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Sen and Erica welcome Sarah Shipp as she hosts her Thinking Beyond Mechanism series. In this episode, she discusses the permissions that games and their rules give us to break social conventions within the construct of the so-called "Magic Circle".
Between The Lines Radio Newsmagazine podcast (consumer distribution)
CODEPINK World Court Campaign Coordinator Robert Jereski: After Gaza Hostage/Prisoner Exchange, Ceasefire Lacks Enforcement MechanismsU.S. Marine veteran Bryce Lockwood: Recounting Israel's 1967 Attack on U.S. Research Ship during Six-Day War and Its Lasting ImpactFormer health insurance executive turned whistleblower Wendell Potter: Federal Government Shutdown Exposes Crisis in Long Failing U.S. Healthcare SystemBob Nixon's Under-reported News Summary• Brazil's Jair Bolsonaro, convicted of coup plot, running out of options• Russia, Vietnam can avoid U.S. sanctions with backdoor energy enterprise• Puerto Ricans' mutual aid food system could be a model post-natural disastersVisit our website at BTLonline.org for more information, in-depth interviews, related links and transcripts and to sign up for our BTL Weekly Summary. New episodes every Wednesday at 12 noon ET, website updated Wednesdays after 4 p.m. ETProduced by Squeaky Wheel Productions: Scott Harris, Melinda Tuhus, Bob Nixon, Anna Manzo, Susan Bramhall, Jeff Yates and Mary Hunt. Theme music by Richard Hill and Mikata.
Cancer now affects 30% to 50% of Americans, a massive increase from just 5% in 1900, reflecting how modern diets and lifestyles have reshaped your body's internal terrain Excess linoleic acid (LA) from seed oils triggers toxic byproducts, chronic inflammation, and mitochondrial breakdown, all of which weaken your body's defenses and fuel tumor growth Lowering LA intake from 7% to around 2% to 3% of daily calories has been shown to cut oxidative stress markers by 20% in as little as 12 weeks, giving your body a chance to recover A four-phase terrain restoration strategy uses seed oil elimination, staged carbohydrate reintroduction, gradual fiber restoration, and metabolic supports like intermittent fasting and exercise to rebuild resilience Simple daily steps — avoiding seed oils, rebuilding gut health, supporting mitochondria through movement and sleep, and tracking progress — give you control over your risk and long-term health
Sodium bicarbonate is one of the most consistently supported ergogenic aids in sports nutrition research, yet its underlying mechanisms and real-world applications remain widely misunderstood. More recent developments have focused on how to optimise both the timing and formulation of supplementation. The “individualised ingestion timing” approach has emerged as a practical strategy, recognising that the time-to-peak blood bicarbonate concentration varies considerably between individuals. Similarly, novel formulations are being explored to address issues with gastrointestinal distress and practicality of dosing. These include topical approaches such as sodium bicarbonate lotion, and commercial products like Maurten's “Bicarb System.” In this episode, Prof. Lewis Gough joins to discuss the latest evidence on sodium bicarbonate and performance, its mechanisms, novel delivery systems, and the key directions for future research. Dr. Lewis Gough is Associate Professor in Nutrition and Physiology at Birmingham City University. He is globally recognized for his research on sodium bicarbonate supplementation in sport, and his work spans applied sport and exercise nutrition, exercise metabolism, acid–base balance, and fatigue. Timestamps [03:12] Professor Gough's academic journey [06:29] Mechanisms of sodium bicarbonate and historical perspective on lactate [11:21] Sodium bicarbonate's role in performance [22:45] Individual responses to sodium bicarbonate [26:53] Timing strategies for sodium bicarbonate [32:38] Individualized approach to sodium bicarbonate timing [36:47] Traditional vs. novel delivery methods [44:27] Practical recommendations for athletes [51:18] Future research directions [01:02:08] Key Ideas segment Resources Go to episode page (w/ links to relevant studies) Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course See all of Sigma's "Recommended Resources"
Sam Miller is a respected educator and authority on metabolism and founder of Metabolism School. Sam guests on my podcast to share his expertise on:-The implications of the dramatic rise in GLP-1 Agonist medication use -The situations where GLP-1 Agonist medication use makes sense and where it's inappropriate -Potential benefits outside appetite suppression and weight loss-Nuance about the potential side effects -The importance of strength training when using these drugs-Reverse dieting, what it is, when it's appropriate -Situations where reverse dieting may be harmful -The role ultra processed foods play in the obesity and metabolic unhealth epidemic -Are all ultra processed foods problematic-And much more00:30 GLP-1 Medications: Popularity and Usage01:33 Mechanisms and Effects of GLP-103:10 Broader Implications and Side Effects11:26 Resistance Training and Muscle Preservation17:44 Nuances of GLP-1 Use in Different Populations27:15 Famous Athletes and Weight Struggles27:41 The Trend of Reverse Dieting28:39 Concerns with Reverse Dieting30:57 Effective Reverse Dieting Strategies43:11 The Role of Ultra-Processed Foods in Health51:58 Conclusion and ResourcesI've been putting a lot of time and effort into making these new episodes valuable for you. You can help me get these great guests and their knowledge in front of more people by:-Subscribing and checking out more episodes-Sharing on your social media (please tag me - I promise I'll respond)-Sharing with the friend you think of who needs this episodeFollow Andrew Coates:Instagram:@andrewcoatesfitnessJoin My Email List:www.andrewcoatesfitness.comGet the RP App at www.rpstrength.com/coates - use the code COATESRPUse Code ANDREWCOATESFITNESS to save 10% off at https://justbitememeals.com/Use MacrosFirst for tracking nutrition https://www.macrosfirst.com/Go to www.knkg.com/Andrew59676 for 15% off your KNKG bag.Get a discount on Versa Gripps at www.versagripps.com/andrewcoates
In this episode, Dr. Shaun Jackson uses a compelling patient case to illuminate the complex mechanisms of immune tolerance and autoimmunity. He explains how B cells learn to avoid targeting the body's own tissues through central and peripheral tolerance—and how these safeguards can fail. The discussion covers the roles of germinal centers, T cells, and rare genetic disorders in shaping immune regulation, with Alport's syndrome and post-transplant Goodpasture's disease serving as striking examples. Dr. Jackson also reflects on emerging directions in autoimmune research and shares his journey from medical training in South Africa to leading a research program in Seattle, offering valuable insights for future physician-scientists.
Professors Bas Bloem and Werner Poewe explore the underlying mechanisms of Parkinson's disease and discuss current and emerging therapeutic approaches. A clear and insightful conversation for anyone seeking to better understand the science behind PD and its treatment.
Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Timestamps00:00 Introduction and Video Overview00:14 Oxytocin and Its Connection to Fat Loss01:16 Scientific Data and Research on Oxytocin02:30 Mechanisms of Oxytocin in Fat Loss04:23 Oxytocin's Effects on Appetite and Metabolism05:29 Comparing Oxytocin with Other Weight Loss Aids10:37 Direct Actions of Oxytocin on Fat Cells11:59 Animal and Human Studies on Oxytocin19:26 Oxytocin Usage Protocols24:33 Potential Side Effects and Safety26:56 Conclusion and Final ThoughtsJoin me, Hunter Williams, as I delve into the fascinating connection between oxytocin—the 'love hormone'—and its surprising benefits for fat loss. Discover the scientific data and practical insights that show how this peptide hormone can enhance muscle preservation, improve metabolism, and reduce cravings for high-fat foods. Learn the optimal ways to use oxytocin, including dosing protocols and the synergy with diet and exercise. Don't forget to stay connected by joining my email list for updates on new videos and content. Let's dive in and explore how oxytocin can support your fitness and wellness journey!
Featuring an interview with Dr Ghayas Issa, including the following topics: Mechanism of action and efficacy of menin inhibitors (0:00) Presentation and management of differentiation syndrome (13:31) Role of menin inhibitors in other cancers (18:19) Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51) Mechanisms of resistance to menin inhibition in AML (26:53) Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31) Mechanism of action of menin inhibitors as differentiation agents (38:05) Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55) Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25) Other investigational therapeutic strategies in AML (54:39) CME information and select publications
Featuring a slide presentation and related discussion from Dr Ghayas Issa, including the following topics: Evolution of menin inhibitors for acute myeloid leukemia (AML) (0:00) Side effects of menin inhibition (10:54) Mechanisms of resistance to menin inhibition in AML (15:08) CME information and select publications
Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/00:00 Introduction and Video Overview00:20 Personal Experience with SS 3101:43 Scientific Basis and Human Trials03:25 Mechanisms of SS 3107:37 Clinical Applications and Benefits14:46 Dosing Guidelines and Safety21:21 Emerging Applications and Future Potential26:51 Conclusion and Final ThoughtsIn this comprehensive deep dive into SS-31, I'll be sharing my personal experience with this powerful mitochondrial peptide, its scientific mechanisms, clinical applications, dosing guidelines, and the outstanding benefits observed in various human trials. Whether you're looking to enhance your energy levels, improve athletic performance, or support your cardiovascular and cognitive health, SS-31 offers promising solutions. Don't miss out on this essential biohacking tool!
Lockboxes promise price certainty—but the clock can quietly shift value. In this episode, Mike and Ryan break down how a lockbox differs from a classic cash-free/debt-free (CF/DF) deal: fixed price as of a “lockbox date,” no post-close true-up, and a tight definition of permitted vs. non-permitted leakage. They discuss when lockboxes shine (fast closings, cleaner accounting, fewer surprises) and where sellers need to be careful (growth between lockbox date and close often accrues to the buyer). You'll get apples-to-apples comparison tips for evaluating offers, what to watch in tax escrows, and a practical way to translate excess working capital into headline price. If you've ever wrestled with working capital adjustments or wanted a cleaner close, this one's your field guide.Seller checklist:Nail down the lockbox date and permitted leakage list.Quantify excess working capital and reflect it in price.Set a close timeline—faster is safer for sellers.Align on tax items and escrow triggers.Ensure every CF/DF vs. lockbox offer is compared on the same basis. RELATED EPISODES: Episode 154: What will be your take home portion of the deal? Listen now >>Episode 123: Understanding Cash Free Debt Free in M&A Transactions. Listen now >>Episode 100: Looking back at 100 Episodes and Narrowing in on Working Capital. Listen now >>Episode 94: Navigating Undisclosed Liabilities Before, During, and After Close. Listen now >> Listen to Shoot the Moon on Apple Podcasts or Spotify.Buy, sell, or grow your tech-enabled services firm with Revenue Rocket.
M.T. Hyland talks about the research "Mechanisms and modifying factors affecting the impact of adverse childhood experiences on executive function". Read the article in the "Journal of Modern Foreign Psychology" 2025 # 3.
Featuring an interview with Dr Kevin Kalinsky, including the following topics: Patient-Reported Outcomes from the TROPION-Breast01 Study (0:00) Pernas S et al. Datopotamab deruxtecan (Dato-DXd) vs chemotherapy (CT) in previously treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer (BC): Patient-reported outcomes from the TROPION-Breast01 study. ASCO 2024;Abstract 1006. Indirect Comparison of Sacituzumab Govitecan and Datopotamab Deruxtecan for Advanced Breast Cancer (5:04) Pathak N et al. Indirect comparison of sacituzumab govitecan (SG) and datopotamab deruxtecan (Dato-DXd) in advanced breast cancer (aBC): Safety and efficacy analysis. San Antonio Breast Cancer Symposium 2024;Abstract P1-02-02. BEGONIA: A Phase Ib/II Study of Datopotamab Deruxtecan with Durvalumab as First-Line Treatment for Unresectable Advanced Triple-Negative Breast Cancer (9:53) Schmid P et al. Datopotamab deruxtecan (Dato-DXd) + durvalumab (D) as first-line (1L) treatment for unresectable locally advanced/metastatic triple-negative breast cancer (a/mTNBC): Updated results from BEGONIA, a phase Ib/II study. ESMO 2023;Abstract 379MO. Advances in the Use of TROP2-Targeted Antibody-Drug Conjugates for Breast Cancer: Mechanisms, Clinical Applications and Future Directions (15:35) Tong Y et al. Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: Mechanisms, clinical applications, and future directions. Front Immunol 2024;15:1495675. Abstract CME information and select publications
Welcome to the 30th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Professor Gabor G Kovacs of the Brain article entitled: Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy Listen to the fascinating insights exploring the autoimmune side of progressive supranuclear palsy (PSP) following identification of cytotoxic T cells within the mid-brain of PSP post-mortem tissue. The pattern of T cells appears to follow both temporal progression of underlying PSP and may also relate to rate of disease progression. Professor Kovacs discusses potential autoimmune treatment in a neurodegenerative disorder, such as PSP, and others. Check out the full article on the Brain website as part of the August 2025 issue: https://doi.org/10.1093/brain/awaf135 This episode was co-hosted, edited and produced by David Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.
Send us a textIn this episode of PT Snacks podcast, we dive deep into scaphoid fractures, a common yet often mismanaged injury in younger and active individuals. Listeners will learn about the anatomy of the scaphoid bone, the typical mechanisms of injury, common diagnostic challenges, and both conservative and surgical treatment options. We explain the importance of recognizing and adequately managing these fractures to prevent complications like avascular necrosis and non-union. Tune in to enhance your knowledge and clinical skills regarding this significant topic in physical therapy.00:00 Introduction and Welcome00:44 Topic Overview: Scaphoid Fractures01:21 Anatomy of the Scaphoid03:29 Mechanisms and Risk Factors04:27 Diagnosis and Imaging05:11 Differential Diagnosis05:59 Symptoms and Clinical Examination06:36 Treatment Options07:40 Conclusion and Additional ResourcesReferencesSteinmann S, et al. Scaphoid fractures and nonunions: diagnosis and treatment. J Orthop Sci. 2006.Rhemrev S, et al. Current methods of diagnosis and treatment of scaphoid fractures. Int J Emerg Med. 2011.Clementson M, et al. Acute scaphoid fractures: guidelines for diagnosis and treatment. EFORT Open Rev. 2020.Krasin E, et al. Review of the current methods in the diagnosis and treatment of scaphoid fractures. Postgrad Med J. 2001.Krimmer H, et al. [Scaphoid fractures—diagnosis, classification and therapy]. Unfallchirurg. 2000.Clementson M, et al. [Scaphoid fractures – Guidelines for diagnosis and treatment]. Lakartidningen. 2019.Pickrell BB, et al. Update on management of scaphoid fractures. Plast Reconstr Surg. 2024.Go to PT Final Exam using this link to access great studying options to conquer the NPTE!Support the showStay Connected! Make sure to hit follow now so you don't miss an episode! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. You can also join the email list HERE Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less! Prepping for the NPTE? Get all the study tools you need to master it at PT Final Exam. Use code PTSnacks at checkout to get a discount! Want to Support the Show?Help me keep creating free content by: Sharing the podcast with someone who'd benefit. Contributing directly via the link...
Most doctors dream about leaving the ER grind, but here's what's remarkable: Dr. Nico Grundmann didn't just escape - he built something that's actually changing how we think about mental healthcare at scale.In this conversation, Sam sits down with Dr. Grundmann, an emergency physician who took his systems-thinking background and created something unprecedented: a five-location ketamine practice that's generating the kind of data insurance companies actually pay attention to. We're talking about going from solo practitioner to managing 30 team members while maintaining the clinical rigor that makes this work sustainable.What makes this conversation essential listening? Dr. Grundmann's approach shows exactly how individual practices can drive policy-level change - but it requires thinking beyond your patient panel to the broader healthcare system. His story proves that with the right framework, you can build something that's both profitable and positioned to influence national coverage decisions.If you've ever wondered how to scale beyond a single clinic without losing clinical quality, or if you're curious about what it really takes to collect data that insurance companies respect, this conversation will give you the roadmap you need.What You'll Learn in This Episode
Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you've heard ATX-304 described as “exercise in a capsule,” you'll see why after going through the research, mechanisms, human trials, and potential applications.I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.
It's time to talk about my disseration. This short teaser introduces the 4-part series that explains my Master's dissertation from the London School of Economics. The dissertation was titled, “Going for Gold: A Proposal to Raise the Evidentiary Standard of Mechanisms in Rare Disease Medicine.” The four part series will be released as detailed below:Part 1: Introducing the Project & Offering a Brief Overview of Evidence in MedicinePart 2: Establishing a Need for Recalibration of the Evidence StandardPart 3: Arguing for Mechanisms Driving Epistemological ProgressPart 4: Providing the Implementation Plan & Concluding Remarks
Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/0:00 - Intro: why I'm covering Testagen0:30 - The low-T epidemic and TRT context1:12 - Why I'm excited about Testagen vs HCG2:00 - What I'll cover today (what it does, dosing, use cases)2:40 - What Testagen is (KEDG bioregulator peptide)3:12 - Mechanisms and “does this help women?” note4:00 - Core effects: endocrine support + epigenetic action5:00 - Target tissues: pituitary, thyroid, testes, bone marrow6:00 - Vascular/erectile benefits; “calibrating” the HPT axis6:30 - Fertility use case + my personal plan7:16 - Manufacturer indications; sexual function improvements8:12 - Case study: semen parameters quadrupled on Testolutin8:58 - Thyroid support, TBI/central hypo considerations9:58 - Anti-aging & immune modulation overview10:20 - Human evidence: oral Testolutin study (TT, LH/FSH ↑)11:02 - Human evidence: IM Testagen (2.5 mg x 10 days) results11:48 - 2022 combo study (4-peptide stack; free T ↑ ~54%)13:08 - Animal data: pituitary-independent thyroid restoration14:08 - Cell data: nuclear entry, histone/DNA binding14:34 - Outcomes summary: testosterone, LH/FSH, libido15:02 - Testagen vs TRT; stacking with Epitalon/Epithalamin16:01 - Safety profile: “no significant side effects” noted16:56 - Dosing protocol I recommend (2 mg/day, 10–60 days)17:24 - Full male-health stack ideas (Testagen + others)17:40 - Big-picture takeaway: who benefits most18:10 - Real-world reports, call for comments, and thanksI break down Testagen (a KEDG bioregulator) as a legit pathway to support testicular function, HPT axis “calibration,” and fertility—without typical TRT downsides. I walk through how it works at the epigenetic level (nuclear entry, histone/DNA interaction), human and animal evidence (oral Testolutin and injectable Testagen), thyroid and immune benefits, erectile/vascular support, and what I've seen in early adult men with low T. I also share my fertility plan, practical dosing (2 mg/day; 10–60 days), and how I'd pair Testagen with peptides like Epitalon, Libidon, Glandokort, and Superfort for broader rejuvenation. If you've used Testagen, drop your experience—wins or misses—so we can help the community learn what's working.
In Episode 266 we discuss mechanisms and board games that were inspired by the theme they represent.Dave Beck (designer of Distilled and Luthier) also joins us for the discussion and gives us a sneak peak at the upcoming Distilled expansion, Distilled: Cocktails.Timestamps:00:00 Introduction01:06 Distilled: Cocktails15:14 Theme Driven Mechanisms17:25 Obsession19:39 Woodcraft21:35 Captain Sonar28:25 Hegemony: Lead Your Class To Victory36:14 Wingspan, The Fox Experiment37:33 Viticulture, Scoville40:23 Western Legends45:08 Baseball Highlights 2045, Barrage49:35 Nemesis, Batman: Gotham City Chronicles51:33 Android: Netrunner54:43 Flamme Rouge, Heat: Pedal to the MetalIf you enjoy the show, please consider supporting us at https://www.patreon.com/boardgamehottakesFollow us on BlueSky: https://bsky.app/profile/boardgamehottakes.bsky.socialJoin our Board Game Arena Community: https://boardgamearena.com/group?id=11417205Join our Discord server at: https://discord.gg/vMtAYQWURd
Global Ed Leaders | International School Leadership Insights
Ever left a fantastic professional development session feeling completely energised, only to find yourself back to square one a month later? Shane tackles this all-too-familiar scenario in this solo episode, coining it "One Hit Wonder PD" or "Drive-By PD." Shane explores why even the most brilliant, engaging PD days often fail to create lasting change in schools. The problem isn't the quality of the training; it's what happens (or doesn't happen) after the applause dies down and real school life kicks back in. Drawing on research from the Education Endowment Foundation, Shane reveals an uncomfortable truth: most of the responsibility for making professional development stick lies with school leaders themselves. He challenges listeners to focus on just one area this year and provides practical strategies for ensuring PD actually transforms practice rather than just creating good memories. The episode offers a straightforward framework for leaders who want to make their professional development investment count: do the groundwork before training begins, plan the follow-up before the session even happens, and resist the temptation to juggle multiple initiatives. Sometimes going deep on one focus area creates far more impact than spreading efforts across numerous projects.Links MentionedEducation Endowment Foundation - 14 Mechanisms for Effective Professional DevelopmentEEF Professional Development Guidance Episode PartnersTeacher Development TrustInternational Curriculum AssociationJoin Shane's Intensive Leadership Programme at educationleaders.co/intensiveShane Leaning, an organisational coach based in Shanghai, supports school leaders globally. Passionate about empowment, he is the author of the best-selling 'Change Starts Here.' Shane is a leading educational voice in the UK, Asia and around the world.You can find Shane on LinkedIn and Bluesky. or shaneleaning.com Hosted on Acast. See acast.com/privacy for more information.
Sen and Erica welcome Sarah Shipp as the host of the Thinking About Mechanisms segment. This episode, Sarah talks about social distance as one of the main differentiators between video games and tabletop games.
Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity. What You'll Learn: Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health. Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research. Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss. Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions. Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane. Key Takeaways: SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management. Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies. The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity. Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions. Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one’s own biology in response to health interventions. Resources: Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience. Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being. 00:12 Understanding SGLT2 Inhibitors 02:51 Mendelian Randomization and SGLT2 Inhibitors 06:24 Benefits and Mechanisms of SGLT2 Inhibitors 09:47 Discussion on Metformin 14:36 Intermittent Fasting and Ketone Supplements 17:46 Fasting, Autophagy, and Muscle Health 22:38 Exploring Glycine and N-Acetyl Cysteine 24:48 Microplastics: A Growing Concern 26:25 The Impact of Microplastics on Health 31:54 Self-Experimentation with Sulforaphane 38:33 Final Thoughts and Future Work See omnystudio.com/listener for privacy information.
Send us a textThis week we're tackling a food we all know and love: flour. But is it really as harmless as it seems? Join me as I break down the surprising science of refined flour, cravings, and hormones—plus how a few small shifts can help you take back control of your weight loss journey.We'll talk about why flour is classified as an ultra-processed food, how it hijacks hunger signals, and why it can make weight loss feel harder than it should. Don't worry, I'll make it simple, light, and easy to understand—because this is about living your best life, not stressing over bread.Quote of the Week:“Your body is your home—feed it with care.” – Unknown Citations:Monteiro et al., 2019 – Ultra-processed foods: What they are and how to identify them. Public Health Nutrition.Hall et al., 2019 – Ultra-processed diets cause excess calorie intake and weight gain. Cell Metabolism.Ludwig, 2002 – The glycemic index: Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA.Friedman, 2014 – Leptin and the regulation of body weight. American Journal of Clinical Nutrition.Volkow et al., 2013 – The addictive dimensionality of obesity. Biological Psychiatry.Slavin, 2013 – Fiber and prebiotics: Mechanisms and health benefits. Nutrients.Hu, 2011 – Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care.ADA, 2020 – Standards of medical care in diabetes—2020. Diabetes Care.Let's go, let's get it done. Get more information at: http://projectweightloss.org
Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one's for you.Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.comSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Hettas: Use code FEISTY20 for 20% off at https://hettas.com/ Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% off This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy
THE Leadership Japan Series by Dale Carnegie Training Tokyo, Japan
Why vision, mission, and values still matter in 2025—if leaders make them real Not long ago, talking about “vision” often invited sneers. Leaders who spoke about visions were mocked as spouting psychobabble. Part of the cynicism came from the poor quality of early vision statements—trite platitudes that could double as sleeping aids. But times have changed. In 2025, vision, mission, and values are essential leadership tools, yet most organisations still struggle to make them resonate with staff. Why were visions mocked in the past? In the 1980s and 1990s, many vision statements were badly written—either too vague, too long, or too clichéd. Employees saw them as irrelevant. Cynical cultures, like Australia's, dismissed them as hollow leadership exercises. Fast-forward to today, and vision has become mainstream. Companies in Japan, the US, and Europe frame it as a strategic anchor. But credibility remains the challenge: if employees can't recall the vision, they can't live it. Mini-Summary: Early visions failed because they were clichéd or irrelevant. Today they are vital, but only if staff remember and act on them. Do employees actually know their company's vision, mission, and values? Research and field experience suggest most don't. Trainers often test this by flipping framed statements on the wall and asking staff to recite them. Typically, no one remembers the vision or mission, and at best, a few values. In Japan, where employees pride themselves on discipline and detail, this gap is striking. It shows that leadership communication is failing. Employees can't live what they can't recall. Mini-Summary: Most employees cannot recite their organisation's vision, mission, or values—evidence that communication and ownership are missing. Why do so many statements fail to inspire? There are two extremes: bloated statements too long to recall, or cut-down slogans so short they become vapid clichés. Both kill engagement. Worse, leaders often draft them alone, without wordsmithing skills or input from employees. Even when teams co-create content, turnover means newcomers feel no ownership. In Japan, where lifetime employment has eroded, this turnover effect is magnified. Leaders must find mechanisms to refresh ownership constantly. Mini-Summary: Vision and value statements fail when they're too long, too short, or disconnected from employees—especially in high-turnover environments. What practices help embed vision into daily work? One proven method is daily repetition. Ritz-Carlton Hotels review their values at every shift worldwide, with even junior staff leading the discussion. Inspired by this, Dale Carnegie Tokyo holds a “Daily Dale” every morning, where team members take turns to lead the session and recites the vision, mission, and values and discuss one of 60 Dale Carnegie Human Relations Principles. This practice ensures even new hires quickly internalise the culture. Egalitarian leadership—having secretaries, not just presidents, lead—also deepens ownership. Mini-Summary: Embedding vision requires daily rituals, repetition, and egalitarian involvement, not just posters on walls. Should companies also create a “strategic vision”? Yes. Many visions describe identity—who we are and what we stand for—but not direction. During the pandemic, Dale Carnegie Tokyo added a “Strategic Vision” to articulate where the company was heading. In 2025, with Japan navigating digital transformation, demographic decline, and global competition, leaders need both: a cultural compass (vision, mission, values) and a directional map (strategic vision). Without both, organisations drift. Mini-Summary: Companies need two visions: a cultural compass for identity, and a strategic vision for direction—especially in turbulent times. How can leaders bring visions to life in 2025? Leaders must test whether employees know the vision, mission, and values. If they don't, leaders should redesign communication and embedding processes. Mechanisms like daily recitation, story-sharing, and recognition linked to values make culture tangible. The post-pandemic world has raised expectations: employees want meaningful work, and customers want values-driven partners. Leaders who treat vision statements as wallpaper risk being left behind. Mini-Summary: Leaders bring visions to life by testing recall, embedding practices into daily routines, and aligning recognition with values. Conclusion Vision, mission, and values were once dismissed as leadership fluff. Today, they are essential but often forgotten or poorly implemented. In 2025, leaders in Japan and globally must transform them into living tools—clear, repeatable, and tied to both culture and strategy. If your team can't recite your vision, mission, and values today, you don't have a culture—you have a poster. About the Author Dr. Greg Story, Ph.D. in Japanese Decision-Making, is President of Dale Carnegie Tokyo Training and Adjunct Professor at Griffith University. He is a two-time winner of the Dale Carnegie “One Carnegie Award” (2018, 2021) and recipient of the Griffith University Business School Outstanding Alumnus Award (2012). As a Dale Carnegie Master Trainer, Greg is certified to deliver globally across all leadership, communication, sales, and presentation programs, including Leadership Training for Results. He has written several books, including three best-sellers — Japan Business Mastery, Japan Sales Mastery, and Japan Presentations Mastery — along with Japan Leadership Mastery and How to Stop Wasting Money on Training. His works have also been translated into Japanese, including Za Eigyō (ザ営業), Purezen no Tatsujin (プレゼンの達人), Torēningu de Okane o Muda ni Suru no wa Yamemashō (トレーニングでお金を無駄にするのはやめましょう), and Gendaiban “Hito o Ugokasu” Rīdā (現代版「人を動かす」リーダー). In addition to his books, Greg publishes daily blogs on LinkedIn, Facebook, and Twitter, offering practical insights on leadership, communication, and Japanese business culture. He is also the host of six weekly podcasts, including The Leadership Japan Series, The Sales Japan Series, The Presentations Japan Series, Japan Business Mastery, and Japan's Top Business Interviews. On YouTube, he produces three weekly shows — The Cutting Edge Japan Business Show, Japan Business Mastery, and Japan's Top Business Interviews — which have become leading resources for executives seeking strategies for success in Japan.
In this conversation, Dr. Jason Sonners, a chiropractor and expert in hyperbaric medicine, shares his journey into the field of hyperbaric oxygen therapy (HBOT). He discusses the science behind HBOT, its mechanisms of action, and its applications in various health conditions, including cancer, brain health, and long COVID. Dr. Saunders emphasizes the importance of safety in hyperbaric therapy and the differences between soft and hard chambers. He also highlights the future of hyperbaric medicine and the growing awareness of its benefits.Chapters00:00 Introduction to Hyperbaric Medicine and Dr. Jason Sonners02:47 The Personal Journey to Hyperbaric Therapy05:50 Understanding Hyperbaric Oxygen Therapy (HBOT)09:09 Mechanisms of Healing: How HBOT Works11:48 The Role of HBOT in Cancer Treatment14:59 Comparing Soft and Hard Hyperbaric Chambers17:52 The Future of Hyperbaric Research and Applications27:00 The Science of Hyperbaric Therapy28:02 Creating Effective Protocols29:39 Combining Therapies for Optimal Results32:02 Understanding Telomeres and Aging33:10 Choosing the Right Hyperbaric Chamber39:11 Hyperbaric Therapy for Long COVID41:58 Addressing Brain Injuries and Cognitive Function45:28 The Future of Hyperbaric Medicine
In this episode, Erin and Autumn welcome Tim, a registered nurse, to discuss the dark side of nursing through the cases of Niels Högel and Charles Cullen, both male nurses who committed heinous crimes. The conversation explores the motivations behind their actions, the failures of hospital systems to protect patients, and the emotional toll on healthcare professionals. The hosts emphasize the importance of trust in healthcare and reflect on the need to appreciate the good nurses who work tirelessly to care for patients.Chapters00:00 Introduction and Guest Introduction02:36 Tim's Nursing Background and Role03:21 Exploring Cases of Male Nurses07:12 The Case of Niels Högel07:34 Understanding the Role of Nurses in Patient Care12:16 The Mechanisms of Medical Murder17:09 The Investigation and Arrest of Högel20:07 The Trial and Conviction of Niels Högel21:32 The Aftermath and Implications for Healthcare27:39 The Role of Nurses in Healthcare28:10 Introduction to Charles Cullen29:11 The Early Life of Charles Cullen31:09 The Start of a Nightmare32:58 The Pattern of Death35:29 The Arrest of Charles Cullen37:27 The Aftermath of Cullen's Crimes39:28 The Impact on Healthcare Practices42:11 The Importance of Trust in Nursing45:32 Conclusion and Reflection48:18 outro.wavKeywordsnursing, true crime, male nurses, medical murder, Niels Högel, Charles Cullen, healthcare, hospital safety, criminal cases, podcast
Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential biological mechanisms that could connect psychedelics to the aging process.0:00 - Why I'm Talking About Psilocybin3:08 - The Science of Psilocybin & Serotonin6:36 - Breaking Down The New Paper10:09 - The "Psilocybin Telomere Hypothesis"12:02 - The Cell Study: A Critical Look17:51 - The Lifespan Study in Mice (The Main Event)23:56 - How Could It Work? (Exploring the Mechanisms)30:55 - Final Thoughts & Future QuestionsProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
LEAVE A REVIEW if you liked this episode!!Let's Connect On Social Media!youtube.com/anthonyvicinotwitter.com/anthonyvicinoinstagram.com/theanthonyvicinohttps://anthonyvicino.comJoin an exclusive community of peak performers at Beyond the Apex University learning how to build a business, invest in real estate, and develop hyperfocus.www.beyondtheapex.com
Danielle Sulikowski, professor of evolutionary psychology, presents a controversial theory on why global fertility rates and birth rates are collapsing. She argues that an evolutionary strategy known as female mate suppression—where dominant women repress the reproductive success of rivals—has shifted in humans into a modern form of antinatal social contagion. Rather than direct biological suppression, the strategy manifests as propaganda and cultural messaging that discourage motherhood, promote career over family, and accelerate population decline. We explore how intrasexual competition among women could shape civilization itself, why some groups might defect against their own society to gain an evolutionary edge, and how this connects to broader debates in feminism, cultural evolution, and civilizational collapse. The conversation also ties in the density-dependent dynamics of Calhoun's Rat Utopia experiments as a possible parallel to modern urbanization, social media, and declining birth rates.PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showOUR HOMEBREWED MUSICCheck out our band's new album:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-hereVinyl pre-orders available now: https://buy.stripe.com/14A5kC3Od5d21Ms7zPdEs0900:00 Go! Introducing the Central Crisis of Western Civilization00:05:53 Intrasexual mate Suppression in Animals00:09:03 The Mechanisms of Intrasexual Competition00:12:29 Competitive Mothering Dynamics00:18:03 Advising on Haircut Strategies00:20:07 Understanding Intrasexual Competition Measurement00:21:56 Female Competitiveness Dynamics00:25:10 Personal Experiences with Gender Dynamics00:29:32 Navigating Social Circles and Competition00:33:00 Changes in Intersexual Competitiveness Among Women00:38:05 Feminism and Reproductive Suppression00:42:27 Societal Trends and Competitive Behavior00:43:10 Human Behavior and Civilization Cycles00:46:08 Decline of Birth Rates and Societal Institutions00:50:20 Reproductive Strategies and Societal Feedback Loops00:53:07 The Role of Intellectual Discourse in Civilizational Shifts00:56:15 Rationalizing Birth Rate Declines01:00:21 Evolutionary Explanations for Civilizational Behavior01:05:25 Empirical Examination of Birth Rate Decline01:09:12 Exploring Male Responses and Societal Dynamics01:12:15 Intersecting Ideologies and Population Messaging01:20:00 Internet Influence on Cultural Dynamics01:25:00 Mechanistic and Functional Explanations of Behavior01:27:03 Discussion on Societal Decline and Birth Rates01:31:21 Exploring Societal Change and Its Cyclical Nature01:35:34 The Role of Technology and Interconnectedness01:40:13 Urbanization Effects and Cultural Dynamics01:44:27 Gender Dynamics and Cultural Evolution01:47:44 Discussion on Social Influence and Elite Classes01:51:50 Class and Reproductive Strategies01:54:43 Urbanization's Impact on Society02:00:08 Evolution vs. Morality in Society02:02:57 Urban Density and Human Behavior02:07:45 Bioconservatism vs. Transhumanism02:09:00 Transhumanism and the Unknown Future02:12:53 Understanding Unseen Forces02:15:11 The Quest for Understanding#evolutionarypsychology , #civilization, #feminism, #sociology, #anthropology, #culturewars, #birthrates, #psychology, #society, #population, #decline, #history, #civilizations, #future #philosophypodcast , #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities.
Today Lee Sharkey of Goodfire joins The Cognitive Revolution to discuss his research on parameter decomposition methods that break down neural networks into interpretable computational components, exploring how his team's "stochastic parameter decomposition" approach addresses the limitations of sparse autoencoders and offers new pathways for understanding, monitoring, and potentially steering AI systems at the mechanistic level. Check out our sponsors: Oracle Cloud Infrastructure, Shopify. Shownotes below brought to you by Notion AI Meeting Notes - try one month for free at https://notion.com/lp/nathan Parameter vs. Activation Decomposition: Traditional interpretability methods like Sparse Autoencoders (SAEs) focus on analyzing activations, while parameter decomposition focuses on understanding the parameters themselves - the actual "algorithm" of the neural network. No "True" Decomposition: None of the decompositions (whether sparse dictionary learning or parameter decomposition) are objectively "right" because they're all attempting to discretize a fundamentally continuous object, inevitably introducing approximations. Tradeoff in Interpretability: There's a balance between reconstruction loss and causal importance - as you decompose networks more, reconstruction loss may worsen, but interpretability might improve up to a certain point. Potential Unlearning Applications: Parameter decomposition may make unlearning more straightforward than with SAEs because researchers are already working in parameter space and can directly modify vectors that perform specific functions. Function Detection vs. Input Direction: A function like "deception" might manifest in many different input directions that SAEs struggle to identify as a single concept, while parameter decomposition might better isolate such functionality. Knowledge Extraction Goal: A key aim is to extract knowledge from models by understanding how they "think," especially for tasks where models demonstrate superhuman capabilities. Sponsors: Oracle Cloud Infrastructure: Oracle Cloud Infrastructure (OCI) is the next-generation cloud that delivers better performance, faster speeds, and significantly lower costs, including up to 50% less for compute, 70% for storage, and 80% for networking. Run any workload, from infrastructure to AI, in a high-availability environment and try OCI for free with zero commitment at https://oracle.com/cognitive Shopify: Shopify powers millions of businesses worldwide, handling 10% of U.S. e-commerce. With hundreds of templates, AI tools for product descriptions, and seamless marketing campaign creation, it's like having a design studio and marketing team in one. Start your $1/month trial today at https://shopify.com/cognitive
Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Send us a textIn this episode of PT Snacks Podcast, we discuss the essentials of Platelet Rich Plasma (PRP) for physical therapists and students. Learn about the creation and types of PRP, its intended effects, and practical applications in treating various conditions such as osteoarthritis, ligament injuries, and tendinopathies. We also dive into the evidence supporting PRP's effectiveness and provides insights on how to communicate this information to patients. 00:00 Introduction to PT Snacks Podcast00:45 Today's Topic: Platelet Rich Plasma (PRP)01:39 Understanding PRP: What It Is and How It's Made02:50 Types of PRP: Leukocyte Rich vs. Leukocyte Poor03:31 Mechanisms of PRP: How It Works05:37 Effectiveness of PRP: When Does It Work?07:25 Further Learning and Resources08:35 Conclusion and Contact InformationMiddleton K et al. (2012). The Iowa Orthopaedic Journal – PRP in soft tissue injuries.Zhang N et al. (2013). The Scientific World Journal – Bone healing mechanisms.Park HB et al. (2011). Korean Journal of Hematology – Cytokine profiles and MMPs.Woodall JW et al. (2008). Biomedical Sciences Instrumentation – Inflammatory modulation.Zhou Y et al. (2017). Journal of Tissue Engineering – Tendon-bone interface and PRP.Chalidis B et al. (2023). Int. J. Mol. Sci. – PRP in tendon/ligament regeneration.Kobayashi Y et al. (2020). Journal of Experimental Orthopaedics – Angiogenesis and collagen in tendon healing.Hada S et al. (2024). Cureus – PRP in ACL injuries.Kalbkhani M et al. (2014). Applied Soft Computing – PRP in experimental OA.Gobbi A et al. (2014). PRP in Early OA of the Knee.Support the showWhy PT Snacks Podcast?This podcast is your go-to for bite-sized, practical info designed for busy, overwhelmed Physical Therapists and students who want to build confidence in their foundational knowledge without sacrificing life's other priorities. Stay Connected! Never miss an episode—hit follow now! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. Join the email list HERE On Instagram? Find unique content at @dr.kasey.hankins! Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less!(These are affiliate links, but I only recommend Medbridge because it's genuinely valuable.) Optimize Your Patient Care with Tindeq: Get 10% off with code PTSNACKS10: [Tindeq] ...
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Michael Lynch, Ph.D., Director of the Center for Mechanisms of Evolution at Arizona State University and Vaughn Cooper, Ph.D., professor of Microbiology and Molecular Genetics at the University of Pittsburgh, School of Medicine, examine the origins and trajectory of early microbial life (EML) and discuss the collaborative report between the American Academy of Microbiology and the Gordon and Betty Moore Foundation, which explores the journey of life on Earth, from non-living chemical compounds to early unicellular life, to the vast diversity of organisms we see today. This episode is brought to you by the American Academy of Microbiology, a think tank at American Society for Microbiology and the Gordon and Betty Moore Foundation, which has been dedicated to advancing scientific discovery for the past 25 years. Links for This Episode: Project Report Early Microbial Life: Our Past, Present and Future. Article: The Great Oxidation Event: How Cyanobacteria Changed Life. MTM Podcast: From Hydrothermal Vents to Cold Seeps: How Bacteria Sustain Ocean Life With Nicole Dubilier. Take the MTM listener survey!
Today, Asif and Ali discuss the news making comedy series ‘South Park' (1:35). They discuss the show's creation, early development and success (and why Ali didn't like it initially). They discuss famous episodes as well as other successes from Trey Parker and Matt Stone including the South Park Movie, Team America: World Police and The Book of Mormon. Finally, they discuss the recent $1.5 billion deal they reached with Paramount, as well as the show satirizing and skewering President Donald Trump. Then the guys discuss pickleball injuries (30:32)…after Ali explains the game and they both make fun of it for a bit. Asif then explains how pickleball injuries have been on the rise with the exponential popularity of the game. Asif talks about how common these injuries are, who is at risk and what part of the body is most commonly injured. Finally, Asif discusses how to prevent pickleball injuries. The opinions expressed are those of the hosts, and do not reflect those of any other organizations. This podcast and website represents the opinions of the hosts. The content here should not be taken as medical advice. The content here is for entertainment and informational purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. Music courtesy of Wataboi and 8er41 from PixabayContact us at doctorvcomedian@gmail.com‘South Park' creators reach $1.5-billion streaming deal with Paramount” https://www.latimes.com/entertainment-arts/business/story/2025-07-21/south-park-creators-reach-breakthrough-in-paramount-deal-talks‘South Park' premiere skewers Trump and Paramount in fiery return”: https://www.cnn.com/2025/07/24/entertainment/south-park-premiere-trump-paramountIncreasing Incidence of Pickleball Injuries Presenting to US Emergency Departments: A 10-year Epidemiologic Analysis of Mechanisms and Trends: https://pmc.ncbi.nlm.nih.gov/articles/PMC11758564/Pickleball injuries are on this rise. Here are 10 tips to avoid them while playing: https://health.ucdavis.edu/news/headlines/pickleball-injuries-are-on-this-rise-here-are-tips-to-avoid-them-while-playing/2024/08 Hosted on Acast. See acast.com/privacy for more information.
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In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy. References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15 Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Dynamic Aging Retreat Oct 3-5 2025This Episode's Show NotesJoin Our Newsletter: Movement Colored GlassesIn this episode, Katy Bowman and Jeannette Loram dive into the fascinating relationship between blood sugar, diet, and movement. They unpack how the body regulates blood sugar, what happens when this process breaks down in Type I and Type II diabetes, and why different kinds of activity play such a big role in prevention and management.Katy and Jeannette explain how contracting muscles can pull glucose directly into working cells during exercise—a powerful but site-specific effect—and how long-term training reshapes muscle to take up glucose more efficiently.They also compare the blood sugar benefits of endurance exercise, resistance training, HIIT, stretching, and even light daily movement. Along the way, they highlight two key scenarios: insulin resistance linked to excess weight and inflammation, versus insulin resistance driven by low muscle mass in people with normal weight. For the latter, they stress why resistance training—or “big body work”—is especially essential.CHAPTERS 0:06:00 - Definitions 0:16:00 - The Dynamic Collective 0:17:00 - You Can't Exercise Off Diabetes 0:20:00 - Muscle is the Key Tissue (and the Liver)0:36:30 - Stretching & Light Activity 0:47:00 - Exercise Modality for Blood Sugar Regulation0:54:25 - Listener Question on Lupus brought to you by Peluva 1:09:09 - Blood Sugar Spikes During Exercise BOOKS & RESEARCH PAPERS My Perfect Movement Plan by Katy BowmanI know I should Exercise, But... by Diana Hill & Katy BowmanExercise and GLUT4 by Flores-Opazo et al (2020) Mechanisms of endurance and resistance exercise in type 2 diabetes by Zhao et al (2025) Sedentary behaviour as a mediator of type 2 diabetes by Hamilton et al (2015) Impact of reduced sitting time or increasing sit-to-stand transitions on blood pressure and glucose regulation in Postmenopausal women by Hartman et al (2025) The impact of standing desks on cardiometabolic and vascular health by Bodker et al (2021) MADE POSSIBLE BY OUR WONDERFUL SPONSORS:Sweet Skins, organic hemp and cotton clothing that is stylish, flexible and designed to move with you, take 20% off with code Movement20Peluva, Five-toe minimalist sports shoes ideal for walking and higher impact activities. Take 15% off with code NUTRITIOUSMOVEMENTIkaria Design, creators of the Soul Seat®, a height adjustable chair that allows you to sit in diverse shapes including cross-legged, take 10% of new inventory with code DNA10Venn Design, beautiful floor cushions and ball seats that keep you moving at home or at the officeEarth Runners, minimalist sandals that mimic being truly barefoot through their grounding technology, take 10% off with code DNA10Smart Playrooms, design and products to keep you and your kids engaged and active at home, take 10% off monkey bars, rock wall panels and holds with code DNA10
در اسلایدکست دوم،به کامپوزیتهایی میپردازیم که به علت خاصیت chameleon effect همرنگ دندان اطراف دیده میشندر مورد علت تکنولوژی مزایا معایب این کامپوزیتها صحبت میکنیمدر هقت دقیقه و با اسلاید بیاموزیداسلایدکست روش دیگه ی آموختنه،با اسلاید و هوش مصنوعیبرای استفاده ی تصویری به کانال تلگرام مراجعه کنید⚡️⚡️ دکتر فؤاد شهابیان ⚡️⚡️متخصص پروتزهای دندانی Hosted on Acast. See acast.com/privacy for more information.
Deep dive with Dan Hendrycks, a leading AI safety researcher and co-author of the "Superintelligence Strategy" paper with former Google CEO Eric Schmidt and Scale AI CEO Alexandr Wang.*** SPONSOR MESSAGESGemini CLI is an open-source AI agent that brings the power of Gemini directly into your terminal - https://github.com/google-gemini/gemini-cliProlific: Quality data. From real people. For faster breakthroughs.https://prolific.com/mlst?utm_campaign=98404559-MLST&utm_source=youtube&utm_medium=podcast&utm_content=script-gen***Hendrycks argues that society is making a fundamental mistake in how it views artificial intelligence. We often compare AI to transformative but ultimately manageable technologies like electricity or the internet. He contends a far better and more realistic analogy is nuclear technology. Like nuclear power, AI has the potential for immense good, but it is also a dual-use technology that carries the risk of unprecedented catastrophe.The Problem with an AI "Manhattan Project":A popular idea is for the U.S. to launch a "Manhattan Project" for AI—a secret, all-out government race to build a superintelligence before rivals like China. Hendrycks argues this strategy is deeply flawed and dangerous for several reasons:- It wouldn't be secret. You cannot hide a massive, heat-generating data center from satellite surveillance.- It would be destabilizing. A public race would alarm rivals, causing them to start their own desperate, corner-cutting projects, dramatically increasing global risk.- It's vulnerable to sabotage. An AI project can be crippled in many ways, from cyberattacks that poison its training data to physical attacks on its power plants. This is what the paper refers to as a "maiming attack."This vulnerability leads to the paper's central concept: Mutual Assured AI Malfunction (MAIM). This is the AI-era version of the nuclear-era's Mutual Assured Destruction (MAD). In this dynamic, any nation that makes an aggressive, destabilizing bid for a world-dominating AI must expect its rivals to sabotage the project to ensure their own survival. This deterrence, Hendrycks argues, is already the default reality we live in.A Better Strategy: The Three PillarsInstead of a reckless race, the paper proposes a more stable, three-part strategy modeled on Cold War principles:- Deterrence: Acknowledge the reality of MAIM. The goal should not be to "win" the race to superintelligence, but to deter anyone from starting such a race in the first place through the credible threat of sabotage.- Nonproliferation: Just as we work to keep fissile materials for nuclear bombs out of the hands of terrorists and rogue states, we must control the key inputs for catastrophic AI. The most critical input is advanced AI chips (GPUs). Hendrycks makes the powerful claim that building cutting-edge GPUs is now more difficult than enriching uranium, making this strategy viable.- Competitiveness: The race between nations like the U.S. and China should not be about who builds superintelligence first. Instead, it should be about who can best use existing AI to build a stronger economy, a more effective military, and more resilient supply chains (for example, by manufacturing more chips domestically).Dan says the stakes are high if we fail to manage this transition:- Erosion of Control- Intelligence Recursion- Worthless LaborHendrycks maintains that while the risks are existential, the future is not set. TOC:1 Measuring the Beast [00:00:00]2 Defining the Beast [00:11:34]3 The Core Strategy [00:38:20]4 Ideological Battlegrounds [00:53:12]5 Mechanisms of Control [01:34:45]TRANSCRIPT:https://app.rescript.info/public/share/cOKcz4pWRPjh7BTIgybd7PUr_vChUaY6VQW64No8XMs
On this episode, Ben Azadi sits down with quantum wellness expert Todd Shipman for a fascinating deep dive into the unseen forces affecting your health—electromagnetic fields (EMFs) and quantum energy. Todd shares his personal journey and reveals how Leela Quantum's cutting-edge tools, like the Infinity Block and Quantum Upgrade, are designed to shield the body from EMF stress, supercharge your mitochondria, and boost heart rate variability. Think of it as creating a “protective bubble wrap” around your body—helping you feel calmer, more energized, and better equipped to thrive in today's tech-saturated world. Backed by compelling science and real-world stories, this conversation offers practical ways to protect your health, optimize your metabolism, and live with less stress—even when you're surrounded by screens and devices.
In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page. Mind Pump Fit Tip: Ten Ways to Dramatically Improve Workout Consistency. (1:31) One of the EASIEST ways to bump protein and cut calories. (27:47) When you have kids, it's not about you and it's about them. (31:01) Make Orwell fiction again. (37:07) Diet is religion. (39:01) Exercise and depression. (42:01) Green Juice makes you feel good. (52:17) #Quah question #1 – I love your guys' programs. I do see people comment about how Arnold presses are a terrible movement. I do see you guys have them in your programming. How do you feel about the negative comments towards that exercise? (54:54) #Quah question #2 – What is the ideal mindset to have for people starting their health and fitness journey? (58:21) #Quah question #3 – What is something I can do during long rest periods? I want to avoid phones as much as I can, only tracking sets. (1:00:24) #Quah question #4 – I'm becoming a personal trainer, mostly because of you guys, and just landed my first client. What steps should I take from here? (1:06:47) Related Links/Products Mentioned Visit Butcher Box for this month's exclusive Mind Pump offer! ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! ButcherBox members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off** July Special: MAPS Split or Anabolic Metabolism Bundle 50% off! ** Code JULY50 at checkout ** 6 Benefits of Walking After Meals, Backed by Health Experts Mind Pump #1522: How to Stay Consistent With Your Diet & Workout Mind Pump #2612: How One Man Lost Over 300 Pounds Without Any Cardio 7 Health Benefits of Pasture-Raised Chicken You Can't Ignore George Orwell's estate approves retelling ‘1984' from woman's point of view 1984: 75th Anniversary Mind Pump #2644: Eight Best Carbs for Bodybuilding & More (Listener Live Coaching) The Effects and Mechanisms of Exercise on the Treatment of Depression The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study Get your free Sample Pack with any “drink mix” purchase! Find your favorite LMNT flavor, or share it with a friend. Try LMNT risk-free. If you don't like it, give it away to a salty friend and we'll give you your money back, no questions asked! Visit DrinkLMNT.com/MindPump Mind Pump #1447: How to Start Your Fitness Journey Trainer Bonus Series Episode 1: The Successful Trainer Mindset Trainer Bonus Series Episode 2: Diet & Exercise Strategies That Work AND Clients Love Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Jamie Selzler (@jselzler) Instagram Paul Chek (@paul.chek) Instagram
In recent years “Zone 2 training” has gained immense popularity in fitness and health circles, often being proclaimed the “best” cardiovascular training for metabolic health. Zone 2 training is sustained, low-intensity exercise below the lactate threshold that is commonly employed by many elite level endurance athletes, with a variety of proposed performance benefits. This led to interest from health-conscious folks about its ability to improve markers like VO2 max and mitochondrial function, which are associated with better health outcomes and longevity. Prof. Brendon Gurd, an exercise physiologist at Queen's University, is the co-author of a recent review published in Sports Medicine that examined some of the claims made around zone 2 training and health in the general population. This episode looks at whether the evidence truly supports Zone 2 as a uniquely effective training zone or if this hype has outpaced the research. These insights help professionals and individuals make evidence-based recommendations and avoid unintended negative consequences of following certain ideas. About The Guest Dr. Brendon Gurd is a Professor in the School of Kinesiology and Health Studies at Queen's University, where his research focuses on exercise physiology and skeletal muscle adaptation. His work explores how different intensities and types of exercise influence mitochondrial content and function in muscle tissue, with the goal of understanding how to optimize health and performance through training. Timestamps [03:23] Discussion with Professor Brendan Gurd [05:56] Zone two training: Mechanisms and misconceptions [10:56] Practical applications and recommendations [22:16] Research gaps and future directions [35:47] Key ideas segment (Sigma Nutrition Premium) Links to Resources Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course List of Sigma's Recommended Resources Review paper: Storoschuk et al., 2025 – Much Ado About Zone 2: A Narrative Review Assessing the Efficacy of Zone 2 Training for Improving Mitochondrial Capacity and Cardiorespiratory Fitness in the General Population Lecture Slides: Prof. Brendon Gurd – Is Zone 2 the optimal intensity for inducing mitochondrial adaptation?
"Marcello" self-censors in efforts to feel safe. He asks Jessica for help understanding how he can get out of his own way. The two go deep into his coping mechanisms in this week's episode.
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