said. “It’s not an MRI, so you don’t have to worry about that claustrophobic feeling.”Support WITF: https://www.witf.org/support/give-now/See omnystudio.com/listener for privacy information.

Eco-Business spoke to Hang Lung Properties deputy director of sustainability John Haffner for the latest episode of On the frontlines, which profiles change-makers on the hard edge of sustainable business. Tune as we discuss: Discipline and sustainability spending Are our sustainability targets too weak or too ambitious? How do you justify your job? Managing greenwashing risk Advice for sustainability aspirants Burnout risk

As a member of W.H. Lung, Tom Sharkett has provided electronics for one of the best bands in the UK, including on their most recent, critically acclaimed LP, ‘Every Inch of Earth Pulsates'. These DIY, indie-oriented experimentations have slowly led Sharkett to unexpected places as a solo artist in club culture, via the portal of Manchester's legendary venue, The White Hotel, where he was inspired by inspired by cult nights such as Red Lazer and Wet Play, Sharkett has since collaborated with artists such as System Olympia and Raf Rundell, as well as appearing on Optimo Music and Okay Nature Records. His subtle, spirited edit of LCD Soundsystem's ‘Home', released as a bootleg in early 2025, has recently re-emerged on DFA Records as an official release, just in time to become an unusual wistful summer anthem. Sharkett captures this fruitful moment in a contribution to Phantasy's long-running mix series, which features a smattering of currently unreleased material, while bridging Cabaret Voltaire, Slowdive, Eden Burns and even Chappel Roan. True to the eclectic philosophy of Sharkett's DJ and production trip so far, PHANTASYMIX 53 is a rare trip.

Full article: https://www.ajronline.org/doi/10.2214/AJR.25.33063 Bardia Nadim, MD, discusses the AJR article by Jang et al. exploring real-world results from the use of AI for detecting lung metastases from colorectal cancer.

A new NEJM trial found methotrexate offers similar lung function improvements as prednisone in pulmonary sarcoidosis, but with fewer side effects—suggesting it could be a safer first-line option for some patients. A JAMA study revealed that patients trust physicians less when AI is mentioned in care ads, highlighting the importance of framing AI as a tool that supports—not replaces—clinical judgment. Another NEJM trial showed that giving take-home ondansetron to children after ED visits for gastroenteritis significantly reduced vomiting and return visits, with no added risks. Together, these studies support a shift toward individualized care, better patient communication, and practical interventions to improve outcomes.

In today's episode, we connect with Dr. Aahd Kubbara to discuss the intricacies of lung function and targeted biological therapies for asthma. Dr. Kubbara is a practicing pulmonologist and intensivist at the University of Minnesota Medical Center, where he also serves as an Assistant Professor of Medicine, Pulmonary, Allergy, Critical Care, and Sleep and Associate Program Director of the Pulmonary and Critical Care Fellowship. Hit play to discover: The types of inflammatory diseases that can lead to lung scarring. The consequences of untreated asthma over years of time. What pulmonary fibrosis is, and how to treat it. The potential impacts of normalizing chronic health symptoms. How seasonal asthma is typically triggered and how to mitigate it. Dr. Kubbara brings a wealth of experience to his field, including a year in Critical Care at the Mayo Clinic in Rochester, and another year in Academic Pulmonary and Critical Care at the University of Nevada, Reno. He also spent a year practicing community Pulmonary and Critical Care at both Mayo Clinic Eau Claire and Aspirus Wausau Hospital. In addition, he completed an advanced fellowship in Interstitial Lung Disease and Vasculitis at the Mayo Clinic. To learn more about Dr. Kubbara and his work, click here! Episode also available on Apple Podcasts: http://apple.co/30PvU9C Keep up with Julian R. Gershon Jr. socials here: Instagram: https://www.instagram.com/aahd_kubbara/?hl=en  X : https://x.com/aahdkubbara 

Lung cancer is Australia's fifth most diagnosed cancer, but causes the greatest number of deaths because it is often diagnosed too late. A new screening program has become available from July 1 that hopes to detect cases much earlier for those at the highest risk - which includes Indigenous Australians and some migrant communities. - 肺がんは、オーストラリアで5番目に多く診断されているがんですが、発見が遅れることが多く、がんによる死亡原因の中で最も多くなっています。こうした中、7月1日から新たな肺がんの検診プログラムが始まりました。

Tune in as Alec, Mengyu, Parisa, Ethan, and Ibrahim dissect a case  of a 40 YO M presenting after a motor vehicle collision!  Download CPSolvers App here RLRCPSOLVERS

Microbiome is a mysterious medical frontier with more questions than answers. In this episode, nutrition expert Neal Barnard, MD, of George Washington University explores the connection between diet, gut microbiome and lung health. While fiber and plant-based diets have been shown to shape a healthier microbiome, this conversation sheds light on the growing evidence that what we eat may have far-reaching effects beyond the gut—including in our lungs.

Talking Fantasy Football on The Kenny & JT Show with our good friend Bob Lung from Big Guy Fantasy Sports and bigguyfantasysports.com.

Dr. Mohleen Kang chats with Dr. Anna Podolanczuk and Dr. Gary Hunninghake about their article, "Approach to the Evaluation and Management of Interstitial Lung Abnormalities."

In this episode, I sit down with C. Vivek Lal, MD, FAAP, a physician-scientist and the founder & CEO of Resbiotic, to explore the incredible connection between our gut microbiome and respiratory health.  Dr. Lal shares how his clinical work with premature infants inspired a deeper dive into gut-lung science, ultimately leading to the development of Resbiotic—a science-first wellness brand that's bridging the gap between clinical research and everyday health. What really struck me in this conversation was Vivek's blend of curiosity, care, and credibility. He's not just creating a product—he's on a mission to help people breathe easier, live better, and understand how their gut health plays a role in it all. If you're interested in functional wellness, biotech innovation, or just want to understand your body a bit better, this one is for you. Here are a few highlights from our conversation: * The gut-lung axis: what it is and why it matters * How a NICU doctor became a CPG founder * Why Resbiotic leads with clinical credibility, not marketing fluff * The challenge of translating deep science into consumer products * How education and transparency are building trust in a skeptical market Join me, Ramon Vela, as I listen to the episode and discover how science, storytelling, and heart are driving the next wave of health and wellness innovation. For more on Resbiotic, visit: https://resbiotic.com/ If you enjoyed this episode, please leave The Story of a Brand Show a rating and review.  Plus, don't forget to follow us on Apple and Spotify.  Your support helps us bring you more content like this! * Today's Sponsors: Color More Lines: https://www.colormorelines.com/get-started Color More Lines is a team of ex-Amazonians and e-commerce operators who help brands grow faster on Amazon and Walmart. With a performance-based pricing model and flexible contracts, they've generated triple-digit year-over-year growth for established sellers doing over $5 million per year.   Use code "STORY OF A BRAND” and receive a complimentary market opportunity assessment of your e-commerce brand and marketplace positioning.    1 Commerce: https://1-commerce.com/story-of-a-brand Scaling a DTC brand becomes harder the bigger you grow, especially when you're limited to selling on just one channel.  While you're focused on day-to-day ops, your competitors are unlocking marketplaces like Amazon, Walmart, and even retail shelf space—and capturing customers you're missing. That's where 1-Commerce comes in.  They help high-growth brands expand beyond their sites, handle end-to-end fulfillment, and scale through a revenue-share model that means they only win when you do.  As a Story of a Brand listener, you'll get one month of free storage and a strategy session with their CEO, Eric Kasper.

On this episode of Translating Proteomics, Parag, Andreas, and special guest Don Kirkpatrick answer questions submitted by the Translating Proteomics community. They cover:Needs in plasma proteomicsHow proteomics impacts drug development – with special guest Don Kirkpatrick Ph.D.!How lifestyle impacts the proteomeHow the Nautilus Proteome Analysis Platform is impacting tau and Alzheimer's disease researchReferencesShome et al., 2022 - Serum autoantibodyome reveals that healthy individuals share common autoantibodieshttps://www.sciencedirect.com/science/article/pii/S2211124722006489LaBaer Lab paper investigating autoantibody levels in plasma and their relationship to health.Sylman et al., 2018 - A Temporal Examination of Platelet Counts as a Predictor of Prognosis in Lung, Prostate, and Colon Cancer Patientshttps://www.nature.com/articles/s41598-018-25019-1Mallick lab paper investigating temporal changes in platelets and their associations with cancer biology.Krönke et al., 2014 - Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cellshttps://www.science.org/doi/10.1126/science.1244851Seminal paper describing selective protein degradation caused by lenalidomide.Fink and Ebert 2015 - The novel mechanism of lenalidomide activityhttps://ashpublications.org/blood/article/126/21/2366/34644/The-novel-mechanism-of-lenalidomide-activityReview of research elucidating the mechanisms of lenalidomide activityNdoja et al., 2025 - COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathwayhttps://www.mdpi.com/2073-4409/14/13/975Describe links between kinase inhibitor vemurafenib and changes in ETV transcription factor degradationSong et al., 2022 - RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacyhttps://aacrjournals.org/cancerdiscovery/article/12/1/204/675622/RTK-Dependent-Inducible-Degradation-of-Mutant-PI3KUse proteomics to discover that inavolisib acts through selective degradation of mutant PI3KαCanon et al., 2019 - The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunityhttps://www.nature.com/articles/s41586-019-1694-1Covers the development of an inhibitor of KRAS mutant KRAS (G12C).Schneider et al., 2024 - Feeding gut microbes to nourish the brain: unravelling the diet-microbiota-gut-brain axishttps://www.nature.com/articles/s42255-024-01108-6Review on the gut-brain axisWebpage for Johanna Lampe's Lab at Fred Hutch Cancer Center

Lung cancer has a high chance of relapse, so how do we get out of ahead of it? Nancy Guo, SUNY Empire Innovation Professor in the school of computing at Binghamton University, discusses technology that helps us do so. Nancy Guo is one of the newest additions to the Binghamton University School of Computing as […]

The boys are back with another outstanding guest. The King of Consistency Bob Lung is in the house to iron out who to draft based on consistency, who are some players carrying red flags, and where there is hidden value in 2025. This is not a show you want to miss as we gear up getting you ready for 2025.And... stay tuned until the very end as we drop a very special surprise!!Bob's Guide can be found here Hosted on Acast. See acast.com/privacy for more information.

In this episode, hosts Kyle Kruse and Richard Meiklejohn are joined by Doug Evans, CEO of Lungpacer, to discuss innovative breakthroughs in respiratory care. Doug outlines the critical issue of mechanical ventilation, which affects 2 million patients annually in the U.S., with a 40% mortality rate among them. He provides detailed insights into how Lungpacer's neurostimulation technology aims to improve patient outcomes by maintaining diaphragm muscle function, thereby reducing time on ventilators and minimizing the need for reintubation. The discussion covers the rigorous research and FDA approval process, as well as the forthcoming Aero Nova system designed to assist patients from the onset of mechanical ventilation. Doug also shares the company's plans for commercialization, manufacturing scale-up, and future clinical milestones. The conversation highlights the potential impact of Lungpacer's technology on patient survival rates and healthcare costs, positioning it as a transformative solution in critical care, a story sure to leave you informed and inspired.

In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Black cumin on Lung Health CytoSolve Systems Analysis

About this episode: Asthma can cause sometimes debilitating symptoms for children who have it, and some—particularly Black and Hispanic children—can experience higher rates of diagnoses, hospitalizations and emergency department visits. In this episode: pediatrician and immunology researcher Dr. Elizabeth Matsui talks about the known causes behind childhood asthma and how it impacts youths, and how factors like poor housing conditions and barriers to care and medication worsen conditions and undermine long-term lung development. Guest: Dr. Elizabeth Matsui is a pediatric allergist-immunologist and epidemiologist and a leading researcher on the connection between asthma and environmental conditions. Host: Stephanie Desmon, MA, is a former journalist, author, and the director of public relations and communications for the Johns Hopkins Center for Communication Programs at the Johns Hopkins Bloomberg School of Public Health. Show links and related content: The Role of Neighborhood Air Pollution in Disparate Racial and Ethnic Asthma Acute Care Use—American Journal of Respiratory and Critical Care Medicine Association of a Housing Mobility Program With Childhood Asthma Symptoms and Exacerbations—JAMA Do upper respiratory viruses contribute to racial and ethnic disparities in emergency department visits for asthma?—The Journal of Allergy and Clinical Immunology Tackling Housing Injustice—and Improving Childhood Asthma—Public Health On Call (June 2023) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌JohnsHopkinsSPH on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University

Australians at higher risk of lung cancer are being urged to take advantage of a new screening program that has launched this month. The scan will be free for patients under Medicare bulk-billing through GPs, with eligibility to be determined by age - those between 50 and 70 - and smoking history. It is the first new national cancer screening program in nearly 20 years. Lung cancer is Australia's fifth most diagnosed cancer, but causes the greatest number of cancer deaths because it is often diagnosed too late. SBS's Biwa Kwan spoke with Anita Dessaix from the Cancer Council, about the at-risk groups the program is targeting; and the goal to prevent over 12,000 deaths over a decade

Lung cancer is Australia's fifth most diagnosed cancer, but causes the greatest number of deaths because it is often diagnosed too late. A new screening program has become available that hopes to detect cases much earlier for those at the highest risk - which includes Indigenous Australians and some migrant communities.

In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Astragalus on Lung Health CytoSolve Systems Analysis

We're getting by with our Collapsible Lung, and it's a good time 100% of the time... or is it? Take a breath and then take it in because we're covering Relient K's most controversial record. Does this episode have Disaster written all over it, or will we find this record Sweeter than we remember? Snap back, snap back, here we go again.If you like what you hear, please rate, review, subscribe, and follow!Connect with us here:Email: contact@churchjamsnow.comSite: https://www.churchjamsnow.com/IG: @churchjamsnowTwitter: @churchjamsnowFB: https://www.facebook.com/churchjamsnowpodcastPatreon: https://www.patreon.com/churchjamsnowpodcast

Granulomatosis with Polyangiitis (GPA) – Recognition and Management in the ED Hosts: Phoebe Draper, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/GPA.mp3 Download Leave a Comment Tags: Rheumatology Show Notes Background A vasculitis affecting small blood vessels causing inflammation and necrosis Affects upper respiratory tract (sinusitis, otitis media, saddle nose deformity), lungs (nodules, alveolar hemorrhage), and kidneys (rapidly progressive glomerulonephritis) Can lead to multi-organ failure, pulmonary hemorrhage, renal failure Red Flag Symptoms: Chronic sinus symptoms Hemoptysis (especially bright red blood) New pulmonary complaints Renal dysfunction Constitutional symptoms (fatigue, weight loss, fever) Workup in the ED: CBC, CMP for anemia and AKI Urinalysis with microscopy (hematuria, RBC casts) Chest imaging (CXR or CT for nodules, cavitary lesions) ANCA testing (not immediately available but important diagnostically) Management: Stable patients: Outpatient workup, urgent rheumatology consult, prednisone 1 mg/kg/day Unstable patients: High-dose IV steroids (methylprednisolone 1 g daily x3 days), consider plasma exchange, cyclophosphamide or rituximab initiation, ICU admission Conditions that Mimic GPA: Goodpasture syndrome (anti-GBM antibodies) TB, fungal infections Lung malignancy Other vasculitides (EGPA, MPA, lupus)

People with lung conditions like asthma or chronic obstructive pulmonary disease, abbreviated COPD, rely on air conditioning in the summer to help keep their symptoms from getting much worse. William Checkley, a lung health expert at Johns Hopkins, says it's … If you don't use AC properly you may make lung problems worse, Elizabeth Tracey reports Read More »

If you have any respiratory issues you likely benefit from air conditioning when the weather is hot. Lung health expert William Checkley at Johns Hopkins says you must be aware of the system's maintenance requirements to reap its benefits. Checkley: … Proper AC maintenance is key to healthful use, Elizabeth Tracey reports Read More »

Substack is where I discovered Dr. MeiLan Han! I was browsing through and was pleasantly surprised to read an article, and learn that she wrote a book called, Breathing Lessons. And to top it off, she's from my home state of Michigan. I also learned the Dr. Han's book was “a passion project during the pandemic.”I'm delighted to share a conversation with Dr. MeiLan Han, one of the country's most respected voices in lung health and a tireless advocate for people living with chronic respiratory conditions.Dr. Han is a Professor of Medicine and Chief of Pulmonary and Critical Care at University of Michigan Health. She's not only cared for patients at the bedside but has devoted her career to understanding lung disease at its roots, with a special focus on chronic obstructive pulmonary disease (COPD), a condition that remains widely under-recognized and underfunded. Through her research, Dr. Han is helping to uncover how diseases like COPD affect the lungs in different ways, with the goal of making treatment more precise, more effective, and more personalized.Her journey began at the University of Washington and continued through specialized training at the University of Michigan, where she also earned a Master's degree in Biostatistics and Clinical Study Design. Today, she leads research funded by the National Institutes of Health (NIH), serves on national advisory boards for the COPD Foundation and the American Lung Association, and contributes to global guidelines that shape how lung disease is diagnosed and treated.Dr. Han also serves as Deputy Editor of the American Journal of Respiratory and Critical Care Medicine, helping to guide the direction of clinical practice and research in pulmonary medicine.If you or someone you love is living with a chronic lung condition, Dr. Han's insight is not only encouraging, it's essential. I'm so grateful to bring her voice to this platform. How many breathes do we take in a lifetime? It's fascinating to discuss and you'll hear the answer in our podcast.Lung health, do you think about it?To get her book: https://www.amazon.com/Breathing-Lessons-Doctors-Guide-Health-ebook/dp/B08X2ZFGNZ/ref=tmm_kin_swatch_0 Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en

This Week: Catching Nathan Off Guard, Getting Dudes Drunk and Touching Their Junk, Churchy Reddit, In Utero Rules, Nathan Don't Practice Santeria, Songs About Pants, My Sweet Lord, Dr. Pepper, Choking to Death on Pull And Peel, A Single Skin Flap Keeping Us All Alive, Local Sexpot Dies, Blue Collar Comedy, Learn to Laugh At Yourself, The Two Popes. Recorded: 06/08/2025Get on the Patreon Train: https://patreon.com/Sushijackknife?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLinkBandcamp Store: https://sushijackknife.bandcamp.com/Email: sushijackknife@gmail.com

Episode 72 - VERITAS - CT vs. Scope Lung Biopsy Showdown by AABIP

Since that first interview, Richard has faced multiple cancer recurrences—including brain tumors and cancer in his remaining lung—and continues to rely on cannabis oil as a central part of his healing. In this episode, he talks candidly about living with cancer, navigating the challenges of legalization, dealing with skeptical doctors, and staying grounded with family, humour, and positivity.00:37 – Introduction to Richard Lusk and his original interview from 201601:17 – How Richard first discovered his lung cancer02:45 – Starting cannabis oil and watching tumors shrink03:45 – Leaving Washington to care for his mother in Kansas—cannabis access cut off04:30 – Cancer returns and spreads to his brain05:38 – Returning to Washington for treatment and cannabis access06:10 – Telling his oncologist about cannabis oil07:02 – Doctors say it's incurable—Richard disagrees07:53 – How he takes a gram of cannabis oil each day08:54 – Symptoms that led to brain tumor discovery09:39 – Years in construction and staying physically resilient10:28 – Emotional vs. physical challenges of illness11:40 – Thoughts on legal cannabis access across the U.S.12:57 – Adrenal gland cancer and additional surgeries13:44 – Belief in cannabis over conventional treatments16:07 – The role of cannabis in surviving cancer17:40 – Advice for people newly diagnosed with cancer18:41 – Staying positive and the importance of family20:52 – Choosing your own path despite family opposition21:12 – Current restrictions and chemo side effects22:48 – Gratitude for life and simple pleasures23:26 – A brain surgeon's 6.5 rating and Richard's humour24:38 – Final thoughts, hope for change, and sharing his story Visit our website: CannabisHealthRadio.comDiscover products and get expert advice from Swan ApothecaryFollow us on Facebook.Follow us on Instagram.Find us on Rumble.Keep your privacy! Buy NixT420 Odor Remover

Tanzira Zaman, MD and Elizabeth Volkmann, MD, MS discuss the new official American Thoracic Society Clinical Statement on the diagnosis and management of interstitial lung abnormalities which Dr. Podolanczuk presented at ATS 2025.

In the third episode of our lung cancer miniseries, Jonathan Sackier is joined by Douglas E. Wood, Henry N. Harkins Professor and Chair of Surgery at the University of Washington. A global leader in thoracic oncology, Wood explores the critical role of lung cancer staging, the evolution of screening guidelines, and how surgical innovation is shaping the future of lung cancer treatment. Timestamps: 00:00 – Introduction 02:37 – Career beginnings 07:37 – Career highlights 11:38 – Thoracic oncology guidelines 15:26 – AI and big data 17:17 – Expanding lung cancer screening 19:29 – Robotic surgery 23:38 – Targeted therapies 27:23 – Cancer staging 30:44 – Lung volume reduction surgery 35:10 – Current trials 40:50 – Three wishes for healthcare

282: If you suffer from asthma, allergies, chronic coughs, or are sensitive to smoke and pollution... heck, even if you have gut issues, this episode will blow your mind! I bet you didn't know that our gut health affects our lung health and vice versa! But think about it—if our gut impacts our brain, our skin, and even our mouth, why wouldn't it also affect our lungs? In fact, our lungs require certain probiotics that our gut does not, and that's exactly what we're diving into today: how to support our lungs by supporting our gut with specific probiotics and GLP-1-supporting products. Not GLP-1 drugs like Ozempic! These are natural products that support the GLP-1 our bodies already produce, without side effects. I'm joined by Kara from ResBiotic to help shed light on the connection between lung health, gut health, and weight management. Topics Discussed: → The gut-lung axis → Our lung microbiome → How SCFAs (short-chain fatty acids) aid in lung health → Where SCFAs come from → Probiotics for our lungs → Signs and symptoms of compromised lungs → Foods that support lung health → GLP-1 support → Why gut health influences weight loss or gain → How to lose weight by changing our gut microbiome As always, if you have any questions for the show please email us at digestthispod@gmail.com.  And if you like this show, please share it, rate it, review it and subscribe to it on your favorite podcast app.  Sponsored By: → resbiotic | https://resbiotic.com/ and use code DIGESTTHIS for 20% off Check Out Bethany: → Bethany's Instagram: @lilsipper → YouTube → Bethany's Website → Discounts & My Favorite Products → My Digestive Support Protein Powder → Gut Reset Book  → Get my Newsletters (Friday Finds)

Lung-protective ventilation (LPV), characterized by low tidal volumes and appropriate PEEP, is a cornerstone in managing patients with acute respiratory distress syndrome (ARDS). However, its application in patients with severe acute brain injury raises concerns. The potential for lung protective ventilation to increase intracranial pressure due to hypercapnia and elevated PEEP levels necessitates a closer examination of its safety and efficacy in this unique patient population.

ICYMI: Hour One of ‘Later, with Mo'Kelly' Presents – Thoughts on California's new weather tracking system that categorizes extreme heat factors, AND the latest in California's robotaxi expansion with the massive rollout of Volkswagens new autonomous vehicle fleet…PLUS – A look at California's ranking on the list of states with the healthiest lungs - on KFI AM 640…Live everywhere on the iHeartRadio app & YouTube @MrMoKelly

This week, we present an inspiring episode for anyone interested in the history, present, and future of prostate cancer care. In this Legends in Urology installment of the BackTable Urology Podcast, Dr. Gerald Andriole joins guest host Dr. Niraj Badhiwala to reflect on a career that has left a lasting impact on the field. --- SYNPOSIS Dr. Andriole shares personal stories from his upbringing in Northeastern Pennsylvania and his journey into medicine. He reflects on his expedited education through Penn State and Jefferson Medical College and his path to urology. He discusses his pivotal work in prostate cancer screening, including the influence of major trials like The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, and traces the evolution of surgical and diagnostic techniques. The conversation also touches on current innovations and the future of prostate cancer management, offering valuable advice for the next generation of urologists. --- TIMESTAMPS 00:00 - Introduction01:59 - From Childhood to Medical School06:48 - Discovering Urology16:52 - Pioneering Prostate Cancer Screening24:07 - The PLCO Study: Design and Challenges28:57 - Controversies and Criticisms in Prostate Cancer Screening33:29 - Evolving Practices in Prostate Cancer Management44:19 - Future of Prostate Cancer Treatment

Today's guest is the author of the Fantasy Football Consistency Guide (available on Amazon) and the founder of the Fantasy Football Expo in Canton, OH which will be held August 8th-10th.

Being short of breath is a terrible feeling, most people agree, and it's a feature of many lung diseases, especially as they progress. Lung expert Anna Gersten at Johns Hopkins describes how a breathlessness clinic came to be at Hopkins … What is a breathlessness clinic? Elizabeth Tracey reports Read More »

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3012: Dr. Neal breaks down the role of genetics in cholesterol levels and explains how even those with a family history of heart disease can benefit from targeted lifestyle changes. From diet tweaks to exercise strategies, his practical tips empower listeners to take control of their heart health, no matter their DNA. Quotes to ponder: "HDL actually helps the body clear LDL from the arteries, which is why it's good." "One of the most effective ways to lower blood cholesterol and blood pressure quickly is weight loss." "Fiber is so helpful because it helps bind to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids (NIH Office of Dietary Supplements): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer USDA FoodData Central: https://fdc.nal.usda.gov/ National Heart, Lung, and Blood Institute: https://www.nhlbi.nih.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3012: Dr. Neal breaks down the role of genetics in cholesterol levels and explains how even those with a family history of heart disease can benefit from targeted lifestyle changes. From diet tweaks to exercise strategies, his practical tips empower listeners to take control of their heart health, no matter their DNA. Quotes to ponder: "HDL actually helps the body clear LDL from the arteries, which is why it's good." "One of the most effective ways to lower blood cholesterol and blood pressure quickly is weight loss." "Fiber is so helpful because it helps bind to cholesterol and helps the body get rid of it." Episode references: Omega-3 Fatty Acids (NIH Office of Dietary Supplements): https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer USDA FoodData Central: https://fdc.nal.usda.gov/ National Heart, Lung, and Blood Institute: https://www.nhlbi.nih.gov Learn more about your ad choices. Visit megaphone.fm/adchoices

BUFFALO, NY - June 11, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 29, 2025, titled “Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib.” A team led by first author Jinah Kim, from the University of Vermont Medical Center, and corresponding author Young Kwang Chae, from the Feinberg School of Medicine, reports a clinical case in which a patient with advanced non-small cell lung cancer (NSCLC) carrying rare EGFR mutations responded remarkably to amivantamab after other treatments had failed. The patient experienced a complete resolution of brain and spinal fluid metastases, suggesting that amivantamab may be a viable option for patients with uncommon genetic profiles and limited therapy options. Lung cancer remains one of the leading causes of cancer-related deaths worldwide. Patients with NSCLC who have rare mutations in the EGFR gene often face limited treatment options and poor outcomes, especially when the disease spreads to the brain or spinal fluid. This case involved a 67-year-old man diagnosed with NSCLC who had two rare EGFR mutations—G719A and A289V. After disease progression on osimertinib and other therapies, the patient began amivantamab monotherapy. Within six weeks, his lung tumor shrank by over 30 percent. By six months, imaging confirmed the disappearance of brain metastases and leptomeningeal disease, a serious condition affecting the membranes of the brain and spinal cord. Blood tests showed no detectable cancer-related mutations, and the patient, previously wheelchair-bound, regained the ability to walk and perform daily activities. This response has been sustained for more than 19 months. “Treatment produced a durable response over 19 months, including a 32.2% reduction in tumor size at six weeks, and complete resolution of brain metastases and LMD by six months.” Amivantamab is a bispecific antibody that targets EGFR and MET, two key drivers of tumor growth. While it is approved in combination regimens for common EGFR mutations, its effectiveness as a single agent in rare mutations or in treating brain metastases remains largely unproven. This case challenges the assumption that large antibody drugs cannot cross the blood-brain barrier and suggests that amivantamab may have potential in managing central nervous system involvement. Further research is needed to clarify how the drug achieves these effects and to explore its broader use in patients with rare EGFR mutations and limited treatment options. This case highlights three key findings: amivantamab may be effective against rare EGFR mutations, can be used as monotherapy, and may overcome the challenges of the blood-brain barrier. Although based on a single patient, the results provide encouraging evidence to support further investigation of amivantamab in treating difficult-to-manage forms of NSCLC. DOI - https://doi.org/10.18632/oncotarget.28730 Correspondence to - Young Kwang Chae - young.chae@northwestern.edu Video short - https://www.youtube.com/watch?v=RJX3rmtH7h8 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, amivantamab, monotherapy, rare EGFR mutation, NSCLC, leptomeningeal disease To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Author: Eric R. Heinz, MD, PhD, George Washington University, Washington, DC Section Editor: Yuriy Bronshteyn

Dr. Nathan Pennell and Dr. Cheryl Czerlanis discuss challenges in lung cancer screening and potential solutions to increase screening rates, including the use of AI to enhance risk prediction and screening processes. Transcript Dr. Nate Pennell: Hello, and welcome to By the Book, a monthly podcast series for ASCO Education that features engaging discussions between editors and authors from the ASCO Educational Book. I'm Dr. Nate Pennell, the co-director of the Cleveland Clinic Lung Cancer Program and vice chair of clinical research for the Taussig Cancer Center. I'm also the editor-in-chief for the ASCO Educational Book.  Lung cancer is one of the leading causes of cancer-related mortality worldwide, and most cases are diagnosed at advanced stages where curative treatment options are limited. On the opposite end, early-stage lung cancers are very curable. If only we could find more patients at that early stage, an approach that has revolutionized survival for other cancer types such as colorectal and breast cancer.  On today's episode, I'm delighted to be joined by Dr. Cheryl Czerlanis, a professor of medicine and thoracic medical oncologist at the University of Wisconsin Carbone Cancer Center, to discuss her article titled, "Broadening the Net: Overcoming Challenges and Embracing Novel Technologies in Lung Cancer Screening." The article was recently published in the ASCO Educational Book and featured in an Education Session at the 2025 ASCO Annual Meeting. Our full disclosures are available in the transcript of this episode.  Cheryl, it's great to have you on the podcast today. Thanks for being here. Dr. Cheryl Czerlanis: Thanks, Nate. It's great to be here with you. Dr. Nate Pennell: So, I'd like to just start by asking you a little bit about the importance of lung cancer screening and what evidence is there that lung cancer screening is beneficial. Dr. Cheryl Czerlanis: Thank you. Lung cancer screening is extremely important because we know that lung cancer survival is closely tied to stage at diagnosis. We have made significant progress in the treatment of lung cancer, especially over the past decade, with the introduction of immunotherapies and targeted therapies based on personalized evaluation of genomic alterations. But the reality is that outside of a lung screening program, most patients with lung cancer present with symptoms related to advanced cancer, where our ability to cure the disease is more limited.  While lung cancer screening has been studied for years, the National Lung Screening Trial, or the NLST, first reported in 2011 a significant reduction in lung cancer deaths through screening. Annual low-dose CT scans were performed in a high-risk population for lung cancer in comparison to chest X-ray. The study population was comprised of asymptomatic persons aged 55 to 74 with a 30-pack-year history of smoking who were either active smokers or had quit within 15 years. The low-dose CT screening was associated with a 20% relative risk reduction in lung cancer-related mortality. A similar magnitude of benefit was also reported in the NELSON trial, which was a large European randomized trial comparing low-dose CT with a control group receiving no screening. Dr. Nate Pennell: So, this led, of course, to approval from CMS (Centers for Medicare and Medicaid Services) for lung cancer screening in the Medicare population, probably about 10 years ago now, I think. And there are now two major trials showing an unequivocal reduction in lung cancer-related mortality and even evidence that it reduces overall mortality with lung cancer screening. But despite this, lung cancer screening rates are very low in the United States. So, first of all, what's going on? Why are we not seeing the kinds of screening rates that we see with mammography and colonoscopy? And what are the barriers to that here? Dr. Cheryl Czerlanis: That's a great question. Thank you, Nate. In the United States, recruitment for lung cancer screening programs has faced numerous challenges, including those related to socioeconomic, cultural, logistical, and even racial disparities. Our current lung cancer screening guidelines are somewhat imprecise and often fail to address differences that we know exist in sex, smoking history, socioeconomic status, and ethnicity. We also see underrepresentation in certain groups, including African Americans and other minorities, and special populations, including individuals with HIV. And even where lung cancer screening is readily available and we have evidence of its efficacy, uptake can be low due to both provider and patient factors. On the provider side, barriers include having insufficient time in a clinic visit for shared decision-making, fear of missed test results, lack of awareness about current guidelines, concerns about cost, potential harms, and evaluating both true and false-positive test results.  And then on the patient side, barriers include concerns about cost, fear of getting a cancer diagnosis, stigma associated with tobacco smoking, and misconceptions about the treatability of lung cancer. Dr. Nate Pennell: I think those last two are really what make lung cancer unique compared to, say, for example, breast cancer, where there really is a public acceptance of the value of mammography and that breast cancer is no one's fault and that it really is embraced as an active way you can take care of yourself by getting your breast cancer screening. Whereas in lung cancer, between the stigma of smoking and the concern that, you know, it's a death sentence, I think we really have some work to be made up, which we'll talk about in a minute about what we can do to help improve this.  Now, that's in the U.S. I think things are probably, I would imagine, even worse when we leave the U.S. and look outside, especially at low- and middle-income countries. Dr. Cheryl Czerlanis: Yes, globally, this issue is even more complex than it is in the United States. Widespread implementation of low-dose CT imaging for lung cancer screening is limited by manpower, infrastructure, and economic constraints. Many low- and middle-income countries even lack sufficient CT machines, trained personnel, and specialized facilities for accurate and timely screenings. Even in urban centers with advanced diagnostic facilities, the high screening and follow-up care costs can limit access. Rural populations face additional barriers, such as geographic inaccessibility of urban centers, transportation costs, language barriers, and mistrust of healthcare systems. In addition, healthcare systems in these regions often prioritize infectious diseases and maternal health, leaving limited room for investments in noncommunicable disease prevention like lung cancer screening. Policymakers often struggle to justify allocating resources to lung cancer screening when immediate healthcare needs remain unmet. Urban-rural disparities exacerbate these challenges, with rural regions frequently lacking the infrastructure and resources to sustain screening programs. Dr. Nate Pennell: Well, it's certainly an intimidating problem to try to reduce these disparities, especially between the U.S. and low- and middle-income countries. So, what are some of the potential solutions, both here in the U.S. and internationally, that we can do to try to increase the rates of lung cancer screening? Dr. Cheryl Czerlanis: The good news is that we can take steps to address these challenges, but a multifaceted approach is needed. Public awareness campaigns focused on the benefits of early detection and dispelling myths about lung cancer screening are essential to improving participation rates. Using risk-prediction models to identify high-risk individuals can increase the efficiency of lung cancer screening programs. Automated follow-up reminders and screening navigators can also ensure timely referrals and reduce delays in diagnosis and treatment. Reducing or subsidizing the cost of low-dose CT scans, especially in low- or middle-income countries, can improve accessibility. Deploying mobile CT scanners can expand access to rural and underserved areas.  On a global scale, integrating lung cancer screening with existing healthcare programs, such as TB or noncommunicable disease initiatives, can enhance resource utilization and program scalability. Implementing lung cancer screening in resource-limited settings requires strategic investment, capacity building, and policy interventions that prioritize equity. Addressing financial constraints, infrastructure gaps, and sociocultural barriers can help overcome existing challenges. By focusing on cost-effective strategies, public awareness, and risk-based eligibility criteria, global efforts can promote equitable access to lung cancer screening and improve outcomes.  Lastly, as part of the medical community, we play an important role in a patient's decision to pursue lung cancer screening. Being up to date with current lung cancer screening recommendations, identifying eligible patients, and encouraging a patient to undergo screening often is the difference-maker. Electronic medical record (EMR) systems and reminders are helpful in this regard, but relationship building and a recommendation from a trusted provider are really essential here. Dr. Nate Pennell: I think that makes a lot of sense. I mean, there are technology improvements. For example, our lung cancer screening program at The Cleveland Clinic, a few years back, we finally started an automated best practice alert in our EMR for patients who met the age and smoking requirements, and it led to a six-fold increase in people referred for screening. But at the same time, there's a difference between just getting this alert and putting in an order for lung cancer screening and actually getting those patients to go and actually do the screening and then follow up on it. And that, of course, requires having that relationship and discussion with the patient so that they trust that you have their best interests. Dr. Cheryl Czerlanis: Exactly. I think that's important. You know, certainly, while technology can aid in bringing patients in, there really is no substitute for trust-building and a personal relationship with a provider. Dr. Nate Pennell: I know that there are probably multiple examples within the U.S. where health systems or programs have put together, I would say, quality improvement projects to try to increase lung cancer screening and working with their community. There's one in particular that you discuss in your paper called the "End Lung Cancer Now" initiative. I wonder if you could take us through that. Dr. Cheryl Czerlanis: Absolutely. "End Lung Cancer Now" is an initiative at the Indiana University Simon Comprehensive Cancer Center that has the vision to end suffering and death from lung cancer in Indiana through education and community empowerment. We discuss this as a paradigm for how community engagement is important in building and scaling a lung cancer screening program.  In 2023, the "End Lung Cancer Now" team decided to focus its efforts on scaling and transforming lung cancer screening rates in Indiana. They developed a task force with 26 experts in various fields, including radiology, pulmonary medicine, thoracic surgery, public health, and advocacy groups. The result of this work is an 85-page blueprint with key recommendations that any system and community can use to scale lung cancer screening efforts. After building strong infrastructure for lung cancer screening at Indiana University, they sought to understand what the priorities, resources, and challenges in their communities were. To do this, they forged strong partnerships with both local and national organizations, including the American Lung Association, American Cancer Society, and others. In the first year, they actually tripled the number of screening low-dose CTs performed in their academic center and saw a 40% increase system-wide. One thing that I think is the most striking is that through their community outreach, they learned that most people prefer to get medical care close to home within their own communities. Establishing a way to support the local infrastructure to provide care became far more important than recruiting patients to their larger system.  In exciting news, "End Lung Cancer Now" has partnered with the IU Simon Comprehensive Cancer Center and IU Health to launch Indiana's first and only mobile lung screening program in March of 2025. This mobile program travels around the state to counties where the highest incidence of lung cancer exists and there is limited access to screening. The mobile unit parks at trusted sites within communities and works in partnership, not competition, with local health clinics and facilities to screen high-risk populations. Dr. Nate Pennell: I think that sounds like a great idea. Screening is such an important thing that it doesn't necessarily have to be owned by any one particular health system for their patients. I think. And I love the idea of bringing the screening to patients where they are. I can speak to working in a regional healthcare system with a main campus in the downtown that patients absolutely hate having to come here from even 30 or 40 minutes away, and they'd much rather get their care locally. So that makes perfect sense.  So, under the current guidelines, there are certainly things that we can do to try to improve capturing the people that meet those. But are those guidelines actually capturing enough patients with lung cancer to make a difference? There certainly are proposals within patient advocacy communities and even other countries where there's a large percentage of non-smokers who perhaps get lung cancer. Can we expand beyond just older, current and heavy smokers to identify at-risk populations who could benefit from screening? Dr. Cheryl Czerlanis: Yes, I think we can, and it's certainly an active area of research interest. We know that tobacco is the leading cause of lung cancer worldwide. However, other risk factors include secondhand smoke, family history, exposure to environmental carcinogens, and pulmonary diseases like COPD and interstitial lung disease. Despite these known associations, the benefit of lung cancer screening is less well elucidated in never-smokers and those at risk of developing lung cancer because of family history or other risk factors. We know that the eligibility criteria associated with our current screening guidelines focus on age and smoking history and may miss more than 50% of lung cancers. Globally, 10% to 25% of lung cancer cases occur in never-smokers. And in certain parts of the world, like you mentioned, Nate, such as East Asia, many lung cancers are diagnosed in never-smokers, especially in women. Risk-prediction models use specific risk factors for lung cancer to enhance individual selection for screening, although they have historically focused on current or former smokers.  We know that individuals with family members affected by lung cancer have an increased risk of developing the disease. To this end, several large-scale, single-arm prospective studies in Asia have evaluated broadening screening criteria to never-smokers, with or without additional risk factors. One such study, the Taiwan Lung Cancer Screening in Never-Smoker Trial, was a multicenter prospective cohort study at 17 medical centers in Taiwan. The primary outcome of the TALENT trial was lung cancer detection rate. Eligible patients aged 55 to 75 had either never smoked or had a light and remote smoking history. In addition, inclusion required one or more of the following risk factors: family history of lung cancer, passive smoke exposure, history of TB or COPD, a high cooking index, which is a metric that quantifies exposure to cooking fumes, or a history of cooking without ventilation. Participants underwent low-dose CT screening at baseline, then annually for 2 years, and then every 2 years for up to 6 years. The lung cancer detection rate was 2.6%, which was higher than that reported in the NLST and NELSON trials, and most were stage 0 or I cancers. Subsequently, this led to the Taiwan Early Detection Program for Lung Cancer, a national screening program that was launched in 2022, targeting 2 screening populations: individuals with a heavy history of smoking and individuals with a family history of lung cancer.  We really need randomized controlled trials to determine the true rates of overdiagnosis or finding cancers that would not lead to morbidity or mortality in persons who are diagnosed, and to establish whether the high lung detection rates are associated with a decrease in lung cancer-related mortality in these populations. However, the implementation of randomized controlled low-dose CT screening trials in never-smokers has been limited by the need for large sample sizes, lengthy follow-up, and cost.  In another group potentially at higher risk for developing lung cancer, the role of lung cancer screening in individuals who harbor germline pathogenic variants associated with lung cancer also needs to be explored further. Dr. Nate Pennell: We had this discussion when the first criteria came out because there have always been risk-based calculators for lung cancer that certainly incorporate smoking but other factors as well and have discussion about whether we should be screening people based on their risk and not just based on discrete criteria such as smoking. But of course, the insurance coverage for screening, you have to fit the actual criteria, which is very constrained by age and smoking history. Do you think in the U.S. there's hope for broadening our screening beyond NLST and NELSON criteria? Dr. Cheryl Czerlanis: I do think at some point there is hope for broadening the criteria beyond smoking history and age, beyond the criteria that we have typically used and that is covered by insurance. I do think it will take some work to perhaps make the prediction models more precise or to really understand who can benefit. We certainly know that there are many patients who develop lung cancer without a history of smoking or without family history, and it would be great if we could diagnose more patients with lung cancer at an earlier stage. I think this will really count on there being some work towards trying to figure out what would be the best population for screening, what risk factors to look for, perhaps using some new technologies that may help us to predict who is at risk for developing lung cancer, and trying to increase the group that we study to try and find these early-stage lung cancers that can be cured. Dr. Nate Pennell: Part of the reason we, of course, try to enrich our population is screening works better when you have a higher pretest probability of actually having cancer. And part of that also is that our technology is not that great. You know, even in high-risk patients who have CT scans that are positive for a screen, we know that the vast majority of those patients with lung nodules actually don't have lung cancer. And so you have to follow them, you have to use various models to see, you know, what the risk, even in the setting of a positive screen, is of having lung cancer.  So, why don't we talk about some newer tools that we might use to help improve lung cancer screening? And one of the things that everyone is super excited about, of course, is artificial intelligence. Are there AI technologies that are helping out in early detection in lung cancer screening? Dr. Cheryl Czerlanis: Yes, that's a great question. We know that predicting who's at risk for lung cancer is challenging for the reasons that we talked about, knowing that there are many risk factors beyond smoking and age that are hard to quantify. Artificial intelligence is a tool that can help refine screening criteria and really expand screening access. Machine learning is a form of AI technology that is adept at recognizing patterns in large datasets and then applying the learning to new datasets. Several machine learning models have been developed for risk stratification and early detection of lung cancer on imaging, both with and without blood-based biomarkers. This type of technology is very promising and can serve as a tool that helps to select individuals for screening by predicting who is likely to develop lung cancer in the future.  A group at Massachusetts General Hospital, represented in our group for this paper by my co-authors, Drs. Fintelmann and Chang, developed Sybil, which is an open-access 3D convolutional neural network that predicts an individual's future risk of lung cancer based on the analysis of a single low-dose CT without the need for human annotation or other clinical inputs. Sybil and other machine learning models have tremendous potential for precision lung cancer screening, even, and perhaps especially, in settings where expert image interpretation is unavailable. They could support risk-adapted screening schedules, such as varying the frequency and interval of low-dose CT scans according to individual risk and potentially expand lung cancer screening eligibility beyond age and smoking history. Their group predicts that AI tools like Sybil will play a major role in decoding the complex landscape of lung cancer risk factors, enabling us to extend life-saving lung cancer screening to all who are at risk. Dr. Nate Pennell: I think that that would certainly be welcome. And as AI is working its way into pretty much every aspect of life, including medical care, I think it's certainly promising that it can improve on our existing technology.  We don't have to spend a lot of time on this because I know it's a little out of scope for what you covered in your paper, but I'm sure our listeners are curious about your thoughts on the use of other types of testing beyond CT screening for detecting lung cancer. I know that there are a number of investigational and even commercially available blood tests, for example, for detection of lung cancer, or even the so-called multi-cancer detection blood tests that are now being offered, although not necessarily being covered by insurance, for multiple types of cancer, but lung cancer being a common cancer is included in that. So, what do you think? Dr. Cheryl Czerlanis: Yes, like you mentioned, there are novel bioassays such as blood-based biomarker testing that evaluate for DNA, RNA, and circulating tumor cells that are both promising and under active investigation for lung cancer and multi-cancer detection. We know that such biomarker assays may be useful in both identifying lung cancers but also in identifying patients with a high-risk result who should undergo lung cancer screening by conventional methods. Dr. Nate Pennell: Anything that will improve on our rate of screening, I think, will be welcome. I think probably in the future, it will be some combination of better risk prediction and better interpretation of screening results, whether those be imaging or some combination of imaging and biomarkers, breath-based, blood-based. There's so much going on that it is pretty exciting, but we're still going to have to overcome the stigma and lack of public support for lung cancer screening if we're going to move the needle. Dr. Cheryl Czerlanis: Yes, I think moving the needle is so important because we know lung cancer is still a very morbid disease, and our ability to cure patients is not where we would like it to be. But I do believe there's hope. There are a lot of motivated individuals and groups who are passionate about lung cancer screening, like myself and my co-authors, and we're just happy to be able to share some ways that we can overcome the challenges and really try and make an impact in the lives of our patients. Dr. Nate Pennell: Well, thank you, Dr. Czerlanis, for joining me on the By the Book Podcast today and for all of your work to advance care for patients with lung cancer. Dr. Cheryl Czerlanis: Thank you, Dr. Pennell. It's such a pleasure to be with you today. Thank you. Dr. Nate Pennell: And thank you to our listeners for joining us today. You'll find a link to Dr. Czerlanis' article in the transcript of this episode.  Please join us again next month for By the Book's next episode and more insightful views on topics you'll be hearing at the education sessions from ASCO meetings throughout the year, and our deep dives on approaches that are shaping modern oncology. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Follow today's speakers:     Dr. Nathan Pennell    @n8pennell   @n8pennell.bsky.social Dr. Cheryl Czerlanis Follow ASCO on social media:     @ASCO on X (formerly Twitter)     ASCO on Bluesky    ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Nate Pennell:        Consulting or Advisory Role: AstraZeneca, Lilly, Cota Healthcare, Merck, Bristol-Myers Squibb, Genentech, Amgen, G1 Therapeutics, Pfizer, Boehringer Ingelheim, Viosera, Xencor, Mirati Therapeutics, Janssen Oncology, Sanofi/Regeneron       Research Funding (Institution): Genentech, AstraZeneca, Merck, Loxo, Altor BioScience, Spectrum Pharmaceuticals, Bristol-Myers Squibb, Jounce Therapeutics, Mirati Therapeutics, Heat Biologics, WindMIL, Sanofi    Dr. Cheryl Czerlanis: Research Funding (Institution): LungLife AI, AstraZeneca, Summit Therapeutics

This episode is with a good friend and collaborator, Dr. Marco Meucci of COSMED. Marco was formally an Associate Professor in the Public Health and Exercise Science Department at Appalachian State University, where he also served as the Director of their wellness and human performance lab. He now is the Academics Manager for COSMED, an Italian company that “designs, manufactures, and sells worldwide diagnostic medical devices to assess Lung function, Metabolic, and Body Composition.” Marco shares his story and progression as an athlete, student, professor, and leader in academia. We discuss how he made decisions leading to where he is today and how he uses the sparks to create forks in life, then takes the most exciting one. We believe you are going to love the energy and insight this enthusiastic Italian brings to the show. Enjoy!

Join me live every Monday at 8 PM EST, and let's crush those NCLEX goals together. Be part of a supportive community that's dedicated to your success. Sign up today at ReMarNurse.com/RNU and get your free workbook to keep you on track: https://bit.ly/RNU2025. This is your moment—see you in class!   Join Prof. Regina Callion, MSN RN the #1 instructor on the planet as she provides an insightful overview of lung sounds—what they mean, how to assess them, and their importance in nursing practice. Learn nursing priorities and key considerations to enhance patient care. Perfect for nursing students and professionals aiming to deepen their understanding of respiratory assessment! Don't forget to like, comment, and subscribe for more informative content on nursing and healthcare topics.   Download the ReMar V2 App: ►For iOS: https://apps.apple.com/us/app/remar-v2/id6468063785 ►For Android: https://play.google.com/store/apps/details... ► Find JOBS: http://ReMarNurse.com/jobs ► NCLEX for Africa - http://ReMarNurse.com/KENYA ► Get NCLEX V2: http://www.ReMarNurse.com ►NCLEX V2 Free Trial - http://ReMarNurse.com/free ► FOLLOW ReMar on Instagram: https://www.instagram.com/ReMarNurse/ ► LIKE ReMar on Facebook: https://www.facebook.com/ReMarReview/ ► Subscribe Now on YouTube - http://bit.ly/ReMar-Subscription  

Episode Summary McKenzie and Io chin wag about Conclave, the two popes and Catholicism and make a case for why Conclave should be ushered in gay film canon (a buncha messy flamboyant divas in iconic outfits backstab each other and treat women weirdly to see which of their boys gets to be the man?) What's better than this? Guys being dudes. Host Info Io can be found on Twitter @Bum_lung or on Instagram @Bum.Lung or you can find shirts and patches that they make on Etsy at https://www.etsy.com/shop/BumLung Publisher This show is published by Strangers in A Tangled Wilderness. We can be found at www.tangledwilderness.org, or on Twitter @TangledWild and Instagram @Tangled_Wilderness. You can support the show on Patreon at www.patreon.com/strangersinatangledwilderness. Our logo is by Robin Savage. And our theme music is by a lovely mountain goblin.

Wet or dry. Air in or out. Reactive or obstructive. The possibilities may seem endless when treating the pediatric patient with undifferentiated respiratory distress. It is confounded by the fact that pediatrics are outside the comfort zone of many novice critical care transport providers. In this podcast episode, neonatal/pediatric specialist Nate Brown eases your worries with concise and effective means of diagnostics and intervention. Primarily, we cover croup, bronchiolitis, and asthma disease processes. Get CE hours for our podcast episodes HERE! -------------------------------------------- Twitter @heavyhelmet Facebook @heavyliesthehelmet Instagram @heavyliesthehelmet Website heavyliesthehelmet.com Email contact@heavyliesthehelmet.com Disclaimer: Heavy Lies the Helmet's content is for educational purposes only and does not constitute medical advice. Always follow local guidelines and consult qualified professionals before applying any information. The hosts and guests are not responsible for errors, omissions, or outcomes. Views expressed are their own and do not reflect their employers or affiliates. --------------------------------------------  Crystals VIP by From The Dust | https://soundcloud.com/ftdmusic Music promoted by https://www.free-stock-music.com