Podcasts about mechanisms

Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity. What You'll Learn: Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health. Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research. Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss. Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions. Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane. Key Takeaways: SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management. Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies. The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity. Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions. Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one’s own biology in response to health interventions. Resources: Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience. Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being. 00:12 Understanding SGLT2 Inhibitors 02:51 Mendelian Randomization and SGLT2 Inhibitors 06:24 Benefits and Mechanisms of SGLT2 Inhibitors 09:47 Discussion on Metformin 14:36 Intermittent Fasting and Ketone Supplements 17:46 Fasting, Autophagy, and Muscle Health 22:38 Exploring Glycine and N-Acetyl Cysteine 24:48 Microplastics: A Growing Concern 26:25 The Impact of Microplastics on Health 31:54 Self-Experimentation with Sulforaphane 38:33 Final Thoughts and Future Work See omnystudio.com/listener for privacy information.

Send us a textThis week we're tackling a food we all know and love: flour. But is it really as harmless as it seems? Join me as I break down the surprising science of refined flour, cravings, and hormones—plus how a few small shifts can help you take back control of your weight loss journey.We'll talk about why flour is classified as an ultra-processed food, how it hijacks hunger signals, and why it can make weight loss feel harder than it should. Don't worry, I'll make it simple, light, and easy to understand—because this is about living your best life, not stressing over bread.Quote of the Week:“Your body is your home—feed it with care.” – Unknown Citations:Monteiro et al., 2019 – Ultra-processed foods: What they are and how to identify them. Public Health Nutrition.Hall et al., 2019 – Ultra-processed diets cause excess calorie intake and weight gain. Cell Metabolism.Ludwig, 2002 – The glycemic index: Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA.Friedman, 2014 – Leptin and the regulation of body weight. American Journal of Clinical Nutrition.Volkow et al., 2013 – The addictive dimensionality of obesity. Biological Psychiatry.Slavin, 2013 – Fiber and prebiotics: Mechanisms and health benefits. Nutrients.Hu, 2011 – Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care.ADA, 2020 – Standards of medical care in diabetes—2020. Diabetes Care.Let's go, let's get it done. Get more information at: http://projectweightloss.org

Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one's for you.Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.comSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Hettas: Use code FEISTY20 for 20% off at https://hettas.com/ Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% off This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy

Why vision, mission, and values still matter in 2025—if leaders make them real Not long ago, talking about “vision” often invited sneers. Leaders who spoke about visions were mocked as spouting psychobabble. Part of the cynicism came from the poor quality of early vision statements—trite platitudes that could double as sleeping aids. But times have changed. In 2025, vision, mission, and values are essential leadership tools, yet most organisations still struggle to make them resonate with staff. Why were visions mocked in the past? In the 1980s and 1990s, many vision statements were badly written—either too vague, too long, or too clichéd. Employees saw them as irrelevant. Cynical cultures, like Australia's, dismissed them as hollow leadership exercises. Fast-forward to today, and vision has become mainstream. Companies in Japan, the US, and Europe frame it as a strategic anchor. But credibility remains the challenge: if employees can't recall the vision, they can't live it. Mini-Summary: Early visions failed because they were clichéd or irrelevant. Today they are vital, but only if staff remember and act on them. Do employees actually know their company's vision, mission, and values? Research and field experience suggest most don't. Trainers often test this by flipping framed statements on the wall and asking staff to recite them. Typically, no one remembers the vision or mission, and at best, a few values. In Japan, where employees pride themselves on discipline and detail, this gap is striking. It shows that leadership communication is failing. Employees can't live what they can't recall. Mini-Summary: Most employees cannot recite their organisation's vision, mission, or values—evidence that communication and ownership are missing. Why do so many statements fail to inspire? There are two extremes: bloated statements too long to recall, or cut-down slogans so short they become vapid clichés. Both kill engagement. Worse, leaders often draft them alone, without wordsmithing skills or input from employees. Even when teams co-create content, turnover means newcomers feel no ownership. In Japan, where lifetime employment has eroded, this turnover effect is magnified. Leaders must find mechanisms to refresh ownership constantly. Mini-Summary: Vision and value statements fail when they're too long, too short, or disconnected from employees—especially in high-turnover environments. What practices help embed vision into daily work? One proven method is daily repetition. Ritz-Carlton Hotels review their values at every shift worldwide, with even junior staff leading the discussion. Inspired by this, Dale Carnegie Tokyo holds a “Daily Dale” every morning, where team members take turns to lead the session and recites the vision, mission, and values and discuss one of 60 Dale Carnegie Human Relations Principles. This practice ensures even new hires quickly internalise the culture. Egalitarian leadership—having secretaries, not just presidents, lead—also deepens ownership. Mini-Summary: Embedding vision requires daily rituals, repetition, and egalitarian involvement, not just posters on walls. Should companies also create a “strategic vision”? Yes. Many visions describe identity—who we are and what we stand for—but not direction. During the pandemic, Dale Carnegie Tokyo added a “Strategic Vision” to articulate where the company was heading. In 2025, with Japan navigating digital transformation, demographic decline, and global competition, leaders need both: a cultural compass (vision, mission, values) and a directional map (strategic vision). Without both, organisations drift. Mini-Summary: Companies need two visions: a cultural compass for identity, and a strategic vision for direction—especially in turbulent times. How can leaders bring visions to life in 2025? Leaders must test whether employees know the vision, mission, and values. If they don't, leaders should redesign communication and embedding processes. Mechanisms like daily recitation, story-sharing, and recognition linked to values make culture tangible. The post-pandemic world has raised expectations: employees want meaningful work, and customers want values-driven partners. Leaders who treat vision statements as wallpaper risk being left behind. Mini-Summary: Leaders bring visions to life by testing recall, embedding practices into daily routines, and aligning recognition with values. Conclusion Vision, mission, and values were once dismissed as leadership fluff. Today, they are essential but often forgotten or poorly implemented. In 2025, leaders in Japan and globally must transform them into living tools—clear, repeatable, and tied to both culture and strategy. If your team can't recite your vision, mission, and values today, you don't have a culture—you have a poster. About the Author Dr. Greg Story, Ph.D. in Japanese Decision-Making, is President of Dale Carnegie Tokyo Training and Adjunct Professor at Griffith University. He is a two-time winner of the Dale Carnegie “One Carnegie Award” (2018, 2021) and recipient of the Griffith University Business School Outstanding Alumnus Award (2012). As a Dale Carnegie Master Trainer, Greg is certified to deliver globally across all leadership, communication, sales, and presentation programs, including Leadership Training for Results. He has written several books, including three best-sellers — Japan Business Mastery, Japan Sales Mastery, and Japan Presentations Mastery — along with Japan Leadership Mastery and How to Stop Wasting Money on Training. His works have also been translated into Japanese, including Za Eigyō (ザ営業), Purezen no Tatsujin (プレゼンの達人), Torēningu de Okane o Muda ni Suru no wa Yamemashō (トレーニングでお金を無駄にするのはやめましょう), and Gendaiban “Hito o Ugokasu” Rīdā (現代版「人を動かす」リーダー). In addition to his books, Greg publishes daily blogs on LinkedIn, Facebook, and Twitter, offering practical insights on leadership, communication, and Japanese business culture. He is also the host of six weekly podcasts, including The Leadership Japan Series, The Sales Japan Series, The Presentations Japan Series, Japan Business Mastery, and Japan's Top Business Interviews. On YouTube, he produces three weekly shows — The Cutting Edge Japan Business Show, Japan Business Mastery, and Japan's Top Business Interviews — which have become leading resources for executives seeking strategies for success in Japan.

In this conversation, Dr. Jason Sonners, a chiropractor and expert in hyperbaric medicine, shares his journey into the field of hyperbaric oxygen therapy (HBOT). He discusses the science behind HBOT, its mechanisms of action, and its applications in various health conditions, including cancer, brain health, and long COVID. Dr. Saunders emphasizes the importance of safety in hyperbaric therapy and the differences between soft and hard chambers. He also highlights the future of hyperbaric medicine and the growing awareness of its benefits.Chapters00:00 Introduction to Hyperbaric Medicine and Dr. Jason Sonners02:47 The Personal Journey to Hyperbaric Therapy05:50 Understanding Hyperbaric Oxygen Therapy (HBOT)09:09 Mechanisms of Healing: How HBOT Works11:48 The Role of HBOT in Cancer Treatment14:59 Comparing Soft and Hard Hyperbaric Chambers17:52 The Future of Hyperbaric Research and Applications27:00 The Science of Hyperbaric Therapy28:02 Creating Effective Protocols29:39 Combining Therapies for Optimal Results32:02 Understanding Telomeres and Aging33:10 Choosing the Right Hyperbaric Chamber39:11 Hyperbaric Therapy for Long COVID41:58 Addressing Brain Injuries and Cognitive Function45:28 The Future of Hyperbaric Medicine

In this episode, Erin and Autumn welcome Tim, a registered nurse, to discuss the dark side of nursing through the cases of Niels Högel and Charles Cullen, both male nurses who committed heinous crimes. The conversation explores the motivations behind their actions, the failures of hospital systems to protect patients, and the emotional toll on healthcare professionals. The hosts emphasize the importance of trust in healthcare and reflect on the need to appreciate the good nurses who work tirelessly to care for patients.Chapters00:00 Introduction and Guest Introduction02:36 Tim's Nursing Background and Role03:21 Exploring Cases of Male Nurses07:12 The Case of Niels Högel07:34 Understanding the Role of Nurses in Patient Care12:16 The Mechanisms of Medical Murder17:09 The Investigation and Arrest of Högel20:07 The Trial and Conviction of Niels Högel21:32 The Aftermath and Implications for Healthcare27:39 The Role of Nurses in Healthcare28:10 Introduction to Charles Cullen29:11 The Early Life of Charles Cullen31:09 The Start of a Nightmare32:58 The Pattern of Death35:29 The Arrest of Charles Cullen37:27 The Aftermath of Cullen's Crimes39:28 The Impact on Healthcare Practices42:11 The Importance of Trust in Nursing45:32 Conclusion and Reflection48:18 outro.wavKeywordsnursing, true crime, male nurses, medical murder, Niels Högel, Charles Cullen, healthcare, hospital safety, criminal cases, podcast

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential biological mechanisms that could connect psychedelics to the aging process.0:00 - Why I'm Talking About Psilocybin3:08 - The Science of Psilocybin & Serotonin6:36 - Breaking Down The New Paper10:09 - The "Psilocybin Telomere Hypothesis"12:02 - The Cell Study: A Critical Look17:51 - The Lifespan Study in Mice (The Main Event)23:56 - How Could It Work? (Exploring the Mechanisms)30:55 - Final Thoughts & Future QuestionsProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

LEAVE A REVIEW if you liked this episode!!Let's Connect On Social Media!youtube.com/anthonyvicinotwitter.com/anthonyvicinoinstagram.com/theanthonyvicinohttps://anthonyvicino.comJoin an exclusive community of peak performers at Beyond the Apex University learning how to build a business, invest in real estate, and develop hyperfocus.www.beyondtheapex.com

Danielle Sulikowski, professor of evolutionary psychology, presents a controversial theory on why global fertility rates and birth rates are collapsing. She argues that an evolutionary strategy known as female mate suppression—where dominant women repress the reproductive success of rivals—has shifted in humans into a modern form of antinatal social contagion. Rather than direct biological suppression, the strategy manifests as propaganda and cultural messaging that discourage motherhood, promote career over family, and accelerate population decline. We explore how intrasexual competition among women could shape civilization itself, why some groups might defect against their own society to gain an evolutionary edge, and how this connects to broader debates in feminism, cultural evolution, and civilizational collapse. The conversation also ties in the density-dependent dynamics of Calhoun's Rat Utopia experiments as a possible parallel to modern urbanization, social media, and declining birth rates.PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showOUR HOMEBREWED MUSICCheck out our band's new album:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-hereVinyl pre-orders available now: https://buy.stripe.com/14A5kC3Od5d21Ms7zPdEs0900:00 Go! Introducing the Central Crisis of Western Civilization00:05:53 Intrasexual mate Suppression in Animals00:09:03 The Mechanisms of Intrasexual Competition00:12:29 Competitive Mothering Dynamics00:18:03 Advising on Haircut Strategies00:20:07 Understanding Intrasexual Competition Measurement00:21:56 Female Competitiveness Dynamics00:25:10 Personal Experiences with Gender Dynamics00:29:32 Navigating Social Circles and Competition00:33:00 Changes in Intersexual Competitiveness Among Women00:38:05 Feminism and Reproductive Suppression00:42:27 Societal Trends and Competitive Behavior00:43:10 Human Behavior and Civilization Cycles00:46:08 Decline of Birth Rates and Societal Institutions00:50:20 Reproductive Strategies and Societal Feedback Loops00:53:07 The Role of Intellectual Discourse in Civilizational Shifts00:56:15 Rationalizing Birth Rate Declines01:00:21 Evolutionary Explanations for Civilizational Behavior01:05:25 Empirical Examination of Birth Rate Decline01:09:12 Exploring Male Responses and Societal Dynamics01:12:15 Intersecting Ideologies and Population Messaging01:20:00 Internet Influence on Cultural Dynamics01:25:00 Mechanistic and Functional Explanations of Behavior01:27:03 Discussion on Societal Decline and Birth Rates01:31:21 Exploring Societal Change and Its Cyclical Nature01:35:34 The Role of Technology and Interconnectedness01:40:13 Urbanization Effects and Cultural Dynamics01:44:27 Gender Dynamics and Cultural Evolution01:47:44 Discussion on Social Influence and Elite Classes01:51:50 Class and Reproductive Strategies01:54:43 Urbanization's Impact on Society02:00:08 Evolution vs. Morality in Society02:02:57 Urban Density and Human Behavior02:07:45 Bioconservatism vs. Transhumanism02:09:00 Transhumanism and the Unknown Future02:12:53 Understanding Unseen Forces02:15:11 The Quest for Understanding#evolutionarypsychology , #civilization, #feminism, #sociology, #anthropology, #culturewars, #birthrates, #psychology, #society, #population, #decline, #history, #civilizations, #future #philosophypodcast , #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities.

Today Lee Sharkey of Goodfire joins The Cognitive Revolution to discuss his research on parameter decomposition methods that break down neural networks into interpretable computational components, exploring how his team's "stochastic parameter decomposition" approach addresses the limitations of sparse autoencoders and offers new pathways for understanding, monitoring, and potentially steering AI systems at the mechanistic level. Check out our sponsors: Oracle Cloud Infrastructure, Shopify. Shownotes below brought to you by Notion AI Meeting Notes - try one month for free at ⁠⁠⁠⁠https://⁠⁠notion.com/lp/nathan Parameter vs. Activation Decomposition: Traditional interpretability methods like Sparse Autoencoders (SAEs) focus on analyzing activations, while parameter decomposition focuses on understanding the parameters themselves - the actual "algorithm" of the neural network. No "True" Decomposition: None of the decompositions (whether sparse dictionary learning or parameter decomposition) are objectively "right" because they're all attempting to discretize a fundamentally continuous object, inevitably introducing approximations. Tradeoff in Interpretability: There's a balance between reconstruction loss and causal importance - as you decompose networks more, reconstruction loss may worsen, but interpretability might improve up to a certain point. Potential Unlearning Applications: Parameter decomposition may make unlearning more straightforward than with SAEs because researchers are already working in parameter space and can directly modify vectors that perform specific functions. Function Detection vs. Input Direction: A function like "deception" might manifest in many different input directions that SAEs struggle to identify as a single concept, while parameter decomposition might better isolate such functionality. Knowledge Extraction Goal: A key aim is to extract knowledge from models by understanding how they "think," especially for tasks where models demonstrate superhuman capabilities. Sponsors: Oracle Cloud Infrastructure: Oracle Cloud Infrastructure (OCI) is the next-generation cloud that delivers better performance, faster speeds, and significantly lower costs, including up to 50% less for compute, 70% for storage, and 80% for networking. Run any workload, from infrastructure to AI, in a high-availability environment and try OCI for free with zero commitment at https://oracle.com/cognitive Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive

Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us a textIn this episode of PT Snacks Podcast, we discuss the essentials of Platelet Rich Plasma (PRP) for physical therapists and students. Learn about the creation and types of PRP, its intended effects, and practical applications in treating various conditions such as osteoarthritis, ligament injuries, and tendinopathies. We also dive into the evidence supporting PRP's effectiveness and provides insights on how to communicate this information to patients. 00:00 Introduction to PT Snacks Podcast00:45 Today's Topic: Platelet Rich Plasma (PRP)01:39 Understanding PRP: What It Is and How It's Made02:50 Types of PRP: Leukocyte Rich vs. Leukocyte Poor03:31 Mechanisms of PRP: How It Works05:37 Effectiveness of PRP: When Does It Work?07:25 Further Learning and Resources08:35 Conclusion and Contact InformationMiddleton K et al. (2012). The Iowa Orthopaedic Journal – PRP in soft tissue injuries.Zhang N et al. (2013). The Scientific World Journal – Bone healing mechanisms.Park HB et al. (2011). Korean Journal of Hematology – Cytokine profiles and MMPs.Woodall JW et al. (2008). Biomedical Sciences Instrumentation – Inflammatory modulation.Zhou Y et al. (2017). Journal of Tissue Engineering – Tendon-bone interface and PRP.Chalidis B et al. (2023). Int. J. Mol. Sci. – PRP in tendon/ligament regeneration.Kobayashi Y et al. (2020). Journal of Experimental Orthopaedics – Angiogenesis and collagen in tendon healing.Hada S et al. (2024). Cureus – PRP in ACL injuries.Kalbkhani M et al. (2014). Applied Soft Computing – PRP in experimental OA.Gobbi A et al. (2014). PRP in Early OA of the Knee.Support the showWhy PT Snacks Podcast?This podcast is your go-to for bite-sized, practical info designed for busy, overwhelmed Physical Therapists and students who want to build confidence in their foundational knowledge without sacrificing life's other priorities. Stay Connected! Never miss an episode—hit follow now! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. Join the email list HERE On Instagram? Find unique content at @dr.kasey.hankins! Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less!(These are affiliate links, but I only recommend Medbridge because it's genuinely valuable.) Optimize Your Patient Care with Tindeq: Get 10% off with code PTSNACKS10: [Tindeq] ...

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Michael Lynch, Ph.D., Director of the Center for Mechanisms of Evolution at Arizona State University and Vaughn Cooper, Ph.D., professor of Microbiology and Molecular Genetics at the University of Pittsburgh, School of Medicine, examine the origins and trajectory of early microbial life (EML) and discuss the collaborative report between the American Academy of Microbiology and the Gordon and Betty Moore Foundation, which explores the journey of life on Earth, from non-living chemical compounds to early unicellular life, to the vast diversity of organisms we see today. This episode is brought to you by the American Academy of Microbiology, a think tank at American Society for Microbiology and the Gordon and Betty Moore Foundation, which has been dedicated to advancing scientific discovery for the past 25 years. Links for This Episode: Project Report Early Microbial Life: Our Past, Present and Future. Article: The Great Oxidation Event: How Cyanobacteria Changed Life. MTM Podcast: From Hydrothermal Vents to Cold Seeps: How Bacteria Sustain Ocean Life With Nicole Dubilier. Take the MTM listener survey! 

Today, Asif and Ali discuss the news making comedy series ‘South Park' (1:35). They discuss the show's creation, early development and success (and why Ali didn't like it initially). They discuss famous episodes as well as other successes from Trey Parker and Matt Stone including the South Park Movie, Team America: World Police and The Book of Mormon. Finally, they discuss the recent $1.5 billion deal they reached with Paramount, as well as the show satirizing and skewering President Donald Trump. Then the guys discuss pickleball injuries (30:32)…after Ali explains the game and they both make fun of it for a bit. Asif then explains how pickleball injuries have been on the rise with the exponential popularity of the game. Asif talks about how common these injuries are, who is at risk and what part of the body is most commonly injured. Finally, Asif discusses how to prevent pickleball injuries. The opinions expressed are those of the hosts, and do not reflect those of any other organizations. This podcast and website represents the opinions of the hosts. The content here should not be taken as medical advice. The content here is for entertainment and informational purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. Music courtesy of Wataboi and 8er41 from PixabayContact us at doctorvcomedian@gmail.com‘South Park' creators reach $1.5-billion streaming deal with Paramount” https://www.latimes.com/entertainment-arts/business/story/2025-07-21/south-park-creators-reach-breakthrough-in-paramount-deal-talks‘South Park' premiere skewers Trump and Paramount in fiery return”: https://www.cnn.com/2025/07/24/entertainment/south-park-premiere-trump-paramountIncreasing Incidence of Pickleball Injuries Presenting to US Emergency Departments: A 10-year Epidemiologic Analysis of Mechanisms and Trends: https://pmc.ncbi.nlm.nih.gov/articles/PMC11758564/Pickleball injuries are on this rise. Here are 10 tips to avoid them while playing: https://health.ucdavis.edu/news/headlines/pickleball-injuries-are-on-this-rise-here-are-tips-to-avoid-them-while-playing/2024/08 Hosted on Acast. See acast.com/privacy for more information.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy.   References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15   Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Dynamic Aging Retreat Oct 3-5 2025This Episode's Show NotesJoin Our Newsletter: Movement Colored GlassesIn this episode, Katy Bowman and Jeannette Loram dive into the fascinating relationship between blood sugar, diet, and movement. They unpack how the body regulates blood sugar, what happens when this process breaks down in Type I and Type II diabetes, and why different kinds of activity play such a big role in prevention and management.Katy and Jeannette explain how contracting muscles can pull glucose directly into working cells during exercise—a powerful but site-specific effect—and how long-term training reshapes muscle to take up glucose more efficiently.They also compare the blood sugar benefits of endurance exercise, resistance training, HIIT, stretching, and even light daily movement. Along the way, they highlight two key scenarios: insulin resistance linked to excess weight and inflammation, versus insulin resistance driven by low muscle mass in people with normal weight. For the latter, they stress why resistance training—or “big body work”—is especially essential.CHAPTERS 0:06:00 - Definitions 0:16:00 - The Dynamic Collective 0:17:00 - You Can't Exercise Off Diabetes 0:20:00 - Muscle is the Key Tissue (and the Liver)0:36:30 - Stretching & Light Activity 0:47:00 - Exercise Modality for Blood Sugar Regulation0:54:25 - Listener Question on Lupus brought to you by Peluva 1:09:09 - Blood Sugar Spikes During Exercise BOOKS & RESEARCH PAPERS My Perfect Movement Plan by Katy BowmanI know I should Exercise, But... by Diana Hill & Katy BowmanExercise and GLUT4 by Flores-Opazo et al (2020) Mechanisms of endurance and resistance exercise in type 2 diabetes by Zhao et al (2025)  Sedentary behaviour as a mediator of type 2 diabetes by Hamilton et al (2015) Impact of reduced sitting time or increasing sit-to-stand transitions on blood pressure and glucose regulation in Postmenopausal women by Hartman et al (2025) The impact of standing desks on cardiometabolic and vascular health by Bodker et al (2021) MADE POSSIBLE BY OUR WONDERFUL SPONSORS:Sweet Skins, organic hemp and cotton clothing that is stylish, flexible and designed to move with you, take 20% off with code Movement20Peluva, Five-toe minimalist sports shoes ideal for walking and higher impact activities. Take 15% off with code NUTRITIOUSMOVEMENTIkaria Design, creators of the Soul Seat®, a height adjustable chair that allows you to sit in diverse shapes including cross-legged, take 10% of new inventory with code DNA10Venn Design, beautiful floor cushions and ball seats that keep you moving at home or at the officeEarth Runners, minimalist sandals that mimic being truly barefoot through their grounding technology, take 10% off with code DNA10Smart Playrooms, design and products to keep you and your kids engaged and active at home, take 10% off monkey bars, rock wall panels and holds with code DNA10

در اسلایدکست دوم،به کامپوزیتهایی میپردازیم که به علت خاصیت chameleon effect همرنگ دندان اطراف دیده میشندر مورد علت تکنولوژی مزایا معایب این کامپوزیت‌ها صحبت میکنیمدر هقت دقیقه و با اسلاید بیاموزیداسلایدکست روش دیگه ی آموختنه،با اسلاید و هوش مصنوعیبرای استفاده ی تصویری به کانال تلگرام مراجعه کنید⚡️⚡️ دکتر فؤاد شهابیان ⚡️⚡️متخصص پروتزهای دندانی Hosted on Acast. See acast.com/privacy for more information.

Lung Cancer Considered--STK11 and KEAP1 as resistance mechanisms to immunotherapy by IASLC

Neurologist Michelle Monje studies the close relationship between cancer and the nervous system, particularly in an aggressive brain cancer that often strikes in childhood. Her research shows that the cancer cells are electrically integrated into the brain itself and these connections actually help the cancer to grow. Monje and collaborators have now developed an immunotherapy that has shown great promise in mice and early human trials. One patient had a “complete response” and is cancer-free four years after treatment, Monje tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Michelle MonjeConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces guest Michelle Monje, a professor of pediatric neurology at Stanford University.(00:03:39) Focus on Cancer ResearchMonje's clinical observations led to exploring cancer-neuron interactions.(00:05:28) Neurons and Glial CellsThe role of neurons and glial cells in brain function and disease.(00:08:32) Gliomas in ChildrenAn overview of gliomas and their origins in glial precursor cells.(00:10:12) Rethinking Brain Cancer BehaviorHow gliomas don't just grow—they integrate with brain circuits.(00:14:49) Mechanisms of Tumor GrowthTwo primary mechanisms by which cancer exploits the nervous system.(00:16:32) Synaptic Integration of Cancer CellsThe discovery that glioma cells form synapses with neurons.(00:20:06) CAR T-Cell TherapyAdapting CAR T-cell immunotherapy to target brain tumors.(00:22:52) Targeting GD2 AntigenIdentification of a surface marker enables precision CAR T-cell therapy.(00:24:35) Immune Access to the BrainThe ability of CAR T-cells to reach the brain, despite prior understanding.(00:26:16) First Clinical Trial ResultsThe significant tumor reduction and response from CAR T-cell therapy.(00:28:21) Combined TherapiesPairing immune therapy with neural signaling blockers for better outcomes.(00:30:35) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

Deep dive with Dan Hendrycks, a leading AI safety researcher and co-author of the "Superintelligence Strategy" paper with former Google CEO Eric Schmidt and Scale AI CEO Alexandr Wang.*** SPONSOR MESSAGESGemini CLI is an open-source AI agent that brings the power of Gemini directly into your terminal - https://github.com/google-gemini/gemini-cliProlific: Quality data. From real people. For faster breakthroughs.https://prolific.com/mlst?utm_campaign=98404559-MLST&utm_source=youtube&utm_medium=podcast&utm_content=script-gen***Hendrycks argues that society is making a fundamental mistake in how it views artificial intelligence. We often compare AI to transformative but ultimately manageable technologies like electricity or the internet. He contends a far better and more realistic analogy is nuclear technology. Like nuclear power, AI has the potential for immense good, but it is also a dual-use technology that carries the risk of unprecedented catastrophe.The Problem with an AI "Manhattan Project":A popular idea is for the U.S. to launch a "Manhattan Project" for AI—a secret, all-out government race to build a superintelligence before rivals like China. Hendrycks argues this strategy is deeply flawed and dangerous for several reasons:- It wouldn't be secret. You cannot hide a massive, heat-generating data center from satellite surveillance.- It would be destabilizing. A public race would alarm rivals, causing them to start their own desperate, corner-cutting projects, dramatically increasing global risk.- It's vulnerable to sabotage. An AI project can be crippled in many ways, from cyberattacks that poison its training data to physical attacks on its power plants. This is what the paper refers to as a "maiming attack."This vulnerability leads to the paper's central concept: Mutual Assured AI Malfunction (MAIM). This is the AI-era version of the nuclear-era's Mutual Assured Destruction (MAD). In this dynamic, any nation that makes an aggressive, destabilizing bid for a world-dominating AI must expect its rivals to sabotage the project to ensure their own survival. This deterrence, Hendrycks argues, is already the default reality we live in.A Better Strategy: The Three PillarsInstead of a reckless race, the paper proposes a more stable, three-part strategy modeled on Cold War principles:- Deterrence: Acknowledge the reality of MAIM. The goal should not be to "win" the race to superintelligence, but to deter anyone from starting such a race in the first place through the credible threat of sabotage.- Nonproliferation: Just as we work to keep fissile materials for nuclear bombs out of the hands of terrorists and rogue states, we must control the key inputs for catastrophic AI. The most critical input is advanced AI chips (GPUs). Hendrycks makes the powerful claim that building cutting-edge GPUs is now more difficult than enriching uranium, making this strategy viable.- Competitiveness: The race between nations like the U.S. and China should not be about who builds superintelligence first. Instead, it should be about who can best use existing AI to build a stronger economy, a more effective military, and more resilient supply chains (for example, by manufacturing more chips domestically).Dan says the stakes are high if we fail to manage this transition:- Erosion of Control- Intelligence Recursion- Worthless LaborHendrycks maintains that while the risks are existential, the future is not set. TOC:1 Measuring the Beast [00:00:00]2 Defining the Beast [00:11:34]3 The Core Strategy [00:38:20]4 Ideological Battlegrounds [00:53:12]5 Mechanisms of Control [01:34:45]TRANSCRIPT:https://app.rescript.info/public/share/cOKcz4pWRPjh7BTIgybd7PUr_vChUaY6VQW64No8XMs

Dietitians Aidan Muir & Leah Higl discuss the role of collagen supplementation in skin health. They cover the mechanisms behind collagen and skin health, appropriate dosages, and present arguments for and against its effectiveness as a supplement.    (0:09) - Introduction (0:43) - Mechanisms  of Collagen (1:25) - Dosage & How to Take (2:15) - Arguments For Taking Collagen (5:10) - Arguments Against Taking Collagen (9:21) - Summary & Takeaways   WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en   Our dietitians

What if one of the brain's most important defenses was hiding in plain sight? In this episode, we take a look at lithium, a trace element found in water, food, and the brain itself. Long before brain scans, people made pilgrimages to lithium-rich springs, swearing the waters restored their health. A century later, it became a psychiatric drug. But new research from Harvard Medical School has uncovered something unique: lithium is a master regulator in the brain, and one of the earliest changes in Alzheimer's disease is that it disappears. We follow the evidence from historical clues to modern lab discoveries, revealing how amyloid plaques trap lithium, how that loss accelerates neurodegeneration, and how restoring it at nutritional doses could help preserve memory (without the risks of high-dose therapy).00:00 Introduction: The Mystery of Aging and Dementia00:42 The History and Discovery of Lithium01:31 Lithium's Role in Mental Health01:53 Lithium and Cognitive Decline03:18 Harvard's Breakthrough Research05:01 Mechanisms of Lithium in the Brain07:34 Clinical Studies and Trials09:13 Nutritional Lithium: Dosage and Sources11:22 Conclusion: implying the brain is exquisitely sensitive to Li levels.PMID: 40770094PMID: 17401045PMID: 20148870PMID: 18981345PMID: 39212809PMID: 22746245PMID: 30066063Support the show

On this episode, Ben Azadi sits down with quantum wellness expert Todd Shipman for a fascinating deep dive into the unseen forces affecting your health—electromagnetic fields (EMFs) and quantum energy. Todd shares his personal journey and reveals how Leela Quantum's cutting-edge tools, like the Infinity Block and Quantum Upgrade, are designed to shield the body from EMF stress, supercharge your mitochondria, and boost heart rate variability. Think of it as creating a “protective bubble wrap” around your body—helping you feel calmer, more energized, and better equipped to thrive in today's tech-saturated world. Backed by compelling science and real-world stories, this conversation offers practical ways to protect your health, optimize your metabolism, and live with less stress—even when you're surrounded by screens and devices.

Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Today we're switching gears a bit to talk about a medication rather than a peptide — metformin. If you're someone who's interested in peptides for metabolic health or inflammation, you've probably heard metformin mentioned alongside them. It's been around for decades as a diabetes medication, but recently it's gaining attention for its potential benefits beyond blood sugar, including longevity, inflammation, and neuroprotection — even in people who don't have diabetes. Let's get into it. Metformin and Longevity Can metformin really help us live longer? One of the biggest sparks came from a 2014 study published in Diabetes, Obesity and Metabolism, where researchers found that diabetics on metformin actually lived longer than non-diabetics not taking the medication.  The authors suggested that metformin may offer protective benefits beyond glucose control, possibly by reducing oxidative stress and slowing cellular aging. This inspired the launch of the TAME trial—short for Targeting Aging with Metformin—which is designed to test whether metformin can delay the onset of age-related diseases like cancer, cardiovascular disease, and cognitive decline. While results are still pending, it's the first large-scale effort to study aging as a treatable condition, not just a process. Inflammation and Immunometabolism Next up: inflammation. Chronic low-grade inflammation is at the root of so many health issues—heart disease, dementia, even depression. Metformin appears to blunt systemic inflammation by activating AMPK. Think of AMPK as a metabolic master switch that lowers inflammatory signaling. A 2021 review published in Pharmacological Research found that metformin can inhibit NF-κB, a major pathway that drives inflammation. It also helped lower levels of CRP—a protein made by the liver that rises when there's inflammation from things like infection, injury, or chronic disease—and IL-6, another immune system protein commonly elevated in chronic inflammatory conditions. Because of these anti-inflammatory effects, researchers have been exploring metformin's potential in conditions beyond diabetes, including autoimmune diseases, multiple sclerosis (MS), PCOS, and even COVID—where it's been linked to lower mortality in patients with diabetes. Brain Health and Neuroprotection What about the brain? Can metformin help protect against cognitive decline? There's some promising data here too. A 2017 study in Aging Cell found that metformin improved neurogenesis in the hippocampus of aged mice—basically, helping old brains grow new neurons. In 2019 a cohort study in JAMA Network reported that people with type 2 diabetes taking metformin had a lower risk of developing dementia compared to those not taking it. Mechanisms may include reduced insulin resistance in the brain, less oxidative stress, and—again—AMPK activation, which promotes mitochondrial health and energy production. Still, human trials are mixed, and more controlled research is needed before we can call it a “smart drug.” Lower Cancer Risk So, here's an interesting one—can metformin actually lower the risk of cancer? Well, the short answer is: maybe. People with diabetes tend to have a higher risk of developing certain types of cancer, so part of metformin's benefit could just come from better managing blood sugar and insulin levels. But what's really exciting is that researchers think metformin might do even more than that. There's evidence suggesting it could have direct effects on cancer cells—like slowing down their growth or making the environment less friendly for tumors. Some studies have found lower rates of cancers like breast, colon, and prostate in people taking metformin. Now, this isn't a magic bullet or anything, but it's a promising area of research that's getting a lot of attention. So metformin might be pulling double duty: managing diabetes and potentially helping reduce cancer risk through other mechanisms we're still learning about. Metabolic Health for Non-Diabetics Now here's where it gets controversial—should healthy people without diabetes be taking metformin? Some researchers argue yes, especially for people with metabolic syndrome, prediabetes, or high inflammation. Metformin improves insulin sensitivity, reduces liver glucose production, and may even support modest weight loss. That said, there are tradeoffs. Metformin can cause stomach-related side effects (e.g., nausea, gas, heartburn, and diarrhea) and vitamin B12 deficiency (which may lead to nerve damage). It can also cause extreme fatigue.  Metformin may sometimes cause sexual side effects, like erectile dysfunction in men. Some studies suggest it might lower testosterone, which we know is important for male sexual health. But interestingly, other research points to metformin actually improving blood flow to the penis, which could help with erectile issues. So, it's a bit of a mixed picture—and it really depends on the individual. And although rare, it can cause lactic acidosis (a life threatening condition where lactic acid builds up in the blood) in older adults, people with advanced kidney disease, or those who drink excessive amounts of alcohol. So it's not a free pass.  So what are my final thoughts and who should you take metformin for longevity? Metformin isn't a one-size-fits-all solution, and it's definitely not something to start just because you heard about it on a podcast. We still need more research—especially in people without diabetes—to really understand who benefits most. But it might make sense for some people, like those with prediabetes, PCOS, metabolic syndrome, or even older adults looking to support healthy aging.  As always, it's something to talk through with your healthcare provider.  The science is exciting, but it's all about finding what makes sense for you. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going.  Until next time, be well, and as always, have a happy, healthy week.

In this episode, we dive into the less obvious signs of under-recovery, and why your nervous system, not just your habits, might be the missing piece. But first, we chat about what 5 key aspects to focus on if you're knee-deep in a fall marathon prep. Then, we break down what recovery actually means, how cortisol and hormone shifts affect your sleep and progress, and why fueling and stress perception play a bigger role than you think.Whether you're an endurance athlete, a lifter, or just someone trying to train with intention, this episode will help you rethink how you approach rest, training adaptation, and energy. Because more effort isn't always the answer, smarter recovery is.We'll also give you a clear checklist to spot recovery gaps and practical strategies you can start using today.www.trainmk.com@melissa_kendterMcEwen, B. S., & Stellar, E. (1993). Stress and the individual. Mechanisms leading to disease. Arch Intern Med, 153(18), 2093-2101.Mountjoy, M. et al. (2018). IOC consensus statement: Relative Energy Deficiency in Sport (RED-S). Br J Sports Med, 52(11), 687–697.Harvard Health Publishing (2020). How stress affects the brain and body.American College of Sports Medicine. (2021). ACSM's Guidelines for Exercise Testing and Prescription (11th ed.).Stanford Medicine HRV Research Lab: HRV as a marker of training recovery.

In this continuation of our series The 12 Key Challenges in Breeding and Creating a Strain, Episode 150 dives deep into the complexities of establishing a true, purebred strain—examining the connection and similarities between evolutionary biology and selective breeding practices. Breeders striving for perfection face a wide range of challenges, from genetic issues to environmental influences, and this episode uncovers the scientific foundations and practical strategies for overcoming them. We'll explore the 4 Mechanisms of Evolution identified by Charles Darwin—variation, inheritance, overproduction of offspring, and differential survival and reproduction—and how these principles relate directly to selective breeding. As breeders select for specific traits, understanding these natural processes is key to creating a healthy, viable strain over time. Challenges #6-8 focus on: Dealing with Epigenetics: The way environmental factors, such as geography, nutrition, and management, can influence genetic expression in ways that go beyond traditional inheritance. We'll break down how breeders can harness epigenetic mechanisms for the betterment of their strains, while managing the effects of undesirable traits. Gene Flow and Genetic Instability: How the continuous influx of external genes through practices like outcrossing and crossbreeding can affect the purity of a strain. Learn how breeders can manage and even halt gene flow to avoid genetic dilution and ensure the integrity of their breed. Genetic Drift: The unpredictable changes in genetic composition that occur in small populations. Discover how breeders can use genetic drift to their advantage, preserving and enhancing strains during periods of reduced numbers, while avoiding its pitfalls, such as bottlenecking. By understanding the science behind selective breeding and the biological forces that drive evolution, breeders can make informed decisions that will help them create strong, sustainable strains. Whether you're a seasoned breeder or just starting out, this episode is packed with valuable insights to help you navigate the challenges of breeding for excellence. Tune in for a deeper understanding of how evolutionary biology intersects with breeding practices and how you can apply this knowledge to your own breeding program. Don't forget to bring your questions—we're here to help you grow your breeding knowledge! Make sure to follow and watch our future shows. We plan to dive deep into the world of breeding and genetics, nutrition and health management, and provide essential tips, so you too can create high quality strains.  Whether you're breeding domestic chickens, gamefowl, or various types of livestock, this show is for you.  Join us on Bred to Perfection Live, Friday's at 6pm PST or 9pm EST on YouTube, as we discuss the benefits of creating your own strain. See ya there! Kenny Troiano Founder of "The Breeders Academy"   We specialize in breeding, and breeding related topics. This includes proper selection practices and the use of proven breeding programs. It is our mission to provide our followers and members a greater understanding of poultry breeding, poultry genetics, poultry health care and disease prevention, and how to improve the production and performance ability of your fowl.  If you are interested in creating a strain, or improving your established strain, you are in the right place.  We also want to encourage you to join us at the Breeders Academy, where we will not only help you increase your knowledge of breeding and advance your skills as a breeder, but improve the quality and performance of your fowl. If you would like to learn more, go to: https://www.breedersacademy.com

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page.  Mind Pump Fit Tip: Ten Ways to Dramatically Improve Workout Consistency. (1:31) One of the EASIEST ways to bump protein and cut calories. (27:47) When you have kids, it's not about you and it's about them. (31:01) Make Orwell fiction again. (37:07) Diet is religion. (39:01) Exercise and depression. (42:01) Green Juice makes you feel good. (52:17) #Quah question #1 – I love your guys' programs. I do see people comment about how Arnold presses are a terrible movement. I do see you guys have them in your programming. How do you feel about the negative comments towards that exercise? (54:54) #Quah question #2 – What is the ideal mindset to have for people starting their health and fitness journey? (58:21) #Quah question #3 – What is something I can do during long rest periods? I want to avoid phones as much as I can, only tracking sets. (1:00:24) #Quah question #4 – I'm becoming a personal trainer, mostly because of you guys, and just landed my first client. What steps should I take from here? (1:06:47) Related Links/Products Mentioned Visit Butcher Box for this month's exclusive Mind Pump offer!  ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! ButcherBox members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off** July Special: MAPS Split or Anabolic Metabolism Bundle 50% off! ** Code JULY50 at checkout ** 6 Benefits of Walking After Meals, Backed by Health Experts Mind Pump #1522: How to Stay Consistent With Your Diet & Workout Mind Pump #2612: How One Man Lost Over 300 Pounds Without Any Cardio 7 Health Benefits of Pasture-Raised Chicken You Can't Ignore George Orwell's estate approves retelling ‘1984' from woman's point of view 1984: 75th Anniversary Mind Pump #2644: Eight Best Carbs for Bodybuilding & More (Listener Live Coaching) The Effects and Mechanisms of Exercise on the Treatment of Depression The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study Get your free Sample Pack with any “drink mix” purchase! Find your favorite LMNT flavor, or share it with a friend. Try LMNT risk-free. If you don't like it, give it away to a salty friend and we'll give you your money back, no questions asked! Visit DrinkLMNT.com/MindPump Mind Pump #1447: How to Start Your Fitness Journey Trainer Bonus Series Episode 1: The Successful Trainer Mindset Trainer Bonus Series Episode 2: Diet & Exercise Strategies That Work AND Clients Love Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Jamie Selzler (@jselzler) Instagram Paul Chek (@paul.chek) Instagram  

Episode 308 hosts Dr Raquel Amado (Dental Surgeon from Kent, UK) and Dr Anoob Pakkar-Hull (Cosmetic Physician from London, UK) In our 'Masterclass Series' we host global experts to teach us about fillers, bio-stimulators, bio-remodellers, polynucleotides, exosomes and other products. (For toxin insights, check out our other mini-series, 'The Tox Talks') In Chapter 7 we discuss various different combination treatments that are commonly used in regenerative aesthetics. Raquel and Anoob discuss their experiences and insights with various treatment modalities and cocktails of microtoxin, the various biostimulators, polynucleotides, PRP and exosomes.  Our conversation also highlights their upcoming RCC meeting that will be held in the Azores. RCC will showcase experts for in-depth lectures and debates about these innovative treatments. The event is non-sponsored and aims to foster open, unbiased discussions and on the efficacy and safety of these advanced regenerative therapies. 00:00 Introduction 01:29 IA Competition Details 02:13 Introducing Dr. Raquel Amado and Dr Anoob Pakkar-Hull 07:07 Microtoxin and Combination Therapies 08:47 Exploring Regenerative Aesthetics 15:04 Microtoxin and NCTF: A Powerful Combination 22:50 Biostimulators and Bio Remodelers 32:26 PRP: Experiences and Insights 36:14 Challenges with PRP Consistency 36:49 Equipment and Variability in PRP 37:46 Historical and Current Uses of PRP 38:18 Combining PRP with Other Treatments 40:19 Introduction to Polynucleotides 40:56 Mechanisms and Benefits of Polynucleotides 43:57 Combining Polynucleotides with Other Treatments 50:27 Exosomes: Sources and Uses 53:18 Patient Communication and Treatment Customization 59:15 Debating the Efficacy of Regenerative Treatments 01:04:15 Future of Regenerative Medicine and Conferences 01:08:02 RCC Conference Overview and Invitation   FIND OUT MORE ABOUT REGENERA COLLECTIVE CONFERENCE & BUY TICKETS - IA LISTENERS GET 15% off BY USING THE CODE IA15! CHECK OUT OUR PATREON & GET A 7 DAYS FREE TRIAL! BROWSE OUR IA OFFERS FOR DISCOUNTS & SPECIALS YOUR A BRAND OR COMPANY & WANT TO WORK WITH US APPLY TO BE A GUEST ON OUR PODCAST CONTACT US  

In recent years “Zone 2 training” has gained immense popularity in fitness and health circles, often being proclaimed the “best” cardiovascular training for metabolic health.  Zone 2 training is sustained, low-intensity exercise below the lactate threshold that is commonly employed by many elite level endurance athletes, with a variety of proposed performance benefits. This led to interest from health-conscious folks about its ability to  improve markers like VO2 max and mitochondrial function, which are associated with better health outcomes and longevity.  Prof. Brendon Gurd, an exercise physiologist at Queen's University, is  the co-author of a recent review published in Sports Medicine that examined some of the claims made around zone 2 training and health in the general population. This episode looks at whether the evidence truly supports Zone 2 as a uniquely effective training zone or if this hype has outpaced the research. These insights help professionals and individuals make evidence-based recommendations and avoid unintended negative consequences of following certain ideas. About The Guest Dr. Brendon Gurd is a Professor in the School of Kinesiology and Health Studies at Queen's University, where his research focuses on exercise physiology and skeletal muscle adaptation. His work explores how different intensities and types of exercise influence mitochondrial content and function in muscle tissue, with the goal of understanding how to optimize health and performance through training. Timestamps [03:23] Discussion with Professor Brendan Gurd [05:56] Zone two training: Mechanisms and misconceptions [10:56] Practical applications and recommendations [22:16] Research gaps and future directions [35:47] Key ideas segment (Sigma Nutrition Premium) Links to Resources Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course List of Sigma's Recommended Resources Review paper: Storoschuk et al., 2025 – Much Ado About Zone 2: A Narrative Review Assessing the Efficacy of Zone 2 Training for Improving Mitochondrial Capacity and Cardiorespiratory Fitness in the General Population Lecture Slides: Prof. Brendon Gurd – Is Zone 2 the optimal intensity for inducing mitochondrial adaptation?

In this episode of the Boost Your Biology podcast, Lucas Aoun interviews Jason Gilbert, a chiropractor and advocate for hyperbaric oxygen therapy. Jason shares his journey into health and wellness, discussing the importance of understanding the causes of illness and the core pillars of health, including nutrition, movement, and sleep. They delve into the mechanisms of mild hyperbaric oxygen therapy, its benefits for recovery from conditions like long COVID, and the significance of social circles in health. Jason emphasizes the need to invest in health proactively and the physiological effects of hyperbaric therapy on the body, advocating for a holistic approach to wellnessRelevant links:Jason's Website: https://jasongilbert.com.au/ Check Out My Website For Coaching, Recommended Products and Much More:https://www.boostyourbiology.com/ Disclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. The products presented and discussed in this podcast are explicitly only relevant to those who reside in the US. The statements and discussions held within this episode, are NOT approved by the TGA. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program.Chapters00:00 Introduction to Hyperbaric Oxygen Therapy01:01 Jason's Journey into Health and Wellness09:44 Understanding the Causes of Illness11:38 Core Pillars of Health15:14 Introduction to Mild Hyperbaric Oxygen Therapy21:10 Mechanisms of Oxygen Therapy26:28 Experiences with Long COVID and Recovery29:25 The Importance of Social Circles in Health32:09 Investing in Health for the Future33:29 Physiological Effects of Hyperbaric Therapy37:30 Combining Modalities for Enhanced Health43:32 The Future of Hyperbaric Therapy Hosted on Acast. See acast.com/privacy for more information.

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In this episode, Dr. Jill is joined by Dr. Chris D'Adamo, a leading researcher in integrative health and nutritional immunology, to discuss the critical role of beta glucans in supporting and modulating the immune system.

Vitamin A is often one of the less-discussed micronutrients in relation to bone health, taking a back seat to nutrients like calcium and vitamin D. Yet this fat-soluble vitamin plays a fundamental role in skeletal development, remodeling, and mineral homeostasis. It influences gene expression in both osteoblasts and osteoclasts, and contributes to the regulation of bone turnover throughout the lifespan. But what makes vitamin A particularly interesting, and controversial, is that its effects on bone appear to follow a double-edged pattern. While it's essential for bone formation, several large epidemiological studies have suggested that chronically high intakes of preformed vitamin A may actually increase the risk of osteoporosis and fracture, especially when consumed as retinol from supplements or high-liver diets. And yet, the picture is not so clear-cut. This raises compelling questions: Is the concern over vitamin A and bone health justified, or is it a case of context-dependent risk? Can vitamin A, when combined with adequate levels of D and K, actually support bone strength? And are there thresholds above or below which risk increases? In this episode, we explore the human evidence on vitamin A and skeletal health, looking not only at fracture outcomes and bone mineral density data, but also at nutrient interactions, mechanistic plausibility, and the implications for supplement use in well-nourished populations. Note: This is a Premium-exclusive episode, so you will only hear a preview on this public feed. Timestamps [00:23] Vitamin A and bone health: an overview [02:50] Forms of vitamin A: retinol and carotenoids [04:16] Mechanisms of vitamin A in bone physiology [17:52] Nutrient interactions: vitamin A, D, and K [31:03] Practical takeaways and recommendations Related Resources Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Go to Sigma Nutrition.com Enroll in the next cohort of our Applied Nutrition Literacy course

[This is one of the finalists in the 2025 review contest, written by an ACX reader who will remain anonymous until after voting is done. I'll be posting about one of these a week for several months. When you've read them all, I'll ask you to vote for a favorite, so remember which ones you liked] “The scientific paper is a ‘fraud' that creates “a totally misleading narrative of the processes of thought that go into the making of scientific discoveries.” This critique comes not from a conspiracist on the margins of science, but from Nobel laureate Sir Peter Medawar. A brilliant experimentalist whose work on immune tolerance laid the foundation for modern organ transplantation, Sir Peter understood both the power and the limitations of scientific communication. Consider the familiar structure of a scientific paper: Introduction (background and hypothesis), Methods, Results, Discussion, Conclusion. This format implies that the work followed a clean, sequential progression: scientists identified a gap in knowledge, formulated a causal explanation, designed definitive experiments to fill the gap, evaluated compelling results, and most of the time, confirmed their hypothesis. Real lab work rarely follows such a clear path. Biological research is filled with what Medawar describes lovingly as “messing about”: false starts, starting in the middle, unexpected results, reformulated hypotheses, and intriguing accidental findings. The published paper ignores the mess in favour of the illusion of structure and discipline. It offers an ideal version of what might have happened rather than a confession of what did. The polish serves a purpose. It makes complex work accessible (at least if you work in the same or a similar field!). It allows researchers to build upon new findings. But the contrived omissions can also play upon even the most well-regarded scientist's susceptibility to the seduction of story. As Christophe Bernard, Director of Research at the Institute of Systems Neuroscience (Marseilles, Fr.) recently explained, “when we are reading a paper, we tend to follow the reasoning and logic of the authors, and if the argumentation is nicely laid out, it is difficult to pause, take a step back, and try to get an overall picture.” Our minds travel the narrative path laid out for us, making it harder to spot potential flaws in logic or alternative interpretations of the data, and making conclusions feel far more definitive than they often are. Medawar's framing is my compass when I do deep dives into major discoveries in translational neuroscience. I approach papers with a dual vision. First, what is actually presented? But second, and often more importantly, what is not shown? How was the work likely done in reality? What alternatives were tried but not reported? What assumptions guided the experimental design? What other interpretations might fit the data if the results are not as convincing or cohesive as argued? And what are the consequences for scientific progress? In the case of Alzheimer's research, they appear to be stark: thirty years of prioritizing an incomplete model of the disease's causes; billions of corporate, government, and foundation dollars spent pursuing a narrow path to drug development; the relative exclusion of alternative hypotheses from funding opportunities and attention; and little progress toward disease-modifying treatments or a cure. https://www.astralcodexten.com/p/your-review-of-mice-mechanisms-and

On this episode of the Flex Diet Podcast, I'm joined by Dr. Antonella Schwarz to geek out over her recent study on myo-reps, which she presented at the International Society of Sports Nutrition. We break down what myo-reps are, where the concept came from, and how they stack up against more traditional hypertrophy protocols.We also dive into some broader topics, including muscle growth principles, physical therapy applications, injury recovery strategies, and how to train efficiently when time is tight. Dr. Schwarz shares how she uses myo-reps in her own training and why performance-based goals are such a big deal. Plus, she gives us a sneak peek at her upcoming researchIf you're a coach, trainer, or just a curious nerd like me, you'll get a ton out of this one. Enjoy!Sponsors:Tecton Life Ketone drink! https://tectonlife.com/ DRMIKE to save 20%LMNT electrolyte drink mix: miketnelsonlmnt.comAvailable now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:04:25 Discussion on Myo Reps Study06:10 Defining Myo Reps and Its Origins08:41 Mechanisms and Benefits of Myo Reps12:34 Strength vs. Hypertrophy Training15:52 Challenges in Hypertrophy Research28:10 Study Design and Findings39:16 Future Research and Personal Training Insights40:36 Respect for Bodybuilding and Hypertrophy Training41:41 Current Training and Goals43:02 Balancing Aerobic and Strength Training45:03 Debunking Fitness Myths50:47 Journey into Sports Science and Academia53:27 Challenges in Sports Medicine Practices01:04:18 Importance of Performance Goals01:10:32 Upcoming Projects and Research01:13:24 Podcast Conclusion and Announcements Episode Flex Diet Podcast Episodes You May Enjoy:Episode 161: Muscle hypertrophy, exercise selection, and nutrient timing, an interview with Dr Chester Soko - https://youtu.be/0snSfWTuVYQEpisode 149: Strength, Hypertrophy and Training Research Update from the REC Conference by Discover Strength 2022 - https://youtu.be/szaHgTw8HZ8Connect with Dr Schwarz:Instagram: https://www.instagram.com/dr.antonella.schwarz/The Rehabilitation Lab: https://www.barry.edu/en/academics/health-sciences/sport-and-exercise-sciences-programs/rehabilitation-lab/Get In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

Message our hosts, Kieran and Jose.Season 3 of The Animal Heartbeat is all about the Veterinary Cardiology Icons - those who walk among us as legends of the veterinary cardiology world.This episode features Professor Chris Orton of Colorado State University. Prof Orton has been a leader in the field of canine heart surgery for over thirty years, having worked to develop both open heart surgery techniques on cardiopulmonary bypass and minimally invasive techniques to treat valve disease. Chris is known as a cardiologist and a surgeon, but also has a strong bench-top research background, evaluating the mitral valve and the mechanisms of degenerative disease.Join our hosts, Jose and Kieran, as they discuss Prof Orton's research experience and his experience over the last 3-years of trans-catheter edge-to-edge mitral valve repair, patient considerations and outcomes.

The Anti-Federalists knew exactly where it would lead - unchecked power, endless taxes, and the death of the republic - and of liberty. The post The TRAP They Saw Coming: 5 Mechanisms of Tyranny first appeared on Tenth Amendment Center.

"Marcello" self-censors in efforts to feel safe. He asks Jessica for help understanding how he can get out of his own way. The two go deep into his coping mechanisms in this week's episode.

In this episode, Dr. Jockers and Dr. Rob Bello dive into the science behind BPC-157 and why it's different from conventional anti-inflammatories like NSAIDs. You'll hear how this peptide works with your body—not against it—to speed healing and reduce chronic inflammation without halting the recovery process.   You'll also discover the power of stacking BPC-157 with TB-4 Frag, a synergistic combo known as the “Wolverine Stack.” Learn how this potent pair supports tissue repair, collagen production, angiogenesis, and even hormone receptor sensitivity for faster recovery and better performance.   Curious about dosing, delivery methods, or long-term safety? Dr. Bello shares insider insights on oral bioavailability, clinical outcomes, and what makes their formulations uniquely effective—especially for athletes, autoimmune patients, and anyone dealing with chronic pain.   In This Episode: 00:00 Introduction to Inflammation and BPC 03:23 Dr. Jocker's Personal Experience with BPC 157 04:33 Interview with Dr. Rob Bello: Peptides and BPC 157 04:55 The Origin and Benefits of BPC 157 09:48 BPC 157: Mechanisms and Healing Properties 20:14 BPC 157: Dosage and Administration 28:00 Understanding Lip Polysaccharides and Inflammation 28:23 Why Most New Year's Resolutions Fail 30:24 The Role of Endotoxin Labs in Autoimmune Treatment 31:30 Exploring TB 500 and Its Benefits 37:21 The Wolverine Stack: Enhancing Healing and Recovery 46:41 Ensuring Quality and Efficacy in Supplements 51:29 Conclusion and Final Thoughts     Support your heart, brain, and immune system with Paleo Valley's Wild Caught Fish Roe, a whole food source rich in Omega-3s like EPA and DHA. It's more bioavailable and stable than traditional fish oil, offering benefits for cardiovascular health, mood, and brain function. Go to paleovalley.com/jockers for 15% off your order!   Looking to boost your digestion, immunity, and energy? Just Thrive Probiotic is the answer! Unlike most probiotics that get destroyed by stomach acid, Just Thrive is clinically proven to reach your gut 100% alive. This means better digestion, improved immunity, enhanced energy, and easier weight management. Plus, with their industry-leading 100% money-back guarantee, you've got nothing to lose. Start feeling your best today, go to justthrivehealth.com and use code JOCKERS to save 20%.   Turn on your body's ability to heal with Vibrant Blue Oils, particularly their parasympathetic blend. These natural essential oils activate your nervous system, reduce inflammation, enhance digestion, detoxification, and improve brain function. Visit vibrantblueoils.com/jockers to grab a $15 full-size bottle of their Parasympathetic Blend today!"       "BPC-157 doesn't block inflammation. It empowers the healing process by regulating inflammation where it's needed." ~ Dr. Jockers     Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio     Resources: Get 15% off Paleovalley Fish Roe: paleovalley.com/jockers – Use code JOCKERS Save 20% on Just Thrive: justthrivehealth.com – Use code JOCKERS Visit vibrantblueoils.com/jockers and save $15 on a full-size bottle today!       Connect with Dr. Rob Bello: Website: https://bellofamilychiropractic.com/   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/ If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

N-acetylcysteine, or NAC, plays an important role in the body when it comes to combating oxidative stress. As a precursor to make glutathione, NAC has been used for decades both as an acute medication and as an over-the-counter supplement. Recently, the line between medication and supplement has been blurred and is now being debated. Today we talk all about N-acetylcysteine - the ways NAC is used and its importance in health and disease. Today on The Lab Report: 2:45 NAC as a drug in acute care settings 4:00 Mechanisms of action in the lung and kidney 7:15 NAC as a daily supplement 10:00 Hmmm…so is it a medication or a supplement? 11:15 Generic drug or herbal constituent? 15:00 Research on NAC in psychiatric disorders 16:16 NAC in polycystic ovary syndrome and fertility 17:40 Safety and side effects 18:50 Question of the Day: What are the other precursors to glutathione and how do we measure them? Subscribe, Rate, & Review The Lab Report Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net. And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing. Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests. See omnystudio.com/listener for privacy information.

Erica and Sen welcome Sarah Shipp, guest host of the Thinking Beyond Mechanisms segment, to give her take on how we can combat anti-intellectualism using games with intentional design. Sarah has started to provide transcripts for her segment on her blog, available at https://shippboardgames.blogspot.com   

In this episode, I'm thrilled to welcome back Dr. Aaron Boster, a renowned MS neurologist, to dive deep into MS nerve pain and the impact of menopause on multiple sclerosis. We break down the different types of MS pain, including neuropathic pain, the infamous “MS hug,” and even symptoms like pathologic itching and formication. Dr. Boster also shares expert strategies and treatment options for managing MS nerve pain, including physical therapy, medications, topical creams, and non-pharmacological approaches. Plus, we discuss how hormonal changes during menopause can influence MS symptoms and progression, and what MS warriors need to know about hormone therapy. This episode offers actionable tips, practical advice, and hope for those navigating pain and menopause with MS. Whether you're looking for ways to reduce pain, manage menopause symptoms, or improve your quality of life with MS, you'll find valuable insights here! Resources mentioned in this episode: The MSing Link Episode 10, Live Your Life, Not Your Diagnosis with Dr. Aaron Boster - Apple Podcast || Spotify The MSing Link Episode 33, MS Neurology Assessment with Dr. Boster - Apple Podcast || Spotify The MSing Link Episode 34, Sexual & Bladder Dysfunction with Dr. Boster - Apple Podcast || Spotify The MSing Link Episode 233, Dr. Boster's 5 for 5 MS Management Framework: Evidence-Based Strategies to Slow Multiple Sclerosis Progression - Apple Podcast || Spotify Connect with Dr. Aaron Boster: Twitter: https://twitter.com/aaronbostermd Youtube: https://www.youtube.com/c/AaronBosterMD Facebook: https://www.facebook.com/AaronBosterMD/ Website: https://bosterms.com/ Additional Resources: https://www.doctorgretchenhawley.com/insider Reach out to Me: hello@doctorgretchenhawley.com Website: www.MSingLink.com Social: ★ Facebook: https://www.facebook.com/groups/mswellness ★ Instagram: https://www.instagram.com/doctor.gretchen ★ YouTube: https://www.youtube.com/c/doctorgretchenhawley?sub_confirmation=1 → Game Changers Course: https://www.doctorgretchenhawley.com/GameChangersCourse → Total Core Program: https://www.doctorgretchenhawley.com/TotalCoreProgram → The MSing Link: https://www.doctorgretchenhawley.com/TheMSingLink

Story at-a-glance For a century, ultraviolet blood irradiation (UVBI) has demonstrated incredible efficacy across a wide range of conditions in hundreds of studies Conditions UVBI is proven to treat include life-threatening infections, cardiovascular disorders, autoimmune conditions, and neurological issues Because of this, private doctors frequently find great success using UVBI for chronic infections (e.g., Lyme disease, shingles, or Epstein-Barr), a wide range of autoimmune diseases, and in preventing chemotherapy toxicity These results suggest UVBI can address the root cause of illness and that sunlight is an essential nutrient for the body Mechanisms identified for UVBI include it modulating the immune system, improving circulation, reactivating dormant cells, and neutralizing toxins

Erica and Sen welcome Sarah Shipp, guest host of the Thinking Beyond Mechanisms segment, to discuss cognitive load and addressing the impact of it through intentional design. Read Ludology co-founder Geoff Engelstein's article on the subject that Sarah refers to here: https://gametek.substack.com/p/grand-unified-gateway-theory

#DivideAndConquer  #WarOfPerception #ChaosBlindsTruth Bards Nation Health Store: https://www.bardsnationhealth.com BIRCH GOLD Infokit:  >>>Text BARDS to 989898 MYPillow promo code: BARDS Go to https://www.mypillow.com/bards and use the promo code BARDS or... Call 1-800-975-2939.  Support Pete Chambers Team: https://theremnantministrytx.org WNC Mountain Ops: https://baldguybrew.com Founders Bible 20% discount code: BARDS >>> https://thefoundersbible.com/#ordernow Mission Darkness Faraday Bags and RF Shielding. Promo code BARDS: Click here EMPShield protect your vehicles and home. Promo code BARDS: Click here EMF Solutions to keep your home safe: https://www.emfsol.com/?aff=bards Treadlite Broadforks...best garden tool EVER. Promo code BARDS: Click here DONATE: https://store.bardsnation.com/donate/ Mailing Address: Xpedition Cafe Attn. Scott Kesterson 591 E Central Ave, #740 Sutherlin, OR  97479