Podcasts about Excitation

In this video, I'll be sharing the most effective way I've found to work with perimenopausal symptoms using herbs and understanding your unique energetic constitution or tissue state. As a clinical herbalist, I believe that finding the right match can make all the difference. I'll introduce you to American Ginseng (Panax quinquefolius)—an herb every woman entering perimenopause should consider for overall vitality, along with specific dosing tips. Plus, I'll dive into the four most common tissue states that often get out of balance during this stage: Excitation, Depression, Tension, and Atrophy. I'll guide you through how to identify these states in your body and share the best herbs to help restore balance, with dosing recommendations for each. I'll also cover commonly used herbs like Black Cohosh, Hops, and Dong Quai, explaining which specific patterns they work best with and how they can support your journey through perimenopause. I keep things lighthearted and easy to understand, so you can quickly discover the herbs that will help you feel more at ease and vibrant through this transition. Product Links: Herb for All Women - American Ginseng - Panax quinquefolius - https://mountainroseherbs.com/american-ginseng-extract For Hot/Excitation Types  Milky Oat Tops Tincture - https://amzn.to/4fjafJZ  Hops Tincture - https://amzn.to/48gRhkT  Hops Capsules - https://amzn.to/3YBhNC8 For Cold/Depressed Types  Angelica (archangelica - American or sinensis - Chinese) - https://mountainroseherbs.com/angelica-extract and https://amzn.to/3Yz4dix  Black Cohosh - https://www.herbalist-alchemist.com/shop-products-bck-black-cohosh-extract For Tension Types  Blue Vervain - Verbena hastata - https://www.herbalist-alchemist.com/shop-products-bvv-blue-vervain-extract  Hops Tincture - https://amzn.to/48gRhkT For Dry/Atrophy Types  Shatavari (Asparagus racemosus) - https://mountainroseherbs.com/shatavari  Marshmallow Root - https://mountainroseherbs.com/marshmallow-root

Check out our recap and breakdown of Season 3 Episode 23 of the Big Bang Theory! We found 5 IQ Points!00:00:00 - Intro00:12:52 - Summary Begins00:14:33 - What is Lunar Ranging? 00:40:08 - Graphic Design is Science!00:53:13 - That wasn't in Frankenstein! 01:05:11 - Penicillin, life's greatest mistake01:38:25 - Did Leonard do the math right? Find us everywhere at: https://linktr.ee/theoreticalnonsense~~*CLICK THE LINK TO SEE OUR IQ POINT HISTORY TOO! *~~-------------------------------------------------Welcome to Theoretical Nonsense! If you're looking for a Big Bang Theory rewatch podcast blended with How Stuff Works, this is the podcast for you!  Hang out with Rob and Ryan where they watch each episode of The Big Bang Theory and break it down scene by scene, and fact by fact, and no spoilers! Ever wonder if the random information Sheldon says is true? We do the research and find out! Is curry a natural laxative, what's the story behind going postal, are fish night lights real? Watch the show with us every other week and join in on the discussion! Email us at theoreticalnonsensepod@gmail.com and we'll read your letter to us on the show! Even if it's bad! :) Music by Alex Grohl. Find official podcast on Apple and Spotify https://podcasts.apple.com/us/podcast/theoretical-nonsense-the-big-bang-theory-watch-a/id1623079414

C'est le quatrième et le dernier monument trail de l'année. Dans quelques jours, la 32ème édition de la Diagonale Des Fous va débuter. Cette épreuve, considérée comme l'une des plus compliquées au monde est même rallongée pour 2024. De quoi rendre cette course encore plus mythique, elle qui compte plus de 10.000 mètres de dénivelé positif et 175 kilomètres à parcourir ? Pour évoquer cette traversée de l'île de la Réunion, Benoît Boutron et Yohan Durand reçoivent le dernier vainqueur de la Diagonale Des Fous, Aurélien Dunand-Pallaz ! Avec lui, ils reviennent sur son état de forme, lui qui a récemment abandonné lors de l'UTMB. Comment se sent-il physiquement et mentalement ? Pourquoi a-t-il décidé de partir 5 semaines à la Réunion ? Et pourquoi cette course est tout simplement sa préférée ? Grâce à ce champion bienveillant, vous aurez également tous les bons conseils pour appréhender au mieux la Diagonale des Fous : conditions météo, équipements à prévoir, ravitaillements, dangerosité des chemins, allures à respecter : vous saurez tout ! La séance de la semaine, elle sera consacrée au retour d'un mythe : la montée du Maïdo et les 1800 mètres de dénivelé positif... pratiquement non-stop ! Comment doit-on appréhender une telle difficulté ? Et quelles sont les clés essentielles pour ne pas trop souffrir ?Et enfin, dans le bon plan matos, RMC Running vous permet de remporter trois tee-shirts ADN de la marque Sensus, la gamme running éco-responsable qui propose des vêtements encore plus légers et écologiques !

Après plus d'un mois sans donner de nouvelle sur le podcast, je suis enfin prête avec mes nouveautés.Je te fait un bilan sur comment s'est passée ma pause, entre péripéties et annonces :)J'avais besoin de parler avec toi avant de poster le premier épisode de Dimanche, en espérant que ton été s'est bien passé.Bande annonce officielle :Sur instagram : https://www.instagram.com/reel/C_qZTbcsClA/?igsh=OGhqbHY3bWE3bGdkSur tiktok : https://vm.tiktok.com/ZGeKxJnEf/(j'ai oublié de préciser je l'ai tourné entièrement à Copenhague

In this episode, we explore Autism developing in the embryo. We will review a couple Scientific papers discussing specific time frames of development within the embryo based on each trimester and specific cellular abnormal processes occurring. We will connect previous biological and environmental components and how it influences the creation of Autism and previous episodes of From the Spectrum podcast.Remember in the Cause of Autism episode- Light, Water, Magnetism, Periodic Elements, Vitamins, and Proteins because they are involved. During the episode, we review risk-genes and how this could be the wrong direction for Autism research. As a counter, I provide where research and funding needs to focus- pregnancy.Cause of Autism https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496Eric Courchesne https://profiles.ucsd.edu/eric.courchesnePrenatal Origins of ASD: The When, What, and How of ASD Development https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223620300515%3Fshowall%3DtrueThe ASD Living Biology: from cell proliferation to clinical phenotype https://www.nature.com/articles/s41380-018-0056-yLeukocytes and Melanin Pigmentation https://core.ac.uk/download/pdf/81931995.pdfmTOR and PTEN https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/Cancer Drug for "Autism" https://neurosciencenews.com/asd-cognition-cancer-pharmacology-26481/0:00 Autism and the Embryo; Review of previous developmental milestones, and the processes and "ingredients" used in our Biology5:45 Cellular processes; ASD Living Biology; becoming the complex living organism8:17 1st Trimester: Proliferation, neurogenesis, migration8:46 2nd Trimester: Neurite overgrowth, synaptogenesis and synaptic function9:12 3rd Trimester: Neural networks9:33 Epoch 1 and 213:04 Scientific Literature; risk-genes; send research and funding to pregnancy17:57 Abnormal brain development in the embryo21:39 Excitation and the risk-genes and consequences to the Nervous System24:36 Be cautious of research direction; MEDICATION and MEDICAL PARADIGM RANT29:32 Connecting Light and Abnormal Development across the Body- Example Melanin and Leukocytes33:12 Recap on the Past 3 episodes36:00 Reviews/Ratings and Contact InfoX: https://twitter.com/rps47586Facebook: https://www.facebook.com/fromthespectrum.podcastEmail: info.fromthespectrum@gmail.com

RMC Running est heureux de vous proposer plusieurs épisodes consacrés à la course de trail running la plus mythique et la plus prestigieuse au monde : 171 km et 10 000 mètres de dénivelé positif pour faire le tour du Mont-Blanc ! Désormais appelé HOKA UTMB Mont-Blanc, cette épreuve traverse l'Italie, la Suisse et la France. L'objectif de ces podcasts est simple : suivre la préparation de ces athlètes, professionnels comme amateurs, qui vont s'engager sur cette traversée iconique, mondialement reconnue, et qui s'élancera le 30 août prochain. Cette semaine, Benoît Boutron et Yohan Durand reçoivent Mahauld Becker-Granier et Julia Harnie afin de faire le point sur leurs entraînements respectifs. Entre week-ends chocs, dénivelé positif et séance de renforcement musculaire, ces deux championnes se préparent pour l'évènement de l'année en trail. Le stress existe-t-il ? Sont-elles à 100% physiquement et mentalement ? Vous saurez tout !

Girls night!Our episode discussion this week includes Indiana Jones, the submarine controversy, Eat Pray Love, siding with Sheldon, slumber parties, finally getting in Penny's head, and more!Below are the two screenshots mentioned that Nicole sent Roxanne while recordingDownload hereRunning time: 1:11:44, 43.2 MB

3 Actions that Mark Your Commitment to Christ's Church--1 - Faith's Exaltation -8--2 - Faction's Eradication -9-11--3 - Friend's Excitation -12-15-

3 Actions that Mark Your Commitment to Christ's Church--1 - Faith's Exaltation -8--2 - Faction's Eradication -9-11--3 - Friend's Excitation -12-15-

3 Actions that Mark Your Commitment to Christ's Church1 - Faith's Exaltation (8)2 - Faction's Eradication (9-11)3 - Friend's Excitation (12-15)

La 85e édition du Bol d'Or Mirabaud se court le 15 juin prochain. Une édition marquée par plusieurs nouveautés, dont un village au Port-Noir ou encore trois catégories de course. Yann Petremand, le président du comité d'organisation du Bol d'OR Mirabeau, était invité de Béatrice Rul, à 7h30, sur Radio Lac. Une semaine tout pile avant le départ de la 85e édition du Bol d'Or Mirabeau. C'est un mélange d'excitation et d'anxiété: "Excitation oui, car on se réjouit, chaque année, que cette régate prenne son départ, dans la rade, avec tous ces concurrents présents à ce rendez-vous de la voile internationale. Pas d'anxiété car nous travaillons, depuis des mois, avec l'organisation pour que le déroulement de cette course se passe dans les meilleures conditions, tant sur l'eau qu'à terre. Nous sommes donc plutôt sereins".La grande question c'est… à quelle heure la course va-t-elle se terminer? Ces derniers années, toujours très tard. Pas avant 23h.. avec un quasi 3 heures du matin, l'année dernière… "Nous ne maîtrisons pas la météo et on espère de notre côté, cette année. Les deux dernières éditions, on n'a manqué de vent. C'est une autre difficulté pour les concurrents, ça fait partie de ce sport".La grande différence, cette année, c'est ce Village Bol d'Or Mirabeau, au Port Noir, plutôt que d'être à la Nautique. Volonté d'en faire un vrai événement populaire, à Genève…"On 'a pas abandonné la Nautique, ce site est complémentaire du village. C'est là que seront tous les bateaux des concurrents et que se fera toute la coordination de ce qui se passe, sur l'eau. Il y a une volonté de la Société Nautique de Genève de s'ouvrir à un public plus large, de démocratiser ce sport qui paraît trop souvent élitiste"

Parfois on vit des périodes trop cools, puis parfois beaucoup moins cools. C'est ce qu'on appelle tout simplement la vie. Puis aujourd'hui j'avais envie de transposer ça au business . Quand vous êtes en business, vous voulez naturellement que ça roule tout seul. On s'imagine toutes que c'est exactement ce qui va se passer au début de l'aventure. Excitation à fond, on a hâte …. Puis on commence à rencontrer des choses . Et comme on avait pas mis ça dans l'équation, c'est comme une douche froide. On le vit mal parce qu'avec tout ce qu'on avait mis en place ça vient pas comme c'était prévu. Et ces moments là on les prend mal. Du moins on les interprète mal. Et on les vit mal. Alors aujourd'hui je voudrais que vous partiez de cet épisode avec une autre vision. Et si ce que vous vivez était le chemin de votre succès?Vous appréciez? Merci de laisser ⭐⭐⭐⭐⭐ 5 étoiles sur le podcast, vous lui permettez d'être plus écouté et de servir de plus en plus d'entrepreneuses chaque semaine!RESSOURCES :Pensez à télécharger les 33 principes PREMIUM pour manifester votre business à succès : https://elodieflorenti2.systeme.io/33principesMe rejoindre sur:

In Part 2 of the Excitation and Inhibition phenomena, we discuss Metabolic "bank" account and demands of navigating the social world. We discuss if we have enough resources or if we will run a metabolic deficits (think burnout and avoidance, and social isolation). We cover NMDA and AMPA and different Autistic Phenotypes. In addition, we review Neuromodulators, which are vast in our biology and determine how and where to direct our attention and energy. Lastly, we discuss the medial Prefrontal Cortex and how it integrates the "self" with the outside world.Don't try to change an Autistic person because they are different than you or different than others. Don't let that offend your beliefs and capacity to apply critical thinking in life.https://www.nature.com/articles/s41398-023-02317-5https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723386/https://www.nature.com/articles/s41398-018-0155-1https://www.nature.com/articles/nature10360https://onlinelibrary.wiley.com/doi/full/10.1034/j.1601-183X.2003.00037.x?sid=nlm%3Apubmedhttps://www.nature.com/articles/s41380-022-01506-w(0:00) Introduction; Know Autism and Make Informed Decisions; Biological Aspects influencing Excitation / Inhibition Phenomena(4:30) Metabolic "Bank" Account and Resources; E/I creates criteria A and B; NMDA and AMPA, and more on the Striatum(10:02) Neuromodulators- Serotonin, Dopamine, Epinephrine and Norepinephrine, Acetylcholine; Active versus Passive Coping; Activating Systems and Cells and influencing Learning and Memory (Neuroplasticity); Nicotinic Receptors and Rapid-Excitation(15:20) medial Prefrontal Cortex (mPFC)- Metabolic demands and planning while considering Feelings, Integrating the Self and the Outside World; How E/I interacts; a brief explanation on Default Mode Network; Quieting the Body, or not; Information-Processing; Thalamocortical(20:19) Pursuits and Preference- Wanting and Having and being Autistic is fine, and others need to accept our phenotypes; sensory-input causes Faster Firing Rates in normal E/I- Image an imbalanced E/I(22:25) Wrap-up and understanding Autism, and Contact Info

En collaboration avec l'UTMB, RMC Running est heureux de vous proposer plusieurs épisodes consacrés à la course de trail running la plus mythique et la plus prestigieuse au monde : 171 km et 10 000 mètres de dénivelé positif pour faire le tour du Mont-Blanc en traversant l'Italie, la Suisse et la France. L'objectif ? Suivre la préparation de ces athlètes, professionnels comme amateurs, qui vont s'engager sur cette épreuve iconique, mondialement reconnue, et qui s'élancera le 30 août prochain. Cette semaine, Benoît Boutron reçoit trois personnalités féminines bien différentes, mais avec un objectif commun : le plaisir de courir en montagne. Maryline Nakache, lauréate de la TDS l'an dernier et du Marathon des Sables évoquera son nouveau mode de vie et ses ambitions futures. Récente huitième de la Diagonale des Fous, Julia Harnie expliquera sa préparation, elle, qui est également coach sportive ! Mahauld Becker-Granier, journaliste pour RMC, passionnée de trail, se confiera sur son impatience, mais également son stress de découvrir cette course si mythique de l'UTMB.Et enfin, Stanislas Gruau viendra nous donner de ses nouvelles, lui, qui a bouclé le Marathon de Paris il y a quelques jours !

In this episode, we discuss the Excitation and Inhibition Phenomena in Autism. There are many biological aspects implicating the E/I balance, and the Nervous System needs a healthy balance. This episode extends slightly downstream of the Genetic and Protein implications previously discussed. We discuss cortical and subcortical areas, sensations, introduce Glutamate and GABA, and discuss the critical period. The critical period is, pardon the pun, a critical period for Autism. In addition, we discuss BDNF and introduce neuroplasticity. Finally, we discuss Melanin and Melanopsin and sunlight and modern light, and the vast implications from our new environment. To end, we connect many modern diseases to these biological factors.See Dr. Jack Kruse Quantum Engineering 45Email: info.fromthespectrum@gmail.com

In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary. Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdfPTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue16p11.2, Serotonin, and Possible Social Deficit Rescueshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/https://www.nature.com/articles/s41586-018-0416-4https://www.nature.com/articles/s41386-021-01091-6https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/https://www.sciencedirect.com/science/article/pii/S0092867414006734(0:00) Introduction; Excitation and Inhibition; (3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should? (10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;(19:24) Back to 16p11.2 and Cortical Development;(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC(29:25) Wrap Up and Contact Informationemail: info.fromthespectrum@gmail.com

J-5. Ce dimanche 7 avril, plus de 60.000 coureurs vont arpenter les rues de la capitale à l'occasion du Marathon de Paris. Un soulagement pour la plupart d'entre eux avec l'aboutissement de trois mois de préparation. Parmi eux, les 4 heureux élus sélectionnés par RMC Running, à savoir les deux Camille, Benoit et Antoine. Comment se sentent-ils à quelques jours de l'évènement ? Physiquement et mentalement, sont-ils à 100% ? Malgré l'excitation, le stress peut-il faire son apparition ? Alimentation, hydratation, tenues vestimentaires : les derniers réglages sont-ils finalisés ? Ils disent tout à Benoît Boutron et Yohan Durand dans cet épisode hors-série consacré à la plus grande course de France ! Et enfin, Benoît Boutron et Yohan Durand vous donnent rendez-vous à deux reprises ce vendredi 5 avril. Vous pouvez venir assister à une conférence à 14h00 au salon du running ou bien venir rencontrer l'équipe le vendredi soir dans les rues de Paris grâce à Asics !

Jour 5 du calendrier X-MAS: les réactions sexuelles de Masters et Johnson Les pionniers de la sexologie ont proposés un modèles sur les réactions sexuelles humaines lors des rapports sexuels. Un modèle qui à permis d'avancer dans les recherches sur la sexualité.  Mais pouvons-nous encore développer ce modèle ? Qui a-t-il à chercher ? Moi j'ai ma petite idée ! On ne sait pas ce que ce mois nous réserve... à demain !Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

In this episode, my guest is Robert Greene, multiple New York Times bestselling author and expert on human psychology and behavior both at the individual and group levels and in the context of relationships, careers, and society. We discuss how to find, pursue and achieve one's unique life purpose, and how to best learn from good and hard experiences along that journey. We discuss power dynamics in relationships, the different types of human communication and the interplay between seduction and vulnerability. We discuss how to find the right romantic partner, improve healthy self-awareness, the link between anxiety and creativity, and pick ideal mentors and role models. Robert also discusses his recent stroke and what he has learned from his near-death experience about motivation, urgency and appreciation for life. Listeners of all ages will benefit from Robert's insights on navigating the process of building a deeply purposeful life and enhancing one's relationship with the self, others and society.  For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Helix Sleep: https://helixsleep.com/huberman Waking Up: https://wakingup.com/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://www.livemomentous.com/huberman Timestamps (00:00:00) Robert Greene (00:01:58) Sponsors: ROKA, Helix Sleep & Waking Up (00:05:56) Mastery (The Book), Purpose (00:08:26) Finding Purpose, Childhood, Learning & Emotional Engagement (00:18:00) Early Interests, Delight & Discovery (00:22:50) Love vs. Hate Experiences & Learning (00:28:25) Self-Awareness, Frustration, Excitation (00:31:47) Sponsor: AG1 (00:33:18) Sublime Experiences, Real vs. False; Authenticity & Time (00:43:57) Power & Relationships; Purpose & Mastery (00:55:51) Seduction, Vulnerability, Childhood (01:07:04) Sponsor: InsideTracker (01:08:05) Power Dynamics & Romance; Equality, Love Sublime & Connection (01:18:42) Vulnerability in Relationships, Creativity; Social Media, Justice (01:29:45) Outrage, Control, “Art of Ignore” (01:33:50) Masculinity & Femininity (01:42:16) Picking Role Models; Purpose & Mentor Relationship (01:51:07) “Alive” Thinking; Anxiety & Creativity (01:58:55) Convergent Interests & Romantic Relationships (02:07:19) Self-Awareness, Core Values & Romantic Relationships (02:15:27) Non-Verbal Communication & Relationships (02:24:58) Eyes, Voice, Intuition & Seduction (02:28:38) Virtual World, Social Skills, Non-Verbal Communication (02:32:19) Self-Awareness & Intelligence, Artificial Intelligence (AI), Nuance (02:41:43) Human Brain, Plasticity (02:45:18) Stroke & Near-Death Experiences, Self, Time (02:55:49) Appreciation & Near-Death Experience, Urgency (03:01:36) “Death Ground” & Urgency (03:09:13) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

Introducing Zack and Amy! (0 Z, and 0 A)We kick things off with a bit of general TV discussion, including British TV, streaming vs network, and waiting years for new episodesOur episode discussion includes lots of gushing about Zack, Leonard and Penny being a mess on different pages, excitement over introducing Amy, and more!The TikTok Nicole talks about can be watched hereOur recording may continue to be sporadic for a bit, but watch for updates on twitter!Download hereRunning time: 1:06:30, 40 MB

Let's set off on an awe-inspiring journey with our guest, Cecilia Martinez, who, armed with self-awareness and an appetite for growth, has carved out a successful career in software development. Starting from her high school days, designing layouts for myspace pages, Cecilia's trajectory includes journalism, web development, and a self-discovery of her place in tech communities. Her story of growth and transformation, nurtured by her battles with ADHD, the trials and triumphs of a software development boot camp, and her blossoming career as a community lead at Replay, is nothing short of inspiring.What role can tech communities play in launching and shaping your career? Listen as Cecilia shares her experience exploring various local tech groups and the profound impact they had on her career. We examine the role of multi-channel outreach in creating diverse and representative communities and discuss how these communities can act as springboards for newcomers to the industry. Cecilia's narrative underlines the importance of aligning work with passion, the power of self-awareness, and the necessity to take calculated risks.From being a people pleaser to learning to push back when necessary, Cecilia shares the invaluable lessons she's picked up navigating her career paths. We discuss the decision-making processes involved in considering the next career move, the advantages of early-stage startups, and how she's grown to identify the most valuable work to do with her time. Cecilia also shares insights from her deep involvement with open source development tools and the influence these experiences have had on her career. Join us as she takes us through her journey of discovery and growth in the tech space.Use my special link https://zen.ai/dsVpYxjSth5fD-hlbzdIiw to save 30% off your first month of any Zencastr paidplan.Support the show

Dans cet épisode envoûtant des Fantasmes de Suzy, Suzy nous transporte dans une aventure sensuelle et Rock 'n' Roll. Suivez Suzy dans cette histoire captivante de désir brûlant, de rencontre et de découverte de soi. Entre musique enivrante et étreintes passionnées, cet épisode explore l'excitation de l'inconnu et le pouvoir de l'attraction.

Colloque de rentrée 2023 - Apprendre et enseigner, de la préhistoire à demainExcitation/Inhibition, le bon équilibre pour apprendre et réapprendreIntervenant(s)Alain Prochiantz, Professeur du Collège de France, Administrateur du Collège de France (2015 à 2019)Séance animée par Stanislas Dehaene.Chaque communication de 30' sera suivie de 10' de discussion.RésuméAu cours du développement postnatal, les différentes régions du cortex cérébral doivent s'adapter au monde dans ses multiples composantes. Ces apprentissages, non synchrones mais limités dans le temps, sont médiés par des signaux sensoriels, moteurs, affectifs ou sociaux. Ces signaux initient la maturation d'un circuit d'apprentissage, relativement simple et conservé dans l'entièreté du cortex, fondé sur l'évolution de la balance ente inhibition excitation au sein de ce circuit. Chez l'adulte si la capacité d'apprendre est perdue ou diminuée le cortex peut garder pour la vie des séquelles plus ou moins heureuses de son « aventure développementale ». D'où l'intérêt de moduler transitoirement, chez l'adulte, l'équilibre Excitation/Inhibition afin de rouvrir une période de plasticité favorable à des apprentissages nouveaux ou à la correction d'apprentissages « malheureux ».

You never know what might happen when Rock & Roll Hall of Famer Mike Love pops into your tasting room.  For Seven Caves it was the beginning of an epic collaboration of spirts and flavors starting with today's beverage, Excitation.

Des peines à rabais pour éviter les arrêts de procédures. Il laisse un message vocal en direct pendant qu'il assassine un octogénaire. Excitation et maladie autour du retour d'Éric Lapointe. Discussion Crime et Société avec Félix Séguin, journaliste au Bureau d'enquête de Québecor.Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

Chronique d'Anne-Marie Ménard, professionnelle en sexologie.Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.19.549778v1?rss=1 Authors: Gemperli, K., Lu, X., Chintalapati, K., Rust, A., Bajpai, R., Suh, N., Blackburn, J., Gelineau-Morel, R., Kruer, M. C., Mingbunjerdsuk, D., O'Malley, J., Tochen, L., Waugh, J., Wu, S., Feyma, T., Perlmutter, J., Mennerick, S., McCall, J. G., Aravamuthan, B. R. Abstract: Dystonia is common, debilitating, often medically refractory, and difficult to diagnose. The gold standard for both clinical and mouse model dystonia evaluation is subjective assessment, ideally by expert consensus. However, this subjectivity makes translational quantification of clinically-relevant dystonia metrics across species nearly impossible. Many mouse models of genetic dystonias display abnormal striatal cholinergic interneuron excitation, but few display subjectively dystonic features. Therefore, whether striatal cholinergic interneuron pathology causes dystonia remains unknown. To address these critical limitations, we first demonstrate that objectively quantifiable leg adduction variability correlates with leg dystonia severity in people. We then show that chemogenetic excitation of striatal cholinergic interneurons in mice causes comparable leg adduction variability in mice. This clinically-relevant dystonic behavior in mice does not occur with acute excitation, but rather develops after 14 days of ongoing striatal cholinergic interneuron excitation. This requirement for prolonged excitation recapitulates the clinically observed phenomena of a delay between an inciting brain injury and subsequent dystonia manifestation and demonstrates a causative link between chronic striatal cholinergic interneuron excitation and clinically-relevant dystonic behavior in mice. Therefore, these results support targeting striatal ChIs for dystonia drug development and suggests early treatment in the window following injury but prior to dystonia onset. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.13.547220v1?rss=1 Authors: Arias-Hervert, E. R., Birdsong, W. T. Abstract: Activation of opioid receptors in the anterior cingulate cortex (ACC) mediates aspects of analgesia induced by both exogenous and endogenous opioids. We have previously shown that opioids signaling disrupts both afferent excitatory and indirect inhibitory synaptic transmission from the medial thalamus (MThal) to the ACC, but the effects of endogenous opioids within this circuit remain poorly understood. The goal of the current study was to understand how the endogenous opioid, [Met]5-enkephalin (ME), modulates thalamic-driven excitatory and inhibitory synaptic transmission onto layer V pyramidal neurons in the ACC. We used pharmacology, brain slice electrophysiology and optogenetic stimulation to study opioid-mediated modulation of optically evoked glutamatergic and GABAergic transmission. The results revealed that ME inhibited both AMPA-mediated excitatory and GABA-mediated inhibitory synaptic transmission in the ACC. However, inhibitory transmission was more potently inhibited than excitatory transmission by ME. This preferential reduction in GABAA-mediated synaptic transmission was primarily due to the activation of delta opioid receptors by ME and resulted in a net disinhibition of MThal-ACC excitatory pathway. These results suggest that moderate concentrations of ME can lead to net excitation of ACC circuitry and that analgesia may be associated with disinhibition rather than inhibition of ACC subcircuits. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

J-5 avant le grand départ de l'Adidas 10K de Paris. Après avoir présenté Christelle et Christophe, les heureux élus du grand concours RMC Running et après avoir abordé les spécificités du parcours parisien, Benoît Boutron et Yohan Durand évoquent cette semaine l'appréhension des derniers jours. Sommeil, hydratation, étirements, dernières séances de running, tout sera détaillé. Le stress peut-il être positif ? L'excitation doit-elle monter progressivement ? Doit-on douter de sa forme physique ? Éléments de réponse dans ce troisième épisode hors-série consacré au plus grand 10km de France en plein cœur de la capitale.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.24.538166v1?rss=1 Authors: Zhu, J., Zikopoulos, B., Yazdanbakhsh, A. Abstract: Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Barbecue F1, le talk Formule 1 en mode barbecue de Radio Merguez and CoEmission du 21 mars 2023 - S03E03Avec Jacques Lafrite, Lance Niole, Niki Lambda, Takuma Sado et Sebastian Vittel en chair et en os ! Red Bull : seuls sur Mars tandis que les autres essayent d'aller sur la Lune Aston Martin : le météorite qu'on n'a pas vu venir Mercedes : le changement, c'est pas maintenant Ferrari : chi va piano va pa sano Les Frenchies : leaders du championnat de derrière Les 5 informations inutiles de la semaine de Sebastian Vittel Le prochain Grand Prix d'Australie et les fameux pronostics Le #BarbecueF1 est disponible sur toutes les plateformes (Spotify, Deezer, Apple, Podcast Addict, ...) après chaque grand prix le mercredi à partir de 6 heures. Au fait, si tu as des conseils et si tu veux participer à l'émission, n'hésite pas à nous contacter via Twitter, Facebook, Instagram, YouTube ;)

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.20.533519v1?rss=1 Authors: Kelley, C., Antic, S. D., Carnevale, N. T., Kubie, J. L., Lytton, W. Abstract: Rhythmic activity is ubiquitous in neural systems, and impedance analysis has been widely used to examine frequency-dependent responses of neuronal membranes to rhythmic inputs. Impedance analysis assumes the neuronal membrane is a linear system, requiring the use of small signals to stay in a near-linear regime. However, postsynaptic potentials are often large and trigger nonlinear mechanisms. We therefore augmented impedance analysis to evaluate membrane responses in this nonlinear domain, analyzing responses to injected current for subthreshold membrane voltage (Vmemb), suprathreshold spike-blocked Vmemb, and spiking in a validated neocortical pyramidal neuron computer model. Responses in these output regimes were asymmetrical, with different phase shifts during hyperpolarizing and depolarizing half-cycles. Suprathreshold chirp stimulation gave equivocal results due to nonstationarity of response, requiring us to use fixed-frequency sinusoids. Sinusoidal inputs produced phase retreat: action potentials occurred progressively later in cycles of the input stimulus, resulting from adaptation. Conversely, sinusoidal current with increasing amplitude over cycles produced a pattern of phase advance: action potentials occurred progressively earlier. Phase retreat was dependent on Ih and Iahp currents; phase advance was modulated by these currents. Our results suggest differential responses of cortical neurons depending on the frequency of oscillatory input in the delta -- beta range, which will play a role in neuronal responses to shifts in network state. We hypothesize that intrinsic cellular properties complement network properties and contribute to in vivo phase-shift phenomena such as phase precession, seen in place and grid cells, and phase roll, observed in non-place cells in hippocampus. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Épisode en deux parties... voilà la deuxème partie. Trouver l'amour lorsque l'on ne s'y attend pas, ça résume bien l'histoire de Colette. Son amour pour l'expatriation (malgré plusieurs échecs) mais aussi et surtout, son amour pour un Népalais !  Au départ, on va dire que Colette a un parcours classique. Elle fait ses études et évolue professionnellement en Île-de-France en allant d'une petite entreprise à une moyenne entreprise à une plus grande…Puis, 30 ans arrive. Elle a l'impression d'être au début de sa vie mais elle la trouve fade et elle pense qu'elle manque de saveur ! Pourtant, sur papier, cette vie semble parfaite. Mais elle va réussir à écouter sa boussole interne et ne pas se focaliser uniquement sur les apparences car elle souhaite être la meilleure version d'elle-même ! Elle commence par quitter son partenaire, qui, si elle se l'avoue, ne la fait pas vibrer même s'ils étaient en relation depuis 7 ans. Ensuite, c'est son emploi qu'elle va lâcher malgré le gros salaire qu'elle pouvait toucher. La voilà maintenant célibataire et au chômage ! Son état d'esprit à ce moment-là ? Excitation totale et fierté !  Elle va pouvoir se reconstruire en ouvrant le champ des possibles. Elle voit ce nouveau départ comme l'écriture d'une nouvelle aventure où elle va aller cocher des cases qu'elle n'aurait certainement même pas imaginer. Enfin… ce qu'elle aime surtout dire, c'est qu'elle ne va pas aller cocher des cases mais cocher à côté des cases car sa vision c'est :  “think outside de box” (pense en dehors des cases).  Elle va voyager et accepter des missions de freelance qu'elle n'avait pas vu venir. En y repensant, elle pense que l'univers était en train de la préparer pour la suite !  Puis à 37 ans, elle décide de partir avec deux copines pour une quête spirituelle, entre femmes, afin de prendre soin de son corps et de son esprit tout en découvrant une nouvelle culture.  Elle pensait qu'elle allait rencontrer beaucoup de personnes spirituelles mais finalement c'est l'amour qu'elle va rencontrer, 24h avant son vol retour pour la France ! Son mental occidental lui dit que ce n'est pas possible et pourtant, quand elle regarde Harry, elle se dit : “il a les yeux pleins d'étoiles et j'ai envie de nager dedans!”. Une histoire que l'on pourrait qualifier de conte de fée mais je ne vous en dis pas plus. Il vous suffit d'appuyer sur “lecture” pour découvrir cette belle histoire d'amour.  ---------------------------------------  

Épisode en deux parties... voilà la première partie. Trouver l'amour lorsque l'on ne s'y attend pas, ça résume bien l'histoire de Colette. Son amour pour l'expatriation (malgré plusieurs échecs) mais aussi et surtout, son amour pour un Népalais !  Au départ, on va dire que Colette a un parcours classique. Elle fait ses études et évolue professionnellement en Île-de-France en allant d'une petite entreprise à une moyenne entreprise à une plus grande…Puis, 30 ans arrive. Elle a l'impression d'être au début de sa vie mais elle la trouve fade et elle pense qu'elle manque de saveur ! Pourtant, sur papier, cette vie semble parfaite. Mais elle va réussir à écouter sa boussole interne et ne pas se focaliser uniquement sur les apparences car elle souhaite être la meilleure version d'elle-même ! Elle commence par quitter son partenaire, qui, si elle se l'avoue, ne la fait pas vibrer même s'ils étaient en relation depuis 7 ans. Ensuite, c'est son emploi qu'elle va lâcher malgré le gros salaire qu'elle pouvait toucher. La voilà maintenant célibataire et au chômage ! Son état d'esprit à ce moment-là ? Excitation totale et fierté !  Elle va pouvoir se reconstruire en ouvrant le champ des possibles. Elle voit ce nouveau départ comme l'écriture d'une nouvelle aventure où elle va aller cocher des cases qu'elle n'aurait certainement même pas imaginer. Enfin… ce qu'elle aime surtout dire, c'est qu'elle ne va pas aller cocher des cases mais cocher à côté des cases car sa vision c'est :  “think outside de box” (pense en dehors des cases).  Elle va voyager et accepter des missions de freelance qu'elle n'avait pas vu venir. En y repensant, elle pense que l'univers était en train de la préparer pour la suite !  Puis à 37 ans, elle décide de partir avec deux copines pour une quête spirituelle, entre femmes, afin de prendre soin de son corps et de son esprit tout en découvrant une nouvelle culture.  Elle pensait qu'elle allait rencontrer beaucoup de personnes spirituelles mais finalement c'est l'amour qu'elle va rencontrer, 24h avant son vol retour pour la France ! Son mental occidental lui dit que ce n'est pas possible et pourtant, quand elle regarde Harry, elle se dit : “il a les yeux pleins d'étoiles et j'ai envie de nager dedans!”. Une histoire que l'on pourrait qualifier de conte de fée mais je ne vous en dis pas plus. Il vous suffit d'appuyer sur “lecture” pour découvrir cette belle histoire d'amour.  ---------------------------------------  

Cette semaine, on prend le temps de discuter d'un sujet qui reste nébuleux malgré sa popularité dans les médias : le désir sexuel. On définit ce que c'est (selon la science) tout en apportant les différences et nuances des autres termes similaires : désir spontané, désir provoqué, excitation sexuelle, intimité sexuelle… Roxanne, sexologue thérapeute, nous aide à clarifier le tout et donne des exemples tirés de sa pratique clinique. On explore les causes ayant des impacts sur le désir pour terminer l'épisode avec quelques conseils et recommandations pour mieux vous outiller à comprendre le désir sexuel. Bonne écoute!Informations sur le coffret Sexo 100% plaisir:Interforum Canada : Diffuseur de plus de 250 maisons d'édition francophones.Pour découvrir le coffret : https://interforumcanada.com/livres/sexo-100-plaisir/ Suivez Interforum Canada sur les réseaux sociaux!Instagram : https://www.instagram.com/interforumcanada/Facebook : https://www.facebook.com/InterforumCanadaTikTok : https://www.tiktok.com/@interforumcanadaRéférences discutées dans l'épisode:Bancroft, J., & Janssen, E. (2000). The dual control model of male sexual response: A theoretical approach to centrally mediated erectile dysfunction. Neuroscience & Biobehavioral Reviews, 24(5), 571-579.Brotto , L. (2019). Better sex through mindfulness: How women can cultivate desire (2019). Greystone.Brotto, L., & Velten, J. (2020). Sexual Interest/Arousal Disorder in Women. In  K. S. K. Hall, and Y. M. Binik, Principles and practice of sex therapy (6th ed., pp. 13-40). Guilford Publications.Caswell, C. &  Schwenck, G. (2022). What's the best way to let your partner know you're not in the mood?Bachet, J. (2020). Charge mentale et baisse de libidoDubé, J (2022). Does how I respond to my partner's low desire matter? Esther Perel (2013). L'intelligence érotique : faire (re)vivre le désir dans le couple. Pocket.Excitation sexuelle ; Intimité  Godbout et al. (2022). Motifs de consultation 2021-2022 des personnes consultant en sexothérapie auprès de stagiaires en sexologie clinique. Document inédit.Les troubles du désir et de l'excitation chez la femme Loss of libido | NHS informMasters, W. H., & Johnson, V. E. (1966). Human sexual response. Little, Brown and Company.Nagoski, E. (2015). Come As You Are: The Surprising New Science that will Transform your Sex Life. Publisher: Simon and Schuster, 416p.Natacha Godbout | Trace Parish, S. J., & Hahn, S. R. (2016). Hypoactive sexual desire disorder: a review of epidemiology, biopsychology, diagnosis, and treatment. Sexual medicine reviews, 4(2), 103-120.Trouver votre sexologue - OPSQ

Today, we're going to talk about the 15 depression symptoms you may not know about. My hope is that it will help you, number one, understand your symptoms, and number two, get help faster. Let's do this. Let's get started.  I hope you are well. I hope you are kind and gentle to yourself today. I hope you are taking moments to notice that the trees are changing, the leaves are changing, and spring is here. If you're in the Northern Hemisphere, maybe the weather is changing. Also, if you're in the southern hemisphere, my lovely friends in Australia, I just want to remind you to stop and take note of the weather. It can be one of the most mindful activities we engage in, and it can help us be grounded in the present instead of thinking forward, thinking backward, and ruminating on the past and the future.  I hope you can take a minute. We can take a breath right here... and you can actually take in this present moment before we get started.  Today, we're talking about 15 depression symptoms you may not know about. As I said in the intro, my hope is that these symptoms help you understand what's going on for you if you're depressed or help you get help faster.  Mnemonic For Depression Symptoms Now, some of you may really have a good understanding of depression symptoms. Some of you may know the common ways that it shows up, so I will first address those just to make sure you've got a basic understanding of common depression symptoms. I'm going to actually give you a mnemonic for depression symptoms. I find it's very helpful to have this on hand when I'm assessing my clients and my patients. It's a really good check-in even for myself like, what's going on? Could this be depression? Let's go through this mnemonic for depression.  D is for depressed mood. I think we all know about that one. That's a very common Hollywood way of understanding people who are sad, feeling very down, and so forth. We mostly all know the D for depression.  E is for energy loss and fatigue. In fact, I did a poll on Instagram. For those of you who don't follow me, go ahead and follow me @youranxietytoolkit. I did a poll and I asked, what are the most painful parts of depression, and the most common response was complete fatigue, complete exhaustion, just overwhelming tiredness and energy loss. I think that that's a really common one. It can be confusing because you're like, “What's going on?” It makes you feel like maybe there's a medical condition going on, but often it is depression. The P is for pleasure loss. Now, this is an important one that we look for in clinical work as we're looking for. Is the person with depression completely at a loss and they're not enjoying the things they used to? Are they struggling to get joy out of even the most joyful things that they used to find joyful? That's a very common one.  The R is for retardation or excitation. What we're talking about there is moving very slowly, like a sloth pace or even just sitting there and staring and unable to move your body completely, inability to get motivated to move. Excitation is the other one, which is like you feel very jittery and you feel very on edge and so forth.  The E is for eating changes such as appetite increase or decrease, or weight increase or decrease. Again, common symptoms for depression.  The S is for sleep changes. It is very common for people with depression to either want to sleep or need to sleep all day, again, because of that energy loss. Or they lay awake for hours at night staring at the roof, unable to sleep, experiencing sleep anxiety, which can often then impact their sleep rhythm. They're sleeping all day, staying awake all night, or vice versa, but in a very lethargic way.  The next S is for suicidal thoughts or what we call suicidal ideation. These are thoughts of death, thoughts of dying, and sometimes plans to die. If that is you, please do go and see a mental health professional immediately or go to your ER or call the emergency in whatever country you are. For America, it's 911. Suicidal thoughts are very, very common with depression. We have two types of suicidal thoughts in depression, and that's usually passive suicidal thoughts and then active suicidal thoughts. Passive is thoughts of death, but you just want to crawl under a rock and just go to sleep and never wake up. Active suicidal thoughts is where you're actually wishing to die. It's important to differentiate, and clinically, we do make some changes depending on which is which.  The I for depression is “I am a failure.” This has a lot to do with shame or loss of confidence and self-esteem issues. “I am a failure” is a big one that often doesn't get disclosed until the person is in therapy. We even did an episode a couple of weeks ago. Depression Is A Liar was the title. Depression tells you all these lies. It tells you you're a failure and you start to believe it. It tells you there's something wrong with you and you start to believe it. That is a very common part of having depression.  The O is “only me to blame,” and this is what we call guilt. With depression, often people will feel guilty for everything, feel guilt & regret all day, every day. “I'm not a good mom,” “I'm not a good friend,” “I'm not a good talk daughter,” “I'm not a good employee,” “I'm not a good boss,” whatever it may be. And then they blame themselves, punish themselves, and a lot.  The N is for no concentration. Again, when I did the poll on Instagram, so many people posted that they just cannot think, they can't plan, they can't concentrate, they can't learn if they're in school, they can't stay focused on a conversation. These are all very common symptoms of depression that may be impacting you either a little bit or, in many cases, an immense amount. They're the most common. That's a mnemonic for depression symptoms. They're the most common that we assess for. But now I want to go into the 15 depression symptoms you may not know about.  The way that I'm structuring this podcast episode is I've broken it down into different categories of people. But what I want you to recognize before we go down is these are not specific to only these categories of people because it depends on the person. We have to be very person-centered when it comes to looking at depression and diagnosing depression and treating depression because there's no one way to have depression. I don't want to miscategorize any of this. I'm just talking very generally, so I want to give a disclaimer as I go through these different categories or groups of people. Please note that it's probably true for everybody. It's just more common in these groups.  Before we get started, I want to remind you. I know I did an announcement. I want to remind you, the Overcoming Depression Course is going live on March 11th. This is very exciting. This is a live online course that I am teaching live on Zoom. I will be teaching you over the course of three different weekends on Saturday mornings from 9:00 to 10:30 on March 11th, March 18th, and March 25th, 2023. If you want to sign up and come and learn from me, I'll be going through five major areas in which you can make changes related to depression. I will be giving you all of this psychoeducation upfront. There will be a workbook that you can use on your own to really put the skills and tools and strategies into place. If you're interested in joining us, may I say again live, head on over to CBTSchool.com/Depression. It'll take you to the page. You can sign up there and then I will send you via email all of the information you need to be there for our live conversations. You can ask questions in the chat box. My hope is to double down with motivating you, inspiring you, educating you, and getting you feeling a little more confident on what to do if you're struggling with these symptoms. My hope is to help you see that depression is a liar and you can break free!  Here we go.  Depression Symptoms In Men Again, I'm speaking generally here, and I really want to be careful here because it's definitely not just men who experienced this, but I did a lot of research for this episode and these were the statistics that I found to be most common in these areas.  Anger, irritability, or aggressiveness That's not in the mnemonic for depression that we went over. A lot of times people miss this core symptom, which is anger, irritability, or aggressiveness. Now, is it only men? Absolutely not. I want to be really clear here, that is absolutely not the case, but I think because of the stigma for men around showing sadness or showing depression, they have shown that men tend to express it in a different way, because sometimes men don't feel comfortable crying in public with their friends or loved ones. Not always true. Again, I'm going to keep saying not always, but I think that's a cultural expectation put on men and therefore it does come out when in the form of anger, irritability, or aggressiveness. Irritability is a huge one when it comes to depression that I have seen clinically.  Problems with sexual desire and performance This is, again, not just for men, but common in the research for men is common problems with sexual desire and performance. A lot of men and women, but again, I don't want to be excluding anyone here, have found that they either have a massive lack of sexual desire or struggle to reach arousal, struggle to reach orgasm. We are going to be addressing this in-depth here in the next couple of months and I'm going to put a lot of energy into making sure we address how much it impacts people and sex. Stick around for that. I'm super excited. But there is another common depression symptom you may not know about. Sometimes we think it's anxiety that causes that, but it's not just anxiety; it can be depression too.  Engaging in high-risk activities Again, not just for men, but it has been shown to be more prevalent in men. High-risk activities, spending a lot of money, driving fast in cars, gambling, drug use, and so forth. Again, not just in men, but this is another common depression symptom you may not know about and maybe diagnosed and put in a different category when really the person is deeply depressed and trying to feel pleasure. Remember we talked about the mnemonic P is for pleasure loss. Often we engage in these high-risk activities because we're just desperate to feel that sense of pleasure and exhilaration again.  A need for alcohol or drugs Again, not just men and I will discuss this in other categories as well, but it is common that an increased use of alcohol and drugs could be a sign that you are getting an increased level of depression. Then what happens is when you're using a lot of alcohol and drugs, you usually have a hangover or some kind of side effect to that which makes you feel more depressed, which then makes you feel more like you need to have more alcohol and drugs. Again, it's a cycle that can really cause a lot of chaos in people's life and could be simply the first symptom or way to cope with depression.  Depression Symptoms In Women Women are twice as likely to develop depression than men. That's a statistic I didn't know. Up to 1 in 4 women are likely to have major depressive disorder or major depression at some point in their life. 1 in 4, that is so high. We have to make sure we're catching people and helping people with this massive issue.  Premenstrual Dysphoric Disorder Prementstrual Dysphoric Disorder involves a massive influx of depressive symptoms right before your period or at specific stages of your menstrual cycle. Very common. In fact, again, we're going to be addressing this very soon on the podcast as well. These are some areas I feel like I have completely missed as your podcast host, so I want to really make sure we're targeting and addressing these issues as we move forward.  Perinatal Depression Perinatal depression occurs around pregnancy before or after pregnancy starts.  Perimenopausal Depression Perimenopausal depression is around the menopausal period for people going into menopause.  These are common symptoms of depression that get missed all the time or get misdiagnosed or underdiagnosed when the person is really suffering.  A lot of people who follow me have said they've gone to their doctor to share how they get this massive influx of depression before their period or in their cycle, and the doctor has blown them off and said, “Eat more celery juice,” or “Exercise more.” While, yes, exercising can be helpful for depression, we are missing a major depression symptom, and I want you to be informed about those. Depression Symptoms In Kids Oh, the kiddos. It's so hard on the kiddos. In fact, one of the reasons I have been so hyped on talking about depression was, in August of last year, my daughter went in for her yearly checkup with her pediatrician and the pediatrician insisted on doing all of these mental checklists with her. I was saying to her, “Is this really necessary? She's doing fine. To what degree are you scaring her?” She said, “Oh, you have no idea the degree of depression in children since COVID.” “I had no idea and I'm a mental health professional. How did I not know this?” She said, “Yeah, it's everywhere in kids, and kids are really good at hiding it.” I literally sank in my chair like, “How did I miss this? How did I not know this?” We talked about it a lot and I think it's really important that we understand that depression symptoms in kids often look like what we call in some societies like naughty kids. Again, let's go through them.  Big emotional outbursts  When we see kids on the playground having big outbursts, big anger responses, again, we talked about that before, sometimes they get labeled as the naughty kids. Well, guess what? We've got to make sure we check to make sure they're not depressed. Because that is a symptom of depression.  Difficulty initiating and maintaining social relationships Again, after COVID, a lot of parents I've heard have said, “Oh, I think they just lost their ability to make friends during COVID,” which I totally get. We had to train my son after COVID to follow basic social cues because he hadn't seen people in so long. But again, we have to keep an eye on whether this is a symptom of depression in children.  Extreme sensitivity to rejection or failure This one is so important not just for kids, but for teens, adults, everyone. With depression, we all have sensitivity to rejection of failure. No one wants that. But often a symptom of depression is extreme sensitivity and absolute devastation about getting rejected for, let's say, a school play or to be picked in soccer or they had a big issue with a test or so forth. They have a strong, strong reaction to that.  Frequent absences from school and/or a sudden decline in grades If kids got a massive decline in grades or they started refusing to go to school, my instinct is to always say, “Oh, there's some anxiety going on. They're anxious. They don't want to go to school, they must be ‘avoiding school' because of anxiety as a compulsion.” Well, guess what? It could be depression, and let's make sure we assess these kiddos correctly. This is true for adults as well. If we're depressed, we don't want to go out, we don't want to go to the show on Friday night, we don't want to hang out with friends. That makes sense as well.  Depression With Somatic Symptoms This is probably the most important one. Very common symptoms of depression include headaches, stomach ache, muscle pain, sore back. These are very common physical symptoms of depression and ones that we have to make sure that we aren't ignoring to make sure that they get the care. A lot of people go into the medical system complaining of physical symptoms only to find out that nothing is wrong and they can't understand it, and it could be depression. Not always—please always go and get a medical checkup—but it could be.  Depression Symptoms In Teens All of the symptoms I've shared above could be present in teens as well. Like I said, these are not categories that are only just for these categorical lots of people.  General overwhelming sense of apathy Commonly with teens is this general overwhelming sense of apathy like, “I don't care. I don't care about you, I don't care about me, I don't care about school.” Often parents can interpret this as like, “Oh my god, my kid is horrible.” But again, we have to make sure we're assessing for depression first. Excessive guilt I did have that as the mnemonic under O (only me to blame), but this shows up a lot in kids and teens—excessive saying I'm sorry, excessive apologizing, feeling hyper-responsible for everything that happens, feeling hyper-responsible for the social issues and drama that's happening at school, ruminating a lot about that. Again, this is common for anybody, very common for anybody with depression as well, but with teens, it really does start to spike.  Preoccupation with death or on death Again, this could be true for other categories or any human being, but we do see it show up a lot in teens—a preoccupation on death regarding movies, music, shows, or books they're reading. Just really a heavy focus on things related to death or very dark, dark topics, aggressive topics. This can play out in many ways. Again, it could also be very normal behavior and that could be something that brings them great pleasure. But again, I'm only bringing it up because these are common unknown depression symptoms that you don't possibly know could be a symptom of depression. I think it's better to be educated than to ignore it and not know.  That's the 15 depression symptoms you may not know about. One thing to consider, and I did touch on this during the episode, is commonly we have to look at depression symptoms versus anxiety symptoms. The truth is, many of these are also symptoms of anxiety. Let's go through some of them. Anger, irritability, aggressiveness—true for anxiety. Sexual desire—true for anxiety, engaging in high-risk activities—true for anxiety. A need for alcohol and drugs—true for anxiety. We do notice some perinatal symptoms and perimenopausal symptoms impact anxiety as well, but we're specifically weren't speaking to those today. But if we move into the kids category: outbursts, difficulty maintaining relationships, sensitivity to failure, frequent absences, somatic symptoms, guilt, apathy, preoccupation—these are also very common in anxiety.  What I want you to leave with today is this: Take everything you learnt today. I hope that this didn't create more anxiety for you. Just take it as knowledge. Take it as something you now know so that you can be an informed consumer, an informed patient, an informed client with your therapist so that you can know. I will say, if I'm speaking completely vulnerably, reading all the research I did made me very anxious because I have a close to teen child and I was thinking, oh my gosh, what happens if this starts to go down this track and looking at the statistics of suicide and so forth. It is anxiety provoking. But what I did in that moment—and if this helps you, I hope it does—is I said to myself, “Kimberley, you're better to be informed and practice not ruminating and doing mental compulsions about this and catastrophizing than you are to not know at all.” Here I have an opportunity to practice all of the response prevention skills, the mindfulness skills, the self-compassion skills that I have in my tool belt and that you hopefully have in your tool belt if you've been a long-term listener here on Your Anxiety Toolkit. We're going to use those tools to help us manage this, but we're going to practice being an informed consumer here. I hope this has been helpful. They are the 15 depression symptoms you may not know about and now you know.  Thank you, guys. I'm so happy to be here with you today. Stick around because some pretty exciting things are coming up. A lot of you know we had the mental compulsion series last year. This year, we are having a full sexual health related to mental health series that is just around the corner. It is going to be so incredible. I have some amazing doctors, psychiatrists, sex therapists, educators coming on to talk specifically with you around specific issues, around sexual health related to anxiety and depression. I'm so, so excited, so proud, and so honored to get to do this work with you.  All right, I'm going to hit the road. Have a wonderful day. It is a beautiful day to do hard things, and I'll see you next week.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.27.530253v1?rss=1 Authors: Giannakakis, E., Vinogradov, O., Buendia, V., Levina, A. Abstract: Experimental studies have shown that in cortical neurons, excitatory and inhibitory incoming currents are strongly correlated, which is hypothesized to be essential for efficient computations. Additionally, cortical neurons exhibit strong preference to particular stimuli, which combined with the co-variability of excitatory and inhibitory inputs indicates a detailed co-tuning of the corresponding populations. Such co-tuning is hypothesized to emerge during development in a self-organized manner. Indeed, theoretical studies have demonstrated that a combination of plasticity rules could lead to the emergence of E/I co-tuning in neurons driven by low noise signals from feedforward connections. However, cortical signals are very noisy and originate in highly recurrent networks, which raises a question on the ability of known plasticity mechanisms to self-organize co-tuned connectivity. We demonstrate that high noise levels combined with random recurrence destroy co-tuning. However, we demonstrate that introducing structure in the connectivity patterns of the recurrent E/ I network, the recurrence does not hinder but enhances the formation of the co-tuned selectivity. We employ a combination of analytical methods and simulation-based inference to uncover constraints on the recurrent connectivity that allow E/I co-tuning to emerge. We find that stronger excitatory connectivity within similarly tuned neurons, combined with more homogeneous inhibitory connectivity enhances the ability of plasticity to produce co-tuning in an upstream population. Our results suggest that structured recurrent connectivity controls information propagation and can enhance the ability of synaptic plasticity to learn input-output relationships in higher brain areas. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

En discutant avec une cliente, j'ai pris conscience que la nouvelle année pouvait aussi nous mettre une pression énorme : nouveaux objectifs, nouveaux rêves, une tonne d'actions à poser. Un plan détaillé pis beaucoup de sorties de zone de confort. Pour bien des gens, c'est excitant mais pour d'autres, ça peut aussi être un stress important. Tellement qu'il peut te paralyser et t'empêcher de passer à l'action. Alors, comment faire pour que ton année soit aussi extraordinaire que tu l'avais planifiée si tu te sens stressée? Je t'en parle dans ce premier épisode de 2023! Bonne écoute! P.S. Pour rejoindre l'Académie Exaltée : www.audreetrudel.com/exaltee

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.23.525139v1?rss=1 Authors: Akbarain, F., Rossi, C., Costers, L., Dhooghe, M., Dhaeseleer, M., Nagels, G., Van Schependom, J. Abstract: Background: Multiple sclerosis (MS) is a neurodegenerative disease characterized by neuronal and synaptic loss, resulting in an imbalance of excitatory and inhibitory synaptic transmission and potentially cognitive impairment. Current methods for measuring the excitation/inhibition (E/I) ratio are mostly invasive, but recent research combining neurocomputational modeling with measurements of local field potentials has indicated that the slope with which the power spectrum of neuronal activity captured by electro- and/or magnetoencephalography rolls off, is a non-invasive biomarker of the excitation/inhibition (E/I) ratio. A steeper roll-off is associated with a stronger inhibition. This novel method can be applied to assess the E/I ratio in people with multiple sclerosis (pwMS), detect the effect of medication such as benzodiazepines, and explore its utility as a biomarker. Methods: We recruited 44 healthy control subjects and 95 people with multiple sclerosis (pwMS) who underwent resting-state magnetoencephalographic recordings. The 1/f spectral slope of the neural power spectra was calculated for each subject and for each brain region. Results: As expected, the spectral slope was significantly steeper in pwMS treated with benzodiazepines compared to pwMS not receiving this medication (p = 0.01). In the sub-cohort of pwMS not treated with benzodiazepines, we observed a steeper slope in cognitively impaired pwMS compared to cognitively preserved pwMS (p = 0.01) and healthy subjects (p = 0.02). Furthermore, we observed a significant correlation between 1/f slope and verbal and spatial working memory functioning in the brain regions located in the prefrontal and parietal cortex. Conclusions: In this study, we highlighted the value of the spectral slope, a novel non-invasive biomarker of the E/I ratio, in MS by quantifying the inhibitory effect of benzodiazepines and by putting it forward as a potential biomarker of cognitive deficits in pwMS. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode, I discuss the physiology of smooth muscle cell contraction and how it differs from skeletal muscle cell contraction. 

In this episode, we review the high-yield topic of Spread of Excitation from the Cardiovascular section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets --- Send in a voice message: https://anchor.fm/medbulletsstep1/message

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Broads Next Door Episode 2: You're Being Hysterical In this episode we get into sleepover rituals, stuff we watched when that we shouldn't have as kids, cases of psychogenic illness & the most popular (vibrating) myth about curing female hysteria. Sources: Barker, K. Brandon, and Rice, Claiborne. 2012. "Folk Illusions: An Unrecognized Genre of Folklore." Journal of American Folklore Bartholmew, Robert. 2009, Little Green Men, Meowing Nuns & Head Hunting Panics Butkus, Cathy Jo. 1977. “Ouija Whirlwind.” Fife Folklore Archive, Utah State University. Comella, Lynn 2017. Vibrator Nation Cursed History, Cat Nuns of France, YouTube Didion, Joan. 2011. Blue Nights Dodson, Bette. 2016. Sex by Design: The Betty Dodson Story Ellis, Bill. 1994. Speak to the Devil: Ouija Board Rituals Among American Adolescents Gandes, Alan. 2002. Bloody Mary in the Mirror: A Ritual Reflection of Pre-Pubescent Anxiety Prefrontal Lobotomy in the Treatment off Mental Disorders (GWU, 1942) Lieberman, Halley, 2020. (Almost) Everything You Know About the Vibrator is Wrong Lieberman, Halley, 2017. Buzz: The Stimulating History of the Sex Toy Maines, Rachel. 2001. The Technology of Orgasm Morley, Carol, 2014 Mass Hysteria is a Powerful Group Activity National Geographic, Cleopatra's Vibr. YouTub Beattie M, Lenihan P (2018). Counselling Skills for Working with Gender Diversity and Identity. London: Jessica Kingsley Publishers Rhode Island Medical Journal, Psychiatric Casualties of The Exorcist, 1974 Nerve-Vibration and Excitation, J. Mortimer Granville, M.D. J &A Churchill, 1883 --- Send in a voice message: https://anchor.fm/broadsnextdoor/message Support this podcast: https://anchor.fm/broadsnextdoor/supportThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5803223/advertisement

Ça se passe en Kazakistan aujourd'hui et c'est là France d'ici 1 mois Je dis ça, je dis rien #MacronDestitution #AssembleeNationale https://t.co/Fwu2kvZkq2Aimer, c'est se donnerL'amour est un mélange subtil de sentiments et de raison qui donne un élan vital à toutes les relations familiales. Grand fleuve qui peut tout emporter, il a besoin de ses deux rives pour le maintenir dans sa fonction : l'intelligence et la volonté. Aimer est trop souvent compris dans le seul sens de désirer et non pas dans le sens de donner et de se donner. Pour être vrai, l'amour attend toujours une réciprocité entre parents et enfants, sinon il se limite à une assimilation aux parents, à leur ressemblance, comme le font naturellement les enfants en aimant leurs parents. Il peut se dévoyer en « dévoration », les parents pouvant posséder les enfants pour eux-mêmes, ou consister à se laisser manger, dans un certain esprit de sacrifice, comme le vivent beaucoup de mamans qui n'ont plus une minute à elles et qui confondent aimer et se laisser manger. Toutes ces déviations demandent à se laisser transformées en amour vrai qui reçoit pour donner.☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆https://linktr.ee/jacksonlibon----------------------------------------------------------------------------------------------#facebook #instagram #amour #couple #nft #famille #coil #doudou #youtube #twitter #tiktok #love #reeĺs #shorts #instagood #follow #like #ouy #oyu #babyshark #lilnasx #girl #happybirthday #movie #JOHNWICK #garden #menu #deviance #duckgo #trading #khan #academy #carter #carguru #ancestry #accords #abc #news #bts #cbs #bluebook #socialmedia #whatsapp #music #google #photography #memes #marketing #india #followforfollowback #likeforlikes #a #insta #fashion #k #trending #digitalmarketing #covid #o #snapchat #socialmediamarketing #bhfyp

References Sci Signal. 2016 Aug 23; 9(442): ra83. Dr Guerra's Neuroscience lectures --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Let's talk turn-ons.  We're covering: - The mechanisms that turn the body 'on' or 'off'- Common turn-ons and turn-offs - Whether or not we can modify what gets us hot & bothered  The research referenced includes: 7 Sex Education Lessons From Emily Nagoski's 'Come As You Are.'  2015.  https://www.wbur.org/radioboston/2015/03/12/emily-nagoski. Manage Your Turn Ons and Turn Offs. Pleasure Mechanics. https://www.pleasuremechanics.com/manage-your-turn-ons-and-turn-offs/.  The Dual Control Model: The Role of Sexual Inhibition & Excitation in Sexual Arousal and Behaviour. 2007. The Psychophysiology of Sex. https://www.yourbrainonporn.com/wp-content/uploads/2020/07/YBOP-07_THE-DUAL-CONTROL-MODEL-THE-ROLE-OF-SEXUAL-INHIBITION-EXCITATION-IN-SEXUAL-AROUSAL-AND-BEHAVIOR-Janssen-Bancroft.pdf Come As You Are. 2021. Emily Nagoski. 

Ça se passe en Kazakistan aujourd'hui et c'est là France d'ici 1 mois Je dis ça, je dis rien #MacronDestitution #AssembleeNationale https://t.co/Fwu2kvZkq2Aimer, c'est se donnerL'amour est un mélange subtil de sentiments et de raison qui donne un élan vital à toutes les relations familiales. Grand fleuve qui peut tout emporter, il a besoin de ses deux rives pour le maintenir dans sa fonction : l'intelligence et la volonté. Aimer est trop souvent compris dans le seul sens de désirer et non pas dans le sens de donner et de se donner. Pour être vrai, l'amour attend toujours une réciprocité entre parents et enfants, sinon il se limite à une assimilation aux parents, à leur ressemblance, comme le font naturellement les enfants en aimant leurs parents. Il peut se dévoyer en « dévoration », les parents pouvant posséder les enfants pour eux-mêmes, ou consister à se laisser manger, dans un certain esprit de sacrifice, comme le vivent beaucoup de mamans qui n'ont plus une minute à elles et qui confondent aimer et se laisser manger. Toutes ces déviations demandent à se laisser transformées en amour vrai qui reçoit pour donner.☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆☆https://linktr.ee/jacksonlibon----------------------------------------------------------------------------------------------#facebook #instagram #amour #couple #nft #famille #coil #doudou #youtube #twitter #tiktok #love #reeĺs #shorts #instagood #follow #like #ouy #oyu #babyshark #lilnasx #girl #happybirthday #movie #JOHNWICK #garden #menu #deviance #duckgo #trading #khan #academy #carter #carguru #ancestry #accords #abc #news #bts #cbs #bluebook #socialmedia #whatsapp #music #google #photography #memes #marketing #india #followforfollowback #likeforlikes #a #insta #fashion #k #trending #digitalmarketing #covid #o #snapchat #socialmediamarketing #bhfyp

Pour la Saint-Valentin, je me demandais si vous aviez des "rituels"? Vous savez, ces petits trucs que vous faites à deux, en amoureux, et qui vous rendent tellement heureux. Ah, si vous n'en avez pas, il est temps d'en trouver, de les inventer. Laissez Jules Fontaine, auteur érotique et Déferlante, podcast sexy vous suggérer quelque idées coquines. Special Guest: Jules Fontaine.

We go on our first pandemic beer run, which includes beers from Victoria Moon Underwater & Category 12. Beers featured in this episode Moon Juice Raspberry Sour 5.5% ABV A raspberry sour in a can. A bright + lively sour ale bursting with fresh juicy raspberry. Balanced acidity with a jammy semi-sweet finish. Not overly sour, this ale is accessible to beer geeks and cider drinkers alike. Available in 473mL 4-pack cans and 30L kegs Excitation Stout Cacao Nib Espresso Stout ABV 6.4% Going around in circles along the same well-worn path? Break away from the mundane and elevate yourself to the next level of flavour with our rich, bold stout. Enhanced with cold pressed, organic espresso and raw cacao nibs, Excitation may just incite bonding in ways only previously imagined…and not due to caffeine! This beer has a lower caffeine content than decaffeinated coffee. Mentioned in this episode The Payola$ – Eyes of a Stranger Follow SmittyBrew – Instagram | Twitter --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/apintwithfriends/message