Podcasts about mechanisms

Send us a textPharmacology & neurobiology of psychedelics & MDMA, focusing on isomers, sex-specific effects, and mechanisms in animal models. Not medical advice.TOPICS DISCUSSED:Biased agonism: Different drugs activate the same receptor (e.g., 5-HT2A) but trigger varied intracellular pathways, explaining why LSD is psychedelic while similar lisuride is not.Enantiomers & isomers: Mirror-image versions of drugs like MDMA (S and R forms) and LSD (four isomers) often produce distinct effects; only one LSD isomer is psychedelic, for example.MDMA isomer effects: S-MDMA induces stronger head twitches (psychedelic proxy) via serotonin release, and increases dendritic spines in male mice but not females; R-MDMA has somewhat different effects.Sex-specific drug responses: In mice, females show stronger psychedelic effects (head twitches) from psilocybin and DOI at the same dose, but males exhibit greater post-acute benefits like reduced opioid withdrawal.Psilocybin in opioid addiction models: A single dose reduces place preference for oxycodone and withdrawal symptoms in male mice more than females, with opposite spine density effects in reward-related brain areas.Mechanisms beyond 5-HT2A: Psychedelics involve other receptors like metabotropic glutamate receptors, forming dimers with 5-HT2A to enable dual signaling pathways; effects in subcortical regions like nucleus accumbens are 5-HT2A-independent.Clinical implications: Street MDMA may vary in S/R ratios, affecting experiences; clinical trials often use racemic mixtures without weight-adjusted dosing, potentially missing sex differences.ABOUT THE GUEST: Javier Gonzalez-Maeso, PhD is a professor of pharmacology and toxicology at Virginia Commonwealth University, with a PhD in medicine from Spain focused on G-protein coupled receptors and human brain studies in depression and addiction.RELATED EPISODE:M&M 230 | Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael WheelerSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

In this episode we answer questions from Ben, Todd, and Tom. We discuss how managed futures differ from momentum, differentiating Monte Carlo simulations and why you need to be careful with parameterized simulations, and flexible withdrawal strategies generally and applied to the sample portfolios.LInks:QMOM and DBMF comparison and correlations:  testfol.io/analysis?s=5lCK1KCsAsxMorningstar 2025 State of Retirement Income Report:  Morningstar State_of_Retirement_Income_2025.pdf - Google DrivePortfolio Charts Annual Returns Calculator:  Annual Returns – Portfolio ChartsBreathless Unedited AI-Bot Summary:Ever wondered why a momentum stock fund and a managed futures fund can look similar on the surface yet behave like opposites when markets lurch? We dig into the real differences between equity momentum strategies like QMOM and multi-asset trend programs like DBMF, explaining how managed futures trade across stocks, bonds, commodities, and currencies with the ability to go long and short. That breadth—and the discipline to follow trends over weeks to a year—creates low correlation to traditional portfolios and turns macro chaos into potential opportunity.From there, we tackle the Monte Carlo confusion that trips up even seasoned planners. We compare historical shuffles that preserve real-world co-movements with parameterized simulations that assume normal distributions and independence—two assumptions markets love to break. You'll hear why fat tails matter, how “impossible” scenarios sneak into naïve models, and where to find usable inputs without double-counting inflation. We also share a simple framework: use multiple calculators, add historical stress tests starting in rough windows like 1968 or 2000, and look for consistent results across tools before you trust any forecast.Finally, we turn to retirement withdrawals and the habits that actually hold up. Instead of rigid CPI bumps, we walk through constant-percentage withdrawals, guardrails, and the reality that retiree spending tends to run at CPI minus 1–2 percent outside healthcare. We highlight how flexible rules can raise sustainable withdrawal rates and why resilient portfolio design—think Golden Butterfly or Golden Ratio—can outperform a classic 60/40 under severe sequences. If you're ready to upgrade your plan with better diversification, better testing, and smarter spending rules, you'll leave with practical steps you can apply today.Enjoyed the conversation? Subscribe, leave a review, and share this episode with a friend who's serious about building a portfolio that survives bad markets. What testing change will you make this week?Support the show

Most people think dementia starts with memory loss. But for millions, it actually begins decades earlier: in the blood vessels. Long before someone forgets a name or misses an appointment, the brain is being quietly damaged by high blood pressure, cholesterol imbalance, poor sleep, inflammation, and chronic stress, day after day, year after year. This kind of damage doesn't look dramatic. There's no big stroke, no clear warning sign. It happens slowly and silently, which is why it's so often missed until it's too late. But here's the good news: vascular dementia is one of the most preventable and manageable forms of cognitive decline. When caught early, lifestyle changes and medical interventions can help slow the onset and manage the effects. In this episode, we explore: What vascular dementia and vascular cognitive impairment are, and how they differ from Alzheimer's disease Why most dementia cases involve both vascular damage and neurodegenerative pathology (mixed dementia) How blood vessel damage begins in childhood and accumulates silently for decades The role of high blood pressure, cholesterol, diabetes, sleep disorders, and chronic stress in damaging brain vasculature Why slowed thinking, movement, and processing speed are hallmark signs of vascular cognitive decline The critical importance of the endothelium: the thin lining of blood vessels that controls brain health How lifestyle factors like nutrition, exercise, sleep, and stress management protect and repair vascular health Why managing blood pressure early is one of the most powerful interventions for long-term brain health (and why everyone should have a blood pressure monitor at home!) How vascular damage can be slowed, even in midlife Practical steps for prevention across the lifespan, from childhood through older adulthood Our guest for this episode is DR. COLUMBUS BATISTE, a board-certified interventional cardiologist, an incredible science communicator, and author of 'Selfish: A Cardiologist's Guide to Healing a Broken Heart'. Dr. Batiste brings deep expertise on how cardiovascular health shapes brain health, and why protecting the endothelium (the inner lining of blood vessels) is foundational to longevity. His work emphasizes that all roads to longevity are paved by the heart, and what's good for the heart is good for the brain! 'Your Brain On…' is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai. SUPPORTED BY: NEURO World, a science-based brain health community designed to help you protect your brain long before problems begin. Learn more at https://neuro.world/  'Your Brain On… Vascular Dementia' • SEASON 6 • EPISODE 8 ——— LINKS Dr. Columbus Batiste: https://drbatiste.com/  Instagram: @HeartHealthyDoc Facebook: https://www.facebook.com/drbatiste  ——— FOLLOW US Join NEURO World: https://neuro.world/   Instagram: https://www.instagram.com/thebraindocs   YouTube: https://www.youtube.com/thebraindocs ——— REFERENCES Core Definitions & Diagnostic Framework • Diagnostic and Statistical Manual of Mental Disorders (5th ed.) - American Psychiatric Publishing • Vascular contributions to cognitive impairment and dementia - https://doi.org/10.1161/STR.0b013e3182299496 • Classifying neurocognitive disorders: The DSM-5 approach - https://doi.org/10.1038/nrneurol.2014.181  Epidemiology & Public Health Burden • Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease - https://doi.org/10.1007/s00401-016-1571-z • Vascular dementia - https://doi.org/10.1016/S0140-6736(15)00463-8  • Risk reduction of cognitive decline and dementia: WHO guidelines - WHO Press Small Vessel Disease & Subcortical Vascular Dementia • Small vessel disease: Mechanisms and clinical implications - https://doi.org/10.1016/S1474-4422(19)30079-1  • Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges - https://doi.org/10.1016/S1474-4422(10)70104-6  • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging - https://doi.org/10.1136/bmj.c3666  Mixed Dementia & Alzheimer–Vascular Overlap • Mixed brain pathologies account for most dementia cases in community-dwelling older persons - https://doi.org/10.1212/01.wnl.0000271090.28148.24 • Early role of vascular dysregulation on late-onset Alzheimer's disease - https://doi.org/10.1016/j.neurobiolaging.2016.04.009 • The pathobiology of vascular dementia - https://doi.org/10.1016/j.neuron.2013.10.008  Cerebral Amyloid Angiopathy (CAA) • Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways - https://doi.org/10.1038/s41582-019-0281-2 • Emerging concepts in sporadic cerebral amyloid angiopathy - https://doi.org/10.1093/brain/awx047 Genetics, Inflammation, and Repair • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A - https://doi.org/10.1038/nature11087 • TREM2—A key player in microglial biology and Alzheimer disease - https://doi.org/10.1038/s41582-018-0072-1  Prevention & Vascular Risk Factors • Dementia prevention, intervention, and care: 2020 report of the Lancet Commission - https://doi.org/10.1016/S0140-6736(20)30367-6  • Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease - https://doi.org/10.1038/s41582-018-0070-3  Further Reading • The role of vascular risk factors in Alzheimer's disease - https://doi.org/10.1038/s41582-021-00530-4

While the term "hyperpalatable" has been used frequently for considerable time to refer to foods that are so appealing and tasty that they drive overeating, this term hasn't been well-defined nor has there been a universal standard for what it means. One researcher who set out to create an objective definition for hyper-palatable foods (HPFs) is Dr. Tera Fazzino. Using specific defined thresholds of sugar, fat and salt combinations, Dr. Fazzino and colleagues have looked at the impact of consumption of these HPFs. In this episode, we delve into defining HPFs and their nutrient profiles, whether they have addictive-like properties, how HPFs differ from (and overlap with) ultra-processed foods (UPFs), the mechanisms by which these foods drive overconsumption, and the broader public health implications. Tera Fazzino, PhD, is an associate professor of psychology at the University of Kansas. Her research focuses on addiction, obesity, and eating-related behaviors. Timestamps [03:39] Interview begins [05:05] Attempting to define hyper palatability [10:03] Nutrient combinations in hyper palatable foods [14:54] Prevalence of hyper palatable foods [17:43] Debate on ultra processed foods [30:02] Mechanisms behind hyper palatability [35:06] Addiction theory and hyper-palatable foods [43:38] Early exposure and long-term effects [50:53] Key ideas recap Related Resources Go to episode page (with links to studies mentioned) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course

What mechanisms actually drive sustainable growth? What if your business processes were predictable and repeatable?In this episode of The Business Ownership Podcast I interviewed Nick Foy. Nick - Founder, CEO, Chief Evangelist - Over 30 years of experience working in business and technology consulting and leadership have led Nick to focus on "democratizing ERP" for effective and consistent growth. His company provides access to world-class processes, systems, and change management methods regardless of their size or budget. With over 30-years of experience in business and technology consulting and leadership positions at Amazon, and Capgemini Consulting. Scaling isn't about working harder — it's about better systems. Learn how to build mechanisms for business.Check this out!Show Links:Nick Foy on LinkedIn: https://www.linkedin.com/in/nickfoy/Silverdale Website: https://www.silverdaletech.com/Book a call with Michelle: https://go.appointmentcore.com/book/IcFD4cGJoin our Facebook group for business owners to get help or help other business owners!The Business Ownership Group - Secrets to Scaling: https://www.facebook.com/groups/businessownershipsecretstoscalingLooking to scale your business? Get free gifts here to help you on your way: https://www.awarenessstrategies.com/

Guest: Dr. Joseph Wu is a Professor of Medicine and Radiology and the Director of the Stanford Cardiovascular Institute. He talks about the importance of pharmacology knowledge in drug discovery. He also discusses his early iPSC research, investigating vaccine-induced myocarditis, and embracing New Approach Methodologies (NAMs). (39:40) Featured Products and Resources: Submit your abstract for ISSCR 2026 by February 25th! STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit The Stem Cell Science Round Up Autism Genes in Organoids: Research provides new insight into the convergent impact of autism spectrum disorder genetic risk on human neurodevelopment. (2:35) Pancreatic Organoid Screening: High-content screen reveals 54 compounds altering pancreatic organoid shape or differentiation. (13:15) CRISPR Screening for Tauopathies: CRISPR screens in human neurons reveal modifiers of tau oligomer accumulation. (21:03) Fixing Facial Scarring: Modulating ROBO2-EID1-EP300 signaling pathway promotes facial-like reduced fibrosis at scar-prone sites. (31:00) Image courtesy of Dr. Joseph Wu Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Derrick Van Every is a PhD candidate at Stu Phillips' Protein Metabolism Lab as well as a powerlifting and nutrition coach.In this episode, we discuss the topics he addressed in one of his recent published papers, namely:What are the main drivers of hypertrophy?Does the pump cause hypertrophy?What about training-related hormonal increases?… And more!Links and resources:Derrick's paper – “Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions”: ⁠https://www.sciencedirect.com/science/article/pii/S2095254625000869⁠Connect with Derrick on Instagram @derrick_cbb: ⁠https://www.instagram.com/derrick_cbb/⁠ Sign up for one on one coaching with me: ⁠⁠https://www.fittotransformtraining.com/coaching.html⁠⁠Follow me on Instagram @nikias_fittotransform: ⁠⁠http://instagram.com/nikias_fittotransform/⁠⁠Visit my website: ⁠⁠https://www.fittotransformtraining.com⁠⁠Sign up for my free newsletter: ⁠⁠https://mailchi.mp/157389602fb0/mailinglist⁠⁠Subscribe to my YouTube channel: ⁠https://www.youtube.com/@nikias_fittotransform⁠ Sign up for the No Quit Kit email series on retraining your mindset for long-term fat loss success: ⁠⁠https://mailchi.mp/4b368c26baa8/noquitkitsignup⁠⁠Take my free “Should You Cut or Bulk First?” quiz: ⁠https://nikias-dddr9p81.scoreapp.com/⁠ 

Kevin Frazier warns of regulatory capture in AI governance, cautioning that dominant tech companies may co-opt oversight mechanisms, stifling competition and shaping rules to entrench their market dominance.1931

When allergy meds aren't enough, how do you choose the form of immunotherapy that will work best for your patient? Board-certified allergist-immunologist Dr. Nikhila Schroeder and host Dr. Basil Kahwash answer that question and more in this episode of the BackTable ENT Podcast. --- SYNPOSIS Dr. Schroeder shares her path from an engineering background to becoming a board-certified pediatric and adult allergist-immunologist, offering insight into how that perspective shapes her approach to patient care. The discussion focuses on the nuances of sublingual immunotherapy (SLIT) versus subcutaneous immunotherapy (SCIT), including administration, efficacy, safety, and patient adherence challenges. They also explore how immunotherapy can modulate the immune system and provide long-term symptom relief. Dr. Schroeder concludes by sharing her vision for the future of allergy immunotherapy, highlighting the accessibility and growing potential of SLIT. This episode offers ENT specialists a practical overview of why understanding and integrating allergy-immunotherapy can benefit both their practice and their patients. --- TIMESTAMPS 00:00 - Introduction05:01 - History and Evolution of Immunotherapy10:36 - Mechanisms of Immunotherapy14:59 - Subcutaneous Immunotherapy: Process and Benefits19:52 - Sublingual Immunotherapy: Process and Benefits27:56 - Comparing Subcutaneous and Sublingual Immunotherapy34:14 - Efficacy Comparison: Allergy Shots vs. SLIT39:51 - Patient Adherence and Treatment Choices41:58 - Contraindications for Allergy Immunotherapy48:58 - Long-term Benefits of Immunotherapy59:26 - Key Takeaways for ENT Professionals --- RESOURCES Dr. Nikhila Schroeder https://allergenuityhealth.com/about-us/

In this episode of the Flex Diet Podcast, I sit down with Dr. Cas Fuchs from Maastricht University to dive into the science behind cold water immersion. We discuss its impact on muscle recovery, protein synthesis, and overall performance. Dr. Fuchs shares his latest research findings, debunking common myths and providing actionable insights for athletes and fitness enthusiasts.Plus, we touch on the effects of different carbohydrates on glycogen resynthesis and liver function. Whether you're a gym-goer or a seasoned athlete, this episode is packed with valuable information to optimize your training and recovery strategies.Sponsors:Fitness Insider Newsletter: https://miketnelson.com/Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:02:15 Starting the Discussion with Dr. Fuchs03:05 Research on Cold Water Immersion04:39 Mechanisms and Effects of Cooling on Muscle Recovery12:08 Long-Term Effects of Cold Water Immersion24:01 Comparing Cooling and Heating Protocols32:35 Placebo Effects and Practical Applications37:57 Debunking Cold Water Immersion for Fat Loss41:01 Exploring the Effects of Cold Water Immersion on Endurance41:50 The Role of Temperature in Muscle Physiology42:40 Practical Applications of Cold Water Immersion44:43 The Myth of Cooling Devices for Performance Enhancement48:37 Pre-Exercise Cold Water Immersion: Benefits and Drawbacks50:58 Glycogen Resynthesis and Carbohydrate Types01:02:50 Recent Research on Breakfast and Liver Glycogen01:06:13 Upcoming Studies and Bodybuilder Research01:09:10 Cold Water Immersion Tips for Gym Goers01:10:40 Conclusion and Contact Information Flex Diet Podcast Episodes You May Enjoy:Episode 202: Cold water immersion and the body's regulation systems: An interview with Dr. Dwayne JacksonYouTube: https://youtu.be/3UfPcOJdmIA?si=Vu4FT12Z5gd4JXkxEpisode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil BattersonYouTube: https://youtu.be/PPZyO1nxSPA?si=7BjCBIQBbs7srclyConnect with Cas:Instagram: https://www.instagram.com/casfuchsLinkedIn: https://www.linkedin.com/in/casfuchsGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

Circana's Sally Lyons Wyatt walks us through new research from the global consulting firm's that reveals just how dramatically GLP-1 medications are shifting U.S. consumer eating and purchasing behavior—and how CPG brands and retailers can get ahead of increasing consumer demand. Nutrition and metabolism researcher Kevin Hall unpacks the latest science on ultra-processed foods, explaining why debates over definitions often miss the deeper mechanisms driving excess calorie intake, and explores how food scientists, nutrition researchers, and industry innovators can work together to develop healthier, evidence-based products for the future. Plus: This episode of Omnivore is brought to you by IFT Membership. It's where you belong. As a member, you'll enjoy a global community united by purpose and driven by science ready to make a lasting impact on the global food system. Visit ift.org/join.

Derrick Van Every is a PhD candidate at Stu Phillips' Protein Metabolism Lab as well as a powerlifting and nutrition coach.In this episode, we discuss the topics he addressed in one of his recent published papers, namely:What are the main drivers of hypertrophy?Does the pump cause hypertrophy?What about training-related hormonal increases?… And more!Links and resources:Derrick's paper – “Load-induced human skeletal muscle hypertrophy: Mechanisms, myths, and misconceptions”: https://www.sciencedirect.com/science/article/pii/S2095254625000869Connect with Derrick on Instagram @derrick_cbb: https://www.instagram.com/derrick_cbb/ Sign up for one on one coaching with me: ⁠https://www.fittotransformtraining.com/coaching.html⁠Follow me on Instagram @nikias_fittotransform: ⁠http://instagram.com/nikias_fittotransform/⁠Visit my website: ⁠https://www.fittotransformtraining.com⁠Sign up for my free newsletter: ⁠https://mailchi.mp/157389602fb0/mailinglist⁠Subscribe to my YouTube channel: https://www.youtube.com/@nikias_fittotransform Sign up for the No Quit Kit email series on retraining your mindset for long-term fat loss success: ⁠https://mailchi.mp/4b368c26baa8/noquitkitsignup⁠Take my free “Should You Cut or Bulk First?” quiz: https://nikias-dddr9p81.scoreapp.com/ 

Special Episode 82 (Trivia): Board Game Mechanisms How well do you really know game mechanics? In this trivia-style episode, we dive into worker placement, design complexity, and the language gamers use—inviting listeners to play along as we break down what makes these systems tick.  Thanks for listening! Enjoy Timestamps:  00:00 Introduction 00:38 Chris's 15 Trivia Questions (Mechanisms) Play along with us! Have any great trivia questions for us? Email us at thefifthmeeple@gmail.com and maybe we'll put your trivia up on our podcast in the future (10 questions minimum| 15 questions max) as always play more board games!

https://youtu.be/dmwUiZqwgG8

Join Clean Counts' leadership as they discuss the real-world impact of renewable energy certificates (RECs) on today's energy markets. This episode explores how robust verification, evolving market demands, and new attributes like pollinator-friendly certifications are shaping the sector. The conversation details how Clean Counts' systems operate, the economic and policy context, and the practical implications for renewable energy producers and buyers nationwide.   Topics Covered Clean Counts www.cleancounts.org REC = Renewable Energy Certificate SREC = Solar Renewable Energy Certificate (Solar Energy Certificates Market) Clean Energy Verification Utility Pollinator Friendly SREC Agrivoltaic IPA = Illinois Power Authority Illinois Adjustable Block Program Voluntary vs. Compliance Markets Net Metering Alternative Compliance Payment Hourly Matching / Time-based RECs Energy Storage and RECs Co-benefits (Pollinator, Water Quality, Tribal Lands, Localized Benefits) Market-based Mechanisms for Clean Energy MISO = Midcontinent Independent System Operator Nuclear Certificates / Alternative Energy Certificates Greenhouse Gas Protocol (Annual vs. Hourly Accounting) Software Development for Clean Energy Tracking Third-party Certification and Attribute Tracking Clean Energy Standards PPA = Power Purchase Agreement State-by-State REC/SREC Programs   Reach out to Ben Gerber & Rob Davis here: Ben's LinkedIn: www.linkedin.com/in/benjamin-gerber Ben's Email: ben@cleancounts.org Rob's LinkedIn: www.linkedin.com/in/robdavis Rob's Email: rob@cleancounts.org Website: www.cleancounts.org   Learn more at www.solarSEAN.com and be sure to get NABCEP certified by taking Sean's classes at www.heatspring.com/sean www.solarsean.com/pvip www.solarsean.com/esip  

This drug has been misunderstood for decades, and that confusion is costing people focus, learning speed, and cognitive performance. In this episode, you'll learn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Renteln, Co Founder and CEO of LUCY Nicotine, a company pioneering science led alternatives for adult nicotine users who want better options. Before launching LUCY, David was also a co founder of Soylent, where he helped pioneer new approaches to functional nutrition and metabolism. Together, Dave and David break down how nicotine works in the brain through acetylcholine and dopamine, why speed of absorption determines addiction risk, and how nicotine affects learning, memory, motivation, and mood. The conversation also covers sleep optimization, mitochondrial signaling, tolerance, cycling strategies, and why modern regulation often slows innovation in functional medicine, anti aging science, and human performance.You'll Learn: • Why nicotine itself is not the same as smoking or vaping • How delivery speed changes addiction risk and brain response • How nicotine supports learning, focus, and neuroplasticity • Why acetylcholine matters for memory and brain optimization • How to think about dosing, cycling, and tolerance safely • How nicotine stacks with caffeine, nootropics, and Danger Coffee • The relationship between nicotine, sleep architecture, and REM • Why harm reduction matters for longevity and mitochondrial health • How nicotine fits into a Smarter Not Harder biohacking strategy Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! -Lucy! Get a 20% discount by using code ‘Dave' at https://lucy.co/# Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nicotine podcast, nicotine nootropic, oral nicotine benefits, nicotine brain optimization, nicotine acetylcholine dopamine, nicotine learning memory, nicotine addiction risk, nicotine pouches vs smoking, LUCY nicotine, david renteln lucy, david renteln nicotine, lucy nicotine pouches, harm reduction nicotine, nicotine biohacking, nicotine human performance, nicotine longevity, nicotine neuroplasticity, nicotine sleep optimization, nicotine tolerance cycling, caffeine nicotine stack, danger coffee nicotine, dave asprey nicotine, dave asprey lucy, nootropics nicotine, functional medicine nicotine Resources: • HeartMath | Go to https://www.heartmath.com/dave to save 15% off. • LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:10 – Origin Story 2:20 – Product Forms & Usage 3:52 – Effects & Mechanisms 9:21 – Dosing & Addiction 15:33 – Memory & Cognitive Benefits 18:57 – Personality & Stacking 21:41 – Quitting Smoking 24:39 – Government Regulation 32:00 – Addiction Philosophy 35:30 – Behavior Change & Routines 39:08 – Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the Flex Diet Podcast, I'm joined by my good friend Dr. Eric Trexler, exercise scientist, educator, and Director of Education at Stronger by Science, for a wide-ranging, no-BS conversation on what physiology actually looks like in the real world.We dig into beetroot juice, nitric oxide, and “pump” supplements, why the blood-flow story is usually oversold, and why neuromuscular function and calcium handling may matter far more than chasing a swollen muscle. We also talk about why most supplement mechanisms sound great on paper… and quietly fall apart once you look at healthy humans who already function pretty well.From there, the conversation expands into human variability, elite athletic outliers, and why normal distributions actually guarantee that “freaks” exist — whether people are comfortable admitting it or not. We also unpack NEAT, energy expenditure, and why exercise doesn't scale linearly for fat loss, including how the body aggressively manages its energy budget when stress or activity gets too high.If you care about performance, body composition, or just understanding how the human system really works, this episode will recalibrate a lot of assumptions.Sponsors:LMNT: http://drinklmnt.com/mikenelson (automatically applied at checkout)Fitness Insider Newsletter: https://miketnelson.com/Shiftwave: https://shiftwave.co/drmiketnelsonEpisode Chapters:05:01 Diving into Beet Root and Nitrate Research05:58 Mechanisms and Effects of Nitrate Supplements10:14 Challenges and Insights in Supplement Research34:19 Elite Athletes and Physiological Variability43:16 Debating the Value of Outliers in Research44:38 The Importance of Studying Rare Genetic Conditions45:46 Challenges in Grant Writing for Rare Conditions47:39 Blood Flow and Muscle Performance49:14 The Science Behind Muscle Pumps and Hypertrophy56:09 Energy Expenditure and Physical Activity58:02 The Non-Linear Relationship Between Activity and Energy Intake01:01:28 Exercise, Appetite, and Weight Management01:14:19 Balancing Cardio and Strength Training for Optimal Health01:21:14 Closing Remarks and Resources Episodes You Might Enjoy:Episode 352: Dr. Dan Pardi on Stem Cells, Supplements, and the Future of Health with QualiaYouTube: https://youtu.be/8EZcHy_7wK8?si=aNGzT-abP9xbc6yUEpisode 343: Fueling the Corporate Athlete: Stress, Supplements & Performance with Dan HunterYouTube: https://youtu.be/0ek4XSs62RQ?si=czR_7q96jJDqXzcFConnect with Eric:Instagram: https://www.instagram.com/trexlerfitnessGet In Touch with Dr Mike:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

Brain Mechanisms of Change in Addiction Treatment: Models, Methods, and Emerging FindingsIn this episode, Dr. Jud explores groundbreaking insights into the brain mechanisms underlying addiction treatment. Drawing on models, methods, and findings presented at the 2015 Science of Change meeting, this research bridges neuroscience and psychotherapy to identify brain processes driving behavior change. Topics include the role of neuroimaging in understanding addiction treatments like CBT, mindfulness, and motivational interviewing, as well as how these insights pave the way for personalized, neuroscience-informed interventions.Reference: Chung, T., Noronha, A., Carroll, K. M., Potenza, M. N., Hutchison, K., Calhoun, V. D., ... & Brewer, J. A. (2016). Brain Mechanisms of Change in Addiction Treatment: Models, Methods, and Emerging Findings. Current Addiction Reports, 3(4), 332-342. DOI: 10.1007/s40429-016-0113-zLet's connect on Instagram

We kick off the 8th season of the All Things Sustainable podcast by diving into the outlook for carbon markets.  For the first episode of the new season we sit down with several guests on the sidelines of the S&P Global Energy Global Carbon Markets Conference, which took place in Barcelona in December 2025.   We hear how the latest regulatory developments are expected to boost demand in 2026. We learn about the impact of innovation and AI on the market's development. And we hear how carbon markets can act as a tool for companies in developing their decarbonization strategies.   We speak to:   Mandy Rambharos, the CEO of Verra, the world's largest issuer of carbon credits and a standard setter for voluntary credits. She explains how key rules and guidelines for international carbon trading under Article 6 of the Paris Agreement on climate change are affecting the market;   Euan McDougall, the CEO of DelAgua, a Rwanda-based developer of carbon projects. He discusses other frameworks overseeing the issuance of carbon credits, including CORSIA, the Carbon Offsetting and Reduction Scheme for International Aviation;    Tomas Thyblad, Vice President of Carbon and Sustainability Solutions at Nasdaq. He tells us how he expects innovation and AI to impact carbon markets;  Juan Carlos Gómez, Principal Manager at ACCIONA Carbon Technologies, a division of Spanish infrastructure firm ACCIONA. He explains the role carbon markets play in ACCIONA's decarbonization strategy;   Olivia Albrecht, CEO of carbon investment management firm Artemeter, which worked with football club FC Barcelona on a project using carbon offsets to reduce emissions related to a stadium rebuild;   And Ingo Ramming, Head of Carbon Markets at Spanish bank BBVA. He explains how the EU's Carbon Border Adjustment Mechanism (CBAM) will impact carbon markets after becoming fully applicable Jan. 1.   Listen to our previous coverage on carbon markets:   What to expect from carbon markets in 2025  After COP29, what's next for carbon markets  Exploring the role of carbon markets in reaching climate targets  What's next for voluntary carbon markets   Copyright ©2026 by S&P Global      DISCLAIMER       By accessing this Podcast, I acknowledge that S&P GLOBAL makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast. The information, opinions, and recommendations presented in this Podcast are for general information only and any reliance on the information provided in this Podcast is done at your own risk.      Any unauthorized use, facilitation or encouragement of a third party's unauthorized use (including without limitation copy, distribution, transmission or modification, use as part of generative artificial intelligence or for training any artificial intelligence models) of this Podcast or any related information is not permitted without S&P Global's prior consent subject to appropriate licensing and shall be deemed an infringement, violation, breach or contravention of the rights of S&P Global or any applicable third-party (including any copyright, trademark, patent, rights of privacy or publicity or any other proprietary rights).     This Podcast should not be considered professional advice. Unless specifically stated otherwise, S&P GLOBAL does not endorse, approve, recommend, or certify any information, product, process, service, or organization presented or mentioned in this Podcast, and information from this Podcast should not be referenced in any way to imply such approval or endorsement. The third party materials or content of any third party site referenced in this Podcast do not necessarily reflect the opinions, standards or policies of S&P GLOBAL. S&P GLOBAL assumes no responsibility or liability for the accuracy or completeness of the content contained in third party materials or on third party sites referenced in this Podcast or the compliance with applicable laws of such materials and/or links referenced herein. Moreover, S&P GLOBAL makes no warranty that this Podcast, or the server that makes it available, is free of viruses, worms, or other elements or codes that manifest contaminating or destructive properties.   S&P GLOBAL EXPRESSLY DISCLAIMS ANY AND ALL LIABILITY OR RESPONSIBILITY FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, CONSEQUENTIAL OR OTHER DAMAGES ARISING OUT OF ANY INDIVIDUAL'S USE OF, REFERENCE TO, RELIANCE ON, OR INABILITY TO USE, THIS PODCAST OR THE INFORMATION PRESENTED IN THIS PODCAST.

In this essential episode of the Prolonged Field Care (PFC) Podcast, host Dennis sits down with CRNA Kevin to dive deep into one of the most overlooked yet critical issues in trauma care: Hypothermia prevention and management. Even in warm environments, trauma patients can rapidly become hypothermic—leading to coagulopathy, increased bleeding, wound infections, and worse outcomes. Dennis and Kevin break down the science, real-world lessons from deployments, and practical strategies for austere and prolonged field care settings.Whether you're a medic, provider, or anyone involved in combat casualty care, this episode will change how you approach keeping patients warm under fire or in remote locations.Episode Highlights:The four main mechanisms of heat loss: radiation (40-60% of total loss), convection, conduction, and evaporation—and how to counter each one effectively.Why even healthy patients cool rapidly under anesthesia, and why trauma patients in the field are at much higher risk.Practical tips for austere environments: using tents, inflatable structures, insulation from the ground, wool blankets, and body heat to raise ambient temperature.Common mistakes that actively cool patients: wet clothing, cold airways (LMAs/ventilation), uncovered exposure, and cold blood/fluid administration.Best bang-for-buck interventions: covering the head, minimizing exposure, drying the patient, using HME filters, and insulating from the ground.Real deployed experiences: keeping trauma bays warm, pre-warming gear, using camping pads on litters, and limitations of Ready-Heat and HPMKs at altitude or in extreme cold.Advanced rewarming techniques (when available): fluid warming, bladder lavage, peritoneal lavage, and ECMO.Temperature monitoring challenges in the field: esophageal, nasopharyngeal, rectal, Foley, and forehead strips—plus how to interpret trends.Chapters:00:00 – Introduction & Why Hypothermia Matters in Trauma Care02:30 – Heat Loss in Anesthesia: Vasodilation and the First-Hour Temperature Drop04:50 – Mechanisms of Heat Loss: Radiation, Convection, Conduction, Evaporation07:10 – OR Strategies: Room Temperature, Head Covering, Fluid Warming, Bear Huggers09:29 – Environmental Control in the Field: Raising Ambient Temperature & Reducing Wind11:52 – Using Tents and Structures to Trap Body Heat14:14 – Insulation from the Ground: Litters, Wool Blankets, Camping Pads, Air Mattresses17:53 – Preventing Conduction & Pressure Sores with Padding19:56 – Avoid Actively Cooling Patients: Cold LMAs, Unheated Ventilation, Wet Clothing22:21 – Heat Moisture Exchangers (HME) & Humidified Gas26:40 – Blood Resuscitation: Cold Fluids vs. Hypovolemia—What Kills First?31:17 – Team-Based Rewarming: Minimize Exposure, Pre-Warm Gear, Dry HPMKs35:22 – Limitations of Battery-Powered Warmers & Bear Huggers in Austere Settings40:04 – Prevention First: Insulate, Cover, Dry—Then Active Rewarming Works Better42:24 – Downstream Effects of Hypothermia: Lethal Triad & Wound Infections44:51 – Aggressive Rewarming Options: Chest Tubes, Gastric/Bladder Lavage, ECMO47:15 – Temperature Monitoring in the Field: Probes, Strips, and Trend InterpretationFor more content, go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.prolongedfieldcare.org⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Consider supporting us: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠patreon.com/ProlongedFieldCareCollective⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ or ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.lobocoffeeco.com/product-page/prolonged-field-care⁠⁠

What if the secret to solving your organization’s toughest problems was thinking like a 10-year-old? Discover how childlike creativity and fun can reframe complex business challenges, spark innovation, and drive real results. Topics Covered: Childlike thinking for organizational problem-solvingPlayful penalties to boost accountabilityStorytelling and translating complex issues for kidsChange management through unbiased perspectivesDementia care and deepfake technology solutionsMechanisms for creativity: no rules, have fun, do good, no shameDesigning inclusive, impactful brainstorming sessionsBridging playfulness and business gravitasApplying kid-inspired thinking to AI and executive decisionsKeeping curiosity and creative practice alive in organizations Connect with Bas Warmerdam:ConsultingKids.comLinkedIn Episode Chapters00:00:05 – Welcome & Intro to the Tech Humanist Show00:00:17 – “Playful Penalties” concept and team accountability00:00:41 – Bas Warmerdam's work with Consulting Kids00:01:50 – Approach and methodology using children as junior consultants00:03:38 – Reframing collaboration problems through childlike solutions00:04:24 – Implementing playful penalties and organizational impact00:06:02 – The “Thinking Like a Child for Professionals” process00:08:27 – Bringing executives into the classroom and change management benefits00:09:23 – Storytelling for complex issue translation00:12:14 – Mechanisms for leaders to use childlike thinking in their teams00:15:09 – Four key thinking mechanisms from kids00:15:50 – Example: Dementia care and “no rules” thinking00:18:28 – How professionals can integrate fun and purpose00:19:55 – Embracing “no shame” in creative business solutions00:20:41 – Creating inclusion for quiet and underrepresented voices00:22:03 – Reintegration: Bringing creative ideas into business practice00:24:21 – Childlike thinking for AI-related decisions00:26:55 – Using kid-driven creativity to challenge AI authority00:28:40 – Sustaining childlike thinking post-consulting00:30:41 – Keeping curiosity sharp and connecting at home00:32:19 – How to connect with Bas Warmerdam and Consulting Kids00:32:55 – Closing remarks and credits

Muscle hypertrophy is one of the most researched topics in exercise science. And yet, it's still one of the most misunderstood.In this episode, I'm joined by exercise scientist and researcher Derrick Van Every, author of the 2025 review Load-Induced Human Skeletal Muscle Hypertrophy: Mechanisms, Myths, and Misconceptions, to separate what actually drives muscle growth from what simply shows up alongside hard training.Together, we break down the human evidence, challenge long-standing myths, and clarify how lifters and coaches should actually approach hypertrophy-focused training.In this episode, we cover:MECHANICAL TENSION AS THE PRIMARY DRIVER OF HYPERTROPHYWHAT ROLE IF ANY DOES METABOLIC STRESS PLAY IN MUSCLE GROWTHDOES THE PUMP CONTRIBUTE TO MUSCLE GROWTH?DO ACUTE CHANGES IN HORMONES FROM TRAINING INFLUENCE HYPERTROPHY OUTCOMESHOW SHOULD WE APPROACH TRAINING TO MAXIMIZE MUSCLE HYPERTROPHY?If you want a clear, evidence-based understanding of how muscle is actually built and how to structure your training around the variables that matter most, this conversation will bring clarity.WHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/For Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiryEmail: Bdacruzfitness@gmail.comBrandon's Website: https://www.brandondacruzfit.com

This episode explores the evolving role of ketamine in mental health care and what it means for the future of nursing practice as psychedelic-assisted therapies move toward mainstream medical use. Rebecca Ivory, DNP, MS, PMHNP-BC, Adjunct Faculty at the University of Delaware School of Nursing in Newark, Delaware, and Jennifer Graber, EdD, APRN, PMHCNS-BC, Associate Dean at the University of Delaware School of Nursing, co-authors of the NCPD article, "Ketamine infusion therapy for treatment-resistant major depressive disorder and suicidal ideation: Nursing care and considerations,"published in the December 2025 issue of Nursing share their insights.

Dr. Randy Blakely is a Professor of Biomedical Science at Florida Atlantic University and Executive Director of the Florida Atlantic University Brain Institute. Randy is examining how neurons control neurotransmitter signaling, as well as how medicinal drugs and drugs of abuse impact neurotransmitters. He is interested in how normal neurotransmitter regulation and changes in neurotransmission due to drugs ultimately impact behavior. Randy lives in beautiful South Florida near the Everglades, and he likes to spend is free time enjoying nature and observing the local wildlife. While commuting between campuses, Randy listens to a variety of audiobooks, and he is also a big fan of Americana and folk music. He received his B.A. in Philosophy from Emory University and his Ph.D. in Neuroscience from the Johns Hopkins School of Medicine. He next conducted postdoctoral research at the Yale/Howard Hughes Medical Institute Center for Molecular Neuroscience. Randy was an investigator and faculty member at Emory University and Vanderbilt University before accepting his current position at Florida Atlantic University. Randy is the recipient of numerous awards and honors for his research and mentorship. He was awarded the Daniel Efron Award from the American College of Neuropsychopharmacology, two Distinguished Investigator Awards from the Brain and Behavioral Research Foundation, a MERIT Award from the National Institute of Mental Health, a Zenith Award from the Alzheimer's Association, the Delores C. Shockley Partnership Award in recognition of minority trainee mentorship, as well as the Astellas Award in Translational Pharmacology and the Julius Axelrod Award both from the American Society for Pharmacology and Experimental Therapeutics. In addition, he is a Fellow of the American Academy for the Advancement of Science. Randy joins us in this episode to talk more about his life and science.

https://youtu.be/rujLg6Xp5WQ

Abby and Patrick welcome psychoanalyst and clinical social worker Brian Ngo-Smith for a conversation about one of the most difficult but powerful concepts in psychoanalytic theory: projective identification. A notion that demands simultaneously thinking about infantile development and adult behaviors, normal defenses and pathological patterns, the idea of projective identification captures an essential dimension of all kinds of interpersonal relationships – but it also throws some of our most basic assumptions about the distinction between self and other into question. In the first of a two-part series, Brian, Abby, and Patrick unpack the concept of projective identification, setting it in historical context, and considering it from a variety of perspectives. They explore topics including classical Freudian versus object relations approaches to development; the works of Melanie Klein and Wilfred Bion; the defense mechanisms in general and ideas of projection and introjection specifically; projective identification in therapy, romantic partnerships, and professional life; and more. In part II, which comes out next Saturday, Brian, Abby, and Patrick put the idea of projective identification to work in considering group behavior, institutional cultures, and politics.Texts cited:Melanie Klein, “Notes on Some Schizoid Mechanisms” Wilfred Bion, Experiences in GroupsTeresa Brennan, The Transmission of Affect Nancy McWilliams, Psychoanalytic Diagnosis: Understanding Personality Structure in the Clinical ProcessJL Mitrani, “'Taking the transference': Some technical implications in three papers by Bion”Anna Freud, The Ego and the Mechanisms of DefenseJerome Blackman, 101 Defenses: How the Mind Shields ItselfMore about Brian at https://ngosmiththerapy.com/ and https://ngosmithconsulting.comOur previous episode with Brian, “Hate, Help, and Housing: Psychoanalysis and Social Work”: https://ordinaryunhappiness.buzzsprout.com/2131830/episodes/14213981-36-hate-help-and-housing-psychoanalysis-and-social-work-feat-brian-ngo-smithHave you noticed that Freud is back? Got questions about psychoanalysis? Or maybe you've traversed the fantasy and lived to tell the tale? Leave us a voicemail! (646) 450-0847  A podcast about psychoanalysis, politics, pop culture, and the ways we suffer now. New episodes on Saturdays. Follow us on social media:  Linktree: https://linktr.ee/OrdinaryUnhappiness Twitter: @UnhappinessPod Instagram: @OrdinaryUnhappiness Patreon: patreon.com/OrdinaryUnhappiness Theme song: Formal Chicken - Gnossienne No. 1 https://open.spotify.com/album/2MIIYnbyLqriV3vrpUTxxO Provided by Fruits Music

This week on the WHOOP Podcast, WHOOP Global Head of Human Performance, Principal Scientist, Dr. Kristen Holmes sits down with dual-sport national team athlete and exercise physiologist Dr. Heather Logan-Sprenger. The two take a deep dive into one of the most underrated and often forgotten about habits for human performance: hydration.Dr. Logan-Sprenger shares how growing up in Northern Ontario, watching her dad water flowers and her cat grow winter fur, quietly planted the seeds for a lifelong fascination with physiology, stress, and adaptation. From competing for Team Canada in both ice hockey and road cycling to suffering from heat stroke mid–PhD on hydration, her experience and education show just how fragile — and adaptable — the human body really is.Dr. Holmes and Dr. Logan-Sprenger identify what mild dehydration does to your metabolism, brain, and overall performance, and how hydration needs shift across the menstrual cycle. This episode will teach you the simple hydration strategies, how to calculate your sweat rate at home, and when electrolytes actually matter.(01:07) Dr. Heather Logan-Sprenger Intro: Background in Sport & Physiology(01:49) Training, Nutrition, & Hydration: Unpacking Your Body's Needs(08:06) National-Level Athlete to PhD(10:51) WHOOP Podcast Rapid Fire Questions(13:08) Training At Altitude: Hydration Dos and Don'ts (14:49) The Physiology of Heat Stroke(20:33) Correlation Between Hydration and Carbs While Training(24:51) How The Menstrual Cycle Affects Hydration (31:19) Mechanisms of Dehydration: What Happens To The Body(36:52) Cognitive Disadvantages Of Dehydration(38:56) Dehydration's Effects On The Cardiovascular & Thermoregulatory System(40:35) Dehydration's Effects On The Brain (41:29) Measuring Your Sweat Rate As An Athlete(45:39) Essential Habits To Teach Kids and Athletes About Hydration(49:20) Overhydrating and Mineral Loss with Hydration(53:45) Debunking Hydration Myths(55:54) Heart Rate, Lactate, and Power Output's Relationships to Hydration(59:48) Dr. Logan-Sprenger's Ideal Hydration Study: Mitochondrial Hypoxia and Metabolism(01:05:23) OutroFollow Dr. Heather Logan-SprengerLinkedInInstagramPeakgenicsSupport the showFollow WHOOP: Sign up for WHOOP Advanced Labs Trial WHOOP for Free www.whoop.com Instagram TikTok YouTube X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

Ketamine is a dissociative anesthetic that provides powerful analgesia while preserving spontaneous ventilation, airway reflexes, and sympathetic tone, which makes it especially valuable in trauma, bronchospasm, difficult airways, and in patients with high opioid tolerance. As a phencyclidine derivative with a chiral center, it exists as two enantiomers, with S-ketamine roughly twice as potent as R-ketamine and associated with fewer unpleasant emergence reactions, while its pKa and balanced water–lipid solubility allow rapid CNS penetration and redistribution-limited offset. Its multimodal mechanism centers on noncompetitive NMDA antagonism but also includes opioid receptor modulation, catecholamine reuptake inhibition, AMPA receptor effects, ion channel blockade, muscarinic antagonism, and anti-inflammatory actions, all of which underpin clinical dosing strategies for induction, maintenance, procedural sedation, and analgesic infusions as well as key considerations around emergence delirium, secretions, cardiovascular status, and ICP.Want to learn more? Grab our Cardiac Pharm Course --> [HERE]⚛️ CONNECT:

We've gathered the NaPS lab to answer all your fascinating questions on all things sleep! A perfect bitesize episode to get stuck into the marvellous world of sleep. 1. How does sleep deprivation affect mental health? - Answered by Martha WawrzutaBunney, B. G. , Bunney, W. E. (2013). Mechanisms of Rapid Antidepressant Effects of Sleep Deprivation Therapy: Clock Genes and Circadian Rhythms. Biological PsychiatryFang, H., Tu, S., Sheng, J., Shao, A. (2018). Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. Journal of Cellular and Molecular Medicine2. What is narcolepsy? - Answered by Kyrillos MeshrekyLeschziner G., Narcolepsy: a clinical review, Practical Neurology 2014;14:323-3313. Does the full moon affect sleep? - Answered by Al Saqib MajumderCasiraghi, L. et al. (2021). Moonstruck sleep: Synchronization of human sleep with the moon cycle under field conditions. Chaput, J. P. et al. (2016). Are Children Like Werewolves? Full Moon and Its Association with Sleep and Activity Behaviors in an International Sample of Children. Sleep Medicine4. How does a smart watch track sleep? - Answered by Yan Wang5. What is orthosomnia? - Answered by Sophie Smith Baron, K.G., et al. (2017) Orthosomnia: Are some patients taking the quantified self too far? J Clin Sleep Med6. What is sleep regression and how long does it last? - Answered by Mo AbdellahiWeinraub, M. et al. (2012). Patterns of developmental change in infants' nighttime sleep awakenings from 6 through 36 months of age. Developmental PsychologyBruni O. et al. (2014) Longitudinal study of sleep behavior in normal infants during the first year of life. J Clin Sleep Med7. Does Magnesium Citrate help you sleep? - Answered by Dulni PeramunugamageMagnesium for sleep, Sleep Foundation, 20258. Does dark chocolate help you sleep? - Answered by Martha Nguyen Abdoli, E. et al. (2024). A clinical trial of the effects of cocoa rich chocolate on depression and sleep quality in menopausal women. Scientific reports,Garbarino, S., Garbarino, E., & Lanteri, P. (2022). Circadian Rhythm, Mood, and Temporal Patterns of Eating Chocolate: A Scoping Review of Physiology, Findings, and Future Directions. NutrientsMusic by Sergio Prosvirini from PixabayCheck out our NaPS website to find out more about the podcast, our research and events. This recording is the property of the Sleep Science Podcast and not for resale.

Text Dr. Lenz any feedback or questions The Science Behind Music's Power to Relieve Chronic PainFeeling trapped by chronic pain and dependent on pills? Discover how music can rewire your nervous system and alleviate pain, anxiety, and depression. Join Dr. Michael Lenz as he delves into robust scientific evidence—from randomized controlled trials to systemic reviews—that highlight music's efficacy in treating chronic pain conditions like fibromyalgia. Learn how self-chosen music, through mechanisms involving neurochemicals like beta endorphin and oxytocin, can act as your brain's natural pharmacy. Dr. Lenz provides practical takeaways on harnessing the power of music to activate your body's internal pain relief systems, reduce stress hormones, and improve emotional well-being.Watch on YouTube Here00:00 Introduction: Music as Medicine01:20 Scientific Evidence: Music's Impact on Pain03:31 Mechanisms of Music-Induced Analgesia04:26 Neurochemicals and Pain Relief08:21 Practical Applications and Benefits09:54 Conclusion: Harnessing the Power of Music Support the showWhen I started this podcast and YouTube Channel—and the book that came before it—I had my patients in mind. Office visits are short, but understanding complex, often misunderstood conditions like fibromyalgia takes time. That's why I created this space: to offer education, validation, and hope. If you've been told fibromyalgia “isn't real” or that it's “all in your head,” know this—I see you. I believe you. This podcast aims to affirm your experience and explain the science behind it. Whether you live with fibromyalgia, care for someone who does, or are a healthcare professional looking to better support patients, you'll find trusted, evidence-based insights here, drawn from my 29+ years as an MD. Please remember to talk with your doctor about your symptoms and care. This content doesn't replace per...

Nutrients are usually studied in isolation, yet synapses don't operate that way. This episode examines research showing that coordinated nutritional inputs can reshape synaptic proteins and neural firing patterns (effects that isolated inputs fail to produce). The shift isn't about stronger signaling, but more organized signaling within brain circuits.The goal: explain why biological systems respond to combinations rather than singles, how coordinated inputs influence synaptic receptors, protein synthesis, and network synchronization.00:00 Introduction to Neural Circuit Malfunctions00:39 Understanding Neural Communication01:38 Nutrient Interventions in Neural Circuits02:57 Research Findings on Nutrient Mixtures04:37 Mechanisms of the Mixture06:33 Practical Implications and Dietary Recommendations09:01 Conclusion and Final ThoughtsPMID: 41329641PMID: 38498094PMID: 40910091

PREVIEW — Andrea Stricker — Nuclear Safeguards Framework for Saudi Arabia's Reactor Acquisition. Strickeroutlines essential precautions and international safeguard mechanisms necessary to prevent nuclear proliferation resulting from Saudi Arabia's acquisition of advanced nuclear power plant technology and fuel cycle capabilities. Strickerrecommends permanent International Atomic Energy Agency (IAEA) safeguard protocols and comprehensive additional verification arrangements covering all present and future Saudi nuclear facilities, ensuring Riyadh cannot unilaterally eject IAEA inspectors or rescind international safeguard commitments if the Kingdom subsequently pursues uranium enrichment or nuclear fuel reprocessing activities for weapons development. Stricker emphasizes that binding safeguard protocols are essential to preventing Saudi acquisition of weapons-grade nuclear material and maintaining nonproliferation regime integrity in the Middle East.

Interview with Alfred E. Buxton, MD, and Marie-France Poulin, MD, authors of Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement. Hosted by Kristen K. Patton, MD. Related Content: Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement

Welcome back to the Flex Diet Podcast! Today, I'm hanging out with the brilliant Katie Emerson, Senior Manager of Scientific Affairs over at Kyowa Hakko USA, aka the people behind Cognizin (CDP Choline), one of the few brain-boosting ingredients with legit research behind it.We dig into the real science of CDP Choline, how it supports memory, focus, and cognitive performance, and where it actually fits into the human physiology engine, not the hype machine. Katie and I also zoom out into the supplement industry as a whole, chatting about what's worth paying attention to, what's still emerging, and how to navigate all the shiny promises out there.We even take a nerd-tour into mental resilience, genetic mapping, and the surprising potential of glutathione for health and performance.If you're curious how targeted supplements can help you think faster, recover better, and be a more high-performing human without needing a PhD to decode marketing nonsense, this episode is for you.Sponsors:Flex 4: Katie's top 4 things to know about citocholineEpisode Chapters:03:52 Katie Emerson Joins the Conversation04:09 Conversations at ISSN and Networking11:20 Research and Studies on CDP Choline17:49 Challenges in Supplement Formulation24:40 Mechanisms and Benefits of CDP Choline28:06 Exploring Genetic Mapping and Data Overload29:01 Study Design and Dosing Strategies30:29 The Sweet Spot of CDP Choline Dosage33:40 Pharmacokinetics and Timing of CDP Choline35:36 Safety and Side Effects of High Doses38:59 Comparing CDP Choline and Alpha GPC42:41 Introduction to Glutathione48:41 Oral Absorption of Glutathione52:12 Podcast Conclusion and Listener Information Episodes You Might Enjoy:Episode 343: Fueling the Corporate Athlete: Stress, Supplements & Performance with Dan Hunter YouTube: https://youtu.be/0ek4XSs62RQ Episode 222: Expert Insights on nutrition, supplements, and training with Registered Dietitian Sean CaseyYouTube: https://youtu.be/wjJB-y1kwgMConnect with Katie:Cognizin: cognizin.comGet In Touch:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

Coach Bronson discusses his journey into ketogenic research, emphasizing the importance of understanding metabolic flexibility and the biases present in current studies. He highlights common misinterpretations in research, particularly regarding oxygen consumption and the duration of ketogenic interventions. Bronson also addresses the challenges of washout periods in studies, the significance of electrolyte balance, and the misuse of mechanisms to justify carbohydrate superiority. The discussion aims to provide listeners with a clearer understanding of ketogenic diets and the need for more rigorous research methodologies.Chapters00:00 Introduction and Background02:14 The Evolution of Ketogenic Research05:49 Identifying Biases in Nutritional Studies10:50 Misinterpretation of Oxygen Consumption14:43 Understanding Movement Economy29:36 Challenges in Defining Ketogenic Adaptation39:41 The Problem with Washout Periods44:10 The Loss of Curiosity in Nutrition Science45:55 Reanalyzing Existing Data in Nutrition49:01 Physiological Resilience and Athletic Performance52:06 The Importance of Study Duration in Research53:58 Performance Claims vs. Actual Data56:50 Misinterpretation of Ketogenic Diet Studies01:01:01 The Role of Electrolytes in Low-Carb Diets01:12:00 Mechanisms of Carbohydrate Superiority

PREVIEW — David Daoud — Hezbollah's Ideological Bond and Financial Secrecy. Daoud explains that Hezbollah'sfinancial structures remain systematically opaque and untraceable, as the organization utilizes clandestine fundraising mechanisms and independent revenue streams rather than relying exclusively upon Iranian material support and financial transfers. Daoud characterizes the "genius" of the Hezbollah-Iran relationship as fundamentally ideological rather than transactional; Hezbollah maintains unwavering loyalty to Tehran rooted in shared religious conviction and revolutionary philosophy, meaning the organization would remain strategically faithful to Iran even if material support and financial subsidies were terminated, creating durable strategic partnership independent of fluctuating resource availability. 1960 BEIRUT

Sen and Erica welcome Sarah Shipp, guest host of Thinking Beyond Mechanisms, to talk about some of the ways in which theme can be measured and how that affects game design.

Drew Perkins welcomes neuroscientist and acclaimed author Jared Cooney Horvath to dissect his new book, The Digital Delusion, which provides a rigorous, evidence-based critique of edtech. Links & Resources Mentioned In This Episode Horvath doesn't mince words, arguing that the majority of student-facing, internet-connected devices should be removed from schools. He reveals that over 60 years of consistent data supports his claim that the integration of digital tools is fundamentally detrimental to effective learning. This isn't a Luddite's complaint; it's a detailed exploration of the Neuroscience of Learning. The harm is explained through three primary biological mechanisms, which Horvath asserts are unfixable with software. First, screens train students to multitask, leading to a constant, detrimental battle for attention in a learning environment. Second, the use of devices inhibits the essential human-to-human interaction necessary for empathetic synchrony—the mirroring and mimicking critical for deep cognitive and social development. Finally, we discuss the profound problem of Transfer of Learning. Horvath explains that by learning skills in an "easy" digital context, the ability to transfer that knowledge to a more complex, real-life (analog) task is significantly diminished, making the learning "slower, worse, and less deep." The data suggests tech only works in highly narrow contexts, primarily for surface-level "drill and kill" facts or basic remediation, often through intelligent tutors. The conversation then shifts to the persistent educational conflicts, notably the ongoing tension between Explicit Instruction vs Inquiry and Project-Based Learning (PBL). Horvath connects the rigidity of entrenched positions to a "sunk cost" phenomenon, where individuals find it too "costly" to change their public stance, even when facing opposing evidence. We delve into the complexities of teaching, noting that both traditional and progressive approaches are valid at different points in a student's journey, but both are fundamentally flawed when they adhere rigidly to a single philosophy. Furthermore, we explore the nature of Critical Thinking Skills and creativity. Horvath clarifies that while the mechanism for critical thinking is innate across all ages, its output is heavily constrained by the individual's available domain-specific knowledge. The science of learning, he argues, has nothing to say about specific pedagogy (such as direct instruction versus exploratory learning); it only describes the biological constraints of how the brain learns. Therefore, neuroscience should serve as a powerful tool to inform and improve any existing pedagogical approach, not dictate a single one. Horvath offers a vision for the ideal classroom, suggesting elementary spaces should be "basically outdoor," focused on play and minimal tech. For older students, he advocates for a high level of control, confining computer use to specialized lab settings—much like woodshop or physical education. This perspective provides an essential counter-narrative for any K-12 educator or administrator struggling to balance modern tools with effective, long-term student success. To continue exploring innovative, evidence-based strategies, subscribe to the ThoughtStretchers Podcast on your favorite podcast player! Timestamped Episode Timeline Time Segment/Topic [00:00] Introduction of Jared Cooney Horvath – Teacher-turned-neuroscientist, focus on "human learning" and applying neuroscience to educational practices. [01:28] Jared's Educational Background and Views on Pedagogy – Describing his K-12 experience as a "mishmash" that didn't adhere rigidly to "traditional" or "progressive" labels. [03:45] The Digital Delusion Book & EdTech Critique – Introducing the book and its core argument: edtech fundamentally harms learning, advocating for reducing/eliminating non-essential computer use in classrooms. [07:18] EdTech and Learning Outcomes/The Swedish Example – Advocating for removing student-facing, internet-connected devices; citing Sweden's ban on general tech use in schools (confining computers to a lab). [08:09] Exceptions for Technology Use – Tech only works effectively in narrow contexts: self-adaptive "intelligent tutors" for surface-level (drill and kill) learning and remediation. [09:46] Mechanisms of EdTech Harm (Biological) – Outlining the three primary ways screens harm learning: Attention, Empathetic Synchrony, and Transfer. [12:29] Transfer and Complexity in Learning – Discussion on how learning in an easy digital context makes skill transfer to a harder, real-life analog context almost impossible. [15:54] AI, Pedagogy, and Creating Learning Tools – Drew's example of using AI for quizzes; Jared's counter that learning is "slower, worse, and less deep" than if the student created the tools themselves. [18:07] The Ideal Classroom – Jared's vision for elementary (outdoor, play-focused, minimal tech) and middle/high school (human-element focus, highly controlled tech use in a lab). [20:17] Critical Thinking and Metacognition – Discussion on the definition of critical thinking, with Jared suggesting metacognition is a more accurate term for the process. [23:02] The Role of Knowledge in Critical Thinking – The mechanism is universal, but the outcome of critical thinking without knowledge is "very very narrow or pointless." [27:43] Creativity and Questioning – Defining creativity as "rearranging of your current memory structures." The role of knowledge and safety/context in the ability to ask good questions. [35:47] Tension Between Traditional and Progressive Education – Observing the acute conflict in Australia/UK; asserting both approaches are correct at different points but wrong when they are too rigid. [40:34] Science of Learning and Pedagogy – Stressing that the science of learning only concerns biological mechanisms and should inform teaching, not dictate a specific pedagogy. [43:08] AI Model Training and Pedagogical Parallels – Drew's question on parallels between AI's "symbolism" vs. "connectivism" and educational philosophies. [44:15] Critique of AI and Cognitive Models – Jared's view that AI conceptualization has mistakenly influenced brain understanding and that current AI models may be at a peak without a new theoretical framework. [46:02] Book and Contact Information – Sharing website (www.lmegglobal.net), new book (The Digital Delusion), and YouTube channel. [46:47] Closing Remarks – Final thoughts on recognizing the "gray zone" in complex educational issues.  

PREVIEW — Mary Anastasia O'Grady — Lingering Capital Controls Spook Investors in Argentina. O'Grady reports that despite President Milei's substantial deregulation initiatives, lingering Argentine capital control mechanisms continue systematically deterring foreign investors who harbor justified fears regarding restrictions on capital extraction and currency repatriation. O'Grady documents that previous Argentine administrations implemented draconian capital restrictions, deploying customs enforcement mechanisms including canine detection units on Uruguayan river ferries to prevent illegal capital flight. O'Grady emphasizes that investor communities remain chronically cautious regarding potential reimposition of capital controls by future political administrations, creating structural investor hesitation despite Milei's demonstrated commitment to economic liberalization and market-based reforms. 1950 TANGO IN BUENOS AIRES

In this episode of the Green Pill Podcast, Kevin Owocki and co-host Devansh Mehta sit down with Vitalik Buterin for their annual deep dive into the future of public goods funding in the Ethereum ecosystem. They explore where funding will come from in 2026, how the landscape has shifted from "vibes-based" funding to verifiable, dependency-driven mechanisms, and why this is the best moment to reform PGF using new tools like programmable cryptography, AI-assisted evaluation, and deep funding models. Vitalik also shares how he thinks about dependencies, credible neutrality, open-source licensing, pluralism, accountability, and what builders should prioritize in the coming year. A must-listen for anyone designing mechanisms, funding public goods, or building the next era of Ethereum governance.

Socialism Comes to New York — Cliff May — May critiques New York City Mayor-elect Momdani's socialist-oriented policies, arguing that aggressive rent freeze mechanisms systematically diminish housing stock availability, reduce construction incentives, and undermine long-term affordability through supply contraction. May warns that additional socialist initiatives including fare-free public transportation and police defunding drive middle-class residents toward suburban and exurban jurisdictions. May cites Venezuelan economic collapse and continuing socialism failure across multiple jurisdictions as empirical evidence that socialist economic models fundamentally cannot function effectively in complex modern capitalist economies like New York City. 1888 five points

3/4. Price Discovery, Trade Policy, and Government Market Distortions — Terry Anderson (Editor) — Andersondiscusses Timothy Fitzgerald's analysis demonstrating that border carbon adjustment mechanisms frequently disguise protectionist trade policies, aligning with the "bootleggers and Baptists" theoretical model. Anderson stresses that authentic price discovery in financial markets is absolutely crucial for effective climate adaptation. However, government intervention, including subsidized insurance programs for flood and crop losses, systematically distorts accurate price signals, preventing consumers from developing effective behavioral and economic adaptations to genuine environmental risks. 1905

Today, I am delighted to be joined by a friend and colleague, Mike Mutzel.  Mike has a master's in Clinical Nutrition from the University of Bridgeport. He is a graduate of the IFM, applies functional medicine in clinical practice, and is a consultant lecturer who teaches leading-edge science in a concise format for progressive clinicians to prevent chronic diseases.  In our discussion, Mike and I unpack the benefits of creatine monohydrate, highlighting the importance of ensuring the products we use are free of impurities. We explain how creatine monohydrate gets created, answer many listener questions, and describe current research specific to creatine monohydrate, discussing ways to support bone health, navigate dosing, and how to troubleshoot.  This conversation with Mike Mutzel is truly invaluable, and I look forward to having him back on the podcast to dive a little deeper into the science.  IN THIS EPISODE, YOU WILL LEARN: How creatine supports energy production across muscles, the brain, and other organ systems Why vegetarians and vegans should take creatine What to consider when choosing high-quality creatine supplements Dosing strategies based on diet, exercise, sleep, and individual needs How taking creatine with electrolytes while exercising can improve absorption Benefits of supplementing with amino acids alongside creatine for illness, recovery, or when protein intake is low Adjusting your creatine dosage for sleep, travel, or exercise demands How creatine supports bone and muscle health  The value of creatine for the eyes and ears Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Mike Mutzel On his website YouTube Instagram High Intensity Health Podcast Creatine Research: Creatine in Women's Health: Bridging the Gap From Menstruation Through Pregnancy to Menopause Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial

Jamie and Don, freshly back from PAX Unplugged 2025 in Philadelphia, have been getting into some board, card, and dice rumbles lately, and they wanted to dig into the many styles of combat systems in board games. Deterministic versus random, complex versus streamlined, dice versus cards - there's a lot of ground to cover. Also, our yearly fundraiser is currently running on Kickstarter! Support us now at https://www.thesecretcabal.com/kickstarter

2/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1917

3/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1916

4/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1918

1/8. Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul 1812.

Turn online alignment into an offline community — join us at TheWayFwrd.com to connect with like-minded people near you.Your symptoms aren't random, they're the crime scene of a moment your mind forgot.In this episode, I sit down with Dr. Melissa Sell to explore a biological map born from one doctor's grief, and how sudden emotional shocks, brain-level changes, and tissue adaptations follow a repeating pattern she now sees every day in people's scans and stories. I share two of my own stories – the rash that kept showing up on the right side of my face, and the colon scare that hit during one of the angriest seasons of my life – and how both matched this framework with borderline uncomfortable precision.If you've ever been told your symptoms are random, mysterious, or “just stress,” this conversation offers a very different lens.You'll Learn:[00:00:00] Introduction[00:08:22] Your symptoms are always telling the truth[00:11:04] Dr. Hamer's devastating loss, testicular cancer and the creation of the First Biological Law[00:18:55] What a real conflict shock is and why it's more than just being stressed out[00:25:11] The Five Biological Laws[01:06:29] The arrogance of not respecting, trusting and understanding nature's design[01:18:27] Why Ted Kaczynski's early separation trauma explains his later violent patterns[01:24:15] What happens when territorial anger and identity conflict strike at the same time[01:30:44] Brain layers, hormones, and hierarchy biology[01:44:49] How does our belief impact our physiology and symptoms?[02:02:15] Why doesn't everyone who experiences the same conflict develop symptoms?[02:23:13] Why seizures happen according to German New Medicine[02:37:22] Why do young babies get sick?[02:39:20] Can belief override or amplify the physical effects of harmful or beneficial substances?[02:46:22] Your body is infinitely adaptable, if you're relaxed[02:56:34] Is German New Medicine truly a universal biological law?[03:00:55] What to do when you can't figure out what the conflict was that is causing your symptoms[03:04:30] How to actually resolve your conflicts & why are there some conflicts you might not want to resolve?[03:09:26] When the healing phase would be too intense, surgery is still a good option[03:41:23] How your internal story shapes whether you lean into victimhood or transformation[03:43:29] Similarities between Traditional Chinese Medicine and German New Medicine[03:49:17] What allergies really are[03:59:01] Bringing conflicts into consciousness can offer immediate resolution[04:00:12] Detective work stories of deciphering conflicts and symptoms[04:12:52] Why forcing healing doesn't workResources Mentioned:The Way Forward episode on German New Medicine with Dr. Melissa Sell | Apple or SpotifyDr. Hamer | WebsiteGHK Self Study Bundle | WebsiteUse discount code TWF50 and save $50 off Melissa's course The Bio-Logical Woman starting February 2026.Find more from Dr. Melissa:Dr. Melissa Sell | WebsiteDr. Melissa Sell | YouTubeDr. Melissa Sell | FacebookDr. Melissa Sell | InstagramDr. Melissa Sell | XFind more from Alec:Alec Zeck | InstagramAlec Zeck | XThe Way Forward | InstagramThe Way Forward is Sponsored By:RMDY Academy & Collective: Homeopathy Made AccessibleHigh-quality remedies and training to support natural healing. Enroll hereExplore hereCreate a cleaner energetic space, go to AiresTech.com and use code TWF25 at checkout for 25% off your entire order.New Biology Clinic: Redefine Health from the Ground UpExperience tailored terrain-based health services with consults, livestreams, movement classes, and more. Visit www.NewBiologyClinic.com and use code TheWayForward for $50 off activation. The Way Forward members get the $150 fee waived

Suleika Jaouad was diagnosed with cancer at 22. She made her illness the subject of a New York Times column and a memoir, Between Two Kingdoms. She and Steve talk about what it means to live with a potentially fatal illness, how to talk to people who've gone through a tragedy, and ways to encourage medical donations. SOURCES:Suleika Jaouad, author. RESOURCES:The Book of Alchemy: A Creative Practice for an Inspired Life, by Suleika Jaouad (2025).The Alchemy Journal, by Suleika Jaouad (2025).“The Art of Survival,” by Jennifer Senior (The Atlantic, 2024).American Symphony, film by Matthew Heineman (2023).Between Two Kingdoms: A Memoir of a Life Interrupted, by Suleika Jaouad (2021).“Max Ritvo, Poet Who Chronicled His Cancer Fight, Dies at 25,” by John Schwartz (The New York Times, 2016).“Life, Interrupted,” column by Suleika Jaouad (The New York Times, 2012-2015).The Fault in Our Stars, by John Green (2012).Bright-sided: How Positive Thinking Is Undermining America, by Barbara Ehrenreich (2009).The Isolation Journals, newsletter by Suleika Jaouad. EXTRAS:“John Green's Reluctant Rocket Ship Ride,” by People I (Mostly) Admire (2022).“Does Death Have to Be a Death Sentence?” by People I (Mostly) Admire (2022). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.