Podcasts about mechanisms

4/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1918

3/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1916

1/8. Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul 1812.

2/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1917

Turn online alignment into an offline community — join us at TheWayFwrd.com to connect with like-minded people near you.Your symptoms aren't random, they're the crime scene of a moment your mind forgot.In this episode, I sit down with Dr. Melissa Sell to explore a biological map born from one doctor's grief, and how sudden emotional shocks, brain-level changes, and tissue adaptations follow a repeating pattern she now sees every day in people's scans and stories. I share two of my own stories – the rash that kept showing up on the right side of my face, and the colon scare that hit during one of the angriest seasons of my life – and how both matched this framework with borderline uncomfortable precision.If you've ever been told your symptoms are random, mysterious, or “just stress,” this conversation offers a very different lens.You'll Learn:[00:00:00] Introduction[00:08:22] Your symptoms are always telling the truth[00:11:04] Dr. Hamer's devastating loss, testicular cancer and the creation of the First Biological Law[00:18:55] What a real conflict shock is and why it's more than just being stressed out[00:25:11] The Five Biological Laws[01:06:29] The arrogance of not respecting, trusting and understanding nature's design[01:18:27] Why Ted Kaczynski's early separation trauma explains his later violent patterns[01:24:15] What happens when territorial anger and identity conflict strike at the same time[01:30:44] Brain layers, hormones, and hierarchy biology[01:44:49] How does our belief impact our physiology and symptoms?[02:02:15] Why doesn't everyone who experiences the same conflict develop symptoms?[02:23:13] Why seizures happen according to German New Medicine[02:37:22] Why do young babies get sick?[02:39:20] Can belief override or amplify the physical effects of harmful or beneficial substances?[02:46:22] Your body is infinitely adaptable, if you're relaxed[02:56:34] Is German New Medicine truly a universal biological law?[03:00:55] What to do when you can't figure out what the conflict was that is causing your symptoms[03:04:30] How to actually resolve your conflicts & why are there some conflicts you might not want to resolve?[03:09:26] When the healing phase would be too intense, surgery is still a good option[03:41:23] How your internal story shapes whether you lean into victimhood or transformation[03:43:29] Similarities between Traditional Chinese Medicine and German New Medicine[03:49:17] What allergies really are[03:59:01] Bringing conflicts into consciousness can offer immediate resolution[04:00:12] Detective work stories of deciphering conflicts and symptoms[04:12:52] Why forcing healing doesn't workResources Mentioned:The Way Forward episode on German New Medicine with Dr. Melissa Sell | Apple or SpotifyDr. Hamer | WebsiteGHK Self Study Bundle | WebsiteUse discount code TWF50 and save $50 off Melissa's course The Bio-Logical Woman starting February 2026.Find more from Dr. Melissa:Dr. Melissa Sell | WebsiteDr. Melissa Sell | YouTubeDr. Melissa Sell | FacebookDr. Melissa Sell | InstagramDr. Melissa Sell | XFind more from Alec:Alec Zeck | InstagramAlec Zeck | XThe Way Forward | InstagramThe Way Forward is Sponsored By:RMDY Academy & Collective: Homeopathy Made AccessibleHigh-quality remedies and training to support natural healing. Enroll hereExplore hereCreate a cleaner energetic space, go to AiresTech.com and use code TWF25 at checkout for 25% off your entire order.New Biology Clinic: Redefine Health from the Ground UpExperience tailored terrain-based health services with consults, livestreams, movement classes, and more. Visit www.NewBiologyClinic.com and use code TheWayForward for $50 off activation. The Way Forward members get the $150 fee waived

Today, I'm joined by the brilliant Dr. Elena Gross, a neuroscientist with an inspiring story and a relentless drive to solve the mysteries behind chronic migraines and brain health. Dr. Gross's personal journey—enduring twenty days of migraine each month and navigating countless failed treatments—led her from crawling through the pain to founding Brain Ritual, a company reimagining brain fuel for longevity.   Episode Timestamps: Intro and offers ... 00:00:00 Elena Gross's journey from chronic migraines to neuroscience ... 00:46 Distinguishing migraines from headaches ... 08:13 Energy deficit in the brain and ketones as a solution ... 15:05 Mechanisms and benefits of ketones for brain health ... 23:03 Micronutrients and mitochondrial support ... 28:20 Perfume, toxins, and migraine triggers ... 32:30 Hormonal, dietary, and oxidative stress factors in migraines ... 34:33 Exogenous ketones: Types, safety, and application ... 44:43 Brain Ritual supplement overview ... 47:04 Expanding beyond migraines: Mitochondria and neuropsychiatric health ... 57:31 Four pillars for mastering migraines ... 67:00 Actionable starting step for listeners ... 71:58 How to access Brain Ritual and community ... 73:10   Our Amazing Sponsors: Regenerive - Most cheap Ashwagandha is bulked up with stems and leaves to inflate the "actives." Those parts can bring compounds you don't actually want in your body. A root-only extract containing four newly identified bioactives, the ASHX4 Complex. Visit regenerive.co and use code NAT25 for 25% off.   StemRegen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   Blue Peptide Spray from Young Goose - brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Send us a textWe look at the emerging research linking ultramarathoning to a possible increased risk of colorectal cancer, particularly in individuals with inflammatory bowel disease (IBD). The discussion highlights the importance of hydration, nutrition, and recovery strategies for endurance athletes. Vitamin D and gut health also play an important role in decreasing risks. Takeaways-- Some research suggests that Ultramarathoning may increase the risk of colorectal cancer.- Hydration and nutrition are critical for endurance athletes.- Vitamin D levels should be regularly assessed, especially in athletes.- The gut microbiome can change with extreme endurance activities.- Recovery is essential for preventing long-term damage in athletes.- Training the gut to tolerate nutrition is important for performance.- Repeated extreme endurance events can lead to gut ischemia (lack of blood flow).- Nutrient deficiencies can exacerbate health risks in athletes with IBD.- A tailored approach to nutrition is necessary for athletes with IBD.- Understanding the mechanisms behind gut health can inform better training practices.Chapters:00:00- Introduction to Ultrarunning and Colon Cancer Risk02:37- Exploring the Connection Between Endurance and Colorectal Cancer05:17- The Role of Hydration and Nutrition in Endurance Sports08:07- Nutritional Considerations for Athletes with IBD10:48- The Importance of Vitamin D in Athletic Performance13:38- Understanding the Mechanisms of Gut Damage in Endurance Athletes16:23- The Impact of Recovery on Gut Health19:05- Conclusions and Recommendations for Athletes with IBDFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here.

Featuring an interview with Dr Erika Hamilton, including the following topics: General overview of the mechanisms of action of endocrine-targeted therapies for breast cancer (0:00) Downregulation of estrogen receptor expression levels with endocrine therapy; therapeutic benefit of selective estrogen receptor degraders (SERDs) and proteolysis-targeting chimeras (PROTACs) in ESR1 wild-type and ESR1-mutant breast cancer (5:11) Mechanisms of resistance to endocrine therapy (10:08) Efficacy and toxicities observed with SERDs and PROTACs for HR-positive breast cancer (15:26) Other applications for PROTACs (24:24) Emerging data from the Phase III evERA trial (27:38) Perspectives on clinical investigator and general medical oncologist practice pattern survey results (30:51) CME information and select publications

In this episode, I'm explaining what I believe is the most powerful tool we've ever had to slow and reverse the aging process.  We'll dive into the science behind why your body loses its regenerative fire as you age and how mesenchymal stem cells (MSCs), especially from young birth tissue, can reignite that healing intelligence from within.I've seen firsthand how inflammation silently drives disease and aging. Young mesenchymal stem cells have the ability to calm that Inflammaging fire and reawaken our body's natural healing systems.Let's talk about what's possible when we tap into the original code of life.Key TakeawaysIntroduction (00:00)Stem cell therapy and DNA intelligence (01:03)Inflammation and aging (07:07)Mechanisms of stem cell function (10:09)Comparison of young and old MSCs (21:56)Anti-aging benefits of stem cell therapy (31:34)Human studies and frailty (39:09)Anti-aging protocol and safety (41:57)Additional Resources:✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

Featuring a slide presentation and related discussion from Dr Erika Hamilton, including the following topics: Mechanisms of endocrine resistance; incidence of ESR1 mutations in breast cancer (0:00) Testing methods for ESR1 mutations in patients with breast cancer; therapeutic options for patients with ESR1-mutant breast cancer (3:59) General overview of proteolysis-targeting chimeras (PROTACs); comparison of PROTAC estrogen receptor (ER) degraders and selective ER degraders (7:39) Early-phase data with vepdegestrant monotherapy or in combination with CDK4/6 inhibitors in ER-positive, HER2-negative metastatic breast cancer (mBC) (11:54) Phase III VERITAC-2 trial of vepdegestrant versus fulvestrant in ER-positive, HER2-negative mBC previously treated with endocrine therapy and a CDK4/6 inhibitor (17:48) Ongoing clinical trials evaluating vepdegestrant in novel combinations or treatment settings; other clinical applications of PROTACs (26:08) CME information and select publications

Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826251344846

It's World AMR Awareness Week (WAAW) and we have prepared a special episode in light of that. In this week's Communicable, Navaneeth Narayanan and Thomas Tängdén host Aula Abbara (London, UK), Guido Granata (Rome, Italy) and Tuomas Aro (Helsinki, Finland) to discuss the phenomenon of AMR in conflict and crisis zones. They elaborate on how difficult conditions and austere environments amplify the spread of AMR, drawing on findings from the ongoing conflicts in Ukraine, Gaza, Syria and other regions. Other topics covered include adapting antimicrobial stewardship and infection prevention and control (IPC) practices as well as the need for genuine political will and international collaboration to end conflicts and their exacerbation on AMR.This episode follows the webinar “Beyond the frontlines” organised by ESCMID's AMR Action Subcommittee for WAAW 2025, featuring the same guests, and is available on ESCMID Media. This Communicable episode was peer reviewed by Arjana Zerja of Mother Theresa University Hospital Centre, Tirana, Albania.  Related ESCMID and Communicable mediaESCMID Media, Part 1: Beyond the frontlines - tackling AMR in conflict and crisis zones, webinar Communicable episode 11: Nightmare series, part 2 – how to deal with carbapenemase producers Communicable episode 16: Climate change and infections – effects on clinical practice & sustainabilityResourcesTrainee Association of ESCIMD (TAE) Doctors without Borders (Médecins sans Frontières), Antibiogo, https://www.antibiogo.org/Doctors without Borders (Médecins sans Frontières), Mini-lab, https://fondation.msf.fr/en/projects/mini-lab Further ReadingAbbara A, et al. Unravelling the linkages between conflict and antimicrobial resistance. NPJ Antimicrob Resist. 2025. DOI: 10.1038/s44259-025-00099-yAbbara A, et al. A summary and appraisal of existing evidence of antimicrobial resistance in the Syrian conflict. Int J Infect Dis. 2018. DOI: 10.1016/j.ijid.2018.06.010Abu-Shomar R, et al. Multidrug-resistant Pseudomonas isolated from water at primary health care centers in Gaza, Palestine: a cross-sectional study. IJID Reg. 2025. DOI: 10.1016/j.ijregi.2025.100671Aldbis A, et al. The lived experience of patients with conflict associated injuries whose wounds are affected by antimicrobial resistant organisms: a qualitative study from northwest Syria. Confl Health. 2023. DOI: 10.1186/s13031-023-00501-4Aro T, et al. War on antimicrobial resistance: high carriage rates of multidrug-resistant bacteria among war-injured Ukrainian refugees. Clin Microbiol Infect. 2025. DOI: 10.1016/j.cmi.2025.07.010  Bazzi W, et al. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front Microbiol. 2020. DOI: 10.3389/fmicb.2020.00068 Dewachi O. War Biology and Antimicrobial Resistance: The Case of Gaza, AMR Insights, 2024.Granata G, et al. The impact of armed conflict on the development and global spread of antibiotic resistance: a systematic review. Clin Microbiol Infect. 2024. DOI: 10.1016/j.cmi.2024.03.029 Huang XZ, et al. Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. Epidemiol Infect. 2012. DOI: 10.1017/S0950268811002871Hujer KM, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006. DOI: 10.1128/AAC.00778-06Karah N, et al. Teleclinical Microbiology: An Innovative Approach to Providing Web-Enabled Diagnostic Laboratory Services in Syria. Am J Clin Pathol. 2022. DOI: 10.1093/ajcp/aqab160Keen EF 3rd, et al. Evaluation of potential environmental contamination sources for the presence of multidrug-resistant bacteria linked to wound infections in combat casualties. Infect Control Hosp Epidemiol. 2012. DOI: 10.1086/667382Murray CK, et al. Recovery of multidrug-resistant bacteria from combat personnel evacuated from Iraq and Afghanistan at a single military treatment facility. Mil Med. 2009. DOI: 10.7205/milmed-d-03-8008Petersen K, et al. Diversity and clinical impact of Acinetobacter baumannii colonization and infection at a military medical center. J Clin Microbiol. 2011. DOI: 10.1128/JCM.00766-10Scott P, et al. An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. Clin Infect Dis. 2007. DOI: 10.1086/518170Sensenig RA, et al. Longitudinal characterization of Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonizing and infecting combat casualties. Am J Infect Control. 2012. DOI: 10.1016/j.ajic.2011.03.025World Health Organization. Fourth WHO Global Evidence Review on Health and Migration stresses that equitable access to and appropriate use of antibiotics for refugees and migrants is essential to tackling Antimicrobial Resistance, News, 2022.

Suleika Jaouad was diagnosed with cancer at 22. She made her illness the subject of a New York Times column and a memoir, Between Two Kingdoms. She and Steve talk about what it means to live with a potentially fatal illness, how to talk to people who've gone through a tragedy, and ways to encourage medical donations. SOURCES:Suleika Jaouad, author. RESOURCES:The Book of Alchemy: A Creative Practice for an Inspired Life, by Suleika Jaouad (2025).The Alchemy Journal, by Suleika Jaouad (2025).“The Art of Survival,” by Jennifer Senior (The Atlantic, 2024).American Symphony, film by Matthew Heineman (2023).Between Two Kingdoms: A Memoir of a Life Interrupted, by Suleika Jaouad (2021).“Max Ritvo, Poet Who Chronicled His Cancer Fight, Dies at 25,” by John Schwartz (The New York Times, 2016).“Life, Interrupted,” column by Suleika Jaouad (The New York Times, 2012-2015).The Fault in Our Stars, by John Green (2012).Bright-sided: How Positive Thinking Is Undermining America, by Barbara Ehrenreich (2009).The Isolation Journals, newsletter by Suleika Jaouad. EXTRAS:“John Green's Reluctant Rocket Ship Ride,” by People I (Mostly) Admire (2022).“Does Death Have to Be a Death Sentence?” by People I (Mostly) Admire (2022). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Medications such as Ozempic, Mounjaro and more have been popular in the media in recent years, but how can they affect menopause? In this episode, Adele unpacks the truth behind the buzz surrounding GLP-1 medications. Are they really miracle weight loss drugs for those in menopause? Nauck, M. A., Quast, D. R., Wefers, J., & Meier, J. J. (2021). GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art. Molecular Metabolism, 46, 101102. https://doi.org/10.1016/j.molmet.2020.101102   Holst, J. J., & Madsbad, S. (2016). Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor. Surgery for Obesity and Related Diseases, 12(6), 1236–1242. https://doi.org/10.1016/j.soard.2016.02.033 ____________ Check out Adele's FREE symptom assessment here: https://adelejohnstoncoaching.com/free-copy-of-our-symptom-assessment/ 12 Minute Breathwork Method: https://adelejohnstoncoaching.com/breathwork/ The Menopause Cheat Sheet: https://docs.google.com/document/d/1ka-fN6J5DJW2J3IE0Qa80zFCKFXmTs4srlnlXYBf-gA/edit?usp=sharing If you want a chat for your future success, fuel yourself here: https://calendly.com/adelejohnston/successchat Download Adele's Journey Journal here : https://adelejohnstoncoaching.com/my-journey-journal/ Enquire about 121 coaching here : https://docs.google.com/forms/d/e/1FAIpQLSfw6vrmKPE7A1eYDKQJiR9No7ZDdpfq-grBdKYjZSR-vl0Qag/viewform For extra support: Support@adelejohnstoncoaching.com ____________ From your host : Adele Johnston I'm Adele Johnston, a certified nutritionist and positive psychology coach, passionate about helping women improve their menopause health and reclaim who you are without menopause taking over. This is a time in your life where you get to feel vibrant, sexy and reclaim you again! I'm proud to work with women like you and have created a very successful proven Reclaiming You 3 STEP PROCESS to help you take back control of your body during your menopause. For more details : https://adelejohnstoncoaching.com/ To get Adele's FREE 3-step Menopause Weight Loss Guide: https://adelejohnstoncoaching.com/menopause-weight-loss-guide/

Send us a text On October 26, 2025, the Rapid Support Forces seized Al-Fashir, the last government-held city in Darfur. What followed was one of the deadliest massacres of Sudan's brutal civil war. Over 460 patients and companions were killed at the Saudi Maternity Hospital on October 28th alone, with total death tolls exceeding 2,500 people. In this episode, we uncover the horrifying reality of the RSF's systematic violence in Darfur, examine the international community's silence, and explore what accountability looks like when war crimes unfold in real time. Our guest for today is Dr. Abdulla Hafeez and Khadega Mohamed.  This is a story the world needs to hear.  WHAT YOU'LL LEARN: • The October 26-28 Al-Fashir massacre timeline and verified death tolls • Who the Rapid Support Forces are and how they gained power in Sudan • The strategic importance of Al-Fashir as Darfur's last government stronghold • Evidence of systematic attacks on hospitals and medical infrastructure • The role of external actors, particularly UAE support for RSF operations • Why this crisis receives minimal international media coverage • The humanitarian catastrophe facing 12 million displaced Sudanese civilians • Mechanisms for documenting war crimes and pursuing justice • Potential scenarios for ending the violence in Darfur and broader Sudan You can donate here:   https://sapa-usa.org/el-fasher-emergency-response/  https://sapa-usa.org/?gad_source=1&gad_campaignid=22771252936&gbraid=0AAAAA-5PS-mE0vzyYCK1teCA7XYxUkEpP  Subscribe for more investigative journalism covering the stories mainstream media ignores. Share this episode to raise awareness about Sudan's ongoing humanitarian catastrophe. Visit Ozmedia313.com for more in-depth coverage.Follow us on social media:- Instagram: @motivateme313 or @ozmedia313- Website: ozmedia313.com- Facebook: ozmedia313-TikTok: @ozmedia313-Apple Podcast: ozmedia-Spotify Podcast: ozmediaThis show was sponsored by:-The Family Doc https://thefamilydocmi.com/-Juice Box Juiceboxblend.com-Holy Bowly http://www.myholybowly.com-Wingfellas thewingfellas.com-Hanley International Academy https://www.hanleyacademy.com-Malek Al-Kabob malekalkabob.com-Bayt Al Mocha https://baytalmocha.com/-Chill Box https://www.chillboxstore.com/-Royal Kabob https://www.royalkabob.com/-GEE Preparatory Academy https://www.gee-edu.com/schools/geepreparatory/index#SudanWar #DarfurConflict #SudanCivilWar #AfricaNews #LatestNews #WorldNews 

Ultra-processed foods have become central to the way we eat and to many of the challenges we face in public health nutrition. They dominate supermarket shelves, shape population diets, and often appear as the prime suspect in rising obesity and metabolic disease rates. But beyond the label itself, what exactly makes these foods problematic? Is it their nutrient composition, their texture and palatability, the rate at which we consume them, or the broader environments that make them so accessible and appealing? The debate around ultra-processed foods sits at the intersection of metabolic science, behaviour, and policy. It raises uncomfortable questions about how food systems evolved to prioritise convenience and profit, and what it might take to meaningfully change that trajectory. In this episode, Dr. Kevin Hall joins the podcast to examine the evidence from controlled feeding studies and population research, exploring what we really know about ultra-processed foods, overeating, and how we might begin to fix the food environment. Timestamps [04:24] Dr. Hall's background and career [06:47] Ultra processed foods and health [15:10] Mechanisms behind ultra processed foods [27:00] Healthy ultra processed foods: a possibility? [30:43] Minimizing ultra processed foods in different cultures [33:03] Policy and regulation for better food quality [44:26] The importance of pilot studies in policy implementation [49:10] Future of food and sustainable diets [51:50] Key ideas segment (Premium-only) Links & Resources Go to episode page (with links to studies) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course X: @KevinH_PhD @NutritionDanny Book: Food Intelligence: The Science of How Food Both Nourishes and Harms Us Previous episodes with Dr. Hall: #429, 376, 165, 88

Send us a textThis week we are talking about our life lines. I ask you to consider — who's your lifeline?Not the metaphorical one, but the real, human connection that keeps you afloat when life gets heavy.We'll dig into the interesting history of the word “lifeline,” what research says about how connection affects our health and habits, and how you can create your own H-Factor system of support.It's practical and deeply human —you'll leave reminded that you were never meant to do this alone. Quote of the week“My humanity is bound up in yours, for we can only be human together. When we see the other as part of ourselves, we begin to build a world where no one is left behind.”by Desmond TutuInstagram: fina.projectweightlossCitationsEtymonline. (2024). Lifeline – Origin & Definition. Retrieved from etymonline.comUchino, B. N. (2020). Social support and health: A review of physiological processes potentially underlying links to disease outcomes. National Center for Biotechnology Information (NCBI).Lakey, B., & Orehek, E. (2022). Perceived social support and mental health: A review of recent findings.Frontiers in Psychology.Maher, C. A. et al. (2020). Social support and weight-loss interventions: Mechanisms of behavior change.Frontiers in Psychology.Let's go, let's get it done. Get more information at: http://projectweightloss.org

Mentor Sessions Ep. 037: Michael Morelli on Rock Bottom Addiction Recovery, Building a Bitcoin-Powered Fitness Empire, Parallels to Sound Money & Radical LongevityMichael Morelli's Bitcoin journey mirrors his brutal addiction recovery: from high more than sober for a decade, snorting oxycodone amid bankruptcy and affairs, to a 113-day shred from 25% to 8% body fat—bootstrapping FitScript into a multimillion-dollar data-driven health empire coaching 600+ men with peak biomarkers while stacking BTC as a maxi since 2020. Inspired by Saifedean Ammous' "The Bitcoin Standard," Morelli draws logical parallels between paleo nutrition's ancestral simplicity and Bitcoin's finite, sound money—why it's the only asset that "just seems logical" in a fiat-fueled health and wealth disparity crisis. In this BTC Sessions interview, he busts carnivore myths (labs "fucking wrecked"), unpacks peptides for faster gains, red light therapy hacks, and his no-excuses mantra: if a coke-addicted bankrupt can rebuild to live until 150, stacking sats with low-time preference, Bitcoiners have zero excuses for subpar health. Topics:Brutal rock bottom: Addiction, abuse & what led there113-day rebirth: Fatherhood spark & no-excuses mindsetBootstrapping empire: Mom's basement to millionsFitness myths busted: Carnivore dangers & paleo logicBitcoin awakening: Shitcoins to maxi via SaifedeanHealth-money parallels: Disparity extremes & white coat trapsActionable optimization: Low-hanging fruit for BTC stackersPeptides decoded: Mechanisms for faster recoveryRed light therapy: Mitochondria boost & hair regrowthEntrepreneurship grit: Fuck Aging brand & mindset masteryChapters:00:00 Teaser & Intro01:24 Background & Journey02:09 Addiction & Rock Bottom04:42 No Excuses06:10 Abuse & Roots13:04 Fitness & Control16:34 Empire Collapse19:03 Biz Success23:42 Myths & Paleo26:13 Lab & FitScript31:05 BTC Parallels & Journey33:06 Disparities & Pharma38:50 Actionable Tips43:07 Longevity & Alpha47:53 Peptides & Red Light1:02:45 Outro & DiscountAbout Michael MorelliPerformance health engineer, founder FitScript. Test, don't guess. X.com: @morellifitFitScript: fitscript.me (mention podcast for $1000 off)Check previous ep with Prince Filip of Serbia: https://youtu.be/h7kyNNUuLOg

Cracked teeth — the diagnosis we all hate as Dentists! How do you decide when to monitor and when to intervene? What is the recommended intervention at different scenarios of cracks? Should we be chasing cracks and reinforcing with fibers; is there actually enough long-term data to support that approach? Over the years, we've had some epic episodes on this topic — from Kreena Patel's “I Hate Cracked Teeth” (PDP028) to Dr. Lane Ochi's Masterclass on Diagnosis and Management (PDP175). But in this brand-new episode, Jaz is joined by Dr. Masoud Hassanzadeh to bring it all together — not just the diagnosis of cracks, but their management. They explore when to intervene, the role of fibers in preventing propagation, and even the fascinating possibility that cracks in teeth may have some ability to heal, just like bone! This one's a deep dive that will change how you talk to patients — and how you approach cracked teeth in your own practice. https://youtu.be/VHYRBnfJS3I Watch PDP246 on YouTube  Protrusive Dental Pearl Your patient's history predicts the future! Ask if past extractions were difficult → clues you into anatomical challenges. Ask how they lost other teeth → if cracks, be proactive with today's cracks. History isn't just background—it's a clinical tool. Key Takeaways Cracks in teeth can be diagnosed using magnification and high-quality imaging. Patient factors such as age and muscle strength play a significant role in crack prognosis. Symptomatic cracks should be treated to prevent further propagation. Understanding the anatomy of the tooth is crucial for effective treatment. The healing mechanism of cracks in teeth is possible but varies between enamel and dentin. Fibers can be used to strengthen restorations and manage cracks effectively. Long-term studies are needed to assess the effectiveness of current crack management protocols. The use of fluorescence filters can help identify bacteria in cracks. Chasing cracks should be done cautiously to avoid pulp exposure. A comprehensive understanding of crack mechanics can improve treatment outcomes. Highlights of this episode: 00:00 Teaser 00:47 Intro 03:08 Protrusive Dental Pearl - The Importance of Dental History 07:18 Interview with Masoud Hassanzadeh 08:22 Diagnosing and Managing Cracks 21:13 When to Intervene on Cracks 25:50 Restoration Techniques and Materials 28:30 Chasing Cracks: Guidelines and Techniques 36:50 Mechanisms of Crack Healing in Teeth 45:11 Exploring the Use of Fibers in Dentistry 52:43 Introducing the Book on Cracked Teeth 54:57 Percussion-Based Diagnostics (QPD) 56:44 Key Takeaways 57:21 Conclusion and Final Thoughts 01:00:07 Outro As promised, here are the studies mentioned during the discussion: Why cracks do not propagate as quickly in root dentin: Study 1a & 1b Root dentin has significantly higher fracture toughness compared to coronal dentin—nearly twice as tough, as demonstrated in multiple studies. The key difference lies in their structure and toughness. Root dentin's unique collagen orientation adds strength, while its fewer lumens and thinner peritubular cuffs make it less brittle. In contrast, coronal dentin has thicker cuffs, which increase brittleness. Unlike coronal dentin, which fractures uniformly, radicular dentin is anisotropic—its fracture behavior varies depending on direction. These structural features give root dentin greater resistance to cracking, making it more durable under stress. Studies on decreasing crack length due to crack repair in enamel. Study 2 The importance of the modulus of elasticity of the final restoration in arresting crack propagation. Study 3 The role of fiber in restoring cracked teeth and how it can increase fracture strength—even surpassing that of natural teeth. Study 4 Decision Making for Retention of Endodontically Treated Posterior Cracked Te...

In this episode of the Flex Diet Podcast, I sit down with my good friend Dr. Dan Pardi for a deep dive into all things health, longevity, and cognitive performance. We get into the science of stem cells and aging, the real benefits (and limits) of popular supplements, and how nootropics like Ritalin and Modafinil actually work—or don't—in the real world.We also talk about how to integrate training and movement into insanely busy lives, the psychology of health behavior, and why being flexible in your approach (not just in your hamstrings) is key to long-term success.This episode is brought to you by Quaia Life, where Dan's doing some fascinating work on cutting-edge supplements designed to optimize health and performance. They're offering listeners 15% off their products, which you can grab through the link in the show notes.If you want a mix of actionable tips, science-backed insights, and a peek behind the curtain of how top researchers think about performance and aging, you'll definitely want to tune in.Sponsors:Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8Qualia: https://qualialife.com/drmike15Coupon Code: DRMIKE15 (listeners get an additional 15% off any Qualia order)Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:01:51 Science Communication and Cognitive Performance02:43 Sponsorship and Product Endorsement04:54 The Importance of Flexibility in Training06:39 Integrative and Opportunistic Training15:50 The Psychology of Health and Performance24:12 Quality of Life and Nootropics31:12 Understanding Cognitive Enhancement44:30 Modafinil and Its Effects50:50 Exploring the Benefits and Downsides of a New Drug51:22 Mechanisms and Effects of the Drug52:42 Hallmarks of Aging and Their Impact58:07 Understanding Stem Cells and Their Functions01:01:52 Formulating a Stem Cell Supplement01:10:18 Sequencing Protocols for Optimal Health01:15:13 Challenges and Research in the Supplement Industry01:23:33 Final Thoughts and Recommendations01:34:29 Podcast Conclusion and Disclaimers Flex Diet Podcasts You May Enjoy: Episode 263: Lifestyle, Longevity, and the Future of GLP-1 Agonist Use in Wellness with Christa RymalYouTube: https://youtu.be/SlALIb74KvMEpisode 165: Health, Sports Performance and Longevity Medicine: Dr Rick Cohen with Dr. Mike T NelsonYouTube: https://youtu.be/bYk_wzBJzJYConnect with Dr Pardi:Qualia: https://www.qualialife.com/Instagram: https://www.instagram.com/dan_pardiGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

"Send me a text"In this episode, discover how to boost your supplement marketing success during Black Friday and Cyber Monday by mastering high-converting mechanisms tailored for fast-moving buyers. Discover how to compress your unique selling mechanism without losing its persuasive impact to drive e-commerce growth and stand out from competitors.Learn the two-part mechanism framework (trust + hope)How to ground your messaging in logic instead of hypeWhich ingredients to spotlightThe three-sentence mechanism formula that converts deal-hunters into believersAnd more... Stop treating your supplement like a commodity and start giving buyers clear reasons to choose your brand over dozens of competitors, even in the crowded discount environment. This episode is essential for supplement marketers aiming to maximize e-commerce growth this holiday season.If you're interested in working with me and my team to improve your supplement business. You can learn more at my website https://creativethirst.com Click here to grab your copy of the Health Supplement Ad Swipe Guide. Discover what really works in funnel marketing Need help increasing sales on your own? Click here Stuck at $1 - $5M in revenue? Click Here Case Study on how Creative Thirst added over $200,000 for one supplement brand

In this episode of the Epigenetics Podcast, we talked with Vincent Pasque from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. We begin by tracing Vincent's journey into biology, sparked by early childhood experiences in nature and meaningful encounters with inspiring teachers. His fascination with the complexities of biology crystallized during a pivotal moment while listening to a radio segment on epigenetics in the late '90s, which led him to pursue studies in genetics and biochemistry. This formative path brought him to leading institutions, including the prestigious lab of John Gurdon, where he explored the phenomenon of nuclear reprogramming. Vincent recounts his early experiments that led to the discovery of macro H2A as a barrier to reprogramming, emphasizing the core challenge of erasing somatic cell identity. As the conversation unfolds, Vincent introduces us to critical findings from his research. He shares how the inactive X chromosome serves as a compelling model to investigate epigenetic regulation, revealing that the dynamics of reprogramming and differentiation are far from simple reversals of development. He highlights the significant differences between male and female iPSCs and how X-linked genes influence DNA methylation and differentiation rates in these cells. The implications of these findings extend beyond developmental biology to inform our understanding of diseases, particularly cancer. Transitioning to his current work, Vincent describes pioneering advances in characterizing the chromatin-associated proteome during the differentiation of human pluripotent stem cells. The surprising discovery of elevated histone modifications in naïve cells leads to intriguing questions about the barriers to cellular plasticity and the mechanisms by which cells resist alternative fate conversions. The potential applications of this research could reshape our approach to regenerative medicine and therapeutic interventions. References Pasque V, Gillich A, Garrett N, Gurdon JB. Histone variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal. 2011 May;30(12):2373-2387. DOI: 10.1038/emboj.2011.144. PMID: 21552206; PMCID: PMC3116279. Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C. R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi, K., & Gurdon, J. B. (2014). Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming. Molecular Cell, 55(4), 524–536. https://doi.org/10.1016/j.molcel.2014.06.024 Pasque V, Tchieu J, Karnik R, et al. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014 Dec;159(7):1681-1697. DOI: 10.1016/j.cell.2014.11.040. PMID: 25525883; PMCID: PMC4282187. Zijlmans DW, Talon I, Verhelst S, et al. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology. 2022 Jun;24(6):858-871. DOI: 10.1038/s41556-022-00932-w. PMID: 35697783; PMCID: PMC9203278. Related Episodes The Discovery of Genomic Imprinting (Azim Surani) Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle) Epigenetics and X-Inactivation (Edith Heard) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this episode, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, dives deep into estrone, one of the three key estrogens, and explains why understanding it is crucial for women's health. Learn about: The differences between estradiol, estriol, and estrone How estrone levels shift during perimenopause and menopause Why oral estrogen can dramatically increase estrone The impact of lifestyle factors like diet, body fat, stress, alcohol, and sedentary behavior on estrogen balance Practical tips to support healthy estrogen metabolism naturally Dr. McCarthy breaks down complex biochemistry in a clear, actionable way so you can take charge of your hormonal health.   Citations: 1. Bulun, Serdar E., et al. “Aromatase and Estrogen Biosynthesis in Adipose Tissue.” Endocrine Reviews, vol. 23, no. 3, 2002, pp. 305–342. 2. Labrie, Fernand, et al. “Importance of the Intracrinology of Estrogen Synthesis in Peripheral Tissues in Postmenopausal Women.” Journal of Steroid Biochemistry and Molecular Biology, vol. 118, nos. 4–5, 2010, pp. 273–279. 3. Sasano, Hironobu, and Toshihiko Harada. “Differential Expression of Aromatase and 17β-Hydroxysteroid Dehydrogenase Isoenzymes in Human Tissues.” Journal of Steroid Biochemistry and Molecular Biology, vol. 86, no. 3–5, 2003, pp. 327–333. 4. Yager, James D., and Nancy E. Davidson. “Estrogen Carcinogenesis in Breast Cancer.” New England Journal of Medicine, vol. 354, no. 3, 2006, pp. 270–282. 5. Cavalieri, Ercole L., and Eleanor G. Rogan. “Depurinating Estrogen-DNA Adducts, Mechanisms of Formation, and Prevention.” Clinical Cancer Research, vol. 16, no. 3, 2010, pp. 596–602. 6. Suba, Zsuzsanna. “Circulating Estrogens and Estrogen Metabolism in Obese Women.” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 11, 2013, pp. 4336–4344. 7. Simpson, Evan R., and Konstanze C. Pike. “Aromatase Expression in Adipose Tissue: Relationship to Obesity and Insulin Resistance.” Endocrinology, vol. 156, no. 9, 2015, pp. 3422–3435. 8. Key, Timothy J., et al. “Circulating Sex Hormones and Breast Cancer Risk Factors in Postmenopausal Women: Reanalysis of 13 Studies.” British Journal of Cancer, vol. 105, no. 5, 2011, pp. 709–722. 9. Stanczyk, Frank Z., et al. “Oral, Transdermal and Injectable Hormone Therapy: Pharmacokinetics and Effects on Estrone/Estradiol Ratios.” Menopause, vol. 24, no. 9, 2017, pp. 1080–1090. 10. Santen, Richard J., et al. “Estrogen Bioidentical Hormone Therapy: Route of Administration and Risk.” Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 7, 2020, pp. 2062–2074. 11. Zeleniuch-Jacquotte, Anne, et al. “Postmenopausal Levels of Estrone, Estradiol, and Estrone Sulfate and Breast Cancer Risk.” Cancer Epidemiology, Biomarkers & Prevention, vol. 23, no. 8, 2014, pp. 1531–1539. 12. Dall, Gabriella V., and Christine L. Clarke. “Local Estrogen Biosynthesis and Signaling in Breast Cancer Progression.” Steroids, vol. 78, no. 7, 2013, pp. 639–646. 13. Heald, Anthony H., et al. “Relationships Between Serum Estrone, Insulin Resistance, and Adiposity in Postmenopausal Women.” Clinical Endocrinology, vol. 67, no. 3, 2007, pp. 340–345. 14. Kuiper, George G. J. M., et al. “Estrogen Receptor β Selectivity of Estriol and Implications for Tissue-Specific Effects.” PNAS, vol. 94, no. 17, 1997, pp. 9105–9110. 15. Michnovicz, Joseph J., et al. “Dietary Indoles and Estrogen Metabolism: Effects of Cruciferous Vegetable Intake.” Journal of Nutrition, vol. 134, no. 12, 2004, pp. 3479S–   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Send Vanessa a Text MessageNEW WEBSITE: https://intentionallywellpodcast.com/In this episode, I sit down with William Parker, PhD, a scientist with decades of research in biochemistry, microbiology, and immunology. Best known for discovering the function of the human appendix and as a leading researcher studying acetaminophen (Tylenol) and its impact on neurodevelopment, William shares his insights on a topic that has recently garnered widespread media attention and public discussion, sparking conversation around acetaminophen and autism risk.We explore:How acetaminophen interacts with the body during critical periods of developmentThe biological pathways connecting acetaminophen exposure to neurodevelopmental outcomesWhy this research matters to parents, caregivers, and anyone invested in child healthCommon questions, concerns, and rebuttals surrounding acetaminophen and autism riskThe gaps in pediatric education and medical literature that often leave these risks under-discussedThis episode is designed to break down complex science in a way that is understandable, actionable, and presented through a compassionate and logical lens. Whether you're a parent, healthcare professional, or just curious, you'll walk away with a clearer understanding of the evidence, the controversies, and the implications for children's health today.For those who'd like to explore Dr. Parker's research and related literature, here are the studies and resources mentioned in this episode:Acetaminophen and Autism: Evidence from a Systematic Review (MDPI, 2024)Mechanisms of Acetaminophen-Induced Neurodevelopmental Effects (MDPI, 2024)Preprint: Revisiting Acetaminophen and Autism—A Global Call for Reevaluation (2025)Preprint: Acetaminophen, Oxidative Stress, and Neurodevelopmental Risk (2025)Prevent Autism—Educational and Research ResourceEvidence That Acetaminophen Triggers Autism in Susceptible Individuals Has Been Ignored and Mishandled for More Than a Decade (RealClear Public Health, 2025)Connect with the show:Podcast on InstagramVanessa on InstagramPodcast on YouTubePodcast on TikTokPodcast on XEmail: intentionallywellpodcast@gmail.comSupport the ShowIf this podcast has encouraged you and you'd like to help me continue sharing impactful content, you can support the show here:Support the Show© 2025 Vanessa Lopez, Intentionally Well Podcast. All rights reserved. No part of this podcast or show notes may be copied, shared, oSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

Why does it work? Proposed biomedical effect mechanisms of exercise-based injury prevention programmes in football (Soccer) and handball: a scoping review of 104 studies Moen C, Myklebust G, Munkvold E, et al. Br J Sports Med. 2025;59(20):1435-1442. doi:10.1136/bjsports-2025-109802 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest VALD MoveHealth - https://movehealth.me/ Learn more about/Buy Erik/Jason/Chris's courses – The Science PT Support us on the Patreons! Music for PT Inquest: "The Science of Selling Yourself Short" by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux

Creatine's story has been far too small for its biology. Most people still see it as a supplement for strength or cognitive performance, but its most important work happens inside the mitochondria.In this episode, we explore a side of creatine few people talk about: how it may function as mitochondrial medicine. We'll break down 3 distinct ways creatine acts in and supports the mitochondria; roles that could reshape how we think about energy, resilience, and cellular health.  And beyond that, how creatine may be one of the few molecules that can both diagnose and treat mitochondrial dysfunction. 00:00 Understanding Mitochondrial Dysfunction00:43 Introduction to Creatine's Role01:16 Mitochondrial Dysfunction Explained01:56 Creatine as a Theranostic Agent02:57 Mechanisms of Creatine in Mitochondria04:09 Therapeutic Roles of Creatine05:22 Redox Control and Antioxidant Properties06:27 Conclusion: The Unique Power of Creatine PMID: 40948982

Send us a textEver wonder why some moments with your child feel effortless and deeply connected — while others leave you drained, reactive, or misunderstood? In this episode, we break down the science behind why.Dr. Jessie Stern and psychologist Rachel Samson join Cindy to explore relational savoring — a simple yet powerful way to strengthen your bond by intentionally remembering moments of warmth, safety, and love. You'll learn how this practice calms your nervous system, reduces stress, and builds emotional security — for both you and your child.They also unpack the role of temperament and sensitivity in relationships. Why do some people (and kids) feel everything more deeply? What does that mean for how we connect, comfort, and communicate?If you've ever said, “I wish I could stay calm when things get hard,” this conversation will give you the science and the self-awareness to start doing exactly that.Because connection isn't about perfection — it's about noticing, savoring, and showing up with compassion.Read their new book: Beyond Difficult: An attachment-based guide to dealing with challenging peopleFollow Rachel SamsonFollow Dr. Jessie SternRead the science article: Savoring interventions for mothers of young children: Mechanisms linking relational savoring and personal savoring to reflective functioningListen to more podcast episodes:https://podcasts.apple.com/ca/podcast/reflective-parenting-by-curious-neuron/id1440533170?i=1000731541535Support the showJoin our Reflective Parenting Program to learn the science-based skills parents (and their kids) need to thrive: https://curiousneuron.com/reflective-parent-club/ Record your question, or share a parenting insight in a 1 min audio we will share on the podcast https://www.speakpipe.com/ReflectiveParentingPodcast Book a spot in my calendar to chat about your challenges: https://calendly.com/curious_neuron/chat-with-cindy-reflective-parent-club-clone Grab a Free Resource: FREE Workbook: Staying Calm When Your Child Isn't: A Parent's Guide to Triggers and Emotions Email: info@curiousneuron.com

What if the key to solving the mysteries of modern physics lies not in new mathematics, but in a physical interpretation of the mathematics we already have?This week, we begin a deep, two-part conversation with Dr. Chantal Roth about the Elastic Aether Theory—one of the first serious contenders we've found for a material interpretation of fundamental physics. Dr. Roth's quest for a deeper understanding of the universe begins by taking the mathematics of General Relativity, applying a set of material science axioms, and deriving what the mathematics of light and gravity tell us about the physical properties of the universe. Check out part 2, where we dive into the ether-based mechanisms for mass, light, charge, electricity, and gravity. PATREON https://www.patreon.com/c/demystifysciPARADIGM DRIFThttps://demystifysci.com/paradigm-drift-showHOMEBREW MUSIC - Check out our new album!Hard Copies (Vinyl): FREE SHIPPING https://demystifysci-shop.fourthwall.com/products/vinyl-lp-secretary-of-nature-everything-is-so-good-hereStreaming:https://secretaryofnature.bandcamp.com/album/everything-is-so-good-here00:00:00 Go!00:01:05 Introduction to Quantum Mechanics and Elastic Aether Theory00:05:24 The Quest for Understanding in Quantum Physics00:10:12 Perspectives on Aether and Spacetime00:15:57 Properties of Space: Elastic Solid Analogy00:20:48 Newton's Vision of Aether as a Mediator00:21:53 Newton's Ideas on Gravity and Refraction00:24:11 Mechanisms of Refraction and Light Behavior00:28:11 Limitations of Analogies in Wave Behavior00:33:58 Historical Context and Physics Connections00:37:26 The Concept of Metric Tensor in Space00:41:21 Discussion on the Constancy of Light Speed00:45:04 Mechanical Explanation of Wave Speed00:50:12 Interconnectedness and the Nature of Matter00:55:56 Refractive Index and Its Role in Gravity00:59:50 Examination of Atom Composition and Aether01:01:52 Introduction to Waves and Ether01:05:00 Wave Patterns and Their Implications01:09:00 Density and Stiffness in the Aether01:13:00 The Nature of Light Near Massive Objects#quantummechanics , #ElasticEtherTheory, #modernphysics , #physicsexplained , #theoreticalphysics , #historyofscience , #alberteinstein , #isaacnewton , #spacetime , #generalrelativity , #quantumphysics , #waveparticleduality , #cosmology , #light , #mindscape , #stringtheory , #mechanics MERCH: Rock some DemystifySci gear : https://demystifysci-shop.fourthwall.com/AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98DONATE: https://bit.ly/3wkPqaDSUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci RSS: https://anchor.fm/s/2be66934/podcast/rssMAILING LIST: https://bit.ly/3v3kz2S SOCIAL: - Discord: https://discord.gg/MJzKT8CQub- Facebook: https://www.facebook.com/groups/DemystifySci- Instagram: https://www.instagram.com/DemystifySci/- Twitter: https://twitter.com/DemystifySciMUSIC: -Shilo Delay: https://g.co/kgs/oty671

Dietitians Torwen Eerkens discuss the impact of carbohydrates on sleep quality, exploring various mechanisms, the timing and type of carbohydrates, and practical recommendations for incorporating carbs into the evening routine.  (00:27) - Mechanisms and Research Background (02:14) - High GI vs Low GI Carbohydrates (6:00) - Carbohydrate Quantity  (6:48) - Potential Downsides to Adding Carbs Before Bed  (8:55) - Practical Recommendations  (10:23) - Tart Cherry Juice WEBSITE:  https://www.idealnutrition.com.au/ PODCAST:  https://www.idealnutrition.com.au/podcast/ INSTAGRAM:  https://www.instagram.com/idealnutrition__/?hl=en Our dietitians

In this week's episode of the Blood Podcast, Associate Editor Dr. James Griffin interviews Drs. Binod Dhakal and Ruben Bierings about their respective papers published in this week's issue of Blood. Dr. Dhakal presents his study on using talquetamab, a bispecific antibody, as a bridging therapy before BCMA-targeted CAR T-cell therapy in multiple myeloma patients, showing promising results with high response rates and manageable toxicities. Next, Dr. Bierings identified patients with genetic variants in the guanine exchange factor MAP kinase–activating death domain (MADD) that impair VWF secretion from endothelial cells and possibly cause VWD type 1. Featured ArticlesA novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variantsSophie Hordijk, Stijn A. Groten, Petra E. Bürgisser, Sebastiaan N. J. Laan, Georg Christoph Korenke, Tomáš Honzík, Diane Beysen, Frank W. G. Leebeek, Paul A. Skehel, Maartje van den Biggelaar, Tom Carter, Ruben BieringsSequential targeting in multiple myeloma: talquetamab, a GPRC5D bispecific antibody, as a bridge to BCMA CAR-T therapyBinod Dhakal, Othman S. Akhtar, David Fandrei, Alexandria Jensen, Rahul Banerjee, Darren Pan, Shambavi Richard, Reed Friend, Matthew Rees, Patrick Costello, Mariola Vazquez Martinez, Oren Pasvolsky, Charlotte Wagner, James A. Davis, Omar Castaneda Puglianini, Ran Reshef, Aimaz Afrough, Danai Dima, Manisha Bhutani, Omar Nadeem, Ricardo Parrondo, Ciara Freeman, Lekha Mikkilineni, Shahzad Raza, Larry D. Anderson Jr, Prashant Kapoor, Hitomi Hosoya, Saurabh Chhabra, Ariel Grajales-Cruz, Mahmoud Gaballa, Shonali Midha, Melissa Alsina, Douglas Sborov, Krina Patel, Yi Lin, Christopher Ferreri, Nico Gagelmann, Anupama Kumar, Doris Hansen, Andrew Cowan, Luciano J. Costa, Maximilian Merz, Surbhi Sidana

Send us a textIn this episode of PT Snacks podcast, we continue our discussion on the sacroiliac (SI) joint, discussing optimal manual techniques and exercises to help patients experiencing SI joint pain. We'll break down the function of the SI joint, explore the latest research on manual therapy, and explain why a combination of manual therapy and exercise is most effective. Join us as we cover high-level reviews and specific techniques to help your patients move better and feel better. Don't forget to hit the subscribe button, leave a review, and check out the special MedBridge discount in the show notes!00:00 Introduction and Podcast Overview00:26 Listener Feedback and Today's Topic Introduction01:29 Understanding the Sacroiliac (SI) Joint02:03 Manual Therapy Techniques for SI Joint05:52 Mechanisms and Theories Behind Manual Therapy13:46 Exercises for SI Joint Stabilization15:44 Combining Manual Therapy and Exercise16:57 Conclusion and Additional ResourcesTrager RJ, Baumann A, Rogers H, et al. Efficacy of manual therapy for sacroiliac joint pain syndrome: a systematic review and meta-analysis of randomized controlled trials. J Man Manip Ther. 2024;32(2):71-85.Nejati P, Safarcherati A, Karimi F. Effectiveness of exercise therapy and manipulation on sacroiliac joint dysfunction: a randomized controlled trial. Pain Physician. 2019;22(1):53-61.Kamali F, Zamanlou M, Ghanbari A, Alipour A, Bervis S. Comparison of manipulation and stabilization exercises in patients with sacroiliac joint dysfunction: a randomized clinical trial. J Bodyw Mov Ther. 2019;23(1):177-182.Bialosky JE, Bishop MD, Price DD, Robinson ME, George SZ. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. J Orthop Sports Phys Ther. 2009;39(3):123-130.Testa M, Rossettini G. Enhance placebo, avoid nocebo: how contextual factors affect physiotherapy outcomes. Phys Ther. 2016;96(11):1541-1549.Shahali S, Ebrahimian MR, Hosseinifar M, et al. Effects of motor control exercise on pain and disability in patients with sacroiliac joint pain: a systematic review and meta-analysis. Musculoskelet Sci Pract. 2021;56:102419.Visser LH, Woudenberg NP, de Bont J, et al. Treatment of the sacroiliac joint in patients with leg pain: a randomized controlled trial. Eur Spine J. 2Go to PT Final Exam using this link to access great studying options to conquer the NPTE!Support the showStay Connected! Follow so you never miss an episode. Send your questions via email to ptsnackspodcast@gmail.com Join the email list HERE Need CEUs or NPTE Prep? Save over $100 on unlimited CEUs with MedBridge using code PTSNACKSPODCAST at checkout. Students: Get a full year of access for less with code PTSNACKSPODCASTSTUDENT. Prepping for the NPTE? PT Final Exam offers all the tools you need. Use code PTSnacks at checkout to get a discount! Support the ShowShare the episode with someone who'd benefit. Contributing directly to the "support" link. Thanks for tuning in—your support makes this all possible!

Sen and Erica welcome Sarah Shipp as she hosts her Thinking Beyond Mechanism series. In this episode, she discusses the permissions that games and their rules give us to break social conventions within the construct of the so-called "Magic Circle".

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Injectable Glutathione: 2025 Update & Comprehensive GuideHey everyone, it's Hunter Williams here! In today's video, I bring you my 2025 update on glutathione, particularly injectable glutathione. I've used it for years and continue to be amazed by its benefits. This video expands on my previous content with newer clinical evidence and informed recommendations. We'll discuss its role in mitigating the effects of mitochondrial peptides, combating environmental stressors, and maintaining liver health. I'll delve into the bioavailability challenges of oral glutathione versus injectables, specific use cases like liver disease, male fertility, and even chemotherapy support. Plus, I'll share how to properly administer it, monitor its effects, and my personal insights on how it enhances energy, immune function, and overall well-being. Don't miss out on this detailed and informative guide—perfect for anyone into peptide research or looking to optimize their health! As always, check the links in the description, and don't forget to join my email list for updates. Thanks for your continuous support. Let's dive in!00:00 Introduction and Video Overview02:39 What is Glutathione?03:47 Bioavailability and Delivery Methods06:06 Mechanisms of Action and Benefits08:41 Clinical Applications and Case Studies25:27 Dosing Guidelines and Best Practices28:48 Conclusion and Final Thoughts

Radhika Das, IFN Journalist, interviews Fahad Hamad Al-Sulaiti, Director General, Qatar Fund For Development (QFFD), on the role QFFD sees for the private sector in scaling impact through different financing mechanisms and the organization's Islamic finance involvement

CODEPINK World Court Campaign Coordinator Robert Jereski: After Gaza Hostage/Prisoner Exchange, Ceasefire Lacks Enforcement MechanismsU.S. Marine veteran Bryce Lockwood: Recounting Israel's 1967 Attack on U.S. Research Ship during Six-Day War and Its Lasting ImpactFormer health insurance executive turned whistleblower Wendell Potter: Federal Government Shutdown Exposes Crisis in Long Failing U.S. Healthcare SystemBob Nixon's Under-reported News Summary• Brazil's Jair Bolsonaro, convicted of coup plot, running out of options• Russia, Vietnam can avoid U.S. sanctions with backdoor energy enterprise• Puerto Ricans' mutual aid food system could be a model post-natural disastersVisit our website at BTLonline.org for more information, in-depth interviews, related links and transcripts and to sign up for our BTL Weekly Summary. New episodes every Wednesday at 12 noon ET, website updated Wednesdays after 4 p.m. ETProduced by Squeaky Wheel Productions: Scott Harris, Melinda Tuhus, Bob Nixon, Anna Manzo, Susan Bramhall, Jeff Yates and Mary Hunt. Theme music by Richard Hill and Mikata.

Cancer now affects 30% to 50% of Americans, a massive increase from just 5% in 1900, reflecting how modern diets and lifestyles have reshaped your body's internal terrain Excess linoleic acid (LA) from seed oils triggers toxic byproducts, chronic inflammation, and mitochondrial breakdown, all of which weaken your body's defenses and fuel tumor growth Lowering LA intake from 7% to around 2% to 3% of daily calories has been shown to cut oxidative stress markers by 20% in as little as 12 weeks, giving your body a chance to recover A four-phase terrain restoration strategy uses seed oil elimination, staged carbohydrate reintroduction, gradual fiber restoration, and metabolic supports like intermittent fasting and exercise to rebuild resilience Simple daily steps — avoiding seed oils, rebuilding gut health, supporting mitochondria through movement and sleep, and tracking progress — give you control over your risk and long-term health

Sodium bicarbonate is one of the most consistently supported ergogenic aids in sports nutrition research, yet its underlying mechanisms and real-world applications remain widely misunderstood. More recent developments have focused on how to optimise both the timing and formulation of supplementation. The “individualised ingestion timing” approach has emerged as a practical strategy, recognising that the time-to-peak blood bicarbonate concentration varies considerably between individuals. Similarly, novel formulations are being explored to address issues with gastrointestinal distress and practicality of dosing. These include topical approaches such as sodium bicarbonate lotion, and commercial products like Maurten's “Bicarb System.” In this episode, Prof. Lewis Gough joins to discuss the latest evidence on sodium bicarbonate and performance, its mechanisms, novel delivery systems, and the key directions for future research. Dr. Lewis Gough is Associate Professor in Nutrition and Physiology at Birmingham City University. He is globally recognized for his research on sodium bicarbonate supplementation in sport, and his work spans applied sport and exercise nutrition, exercise metabolism, acid–base balance, and fatigue. Timestamps [03:12] Professor Gough's academic journey [06:29] Mechanisms of sodium bicarbonate and historical perspective on lactate [11:21] Sodium bicarbonate's role in performance [22:45] Individual responses to sodium bicarbonate [26:53] Timing strategies for sodium bicarbonate [32:38] Individualized approach to sodium bicarbonate timing [36:47] Traditional vs. novel delivery methods [44:27] Practical recommendations for athletes [51:18] Future research directions [01:02:08] Key Ideas segment Resources Go to episode page (w/ links to relevant studies) Subscribe to Sigma Nutrition Premium Join the Sigma email newsletter for free Enroll in the next cohort of our Applied Nutrition Literacy course See all of Sigma's "Recommended Resources"

Sam Miller is a respected educator and authority on metabolism and founder of Metabolism School. Sam guests on my podcast to share his expertise on:-The implications of the dramatic rise in GLP-1 Agonist medication use -The situations where GLP-1 Agonist medication use makes sense and where it's inappropriate -Potential benefits outside appetite suppression and weight loss-Nuance about the potential side effects -The importance of strength training when using these drugs-Reverse dieting, what it is, when it's appropriate -Situations where reverse dieting may be harmful -The role ultra processed foods play in the obesity and metabolic unhealth epidemic -Are all ultra processed foods problematic-And much more00:30 GLP-1 Medications: Popularity and Usage01:33 Mechanisms and Effects of GLP-103:10 Broader Implications and Side Effects11:26 Resistance Training and Muscle Preservation17:44 Nuances of GLP-1 Use in Different Populations27:15 Famous Athletes and Weight Struggles27:41 The Trend of Reverse Dieting28:39 Concerns with Reverse Dieting30:57 Effective Reverse Dieting Strategies43:11 The Role of Ultra-Processed Foods in Health51:58 Conclusion and ResourcesI've been putting a lot of time and effort into making these new episodes valuable for you. You can help me get these great guests and their knowledge in front of more people by:-Subscribing and checking out more episodes-Sharing on your social media (please tag me - I promise I'll respond)-Sharing with the friend you think of who needs this episodeFollow Andrew Coates:Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@andrewcoatesfitness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Join My Email List:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.andrewcoatesfitness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get the RP App at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.rpstrength.com/coates⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ - use the code COATESRPUse Code ANDREWCOATESFITNESS to save 10% off at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://justbitememeals.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Use MacrosFirst for tracking nutrition ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.macrosfirst.com/⁠⁠Go to www.knkg.com/Andrew59676 for 15% off your KNKG bag.Get a discount on Versa Gripps at www.versagripps.com/andrewcoates

In this episode, Dr. Shaun Jackson uses a compelling patient case to illuminate the complex mechanisms of immune tolerance and autoimmunity. He explains how B cells learn to avoid targeting the body's own tissues through central and peripheral tolerance—and how these safeguards can fail. The discussion covers the roles of germinal centers, T cells, and rare genetic disorders in shaping immune regulation, with Alport's syndrome and post-transplant Goodpasture's disease serving as striking examples. Dr. Jackson also reflects on emerging directions in autoimmune research and shares his journey from medical training in South Africa to leading a research program in Seattle, offering valuable insights for future physician-scientists. 

Professors Bas Bloem and Werner Poewe explore the underlying mechanisms of Parkinson's disease and discuss current and emerging therapeutic approaches. A clear and insightful conversation for anyone seeking to better understand the science behind PD and its treatment.

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Timestamps00:00 Introduction and Video Overview00:14 Oxytocin and Its Connection to Fat Loss01:16 Scientific Data and Research on Oxytocin02:30 Mechanisms of Oxytocin in Fat Loss04:23 Oxytocin's Effects on Appetite and Metabolism05:29 Comparing Oxytocin with Other Weight Loss Aids10:37 Direct Actions of Oxytocin on Fat Cells11:59 Animal and Human Studies on Oxytocin19:26 Oxytocin Usage Protocols24:33 Potential Side Effects and Safety26:56 Conclusion and Final ThoughtsJoin me, Hunter Williams, as I delve into the fascinating connection between oxytocin—the 'love hormone'—and its surprising benefits for fat loss. Discover the scientific data and practical insights that show how this peptide hormone can enhance muscle preservation, improve metabolism, and reduce cravings for high-fat foods. Learn the optimal ways to use oxytocin, including dosing protocols and the synergy with diet and exercise. Don't forget to stay connected by joining my email list for updates on new videos and content. Let's dive in and explore how oxytocin can support your fitness and wellness journey!

Featuring an interview with Dr Ghayas Issa, including the following topics: Mechanism of action and efficacy of menin inhibitors (0:00) Presentation and management of differentiation syndrome (13:31) Role of menin inhibitors in other cancers (18:19) Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51) Mechanisms of resistance to menin inhibition in AML (26:53) Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31) Mechanism of action of menin inhibitors as differentiation agents (38:05) Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55) Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25) Other investigational therapeutic strategies in AML (54:39) CME information and select publications

Featuring a slide presentation and related discussion from Dr Ghayas Issa, including the following topics: Evolution of menin inhibitors for acute myeloid leukemia (AML) (0:00) Side effects of menin inhibition (10:54) Mechanisms of resistance to menin inhibition in AML (15:08) CME information and select publications

Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/00:00 Introduction and Video Overview00:20 Personal Experience with SS 3101:43 Scientific Basis and Human Trials03:25 Mechanisms of SS 3107:37 Clinical Applications and Benefits14:46 Dosing Guidelines and Safety21:21 Emerging Applications and Future Potential26:51 Conclusion and Final ThoughtsIn this comprehensive deep dive into SS-31, I'll be sharing my personal experience with this powerful mitochondrial peptide, its scientific mechanisms, clinical applications, dosing guidelines, and the outstanding benefits observed in various human trials. Whether you're looking to enhance your energy levels, improve athletic performance, or support your cardiovascular and cognitive health, SS-31 offers promising solutions. Don't miss out on this essential biohacking tool!

Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one's for you.Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.comSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Hettas: Use code FEISTY20 for 20% off at https://hettas.com/ Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% off This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy

Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.