Podcasts about mechanisms

In this episode of Daily Value, we look into the synergistic relationship between two nutrient classes in supporting brain health and mitigating cognitive decline. Drawing on evidence from past clinical evidence suggesting these two nutrient classes work in tandem to support brain function and health.Discussion Points:-Homocysteine's role in disrupting fatty acid incorporation into cell membranes and amyloid-beta clearance.-Findings from one study, where some 70-year-old participants experienced up to 30% reduction in brain atrophy.-Practical strategies to optimize intake of these nutrients.00:00 Introduction to Brain Health and Nutrition01:06 Understanding Mild Cognitive Impairment01:44 The Role of B Vitamins and Omega-3s02:34 Mechanisms of One Carbon Metabolism03:06 Impact of Homocysteine on Brain Health04:12 Key Studies on Nutrient Synergy07:05 Practical Dietary Recommendations08:07 Conclusion and Final Thoughtshttps://pubmed.ncbi.nlm.nih.gov/22260268/https://pubmed.ncbi.nlm.nih.gov/29480200/https://pubmed.ncbi.nlm.nih.gov/26757190/Support the show

Erica and Sen welcome Sarah Shipp, guest host of the Thinking Beyond Mechanisms segment, to discuss how designers might approach the dreaded human factor we call "Analysis Paralysis" or AP.

In episode #166 of the PricePlow Podcast, Mike and Ben welcome Ed Dosz, VP of Science Innovation at NutriScience Innovations, to discuss MalTor, a groundbreaking ingredient that combines taurine and L-malic acid in a patent-pending complex. With his Ph.D. in food science and extensive background at NOW Foods, Ed brings deep scientific expertise to the conversation about this novel recovery-enhancing and mitochondria-supporting ingredient. Ed Dosz & NutriScience's MalTor: Revolutionizing Recovery Through Mitochondrial Support The discussion explores MalTor's development journey from initial concept to clinical validation, highlighting how this uniquely-complexed ingredient improves upon the individual benefits of taurine and L-malic acid. Ed explains the rigorous research process behind MalTor, including preclinical nematode studies and human clinical research conducted by Dr. Jose Antonio showing significant benefits for muscle recovery and pain threshold management after intense exercise. Beyond recovery applications, the conversation ventures into MalTor's potential for healthy aging, sports nutrition formulations, and synergistic combinations with other ingredients like citrulline. The episode also features an enlightening tangent into Ed's background as the “Broccoli Guy,” where he shares fascinating insights about sulforaphane and optimal cooking methods to preserve broccoli's bioactive compounds. Subscribe to the PricePlow Podcast for more conversations with industry insiders on breakthrough ingredients and the science behind effective supplementation! https://blog.priceplow.com/podcast/podcast/nutriscience-maltor-ed-dosz-166 Video: Ed Dosz Explains NutriScience's MalTor – Taurine & Malic Acid Complexed https://www.youtube.com/watch?v=jC7JzhKaEgA Detailed Show Notes: The Science Behind MalTor with Ed Dosz (0:00) – Introduction and Ed's Scientific Background (4:15) – NutriScience Innovations: Company Overview and Philosophy (11:45) – The Development of MalTor: From Concept to Finished Ingredient (19:00) – The Scientific Rationale Behind MalTor (24:30) – Research Methods: From Nematodes to Human Studies (33:40) – Human Clinical Research on MalTor (38:00) – Recovery Applications and Mechanisms (42:00) – Formulation Applications and Synergies (44:15) – Additional Product Formats and Applications (48:45) – Healthy Aging Applications for MalTor (53:00) – Additional Ingredient Combinations for Healthy Aging (55:00) – The “Broccoli Guy”: Ed's Research on Sulforaphane (1:04:00) – Closing Thoughts and Contact Information Where to Find Ed Dosz and Learn More About MalTor NutriScience Innovations: NutriScienceUSA.com (track news on PricePlow.com/nutriscience NutriScience on LinkedIn: LinkedIn.com/company/nutriscience-innovations-llc/ Ed Dosz on LinkedIn: LinkedIn.com/in/edward-dosz/ MalTor Breakdown Article:… Read more on the PricePlow Blog

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page.  Mind Pump Fit Tip: The 5 best diets for ANY goal. (1:38) The MOST common mistake people make with fitness & diet. (19:53) The BEST recovery tool to manage stress. (31:03) Terrible/harming tactics by mainstream media. (35:27) Creatine and depression. (41:27) The history of ginseng. (44:12) The conspiracy theory behind art. (48:36) Kids say the darndest things. (53:12) Mind Pump Recommends You Can't Ask That on Netflix. (56:21) Train the Trainer 3-Part Bonus Series dropping May 19th! (1:00:47) #Quah question #1 – What do you guys do to keep up strength when resting an injury? (1:01:37) #Quah question #2 – What should you do if you are reverse dieting but see weight gain? (1:04:17) #Quah question #3 – Will taking NSAID's to treat an acute injury completely negate gains from strength training? (1:06:04) #Quah question #4 – How do you see AI affecting the fitness industry? What are the pros and cons that can come of its involvement for trainers, nutrition coaches and their clients? (1:09:26) Related Links/Products Mentioned Visit Eight Sleep for an exclusive offer for Mind Pump Listeners! ** Use the code MINDPUMP to get $350 off your very own Pod 5 Ultra. The best part is that you still get 30 days to try it at home and return it if you don't like it - - Shipping to many countries worldwide. ** Visit Joy Mode for an exclusive offer for Mind Pump listeners! ** Enter MINDPUMP at checkout for 20% off your first order. ** May Special: MAPS 15 Performance or RGB Bundle 50% off! ** Code MAY50 at checkout ** Labs - Stephen Cabral Why Are Americans So Obsessed With Protein? Blame MAGA Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions Mind Pump #2530: Why All Women Should Take Creatine The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE) Watch You Can't Ask That - Netflix Train the Trainer Webinar Series – 3 Part Bonus Series  Visit Hiya for an exclusive offer for Mind Pump listeners! ** Receive 50% off your first order ** Mechanisms and applications of the anti-inflammatory effects of photobiomodulation Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Mikhaila Peterson (@mikhailapeterson) Instagram Dr. Stephen Cabral (@stephencabral) Instagram Benjamin Bikman (@benbikmanphd) Instagram  

Send us a textJohn Martell is a multifaceted mechanical engineer whose career bridges the worlds of aerospace, product development, and geospatial drone services. With over 14 years of industry experience, John has worn many hats—from designing guided-parafoil airdrop systems and reverse-engineering medical devices to leading multi-disciplinary engineering teams on complex automation and packaging systems. He currently serves as the Director of Data Management at Aero Velocity, where he combines his technical acumen with data tools like QGIS, Python, and LP360 to manage large-scale geospatial projects.Prior to his current role, John was a Lead Mechanical Engineer at Workhorse Aero, where he contributed significantly to drone and aerospace innovations. Earlier in his career, he spent several years at Pipeline Design & Engineering, where his talent for building repeatable test fixtures and automation for medical device applications set new benchmarks in performance and reliability. His work there earned him a reputation as one of the company's best engineers—a sentiment echoed by Pipeline's leadership.What sets John apart isn't just his technical expertise but also his passion for creative problem-solving and his continuous drive to learn. He's a tinkerer at heart with a flair for optimization, whether it's improving internal engineering processes through custom macros or exploring new technologies in CAD and product testing. He's also the musical mind behind the intro and outro of the Being an Engineer podcast, creating music under the name “Olivund.”With his unique combination of technical depth, leadership, and artistic creativity, John Martell exemplifies what it means to be a modern, versatile engineer.LINKS:https://www.linkedin.com/in/john-martell/https://507movements.com/ Aaron Moncur, host

Joe sits down with Christian Drapeau, a stem cell expert with over 20 years of research under his belt, to talk about how the body repairs itself, and how we can help it do a better job. They get into what stem cells actually do, why we lose them as we age, and how that affects recovery, energy, and long-term health. Christian shares simple, natural ways to support stem cell activity, like fasting, exercise, and plant-based supplements. They also talk about stem cell therapies and how they compare to everyday strategies you can use to support your body's natural repair system.- Check out SelfDecode: https://selfdecode.com/- Join Joe's online community: https://thejoecohenshow.com/Timestamps: (00:00) Introduction to the Joe Cohen Show(00:17) Meet Christian Drapeau(01:14) Understanding Stem Cells and Their Benefits(02:00) Natural Ways to Increase Stem Cells(06:44) Stem Cells and Longevity(12:19) Stem Cell Supplements vs. Injections(23:42) Hyperbaric Chambers and Stem Cells(25:32) Understanding Hyperbaric Chambers(26:45) Introduction to Stem Cell Enhancing Plants(27:13) Top Plants for Increasing Stem Cells(28:00) Mechanisms and Effects of Specific Plants(32:45) Combining Plants for Optimal Stem Cell Release(34:35) Active Compounds in Stem Cell Enhancing Plants(41:59) Stem Cell Supplements and Their Benefits(46:08) Conclusion and Further Resources

In this episode of Daily Value, we look at a forgotten compound found in common vegetables such as kale, spinach, and broccoli. Discovered in the 1930s and initially thought to be a vitamin (dubbed “Vitamin P”), this compound has recently demonstrated significant potential in neuroprotection.This compound may soon become an essential component in neuroprotective and longevity formulations.00:00 Introduction to Brain Health Molecules00:19 The Forgotten Flavonoid01:08 Historical Background01:59 Neuroprotective Properties02:51 Mechanisms of Action in Brain Health03:34 Recent Research and Findings05:25 Broader Implications and Applications06:48 Challenges and Future Directions07:24 Conclusion and Final Thoughtshttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-025-01927-yhttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.565700/fullhttps://www.sciencedirect.com/science/article/pii/S0753332223010065Support the show

In this episode of Better Thinking, Nesh Nikolic speaks with Dr. Zhi Yi Ong about the neurobiology of food intake, exploring how gut-brain interactions shape eating behavior and its connection to addiction. Zhi Yi Ong is a Senior Lecturer and ARC Future Fellow at the UNSW School of Psychology. She completed her PhD in Biomedical Science at the University of South Australia and later undertook postdoctoral training in the Department of Psychology at the University of Pennsylvania. Zhi Yi's research focuses on the neurobiological mechanisms of feeding behaviors. Using multiple neuroscience approaches in animal models, she investigates how gut signals interact with brain circuits to regulate these behaviors. Additionally, she also examines how environmental factors and current treatments influence the neural systems that control appetite. Episode link at See omnystudio.com/listener for privacy information.

In this episode, we sit down with Rob Fried, an Academy Award and Emmy Award-winning motion picture producer and, since 2018, the CEO of ChromaDex. Although he has interests in media and business, Rob also has an immense passion for health and wellness – specifically, the science of anti-aging… ChromaDex is a global bioscience company dedicated to healthy aging. Their team comprises world-renowned scientists pioneering research on nicotinamide adenine dinucleotide (NAD+), a coenzyme critical to metabolism health that declines with age. By creating a breakthrough ingredient commercially known as Niagen®, Rob and his team have one central goal to fulfill: To help the world age better. Join us now to discover: The best ways to elevate your NAD+ levels. How to improve the body's ability to manufacture energy. Mechanisms that contribute to the production of NAD+. Common mitochondrial dysfunctions that can cause fatigue. To learn more about Rob and his work with ChromaDex, click here! Episode also available on Apple Podcast: http://apple.co/30PvU9C

Dietitians, Leah Heigl & Aidan Muir, explore the effects of alcohol on muscle growth and recovery. They discuss the overall mechanisms that may impact it, and what the overall impact is according to the research.    (0:00) - Introduction (0:34) - Mechanisms (1:43) - Study 1: MPS Difference from Protein vs Protein + 12 Standard Drinks (3:55) - Study 2: Recovery Differences from Placebo vs 10 Standard Drinks (5:58) - Study 3: Systematic Review: Impact on MPS from Alcohol (7:04) - Our Thoughts & Practical Takeaway     WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en   Our dietitians

Is free will limited or unlimited? What is the scope of free will? How much of our decisions must filter through that system of choice? How much can we actually accomplish if we set our mind to it? What is the mechanisms of ascending a free will ladder? In part 2 of our study of […]

If you want to slow your rate of aging or even reverse it - you'll need to know these 12 mechanisms of aging...and it's not what you think.  NOVOS not only makes products that address each of these mechanisms, they also will provide you with a biological assessment that is more accurate than any other in the world.  Check NOVOS our HERE ----> and use OPP for a discount! Find OPP episodes, discounts on products, learn about my Life Coaching and Performance Coaching work at Seanmccormick.com and hit me up sean@seanmccormick.com 01:28 Chris's Health Journey and Transformation 04:47 Understanding Aging and Longevity 08:55 Realistic Perspectives on Lifespan and Healthspan 10:53 The Science Behind NOVOS Age Test 19:31 The 12 Mechanisms of Aging 30:25 Understanding Cellular Communication and Aging 31:16 Debunking Longevity Supplements 34:38 The Science Behind Longevity Supplements 36:57 The Role of Lithium in Longevity 40:57 Ensuring Ingredient Purity and Safety 43:51 Customer Feedback and Product Efficacy 48:32 The Future of Longevity and Health 56:43 Empowering Through Knowledge and Technology

Is free will limited or unlimited? What is the scope of free will? How much of our decisions must filter through that system of choice? How much can we actually accomplish if we set our mind to it? What is the mechanisms of ascending a free will ladder? In part 2 of our study of free will, we continue our exploration of fundamental concepts in free will, and learn about the transformative insight of the point of free will conflict.– – – – – – – – – – – – – – – – – – – – – –DONATE to TORCH: Please consider supporting the podcasts by making a donation to help fund our Jewish outreach and educational efforts at https://www.torchweb.org/support.php. Thank you!– – – – – – – – – – – – – – – – – – – – – –Email me with questions, comments, and feedback: rabbiwolbe@gmail.com– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to my Newsletterrabbiwolbe.com/newsletter– – – – – – – – – – – – – – – – – – – – – –SUBSCRIBE to Rabbi Yaakov Wolbe's PodcastsThe Parsha PodcastThe Jewish History PodcastThe Mitzvah Podcast This Jewish LifeThe Ethics PodcastTORAH 101 ★ Support this podcast ★

In this episode, Guy spoke with Dennis McKenna, a respected ethnopharmacologist, discussed the nature of reality and consciousness, and how they are shaped by our brain's neurochemistry. He elaborated on the role of psychedelics in expanding consciousness and their therapeutic applications in mental health. McKenna also reflected on his career, significant influences, and the development of ethnopharmacology as a field. He touched on his brother Terence McKenna's impact, shared personal anecdotes, and shedded light on the McKenna Academy's mission. The conversation delved into the importance of safe and informed use of psychedelics and emphasizes curiosity, open-mindedness, and the pursuit of understanding in exploring the mind and consciousness. About Dennis: Dennis McKenna has conducted research in ethnopharmacology for over 40 years.  He is a founding board member of the Heffter Research Institute, and was a key investigator on the Hoasca Project, the first biomedical investigation of ayahuasca.  He is the younger brother of Terence McKenna.  From 2000 to 2017, he taught courses on Ethnopharmacology and Plants in Human affairs as an adjunct Assistant Professor in the Center for Spirituality and Healing at the University of Minnesota. Key Points Discussed:  (00:00) - It's a SIMULATION! Psychedelics, Consciousness, and the Reality You're Not Seeing (00:55) - Podcast Announcement and Engagement (01:37) - Guest Introduction: Dennis McKenna (03:00) - Defining Ethnopharmacology (05:48) - The 2017 Conference and Its Significance (10:10) - The Influence of Early Books on Psychedelics (13:02) - Understanding Psychedelics and Their Impact (18:14) - The Therapeutic Potential of Psychedelics (21:26) - Personal Experiences with Ayahuasca (23:22) - Exploring Consciousness and Reality (30:36) - Understanding the Default Mode Network (31:07) - Therapeutic Benefits of Psychedelics (34:34) - Exploring Different Psychedelics (35:50) - Mechanisms of MDMA and SSRIs (37:29) - Alternative Psychoactive Substances (38:53) - Resources for Learning About Psychedelics (44:30) - The McKenna Academy and Its Mission (49:34) - Personal Reflections and Insights (54:51) - Recommended Resources and Final Thoughts How to Contact Dennis McKenna:mckenna.academy About me:My Instagram: www.instagram.com/guyhlawrence/?hl=en Guy's websites:www.guylawrence.com.au www.liveinflow.co''

How could a single psychedelic treatment cause lasting change? Joshua Siegel, MD, PhD, is on a mission to find out. A leading expert on neuroimaging and neuropsychopharmacology at NYU Langone's Center for Psychedelic Medicine, Dr. Siegel unpacks how psilocybin may spark neuroplasticity and reshape the depressed brain. He also gives us an inside look at the race to develop non-hallucinogenic psychedelic analogs. Dr. Siegel is an assistant professor at NYU Grossman School of Medicine.

In this episode of Passing Judgment, host Jessica Levinson speaks with NPR's Elissa Nadworny to unpack the Trump administration's efforts to withhold federal funding from colleges and universities over issues like antisemitism and DEI practices. They discuss how these unprecedented moves are impacting not campus life, but vital medical and scientific research nationwide. Elissa explains the legal challenges schools like Harvard are mounting in response, the stakes involved for the entire higher education sector, and the broader implications for public policy.Here are three key takeaways you don't want to miss:Federal Funding as a Lever in Higher Education Policy: The episode opens by surveying recent actions from the Trump administration regarding federal funding for colleges and universities. The administration is using financial levers—pausing, freezing, or cutting funds—to influence policies on campus, particularly tied to issues like DEI (diversity, equity, and inclusion) and antisemitism. Mechanisms and Legality of Federal Control: The speakers discuss how and why the administration has the power to control this funding. The complexities of federal funding—who controls the purse strings, when Congress vs. the executive branch has authority, and what legal mechanisms are at play—come up. The episode highlights that while presidents can make funding conditional, the legality often hinges on whether proper procedures are followed (Administrative Procedures Act), not just on broad authority.Who Really Loses When Funds Are Cut: The speakers emphasize that federal research dollars are not just about student amenities—they fund major scientific, medical, and technological research. The implications of large-scale cuts ripple well beyond campuses, potentially hurting national health, technological innovation, and local economies (since universities are major employers and research hubs).Follow Our Host: @LevinsonJessica

Jake Palumbo discusses the intersection of mental health and music, exploring themes of healing, grief, and the importance of therapy. He shares personal experiences with loss, panic attacks, and the challenges of isolation, while also emphasizing the value of coping mechanisms and the therapeutic process. The discussion culminates in insights about his upcoming album, 'Euthanasia for the Stupid', which aims to address societal issues through a lens of humor and critique.Chapters (00:00) Introduction to Mental Health and Music(03:38) The Concept of Violence in Healing(06:33) Personal Struggles and the Impact of Loss(09:45) The Double Life of Public Success and Private Pain(12:46) The Importance of Therapy and Professional Help(15:32) Navigating Vulnerability in Music(18:42) Experiencing Panic Attacks and Anxiety(21:31) The Role of Friends and Family in Mental Health(24:41) Confronting Trauma and Finding Healing(35:41) Experiencing Anxiety and Panic Attacks(44:55) The Struggles with Medication and Mental Health(51:46) Coping Mechanisms and Creative Outlets(01:02:59) Navigating Grief and Loss(01:04:17) Upcoming Projects and Artistic DirectionJake Palumbo Links:Instagram: https://www.instagram.com/jakepalumbo/Spotify: https://open.spotify.com/artist/1LAjUUeNbeMzDC3EzSZbw3?si=Z2-2oCfTSk-FxRUfl4vGfwBandcamp: https://spacelabrecordings.bandcamp.com/Website: https://jakepalumbo.com/Follow Me on Social Media:https://www.instagram.com/thevoncastshow/https://www.instagram.com/shibavon/ https://www.iamvon.net/

In this podcast, Dr. Valentin Fuster explores a study on the effects of SGLT2 inhibitors, like empagliflozin, on erythropoiesis and iron mobilization in heart failure patients. The research reveals how these drugs activate key metabolic pathways, potentially enhancing iron utilization and improving clinical outcomes, with significant implications for treatment in heart failure and chronic kidney disease.

Comments or feedback? Send us a text! Dr. Chris Taplin,a psychiatrist and founder of Ottawa's TMS Life clinic, joins us for a deep dive into one of the most promising frontiers in psychiatric care: Transcranial Magnetic Stimulation, or TMS. As clinicians, many of us have encountered the heartbreak of treatment-resistant depression — watching clients struggle despite best-practice psychotherapy and pharmacology. TMS offers a non-invasive, evidence-based alternative that is reshaping how we approach these cases. In this conversation, we unpack the science, patient experience, clinical decision-making, and broader implications of this technology. Whether you're a skeptic, a curious clinician, or already working with neuromodulation, I think you'll find this a thoughtful, grounded look at where TMS fits in the future of mental health treatment.Topics We Cover:

In this episode, Catherine Fahey, MD, PhD; Alexandra Leary, MD, PhD; Funda Meric-Bernstam, MD; and Zev A. Wainberg, MD, explore the mechanisms of HER2-targeted antibody–drug conjugates (ADCs) and emerging clinical data with these agents across genitourinary, gastrointestinal, and gynecologic cancers.Mechanisms of action of ADCs: how ADCs selectively deliver potent chemotherapy to tumor cellsClinical data across tumor types: highlights from recent trials with trastuzumab deruxtecan and exploration of emerging data on agents such as disitamab vedotinChallenges and future directions:key considerations for combining HER2-targeted ADCs with immunotherapy or chemotherapy, and sequencing ADC therapiesPresenters:Catherine Fahey, MD, PhDAssistant ProfessorDivision of OncologyUniversity of North Carolina at Chapel HillChapel Hill, North CarolinaAlexandra Leary, MD, PhDPresident, GINECO GroupCo-Director, Department of Medical OncologyMedical Oncologist GynecologyTeam Leader, Gynecologic Translational Research Lab, INSERM u981Institut Gustave RoussyVillejuif, FranceFunda Meric-Bernstam, MDChair, Department of Investigational Cancer TherapeuticsMedical Director, Institute for Personalized Cancer TherapyNellie B. Connally Chair in Breast CancerThe University of Texas MD Anderson Cancer CenterHouston, TexasZev A. Wainberg, MDProfessor of Medicine and SurgeryCo-Director of GI OncologyDirector, Early Phase Clinical Research ProgramJonsson Comprehensive Cancer CenterUCLA School of MedicineLos Angeles, CaliforniaLink to full program:https://bit.ly/42iEDjVTo claim credit for listening to this episode, please visit the podcast online at the link above. 

Send me a DM here (it doesn't let me respond), OR email me: imagineabetterworld2020@gmail.comI'm honored to have back on the show: ritual abuse, child trafficking, and governmental mind control survivor, overcomer, and whistleblower, loving mother, artist and visionary, entrepreneur, podcast host and creator of her own incredible, educational and informative YouTube channel @Desert Dakini, podcast regular and one of our most beloved and requested guests, and my dear friend - Carrie Olaje!In case you're new here or missed any of Carrie's incredible episodes where she walks us through her harrowing and inspiring testimony - here's a short recap: Carrie was born into a multi-generational incest-based family and from a young age was sold into government-sponsored child slavery and behavioral modification programs with the goal of making her a child assassin, sex slave, channeler, and ritual butcher. Her abuse was perpetuated initially by her father who then passed her on to other owners and handlers who furthered her programming, trafficking and ritual abuse. I encourage you all to go watch the important testimony we did on our first episode together as Carrie quite literally paints us some massive disclosures that give deeper insights into the operational and orchestrated aspects of satanic rituals and abuses that happen within these occult networks. Words fall short of capturing the profound privilege of hosting Carrie on this platform. Her fearless, raw, and unfiltered storytelling - woven with artistry and authenticity—delivers testimony, wisdom, and guidance that resonate with staggering impact. Carrie's podcast episodes are nothing short of groundbreaking, plunging into the depths of her lived experience: a reality so unimaginable, so incomprehensible, that it defies belief for most. Yet, through her vivid narratives and breathtaking art, she transforms the unspeakable - some of history's most heinous crimes against humanity - into visceral, undeniable truth. Her paintings, each a masterpiece of pain and beauty, amplify her voice, showcasing a rare talent that makes the invisible starkly real.Carrie's vulnerability is her superpower. By baring her soul, she has crafted some of the most transformative testimony ever shared, touching hearts, awakening souls, and leaving an unforgettable mark on every listener. Her episodes are a lifeline, offering hope, validation, and education to those who hang on her every word. I am endlessly grateful that Carrie has chosen this platform as a sacred space to revisit, sharing her journey and illuminating paths to healing. Today - in typical Carrie fashion - we venture into bold new territory, building on the foundations we've built on the topics of organized abuse. Carrie will unravel the mechanisms of programming, offering critical context for healing and system work. She'll dive deeper into the shadowy worlds of ritual abuse, governmental, and military mind control - equipping us with knowledge to confront these horrors. CONNECT WITH CARRIE: YouTube: @carrieolaje CONNECT WITH THE IMAGINATION:EMAIL: imagineabetterworld2020@gmail.comMy Substack: https://emmakatherine.substack.com/BUY ME A COFFEE: https://www.buymeacoffee.com/theimaginationAll links: https://direct.me/theimaginationpodcastRIFE TECHNOLOGIES:https://realrifetechnology.com/15% Code: 420CZTL METHELENE BLUE:https://cztl.bz?ref=Support the show

In this Beekeeping Today Podcast Short, Dr. Dewey Caron returns with an “audio postcard” on one of spring's biggest challenges: swarming. In less than 20 minutes, Dewey breaks down the science and management strategies of swarming across three communication levels—bee scientist to beekeeper, beekeeper to bees, and bee to bee. Dewey emphasizes that successful beekeeping often hinges on managing three core issues: overwintering, varroa control, and swarming. Drawing from scientific literature, field experience, and behavioral cues, he details proactive and reactive swarm management practices—from requeening and early supering to Demaree splits, Snelgrove boards, and shook swarms. He also explores the signals bees send each other—pheromones, body heat, piping calls, and buzz running—that guide the colony toward swarming and relocation. If you're looking to better understand how to read your bees this spring and respond before the swarm takes flight, this episode is packed with insights you can put to work in your own apiary. Links & Resources: Honey Bee Obscura Podcast with Dr. Jim Tew: https://honeybeeobscura.com Research Paper, "From Molecules to Societies:..":  https://www.researchgate.net/publication/271913315_From_molecules_to_societies_Mechanisms_regulating_swarming_behavior_in_honey_bees_Apis_spp [accessed Apr 06 2025] Tom Seeley's Latest Book: Seeley, Thomas D. 2024. Piping Hot Bees & Boisterous Buzz Runners. Princeton Univ Press   Brought to you by Betterbee – your partners in better beekeeping. ______________ Betterbee is the presenting sponsor of Beekeeping Today Podcast. Betterbee's mission is to support every beekeeper with excellent customer service, continued education and quality equipment. From their colorful and informative catalog to their support of beekeeper educational activities, including this podcast series, Betterbee truly is Beekeepers Serving Beekeepers. See for yourself at www.betterbee.com Copyright © 2025 by Growing Planet Media, LLC

Von shares his personal journey with ADHD, discussing the importance of therapy, the challenges of impulsivity, and the impact of his diagnosis on his self-esteem. He reflects on coping mechanisms, including video games, and emphasizes the need for accessible mental health resources. Von also addresses the complexities of managing ADHD without medication and encourages listeners to seek help when needed.Chapters (00:00) Introduction and Personal Update(03:49) The Importance of Therapy(06:30) Understanding ADHD (09:37) Impulsivity and Addiction(12:49) Self-Discovery and Relief(15:38) Navigating Impulse Control(18:33) Coping Mechanisms and Video Games(21:25) Managing ADHD Without Medication(29:29) Conclusion and Final ThoughtsFollow Me on Social Media:https://www.instagram.com/thevoncastshow/https://www.instagram.com/shibavon/ https://www.iamvon.net/

Drs Carol H. Wysham and Christopher M. Kramer discuss heart failure and type 2 diabetes, and the role of incretin therapies in the management of HFpEF. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/1002048. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources The Incidence of Congestive Heart Failure in Type 2 Diabetes: An Update https://pubmed.ncbi.nlm.nih.gov/15277411/ Hypertension in Diabetes: An Update of Basic Mechanisms and Clinical Disease https://pubmed.ncbi.nlm.nih.gov/34601960/ Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America: This statement does not represent an update of the 2017 ACC/AHA/HFSA heart failure guideline update https://pubmed.ncbi.nlm.nih.gov/31167558/ Insulin Resistance and Hyperinsulinaemia in Diabetic Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/26678809/ Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2024 https://pubmed.ncbi.nlm.nih.gov/38078592/ The Paradox of Low BNP Levels in Obesity https://pubmed.ncbi.nlm.nih.gov/21523383 Tirzepatide for Heart Failure With Preserved Ejection Fraction and Obesity https://pubmed.ncbi.nlm.nih.gov/39555826/ Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials https://pubmed.ncbi.nlm.nih.gov/35050311/ Beyond Weight Loss: the Emerging Role of Incretin-Based Treatments in Cardiometabolic HFpEF https://pubmed.ncbi.nlm.nih.gov/38294187/ Heart Failure With Preserved Ejection Fraction: Mechanisms and Treatment Strategies https://pubmed.ncbi.nlm.nih.gov/34379445/ Obesity and Heart Failure With Preserved Ejection Fraction: New Insights and Pathophysiological Targets https://pubmed.ncbi.nlm.nih.gov/35880317/ Epidemiology of Heart Failure in Diabetes: A Disease in Disguise https://pubmed.ncbi.nlm.nih.gov/38334818/ Semaglutide in Patients With Heart Failure With Preserved Ejection Fraction and Obesity https://pubmed.ncbi.nlm.nih.gov/37622681/ Mechanisms of Benefits of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Preserved Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/37674356/ Finerenone in Heart Failure With Mildly Reduced or Preserved Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/39225278/ Effects of Tirzepatide on Circulatory Overload and End-Organ Damage in Heart Failure With Preserved Ejection Fraction and Obesity: A Secondary Analysis of the SUMMIT Trial https://pubmed.ncbi.nlm.nih.gov/39551891/ Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, a Preserved Ejection Fraction, and Obesity https://pubmed.ncbi.nlm.nih.gov/39556714/ Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy https://pubmed.ncbi.nlm.nih.gov/39566869/6 Spironolactone for Heart Failure With Preserved Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/24716680/

Original Post

Could ketogenic therapy change the future of autism spectrum disorder (ASD) treatment?The CDC estimates that 1 in 36 children are affected by ASD but due to the wide variety of signs and symptoms associated, it's likely that this doesn't account for everyone impacted. And treatment options are scarce and vary in effectiveness.In this video, Dr. Bret Scher sits down with Dr. Eline Dekeyster, Assistant Professor at Leiden University and Head of the Lifestyle Brain Interaction research group, to explore how nutritional ketosis may support individuals with autism and other brain-based conditions.Dr. Dekeyster brings a rare blend of personal insight and scientific expertise. She opens up about her own experience with mood disorders and how ketosis helped shift her mental energy, leading her to dedicate her research to metabolic psychiatry.In this episode, you'll learn about:The early but promising evidence supporting ketogenic therapy in autism spectrum disorderThe metabolic and neurological mechanisms involvedA real-life case of a child with ASD whose symptoms improved on a ketogenic diet and the troubling response from the medical systemThe challenges and strategies around adherence to ketogenic interventions in neurodivergent populationsDr. Dekeyster's vision for a collaborative, individualized care model that includes dietary, medical, and emotional supportWhile more research is needed to fully understand the impact of nutritional therapies for autism spectrum disorder, ketogenic therapy may offer meaningful hope to individuals and families navigating the challenges of ASD today.Expert Featured:Dr. Eline Dekeysterhttps://www.instagram.com/lbi.research/CMEs Mentioned:Managing Major Mental Illness with Dietary Change: The New Science of Hopehttps://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616Brain Energy: The Metabolic Theory of Mental Illnesshttps://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

In this episode, we explore the critical role of serotonin in shaping sensory maps within the brain, a process vital for interpreting sensory input and navigating the world. Serotonin, a neurotransmitter and neuromodulator synthesized from the aromatic amino acid tryptophan, influences brain development by fine-tuning sensory systems. It modulates neuronal growth, synaptic connections, and plasticity, which are essential for creating accurate sensory maps in regions like the somatosensory cortex, visual cortex, and auditory cortex. These maps serve as blueprints for processing touch, vision, and sound, with serotonin regulating the pruning of connections in the thalamus and cortex to ensure precise sensory wiring.The episode also explores the broader biological implications of serotonin, emphasizing its role in both prenatal and postnatal development. Maternally derived serotonin, supplied via the placenta from the peripheral and enteric nervous systems, significantly influences fetal brain development, affecting proliferation, differentiation, and neuronal migration in sensory regions. Postnatally, serotonin continues to support sensory integration and mood regulation, working alongside oxytocin to facilitate bonding and stress buffering. We explore environmental factors, such as stress and modern lighting, on serotonin synthesis and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol release. Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for a 10% discount03:12, Sensory Map Introduction and Serotonin's Role, The episode introduces sensory maps, neural blueprints that help the brain interpret sensory inputs like touch, vision, and sound, 04:30, Serotonin's Developmental Impact, Serotonin fine-tunes sensory systems by modulating neuronal growth, synaptic connections, and plasticity, creating precise sensory maps in the somatosensory, visual, and auditory cortices,06:04, Serotonin and Sensory Processing (Visual), Serotonin, sensory processing in the visual cortex08:29, Critical Periods and Neuroplasticity, sensory neurons and connections, pruning10:00, Brain Regions and Serotonin's Mechanisms, Serotonin, axonal guidance, neurogenesis, and migration via microtubules, brain-derived neurotrophic factor (BDNF), glutamate and GABA12:55, Serotonin and Sensory Processing (Somatosensory),13:51, Serotonin and Sensory Processing (Auditory),14:52, Stress and the HPA Axis, Cortisol, circadian rhythms and cortisol spikes, modern environments,16:16 Daylight Computer Company, use "autism" for a $25 discount20:38, Maternal Serotonin and Prenatal Influence; Postnatal Serotonin and Oxytocin; Tryptophan Metabolism and Neurodevelopment, placenta, fetal brain development, proliferation, differentiation, and neuronal migration, serotonin, oxytocin & bonding and stress buffering, TPH1 and TPH2, kynurenine pathwayX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

In this episode, Sam presents a comprehensive overview of ketamine therapy from a clinical lens. Originally delivered as a lecture titled “Exploring Ketamine IV Infusions: A Novel Approach for Depression, PTSD, Anxiety, & Chronic Pain” to the UCLA–Betty Ford Addiction Medicine Fellowship, this session walks through everything from the mental health crisis to ketamine's evolving role in modern treatment.Whether you're a curious clinician or an experienced provider, this is your go-to primer on how ketamine therapy works—and why it matters now more than ever. With over 50 years of clinical use and a growing body of scientific research, ketamine is proving to be a powerful option for treatment-resistant depression, PTSD, anxiety, and chronic pain. Sam brings together the science, protocols, and personal insights from running a real-world ketamine clinic to help demystify the treatment process and spark deeper understanding among medical professionals.What You'll Gain From This Episode:・A deeper understanding of how ketamine works in the brain・Knowledge of current research and studies supporting ketamine's use・Insights into patient selection, safety, and personalized dosing strategiesEpisode 31 show notes:00:00 Teaser - Depression is the leading cause of disability worldwide.00:30 Welcome and Episode Overview01:17 Ketamine Infusions: A Novel Approach02:17 Current State of Mental Health and Ketamine History09:36 Mechanisms of Action and Scientific Studies12:11 Patient Experiences and Clinical Applications23:22 Ideal Patient Selection and Dosing Protocols29:10 Potential Side Effects and Addiction Risks33:21 Conclusion and Final ThoughtsThanks for listeningFor references and studies mentioned in this episode, go to www.ketaminestartup.com/podcast/episode-031Follow us onInstagramLinkedinKetamine StartUp WebsiteYouTube

Dr Deanna Minich provides a comprehensive exploration of the diverse aspects of melatonin, offering a deeper understanding of the mechanisms and benefits of this sleep-associated neurotransmitter. The discussion, hosted by fx Medicine by BioCeuticals Ambassador Dr Adrian Lopresti, covers the different types of melatonin in the body, shedding light on its production sites and widespread presence across body systems. The episode also explores the connection between melatonin and the gut, its impact on mitochondria, and provides a detailed breakdown of the six pivotal roles that melatonin plays. The conversation touches on a variety of health conditions that melatonin may support, and outlines natural ways to enhance melatonin production—starting with optimising light exposure, dietary strategies, and the potential of plant-sourced melatonin. Listeners will also gain insights into how endogenous melatonin levels vary across life stages. Importantly, the podcast addresses safety considerations, differences in regulatory status, and offers evidence-based dosage recommendations. COVERED IN THIS EPISODE (00:58) Welcoming Dr Deanna Minich (01:53) What is melatonin? (04:27) The role of melatonin in the gut (06:31) The role of melatonin in energy production (08:27) Therapeutic benefits of melatonin (10:22) Melatonin's role in ageing (11:43) Melatonin in inflammation (13:56) How light affects the production of melatonin (21:14) How diet affects the production of melatonin (29:21) Plant melatonin (31:39) Melatonin production reduction through ageing (34:34) Melatonin and the circadian rhythm (40:57) Melatonin - a molecule of consciousness (44:12) The role of stress in melatonin production (46:27) Melatonin supplementation (51:59) Melatonin dosage (55:48) Timing on supplementation for sleep (58:58) Synergystic effects of melatonin and nutritionals (01:00:49) Melatonin dosage in perimenopause (01:03:10) Thanking Dr. Minich and closing remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/melatonin-mechanisms-of-action-it-s-amazing-role-beyond-sleep-with-dr-adrian-lopresti-dr-deanna-minich Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://login.bioceuticals.com.au ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

Erica and Sen welcome Sarah Shipp, guest host of the Thinking Beyond Mechanisms segment, to talk about events in game design. Sarah talks about how to use well-designed events to provide variety, increase challenge, change up the narrative, and more when it comes to design a tabletop game.

What does it look like to engineer a business that serves your life—and not the other way around? Matthew Jarvis, founder of Jarvis Financial and co-founder of The Perfect RIA, built a thriving financial advisory firm designed for freedom. In this episode, Matthew opens up about building a “lifestyle practice,” navigating the emotional landmines of succession, and making bold moves (like taking 150+ days off a year!) without sacrificing business performance. Expect honest stories about designing a business around your values, preparing for exit from day one, and why impact, not just income, should be the endgame. If you're looking to exit right, not just exit rich, this episode will shift your thinking. [01:13 – 08:12] Design Your Life First Life by Design: Matthew shares how he built a business to support his ideal lifestyle Lifestyle Practice: Intentional client selection and lean operations Personal Metrics: Why time off mattered more than AUM growth Early Vision: Planning for exit even in the early years of growth [08:12 – 18:49] Exiting on Purpose Succession Strategy: Hand-picking his successor with the intention Founder Ego: Wrestling with identity and letting go of being “the guy” Trust and Letting Go: Setting the team up for success post-transition The Real Timeline: Why a clean break was the healthiest move [18:49 – 29:06] Impact Over Income Beyond the Check: How purpose played into exit planning The Perfect RIA: Building a second business to help others escape the grind Systems + Values: Operational freedom with a high-integrity culture Mission Alignment: The joy of helping others build lifestyle practices [29:06 – 38:55] Life After Exit Rhythms Post-Exit: How Matthew structures his time now Avoiding the Void: Creating new challenges to stay engaged Family + Freedom: Prioritizing relationships and global experiences Reinvention: The exit isn't the end—it's the beginning of significance [38:55 – 46:00] Advice for Founders Start With Why: Design your business with your life in mind Get a Coach: The power of external insight Exit Readiness: Don't wait until burnout to start the process Leave a Legacy: Measure success by your impact, not just your income Key Quotes: “If willpower were enough, we wouldn't have this discussion. I need a forcing mechanism.”— Matthew Jarvis “Successful people do things again and again. If I do those things, I'll probably get similar results.”— Matthew Jarvis Connect with Matthew! Website: https://www.theperfectria.com LinkedIn: https://www.linkedin.com/in/mpjarvis/ Ready for your next chapter? Start Your Assessment Now

SpaceTime Series 28 Episode 46The Astronomy, Space and Science News PodcastUnraveling Black Hole Jets, Martian Dust Devils, and Earth's Tectonic MysteriesIn this episode of SpaceTime, we explore groundbreaking research that sheds light on how black holes generate their powerful plasma jets. A new study reveals that these jets are formed when superheated gas experiences a rapid shrinking towards the black hole's event horizon, offering insights into galaxy evolution and the fundamental physics of black holes. We discuss the implications of these findings for understanding cosmic phenomena and the behavior of matter in extreme gravitational fields.NASA's Mars Perseverance Rover Observes Martian TwistersNext, we delve into the fascinating observations made by NASA's Mars Perseverance Rover, which has captured images of dust devils swirling on the rim of Jezero Crater. These dust devils, including one consuming another, provide important data on Martian atmospheric conditions and help refine our climate models of the Red Planet. The rover's findings highlight the role of these phenomena in influencing Martian weather and surface interactions.New Insights into Earth's Tectonic PlatesAdditionally, we discuss a new study that uncovers how anomalies in the Earth's mantle transition zone affect the movement of tectonic plates. The research suggests that thick basaltic rock compositions within this zone can influence the trajectory and speed of subducting plates, which is vital for understanding the recycling of surface materials and the long-term stability of Earth's climate. This discovery opens new avenues for studying plate tectonics and its implications for our planet's habitability.00:00 Space Time Series 28 Episode 46 for broadcast on 16 April 202500:49 Mechanisms behind black hole jet formation06:30 Implications for galaxy evolution and black hole physics12:15 Mars Perseverance Rover's dust devil observations18:00 Importance of dust devils in Martian climate studies22:45 Insights into Earth's tectonic plate movement27:00 Summary of recent geological findings30:15 Science report: Social media's impact on body imagewww.spacetimewithstuartgary.comwww.bitesz.com

Today I'm speaking with Kevin Ferber from American Cell Technology on the Longevity Optimization Podcast. In this episode, we dive into the exciting world of stem cell therapy. We discuss the process of harvesting and banking autologous stem cells, exploring the regulatory landscape surrounding stem cell therapy and its various applications in regenerative medicine and aesthetics.Kevin shares valuable insights into the mechanisms of action of mesenchymal stem cells, emphasizing the importance of proper culturing techniques for their effectiveness. Our conversation also touches on current advancements in stem cell research, potential future applications, and how these therapies can contribute to longevity and improved health outcomes.Let's be friends!Instagram: https://www.instagram.com/kaylabarnes/?hl=enTikTok: https://www.tiktok.com/@femalelongevityX: https://x.com/femalelongevityWebsite: https://kaylabarnes.comVisit American Cell Technologies with Kayla:https://www.americancelltechnology.com/kaylabarnes/Join Female Longevity Community: https://kayla-barnes-lentz.circle.so/checkout/become-a-member Follow American Cell TechnologiesInstagram: https://www.instagram.com/americancelltechnology/Facebook: https://www.facebook.com/americancelltechnologyTimestamps00:00 Introduction to Stem Cell Therapy02:08 Understanding Autologous Stem Cells05:01 Regulatory Landscape of Stem Cell Therapy07:59 Mechanisms of Action in Stem Cell Therapy10:14 Growing and Culturing Stem Cells14:45 Personal Experiences with Stem Cell Procedures18:34 Utilizing Stem Cells for Longevity21:33 Applications of Stem Cells in Aesthetics24:35 Real-World Success Stories27:25 Future of Stem Cell Therapy30:58 Cost and Accessibility of Stem Cell Banking33:26 Conclusion and Future Directions

In today's episode of Barbell Shrugged you will learn: What are lipids What is cholesterol The difference between HDL and LDL cholesterol Why there is no such thing as “good” or “bad” cholesterol What are the bloodwork numbers for optimal cholesterol What is the perfect ratio of HDL and LDL Ratios for Triglycerides to HDL for optimal health Mechanisms for regulating cholesterol in the liver Why saturated fats are not bad and how your body uses them Cholesterols role in testosterone production To learn more, please go to https://rapidhealthoptimization.com Connect with our guests: Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram Dan Garner on Instagram

In this episode of the Epigenetics Podcast, we talked with Boyan Bonev from the HelmholtzZetrum in Munich about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and primate epigenome evolution, This Episode focuses on Dr. Bonev's recent research, particularly focusing on how chromatin architecture and gene regulation influence neural cell identity and function. He discusses his work investigating transcriptional activity in relation to chromatin insulation, highlighting a critical finding that induced expression of genes does not necessarily lead to chromatin insulation—a point that complicates prior assumptions about the relationship between gene expression and chromatin organization. This study aimed to determine the causal versus correlative aspects of chromatin architecture in brain development and links it to developmental processes and neurodevelopmental disorders. Building on his findings in gene regulation, Dr. Bonev elaborates on a significant study he conducted in his own lab, where he mapped the regulatory landscape of neural differentiation in the mouse neocortex. Here, he employed cutting-edge single-cell sequencing methodologies to analyze intricate gene and enhancer interactions, revealing that selective enhancer-promoter interactions are primarily cell-type specific. This nuanced understanding aids in deciphering the complexities associated with gene expression as it relates to neural stem cells and differentiated neurons, emphasizing the importance of single-cell analyses over bulk sequencing methods. Moreover, Dr. Bonev reveals a novel methodology developed in his lab that allows for the simultaneous assessment of spatial genome organization, chromatin accessibility, and DNA methylation at high resolution. This advancement not only reduces costs but also enhances the potential to correlate higher-dimensional genomic data with specific biological questions, fostering a more integrative approach to understanding genetic regulation. The discussion then shifts focus towards Dr. Bonev's recent project profiling primate epigenome evolution, where he investigated the 3D genome organization, chromatin accessibility, and gene expression among iPSCs and neural stem cells from various species, including humans, chimpanzees, gorillas, and macaques. In this research, he identifies trends related to transcription factor evolution and chromatin modifications across species. The insights gleaned from this work underscore the evolutionary significance of structural variations in the 3D genome, pointing to a possible link between chromatin dynamics and the evolutionary development of the primate brain.   References Bonev B, Mendelson Cohen N, Szabo Q, Fritsch L, Papadopoulos GL, Lubling Y, Xu X, Lv X, Hugnot JP, Tanay A, Cavalli G. Multiscale 3D Genome Rewiring during Mouse Neural Development. Cell. 2017 Oct 19;171(3):557-572.e24. doi: https://doi.org/10.1016/j.cell.2017.09.043. PMID: 29053968; PMCID: PMC5651218. Noack, F., Vangelisti, S., Raffl, G. et al. Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler. Nat Neurosci 25, 154–167 (2022). https://doi.org/10.1038/s41593-021-01002-4 Noack F, Vangelisti S, Ditzer N, Chong F, Albert M, Bonev B. Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids. Nat Cell Biol. 2023 Dec;25(12):1873-1883. doi: 10.1038/s41556-023-01296-5. Epub 2023 Nov 23. PMID: 37996647; PMCID: PMC10709149.   Related Episodes Characterization of Epigenetic States in the Oligodendrocyte Lineage (Gonçalo Castelo-Branco) Polycomb Proteins, Gene Regulation, and Genome Organization in Drosophila (Giacomo Cavalli) The Effect of lncRNAs on Chromatin and Gene Regulation (John Rinn)   Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this episode of the Meatspad Podcast, we're joined by Dr. Wes Schilling, Professor of Meat Science, Sensory Science, and Food Chemistry at Mississippi State University. With years of industry experience and a hands-on teaching approach. We dive into the use of phosphates in meat products, what they do, their limitations, and why they're essential for improving product quality. Don't miss this episode packed with practical science and real-world applications!

Chapters 00:00 Introduction to Rotator Cuff Tendinopathy 03:13 Understanding Shoulder Pain and Its Complexities 06:04 The Shift from Impingement to Rotator Cuff Related Pain 09:00 The Role of Imaging in Shoulder Pain Diagnosis 11:58 Common Mismanagement in Shoulder Pain Treatment 15:10 Loading Programs for Rotator Cuff Rehabilitation 18:04 Positional vs. Energy Storage Tendons 20:59 The Nature of Rotator Cuff Tears 24:07 The Tipping Point to Pain in Rotator Cuff Pathology 32:53 Understanding Rotator Cuff Tears 39:26 The Role of Exercise in Recovery 46:47 Pain Management and Rehabilitation Strategies 55:19 Exploring the Mechanisms of Tendon Pain 01:00:18 The Importance of Tendon Stiffness   Takeaways Rotator cuff related shoulder pain accounts for 70-80% of shoulder pain presentations. Pain is complex and multifactorial, making diagnosis challenging. The traditional impingement model is being challenged in favor of a broader understanding of shoulder pain. Imaging often does not influence management decisions for rotator cuff issues. Corticosteroid injections provide only short-term relief and can have negative effects on tendon quality. Exercise-based management is crucial for effective rehabilitation of shoulder pain. The rotator cuff tendons are positional and strain less than energy storage tendons. Rotator cuff tears are common and can exist without pain or dysfunction. Age is the biggest risk factor for developing rotator cuff pathology. Understanding the tipping point to pain is essential for effective treatment. Rotator cuff tears are often associated with poor vascular supply and degeneration over time. Metabolic factors like diabetes and smoking can increase the risk of rotator cuff tears. Exercise can be as effective as surgery for massive rotator cuff tears. Expectations of recovery significantly influence rehabilitation outcomes. Education about the commonality of tendon tears can help reduce patient anxiety. Pain during exercise can be tolerated up to a certain level without adverse effects. Sleeping positions can impact shoulder pain and should be modified accordingly. Adjunct treatments like shockwave therapy and corticosteroids have limited long-term benefits. Tendon stiffness is important for efficient force transfer, but its role in pain management is still being studied. Understanding the psychological aspects of pain can enhance recovery from tendon injuries. Website: https://www.shoulderphysio.com Twitter: https://x.com/JaredPowell12 Instagram: https://www.instagram.com/shoulder_physio/?hl=en Notes: https://jackedathlete.com/podcast-140-rotator-cuff-tendons-with-jared-powell/

SpaceTime Series 28 Episode 41The Astronomy, Space and Science News PodcastMysterious Red Sprite Lightning, Shocking Spherules on Mars, and a New Geological Map of the Asteroid BeltIn this episode of SpaceTime, we explore the breathtaking phenomenon of red sprite lightning captured over the Himalayas. Chinese astrophotographers documented over 100 of these rare electrical discharges, revealing insights into the complex thunderstorms of the region. We discuss the mechanisms behind these sprites and their implications for understanding upper atmospheric phenomena.Shocking Discoveries on MarsNext, we turn our attention to Mars, where NASA's Perseverance rover has uncovered a strange rock formation composed of hundreds of millimeter-sized spheres. This unexpected discovery raises questions about the geological processes that could create such features, prompting scientists to investigate their origins and significance for Mars' geological history.New Geological Map of the Asteroid BeltAdditionally, we delve into a new geological map of the main asteroid belt between Mars and Jupiter, which has been developed to enhance our understanding of meteorite origins and planetary defense. This groundbreaking work traces the impact orbits of meteorites, providing a clearer picture of how asteroid collisions contribute to the debris we observe on Earth.00:00 Space Time Series 28 Episode 41 for broadcast on 4 April 202500:49 Capturing red sprite lightning over the Himalayas06:30 Mechanisms behind the upper atmospheric electrical discharges12:15 Discovery of strange spherules on Mars18:00 Implications for Martian geology and history22:45 New geological map of the asteroid belt27:00 Summary of recent astronomical findings30:15 Skywatch: Highlights of April night skieswww.spacetimewithstuartgary.comwww.bitesz.com

In this conversation, Chris Burres, founder and chief scientist officer at My Vital C, discusses his journey from comedy improv to the world of health supplements, particularly focusing on the Nobel Prize-winning molecule ESS-60. He shares insights on its remarkable effects on longevity, the transition into the supplement industry, and the importance of quality and research in health products. The discussion also touches on testimonials, the mechanisms of action behind ESS-60, and future projects aimed at furthering research in longevity and health.Chapters00:00 Introduction to Chris Burres and His Journey02:57 The Power of Comedy Improv in Communication06:00 The Discovery of ESS-60 and Its Nobel Prize Connection08:49 The Longevity Experiment: 90% Life Extension in Rats11:49 Transitioning to the Supplement Industry14:56 Understanding the Mechanisms of ESS-6018:00 The BOSS Theory: Buffering Oxidative Stress System20:46 Real-World Applications and Testimonials24:10 Human Studies and Future Research Directions28:43 The Importance of HSCRP Levels29:41 Insights from Sleep Studies32:08 Translating Rat Studies to Human Applications34:27 Understanding Product Authenticity in the Market36:23 The Science Behind ESS-6040:40 Manufacturing Process and Quality Control43:38 The Motivation Behind the Product45:00 Daily Usage and Personal Experiences51:32 Future Projects and Exciting Developments54:05 Connecting with My Vital C

In Episode 242 Steph Hodge joins us to discuss our top 5 quirky mechanisms in board games.You can find Steph's blog here: https://boardgamegeek.com/blog/3802/all-the-meeples-of-the-rainbow and her videos here: https://www.youtube.com/@boardgamerstephTimestamps:00:00 Introduction05:12 Top 5 Quirky Mechanisms08:11 Marrakesh11:24 Time of Empires14:00 Euphoria: Build a Better Dystopia17:34 Truffle Snuffle19:25 Keyper22:00 Viscounts of the West Kingdom24:50 Trotofant27:45 Redwood30:31 Black Orchestra34:10 Argo37:13 Once Upon a Line39:23 Greedy Kingdoms42:58 The Faceless45:35 Piazza Rabazza48:24 Dungeon Petz52:49 Honorable Mentions: Picture Perfect, Dungeon Fighter, Canvas, Captain Sonar, Turing Machine, Treasure Island, Bullet Heart, Mord Im ArosaIf you enjoy the show, please consider supporting us at https://www.patreon.com/boardgamehottakesFollow us on BlueSky: https://bsky.app/profile/boardgamehottakes.bsky.socialJoin our Board Game Arena Community: https://boardgamearena.com/group?id=11417205Join our Discord server at: ⁠⁠⁠⁠⁠⁠⁠https://discord.gg/vMtAYQWURd

Today I'm speaking with Dr. Stephanie Venn-Watson on the Longevity Optimization Podcast. In this episode, we discuss the intriguing concept of longevity molecules, with a particular focus on C15 fatty acid and its implications for health and aging. Our conversation explores various longevity molecules, their mechanisms, and the surprising findings from research on dolphins that led to the discovery of C15 as a key factor in healthy aging. We emphasize the importance of understanding dietary sources of C15 and its role in promoting longevity and overall health. Dr. Stephanie Venn-Watson is a leading researcher in the field of longevity and nutrition, dedicated to uncovering the connections between dietary components and health outcomes. Throughout our discussion, we delve into the significance of C15 fatty acid in relation to aging, health, and nutrition. We highlight how C15 influences biological age, cell stability, and the implications of iron overload. The conversation also explores the multifaceted benefits of C15, particularly for women's health and infant nutrition, while emphasizing the importance of optimizing C15 levels for overall well-being. Additionally, we draw parallels between the longevity of dolphins and human health, introducing emerging research on C15's role in mental health, providing listeners with valuable insights into this promising area of study.Save on Fatty15: https://fatty15.com/KAYLACode: KAYLALet's be friends!Instagram: https://www.instagram.com/kaylabarnes/?hl=enTikTok: https://www.tiktok.com/@femalelongevityX: https://x.com/femalelongevityWebsite: https://kaylabarnes.comJoin Female Longevity Community: https://kayla-barnes-lentz.circle.so/checkout/become-a-memberFollow Fatty15 and Dr. Stephanie Venn-WatsonFatty15Website: https://fatty15.com/Instagram: https://www.instagram.com/fatty15/Dr. Stephanie Venn-WatsonLinkedin: https://www.linkedin.com/in/stephanievennwatsonTimestamps00:00 Introduction to Longevity and Health02:48 Understanding Longevity Molecules05:54 Mechanisms of Longevity Molecules08:55 Research on Dolphins and Aging12:06 The Discovery of C15 Fatty Acid14:53 C15 vs Omega-3 Fatty Acids18:02 C15's Role in Longevity20:53 C15 Levels and Health Outcomes23:58 C15 in Diet and Lifestyle28:30 The Role of C15 in Aging and Cell Stability31:24 Understanding Iron Overload and Its Health Implications34:38 C15: A Multifaceted Molecule for Health37:15 C15 and Its Impact on Women's Health40:04 The Importance of C15 in Infant Nutrition42:01 Optimizing C15 Levels for Better Health44:42 Lessons from Dolphins: Longevity and Health52:27 Emerging Research on C15 and Mental Health

Dietitian's, Aidan Muir & Leah Higl, dive into the effectiveness of fat burners. They explore the mechanisms by which fat burners are believed to work, including increased metabolic rate, appetite suppression, and fat oxidation. The discussion also covers common ingredients found in them, and what the current body of research shows. (0:00) - Introduction (1:11) - Mechanisms for How They Could Work (2:04) - Analysis of Those Mechanisms (5:22) - Individual Ingredients (9:01) - Research Findings (10:17) - Our Interpretation & Recommendations   WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en   Our dietitians

Mike Matthews investigates the fascinating news from the beginning of the week and Mike answers what the pet industry has ramped up to. Join Mike as he podcasts live from Café Anyway in podCastro Valley with Benita, the Disgruntled Fiddle Player, and the Brewmaster. Next show it's Madame Rootabega, Valentino, and Bison Bentley.

- Music Video Introduction and Interview Announcement (0:00) - Gut Health Program and Interview with Mellow Cat (4:11) - Radical Left Attacks and Judicial Interference (6:06) - Trump's Aggressive Stance and Radical Left's Violence (9:15) - White College Educated Women and Trump Derangement Syndrome (11:49) - Special Report on Vaccines and Bio-Weapons (22:24) - Book Review: 20 Mechanisms of Injuries by Dr. Sherry Tenpenny (27:37) - Chemtrails, HAARP, and Full Spectrum Dominance (34:42) - Mayor of Boston's Defiance and Trump's Response (1:04:21) - Interview with Maxime Bernier: Canada's Populist Movement (1:06:18) - Maxime Bernier's Political Journey and Platform (1:23:50) - Canadian Media Bias and Political Campaigning (1:26:55) - Prime Minister Justin Trudeau and Canadian Politics (1:30:39) - Economic and Energy Policies in Canada (1:35:29) - Immigration and Cultural Integration in Canada (1:49:57) - Trade Relations with the US and Global Politics (1:58:50) - Financial Challenges and Future Prospects (1:59:22) - Cultural Preservation and National Identity (2:06:05) - Conclusion and Final Thoughts (2:07:52) For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we're helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency. ▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com

We are living through perilous times—an age of anxiety, crisis, and polarization. In this return to the Our Cultural Crisis series, we explore the 9 mechanisms—emotivism, blindness, tribalism, victimization, moral posturing, de-humanization, outrage, one-sidedness, and violence—that drive our current predicament. These dynamics are as old as time but pertinent as ever. By naming them, we can engage the work of transcending them, sobering up to our times and reckoning how to live powerfully and humbly in such an age of anxiety.

John Dich shares his profound journey of healing and self-forgiveness after experiencing incarceration. He discusses his upbringing in an immigrant family, the search for validation that led him to a gang lifestyle, and the challenges he faced in prison. John reflects on his transformation, the importance of impulse awareness, and the steps he took towards self-care and emotional healing. He emphasizes the significance of forgiving oneself and understanding the inner child, ultimately highlighting the ongoing struggle of recovery and personal growth.Chapters (00:00) Journey of Healing and Self-Forgiveness(05:26) Life in Prison: Coping Mechanisms and Daily Routine(10:33) Transformation and Release: The Path to Freedom(15:32) Navigating Life After Incarceration(20:33) Impulse Awareness and Self-Care Strategies(25:18) The Importance of Self-Forgiveness and Healing the Inner ChildJohn Dich IG:https://www.instagram.com/igotdarunz/Follow Me on Social Media:https://www.instagram.com/thevoncastshow/https://www.instagram.com/shibavon/ https://www.iamvon.net/

What if a single molecule could rewrite your health story, slashing inflammation, supercharging your energy, and maybe even adding years to your life? I just went deep into the science in this episode with Alex Tarnova, the genius behind H2Tab. We unpack how hydrogen water benefits your body in ways you never imagined. This isn't just another biohacking fad—it's a game-changer backed by cutting-edge research, and it's so simple you'll wonder why you haven't tried it yet! What's stopping you from unlocking your potential—could it be as simple as a glass of water? Join the Ultimate Human VIP community and gain exclusive access to Gary Brecka's proven wellness protocols today!: https://bit.ly/4ai0Xwg Connect with Alex Tarnava: Website: https://bit.ly/4bHBqxo  Instagram: https://bit.ly/4iECIeN  LinkedIn:https://bit.ly/4hiaLbL  Thank you to our partners: H2TABS - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/41o6HSC BODYHEALTH - USE CODE “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV BAJA GOLD - USE CODE "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa EIGHT SLEEP - SAVE $350 ON THE POD 4 ULTRA WITH CODE “GARY”: https://bit.ly/3WkLd6E STRENGTH TRAINING EQUIPMENT - THE ULTIMATE HUMAN: https://bit.ly/3zYwtSl COLD LIFE - THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp WHOOP - GET 1 FREE MONTH WHEN YOU JOIN!: https://bit.ly/3VQ0nzW MASA CHIPS - GET 20% OFF YOUR FIRST $50+ ORDER: https://bit.ly/40LVY4y VANDY - USE CODE “ULTIMATE20” FOR 20% OFF: https://bit.ly/49Qr7WE PARKER PASTURES - PREMIUM GRASS-FED MEATS: https://bit.ly/4hHcbhc AION - USE CODE “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD HAPBEE - FEEL BETTER & PERFORM AT YOUR BEST: https://bit.ly/4a6glfo CARAWAY - USE CODE “ULTIMATE” FOR 10% OFF: https://bit.ly/3Q1VmkC HEALF - GET 10% OFF YOUR ORDER: https://bit.ly/41HJg6S BIOPTIMIZERS - USE CODE “ULTIMATE” FOR 10% OFF: https://bit.ly/4inFfd7 Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka: Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X.com: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps: 00:00 ​Intro of Show 00:03:00 - Alex's Personal Journey Begins 00:06:05 - Inflammation Marker Explained 0:08:08 - Early Hydrogen Experiments 00:11:38 - Developing H2Tab 00:12:28 - Magnesium Bioavailability Bonus 00:14:16 - Partnering with Dr. Richard Holland 00:18:49 - Hydrogen vs. Caffeine Studies 00:19:56 - Anti-Aging Research (Journal of Experimental Gerontology) 00:25:33 - Mechanisms of Hydrogen in the Body 00:31:31 - Hydrogen for Sports Performance 00:34:42 - Anti-Inflammatory Mechanism 00:37:08 - Hydrogen Baths Anecdote 00:48:12 - Gut Health Benefits 0:50:56 - How to Use H2Tab 00:54:12 - Pre-Exercise Hydrogen “Bomb” 00:55:45 - Olympic Athlete Study 00:57:38 - Gender-Specific Benefits 00:59:50 ​“What does it mean to you to be an Ultimate Human?” The Ultimate Human with Gary Brecka Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The Content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this special guest episode, Sen and Erica welcome Sarah Shipp to talk about how designers can raise the stakes to strengthen a game's hook, taking it from bland to bold!

In tonight's episode of Iron Culture, Eric Trexler and Eric Helms discuss various topics related to fitness, training, and research. They share personal updates, including the toll that Helms' intense training regimen is taking on his face. The discussion then shifts to the upcoming NFL combine, highlighting the impressive athletic feats expected from past combine participants. In the main segment of the show, Trexler and Helms discuss the nuances of lengthened-biased training research – more specifically, why we shouldn't give up on the strategy just because a few studies reporting non-significant results have come along. In this conversation, Trexler and Helms explore the concept of sampling error in research, emphasizing the importance of understanding some foundational statistical concepts and the need for several studies to draw reliable conclusions. They explore the challenges of uncertainty in evidence-based practice, the balance to strike between mechanistic and empirical approaches to understanding exercise and nutrition, and the resistance to change in learning. Finally, they engage in a rapid-fire Q&A session addressing a handful of fitness-related questions. The MASS crew records Iron Culture LIVE on YouTube, Monday nights at 7pm eastern time. Be sure to join us for a future episode and say hello in the live chat!  If you'd like to submit a question or topic for us to address on an upcoming episode, please use this link:  https://massresearchreview.com/ironculture Time Stamps: 00:00 Introduction and why Trexler is worried about Helms 6:40 Q&A NFL Combine analysis Trexler 2017 Fat-Free Mass Index in NCAA Division I and II Collegiate American Football Players https://pubmed.ncbi.nlm.nih.gov/27930454/  13:18 Getting into the science with Helms' upcoming MASS article on long muscle length training Burke 2006 "Fat adaptation" for athletic performance: the nail in the coffin? https://pubmed.ncbi.nlm.nih.gov/16357078/ Nunes 2022 Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults https://pubmed.ncbi.nlm.nih.gov/35187864/ Larsen 2024 The effects of hip flexion angle on quadriceps femoris muscle hypertrophy in the leg extension exercise https://pubmed.ncbi.nlm.nih.gov/39699974/ Gschneider 2024 The effects of lengthened-partial range of motion resistance training of the limbs on arm and thigh muscle cross-sectional area https://sportrxiv.org/index.php/server/preprint/view/485/version/624 Wolf 2025 Lengthened partial repetitions elicit similar muscular adaptations as full range of motion repetitions during resistance training in trained individuals https://pubmed.ncbi.nlm.nih.gov/39959841/ Kassiano 2022 Does Varying Resistance Exercises Promote Superior Muscle Hypertrophy and Strength Gains? A Systematic Review https://pubmed.ncbi.nlm.nih.gov/35438660/ Pedrosa 2023 Training in the Initial Range of Motion Promotes Greater Muscle Adaptations Than at Final in the Arm Curl https://pubmed.ncbi.nlm.nih.gov/36828324/ 29:59 Simulating a large lengthened-bias training dataset 42:28 Some points from Trexler Trexler 2019 Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/30895562/ 1:02:56 Mechanisms vs experimental trials (uncertainty) 1:10:15 Using Large Language Models for statistical analysis (in R) 1:21:01 Q&A Rapid fire 1: Work and energy expenditure during eccentric contractions   1:23:22 Q&A Rapid fire 2: Waited vest upsides and downsides 1:25:47 Q&A Rapid fire 3: Protein recommendations for individuals who don't train their entire body 1:29:20 Q&A Rapid fire 4: Sprint cycling for quad hypertrophy   1:35:04 Wrapping up See the entire MASS team speak at the Sports Nutrition Association Annual Conference https://sportsnutritionassociation.com/sna-annual-2025-conference/