Hair follicles are dynamic structures that undergo cyclic phases of growth, regression and quiescence. The growth phase, known as anagen, lasts for several years, followed by a short regression phase called catagen. During catagen, most cells within the follicle undergo programmed cell death, but a small population of stem cells remains viable to replenish the follicle during the subsequent growth phase. Understanding the mechanisms involved in hair follicle regression is not only important for elucidating normal tissue homeostasis but also for studying pathological conditions such as cancer and aging. In a recent study, researchers Bradley D. Keister, Kailin R. Mesa and Krastan B. Blagoev from the National Science Foundation, The Jane Coffin Childs Memorial Fund for Medical Research, Yale School of Medicine, Johns Hopkins University, Bulgarian Academy of Sciences, and Sorbonne Université shed light on the role of apoptotic cells in hair follicle regression and cell death. Their research paper was published in Oncotarget on October 19, 2023, entitled, “Apoptotic cells may drive cell death in hair follicles during their regression cycle.” “Here, we use a quantitative analysis of the length of hair follicles during their regression cycle.” Full blog - https://www.oncotarget.org/2023/11/29/can-mechanisms-of-hair-loss-shed-light-on-cancer-and-aging/ Paper DOI - https://doi.org/10.18632/oncotarget.28529 Correspondence to - Krastan B. Blagoev - firstname.lastname@example.org Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28529 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, hair follicle, stem cells, regression cycle, mathematical model, analysis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
In this thought provoking episode, we take a step back from profiling individuals cases, to lay the groundwork for understanding the complex world of serial killers. Dr. Jerrod Brown, a familiar voice and revered figure in the field, joins us to demystify the phenomenon of serial killers, challenging common myths and bringing to light the pivotal role of neurocriminology. From discussing the significance of a serial killer's signature behaviors to noting the Trauma Control Model, this episode is an immersive journey into the psychological and behavioral patterns that define some of the most notorious criminals. We delve into how Attachment Disruption, stemming from excessive trauma, influences an individual's capacity for forming relationships, and potentially, their path into criminality. This episode is not about sensationalizing the macabre, but about equipping practitioners in criminal justice and human services with the knowledge to identify and manage behaviors indicative of deeper issues. Join us for an educational expedition into the minds of those who commit these crimes and discover how this knowledge can apply to a broader spectrum of case work. Become a Neurocriminology Informed Professional! Dr. Jerrod Brown bio The Paragon Group
Dr. Tesha Monteith talks with Dr. Messoud Ashina about the mechanisms of migraine. Articles Referenced in this Episode: Calcitonin Gene-related Peptide Causes Migraine Aura An Exploratory Analysis of Clinical and Sociodemographic Factors in CGRP-induced Migraine Attacks: A REFORM Study Disclosures can be found at Neurology.org
In this accredited podcast episode, Dr Christina Madison and Dr Mary Bridgeman discuss the latest practical strategies for preventing RSV infection in older adults, including: Role of basic public health precautionsAvailable and emerging vaccines Mechanisms of action, therapeutic targets, and pharmacologyEfficacy and safety dataFDA approval status and ACIP recommendations Presenters: Mary Barna Bridgeman, PharmD, BCPS, BCGP, FASCP, FCCP, FNAPClinical ProfessorErnest Mario School of PharmacyRutgers, The State University of New JerseyPiscataway, New JerseyInternal Medicine PharmacistRobert Wood Johnson University HospitalNew Brunswick, New JerseyChristina M. Madison, PharmD, FCCP, AAHIVP Clinical PharmacistFounder and CEO, The Public Health Pharmacist, PLLCAdjunct Associate Professor of Pharmacy PracticeRoseman University of Health SciencesCollege of PharmacyHenderson, NevadaOther program activities: • Frontiers in RSV Prevention for Older Adults: Developments, Recommendations, and the Pharmacist's Role
In this episode:What are curly arrows showingWhy we use a curved arrowMaking a new bondBreaking a bondA special case with two arrowsBecome a Patreon supporter of the podcast and get more from each episode. patreon.com/chemistrymadesimplePrefer to say a quick 'thank you'? You can buy me a coffee if that's your jam.Check out the Chemistry Made Simple academyFind out more about the Chemistry Made Simple academyContact me:Instagram @chemistrymadesimpleEmail Matthew@ChemistryMadeSimple.netJoin the discussion at the Chemistry Made Simple podcast community.
Join Sarah and Skye as they explore the potential links between ADHD and dyslexia, dyscalculia and other neurodivergence. The pair also discuss the individual differences in ADHD traits and how they present across the wider population. Could ADHD symptoms be a bell curve? Tune in to find out.The ADHD AcademyUnconventional OrganisationComorbidity and causality among ADHD, dyslexia, and dyscalculia.Neurocognitive Profile in Children with Attention Deficit/Hyperactivity Disorder and Dyslexia. Mechanisms of cognitive disinhibition explain individual differences in adult attention deficit hyperactivity disorder traits.
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayThis is the Second last episode of the SEASON-2 (All about ANS)In this episode, I will be describing the major features, Pharmacokinetics, Mechanisms, uses and side effects of Third generation Beta blocking drugs like Carvedilol, Labetalol, Bucindolol, Celiprolol, Bevantolol, Betaxolol, Nipradilol, Nebivolol, etcThese would be the whole episode talk and it will be very useful to comprehend the various aspects and applications of these very important drugs. Their main use is to control Hypertension and they find use in CHF, MI, etc,.I will be wrapping up the episode with information and latest developments at my end like about next and last episode of Season2 i.e. rapid fire round revision of miscellaneous drugs,"Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comFor all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Substack!Connect on Twitter & Instagram!My books on Amazon & Goodreads!
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayThis is the Second last episode of the SEASON-2 (All about ANS)In this episode, I will be describing the major features, Pharmacokinetics, Mechanisms, uses and side effects of Third generation Beta blocking drugs like Carvedilol, Labetalol, Bucindolol, Celiprolol, Bevantolol, Betaxolol, Nipradilol, Nebivolol, etc These would be the whole episode talk and it will be very useful to comprehend the various aspects and applications of these very important drugs. Their main use is to control Hypertension and they find use in CHF, MI, etc,.I will be wrapping up the episode with information and latest developments at my end like about next and last episode of Season2 i.e. rapid fire round revision of miscellaneous drugs,"Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comFor all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! Please leave Review on Apple podcasts! My E-Newsletter sign up at Substack! Connect on Twitter & Instagram! My books on Amazon & Goodreads!
In this episode, Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections involving Pseudomonas aeruginosa with difficult-to-treat resistance, including: Mechanisms of β-lactam resistanceEffect of resistance mechanism on susceptibility to antipseudomonal agent2023 IDSA guidance recommendations Activity against newer antipseudomonal β-lactams in the United StatesThe latest clinical data by antimicrobial regimen: - Ceftolozane/tazobactam - Ceftazidime/avibactam - Imipenem/cilastatin/relebactam - CefiderocolApplying antimicrobial stewardship principlesProgram Director:Trevor Van Schooneveld, MD, FSHEA, FACP Professor, Division of Infectious DiseasesProgram Director, Infectious Diseases FellowshipMedical Director, Antimicrobial Stewardship ProgramUniversity of Nebraska Medical CenterOmaha, NebraskaFaculty:Emily Heil, PharmD, MS, BCIDP, AAHIVPAssociate ProfessorDepartment of PharmacyUniversity of Maryland School of PharmacyID Clinical Pharmacy SpecialistUniversity of Maryland Medical Center|Baltimore, MarylandLaila Woc-Colburn, MDAssociate ProfessorDivision of Infectious DiseasesEmory University School of Medicine Atlanta, GeorgiaContent based on a CME program supported by an educational grant from Merck & Co., Inc., Rahway, NJ, USA.Follow along with a downloadable slideset at: https://clinicaloptions.com/CE-CME/infectious-disease/cmv-prevention-in-sot-recipients/26139Link to full program: https://bit.ly/40HyvPy
We are going to combine all of our favorite topics — red light therapy, the mitochondria and methylene blue — into this brain-centric episode. We know that the brain is the most mitochondrial-dense tissue in the body and, thus, photobiomodulation (namely, near-infrared light) can have a very positive effect. We also know that most of the methylene blue ingested eventually accumulates in the brain, which is why it has countless brain-boosting benefits. However, when it comes to mitochondrial function it's a double-edged sword. The health of your mitochondria can (of course) work for you or against you. And when the function of your mitochondria declines, it will likely show up in those tissues that are mitochondrial-dense (i.e., tissues that require the most amount of energy to function). Our nervous system is extremely energy-intensive and the brain is the king/queen of the nervous system. Thus, when mitochondrial dysfunction strikes, it hits the nervous system — and particularly the brain — hard. This largely explains why neurodegenerative diseases are an every-increasing presence in our modern-day world. While this may all seem like sobering and dire news, there is a silver lining that can put you back at ease. Again, while mitochondrial dysfunction can work against you, as long as you harness tactics that boost mitochondrial health (and, thus, inherently prevent, mitigate and sometimes even reverse mitochondrial dysfunction), then you are well on your way to staving off neurodegenerative disease. In today's episode, methylene blue takes center stage as we dig into the research to see how this spectacular salt can buoy your mitochondrial health and play a pivotal role in numerous neurodegenerative diseases. As always, light up your health! - Key Points: Intro & Weather (00:00:00 - 00:02:25) Montana weather update and Dr. Mike's snow aversion Holidays & BioLight Sale (00:02:25 - 00:03:24) Mention of approaching holidays Announcement of pre-Black Friday sale at BioLight Upcoming Interviews & Office Hours (00:03:24 - 00:05:53) Encouragement to subscribe and introduction of Instagram Live office hours Details about the purpose, structure, and inaugural session of office hours Significance of two-way communication and bridging gaps in red light therapy education Main Topic: Mitochondrial Dysfunction (00:12:03 - 00:15:14) Introduction and eagerness to explore mitochondrial dysfunction Consequences and treatment strategies discussed Microtherapy and Treatment Strategies (00:18:24 - 00:21:19) Introduction to "microtherapy" and various treatments Announcement of an e-book Mitochondria's Role in Health (00:21:19 - 00:24:16) Emphasis on overall health and lifestyle impact Exploring Methylene Blue (00:24:16 - 00:26:54) Introduction to "From Mitochondrial Function to Neuroprotection" Historical background and BioLight product announcement Methylene Blue's Mechanisms (00:26:54 - 00:30:05) Effectiveness, historical evolution, psychiatric applications, and MAOI function discussed Mitochondrial Function and Methylene Blue (00:30:05 - 00:33:07) Importance of mitochondrial function and overview of the electron transport chain Methylene Blue's Role in Mitochondrial Dysfunction (00:33:07 - 00:35:52) Promotion of complex four activity Tau aggregation in Alzheimer's Methylene Blue in Alzheimer's and Parkinson's (00:35:52 - 00:37:12) Preservation of electron transport chain function Behavioral improvements in Parkinson's Benefits and Combination Therapy (00:37:12 - 00:39:21) Potential benefits with levodopa and emphasis on investigating safety Methylene Blue in Traumatic Brain Injury (00:39:21 - 00:40:01) Transition to TBI discussion Encouragement to use remedies promptly Preclinical Studies on Methylene Blue (00:40:01 - 00:41:15) Overview of TBI studies and quick administration's impact on outcomes Effectiveness of Methylene Blue (00:41:15 - 00:43:37) Studies showing effectiveness post-TBI Likelihood of combination therapy efficacy Cognitive Enhancement and Aging (00:43:37 - 00:52:40) Exploration of cheaply available compounds and Methylene Blue's potential in cognitive enhancement Protection against age-related decline Neurogenesis and mitochondrial health Conclusion and BioLight Product (00:52:40 - 00:55:53) Summary of article focus and BioLight's enhanced methylene blue product Closing (00:55:58:15 - 00:56:53:08) Dr. Mike's recommendation to explore BioBlue Encouragement to share information - Articles referenced in the episode: Mitochondrial dysfunction and neurological disorders: A narrative review and treatment overview From Mitochondrial Function to Neuroprotection—an Emerging Role for Methylene Blue - Learn more about methylene blue & BioBlue: Methylene blue BioBlue - Dr. Mike's #1 recommendations: Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light blocking glasses: Ra Optics - To learn more about red light therapy, methylene blue and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn BioLight: Instagram YouTube Facebook
In this episode, Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections involving carbapenem-resistant Acinetobacter baumannii (CRAB), including: Mechanisms for β-lactam resistanceAdditional resistance mechanisms and virulence factors2023 IDSA guidance recommendations for moderate to severe CRAB infectionsThe latest clinical data by antimicrobial therapy/regimen:SulbactamMeropenem and colistinCarbapenem, sulbactam, and polymyxin BTetracyclinesCefiderocolSulbactam/durlobactam and carbapenems Program Director:Trevor Van Schooneveld, MD, FSHEA, FACP Professor, Division of Infectious DiseasesProgram Director, Infectious Diseases FellowshipMedical Director, Antimicrobial Stewardship ProgramUniversity of Nebraska Medical CenterOmaha, NebraskaFaculty:Emily Heil, PharmD, MS, BCIDP, AAHIVPAssociate ProfessorDepartment of PharmacyUniversity of Maryland School of PharmacyID Clinical Pharmacy SpecialistUniversity of Maryland Medical CenterBaltimore, MarylandLaila Woc-Colburn, MDAssociate ProfessorDivision of Infectious DiseasesEmory University School of Medicine Atlanta, GeorgiaContent based on a CME program supported by an educational grant from Merck & Co., Inc., Rahway, NJ, USA.Follow along with a downloadable slideset at: https://bit.ly/476v2wILink to full program: https://bit.ly/40Mmicz
In this episode:Definition of MechanismHow a mechanism tells more than an equation or a simple diagramDefinition of electrophile with examplesDefinition of nucleophile with examplesBecome a Patreon supporter of the podcast and get more from each episode. patreon.com/chemistrymadesimplePrefer to say a quick 'thank you'? You can buy me a coffee if that's your jam.Check out the Chemistry Made Simple academyFind out more about the Chemistry Made Simple academyContact me:Instagram @chemistrymadesimpleEmail Matthew@ChemistryMadeSimple.netJoin the discussion at the Chemistry Made Simple podcast community.
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayThis is the festive episode on the DIWALI day (2023) about Beta-1 Selective Antagonistic agents.Wishing everyone a Happy, Healthy, Wealthy Diwali '23 and great new year and season's greetings ahead!!In this episode, I will be describing the major features, Pharmacokinetics, Mechanisms, uses and side effects of Beta-1 Selective drugs like Metoprolol, Atenolol, Esmolol, Acebutolol, Bisoprolol and BetaxololThese would be the whole episode talk and it will be very useful to comprehend the various aspects and applications of these very important drugs.I will be wrapping up the episode with information and latest developments at my end like "Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comFor all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!Please leave Review on Apple podcasts!My E-Newsletter sign up at Substack!Connect on Twitter & Instagram!My books on Amazon & Goodreads!
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika VijayThis is the festive episode on the DIWALI day (2023) about Beta-1 Selective Antagonistic agents.Wishing everyone a Happy, Healthy, Wealthy Diwali '23 and great new year and season's greetings ahead!!In this episode, I will be describing the major features, Pharmacokinetics, Mechanisms, uses and side effects of Beta-1 Selective drugs like Metoprolol, Atenolol, Esmolol, Acebutolol, Bisoprolol and Betaxolol These would be the whole episode talk and it will be very useful to comprehend the various aspects and applications of these very important drugs.I will be wrapping up the episode with information and latest developments at my end like "Pharmacology Further" E-Newsletter and Podcast:The links for these are at all my websites and specifically:Link for E-Newsletter: https://pharmacologyfurther.substack.com/Link for the E-Newsletter Podcast: https://www.pharmacologyfurther.comFor all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine.It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! Please leave Review on Apple podcasts! My E-Newsletter sign up at Substack! Connect on Twitter & Instagram! My books on Amazon & Goodreads!
At SupplySide West 2024, one of the biggest events was a panel discussion held at the Kyowa Hakko USA booth, featuring a star-studded cast of influential industry advocates: Dan LourenÃ§o – Founder and CEO of Ghost Joey Savage – Chief Scientific Officer of Glaxon Chris Lockwood – VP of Scientific Affairs at Nutrabolt David Sandler – Scientific Consultant and COO of Jupiter Wellness The topic of the panel was The Growth of Branded Ingredients, with an initial focus on Cognizin Citicoline, an ingredient used by everyone listed above. The episode offers fresh and unique perspectives from each member, who have different reasons and purposes for various ingredients. When you're as big as these brands, you have to rely on trusted and legally compliant inputs, and few in this industry are as trusted as Kyowa Hakko! Embracing branded ingredients and collaborative competition This was a hallmark moment for the dietary supplement industry — one that we call “collaborative competition”. To put it bluntly, a panel like this simply wouldn't have happened 5+ years ago. But with a growing industry where all good players can win, and companies like PricePlow and Kyowa Hakko here to bring a network of forward-thinking industry advocates together, it's now a reality. With this, we get more information, less duplication of mistakes, and the consumer is ultimately the beneficiary. https://blog.priceplow.com/podcast/kyowa-branded-ingredients-ssw-2023 Video Version: Watch Dan, Joey, and Chris Talk Branded Ingredients https://www.youtube.com/watch?v=PjpmO_3nsk0 Audio Version available for download Detailed Show Notes: Embracing Branded Ingredients with Kyowa at SSW 2023 (0:00) – Introductions and Branded Ingredients (1:45) – Why use Cognizin in supplement formulations? (4:30) – Cognizin Citicoline vs Alpha-GPC (5:00) – Energy, Focus, and Nootropics – Where to Next? (8:45) – Why branded ingredients? (14:15) – Operating in the Information Age (17:15) – Ingredient Suppliers Need to Know their Mechanisms (18:15) – How Important is Flavoring? What if it attracts kids? (24:00) – Ingredients that Don't Taste Well (32:00) – Immune: Kyowa Hakko's Immune Support Postbiotic Ingredient (35:45) – Branded Ingredients in Functional Foods? (41:00) – Trojan Horsing In Healthy Ingredients Where to Follow Everyone Kyowa Hakko USA on LinkedIn Follow PricePlow's Kyowa Hakko news Dan LourenÃ§o on LinkedIn Follow PricePlow's Ghost Lifestyle news Joey Savage on LinkedIn Follow PricePlow's Glaxon news Chris Lockwood on LinkedIn Follow PricePlow's Cellucor news … Read more on the PricePlow Blog
The genre of worker placement games is quite large and has evolved a lot over the years. Traditionally, worker placement was all about certain actions being unavailable to other players as soon as someone placed their worker there. At some point, games introduced shared worker place spots. Some games allowed players to kick workers out, returning them to another player who would effectively get another go. In this article, I want to look at the genre and pick out different implementations and variations on the theme. Read the full article here: https://tabletopgamesblog.com/2023/11/07/working-hard-a-look-at-worker-placement-mechanisms-topic-discussion/ Useful Links Lords of Waterdeep: https://dnd.wizards.com/products/lords-waterdeep-board-game Agricola: https://www.asmodee.co.uk/collections/agricola Raiders of the North Sea review: https://tabletopgamesblog.com/2023/05/27/raiders-of-the-north-sea-digital-eyes/ Viticulture review: https://tabletopgamesblog.com/2020/08/15/viticulture-essential-edition-saturday-review/ Genotype review: https://tabletopgamesblog.com/2021/06/26/genotype-a-mendelian-genetics-game-saturday-review/ I C E: https://thiswayeditions.com/ice/ Hegemony: https://hegemonygame.com/ Pingyao: First Chinese Banks review: https://tabletopgamesblog.com/2023/01/21/pingyao-first-banks-of-china-saturday-review/ Intro Music: Bomber (Sting) by Riot (https://www.youtube.com/audiolibrary/) Music: BensoundLicense code: 4Z99RQPZCN8LR59B Music by Bensound.comLicense code: EUUQE9AJCKFYWYYA Patreon: https://www.patreon.com/tabletopgamesblog Ko-Fi: https://ko-fi.com/TabletopGamesBlog Website: https://tabletopgamesblog.com/ --- Send in a voice message: https://podcasters.spotify.com/pod/show/tabletopgamesblog/message
In a debut format, host Shawn Rostker presents a narrated version of a peer-reviewed journal article from Nick Lekkas, a senior columnist at the Georgetown Security Studies Review and fellow SSP colleague. Nick's article, titled “Mobilized, Forgotten, Ignored: Russia's Control Mechanisms of its Minority Populations Amid the Russo-Ukrainian War,” explores the disproportionate effect that Russia's conscription efforts have had on ethnic groups from the Buryat, Kuban, and Dagestan regions. Nick analyzes the Kremlin's political motivations for sparing its Slavic population from front-line deployment, and explains why this imbalance may become a greater vulnerability for the Russian regime than it realizes.
Dr Glenn McConell chats with Professor Sue Bodine from the Oklahoma Medical ResearchFoundation, Oklahoma, USA. She is an expert on muscle, in particular muscle atrophy with inactivity/aging. We chatted about how with age muscle size is reduced and this is associated with a reduction in muscle fiber size and also a loss of fast muscle fibers. Resistance training (and perhaps intense endurance exercise) can attenuate the rate of muscle atrophy. We discussed how much muscle atrophy is due to age per se and how much is due to inactivity. Anabolic resistance, protein synthesis, the importance of strength for balance etc. A very interesting chat.0:00. Introduction + how Sue got into exercise research5:25. What determines muscle strength7:20. What age do we start losing muscle mass and strength?8:40. Muscle atrophy and loss of fast muscle fibers13:10. Can exercise training reduce the loss of fast fibers with age?17:50. How muscle of muscle atrophy with age in inactivity?19:20. Anabolic resistance with age20:40. A role of hormones in muscle atrophy with age?22:30. Protein synthesis and turnover in muscle with aging26:46. How much exercise is needed to attenuate muscle atrophy?30:30. Aging vs inactivity vs immobilizing vs bed rest etc33:30. Importance of exercise after bed rest/immobilization37:27. Upper body atrophy in runners/cyclist etc39:55. Intense endurance exercise and slow muscle fiber size43:00. Need to actually work out not just turn up44:42. Exercise prescription with aging47:05. Balance with age/inactivity48:45. Diet and muscle atrophy50:00. Need a stimulus (ex training) not eating more protein54:52. Disease processes and muscle atrophy58:10. Mechanisms playing a role in muscle atrophy/hypertrophy1:08:53. Don't need to break down muscle to build muscle1:10:40. Determining muscle quality/specific tension13:02. Are slow fibers really weaker than fast fibers?1:17:22. Takeaway messages1:18:53. Can very old people still get stronger/hypertrophy?1:19:50. Do females really hypertrophy less?1:22:00. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: email@example.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice
“Interpersonal issues should be dealt with by the individuals, and team issues should be dealt with by the team collectively… I think most team leaders and team members would absolutely agree with that because, as you say, issues that pop up with individuals on the team, they're going to spill over into the team. And so what we're offering here is that early detection tool to prevent this very thing from happening.” - Winnie da SilvaIn this podcast episode, Winnie and Peter discuss the importance of continuous improvement mechanisms within teams. They highlight that, despite most teams wanting to continuously improve, they often struggle with how to do it. Peter and Winnie provide practical ways to implement mechanisms for ongoing improvement.Episode Highlights:Analogy from ManufacturingPeter shares an analogy from his experience working with manufacturing teams that use sensors in equipment in order to detect problems early. This mindset is about monitoring and early detection, ensuring corrective action can be taken before issues escalate.The Need for Continuous ImprovementPeter emphasizes the importance of continuous improvement mechanisms in maintaining and increasing team effectiveness over time. Teams that invest in these mechanisms become more effective, while those that don't tend to become less effective.The Challenge of TimePeter acknowledges that time is a common barrier to investing in continuous improvement mechanisms. Many teams may feel they don't need it or that their current processes are "good enough." Winnie and Peter argue that these mechanisms are crucial for building a truly effective team.Three Continuous Improvement MechanismsWinnie introduces three important continuous improvement mechanisms:Ongoing exchange of honest feedback between team members.Regular evaluation of team meetings.Team effectiveness checkpoints.Feedback ExchangeWinnie and Peter stress the importance of an ongoing exchange of honest feedback between team members. Regular feedback is critical for maintaining good interpersonal relationships in the face of changing workplace dynamics.They share two favorite questions for requesting feedback: "What am I doing that you appreciate most, and why?" and "What would you like me to do differently, and why?" The benefits of regular feedback include faster problem-solving, improved job performance, better processes, increased trust, conflict reduction, and more.Feedback's ImpactPeter mentions that their work on feedback skills has a lasting and substantial impact, with people sharing stories of how feedback has helped them even years after their engagement.Separating Personal and Team IssuesWinnie emphasizes the importance of addressing interpersonal issues individually and team issues collectively. Feedback exchanges help resolve interpersonal issues effectively.Meeting EvaluationsPeter discusses the significance of regular evaluations of team meetings, particularly during periods of change. Effective meetings can contribute to team success.He mentions various methods for conducting meeting evaluations, such as using Trello or Slack.Using Evaluation InputWinnie and Peter explain that the input collected from meeting evaluations can help meeting facilitators propose process tweaks to the team.They emphasize the importance of conducting evaluations frequently during periods of significant change in meeting processes.Team Effectiveness CheckpointsThe third continuous improvement mechanism involves conducting team effectiveness checkpoints, once or twice a year. This "pause and reflect" exercise is intended for an overall assessment of the team's functioning.Questions Used Winnie describes the metrics used in team effectiveness checkpoints. Team members rate the team on five dimensions: quality, efficiency, satisfaction, individual learning, and team learning. Members are then asked specifically about what is supporting and reducing team effectiveness. This is followed by suggested changes to maintain or increase effectiveness.Resistance to Continuous ImprovementWinnie acknowledges the resistance to investing in continuous improvement mechanisms is often due to a lack of time. They encourage teams to experiment with these practices and evaluate the return on investment.Leaders' Role in Continuous ImprovementPeter suggests that leaders should prioritize open and honest discussions that help teams pause and reflect on their functioning. Such discussions are the secret sauce for team effectiveness.ResourcesWinnie da Silva on LinkedIn Get the whole season and the companion guide at Winniedasilva.comE11: Tell Me What You Really Think with Peter Axelson
Dr.Phil Sizer (e-mail, LinkedIn) is interviewed by Skip Gill about managing chronic pain and strategies to connect with and treat patients. Dr. Sizer also gives us an overview of how research innovations become reality and what types of resources are available. This episode contains information that will be interesting for clinicians, educators, and research who want to learn more about chronic pain management and how to navigate the research innovation process.The book Dr. Sizer mentions during this interview is: Mechanisms and Management of Pain for the Physical Therapist, 2nd Edition (2016) by Kathleen A. Sluka. ISBN: 9781496343239. Find out more about the Foundation for Orthopaedic Manual Physical Therapy (FOMPT) and the American Academy of Orthopaedic Manual Physical Therapists (AAOMPT) at the following links:Foundation website: www.aaompt.org/foundationAcademy website: www.aaompt.orgTwitter: @AAOMPTFacebook: https://www.facebook.com/aaompt/Instagram: https://www.instagram.com/officialaaompt/?hl=enPodcast e-mail: firstname.lastname@example.orgPodcast website: https://aaomptpodcast.simplecast.fm
Emotion helps us understand what is important or interesting hence helping survival --- Send in a voice message: https://podcasters.spotify.com/pod/show/david-nishimoto/message
The statement "Simple basic processes can be put together to give a system-complicated behavior, as the brain" refers to the concept of emergent complexity. In this concept, a system made up of multiple simple components can exhibit complex behaviors that the individual components alone cannot. These simple basic processes, when structured in a certain way and interacting with one another, can create a more intricately functioning whole. --- Send in a voice message: https://podcasters.spotify.com/pod/show/david-nishimoto/message
Dr. C. Denise Okafor is an Assistant Professor of Biochemistry and Molecular Biology, and of Chemistry at Pennsylvania State University. Many of the medications we take work by binding to a particular target and either turning off whatever is causing a problem or turning something on that is not working correctly. Denise's research examines how small molecules like drugs find and interact with the targets they are supposed to interact with. She is particularly interested in proteins that can be turned on or off by the small molecules/drugs that they bind with. While science is a large part of Denise's life, she also enjoys reading and writing fiction. Lately, she has been spending much of her free time with her kids, learning dances from Youtube videos and hanging out together. She received her B.S. in biomedical chemistry from Oral Roberts University and was awarded her M.S. in chemistry and a Ph.D. in biochemistry from Georgia Institute of Technology. Afterwards, Denise was selected to complete an Institutional Research and Academic Career Development Award from the NIH to conduct postdoctoral research at Emory University and teach at Morehouse and Spelman colleges in Atlanta. Denise has received a variety of awards and honors for her work, including a Burroughs Wellcome Fund Career Award at the Scientific Interface, an NSF CAREER Award for early investigators, and the NIH Director's New Innovator Award. In addition, she has been named a Keystone Symposia Fellow and a Kavli Foundation Fellow. In our interview, Denise talks more about her life and science.
Beezer Clarkson leads Sapphire Partners‘ investments in venture funds domestically and internationally. Beezer has invested in some of the best firms of a generation including USV and Point Nine to name a few. Beezer began her career in financial services over 20 years ago at Morgan Stanley in its global infrastructure group. Prior to joining Sapphire in 2012, Beezer managed the day-to-day operations of the Draper Fisher Jurvetson Global Network, which then had $7 billion under management across 16 venture funds worldwide. In Today's Episode with Beezer Clarkson We Discuss: LP Landscape: WTF is Going On: Are LPs really all closed for business? What has changed in what LPs want to see from managers they are looking to invest in? What has changed about the size and pace of new commitments for LPs? Are all LPs moving away from growth? 2. 2020-2022: Years in Review: Are LPs frustrated by managers who reduced deployment timelines to 12-18 months? Are LPs frustrated with managers who did not take liquidity when they could have done? How does Beezer advise managers on when and how to take liquidity in their best positions? Are managers accurately marking their portfolios to their LPs today? Why does Beezer believe the incentive mechanism for LPs is broken today in many ways? 3. How To Build a Top Decile Firm: Why does Beezer believe if you want to have the best returns, you have to have one company that returns the fund? Can you not do it with multiple half-fund returners? Is ownership core to all the best firm's top performance? Is it the size of outcome or the size of ownership that drives the best performance across the board? What does data show on how the best funds take significant risk? What are their loss ratios? What are the core tradeoffs to Beezer between scaling AUM and providing top decile returns? 4. LP Markets: The Times They are a Changing: Does Beezer believe LPs will remain cold on large $1BN+ growth firms? Which segments of the market are hot? Which are cold? What are the most significant changes we will see in the LP markets moving forward? Is today the new normal or are we in a downturn that we will come out of?
Mol Cell Biol. 2012 Jan;32(1):126-38 Mutat Res. 2013 Jul-Sep;753(1):24-40 Molecular Neurobiology 2022. volume 59, pages 4223–4241 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
Hey there, welcome back to the Empowered Nutrition Podcast. I'm Erin Skinner, your host, and I'm excited to take you on a journey into the incredible world of Berberine in this episode. Together, we'll discover the superpowers of this natural plant compound and its profound impact on our digestive, metabolic, and hormonal health. Berberine: The Unsung Hero Imagine Berberine as the unsung hero of the supplement world. It's not a prescription drug, but it's gaining superstar status for its unique ability to kickstart the release of glucagon-like peptide-1 (GLP-1). These GLP-1 superpowers are a game-changer in the realm of metabolic health. Safety First: Navigating the Berberine Universe Let's navigate the safety of Berberine. Most adults can embrace its benefits, but we need to be cautious. Expect some minor side effects like mild abdominal discomfort, constipation, or the occasional bout of nausea. But a word of advice, Berberine is best suited for those facing health challenges. For healthy individuals, it may not be the supplement you're looking for. Witness Berberine's Breathtaking Feats Prepare to be wowed by Berberine's breathtaking feats. It swoops in to save the day in the battle against diabetes, polycystic ovary syndrome (PCOS), high cholesterol, and the formidable obesity villain. It's a powerful ally, but having healthcare professionals as your sidekicks when introducing Berberine to your health journey is a smart move. Dosing Drama and Cautious Calm Let's dive into the dosing drama. The script reads 500 milligrams, two to three times a day, for one to six months. Berberine may be a powerful ally, but long-term alliances should be approached with caution. Especially if your medication squad is already on standby. Berberine's Secret Weapons Discover Berberine's secret weapons as I unravel the six primary mechanisms through which it conquers the battlefield. From rallying nitrate-reducing bacteria to amping up short-chain fatty acid production, this hero doesn't back down. It's all part of the grand plan to reduce inflammation, optimize bile metabolism, foster Akkermansia bacteria growth, and control hormones to slay the dragons of appetite and sugar cravings. Calling All Health Warriors Berberine steps into the spotlight when health warriors face particular adversaries. When weight loss resistance, metabolic syndrome, insulin resistance, type 2 diabetes, and PCOS are the battlegrounds, Berberine is your trusty sword. For other quests, consult your healthcare professionals for guidance. Enduring Legacy The awe-inspiring aspect of Berberine? Its enduring legacy. Even after Berberine exits the stage, its impact on the gut microbiome continues to shine. It's like having a guardian angel looking out for your health, long after the final bow. The Final Act As we wrap up this episode, I hope you've gained a newfound appreciation for the superpowers of Berberine. This superhero in supplement form may be your ticket to a healthier, happier future. References used in this podcast episode: 1.The Natural Medicine's Database: Berberine (Professional Monograph) https://info.trchealthcare.com/natmed-ppc 2.Zhang Y, Gu Y, Ren H, et al. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020;11(1):5015. 3.Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020;155:104722. 4.Zhang L, Wu X, Yang R, et al. Effects of Berberine on the Gastrointestinal Microbiota. Front Cell Infect Microbiol. 2020;10:588517. 5.Och A, Och M, Nowak R, Podgorska D, Podgorski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules. 2022;27(4). 6.Cao RY, Zheng Y, Zhang Y, et al. Berberine on the Prevention and Management of Cardiometabolic Disease: Clinical Applications and Mechanisms of Action. Am J Chin Med. 2021;49(7):1645-1666. 7.Wang H, Zhang H, Gao Z, Zhang Q, Gu C. The mechanism of berberine alleviating metabolic disorder based on gut microbiome. Front Cell Infect Microbiol. 2022;12:854885. 8.Li J, Meng P, Zhang J, He M. Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson's Disease Patients. Contrast Media Mol Imaging. 2022;2022:8381870. 9.Ming J, Yu X, Xu X, et al. Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. Genome Med. 2021;13(1):125. Ready to dive in? Listen here! Love it? Hate it? We'd love to hear your feedback! Interested in our Lean for Life Membership? Heal your Metabolism with the Lean for Life app: https://empowered-nutrition.ck.page/193bb2cd67 Help yourself feel aligned using our three phase approach: Lean for Life Membership called Heal, Optimize , and Refinewhere you will be empowered to reverse previous metabolic damage with the assistance of our team of Registered Dietitian Nutritionists. Check out more details on our website! Want to learn more about our one-on-one Empowered Nutrition coaching? Book a free chemistry call to discuss your story and see if we're a good fit. Enjoying the podcast? Please review the Empowered Nutrition Podcast on Apple Podcasts or wherever you listen! Then, send me a screenshot of your positive review to email@example.com as a DM on Instagram (@empowerednutrition.health).Include a brief description of what you're working on with your health and/or nutrition and I'll send you a free custom meal plan! Do you have questions you would like answered on the Empowered Nutrition podcast? 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In this episode of Thinking Beyond Mechanisms, guest host Sarah Shipp discusses some of the terms that designers often talk about (balance, elegance, and efficiency) but turns many of them on their ear to look at them slightly askew. Sarah posits that thinking about these elements in the opposite may help struggling designers recognize their role in creating a game that meets these lofty (and often vague) goals.
Adam is joined by Sophos VP of Market Intelligence Max Weinstein to talk about successful strategies for sales enablement. The two dive deep into Max's three biggest tips for sales enablement, why building a strong relationship with product marketing is essential, and the balance between giving too much context versus not enough. Don't miss your chance to save a seat for the BIGGEST compete event of the year at Compete Week 2022. See more info and the full lineup of speakers at https://klue.com/compete-weekAnd don't forget to sign up for our weekly Coffee & Compete Newsletter for your weekly dose of the best competitive content in the business.To subscribe, visit https://klue.com/newsletterTimestamps:(00:04) Welcome to the Competitive Enablement Show(01:52) Max's three biggest sales enablement tips(05:13) Understanding your sales org inside and out(08:56) Enabling your reps to cross-sell(13:59) Where self-serve enablement comes into play(16:37) Working with sales leadership and management(18:51) Mechanisms for sales enablement and product marketing collaboration (22:54) Enabling your sellers with the right amount of contextProduction Team:Host: Adam McQueenProducer: Ben RonaldPost Production: Grayson OttenbreitAudio Editor: Michael PanesMusic CreditsIntro Music: The Podcast Intro by Music UnlimtedRapid-Fire Music: Los Angeles by MuzaproductionAbout Klue:Klue provides a lens into your competitor's world, continuously updating and connecting dots to help you win more business. It's a new way to capture, manage, and communicate market insights from the web and across the company, in platforms your team already uses
Fourth in a four-part series of special Borderlines episodes with UC Berkeley Law guest hosts Professor Roxanna Altholz and Professor Laurel E. Fletcher shining a spotlight on human rights champions—all guest speakers in their Human Rights Practice Workshop course, where leading practitioners working in a variety of institutional settings share their struggles against corruption and impunity, the relationship between legal and social justice, and the future of human rights movements.Episode 20 of Borderlines showcases guest host Professor Laurel E. Fletcher, Co-Director of Berkeley Law's International Human Rights Law Clinic and the Miller Institute for Global Challenges and the Law in conversation with Professor Justin Hansford (Howard) about his role as a member of the new UN Permanent Forum on People of African Descent.In the aftermath of the murder of George Floyd, in 2021 the United Nations established the Permanent Forum on Peoples of African Descent (PFPAD). This new, consultative body has a mandate to undertake a range of activities with the goal of “improving the safety and quality of life and livelihoods of people of African descent.” Professor Hansford shares his views about this new consultative mechanism, which addresses anti-Black racism as a UN platform, including its development, opportunities and challenges, and what was at stake in getting it approved and realized. He also examines reparations from a global and a US perspective, and discusses ideas for putting human rights strategy and practice into action in local marginalized communities.For a transcript of this episode, please visit the episode page on Berkeley Law website. Hosted on Acast. See acast.com/privacy for more information.
Nicholas Goldner, PhD, is the CEO and co-founder of resistanceBio, where he leads a mission to outsmart cancer by developing innovative therapies targeting treatment resistance mechanisms. He also serves as a venture partner at Pioneer Fund, actively investing in and supporting early-stage founders solving complex problems with science and technology. With a distinguished academic background, including a PhD in Molecular Cell Biology from Washington University in St. Louis, Nicholas combines scientific expertise with entrepreneurial prowess to create impactful solutions for pressing health challenges. Newsletter sign up (new and exciting developments) https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join Over 321 books from 170 plus interviews over 5 years https://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ https://youtu.be/h-xQBKlgAoQ PODCAST INFO: The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKS Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH RSS: https://www.learningwithlowell.com/feed/podcast/ Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA Website: https://www.learningwithlowell.com/ Nicholas Goldner links https://www.linkedin.com/in/nicholas-goldner/ https://www.resistance.bio/ Timestamps 00:00 Introducing Nicholas Goldner and ResistanceBIO 00:30 Saving 600,000 people a year 01:30 ENCER models for pharma 04:30 Importance of ResistanceBIO to understanding cancer 05:40 Why cancer comes back / resistance mechanisms 07:30 Cure vs treatment 09:00 Cancer is natural 10:30 Full ResistanceBIO platform explained 14:55 Last 3 years of development 17:30 Knowing they were on the right path, supportive data, and deeper understanding 24:50 Business incentive and business model explained 28:30 Hiding cure for cancer myth 31:00 Diagnostic potential 32:30 Last things pharma is looking for from them 34:30 Confidence in targeting/ therapy 35:45 Platform helping understand why failures happen 38:00 Adding 10,000,000,000 years of life 40:20 Nerding out and coffee 41:20 Headache caffeine 41:55 Looking to hire - cell culture scientist work 43:55 Key experiences that will translate into the role 45:55 Cellular agriculture / specialization 48:10 How do ENCER models differ from CRISPR, Organoids, and Animal models in terms of simulating resistance (FanQ) 54:30 What is left to do / what he needs help with 58:45 Immunotherapy and landscape change for cancer treatment and cure 01:01:40 Next 5 years and Lowell offers to chase Nick 01:03:50 Handling burnout and mental health 01:07:40 Art / being creative / painting 01:12:05 What books is he reading and what he recommends 01:14:23 Foundation apple tv show 01:15:10 Retirement for Nick 01:16:55 Police brutality episode https://www.youtube.com/watch?v=WgKBIb6Zb5c 01:17:40 Non resistance life
What do you know about whole body vibration for bone density? Curious? Skeptical? Me too. But with more and more instances of degeneration, chronic illness or long haul preventing the active life that supports bone health, additional means of stimulating both muscle and bone density are always on my mind. Falls are the second leading cause of unintentional death in the world. Older women are especially at risk due to decreased strength, reaction skills, balance, and low bone density. Falls result in fracture 31% percent of the time and 95% of hip fractures are the result of falls. For those who've had a prior fracture, they are twice as at risk for a future fracture. Whole body vibration (WBV) was first used by NASA with astronauts as a way to overcome the muscle and bone losses experienced by astronauts in space in the early 60s. Why the Need for Whole Body Vibration for Bone Density? Let me give a little background on why this is so problematic. Misinformed from perpetuating outdated information from both doctors and trainers (since 2015 evidence of not only increased safety and viability of high impact and high intensity exercise for osteoporotic postmenopausal women is much more promising than prior goals of stopping or slowing losses) 41% of women over 40 had either osteopenia (>31%) or osteoporosis (>14%) in a 2010 study Said differently, 31% of women over 40 had osteopenia and more than 30% of women over 60 had osteoporosis. The further from menopause (>10 years the increase in prevalence of osteoporosis = 40% compared to just 5 years post menopause at 9%) Whole body vibration increased BMD by 2% with 5 minutes 3x a week (for 6 mos) in postmenopausal women. In physically restricted individuals it's an alternative to other exercise. In able-bodied, in combination with resistance training, WBV increases results of both muscle and bone regeneration. While I wouldn't advocate only doing whole body vibration for bone density if you're able to do more, in conjunction with resistance training exercises, impact to your tolerance level, and attention to dietary and gut health, whole body vibration for bone density is an “extra” form of insurance. It not only improves bone density, but is beneficial to muscle, balance, and healing or regeneration in the case of injury. “Whole-body vibration therapy is an intentional biomechanical stimulation of the body using various frequencies of vibrations with the motive of health improvement. Ever since its discovery, this therapy has been extensively used in physiotherapeutic measures and the sports industry. For its property of increasing bone mass and density, space agencies use this therapy on astronauts who return to Earth after long-term space missions to regain lost bone and muscle mass. The potential of this therapy to restore bone mass encouraged researchers to look for its scope in the treatment of age-related bone degenerative diseases such as osteoporosis and sarcopenia, as well as in the correction of posture control and gait in geriatrics and post-menopausal women.” Mechanisms of Whole Body Vibration for Bone Density (and more) affects bone metabolism, muscle function, muscle training, and the endocrine system Vibration therapy provides anabolic mechanical signals to the bone and musculotendinous systems It improves blood circulation to the bones, ensuring an improved nutrition supply. Human adipose-derived stem cell differentiation into osteoblasts is facilitated by vibration therapy inhibiting excessive osteoclast formation improves bone health by amplifying gap junctional communication in osteocytes activate the tonic vibration reflex and induce non-voluntary muscular contraction activation of previously inactive muscle fibers enhances the endocrine system's functioning: Growth hormone increases What questions do you have about WBV for osteoporosis? References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139257/ https://pubmed.ncbi.nlm.nih.gov/36793830/ https://pubmed.ncbi.nlm.nih.gov/27331044/ https://www.hopkinsarthritis.org/arthritis-info/osteoporosis-info/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422949/#:~:text=Multiple%20factors%20are%20known%20to,fracture%20%5B18%E2%80%9320%5D. Other Episodes You Might Like: Exercise for Bone Density Then and Now: https://www.flippingfifty.com/exercise-for-bone-density/ 21 Reasons Weight Training Should Be Mandatory Exercise After 50: https://www.flippingfifty.com/weight-training-should-be-mandatory/
What if the universe, life, past lives, and reincarnations were much simpler than we think? What if we finally realize life is eternal, and we can do this again, and again, and again? Wouldn't that be utterly liberating? In this episode, I have the pleasure of presenting Dominic Zenden for the third time on the show. In this opportunity, our conversation goes even deeper. I appeal to Dominic's unique perspective to discuss the universe, soul-to-soul connections, UFOs, frequencies and vibrations, paranormal activities, poltergeists, and more. Dominic is an Aura Photographic Profiling expert, Author, Teacher, Public Speaker, and the host of Dial the Cosmos podcast. Throughout this episode, you'll learn if frequencies and vibrations have a match, Dominic's unique perspective on the universe, how things actually work around us, and why he believes paranormal activities aren't really paranormal. You'll also hear about mimic ghosts, poltergeists, soul memory, and soul-to-soul communications. Additionally, Dominic shares his thoughts on angels and ascended masters, UFOs' presence in mainstream media in the last couple of months, mediumship, and a lot more. Tune in to Episode 180 of Uncover Your Magic and let yourself be taken away by Dominic's wisdom and healthy habit of gifting us tons of food for thought. In This Episode, You Will Learn:Should deep connections with strangers be that rare? (7:50)Why Dominic believes the universe is way simpler than we think (18:50)What makes poltergeist scary (33:50)Soul memory and soul-to-soul communications. Do our organs have memory? (46:50)We do not choose our time of passing; we contribute to it (55:50)Connect with Dominic:WebsiteListen to Dial the Cosmos podcastEmail: email@example.comLet's Connect!WebsiteFacebookInstagramKeywords: Aura Photographic Profiling - Paranormal Activities - Life Is Eternal Hosted on Acast. See acast.com/privacy for more information.
Today on the Life Science Success podcast, my guest is Oksana Bovt. Oksana is the founder of Theoria Creative, an agency that develops unique fundraising materials that enable biotech and life sciences clients to clearly and succinctly articulate their unique message and value when raising funds, soliciting partnerships, pitching at roadshows, or presenting to prospective buyers. Oksana was a previous guest, and we covered her company and, more broadly, the things Theoria Creative is working on. Today we are going to spend some time on scientific mechanisms of action. Theoria Creative's Role: Oksana explains that her agency helps companies build a compelling story to attract investment. They work closely with venture capitalists and investment bankers. Challenges and Milestones: Oksana shares her journey and the importance of pivoting and sensing industry needs. Feedback from clients helps them stay relevant. Client Focus: Theoria Creative mainly focuses on late preclinical and early clinical companies that are in constant need of fundraising. Mechanisms of Action (MOA): Oksana discusses the importance of clearly explaining the scientific mechanisms of action (MOA) to differentiate one company from another. Communication Strategies: Oksana outlines three steps for companies to clearly communicate their MOA: Outline the step-by-step process. Write a descriptive paragraph for each step. Compare the mechanism with the healthy and unhealthy state. Materials and Outputs: Theoria Creative produces pitch decks and animations, depending on the client's budget and stage. Closing Remarks: Both Don and Oksana emphasize the importance of clear communication in the life sciences sector for successful fundraising and partnerships. This episode provides valuable insights into the importance of clear communication and storytelling in the life sciences sector, especially when it comes to explaining complex scientific mechanisms. Oksana's expertise in this area offers a roadmap for companies looking to articulate their value proposition effectively.
An elderly client has severe back and hip pain as she recovers from her second bout with COVID. Her doctor gave her a steroid shot, but her MT wonders if the pain is a post-viral form of myalgia. Join us in this episode of “I Have a Client Who . . .” as we look at some research about post-COVID musculoskeletal pain and the many mechanisms involved (and host Ruth Werner throws a short tantrum about a narrowly focused study that misses some important factors). Sponsors: Books of Discovery: www.booksofdiscovery.com Host Bio: Ruth Werner is a former massage therapist, a writer, and an NCBTMB-approved continuing education provider. She wrote A Massage Therapist's Guide to Pathology, now in its seventh edition, which is used in massage schools worldwide. Werner is also a long-time Massage & Bodywork columnist, most notably of the Pathology Perspectives column. Werner is also ABMP's partner on Pocket Pathology, a web-based app and quick reference program that puts key information for nearly 200 common pathologies at your fingertips. Werner's books are available at www.booksofdiscovery.com. And more information about her is available at www.ruthwerner.com. Recent Articles by Ruth: “Working with Invisible Pain,” Massage & Bodywork magazine, November/December 2022, page 36, http://www.massageandbodyworkdigital.com/i/1481961-november-december-2022/38 “Unpacking the Long Haul,” Massage & Bodywork magazine, January/February 2022, page 35, www.massageandbodyworkdigital.com/i/1439667-january-february-2022/36. “Chemotherapy-Induced Peripheral Neuropathy and Massage Therapy,” Massage & Bodywork magazine, September/October 2021, page 33, http://www.massageandbodyworkdigital.com/i/1402696-september-october-2021/34. “Pharmacology Basics for Massage Therapists,” Massage & Bodywork magazine, July/August 2021, page 32, www.massageandbodyworkdigital.com/i/1384577-july-august-2021/34. Resources: Pocket Pathology: https://www.abmp.com/abmp-pocket-pathology-app Alnamlah, O.S. and Almarwani, M.M. (2023) ‘Musculoskeletal pain post-COVID-19 in patients undergoing physical therapy in Saudi Arabia: a cross-sectional study', BMC Musculoskeletal Disorders, 24, p. 507. Available at: https://doi.org/10.1186/s12891-023-06647-9. Cevei, M. et al. (2022) ‘Rehabilitation of Post-COVID-19 Musculoskeletal Sequelae in Geriatric Patients: A Case Series Study', International Journal of Environmental Research and Public Health, 19(22), p. 15350. Available at: https://doi.org/10.3390/ijerph192215350. Khoja, O. et al. (2022) ‘Clinical Characteristics and Mechanisms of Musculoskeletal Pain in Long COVID', Journal of Pain Research, 15, pp. 1729–1748. Available at: https://doi.org/10.2147/JPR.S365026. Tiwari, V. and Bergman, M.J. (2023) ‘Viral Arthritis', in StatPearls. Treasure Island (FL): StatPearls Publishing. Available at: http://www.ncbi.nlm.nih.gov/books/NBK531507/ (Accessed: 18 September 2023). My articles on COVID and massage: Massage & Bodywork - JANUARY | FEBRUARY 2022 (no date). Available at: https://www.massageandbodyworkdigital.com/i/1439667-january-february-2022/36? (Accessed: 20 September 2023). Massage & Bodywork - SEPTEMBER | OCTOBER 2020 (no date). Available at: https://www.massageandbodyworkdigital.com/i/1276187-september-october-2020/46? (Accessed: 20 September 2023).
This is part 2 of our 2-part episode with Dr. Christopher Lowry, a professor of Integrative Physiology, Psychology, and Neuroscience, specializing in the gut microbiome. If you haven't listened to the first half of this interview, we recommend starting there first. His research program at CU Boulder focuses on understanding stress-related physiology and behavior, emphasizing the microbiome-gut-brain axis. His research is designed to lead to novel, microbiome-based interventions for preventing anxiety, mood, and trauma- and stressor-related disorders, such as posttraumatic stress disorder (PTSD). In this half of our interview with him, we'll talk more about his work there, as well as practical ways to improve your gut health and the potential implications for that when it comes to better resilience under stress. More about Dr. Lowry: https://www.colorado.edu/iphy/people/faculty/christopher-lowryDr. Lowry's TedX talk: Plants, the Microbiome, and Mental HealthTimestamps:00:00:22 Who is Dr. Chris Lowry00:01:10 Gut Biome, Immune System, and Mental Health00:05:51 Mechanisms at Work00:08:06 Working With Certain Strains With Veterans00:10:38 TBI and PTSD00:12:18 Neurotransmitters in the Gut00:18:01 Mitigate Damage From Bad Eating Habits00:22:42 Ayahuasca and PTSD00:24:33 Two Hit Model of Stress Exposure00:27:55 Long Covid and Neuroinflammation00:33:38 Lower Inflammatory Response 00:34:22 Learn More About Dr. Chris Lowry's Work00:35:15 Outro
Vacations are over and the kids are back at school. It's that time of year when we often feel the need to get “back on track” and into the structure and routines that help us thrive. But something that we rarely consider is that as life changes, so does our personal “recipe for success.” Be it in relationships, careers, added responsibilities, shifting hormones, or the ages of your kids, life has a way of changing and throwing curve balls when it comes to maintaining a healthy routine. So if you're looking to establish some new habits around sleep, food, movement, mental health, unhealthy coping mechanisms (or any other area of positive change), this episode is the perfect place to start. With the tips you gather here, you'll be able to evaluate all the variables in your life at this moment so you can create habits and routines that are both achievable and supportive of your body's needs. In this episode, you'll learn: Why we have to consider our season of life as we build new habits How one area of change can easily fuel change in other areas of your health Why letting habits go can be just as powerful as adding habits in How to break down your habits into achievable tasks The impact of journaling about the change you want to see in yourself To connect with Wendy about her coaching and programming, visit: https://www.wendymccallum.com/
This week, the UN General Assembly will meet in New York to discuss, among other things, international cooperation to improve global cyber security challenges. This meeting builds on national and international commitments and initiatives that have already been made this past year. One such initiative is cyber-secure nations banding together to provide aid to cyber-risk nations.Lawfare Legal Fellow Saraphin Dhanani sat down with Eugenia Lostri, Lawfare's Fellow in Technology Policy and Law, who recently wrote an article titled, “What Will Mechanisms for Cybersecurity Aid Look Like?” They discussed why cybersecurity aid is necessary, the growing initiatives that the U.S., EU, and international bodies are making in this area, and the many challenges that await.Support this show http://supporter.acast.com/lawfare. Hosted on Acast. See acast.com/privacy for more information.
Can you live a longer, healthier life without sacrificing the things you enjoy doing?This episode's guest is Thomas DeLauer, a nutrition and business performance coach with over 3.5 million subscribers on YouTube. Thomas built his name around helping busy people live longer, healthier, and happier lives by making small diet and lifestyle changes. In this episode, Thomas and I discuss:Longevity and the keys to slowing down agingThe habits linked to a longer, healthier lifeHormetic stressors and why they're importantWhat the science says about calorie restrictionThe benefits of heat and cold therapiesThe role of FOX03 for longevity[00:00] Introduction[00:28] Thomas' Understanding of Aging[02:27] Why Aging is Not Necessarily About Living Longer [05:07] What are HDACs?[09:25] How to Express and Activate Your Genes[12:35] Good Sleep For Health and Wellnes[14:20] The Science of Longevity Through a HDAC Lense[16:16] Sunlight and Other HDAC Inhibitors[20:43] Understanding Hormesis and Hormetic Stressors[25:26] How a Good Amount of Stress Affects Longevity[28:57] Thoughts on FOX03[32:15] Is Calorie Restriction the Answer to Longevity?[34:20] Intermittent Vs Prolonged Vs Controlled Fasting[39:45] Thomas' Thoughts on Meat and Plant-Based Diets[43:33] Heat Therapy: Benefits and Types[48:26] Mechanisms and Efficacy of Heat and Cold Therapies[51:52] Thomas' Love For the Sauna [53:47] Is Sex Important For Longevity and Healthspan? [56:16] Parting Thoughts Optimise your health with InsideTracker's biomarker analysis. Get exclusive access to InsideTracker's new ApoB test, and a significant discount at http://insidetracker.com/louisaOptimise your hydration and get a free sample pack of electrolytes at http://drinklmnt.com/neuroLinks and Resources:Thomas on Instagram: https://www.instagram.com/ThomasDeLauer/Thomas' YouTube Channel: https://www.youtube.com/user/TheTdelauer/videosWebsite: https://thomasdelauer.comThe Neuro Athletics Newsletter Instagram: louisanicola_Twitter : louisanicola_YouTube: Louisa Nicola
Are you ready to unravel the complexities of the financial world? This episode promises to serve you a rich feast of insights as we are joined by Daniel DiMartino Booth, a former advisor to the Federal Reserve, and Joseph Wang, an experienced trader. They lend us their expert lens to examine the Federal Reserve's influence on the bond market, the shifting structure of fixed income markets, and the implications of credit spreads. Joseph's trading anecdotes brilliantly illuminate the importance of comprehending the financial system, while Daniel's admiration for Fed chair Jay Powell validates the profound impact of regulations and ETFs on fixed income markets.We are not stopping just there! As our financial expedition continues, we delve into the potential aftereffects of the Fed's quantitative tightening strategy, and what a treasury-only portfolio might mean. Our guests expertly navigate us through the possible economic waves that a soaring dollar could trigger, particularly on emerging markets. They draw our attention towards the Fed's careful observation of markets beyond headline averages and how wealth effect dynamics, inflation, and consumer spending play crucial roles.Our conversation takes an exciting turn as we scrutinize jobless claims data, the impacts of escalating delinquencies, and the stock market. We also aim our spotlight on the global financial system, dissecting potential risks from smaller banks' loan concentration. Daniel and Joseph help us comprehend the ECB's role in providing stimulus and the repercussions of bond market and inflation on the US economy. Wrapping up our chat, we reflect on France's economic slowdown, the US fiscal policy, and the tidal shift towards increased government spending. This episode is surely an enlightening journey into the world of finance, promising to leave you with a broader understanding of these intricate topics.ANTICIPATE STOCK MARKET CRASHES, CORRECTIONS, AND BEAR MARKETS WITH AWARD WINNING RESEARCH. Sign up for The Lead-Lag Report at https://theleadlag.report/leadlaglive and get 30% off as a podcast listener.Nothing on this channel should be considered as personalized financial advice or a solicitation to buy or sell any securities. The content in this program is for informational purposes only. You should not construe any information or other material as investment, financial, tax, or other advice. The views expressed by the participants are solely their own. A participant may have taken or recommended any investment position discussed, but may close such position or alter its recommendation at any time without notice. Nothing contained in this program constitutes a solicitation, recommendation, endorsement, or offer to buy or sell any securities or other financial instruments in any jurisdiction. Please consult your own investment or financial advisor for advice related to all investment decisions.Uranium Spotlight: Nuclear's Resurgence in a Clean Energy WorldA weekly podcast on uranium fuel market trends and its global energy impactListen on: Apple Podcasts SpotifyFoodies unite…with HowUdish!It's social media with a secret sauce: FOOD! The world's first network for food enthusiasts. HowUdish connects foodies across the world!Share kitchen tips and recipe hacks. Discover hidden gem food joints and street food. Find foodies like you, connect, chat and organize meet-ups!HowUdish makes it simple to connect through food anywhere in the world.So, how do YOU dish? Download HowUdish on the Apple App Store today:
The Life Lessons podcast has a simple mission: to have discussions that reveal something important about life and how best to live it. My guests range from the biggest sporting names on the planet, as well as neuroscientists, world-renowned philosophers, and psychologists – right through to Buddhist monks.We all have psychological defence mechanisms - including the often deep-seated pattern of projection. Mike Brearle - one of the greatest sporting leaders of all-time turned psychoanalyst - explains what it is, why we do it and shares some rather well-known examples.YouTube: https://tinyurl.com/YouTubeSimonMundieInstagram: https://www.instagram.com/simonmundie/For the 'Mundie on Monday' newsletter - head to simonmundie.com Please do share this episode - it makes a big difference in helping people find this podcast.Thank you. Hosted on Acast. See acast.com/privacy for more information.
Hear, O Cabalists! The noble Lords of the Dungeon return to regale thee with tales of roleplay anew. Today, we embark upon a quest into the mystical realms of Talespire, a 3D tabletop conjuration that doth defy imagination's bounds. Then our gaze falls upon three RPG gems, rare as phoenix feathers, bearing unique mechanisms: Ten Candles, Dread, and Alice is Missing. And in the shadows of discourse, we unfurl the cloak of suspension of disbelief, where the ethereal dance of fantasy and reality unfolds in the realm of roleplay. Join us on this lyrical odyssey, as the Lords of the Dungeon beckon thee to a world where stories breathe and dreams take flight!
There's a very pervasive social narrative that moms need alcohol in order to survive motherhood. This is what is known as “mommy wine culture” and chances are, you're all too familiar with this messaging because the marketing behind it is really unavoidable. On this episode, I'm joined by life coach and author of It's Not About the Wine, Celeste Yvonne to help us uncover the real reasons moms want to escape and why alcohol as a coping mechanism is just adding to the mayhem. We will talk about the challenges for mothers returning to the workforce, the insane lack of postpartum support, and the pressure to regularly achieve impossible parenting standards. But we're not just exposing the problem. Celeste gives us some practical advice for how to start redistributing the mental load with your partner or support system and why being active in a sober community can transform your perspective on motherhood. In this episode, you'll learn Why it's important to get curious about your defensiveness about drinking The moment that Celeste learned she didn't have to gaslight herself any longer Why the pressure to enjoy every moment of motherhood is unsustainable The first step to take towards redistributing the division of labor in your home Why you don't have to identify as an “alcoholic” (or hit rock bottom) before you get curious about your relationship with alcohol To learn more about Celeste and her work, connect with her on her website at https://www.celesteyvonne.com, or follow her on Instagram @theultimatemomchallenge. Be sure to grab her book, It's Not About the Wine- which is available now! To connect with Wendy about her coaching and programming, visit: https://www.wendymccallum.com/
Guest host, Sarah Shipp, talks about the concept of resonance when designing games, SUCCESS (from "Made to Stick" by Chip & Dan Heath), and Sarah's own equation for resonance: Familiary + Unexpectedness - Chaff Also, see Sarah's GDC talk on Creating Resonance with Thematic Design available here: https://www.youtube.com/watch?v=61YNkTv3xgM
Join us for a deep dive into the molecular science of anti aging with the brilliant mind behind the innovative brand MDAiRE , Dr Stefani Kappel MD. This episode focuses on the uniquely intricate science of aging down to the major molecular pathways involved including those targeted by the MDAiRE range of products. Dr Kappel talks to us all about the details of ARE and how she utilized the details of understanding its mechanism of action while creating her incredibly efficacious brand. ARE is an acronym for an important signal transduction pathway in the skin. It stands for the Antioxidant Response Element (ARE). The “i” in science represents “the induction of". Hence AIRE represents the activation of this powerful anti-aging pathway. Inducing this key anti-aging pathway results in the transcription and translation of protective genes that play a major role in the anti-aging process. Activation of the AIRE pathway protects skin cells from oxidative stress which remains one of the best etiologies to explain the mechanism of aging. Dr. Kappel is a board certified, and double fellowship trained Dermatologist and Mohs Micrographic Surgeon with an active practice in Newport Beach California. She has over 15 years of experience in practicing Dermatology and studying the skin. She has a Medical Degree from UC Irvine and completed her residency in Dermatology at UCLA. Upon completing her residency, she joined the full-time faculty at UCLA as a Clinical Instructor and Professor in Dermatology and Dermatologic Surgery. She then went on to complete advanced fellowship training in Dermatologic Surgery at UC Davis and Cosmetic Dermatology at the Laser and Skin Surgery Center of Northern California with world-renowned expert, Dr. Suzanne Kilmer. After fellowship, she was appointed the Director of Dermatologic Surgery at the Laser & Skin Surgery Center of Northern California where she has remained active in clinical trials and has been on the forefront of the latest advances in aesthetics and dermatology.Support the showFollow The Show On All Socials Using The Tag @skincareanarchy