Podcasts about mechanisms

Send us a textThis week we are talking about our life lines. I ask you to consider — who's your lifeline?Not the metaphorical one, but the real, human connection that keeps you afloat when life gets heavy.We'll dig into the interesting history of the word “lifeline,” what research says about how connection affects our health and habits, and how you can create your own H-Factor system of support.It's practical and deeply human —you'll leave reminded that you were never meant to do this alone. Quote of the week“My humanity is bound up in yours, for we can only be human together. When we see the other as part of ourselves, we begin to build a world where no one is left behind.”by Desmond TutuInstagram: fina.projectweightlossCitationsEtymonline. (2024). Lifeline – Origin & Definition. Retrieved from etymonline.comUchino, B. N. (2020). Social support and health: A review of physiological processes potentially underlying links to disease outcomes. National Center for Biotechnology Information (NCBI).Lakey, B., & Orehek, E. (2022). Perceived social support and mental health: A review of recent findings.Frontiers in Psychology.Maher, C. A. et al. (2020). Social support and weight-loss interventions: Mechanisms of behavior change.Frontiers in Psychology.Let's go, let's get it done. Get more information at: http://projectweightloss.org

Mentor Sessions Ep. 037: Michael Morelli on Rock Bottom Addiction Recovery, Building a Bitcoin-Powered Fitness Empire, Parallels to Sound Money & Radical LongevityMichael Morelli's Bitcoin journey mirrors his brutal addiction recovery: from high more than sober for a decade, snorting oxycodone amid bankruptcy and affairs, to a 113-day shred from 25% to 8% body fat—bootstrapping FitScript into a multimillion-dollar data-driven health empire coaching 600+ men with peak biomarkers while stacking BTC as a maxi since 2020. Inspired by Saifedean Ammous' "The Bitcoin Standard," Morelli draws logical parallels between paleo nutrition's ancestral simplicity and Bitcoin's finite, sound money—why it's the only asset that "just seems logical" in a fiat-fueled health and wealth disparity crisis. In this BTC Sessions interview, he busts carnivore myths (labs "fucking wrecked"), unpacks peptides for faster gains, red light therapy hacks, and his no-excuses mantra: if a coke-addicted bankrupt can rebuild to live until 150, stacking sats with low-time preference, Bitcoiners have zero excuses for subpar health. Topics:Brutal rock bottom: Addiction, abuse & what led there113-day rebirth: Fatherhood spark & no-excuses mindsetBootstrapping empire: Mom's basement to millionsFitness myths busted: Carnivore dangers & paleo logicBitcoin awakening: Shitcoins to maxi via SaifedeanHealth-money parallels: Disparity extremes & white coat trapsActionable optimization: Low-hanging fruit for BTC stackersPeptides decoded: Mechanisms for faster recoveryRed light therapy: Mitochondria boost & hair regrowthEntrepreneurship grit: Fuck Aging brand & mindset masteryChapters:00:00 Teaser & Intro01:24 Background & Journey02:09 Addiction & Rock Bottom04:42 No Excuses06:10 Abuse & Roots13:04 Fitness & Control16:34 Empire Collapse19:03 Biz Success23:42 Myths & Paleo26:13 Lab & FitScript31:05 BTC Parallels & Journey33:06 Disparities & Pharma38:50 Actionable Tips43:07 Longevity & Alpha47:53 Peptides & Red Light1:02:45 Outro & DiscountAbout Michael MorelliPerformance health engineer, founder FitScript. Test, don't guess. X.com: @morellifitFitScript: fitscript.me (mention podcast for $1000 off)Check previous ep with Prince Filip of Serbia: https://youtu.be/h7kyNNUuLOg

Cracked teeth — the diagnosis we all hate as Dentists! How do you decide when to monitor and when to intervene? What is the recommended intervention at different scenarios of cracks? Should we be chasing cracks and reinforcing with fibers; is there actually enough long-term data to support that approach? Over the years, we've had some epic episodes on this topic — from Kreena Patel's “I Hate Cracked Teeth” (PDP028) to Dr. Lane Ochi's Masterclass on Diagnosis and Management (PDP175). But in this brand-new episode, Jaz is joined by Dr. Masoud Hassanzadeh to bring it all together — not just the diagnosis of cracks, but their management. They explore when to intervene, the role of fibers in preventing propagation, and even the fascinating possibility that cracks in teeth may have some ability to heal, just like bone! This one's a deep dive that will change how you talk to patients — and how you approach cracked teeth in your own practice. https://youtu.be/VHYRBnfJS3I Watch PDP246 on YouTube  Protrusive Dental Pearl Your patient's history predicts the future! Ask if past extractions were difficult → clues you into anatomical challenges. Ask how they lost other teeth → if cracks, be proactive with today's cracks. History isn't just background—it's a clinical tool. Key Takeaways Cracks in teeth can be diagnosed using magnification and high-quality imaging. Patient factors such as age and muscle strength play a significant role in crack prognosis. Symptomatic cracks should be treated to prevent further propagation. Understanding the anatomy of the tooth is crucial for effective treatment. The healing mechanism of cracks in teeth is possible but varies between enamel and dentin. Fibers can be used to strengthen restorations and manage cracks effectively. Long-term studies are needed to assess the effectiveness of current crack management protocols. The use of fluorescence filters can help identify bacteria in cracks. Chasing cracks should be done cautiously to avoid pulp exposure. A comprehensive understanding of crack mechanics can improve treatment outcomes. Highlights of this episode: 00:00 Teaser 00:47 Intro 03:08 Protrusive Dental Pearl - The Importance of Dental History 07:18 Interview with Masoud Hassanzadeh 08:22 Diagnosing and Managing Cracks 21:13 When to Intervene on Cracks 25:50 Restoration Techniques and Materials 28:30 Chasing Cracks: Guidelines and Techniques 36:50 Mechanisms of Crack Healing in Teeth 45:11 Exploring the Use of Fibers in Dentistry 52:43 Introducing the Book on Cracked Teeth 54:57 Percussion-Based Diagnostics (QPD) 56:44 Key Takeaways 57:21 Conclusion and Final Thoughts 01:00:07 Outro As promised, here are the studies mentioned during the discussion: Why cracks do not propagate as quickly in root dentin: Study 1a & 1b Root dentin has significantly higher fracture toughness compared to coronal dentin—nearly twice as tough, as demonstrated in multiple studies. The key difference lies in their structure and toughness. Root dentin's unique collagen orientation adds strength, while its fewer lumens and thinner peritubular cuffs make it less brittle. In contrast, coronal dentin has thicker cuffs, which increase brittleness. Unlike coronal dentin, which fractures uniformly, radicular dentin is anisotropic—its fracture behavior varies depending on direction. These structural features give root dentin greater resistance to cracking, making it more durable under stress. Studies on decreasing crack length due to crack repair in enamel. Study 2 The importance of the modulus of elasticity of the final restoration in arresting crack propagation. Study 3 The role of fiber in restoring cracked teeth and how it can increase fracture strength—even surpassing that of natural teeth. Study 4 Decision Making for Retention of Endodontically Treated Posterior Cracked Te...

In this episode of the Flex Diet Podcast, I sit down with my good friend Dr. Dan Pardi for a deep dive into all things health, longevity, and cognitive performance. We get into the science of stem cells and aging, the real benefits (and limits) of popular supplements, and how nootropics like Ritalin and Modafinil actually work—or don't—in the real world.We also talk about how to integrate training and movement into insanely busy lives, the psychology of health behavior, and why being flexible in your approach (not just in your hamstrings) is key to long-term success.This episode is brought to you by Quaia Life, where Dan's doing some fascinating work on cutting-edge supplements designed to optimize health and performance. They're offering listeners 15% off their products, which you can grab through the link in the show notes.If you want a mix of actionable tips, science-backed insights, and a peek behind the curtain of how top researchers think about performance and aging, you'll definitely want to tune in.Sponsors:Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8Qualia: https://qualialife.com/drmike15Coupon Code: DRMIKE15 (listeners get an additional 15% off any Qualia order)Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:01:51 Science Communication and Cognitive Performance02:43 Sponsorship and Product Endorsement04:54 The Importance of Flexibility in Training06:39 Integrative and Opportunistic Training15:50 The Psychology of Health and Performance24:12 Quality of Life and Nootropics31:12 Understanding Cognitive Enhancement44:30 Modafinil and Its Effects50:50 Exploring the Benefits and Downsides of a New Drug51:22 Mechanisms and Effects of the Drug52:42 Hallmarks of Aging and Their Impact58:07 Understanding Stem Cells and Their Functions01:01:52 Formulating a Stem Cell Supplement01:10:18 Sequencing Protocols for Optimal Health01:15:13 Challenges and Research in the Supplement Industry01:23:33 Final Thoughts and Recommendations01:34:29 Podcast Conclusion and Disclaimers Flex Diet Podcasts You May Enjoy: Episode 263: Lifestyle, Longevity, and the Future of GLP-1 Agonist Use in Wellness with Christa RymalYouTube: https://youtu.be/SlALIb74KvMEpisode 165: Health, Sports Performance and Longevity Medicine: Dr Rick Cohen with Dr. Mike T NelsonYouTube: https://youtu.be/bYk_wzBJzJYConnect with Dr Pardi:Qualia: https://www.qualialife.com/Instagram: https://www.instagram.com/dan_pardiGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

"Send me a text"In this episode, discover how to boost your supplement marketing success during Black Friday and Cyber Monday by mastering high-converting mechanisms tailored for fast-moving buyers. Discover how to compress your unique selling mechanism without losing its persuasive impact to drive e-commerce growth and stand out from competitors.Learn the two-part mechanism framework (trust + hope)How to ground your messaging in logic instead of hypeWhich ingredients to spotlightThe three-sentence mechanism formula that converts deal-hunters into believersAnd more... Stop treating your supplement like a commodity and start giving buyers clear reasons to choose your brand over dozens of competitors, even in the crowded discount environment. This episode is essential for supplement marketers aiming to maximize e-commerce growth this holiday season.If you're interested in working with me and my team to improve your supplement business. You can learn more at my website https://creativethirst.com Click here to grab your copy of the Health Supplement Ad Swipe Guide. Discover what really works in funnel marketing Need help increasing sales on your own? Click here Stuck at $1 - $5M in revenue? Click Here Case Study on how Creative Thirst added over $200,000 for one supplement brand

In this episode of the Epigenetics Podcast, we talked with Vincent Pasque from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. We begin by tracing Vincent's journey into biology, sparked by early childhood experiences in nature and meaningful encounters with inspiring teachers. His fascination with the complexities of biology crystallized during a pivotal moment while listening to a radio segment on epigenetics in the late '90s, which led him to pursue studies in genetics and biochemistry. This formative path brought him to leading institutions, including the prestigious lab of John Gurdon, where he explored the phenomenon of nuclear reprogramming. Vincent recounts his early experiments that led to the discovery of macro H2A as a barrier to reprogramming, emphasizing the core challenge of erasing somatic cell identity. As the conversation unfolds, Vincent introduces us to critical findings from his research. He shares how the inactive X chromosome serves as a compelling model to investigate epigenetic regulation, revealing that the dynamics of reprogramming and differentiation are far from simple reversals of development. He highlights the significant differences between male and female iPSCs and how X-linked genes influence DNA methylation and differentiation rates in these cells. The implications of these findings extend beyond developmental biology to inform our understanding of diseases, particularly cancer. Transitioning to his current work, Vincent describes pioneering advances in characterizing the chromatin-associated proteome during the differentiation of human pluripotent stem cells. The surprising discovery of elevated histone modifications in naïve cells leads to intriguing questions about the barriers to cellular plasticity and the mechanisms by which cells resist alternative fate conversions. The potential applications of this research could reshape our approach to regenerative medicine and therapeutic interventions. References Pasque V, Gillich A, Garrett N, Gurdon JB. Histone variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal. 2011 May;30(12):2373-2387. DOI: 10.1038/emboj.2011.144. PMID: 21552206; PMCID: PMC3116279. Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C. R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi, K., & Gurdon, J. B. (2014). Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming. Molecular Cell, 55(4), 524–536. https://doi.org/10.1016/j.molcel.2014.06.024 Pasque V, Tchieu J, Karnik R, et al. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014 Dec;159(7):1681-1697. DOI: 10.1016/j.cell.2014.11.040. PMID: 25525883; PMCID: PMC4282187. Zijlmans DW, Talon I, Verhelst S, et al. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology. 2022 Jun;24(6):858-871. DOI: 10.1038/s41556-022-00932-w. PMID: 35697783; PMCID: PMC9203278. Related Episodes The Discovery of Genomic Imprinting (Azim Surani) Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle) Epigenetics and X-Inactivation (Edith Heard) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this episode, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, dives deep into estrone, one of the three key estrogens, and explains why understanding it is crucial for women's health. Learn about: The differences between estradiol, estriol, and estrone How estrone levels shift during perimenopause and menopause Why oral estrogen can dramatically increase estrone The impact of lifestyle factors like diet, body fat, stress, alcohol, and sedentary behavior on estrogen balance Practical tips to support healthy estrogen metabolism naturally Dr. McCarthy breaks down complex biochemistry in a clear, actionable way so you can take charge of your hormonal health.   Citations: 1. Bulun, Serdar E., et al. “Aromatase and Estrogen Biosynthesis in Adipose Tissue.” Endocrine Reviews, vol. 23, no. 3, 2002, pp. 305–342. 2. Labrie, Fernand, et al. “Importance of the Intracrinology of Estrogen Synthesis in Peripheral Tissues in Postmenopausal Women.” Journal of Steroid Biochemistry and Molecular Biology, vol. 118, nos. 4–5, 2010, pp. 273–279. 3. Sasano, Hironobu, and Toshihiko Harada. “Differential Expression of Aromatase and 17β-Hydroxysteroid Dehydrogenase Isoenzymes in Human Tissues.” Journal of Steroid Biochemistry and Molecular Biology, vol. 86, no. 3–5, 2003, pp. 327–333. 4. Yager, James D., and Nancy E. Davidson. “Estrogen Carcinogenesis in Breast Cancer.” New England Journal of Medicine, vol. 354, no. 3, 2006, pp. 270–282. 5. Cavalieri, Ercole L., and Eleanor G. Rogan. “Depurinating Estrogen-DNA Adducts, Mechanisms of Formation, and Prevention.” Clinical Cancer Research, vol. 16, no. 3, 2010, pp. 596–602. 6. Suba, Zsuzsanna. “Circulating Estrogens and Estrogen Metabolism in Obese Women.” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 11, 2013, pp. 4336–4344. 7. Simpson, Evan R., and Konstanze C. Pike. “Aromatase Expression in Adipose Tissue: Relationship to Obesity and Insulin Resistance.” Endocrinology, vol. 156, no. 9, 2015, pp. 3422–3435. 8. Key, Timothy J., et al. “Circulating Sex Hormones and Breast Cancer Risk Factors in Postmenopausal Women: Reanalysis of 13 Studies.” British Journal of Cancer, vol. 105, no. 5, 2011, pp. 709–722. 9. Stanczyk, Frank Z., et al. “Oral, Transdermal and Injectable Hormone Therapy: Pharmacokinetics and Effects on Estrone/Estradiol Ratios.” Menopause, vol. 24, no. 9, 2017, pp. 1080–1090. 10. Santen, Richard J., et al. “Estrogen Bioidentical Hormone Therapy: Route of Administration and Risk.” Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 7, 2020, pp. 2062–2074. 11. Zeleniuch-Jacquotte, Anne, et al. “Postmenopausal Levels of Estrone, Estradiol, and Estrone Sulfate and Breast Cancer Risk.” Cancer Epidemiology, Biomarkers & Prevention, vol. 23, no. 8, 2014, pp. 1531–1539. 12. Dall, Gabriella V., and Christine L. Clarke. “Local Estrogen Biosynthesis and Signaling in Breast Cancer Progression.” Steroids, vol. 78, no. 7, 2013, pp. 639–646. 13. Heald, Anthony H., et al. “Relationships Between Serum Estrone, Insulin Resistance, and Adiposity in Postmenopausal Women.” Clinical Endocrinology, vol. 67, no. 3, 2007, pp. 340–345. 14. Kuiper, George G. J. M., et al. “Estrogen Receptor β Selectivity of Estriol and Implications for Tissue-Specific Effects.” PNAS, vol. 94, no. 17, 1997, pp. 9105–9110. 15. Michnovicz, Joseph J., et al. “Dietary Indoles and Estrogen Metabolism: Effects of Cruciferous Vegetable Intake.” Journal of Nutrition, vol. 134, no. 12, 2004, pp. 3479S–   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Send Vanessa a Text MessageNEW WEBSITE: https://intentionallywellpodcast.com/In this episode, I sit down with William Parker, PhD, a scientist with decades of research in biochemistry, microbiology, and immunology. Best known for discovering the function of the human appendix and as a leading researcher studying acetaminophen (Tylenol) and its impact on neurodevelopment, William shares his insights on a topic that has recently garnered widespread media attention and public discussion, sparking conversation around acetaminophen and autism risk.We explore:How acetaminophen interacts with the body during critical periods of developmentThe biological pathways connecting acetaminophen exposure to neurodevelopmental outcomesWhy this research matters to parents, caregivers, and anyone invested in child healthCommon questions, concerns, and rebuttals surrounding acetaminophen and autism riskThe gaps in pediatric education and medical literature that often leave these risks under-discussedThis episode is designed to break down complex science in a way that is understandable, actionable, and presented through a compassionate and logical lens. Whether you're a parent, healthcare professional, or just curious, you'll walk away with a clearer understanding of the evidence, the controversies, and the implications for children's health today.For those who'd like to explore Dr. Parker's research and related literature, here are the studies and resources mentioned in this episode:Acetaminophen and Autism: Evidence from a Systematic Review (MDPI, 2024)Mechanisms of Acetaminophen-Induced Neurodevelopmental Effects (MDPI, 2024)Preprint: Revisiting Acetaminophen and Autism—A Global Call for Reevaluation (2025)Preprint: Acetaminophen, Oxidative Stress, and Neurodevelopmental Risk (2025)Prevent Autism—Educational and Research ResourceEvidence That Acetaminophen Triggers Autism in Susceptible Individuals Has Been Ignored and Mishandled for More Than a Decade (RealClear Public Health, 2025)Connect with the show:Podcast on InstagramVanessa on InstagramPodcast on YouTubePodcast on TikTokPodcast on XEmail: intentionallywellpodcast@gmail.comSupport the ShowIf this podcast has encouraged you and you'd like to help me continue sharing impactful content, you can support the show here:Support the Show© 2025 Vanessa Lopez, Intentionally Well Podcast. All rights reserved. No part of this podcast or show notes may be copied, shared, oSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

Why does it work? Proposed biomedical effect mechanisms of exercise-based injury prevention programmes in football (Soccer) and handball: a scoping review of 104 studies Moen C, Myklebust G, Munkvold E, et al. Br J Sports Med. 2025;59(20):1435-1442. doi:10.1136/bjsports-2025-109802 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest VALD MoveHealth - https://movehealth.me/ Learn more about/Buy Erik/Jason/Chris's courses – The Science PT Support us on the Patreons! Music for PT Inquest: "The Science of Selling Yourself Short" by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux

Creatine's story has been far too small for its biology. Most people still see it as a supplement for strength or cognitive performance, but its most important work happens inside the mitochondria.In this episode, we explore a side of creatine few people talk about: how it may function as mitochondrial medicine. We'll break down 3 distinct ways creatine acts in and supports the mitochondria; roles that could reshape how we think about energy, resilience, and cellular health.  And beyond that, how creatine may be one of the few molecules that can both diagnose and treat mitochondrial dysfunction. 00:00 Understanding Mitochondrial Dysfunction00:43 Introduction to Creatine's Role01:16 Mitochondrial Dysfunction Explained01:56 Creatine as a Theranostic Agent02:57 Mechanisms of Creatine in Mitochondria04:09 Therapeutic Roles of Creatine05:22 Redox Control and Antioxidant Properties06:27 Conclusion: The Unique Power of Creatine PMID: 40948982

Send us a textEver wonder why some moments with your child feel effortless and deeply connected — while others leave you drained, reactive, or misunderstood? In this episode, we break down the science behind why.Dr. Jessie Stern and psychologist Rachel Samson join Cindy to explore relational savoring — a simple yet powerful way to strengthen your bond by intentionally remembering moments of warmth, safety, and love. You'll learn how this practice calms your nervous system, reduces stress, and builds emotional security — for both you and your child.They also unpack the role of temperament and sensitivity in relationships. Why do some people (and kids) feel everything more deeply? What does that mean for how we connect, comfort, and communicate?If you've ever said, “I wish I could stay calm when things get hard,” this conversation will give you the science and the self-awareness to start doing exactly that.Because connection isn't about perfection — it's about noticing, savoring, and showing up with compassion.Read their new book: Beyond Difficult: An attachment-based guide to dealing with challenging peopleFollow Rachel SamsonFollow Dr. Jessie SternRead the science article: Savoring interventions for mothers of young children: Mechanisms linking relational savoring and personal savoring to reflective functioningListen to more podcast episodes:https://podcasts.apple.com/ca/podcast/reflective-parenting-by-curious-neuron/id1440533170?i=1000731541535Support the showJoin our Reflective Parenting Program to learn the science-based skills parents (and their kids) need to thrive: https://curiousneuron.com/reflective-parent-club/ Record your question, or share a parenting insight in a 1 min audio we will share on the podcast https://www.speakpipe.com/ReflectiveParentingPodcast Book a spot in my calendar to chat about your challenges: https://calendly.com/curious_neuron/chat-with-cindy-reflective-parent-club-clone Grab a Free Resource: FREE Workbook: Staying Calm When Your Child Isn't: A Parent's Guide to Triggers and Emotions Email: info@curiousneuron.com

What if the key to solving the mysteries of modern physics lies not in new mathematics, but in a physical interpretation of the mathematics we already have?This week, we begin a deep, two-part conversation with Dr. Chantal Roth about the Elastic Aether Theory—one of the first serious contenders we've found for a material interpretation of fundamental physics. Dr. Roth's quest for a deeper understanding of the universe begins by taking the mathematics of General Relativity, applying a set of material science axioms, and deriving what the mathematics of light and gravity tell us about the physical properties of the universe. Check out part 2, where we dive into the ether-based mechanisms for mass, light, charge, electricity, and gravity. PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showHOMEBREW MUSIC - Check out our new album!Hard Copies (Vinyl): FREE SHIPPING https://demystifysci-shop.fourthwall.com/products/vinyl-lp-secretary-of-nature-everything-is-so-good-hereStreaming:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-here00:00:00 Go!00:01:05 Introduction to Quantum Mechanics and Elastic Aether Theory00:05:24 The Quest for Understanding in Quantum Physics00:10:12 Perspectives on Aether and Spacetime00:15:57 Properties of Space: Elastic Solid Analogy00:20:48 Newton's Vision of Aether as a Mediator00:21:53 Newton's Ideas on Gravity and Refraction00:24:11 Mechanisms of Refraction and Light Behavior00:28:11 Limitations of Analogies in Wave Behavior00:33:58 Historical Context and Physics Connections00:37:26 The Concept of Metric Tensor in Space00:41:21 Discussion on the Constancy of Light Speed00:45:04 Mechanical Explanation of Wave Speed00:50:12 Interconnectedness and the Nature of Matter00:55:56 Refractive Index and Its Role in Gravity00:59:50 Examination of Atom Composition and Aether01:01:52 Introduction to Waves and Ether01:05:00 Wave Patterns and Their Implications01:09:00 Density and Stiffness in the Aether01:13:00 The Nature of Light Near Massive Objects#quantummechanics , #ElasticEtherTheory, #modernphysics , #physicsexplained , #theoreticalphysics , #historyofscience , #alberteinstein , #isaacnewton , #spacetime , #generalrelativity , #quantumphysics , #waveparticleduality , #cosmology , #light , #mindscape , #stringtheory , #mechanics MERCH: Rock some DemystifySci gear : https://demystifysci-shop.fourthwall.com/AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Dietitians Torwen Eerkens discuss the impact of carbohydrates on sleep quality, exploring various mechanisms, the timing and type of carbohydrates, and practical recommendations for incorporating carbs into the evening routine.  (00:27) - Mechanisms and Research Background (02:14) - High GI vs Low GI Carbohydrates (6:00) - Carbohydrate Quantity  (6:48) - Potential Downsides to Adding Carbs Before Bed  (8:55) - Practical Recommendations  (10:23) - Tart Cherry Juice WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en Our dietitians

In this week's episode of the Blood Podcast, Associate Editor Dr. James Griffin interviews Drs. Binod Dhakal and Ruben Bierings about their respective papers published in this week's issue of Blood. Dr. Dhakal presents his study on using talquetamab, a bispecific antibody, as a bridging therapy before BCMA-targeted CAR T-cell therapy in multiple myeloma patients, showing promising results with high response rates and manageable toxicities. Next, Dr. Bierings identified patients with genetic variants in the guanine exchange factor MAP kinase–activating death domain (MADD) that impair VWF secretion from endothelial cells and possibly cause VWD type 1. Featured ArticlesA novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variantsSophie Hordijk, Stijn A. Groten, Petra E. Bürgisser, Sebastiaan N. J. Laan, Georg Christoph Korenke, Tomáš Honzík, Diane Beysen, Frank W. G. Leebeek, Paul A. Skehel, Maartje van den Biggelaar, Tom Carter, Ruben BieringsSequential targeting in multiple myeloma: talquetamab, a GPRC5D bispecific antibody, as a bridge to BCMA CAR-T therapyBinod Dhakal, Othman S. Akhtar, David Fandrei, Alexandria Jensen, Rahul Banerjee, Darren Pan, Shambavi Richard, Reed Friend, Matthew Rees, Patrick Costello, Mariola Vazquez Martinez, Oren Pasvolsky, Charlotte Wagner, James A. Davis, Omar Castaneda Puglianini, Ran Reshef, Aimaz Afrough, Danai Dima, Manisha Bhutani, Omar Nadeem, Ricardo Parrondo, Ciara Freeman, Lekha Mikkilineni, Shahzad Raza, Larry D. Anderson Jr, Prashant Kapoor, Hitomi Hosoya, Saurabh Chhabra, Ariel Grajales-Cruz, Mahmoud Gaballa, Shonali Midha, Melissa Alsina, Douglas Sborov, Krina Patel, Yi Lin, Christopher Ferreri, Nico Gagelmann, Anupama Kumar, Doris Hansen, Andrew Cowan, Luciano J. Costa, Maximilian Merz, Surbhi Sidana

Send us a textIn this episode of PT Snacks podcast, we continue our discussion on the sacroiliac (SI) joint, discussing optimal manual techniques and exercises to help patients experiencing SI joint pain. We'll break down the function of the SI joint, explore the latest research on manual therapy, and explain why a combination of manual therapy and exercise is most effective. Join us as we cover high-level reviews and specific techniques to help your patients move better and feel better. Don't forget to hit the subscribe button, leave a review, and check out the special MedBridge discount in the show notes!00:00 Introduction and Podcast Overview00:26 Listener Feedback and Today's Topic Introduction01:29 Understanding the Sacroiliac (SI) Joint02:03 Manual Therapy Techniques for SI Joint05:52 Mechanisms and Theories Behind Manual Therapy13:46 Exercises for SI Joint Stabilization15:44 Combining Manual Therapy and Exercise16:57 Conclusion and Additional ResourcesTrager RJ, Baumann A, Rogers H, et al. Efficacy of manual therapy for sacroiliac joint pain syndrome: a systematic review and meta-analysis of randomized controlled trials. J Man Manip Ther. 2024;32(2):71-85.Nejati P, Safarcherati A, Karimi F. Effectiveness of exercise therapy and manipulation on sacroiliac joint dysfunction: a randomized controlled trial. Pain Physician. 2019;22(1):53-61.Kamali F, Zamanlou M, Ghanbari A, Alipour A, Bervis S. Comparison of manipulation and stabilization exercises in patients with sacroiliac joint dysfunction: a randomized clinical trial. J Bodyw Mov Ther. 2019;23(1):177-182.Bialosky JE, Bishop MD, Price DD, Robinson ME, George SZ. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. J Orthop Sports Phys Ther. 2009;39(3):123-130.Testa M, Rossettini G. Enhance placebo, avoid nocebo: how contextual factors affect physiotherapy outcomes. Phys Ther. 2016;96(11):1541-1549.Shahali S, Ebrahimian MR, Hosseinifar M, et al. Effects of motor control exercise on pain and disability in patients with sacroiliac joint pain: a systematic review and meta-analysis. Musculoskelet Sci Pract. 2021;56:102419.Visser LH, Woudenberg NP, de Bont J, et al. Treatment of the sacroiliac joint in patients with leg pain: a randomized controlled trial. Eur Spine J. 2Go to PT Final Exam using this link to access great studying options to conquer the NPTE!Support the showStay Connected! Follow so you never miss an episode. Send your questions via email to ptsnackspodcast@gmail.com Join the email list HERE Need CEUs or NPTE Prep? Save over $100 on unlimited CEUs with MedBridge using code PTSNACKSPODCAST at checkout. Students: Get a full year of access for less with code PTSNACKSPODCASTSTUDENT. Prepping for the NPTE? PT Final Exam offers all the tools you need. Use code PTSnacks at checkout to get a discount! Support the ShowShare the episode with someone who'd benefit. Contributing directly to the "support" link. Thanks for tuning in—your support makes this all possible!

Sen and Erica welcome Sarah Shipp as she hosts her Thinking Beyond Mechanism series. In this episode, she discusses the permissions that games and their rules give us to break social conventions within the construct of the so-called "Magic Circle".

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Injectable Glutathione: 2025 Update & Comprehensive GuideHey everyone, it's Hunter Williams here! In today's video, I bring you my 2025 update on glutathione, particularly injectable glutathione. I've used it for years and continue to be amazed by its benefits. This video expands on my previous content with newer clinical evidence and informed recommendations. We'll discuss its role in mitigating the effects of mitochondrial peptides, combating environmental stressors, and maintaining liver health. I'll delve into the bioavailability challenges of oral glutathione versus injectables, specific use cases like liver disease, male fertility, and even chemotherapy support. Plus, I'll share how to properly administer it, monitor its effects, and my personal insights on how it enhances energy, immune function, and overall well-being. Don't miss out on this detailed and informative guide—perfect for anyone into peptide research or looking to optimize their health! As always, check the links in the description, and don't forget to join my email list for updates. Thanks for your continuous support. Let's dive in!00:00 Introduction and Video Overview02:39 What is Glutathione?03:47 Bioavailability and Delivery Methods06:06 Mechanisms of Action and Benefits08:41 Clinical Applications and Case Studies25:27 Dosing Guidelines and Best Practices28:48 Conclusion and Final Thoughts

Radhika Das, IFN Journalist, interviews Fahad Hamad Al-Sulaiti, Director General, Qatar Fund For Development (QFFD), on the role QFFD sees for the private sector in scaling impact through different financing mechanisms and the organization's Islamic finance involvement

CODEPINK World Court Campaign Coordinator Robert Jereski: After Gaza Hostage/Prisoner Exchange, Ceasefire Lacks Enforcement MechanismsU.S. Marine veteran Bryce Lockwood: Recounting Israel's 1967 Attack on U.S. Research Ship during Six-Day War and Its Lasting ImpactFormer health insurance executive turned whistleblower Wendell Potter: Federal Government Shutdown Exposes Crisis in Long Failing U.S. Healthcare SystemBob Nixon's Under-reported News Summary• Brazil's Jair Bolsonaro, convicted of coup plot, running out of options• Russia, Vietnam can avoid U.S. sanctions with backdoor energy enterprise• Puerto Ricans' mutual aid food system could be a model post-natural disastersVisit our website at BTLonline.org for more information, in-depth interviews, related links and transcripts and to sign up for our BTL Weekly Summary. New episodes every Wednesday at 12 noon ET, website updated Wednesdays after 4 p.m. ETProduced by Squeaky Wheel Productions: Scott Harris, Melinda Tuhus, Bob Nixon, Anna Manzo, Susan Bramhall, Jeff Yates and Mary Hunt. Theme music by Richard Hill and Mikata.

Cancer now affects 30% to 50% of Americans, a massive increase from just 5% in 1900, reflecting how modern diets and lifestyles have reshaped your body's internal terrain Excess linoleic acid (LA) from seed oils triggers toxic byproducts, chronic inflammation, and mitochondrial breakdown, all of which weaken your body's defenses and fuel tumor growth Lowering LA intake from 7% to around 2% to 3% of daily calories has been shown to cut oxidative stress markers by 20% in as little as 12 weeks, giving your body a chance to recover A four-phase terrain restoration strategy uses seed oil elimination, staged carbohydrate reintroduction, gradual fiber restoration, and metabolic supports like intermittent fasting and exercise to rebuild resilience Simple daily steps — avoiding seed oils, rebuilding gut health, supporting mitochondria through movement and sleep, and tracking progress — give you control over your risk and long-term health

Sodium bicarbonate is one of the most consistently supported ergogenic aids in sports nutrition research, yet its underlying mechanisms and real-world applications remain widely misunderstood. More recent developments have focused on how to optimise both the timing and formulation of supplementation. The “individualised ingestion timing” approach has emerged as a practical strategy, recognising that the time-to-peak blood bicarbonate concentration varies considerably between individuals. Similarly, novel formulations are being explored to address issues with gastrointestinal distress and practicality of dosing. These include topical approaches such as sodium bicarbonate lotion, and commercial products like Maurten's “Bicarb System.” In this episode, Prof. Lewis Gough joins to discuss the latest evidence on sodium bicarbonate and performance, its mechanisms, novel delivery systems, and the key directions for future research. Dr. Lewis Gough is Associate Professor in Nutrition and Physiology at Birmingham City University. He is globally recognized for his research on sodium bicarbonate supplementation in sport, and his work spans applied sport and exercise nutrition, exercise metabolism, acid–base balance, and fatigue. Timestamps [03:12] Professor Gough's academic journey [06:29] Mechanisms of sodium bicarbonate and historical perspective on lactate [11:21] Sodium bicarbonate's role in performance [22:45] Individual responses to sodium bicarbonate [26:53] Timing strategies for sodium bicarbonate [32:38] Individualized approach to sodium bicarbonate timing [36:47] Traditional vs. novel delivery methods [44:27] Practical recommendations for athletes [51:18] Future research directions [01:02:08] Key Ideas segment Resources Go to episode page (w/ links to relevant studies) Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course See all of Sigma's "Recommended Resources"

Sam Miller is a respected educator and authority on metabolism and founder of Metabolism School. Sam guests on my podcast to share his expertise on:-The implications of the dramatic rise in GLP-1 Agonist medication use -The situations where GLP-1 Agonist medication use makes sense and where it's inappropriate -Potential benefits outside appetite suppression and weight loss-Nuance about the potential side effects -The importance of strength training when using these drugs-Reverse dieting, what it is, when it's appropriate -Situations where reverse dieting may be harmful -The role ultra processed foods play in the obesity and metabolic unhealth epidemic -Are all ultra processed foods problematic-And much more00:30 GLP-1 Medications: Popularity and Usage01:33 Mechanisms and Effects of GLP-103:10 Broader Implications and Side Effects11:26 Resistance Training and Muscle Preservation17:44 Nuances of GLP-1 Use in Different Populations27:15 Famous Athletes and Weight Struggles27:41 The Trend of Reverse Dieting28:39 Concerns with Reverse Dieting30:57 Effective Reverse Dieting Strategies43:11 The Role of Ultra-Processed Foods in Health51:58 Conclusion and ResourcesI've been putting a lot of time and effort into making these new episodes valuable for you. You can help me get these great guests and their knowledge in front of more people by:-Subscribing and checking out more episodes-Sharing on your social media (please tag me - I promise I'll respond)-Sharing with the friend you think of who needs this episodeFollow Andrew Coates:Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@andrewcoatesfitness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Join My Email List:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.andrewcoatesfitness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get the RP App at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.rpstrength.com/coates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - use the code COATESRPUse Code ANDREWCOATESFITNESS to save 10% off at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://justbitememeals.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Use MacrosFirst for tracking nutrition ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.macrosfirst.com/⁠⁠Go to www.knkg.com/Andrew59676 for 15% off your KNKG bag.Get a discount on Versa Gripps at www.versagripps.com/andrewcoates

In this episode, Dr. Shaun Jackson uses a compelling patient case to illuminate the complex mechanisms of immune tolerance and autoimmunity. He explains how B cells learn to avoid targeting the body's own tissues through central and peripheral tolerance—and how these safeguards can fail. The discussion covers the roles of germinal centers, T cells, and rare genetic disorders in shaping immune regulation, with Alport's syndrome and post-transplant Goodpasture's disease serving as striking examples. Dr. Jackson also reflects on emerging directions in autoimmune research and shares his journey from medical training in South Africa to leading a research program in Seattle, offering valuable insights for future physician-scientists. 

Professors Bas Bloem and Werner Poewe explore the underlying mechanisms of Parkinson's disease and discuss current and emerging therapeutic approaches. A clear and insightful conversation for anyone seeking to better understand the science behind PD and its treatment.

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Timestamps00:00 Introduction and Video Overview00:14 Oxytocin and Its Connection to Fat Loss01:16 Scientific Data and Research on Oxytocin02:30 Mechanisms of Oxytocin in Fat Loss04:23 Oxytocin's Effects on Appetite and Metabolism05:29 Comparing Oxytocin with Other Weight Loss Aids10:37 Direct Actions of Oxytocin on Fat Cells11:59 Animal and Human Studies on Oxytocin19:26 Oxytocin Usage Protocols24:33 Potential Side Effects and Safety26:56 Conclusion and Final ThoughtsJoin me, Hunter Williams, as I delve into the fascinating connection between oxytocin—the 'love hormone'—and its surprising benefits for fat loss. Discover the scientific data and practical insights that show how this peptide hormone can enhance muscle preservation, improve metabolism, and reduce cravings for high-fat foods. Learn the optimal ways to use oxytocin, including dosing protocols and the synergy with diet and exercise. Don't forget to stay connected by joining my email list for updates on new videos and content. Let's dive in and explore how oxytocin can support your fitness and wellness journey!

Featuring an interview with Dr Ghayas Issa, including the following topics: Mechanism of action and efficacy of menin inhibitors (0:00) Presentation and management of differentiation syndrome (13:31) Role of menin inhibitors in other cancers (18:19) Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51) Mechanisms of resistance to menin inhibition in AML (26:53) Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31) Mechanism of action of menin inhibitors as differentiation agents (38:05) Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55) Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25) Other investigational therapeutic strategies in AML (54:39) CME information and select publications

Featuring a slide presentation and related discussion from Dr Ghayas Issa, including the following topics: Evolution of menin inhibitors for acute myeloid leukemia (AML) (0:00) Side effects of menin inhibition (10:54) Mechanisms of resistance to menin inhibition in AML (15:08) CME information and select publications

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/00:00 Introduction and Video Overview00:20 Personal Experience with SS 3101:43 Scientific Basis and Human Trials03:25 Mechanisms of SS 3107:37 Clinical Applications and Benefits14:46 Dosing Guidelines and Safety21:21 Emerging Applications and Future Potential26:51 Conclusion and Final ThoughtsIn this comprehensive deep dive into SS-31, I'll be sharing my personal experience with this powerful mitochondrial peptide, its scientific mechanisms, clinical applications, dosing guidelines, and the outstanding benefits observed in various human trials. Whether you're looking to enhance your energy levels, improve athletic performance, or support your cardiovascular and cognitive health, SS-31 offers promising solutions. Don't miss out on this essential biohacking tool!

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business.    In this episode, Megan Thomas is in conversation with Thibaud Portal, Founder and COO of Alys Pharmaceuticals, a biotech launched in 2024 with a landmark $100 million seed round. The conversation explores the vision behind founding Alys, the role of strategic collaborations with leading scientists, and the rationale for building a diversified dermatology pipeline spanning atopic dermatitis, systemic mastocytosis, and rare conditions such as Cold Urticaria.  You can listen below, or find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts. 

Lockboxes promise price certainty—but the clock can quietly shift value. In this episode, Mike and Ryan break down how a lockbox differs from a classic cash-free/debt-free (CF/DF) deal: fixed price as of a “lockbox date,” no post-close true-up, and a tight definition of permitted vs. non-permitted leakage. They discuss when lockboxes shine (fast closings, cleaner accounting, fewer surprises) and where sellers need to be careful (growth between lockbox date and close often accrues to the buyer). You'll get apples-to-apples comparison tips for evaluating offers, what to watch in tax escrows, and a practical way to translate excess working capital into headline price. If you've ever wrestled with working capital adjustments or wanted a cleaner close, this one's your field guide.Seller checklist:Nail down the lockbox date and permitted leakage list.Quantify excess working capital and reflect it in price.Set a close timeline—faster is safer for sellers.Align on tax items and escrow triggers.Ensure every CF/DF vs. lockbox offer is compared on the same basis. RELATED EPISODES: Episode 154: What will be your take home portion of the deal? Listen now >>Episode 123: Understanding Cash Free Debt Free in M&A Transactions. Listen now >>Episode 100: Looking back at 100 Episodes and Narrowing in on Working Capital. Listen now >>Episode 94: Navigating Undisclosed Liabilities Before, During, and After Close. Listen now >>  Listen to Shoot the Moon on Apple Podcasts or Spotify.Buy, sell, or grow your tech-enabled services firm with Revenue Rocket.

Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Systematic Review Findings: Cochrane umbrella review of 9 systematic reviews (51 trials; n=2,895) comparing active TENS with sham/usual care found uncertain efficacy due to: Very low-quality evidence (risk of bias, small samples, methodological limitations). Inconsistent adverse event reporting. Heterogeneity in TENS parameters and comparators. Authors note uncertainty may be confounded by inadequate dosing not being an inclusion metric. Practical Interpretation: TENS is inexpensive, low-risk, self-administered, and titratable; commonly used by patients and physical therapists. Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter.   David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References  Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923.   Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp 

Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter.   David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References  Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923.   Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp 

Project Sync / Status Update Summary Podcast Episode Overview The host discussed Transcutaneous Electrical Nerve Stimulation (TENS) as a recurring pain board topic and reviewed mechanisms, efficacy, and clinical considerations. Emphasis that TENS appears on pain boards annually and is a foundational topic from early podcast episodes. Board Prep and NRAP Community at PainExam.com or NRAPpain.org ABA ABPM ABIPP FIPP Pain Management Board prep, Question Banks, and Virtual Pain Fellowship Educational Offerings and Events Training and Courses: Monthly ultrasound courses in New York and upcoming courses in Detroit covering ultrasound-guided regional anesthesia and chronic pain. Ultrasound Guided Acute and Chronic Pain course in November near Hollywood/Fort Lauderdale with venue pending confirmation. Multiple instructors to offer diverse perspectives; registration via the CME calendar at nrappain.org. Conferences and Teaching: New York–New Jersey Pain Conference in November (hosted by Soudir Duwan). ISPN conference in London next week, with ultrasound teaching participation by the host. Community and Coaching: Private coaching and shadowing opportunities available; contact via newsletter replies. Access to the NRAP community forum upon signup at nrappain.org for discussions on neuromodulation, regional anesthesia, and pain. TENS: Mechanisms and Parameters Device and Parameters: TENS delivers adjustable pulse frequency and intensity; configurations include low (50–100+ Hz), and mixed frequencies. Mechanisms of Analgesia: Activation of large-diameter, non-noxious A-beta afferent fibers in the periphery, driving descending inhibitory pathways and reducing hyperalgesia. Board-relevant point: selective activation of A-beta fibers is frequently tested. Central effects: Reduces central excitability and nociceptive dorsal horn neuron activity in uninjured and injured models. Frequency-dependent opioid receptor mediation: High-frequency analgesia blocked by delta receptor antagonists. Low-frequency analgesia blocked by mu receptor antagonists (spinal cord and rostral ventral medulla). Additional receptor involvement: muscarinic M1/M3, GABA-A, and cannabinoid (CB1) receptors; blockade reduces or prevents TENS analgesia depending on frequency. Peripheral effects: High-frequency TENS reduces injury-related increases in substance P in DRG neurons. Blockade of peripheral opioid and CB1 receptors can prevent analgesia from both low- and high-frequency TENS. Clinical dosing considerations: Adequate dosing (timing, frequency of use, intensity achieving strong but non-painful paresthesia) influences efficacy. Analgesia has rapid onset/offset and may require repeated administration throughout the day for sustained relief. Evidence and Efficacy Summary Practical Interpretation: TENS is inexpensive, low-risk, self-administered, and titratable; commonly used by patients and physical therapists. Clinical experience suggests potential adjunctive benefit for acute pain, but systematic reviews are conflicting; more rigorous studies are needed. For board preparation, the critical takeaway is A-beta fiber activation. Key Takeaways for Board Prep TENS targets large-diameter non-noxious A-beta afferents to reduce nociceptive signaling. High-frequency TENS: analgesia mediated via delta opioid receptors; blocked by delta antagonists. Low-frequency TENS: analgesia mediated via mu opioid receptors; blocked by mu antagonists in spinal cord and RVM. Additional receptor systems influencing TENS efficacy include muscarinic (M1/M3), GABA-A, and CB1. Action Items Review TENS mechanisms with emphasis on A-beta fiber activation for board prep. Verify and publish final venue details for the November Florida ultrasound course. Share registration links and schedules for Detroit and New York ultrasound and chronic pain courses via CME calendar. Prepare teaching materials for ISPN London ultrasound sessions next week. Update board prep resources on painexam.com and nrappain.org with current TENS evidence and dosing guidance. Promote NRAP community forum access and private coaching/shadowing opportunities through the newsletter.   David Rosenblum, MD, currently serves as the Director of Pain Management at Maimonides Medical Center and AABP Integrative Pain Care.  As a member of the Department of Anesthesiology, he is involved in teaching, research, CME activities, and was key faculty in developing the anesthesiology residency's regional anesthesia block rotation, as well as institutional wide acute and chronic pain management protocols to ensure safe and effective pain management. He currently is a managing partner in a multi-physician private pain practice, AABP Integrative Pain Care, located in Brooklyn, NY. He is one of the earliest interventional pain physicians to integrate ultrasound guidance to improve the safety and accuracy of interventional pain procedures. Patients can go to www.AABPpain.com or call 718 436 7246 Awards New York Magazine: Top Doctors: 2016, 2017, 2018, 2021, 2022, 2023, 2024, 2025 Schneps Media: 2015, 2016, 2017, 2019, 2020 Top Doctors New York Metro Area (digital guide): 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023 2025 Schneps Media - Brooklyn Courier Life: 2021, 2022, 2023 References  Johnson M. Transcutaneous Electrical Nerve Stimulation: Mechanisms, Clinical Application and Evidence. Rev Pain. 2007 Aug;1(1):7-11. doi: 10.1177/204946370700100103. PMID: 26526976; PMCID: PMC4589923.   Vance, C.G.T.; Dailey, D.L.; Chimenti, R.L.; Van Gorp, B.J.; Crofford, L.J.; Sluka, K.A. Using TENS for Pain Control: Update on the State of the Evidence. Medicina 2022, 58, 1332. https://doi.org/10.3390/medicina58101332 #painnyc #painbrooklyn #prpbrooklyn #prpspine #regionalanesthsia #pccwindsor #paincareclinicswindsor #painwindsorontario #paindocwindsorontarior #paincareclinics #prpwindsorontario #prp 

Featuring an interview with Dr Kevin Kalinsky, including the following topics: Patient-Reported Outcomes from the TROPION-Breast01 Study (0:00) Pernas S et al. Datopotamab deruxtecan (Dato-DXd) vs chemotherapy (CT) in previously treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer (BC): Patient-reported outcomes from the TROPION-Breast01 study. ASCO 2024;Abstract 1006. Indirect Comparison of Sacituzumab Govitecan and Datopotamab Deruxtecan for Advanced Breast Cancer (5:04) Pathak N et al. Indirect comparison of sacituzumab govitecan (SG) and datopotamab deruxtecan (Dato-DXd) in advanced breast cancer (aBC): Safety and efficacy analysis. San Antonio Breast Cancer Symposium 2024;Abstract P1-02-02. BEGONIA: A Phase Ib/II Study of Datopotamab Deruxtecan with Durvalumab as First-Line Treatment for Unresectable Advanced Triple-Negative Breast Cancer (9:53) Schmid P et al. Datopotamab deruxtecan (Dato-DXd) + durvalumab (D) as first-line (1L) treatment for unresectable locally advanced/metastatic triple-negative breast cancer (a/mTNBC): Updated results from BEGONIA, a phase Ib/II study. ESMO 2023;Abstract 379MO. Advances in the Use of TROP2-Targeted Antibody-Drug Conjugates for Breast Cancer: Mechanisms, Clinical Applications and Future Directions (15:35) Tong Y et al. Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: Mechanisms, clinical applications, and future directions. Front Immunol 2024;15:1495675. Abstract CME information and select publications

Send us a textIn this episode of PT Snacks podcast, we dive deep into scaphoid fractures, a common yet often mismanaged injury in younger and active individuals. Listeners will learn about the anatomy of the scaphoid bone, the typical mechanisms of injury, common diagnostic challenges, and both conservative and surgical treatment options. We explain the importance of recognizing and adequately managing these fractures to prevent complications like avascular necrosis and non-union. Tune in to enhance your knowledge and clinical skills regarding this significant topic in physical therapy.00:00 Introduction and Welcome00:44 Topic Overview: Scaphoid Fractures01:21 Anatomy of the Scaphoid03:29 Mechanisms and Risk Factors04:27 Diagnosis and Imaging05:11 Differential Diagnosis05:59 Symptoms and Clinical Examination06:36 Treatment Options07:40 Conclusion and Additional ResourcesReferencesSteinmann S, et al. Scaphoid fractures and nonunions: diagnosis and treatment. J Orthop Sci. 2006.Rhemrev S, et al. Current methods of diagnosis and treatment of scaphoid fractures. Int J Emerg Med. 2011.Clementson M, et al. Acute scaphoid fractures: guidelines for diagnosis and treatment. EFORT Open Rev. 2020.Krasin E, et al. Review of the current methods in the diagnosis and treatment of scaphoid fractures. Postgrad Med J. 2001.Krimmer H, et al. [Scaphoid fractures—diagnosis, classification and therapy]. Unfallchirurg. 2000.Clementson M, et al. [Scaphoid fractures – Guidelines for diagnosis and treatment]. Lakartidningen. 2019.Pickrell BB, et al. Update on management of scaphoid fractures. Plast Reconstr Surg. 2024.Go to PT Final Exam using this link to access great studying options to conquer the NPTE!Support the showStay Connected! Make sure to hit follow now so you don't miss an episode! Got questions? Email me at ptsnackspodcast@gmail.com or leave feedback HERE. You can also join the email list HERE Need CEUs Fast?Time and resources short? Medbridge has you covered: Get over $100 off a subscription with code PTSNACKSPODCAST: Medbridge Students: Save $75 off a student subscription with code PTSNACKSPODCASTSTUDENT—a full year of unlimited access for less! Prepping for the NPTE? Get all the study tools you need to master it at PT Final Exam. Use code PTSnacks at checkout to get a discount! Want to Support the Show?Help me keep creating free content by: Sharing the podcast with someone who'd benefit. Contributing directly via the link...

Most doctors dream about leaving the ER grind, but here's what's remarkable: Dr. Nico Grundmann didn't just escape - he built something that's actually changing how we think about mental healthcare at scale.In this conversation, Sam sits down with Dr. Grundmann, an emergency physician who took his systems-thinking background and created something unprecedented: a five-location ketamine practice that's generating the kind of data insurance companies actually pay attention to. We're talking about going from solo practitioner to managing 30 team members while maintaining the clinical rigor that makes this work sustainable.What makes this conversation essential listening? Dr. Grundmann's approach shows exactly how individual practices can drive policy-level change - but it requires thinking beyond your patient panel to the broader healthcare system. His story proves that with the right framework, you can build something that's both profitable and positioned to influence national coverage decisions.If you've ever wondered how to scale beyond a single clinic without losing clinical quality, or if you're curious about what it really takes to collect data that insurance companies respect, this conversation will give you the roadmap you need.What You'll Learn in This Episode

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this video, I break down ATX-304 (also known as OS-01 or OS-03) — a powerful small molecule AMPK activator being studied for fat loss, metabolic health, and longevity. If you've heard ATX-304 described as “exercise in a capsule,” you'll see why after going through the research, mechanisms, human trials, and potential applications.I also share how ATX-304 works differently than GLP-1s, why it preserves muscle while supporting fat loss, and what the future may hold for this compound in anti-aging medicine.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/0:00 - Intro: why I'm covering Testagen0:30 - The low-T epidemic and TRT context1:12 - Why I'm excited about Testagen vs HCG2:00 - What I'll cover today (what it does, dosing, use cases)2:40 - What Testagen is (KEDG bioregulator peptide)3:12 - Mechanisms and “does this help women?” note4:00 - Core effects: endocrine support + epigenetic action5:00 - Target tissues: pituitary, thyroid, testes, bone marrow6:00 - Vascular/erectile benefits; “calibrating” the HPT axis6:30 - Fertility use case + my personal plan7:16 - Manufacturer indications; sexual function improvements8:12 - Case study: semen parameters quadrupled on Testolutin8:58 - Thyroid support, TBI/central hypo considerations9:58 - Anti-aging & immune modulation overview10:20 - Human evidence: oral Testolutin study (TT, LH/FSH ↑)11:02 - Human evidence: IM Testagen (2.5 mg x 10 days) results11:48 - 2022 combo study (4-peptide stack; free T ↑ ~54%)13:08 - Animal data: pituitary-independent thyroid restoration14:08 - Cell data: nuclear entry, histone/DNA binding14:34 - Outcomes summary: testosterone, LH/FSH, libido15:02 - Testagen vs TRT; stacking with Epitalon/Epithalamin16:01 - Safety profile: “no significant side effects” noted16:56 - Dosing protocol I recommend (2 mg/day, 10–60 days)17:24 - Full male-health stack ideas (Testagen + others)17:40 - Big-picture takeaway: who benefits most18:10 - Real-world reports, call for comments, and thanksI break down Testagen (a KEDG bioregulator) as a legit pathway to support testicular function, HPT axis “calibration,” and fertility—without typical TRT downsides. I walk through how it works at the epigenetic level (nuclear entry, histone/DNA interaction), human and animal evidence (oral Testolutin and injectable Testagen), thyroid and immune benefits, erectile/vascular support, and what I've seen in early adult men with low T. I also share my fertility plan, practical dosing (2 mg/day; 10–60 days), and how I'd pair Testagen with peptides like Epitalon, Libidon, Glandokort, and Superfort for broader rejuvenation. If you've used Testagen, drop your experience—wins or misses—so we can help the community learn what's working.

In Episode 266 we discuss mechanisms and board games that were inspired by the theme they represent.Dave Beck (designer of Distilled and Luthier) also joins us for the discussion and gives us a sneak peak at the upcoming Distilled expansion, Distilled: Cocktails.Timestamps:00:00 Introduction01:06 Distilled: Cocktails15:14 Theme Driven Mechanisms17:25 Obsession19:39 Woodcraft21:35 Captain Sonar28:25 Hegemony: Lead Your Class To Victory36:14 Wingspan, The Fox Experiment37:33 Viticulture, Scoville40:23 Western Legends45:08 Baseball Highlights 2045, Barrage49:35 Nemesis, Batman: Gotham City Chronicles51:33 Android: Netrunner54:43 Flamme Rouge, Heat: Pedal to the MetalIf you enjoy the show, please consider supporting us at https://www.patreon.com/boardgamehottakesFollow us on BlueSky: https://bsky.app/profile/boardgamehottakes.bsky.socialJoin our Board Game Arena Community: https://boardgamearena.com/group?id=11417205Join our Discord server at: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://discord.gg/vMtAYQWURd

Sen and Erica welcome Sarah Shipp as the host of the Thinking About Mechanisms segment. This episode, Sarah talks about social distance as one of the main differentiators between video games and tabletop games.

Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity. What You'll Learn: Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health. Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research. Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss. Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions. Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane. Key Takeaways: SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management. Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies. The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity. Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions. Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one’s own biology in response to health interventions. Resources: Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig Substack: https://jonbrudvig.substack.com/ Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience. Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being. 00:12 Understanding SGLT2 Inhibitors 02:51 Mendelian Randomization and SGLT2 Inhibitors 06:24 Benefits and Mechanisms of SGLT2 Inhibitors 09:47 Discussion on Metformin 14:36 Intermittent Fasting and Ketone Supplements 17:46 Fasting, Autophagy, and Muscle Health 22:38 Exploring Glycine and N-Acetyl Cysteine 24:48 Microplastics: A Growing Concern 26:25 The Impact of Microplastics on Health 31:54 Self-Experimentation with Sulforaphane 38:33 Final Thoughts and Future Work See omnystudio.com/listener for privacy information.

Send us a textThis week we're tackling a food we all know and love: flour. But is it really as harmless as it seems? Join me as I break down the surprising science of refined flour, cravings, and hormones—plus how a few small shifts can help you take back control of your weight loss journey.We'll talk about why flour is classified as an ultra-processed food, how it hijacks hunger signals, and why it can make weight loss feel harder than it should. Don't worry, I'll make it simple, light, and easy to understand—because this is about living your best life, not stressing over bread.Quote of the Week:“Your body is your home—feed it with care.” – Unknown Citations:Monteiro et al., 2019 – Ultra-processed foods: What they are and how to identify them. Public Health Nutrition.Hall et al., 2019 – Ultra-processed diets cause excess calorie intake and weight gain. Cell Metabolism.Ludwig, 2002 – The glycemic index: Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA.Friedman, 2014 – Leptin and the regulation of body weight. American Journal of Clinical Nutrition.Volkow et al., 2013 – The addictive dimensionality of obesity. Biological Psychiatry.Slavin, 2013 – Fiber and prebiotics: Mechanisms and health benefits. Nutrients.Hu, 2011 – Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care.ADA, 2020 – Standards of medical care in diabetes—2020. Diabetes Care.Let's go, let's get it done. Get more information at: http://projectweightloss.org

Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one's for you.Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.comSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Hettas: Use code FEISTY20 for 20% off at https://hettas.com/ Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% off This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy

In this conversation, Dr. Jason Sonners, a chiropractor and expert in hyperbaric medicine, shares his journey into the field of hyperbaric oxygen therapy (HBOT). He discusses the science behind HBOT, its mechanisms of action, and its applications in various health conditions, including cancer, brain health, and long COVID. Dr. Saunders emphasizes the importance of safety in hyperbaric therapy and the differences between soft and hard chambers. He also highlights the future of hyperbaric medicine and the growing awareness of its benefits.Chapters00:00 Introduction to Hyperbaric Medicine and Dr. Jason Sonners02:47 The Personal Journey to Hyperbaric Therapy05:50 Understanding Hyperbaric Oxygen Therapy (HBOT)09:09 Mechanisms of Healing: How HBOT Works11:48 The Role of HBOT in Cancer Treatment14:59 Comparing Soft and Hard Hyperbaric Chambers17:52 The Future of Hyperbaric Research and Applications27:00 The Science of Hyperbaric Therapy28:02 Creating Effective Protocols29:39 Combining Therapies for Optimal Results32:02 Understanding Telomeres and Aging33:10 Choosing the Right Hyperbaric Chamber39:11 Hyperbaric Therapy for Long COVID41:58 Addressing Brain Injuries and Cognitive Function45:28 The Future of Hyperbaric Medicine

In this episode, Erin and Autumn welcome Tim, a registered nurse, to discuss the dark side of nursing through the cases of Niels Högel and Charles Cullen, both male nurses who committed heinous crimes. The conversation explores the motivations behind their actions, the failures of hospital systems to protect patients, and the emotional toll on healthcare professionals. The hosts emphasize the importance of trust in healthcare and reflect on the need to appreciate the good nurses who work tirelessly to care for patients.Chapters00:00 Introduction and Guest Introduction02:36 Tim's Nursing Background and Role03:21 Exploring Cases of Male Nurses07:12 The Case of Niels Högel07:34 Understanding the Role of Nurses in Patient Care12:16 The Mechanisms of Medical Murder17:09 The Investigation and Arrest of Högel20:07 The Trial and Conviction of Niels Högel21:32 The Aftermath and Implications for Healthcare27:39 The Role of Nurses in Healthcare28:10 Introduction to Charles Cullen29:11 The Early Life of Charles Cullen31:09 The Start of a Nightmare32:58 The Pattern of Death35:29 The Arrest of Charles Cullen37:27 The Aftermath of Cullen's Crimes39:28 The Impact on Healthcare Practices42:11 The Importance of Trust in Nursing45:32 Conclusion and Reflection48:18 outro.wavKeywordsnursing, true crime, male nurses, medical murder, Niels Högel, Charles Cullen, healthcare, hospital safety, criminal cases, podcast

Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dynamic Aging Retreat Oct 3-5 2025This Episode's Show NotesJoin Our Newsletter: Movement Colored GlassesIn this episode, Katy Bowman and Jeannette Loram dive into the fascinating relationship between blood sugar, diet, and movement. They unpack how the body regulates blood sugar, what happens when this process breaks down in Type I and Type II diabetes, and why different kinds of activity play such a big role in prevention and management.Katy and Jeannette explain how contracting muscles can pull glucose directly into working cells during exercise—a powerful but site-specific effect—and how long-term training reshapes muscle to take up glucose more efficiently.They also compare the blood sugar benefits of endurance exercise, resistance training, HIIT, stretching, and even light daily movement. Along the way, they highlight two key scenarios: insulin resistance linked to excess weight and inflammation, versus insulin resistance driven by low muscle mass in people with normal weight. For the latter, they stress why resistance training—or “big body work”—is especially essential.CHAPTERS 0:06:00 - Definitions 0:16:00 - The Dynamic Collective 0:17:00 - You Can't Exercise Off Diabetes 0:20:00 - Muscle is the Key Tissue (and the Liver)0:36:30 - Stretching & Light Activity 0:47:00 - Exercise Modality for Blood Sugar Regulation0:54:25 - Listener Question on Lupus brought to you by Peluva 1:09:09 - Blood Sugar Spikes During Exercise BOOKS & RESEARCH PAPERS My Perfect Movement Plan by Katy BowmanI know I should Exercise, But... by Diana Hill & Katy BowmanExercise and GLUT4 by Flores-Opazo et al (2020) Mechanisms of endurance and resistance exercise in type 2 diabetes by Zhao et al (2025)  Sedentary behaviour as a mediator of type 2 diabetes by Hamilton et al (2015) Impact of reduced sitting time or increasing sit-to-stand transitions on blood pressure and glucose regulation in Postmenopausal women by Hartman et al (2025) The impact of standing desks on cardiometabolic and vascular health by Bodker et al (2021) MADE POSSIBLE BY OUR WONDERFUL SPONSORS:Sweet Skins, organic hemp and cotton clothing that is stylish, flexible and designed to move with you, take 20% off with code Movement20Peluva, Five-toe minimalist sports shoes ideal for walking and higher impact activities. Take 15% off with code NUTRITIOUSMOVEMENTIkaria Design, creators of the Soul Seat®, a height adjustable chair that allows you to sit in diverse shapes including cross-legged, take 10% of new inventory with code DNA10Venn Design, beautiful floor cushions and ball seats that keep you moving at home or at the officeEarth Runners, minimalist sandals that mimic being truly barefoot through their grounding technology, take 10% off with code DNA10Smart Playrooms, design and products to keep you and your kids engaged and active at home, take 10% off monkey bars, rock wall panels and holds with code DNA10

In this episode of Quah (Q & A), Sal, Adam & Justin answer four Pump Head questions drawn from last Sunday's Quah post on the @mindpumpmedia Instagram page.  Mind Pump Fit Tip: Ten Ways to Dramatically Improve Workout Consistency. (1:31) One of the EASIEST ways to bump protein and cut calories. (27:47) When you have kids, it's not about you and it's about them. (31:01) Make Orwell fiction again. (37:07) Diet is religion. (39:01) Exercise and depression. (42:01) Green Juice makes you feel good. (52:17) #Quah question #1 – I love your guys' programs. I do see people comment about how Arnold presses are a terrible movement. I do see you guys have them in your programming. How do you feel about the negative comments towards that exercise? (54:54) #Quah question #2 – What is the ideal mindset to have for people starting their health and fitness journey? (58:21) #Quah question #3 – What is something I can do during long rest periods? I want to avoid phones as much as I can, only tracking sets. (1:00:24) #Quah question #4 – I'm becoming a personal trainer, mostly because of you guys, and just landed my first client. What steps should I take from here? (1:06:47) Related Links/Products Mentioned Visit Butcher Box for this month's exclusive Mind Pump offer!  ** Available for a limited time, a curated box pre-filled with Mind Pump's favorite cuts — no guesswork! ButcherBox members who sign up through Mind Pump will receive: $20 OFF their first box, Free chicken breast, ground beef, OR salmon in every box for a whole year! ** Visit Organifi for the exclusive offer for Mind Pump listeners! **Promo code MINDPUMP at checkout for 20% off** July Special: MAPS Split or Anabolic Metabolism Bundle 50% off! ** Code JULY50 at checkout ** 6 Benefits of Walking After Meals, Backed by Health Experts Mind Pump #1522: How to Stay Consistent With Your Diet & Workout Mind Pump #2612: How One Man Lost Over 300 Pounds Without Any Cardio 7 Health Benefits of Pasture-Raised Chicken You Can't Ignore George Orwell's estate approves retelling ‘1984' from woman's point of view 1984: 75th Anniversary Mind Pump #2644: Eight Best Carbs for Bodybuilding & More (Listener Live Coaching) The Effects and Mechanisms of Exercise on the Treatment of Depression The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study Get your free Sample Pack with any “drink mix” purchase! Find your favorite LMNT flavor, or share it with a friend. Try LMNT risk-free. If you don't like it, give it away to a salty friend and we'll give you your money back, no questions asked! Visit DrinkLMNT.com/MindPump Mind Pump #1447: How to Start Your Fitness Journey Trainer Bonus Series Episode 1: The Successful Trainer Mindset Trainer Bonus Series Episode 2: Diet & Exercise Strategies That Work AND Clients Love Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Jamie Selzler (@jselzler) Instagram Paul Chek (@paul.chek) Instagram