Podcasts about mechanisms

Jesus is the Light who steps into real darkness—brokenness, shame, anxiety, and the “copes” we reach for when life hurts. In John 1 and John 8, we see a Saviour who refuses condemnation and instead offers grace, truth, and a new way to live. This Christmas, let's follow the Light and become lights—bringing hope into homes, parties, and everyday moments.

Nutrients are usually studied in isolation, yet synapses don't operate that way. This episode examines research showing that coordinated nutritional inputs can reshape synaptic proteins and neural firing patterns (effects that isolated inputs fail to produce). The shift isn't about stronger signaling, but more organized signaling within brain circuits.The goal: explain why biological systems respond to combinations rather than singles, how coordinated inputs influence synaptic receptors, protein synthesis, and network synchronization.00:00 Introduction to Neural Circuit Malfunctions00:39 Understanding Neural Communication01:38 Nutrient Interventions in Neural Circuits02:57 Research Findings on Nutrient Mixtures04:37 Mechanisms of the Mixture06:33 Practical Implications and Dietary Recommendations09:01 Conclusion and Final ThoughtsPMID: 41329641PMID: 38498094PMID: 40910091

In this episode, host Ellie Woodacre interviews the editor of the cluster ‘Diplomacy as Performative Politics in the Early Modern Courts', as featured in the December 2025 issue of the Royal Studies Journal (issue 12.2). We discuss the inspiration behind this theme and delve into the contents of the cluster and its original and innovative approach to early modern diplomacy, rulership and courts. Guest Bio/Info:Dr Kristen Vitale Engel is an early modern historian who specializes in the early Tudor state, performative politics, and late medieval and early modern European court culture. She successfully defended her doctoral dissertation (thesis), titled “Henrician Spectacle: Courtly Festivity as Performative Politics in Early Tudor England, 1485-1533” in April 2025 at the University of Connecticut. She is a Visiting Assistant Professor of History in the School of Graduate, Online and Continuing Education at Fitchburg State University. Kristen is the Submissions Editor for the Royal Studies Journal, the Editor-in-Chief of “The Court Observer” for the Society of Court Studies, the International Ambassador (US) for HistoryLab+ in partnership with the Institute of Historical Research, a podcast host for the “Early Modern History” channel on the New Books Network, and an Associate Fellow of the Royal Historical Society. Forthcoming publication of interest: “The Performance of Power Relations: Early Henrician Courtly Dance,” in eds., Janet Dickinson and Diana Lucia Gomez-Chacon, The Embodied Court in the Premodern World; Understanding the Physicality, Performativity and Lifecycle of Bodies at Court in Europe and Beyond, 1400-1800, in series Courts and Courtiers in a Global Context Comparative Approaches to the Study of the Mechanisms and Personalities of Pre-Modern Court Cultures, vol. 4, Brepols, 2026. Follow Kristen on  X: @kristenmvitale

PREVIEW — Andrea Stricker — Nuclear Safeguards Framework for Saudi Arabia's Reactor Acquisition. Strickeroutlines essential precautions and international safeguard mechanisms necessary to prevent nuclear proliferation resulting from Saudi Arabia's acquisition of advanced nuclear power plant technology and fuel cycle capabilities. Strickerrecommends permanent International Atomic Energy Agency (IAEA) safeguard protocols and comprehensive additional verification arrangements covering all present and future Saudi nuclear facilities, ensuring Riyadh cannot unilaterally eject IAEA inspectors or rescind international safeguard commitments if the Kingdom subsequently pursues uranium enrichment or nuclear fuel reprocessing activities for weapons development. Stricker emphasizes that binding safeguard protocols are essential to preventing Saudi acquisition of weapons-grade nuclear material and maintaining nonproliferation regime integrity in the Middle East.

Historically, key symptoms of primary biliary cholangitis (PBC), such as pruritus and fatigue, have been understudied and undertreated. Listen now to learn how symptom management should be considered independently of PBC management, and how new therapeutic agents can help.Topics covered include:Mechanisms of pruritus and fatigue in PBCNonpharmacologic treatment optionsAn overview of clinical trial data supporting second-line agents for symptom management:BezafibrateElafibranorSeladelparInvestigational agents:VolixibatLinerixibatSetanaxibThis episode is the third of 3 recap podcasts, featuring audio from our live satellite symposium, Raising the Bar: Innovations in PBC Care. For the full on-demand webcast of this satellite symposium, and to download the accompanying slides, visit the program page for this episode:https://bit.ly/44ZJ5osPresenters:Christopher L. Bowlus, MDLena Valente Professor and ChiefDivision of Gastroenterology and HepatologySchool of MedicineUniversity of California DavisSacramento, CaliforniaAparna Goel, MDClinical Associate Professor of MedicineDivision of Gastroenterology and HepatologyStanford UniversityPalo Alto, CaliforniaAliya F. Gulamhusein, MD, MPH, FRCPCProfessorship in PSC ResearchClinician Investigator, Toronto General HospitalAssistant Professor, University of TorontoDivision of Gastroenterology and HepatologyUniversity Health NetworkToronto, CanadaGet access to all of our new episodes by subscribing to the Decera Clinical Education Medical Specialties Podcast on Apple Podcasts, YouTube Music, or Spotify. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Interview with Alfred E. Buxton, MD, and Marie-France Poulin, MD, authors of Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement. Hosted by Kristen K. Patton, MD. Related Content: Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement

Interview with Alfred E. Buxton, MD, and Marie-France Poulin, MD, authors of Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement. Hosted by Kristen K. Patton, MD. Related Content: Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement

Welcome back to the Flex Diet Podcast! Today, I'm hanging out with the brilliant Katie Emerson, Senior Manager of Scientific Affairs over at Kyowa Hakko USA, aka the people behind Cognizin (CDP Choline), one of the few brain-boosting ingredients with legit research behind it.We dig into the real science of CDP Choline, how it supports memory, focus, and cognitive performance, and where it actually fits into the human physiology engine, not the hype machine. Katie and I also zoom out into the supplement industry as a whole, chatting about what's worth paying attention to, what's still emerging, and how to navigate all the shiny promises out there.We even take a nerd-tour into mental resilience, genetic mapping, and the surprising potential of glutathione for health and performance.If you're curious how targeted supplements can help you think faster, recover better, and be a more high-performing human without needing a PhD to decode marketing nonsense, this episode is for you.Sponsors:Flex 4: Katie's top 4 things to know about citocholineEpisode Chapters:03:52 Katie Emerson Joins the Conversation04:09 Conversations at ISSN and Networking11:20 Research and Studies on CDP Choline17:49 Challenges in Supplement Formulation24:40 Mechanisms and Benefits of CDP Choline28:06 Exploring Genetic Mapping and Data Overload29:01 Study Design and Dosing Strategies30:29 The Sweet Spot of CDP Choline Dosage33:40 Pharmacokinetics and Timing of CDP Choline35:36 Safety and Side Effects of High Doses38:59 Comparing CDP Choline and Alpha GPC42:41 Introduction to Glutathione48:41 Oral Absorption of Glutathione52:12 Podcast Conclusion and Listener Information Episodes You Might Enjoy:Episode 343: Fueling the Corporate Athlete: Stress, Supplements & Performance with Dan Hunter YouTube: https://youtu.be/0ek4XSs62RQ Episode 222: Expert Insights on nutrition, supplements, and training with Registered Dietitian Sean CaseyYouTube: https://youtu.be/wjJB-y1kwgMConnect with Katie:Cognizin: cognizin.comGet In Touch:Instagram: https://www.instagram.com/drmiketnelson/YouTube: https://www.youtube.com/channel/UCn1aTbQqHglfNrENPm0GTpgEmail: https://miketnelson.com/contact-us/

Coach Bronson discusses his journey into ketogenic research, emphasizing the importance of understanding metabolic flexibility and the biases present in current studies. He highlights common misinterpretations in research, particularly regarding oxygen consumption and the duration of ketogenic interventions. Bronson also addresses the challenges of washout periods in studies, the significance of electrolyte balance, and the misuse of mechanisms to justify carbohydrate superiority. The discussion aims to provide listeners with a clearer understanding of ketogenic diets and the need for more rigorous research methodologies.Chapters00:00 Introduction and Background02:14 The Evolution of Ketogenic Research05:49 Identifying Biases in Nutritional Studies10:50 Misinterpretation of Oxygen Consumption14:43 Understanding Movement Economy29:36 Challenges in Defining Ketogenic Adaptation39:41 The Problem with Washout Periods44:10 The Loss of Curiosity in Nutrition Science45:55 Reanalyzing Existing Data in Nutrition49:01 Physiological Resilience and Athletic Performance52:06 The Importance of Study Duration in Research53:58 Performance Claims vs. Actual Data56:50 Misinterpretation of Ketogenic Diet Studies01:01:01 The Role of Electrolytes in Low-Carb Diets01:12:00 Mechanisms of Carbohydrate Superiority

PREVIEW — David Daoud — Hezbollah's Ideological Bond and Financial Secrecy. Daoud explains that Hezbollah'sfinancial structures remain systematically opaque and untraceable, as the organization utilizes clandestine fundraising mechanisms and independent revenue streams rather than relying exclusively upon Iranian material support and financial transfers. Daoud characterizes the "genius" of the Hezbollah-Iran relationship as fundamentally ideological rather than transactional; Hezbollah maintains unwavering loyalty to Tehran rooted in shared religious conviction and revolutionary philosophy, meaning the organization would remain strategically faithful to Iran even if material support and financial subsidies were terminated, creating durable strategic partnership independent of fluctuating resource availability. 1960 BEIRUT

Sen and Erica welcome Sarah Shipp, guest host of Thinking Beyond Mechanisms, to talk about some of the ways in which theme can be measured and how that affects game design.

Drew Perkins welcomes neuroscientist and acclaimed author Jared Cooney Horvath to dissect his new book, The Digital Delusion, which provides a rigorous, evidence-based critique of edtech. Links & Resources Mentioned In This Episode Horvath doesn't mince words, arguing that the majority of student-facing, internet-connected devices should be removed from schools. He reveals that over 60 years of consistent data supports his claim that the integration of digital tools is fundamentally detrimental to effective learning. This isn't a Luddite's complaint; it's a detailed exploration of the Neuroscience of Learning. The harm is explained through three primary biological mechanisms, which Horvath asserts are unfixable with software. First, screens train students to multitask, leading to a constant, detrimental battle for attention in a learning environment. Second, the use of devices inhibits the essential human-to-human interaction necessary for empathetic synchrony—the mirroring and mimicking critical for deep cognitive and social development. Finally, we discuss the profound problem of Transfer of Learning. Horvath explains that by learning skills in an "easy" digital context, the ability to transfer that knowledge to a more complex, real-life (analog) task is significantly diminished, making the learning "slower, worse, and less deep." The data suggests tech only works in highly narrow contexts, primarily for surface-level "drill and kill" facts or basic remediation, often through intelligent tutors. The conversation then shifts to the persistent educational conflicts, notably the ongoing tension between Explicit Instruction vs Inquiry and Project-Based Learning (PBL). Horvath connects the rigidity of entrenched positions to a "sunk cost" phenomenon, where individuals find it too "costly" to change their public stance, even when facing opposing evidence. We delve into the complexities of teaching, noting that both traditional and progressive approaches are valid at different points in a student's journey, but both are fundamentally flawed when they adhere rigidly to a single philosophy. Furthermore, we explore the nature of Critical Thinking Skills and creativity. Horvath clarifies that while the mechanism for critical thinking is innate across all ages, its output is heavily constrained by the individual's available domain-specific knowledge. The science of learning, he argues, has nothing to say about specific pedagogy (such as direct instruction versus exploratory learning); it only describes the biological constraints of how the brain learns. Therefore, neuroscience should serve as a powerful tool to inform and improve any existing pedagogical approach, not dictate a single one. Horvath offers a vision for the ideal classroom, suggesting elementary spaces should be "basically outdoor," focused on play and minimal tech. For older students, he advocates for a high level of control, confining computer use to specialized lab settings—much like woodshop or physical education. This perspective provides an essential counter-narrative for any K-12 educator or administrator struggling to balance modern tools with effective, long-term student success. To continue exploring innovative, evidence-based strategies, subscribe to the ThoughtStretchers Podcast on your favorite podcast player! Timestamped Episode Timeline Time Segment/Topic [00:00] Introduction of Jared Cooney Horvath – Teacher-turned-neuroscientist, focus on "human learning" and applying neuroscience to educational practices. [01:28] Jared's Educational Background and Views on Pedagogy – Describing his K-12 experience as a "mishmash" that didn't adhere rigidly to "traditional" or "progressive" labels. [03:45] The Digital Delusion Book & EdTech Critique – Introducing the book and its core argument: edtech fundamentally harms learning, advocating for reducing/eliminating non-essential computer use in classrooms. [07:18] EdTech and Learning Outcomes/The Swedish Example – Advocating for removing student-facing, internet-connected devices; citing Sweden's ban on general tech use in schools (confining computers to a lab). [08:09] Exceptions for Technology Use – Tech only works effectively in narrow contexts: self-adaptive "intelligent tutors" for surface-level (drill and kill) learning and remediation. [09:46] Mechanisms of EdTech Harm (Biological) – Outlining the three primary ways screens harm learning: Attention, Empathetic Synchrony, and Transfer. [12:29] Transfer and Complexity in Learning – Discussion on how learning in an easy digital context makes skill transfer to a harder, real-life analog context almost impossible. [15:54] AI, Pedagogy, and Creating Learning Tools – Drew's example of using AI for quizzes; Jared's counter that learning is "slower, worse, and less deep" than if the student created the tools themselves. [18:07] The Ideal Classroom – Jared's vision for elementary (outdoor, play-focused, minimal tech) and middle/high school (human-element focus, highly controlled tech use in a lab). [20:17] Critical Thinking and Metacognition – Discussion on the definition of critical thinking, with Jared suggesting metacognition is a more accurate term for the process. [23:02] The Role of Knowledge in Critical Thinking – The mechanism is universal, but the outcome of critical thinking without knowledge is "very very narrow or pointless." [27:43] Creativity and Questioning – Defining creativity as "rearranging of your current memory structures." The role of knowledge and safety/context in the ability to ask good questions. [35:47] Tension Between Traditional and Progressive Education – Observing the acute conflict in Australia/UK; asserting both approaches are correct at different points but wrong when they are too rigid. [40:34] Science of Learning and Pedagogy – Stressing that the science of learning only concerns biological mechanisms and should inform teaching, not dictate a specific pedagogy. [43:08] AI Model Training and Pedagogical Parallels – Drew's question on parallels between AI's "symbolism" vs. "connectivism" and educational philosophies. [44:15] Critique of AI and Cognitive Models – Jared's view that AI conceptualization has mistakenly influenced brain understanding and that current AI models may be at a peak without a new theoretical framework. [46:02] Book and Contact Information – Sharing website (www.lmegglobal.net), new book (The Digital Delusion), and YouTube channel. [46:47] Closing Remarks – Final thoughts on recognizing the "gray zone" in complex educational issues.  

In this video Louise offers a simple practice for connecting with your inner guidance.• Join Louise for a live guided meditation followed by Q&A on Zoom every Saturday and Sunday (by donation): https://www.louisekay.net/zoom.html • Upcoming In-person Retreats:https://www.louisekay.net/retreats.htmlLouise Kay holds group events and retreats online and around the world.For more details visit http://www.louisekay.net/

PREVIEW — Mary Anastasia O'Grady — Lingering Capital Controls Spook Investors in Argentina. O'Grady reports that despite President Milei's substantial deregulation initiatives, lingering Argentine capital control mechanisms continue systematically deterring foreign investors who harbor justified fears regarding restrictions on capital extraction and currency repatriation. O'Grady documents that previous Argentine administrations implemented draconian capital restrictions, deploying customs enforcement mechanisms including canine detection units on Uruguayan river ferries to prevent illegal capital flight. O'Grady emphasizes that investor communities remain chronically cautious regarding potential reimposition of capital controls by future political administrations, creating structural investor hesitation despite Milei's demonstrated commitment to economic liberalization and market-based reforms. 1950 TANGO IN BUENOS AIRES

In this episode of the Green Pill Podcast, Kevin Owocki and co-host Devansh Mehta sit down with Vitalik Buterin for their annual deep dive into the future of public goods funding in the Ethereum ecosystem. They explore where funding will come from in 2026, how the landscape has shifted from "vibes-based" funding to verifiable, dependency-driven mechanisms, and why this is the best moment to reform PGF using new tools like programmable cryptography, AI-assisted evaluation, and deep funding models. Vitalik also shares how he thinks about dependencies, credible neutrality, open-source licensing, pluralism, accountability, and what builders should prioritize in the coming year. A must-listen for anyone designing mechanisms, funding public goods, or building the next era of Ethereum governance.

Socialism Comes to New York — Cliff May — May critiques New York City Mayor-elect Momdani's socialist-oriented policies, arguing that aggressive rent freeze mechanisms systematically diminish housing stock availability, reduce construction incentives, and undermine long-term affordability through supply contraction. May warns that additional socialist initiatives including fare-free public transportation and police defunding drive middle-class residents toward suburban and exurban jurisdictions. May cites Venezuelan economic collapse and continuing socialism failure across multiple jurisdictions as empirical evidence that socialist economic models fundamentally cannot function effectively in complex modern capitalist economies like New York City. 1888 five points

3/4. Price Discovery, Trade Policy, and Government Market Distortions — Terry Anderson (Editor) — Andersondiscusses Timothy Fitzgerald's analysis demonstrating that border carbon adjustment mechanisms frequently disguise protectionist trade policies, aligning with the "bootleggers and Baptists" theoretical model. Anderson stresses that authentic price discovery in financial markets is absolutely crucial for effective climate adaptation. However, government intervention, including subsidized insurance programs for flood and crop losses, systematically distorts accurate price signals, preventing consumers from developing effective behavioral and economic adaptations to genuine environmental risks. 1905

Today, I am delighted to be joined by a friend and colleague, Mike Mutzel.  Mike has a master's in Clinical Nutrition from the University of Bridgeport. He is a graduate of the IFM, applies functional medicine in clinical practice, and is a consultant lecturer who teaches leading-edge science in a concise format for progressive clinicians to prevent chronic diseases.  In our discussion, Mike and I unpack the benefits of creatine monohydrate, highlighting the importance of ensuring the products we use are free of impurities. We explain how creatine monohydrate gets created, answer many listener questions, and describe current research specific to creatine monohydrate, discussing ways to support bone health, navigate dosing, and how to troubleshoot.  This conversation with Mike Mutzel is truly invaluable, and I look forward to having him back on the podcast to dive a little deeper into the science.  IN THIS EPISODE, YOU WILL LEARN: How creatine supports energy production across muscles, the brain, and other organ systems Why vegetarians and vegans should take creatine What to consider when choosing high-quality creatine supplements Dosing strategies based on diet, exercise, sleep, and individual needs How taking creatine with electrolytes while exercising can improve absorption Benefits of supplementing with amino acids alongside creatine for illness, recovery, or when protein intake is low Adjusting your creatine dosage for sleep, travel, or exercise demands How creatine supports bone and muscle health  The value of creatine for the eyes and ears Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Mike Mutzel On his website YouTube Instagram High Intensity Health Podcast Creatine Research: Creatine in Women's Health: Bridging the Gap From Menstruation Through Pregnancy to Menopause Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial

Jamie and Don, freshly back from PAX Unplugged 2025 in Philadelphia, have been getting into some board, card, and dice rumbles lately, and they wanted to dig into the many styles of combat systems in board games. Deterministic versus random, complex versus streamlined, dice versus cards - there's a lot of ground to cover. Also, our yearly fundraiser is currently running on Kickstarter! Support us now at https://www.thesecretcabal.com/kickstarter

Join Ryan K. Shields, PharmD, MS, in the third of 3 podcasts from our live event, “The Plot (and Sputum) Thickens: Encountering Carbapenem Resistance in Critically Ill Patients” to learn how to optimize antimicrobial regimens and develop evidence-based antibiotic management plans for complex infections caused by carbapenem-resistant bacteria. Topics covered in this segment include:Mechanisms of resistance in S. maltophiliaCurrent frontline therapies2024 IDSA guidance for treatmentPresenter:Ryan K. Shields, PharmD, MS Associate Professor of MedicineCo-Director, Center for Innovative Antimicrobial TherapyUniversity of PittsburghCo-Director, Antibiotic Management ProgramUPMC Presbyterian HospitalPittsburgh, PennsylvaniaLink to full program and downloadable slides:https://bit.ly/3JWaqRvGet access to all of our new podcasts by subscribing to the Decera Clinical Education Infectious Disease Podcast on Apple Podcasts, Google Podcasts, or Spotify.   Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

4/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1918

3/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1916

2/8 Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul. 1917

1/8. Autocrats Versus Democrats: China, Russia, America, and the New Global Disorder. Michael McFaul analyzes the Cold War, noting that the Cuban Missile Crisis taught the need for crisis management mechanisms with adversaries. He argues that the US was too complacent, first when engaging China after Tiananmen Square without stressing values, and later when failing to invest politically and economically to consolidate democracy in post-Soviet Russia. Guest: Michael McFaul 1812.

Turn online alignment into an offline community — join us at TheWayFwrd.com to connect with like-minded people near you.Your symptoms aren't random, they're the crime scene of a moment your mind forgot.In this episode, I sit down with Dr. Melissa Sell to explore a biological map born from one doctor's grief, and how sudden emotional shocks, brain-level changes, and tissue adaptations follow a repeating pattern she now sees every day in people's scans and stories. I share two of my own stories – the rash that kept showing up on the right side of my face, and the colon scare that hit during one of the angriest seasons of my life – and how both matched this framework with borderline uncomfortable precision.If you've ever been told your symptoms are random, mysterious, or “just stress,” this conversation offers a very different lens.You'll Learn:[00:00:00] Introduction[00:08:22] Your symptoms are always telling the truth[00:11:04] Dr. Hamer's devastating loss, testicular cancer and the creation of the First Biological Law[00:18:55] What a real conflict shock is and why it's more than just being stressed out[00:25:11] The Five Biological Laws[01:06:29] The arrogance of not respecting, trusting and understanding nature's design[01:18:27] Why Ted Kaczynski's early separation trauma explains his later violent patterns[01:24:15] What happens when territorial anger and identity conflict strike at the same time[01:30:44] Brain layers, hormones, and hierarchy biology[01:44:49] How does our belief impact our physiology and symptoms?[02:02:15] Why doesn't everyone who experiences the same conflict develop symptoms?[02:23:13] Why seizures happen according to German New Medicine[02:37:22] Why do young babies get sick?[02:39:20] Can belief override or amplify the physical effects of harmful or beneficial substances?[02:46:22] Your body is infinitely adaptable, if you're relaxed[02:56:34] Is German New Medicine truly a universal biological law?[03:00:55] What to do when you can't figure out what the conflict was that is causing your symptoms[03:04:30] How to actually resolve your conflicts & why are there some conflicts you might not want to resolve?[03:09:26] When the healing phase would be too intense, surgery is still a good option[03:41:23] How your internal story shapes whether you lean into victimhood or transformation[03:43:29] Similarities between Traditional Chinese Medicine and German New Medicine[03:49:17] What allergies really are[03:59:01] Bringing conflicts into consciousness can offer immediate resolution[04:00:12] Detective work stories of deciphering conflicts and symptoms[04:12:52] Why forcing healing doesn't workResources Mentioned:The Way Forward episode on German New Medicine with Dr. Melissa Sell | Apple or SpotifyDr. Hamer | WebsiteGHK Self Study Bundle | WebsiteUse discount code TWF50 and save $50 off Melissa's course The Bio-Logical Woman starting February 2026.Find more from Dr. Melissa:Dr. Melissa Sell | WebsiteDr. Melissa Sell | YouTubeDr. Melissa Sell | FacebookDr. Melissa Sell | InstagramDr. Melissa Sell | XFind more from Alec:Alec Zeck | InstagramAlec Zeck | XThe Way Forward | InstagramThe Way Forward is Sponsored By:RMDY Academy & Collective: Homeopathy Made AccessibleHigh-quality remedies and training to support natural healing. Enroll hereExplore hereCreate a cleaner energetic space, go to AiresTech.com and use code TWF25 at checkout for 25% off your entire order.New Biology Clinic: Redefine Health from the Ground UpExperience tailored terrain-based health services with consults, livestreams, movement classes, and more. Visit www.NewBiologyClinic.com and use code TheWayForward for $50 off activation. The Way Forward members get the $150 fee waived

Today, I'm joined by the brilliant Dr. Elena Gross, a neuroscientist with an inspiring story and a relentless drive to solve the mysteries behind chronic migraines and brain health. Dr. Gross's personal journey—enduring twenty days of migraine each month and navigating countless failed treatments—led her from crawling through the pain to founding Brain Ritual, a company reimagining brain fuel for longevity.   Episode Timestamps: Intro and offers ... 00:00:00 Elena Gross's journey from chronic migraines to neuroscience ... 00:46 Distinguishing migraines from headaches ... 08:13 Energy deficit in the brain and ketones as a solution ... 15:05 Mechanisms and benefits of ketones for brain health ... 23:03 Micronutrients and mitochondrial support ... 28:20 Perfume, toxins, and migraine triggers ... 32:30 Hormonal, dietary, and oxidative stress factors in migraines ... 34:33 Exogenous ketones: Types, safety, and application ... 44:43 Brain Ritual supplement overview ... 47:04 Expanding beyond migraines: Mitochondria and neuropsychiatric health ... 57:31 Four pillars for mastering migraines ... 67:00 Actionable starting step for listeners ... 71:58 How to access Brain Ritual and community ... 73:10   Our Amazing Sponsors: Regenerive - Most cheap Ashwagandha is bulked up with stems and leaves to inflate the "actives." Those parts can bring compounds you don't actually want in your body. A root-only extract containing four newly identified bioactives, the ASHX4 Complex. Visit regenerive.co and use code NAT25 for 25% off.   StemRegen - A plant-based supplement protocol designed to enhance stem cell function. support your recovery, flexibility, and long-term vitality. Visit stemregen.co/NAT15 and use code: NAT15 for 15% off your order.   Blue Peptide Spray from Young Goose - brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Send us a textWe look at the emerging research linking ultramarathoning to a possible increased risk of colorectal cancer, particularly in individuals with inflammatory bowel disease (IBD). The discussion highlights the importance of hydration, nutrition, and recovery strategies for endurance athletes. Vitamin D and gut health also play an important role in decreasing risks. Takeaways-- Some research suggests that Ultramarathoning may increase the risk of colorectal cancer.- Hydration and nutrition are critical for endurance athletes.- Vitamin D levels should be regularly assessed, especially in athletes.- The gut microbiome can change with extreme endurance activities.- Recovery is essential for preventing long-term damage in athletes.- Training the gut to tolerate nutrition is important for performance.- Repeated extreme endurance events can lead to gut ischemia (lack of blood flow).- Nutrient deficiencies can exacerbate health risks in athletes with IBD.- A tailored approach to nutrition is necessary for athletes with IBD.- Understanding the mechanisms behind gut health can inform better training practices.Chapters:00:00- Introduction to Ultrarunning and Colon Cancer Risk02:37- Exploring the Connection Between Endurance and Colorectal Cancer05:17- The Role of Hydration and Nutrition in Endurance Sports08:07- Nutritional Considerations for Athletes with IBD10:48- The Importance of Vitamin D in Athletic Performance13:38- Understanding the Mechanisms of Gut Damage in Endurance Athletes16:23- The Impact of Recovery on Gut Health19:05- Conclusions and Recommendations for Athletes with IBDFollow us on instagram @crohns_and_colitis_dietitiansFollow us on youtube @thecrohnscolitisdietitiansWe love helping provide quality content on IBD nutrition and making it more accessible to all through our podcast, instagram and youtube channel. Creating the resources we provide comes at a significant cost to us. We dream of a day where we can provide even more free education, guidance and support to those with IBD like us. We need your support to do this. You can help us by liking episodes, sharing them on your social media, subscribing to you tube and telling others about us (your doctors, friends, family, forums/reddit etc). Can you do this for us? In return, I promise to continually level up what we do here.

Featuring an interview with Dr Erika Hamilton, including the following topics: General overview of the mechanisms of action of endocrine-targeted therapies for breast cancer (0:00) Downregulation of estrogen receptor expression levels with endocrine therapy; therapeutic benefit of selective estrogen receptor degraders (SERDs) and proteolysis-targeting chimeras (PROTACs) in ESR1 wild-type and ESR1-mutant breast cancer (5:11) Mechanisms of resistance to endocrine therapy (10:08) Efficacy and toxicities observed with SERDs and PROTACs for HR-positive breast cancer (15:26) Other applications for PROTACs (24:24) Emerging data from the Phase III evERA trial (27:38) Perspectives on clinical investigator and general medical oncologist practice pattern survey results (30:51) CME information and select publications

In this episode, I'm explaining what I believe is the most powerful tool we've ever had to slow and reverse the aging process.  We'll dive into the science behind why your body loses its regenerative fire as you age and how mesenchymal stem cells (MSCs), especially from young birth tissue, can reignite that healing intelligence from within.I've seen firsthand how inflammation silently drives disease and aging. Young mesenchymal stem cells have the ability to calm that Inflammaging fire and reawaken our body's natural healing systems.Let's talk about what's possible when we tap into the original code of life.Key TakeawaysIntroduction (00:00)Stem cell therapy and DNA intelligence (01:03)Inflammation and aging (07:07)Mechanisms of stem cell function (10:09)Comparison of young and old MSCs (21:56)Anti-aging benefits of stem cell therapy (31:34)Human studies and frailty (39:09)Anti-aging protocol and safety (41:57)Additional Resources:✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

Featuring a slide presentation and related discussion from Dr Erika Hamilton, including the following topics: Mechanisms of endocrine resistance; incidence of ESR1 mutations in breast cancer (0:00) Testing methods for ESR1 mutations in patients with breast cancer; therapeutic options for patients with ESR1-mutant breast cancer (3:59) General overview of proteolysis-targeting chimeras (PROTACs); comparison of PROTAC estrogen receptor (ER) degraders and selective ER degraders (7:39) Early-phase data with vepdegestrant monotherapy or in combination with CDK4/6 inhibitors in ER-positive, HER2-negative metastatic breast cancer (mBC) (11:54) Phase III VERITAC-2 trial of vepdegestrant versus fulvestrant in ER-positive, HER2-negative mBC previously treated with endocrine therapy and a CDK4/6 inhibitor (17:48) Ongoing clinical trials evaluating vepdegestrant in novel combinations or treatment settings; other clinical applications of PROTACs (26:08) CME information and select publications

Read the article here: https://journals.sagepub.com/doi/full/10.1177/30494826251344846

Editor’s Choice: A phase II, randomized, double-blind study of the use of rucaparib vs. placebo maintenance therapy in metastatic and recurrent endometrial cancer

It's World AMR Awareness Week (WAAW) and we have prepared a special episode in light of that. In this week's Communicable, Navaneeth Narayanan and Thomas Tängdén host Aula Abbara (London, UK), Guido Granata (Rome, Italy) and Tuomas Aro (Helsinki, Finland) to discuss the phenomenon of AMR in conflict and crisis zones. They elaborate on how difficult conditions and austere environments amplify the spread of AMR, drawing on findings from the ongoing conflicts in Ukraine, Gaza, Syria and other regions. Other topics covered include adapting antimicrobial stewardship and infection prevention and control (IPC) practices as well as the need for genuine political will and international collaboration to end conflicts and their exacerbation on AMR.This episode follows the webinar “Beyond the frontlines” organised by ESCMID's AMR Action Subcommittee for WAAW 2025, featuring the same guests, and is available on ESCMID Media. This Communicable episode was peer reviewed by Arjana Zerja of Mother Theresa University Hospital Centre, Tirana, Albania.  Related ESCMID and Communicable mediaESCMID Media, Part 1: Beyond the frontlines - tackling AMR in conflict and crisis zones, webinar Communicable episode 11: Nightmare series, part 2 – how to deal with carbapenemase producers Communicable episode 16: Climate change and infections – effects on clinical practice & sustainabilityResourcesTrainee Association of ESCIMD (TAE) Doctors without Borders (Médecins sans Frontières), Antibiogo, https://www.antibiogo.org/Doctors without Borders (Médecins sans Frontières), Mini-lab, https://fondation.msf.fr/en/projects/mini-lab Further ReadingAbbara A, et al. Unravelling the linkages between conflict and antimicrobial resistance. NPJ Antimicrob Resist. 2025. DOI: 10.1038/s44259-025-00099-yAbbara A, et al. A summary and appraisal of existing evidence of antimicrobial resistance in the Syrian conflict. Int J Infect Dis. 2018. DOI: 10.1016/j.ijid.2018.06.010Abu-Shomar R, et al. Multidrug-resistant Pseudomonas isolated from water at primary health care centers in Gaza, Palestine: a cross-sectional study. IJID Reg. 2025. DOI: 10.1016/j.ijregi.2025.100671Aldbis A, et al. The lived experience of patients with conflict associated injuries whose wounds are affected by antimicrobial resistant organisms: a qualitative study from northwest Syria. Confl Health. 2023. DOI: 10.1186/s13031-023-00501-4Aro T, et al. War on antimicrobial resistance: high carriage rates of multidrug-resistant bacteria among war-injured Ukrainian refugees. Clin Microbiol Infect. 2025. DOI: 10.1016/j.cmi.2025.07.010  Bazzi W, et al. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front Microbiol. 2020. DOI: 10.3389/fmicb.2020.00068 Dewachi O. War Biology and Antimicrobial Resistance: The Case of Gaza, AMR Insights, 2024.Granata G, et al. The impact of armed conflict on the development and global spread of antibiotic resistance: a systematic review. Clin Microbiol Infect. 2024. DOI: 10.1016/j.cmi.2024.03.029 Huang XZ, et al. Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. Epidemiol Infect. 2012. DOI: 10.1017/S0950268811002871Hujer KM, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006. DOI: 10.1128/AAC.00778-06Karah N, et al. Teleclinical Microbiology: An Innovative Approach to Providing Web-Enabled Diagnostic Laboratory Services in Syria. Am J Clin Pathol. 2022. DOI: 10.1093/ajcp/aqab160Keen EF 3rd, et al. Evaluation of potential environmental contamination sources for the presence of multidrug-resistant bacteria linked to wound infections in combat casualties. Infect Control Hosp Epidemiol. 2012. DOI: 10.1086/667382Murray CK, et al. Recovery of multidrug-resistant bacteria from combat personnel evacuated from Iraq and Afghanistan at a single military treatment facility. Mil Med. 2009. DOI: 10.7205/milmed-d-03-8008Petersen K, et al. Diversity and clinical impact of Acinetobacter baumannii colonization and infection at a military medical center. J Clin Microbiol. 2011. DOI: 10.1128/JCM.00766-10Scott P, et al. An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. Clin Infect Dis. 2007. DOI: 10.1086/518170Sensenig RA, et al. Longitudinal characterization of Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonizing and infecting combat casualties. Am J Infect Control. 2012. DOI: 10.1016/j.ajic.2011.03.025World Health Organization. Fourth WHO Global Evidence Review on Health and Migration stresses that equitable access to and appropriate use of antibiotics for refugees and migrants is essential to tackling Antimicrobial Resistance, News, 2022.

Suleika Jaouad was diagnosed with cancer at 22. She made her illness the subject of a New York Times column and a memoir, Between Two Kingdoms. She and Steve talk about what it means to live with a potentially fatal illness, how to talk to people who've gone through a tragedy, and ways to encourage medical donations. SOURCES:Suleika Jaouad, author. RESOURCES:The Book of Alchemy: A Creative Practice for an Inspired Life, by Suleika Jaouad (2025).The Alchemy Journal, by Suleika Jaouad (2025).“The Art of Survival,” by Jennifer Senior (The Atlantic, 2024).American Symphony, film by Matthew Heineman (2023).Between Two Kingdoms: A Memoir of a Life Interrupted, by Suleika Jaouad (2021).“Max Ritvo, Poet Who Chronicled His Cancer Fight, Dies at 25,” by John Schwartz (The New York Times, 2016).“Life, Interrupted,” column by Suleika Jaouad (The New York Times, 2012-2015).The Fault in Our Stars, by John Green (2012).Bright-sided: How Positive Thinking Is Undermining America, by Barbara Ehrenreich (2009).The Isolation Journals, newsletter by Suleika Jaouad. EXTRAS:“John Green's Reluctant Rocket Ship Ride,” by People I (Mostly) Admire (2022).“Does Death Have to Be a Death Sentence?” by People I (Mostly) Admire (2022). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Medications such as Ozempic, Mounjaro and more have been popular in the media in recent years, but how can they affect menopause? In this episode, Adele unpacks the truth behind the buzz surrounding GLP-1 medications. Are they really miracle weight loss drugs for those in menopause? Nauck, M. A., Quast, D. R., Wefers, J., & Meier, J. J. (2021). GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art. Molecular Metabolism, 46, 101102. https://doi.org/10.1016/j.molmet.2020.101102   Holst, J. J., & Madsbad, S. (2016). Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor. Surgery for Obesity and Related Diseases, 12(6), 1236–1242. https://doi.org/10.1016/j.soard.2016.02.033 ____________ Check out Adele's FREE symptom assessment here: https://adelejohnstoncoaching.com/free-copy-of-our-symptom-assessment/ 12 Minute Breathwork Method: https://adelejohnstoncoaching.com/breathwork/ The Menopause Cheat Sheet: https://docs.google.com/document/d/1ka-fN6J5DJW2J3IE0Qa80zFCKFXmTs4srlnlXYBf-gA/edit?usp=sharing If you want a chat for your future success, fuel yourself here: https://calendly.com/adelejohnston/successchat Download Adele's Journey Journal here : https://adelejohnstoncoaching.com/my-journey-journal/ Enquire about 121 coaching here : https://docs.google.com/forms/d/e/1FAIpQLSfw6vrmKPE7A1eYDKQJiR9No7ZDdpfq-grBdKYjZSR-vl0Qag/viewform For extra support: Support@adelejohnstoncoaching.com ____________ From your host : Adele Johnston I'm Adele Johnston, a certified nutritionist and positive psychology coach, passionate about helping women improve their menopause health and reclaim who you are without menopause taking over. This is a time in your life where you get to feel vibrant, sexy and reclaim you again! I'm proud to work with women like you and have created a very successful proven Reclaiming You 3 STEP PROCESS to help you take back control of your body during your menopause. For more details : https://adelejohnstoncoaching.com/ To get Adele's FREE 3-step Menopause Weight Loss Guide: https://adelejohnstoncoaching.com/menopause-weight-loss-guide/

Send us a text On October 26, 2025, the Rapid Support Forces seized Al-Fashir, the last government-held city in Darfur. What followed was one of the deadliest massacres of Sudan's brutal civil war. Over 460 patients and companions were killed at the Saudi Maternity Hospital on October 28th alone, with total death tolls exceeding 2,500 people. In this episode, we uncover the horrifying reality of the RSF's systematic violence in Darfur, examine the international community's silence, and explore what accountability looks like when war crimes unfold in real time. Our guest for today is Dr. Abdulla Hafeez and Khadega Mohamed.  This is a story the world needs to hear.  WHAT YOU'LL LEARN: • The October 26-28 Al-Fashir massacre timeline and verified death tolls • Who the Rapid Support Forces are and how they gained power in Sudan • The strategic importance of Al-Fashir as Darfur's last government stronghold • Evidence of systematic attacks on hospitals and medical infrastructure • The role of external actors, particularly UAE support for RSF operations • Why this crisis receives minimal international media coverage • The humanitarian catastrophe facing 12 million displaced Sudanese civilians • Mechanisms for documenting war crimes and pursuing justice • Potential scenarios for ending the violence in Darfur and broader Sudan You can donate here:   https://sapa-usa.org/el-fasher-emergency-response/  https://sapa-usa.org/?gad_source=1&gad_campaignid=22771252936&gbraid=0AAAAA-5PS-mE0vzyYCK1teCA7XYxUkEpP  Subscribe for more investigative journalism covering the stories mainstream media ignores. Share this episode to raise awareness about Sudan's ongoing humanitarian catastrophe. Visit Ozmedia313.com for more in-depth coverage.Follow us on social media:- Instagram: @motivateme313 or @ozmedia313- Website: ozmedia313.com- Facebook: ozmedia313-TikTok: @ozmedia313-Apple Podcast: ozmedia-Spotify Podcast: ozmediaThis show was sponsored by:-The Family Doc https://thefamilydocmi.com/-Juice Box Juiceboxblend.com-Holy Bowly http://www.myholybowly.com-Wingfellas thewingfellas.com-Hanley International Academy https://www.hanleyacademy.com-Malek Al-Kabob malekalkabob.com-Bayt Al Mocha https://baytalmocha.com/-Chill Box https://www.chillboxstore.com/-Royal Kabob https://www.royalkabob.com/-GEE Preparatory Academy https://www.gee-edu.com/schools/geepreparatory/index#SudanWar #DarfurConflict #SudanCivilWar #AfricaNews #LatestNews #WorldNews 

Ultra-processed foods have become central to the way we eat and to many of the challenges we face in public health nutrition. They dominate supermarket shelves, shape population diets, and often appear as the prime suspect in rising obesity and metabolic disease rates. But beyond the label itself, what exactly makes these foods problematic? Is it their nutrient composition, their texture and palatability, the rate at which we consume them, or the broader environments that make them so accessible and appealing? The debate around ultra-processed foods sits at the intersection of metabolic science, behaviour, and policy. It raises uncomfortable questions about how food systems evolved to prioritise convenience and profit, and what it might take to meaningfully change that trajectory. In this episode, Dr. Kevin Hall joins the podcast to examine the evidence from controlled feeding studies and population research, exploring what we really know about ultra-processed foods, overeating, and how we might begin to fix the food environment. Timestamps [04:24] Dr. Hall's background and career [06:47] Ultra processed foods and health [15:10] Mechanisms behind ultra processed foods [27:00] Healthy ultra processed foods: a possibility? [30:43] Minimizing ultra processed foods in different cultures [33:03] Policy and regulation for better food quality [44:26] The importance of pilot studies in policy implementation [49:10] Future of food and sustainable diets [51:50] Key ideas segment (Premium-only) Links & Resources Go to episode page (with links to studies) Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course X: @KevinH_PhD @NutritionDanny Book: Food Intelligence: The Science of How Food Both Nourishes and Harms Us Previous episodes with Dr. Hall: #429, 376, 165, 88

Send us a textThis week we are talking about our life lines. I ask you to consider — who's your lifeline?Not the metaphorical one, but the real, human connection that keeps you afloat when life gets heavy.We'll dig into the interesting history of the word “lifeline,” what research says about how connection affects our health and habits, and how you can create your own H-Factor system of support.It's practical and deeply human —you'll leave reminded that you were never meant to do this alone. Quote of the week“My humanity is bound up in yours, for we can only be human together. When we see the other as part of ourselves, we begin to build a world where no one is left behind.”by Desmond TutuInstagram: fina.projectweightlossCitationsEtymonline. (2024). Lifeline – Origin & Definition. Retrieved from etymonline.comUchino, B. N. (2020). Social support and health: A review of physiological processes potentially underlying links to disease outcomes. National Center for Biotechnology Information (NCBI).Lakey, B., & Orehek, E. (2022). Perceived social support and mental health: A review of recent findings.Frontiers in Psychology.Maher, C. A. et al. (2020). Social support and weight-loss interventions: Mechanisms of behavior change.Frontiers in Psychology.Let's go, let's get it done. Get more information at: http://projectweightloss.org

Mentor Sessions Ep. 037: Michael Morelli on Rock Bottom Addiction Recovery, Building a Bitcoin-Powered Fitness Empire, Parallels to Sound Money & Radical LongevityMichael Morelli's Bitcoin journey mirrors his brutal addiction recovery: from high more than sober for a decade, snorting oxycodone amid bankruptcy and affairs, to a 113-day shred from 25% to 8% body fat—bootstrapping FitScript into a multimillion-dollar data-driven health empire coaching 600+ men with peak biomarkers while stacking BTC as a maxi since 2020. Inspired by Saifedean Ammous' "The Bitcoin Standard," Morelli draws logical parallels between paleo nutrition's ancestral simplicity and Bitcoin's finite, sound money—why it's the only asset that "just seems logical" in a fiat-fueled health and wealth disparity crisis. In this BTC Sessions interview, he busts carnivore myths (labs "fucking wrecked"), unpacks peptides for faster gains, red light therapy hacks, and his no-excuses mantra: if a coke-addicted bankrupt can rebuild to live until 150, stacking sats with low-time preference, Bitcoiners have zero excuses for subpar health. Topics:Brutal rock bottom: Addiction, abuse & what led there113-day rebirth: Fatherhood spark & no-excuses mindsetBootstrapping empire: Mom's basement to millionsFitness myths busted: Carnivore dangers & paleo logicBitcoin awakening: Shitcoins to maxi via SaifedeanHealth-money parallels: Disparity extremes & white coat trapsActionable optimization: Low-hanging fruit for BTC stackersPeptides decoded: Mechanisms for faster recoveryRed light therapy: Mitochondria boost & hair regrowthEntrepreneurship grit: Fuck Aging brand & mindset masteryChapters:00:00 Teaser & Intro01:24 Background & Journey02:09 Addiction & Rock Bottom04:42 No Excuses06:10 Abuse & Roots13:04 Fitness & Control16:34 Empire Collapse19:03 Biz Success23:42 Myths & Paleo26:13 Lab & FitScript31:05 BTC Parallels & Journey33:06 Disparities & Pharma38:50 Actionable Tips43:07 Longevity & Alpha47:53 Peptides & Red Light1:02:45 Outro & DiscountAbout Michael MorelliPerformance health engineer, founder FitScript. Test, don't guess. X.com: @morellifitFitScript: fitscript.me (mention podcast for $1000 off)Check previous ep with Prince Filip of Serbia: https://youtu.be/h7kyNNUuLOg

Cracked teeth — the diagnosis we all hate as Dentists! How do you decide when to monitor and when to intervene? What is the recommended intervention at different scenarios of cracks? Should we be chasing cracks and reinforcing with fibers; is there actually enough long-term data to support that approach? Over the years, we've had some epic episodes on this topic — from Kreena Patel's “I Hate Cracked Teeth” (PDP028) to Dr. Lane Ochi's Masterclass on Diagnosis and Management (PDP175). But in this brand-new episode, Jaz is joined by Dr. Masoud Hassanzadeh to bring it all together — not just the diagnosis of cracks, but their management. They explore when to intervene, the role of fibers in preventing propagation, and even the fascinating possibility that cracks in teeth may have some ability to heal, just like bone! This one's a deep dive that will change how you talk to patients — and how you approach cracked teeth in your own practice. https://youtu.be/VHYRBnfJS3I Watch PDP246 on YouTube  Protrusive Dental Pearl Your patient's history predicts the future! Ask if past extractions were difficult → clues you into anatomical challenges. Ask how they lost other teeth → if cracks, be proactive with today's cracks. History isn't just background—it's a clinical tool. Key Takeaways Cracks in teeth can be diagnosed using magnification and high-quality imaging. Patient factors such as age and muscle strength play a significant role in crack prognosis. Symptomatic cracks should be treated to prevent further propagation. Understanding the anatomy of the tooth is crucial for effective treatment. The healing mechanism of cracks in teeth is possible but varies between enamel and dentin. Fibers can be used to strengthen restorations and manage cracks effectively. Long-term studies are needed to assess the effectiveness of current crack management protocols. The use of fluorescence filters can help identify bacteria in cracks. Chasing cracks should be done cautiously to avoid pulp exposure. A comprehensive understanding of crack mechanics can improve treatment outcomes. Highlights of this episode: 00:00 Teaser 00:47 Intro 03:08 Protrusive Dental Pearl - The Importance of Dental History 07:18 Interview with Masoud Hassanzadeh 08:22 Diagnosing and Managing Cracks 21:13 When to Intervene on Cracks 25:50 Restoration Techniques and Materials 28:30 Chasing Cracks: Guidelines and Techniques 36:50 Mechanisms of Crack Healing in Teeth 45:11 Exploring the Use of Fibers in Dentistry 52:43 Introducing the Book on Cracked Teeth 54:57 Percussion-Based Diagnostics (QPD) 56:44 Key Takeaways 57:21 Conclusion and Final Thoughts 01:00:07 Outro As promised, here are the studies mentioned during the discussion: Why cracks do not propagate as quickly in root dentin: Study 1a & 1b Root dentin has significantly higher fracture toughness compared to coronal dentin—nearly twice as tough, as demonstrated in multiple studies. The key difference lies in their structure and toughness. Root dentin's unique collagen orientation adds strength, while its fewer lumens and thinner peritubular cuffs make it less brittle. In contrast, coronal dentin has thicker cuffs, which increase brittleness. Unlike coronal dentin, which fractures uniformly, radicular dentin is anisotropic—its fracture behavior varies depending on direction. These structural features give root dentin greater resistance to cracking, making it more durable under stress. Studies on decreasing crack length due to crack repair in enamel. Study 2 The importance of the modulus of elasticity of the final restoration in arresting crack propagation. Study 3 The role of fiber in restoring cracked teeth and how it can increase fracture strength—even surpassing that of natural teeth. Study 4 Decision Making for Retention of Endodontically Treated Posterior Cracked Te...

In this episode of the Flex Diet Podcast, I sit down with my good friend Dr. Dan Pardi for a deep dive into all things health, longevity, and cognitive performance. We get into the science of stem cells and aging, the real benefits (and limits) of popular supplements, and how nootropics like Ritalin and Modafinil actually work—or don't—in the real world.We also talk about how to integrate training and movement into insanely busy lives, the psychology of health behavior, and why being flexible in your approach (not just in your hamstrings) is key to long-term success.This episode is brought to you by Quaia Life, where Dan's doing some fascinating work on cutting-edge supplements designed to optimize health and performance. They're offering listeners 15% off their products, which you can grab through the link in the show notes.If you want a mix of actionable tips, science-backed insights, and a peek behind the curtain of how top researchers think about performance and aging, you'll definitely want to tune in.Sponsors:Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8Qualia: https://qualialife.com/drmike15Coupon Code: DRMIKE15 (listeners get an additional 15% off any Qualia order)Available now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:01:51 Science Communication and Cognitive Performance02:43 Sponsorship and Product Endorsement04:54 The Importance of Flexibility in Training06:39 Integrative and Opportunistic Training15:50 The Psychology of Health and Performance24:12 Quality of Life and Nootropics31:12 Understanding Cognitive Enhancement44:30 Modafinil and Its Effects50:50 Exploring the Benefits and Downsides of a New Drug51:22 Mechanisms and Effects of the Drug52:42 Hallmarks of Aging and Their Impact58:07 Understanding Stem Cells and Their Functions01:01:52 Formulating a Stem Cell Supplement01:10:18 Sequencing Protocols for Optimal Health01:15:13 Challenges and Research in the Supplement Industry01:23:33 Final Thoughts and Recommendations01:34:29 Podcast Conclusion and Disclaimers Flex Diet Podcasts You May Enjoy: Episode 263: Lifestyle, Longevity, and the Future of GLP-1 Agonist Use in Wellness with Christa RymalYouTube: https://youtu.be/SlALIb74KvMEpisode 165: Health, Sports Performance and Longevity Medicine: Dr Rick Cohen with Dr. Mike T NelsonYouTube: https://youtu.be/bYk_wzBJzJYConnect with Dr Pardi:Qualia: https://www.qualialife.com/Instagram: https://www.instagram.com/dan_pardiGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

In this episode of the Epigenetics Podcast, we talked with Vincent Pasque from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. We begin by tracing Vincent's journey into biology, sparked by early childhood experiences in nature and meaningful encounters with inspiring teachers. His fascination with the complexities of biology crystallized during a pivotal moment while listening to a radio segment on epigenetics in the late '90s, which led him to pursue studies in genetics and biochemistry. This formative path brought him to leading institutions, including the prestigious lab of John Gurdon, where he explored the phenomenon of nuclear reprogramming. Vincent recounts his early experiments that led to the discovery of macro H2A as a barrier to reprogramming, emphasizing the core challenge of erasing somatic cell identity. As the conversation unfolds, Vincent introduces us to critical findings from his research. He shares how the inactive X chromosome serves as a compelling model to investigate epigenetic regulation, revealing that the dynamics of reprogramming and differentiation are far from simple reversals of development. He highlights the significant differences between male and female iPSCs and how X-linked genes influence DNA methylation and differentiation rates in these cells. The implications of these findings extend beyond developmental biology to inform our understanding of diseases, particularly cancer. Transitioning to his current work, Vincent describes pioneering advances in characterizing the chromatin-associated proteome during the differentiation of human pluripotent stem cells. The surprising discovery of elevated histone modifications in naïve cells leads to intriguing questions about the barriers to cellular plasticity and the mechanisms by which cells resist alternative fate conversions. The potential applications of this research could reshape our approach to regenerative medicine and therapeutic interventions. References Pasque V, Gillich A, Garrett N, Gurdon JB. Histone variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal. 2011 May;30(12):2373-2387. DOI: 10.1038/emboj.2011.144. PMID: 21552206; PMCID: PMC3116279. Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C. R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi, K., & Gurdon, J. B. (2014). Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming. Molecular Cell, 55(4), 524–536. https://doi.org/10.1016/j.molcel.2014.06.024 Pasque V, Tchieu J, Karnik R, et al. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014 Dec;159(7):1681-1697. DOI: 10.1016/j.cell.2014.11.040. PMID: 25525883; PMCID: PMC4282187. Zijlmans DW, Talon I, Verhelst S, et al. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology. 2022 Jun;24(6):858-871. DOI: 10.1038/s41556-022-00932-w. PMID: 35697783; PMCID: PMC9203278. Related Episodes The Discovery of Genomic Imprinting (Azim Surani) Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle) Epigenetics and X-Inactivation (Edith Heard) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

In this episode, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, dives deep into estrone, one of the three key estrogens, and explains why understanding it is crucial for women's health. Learn about: The differences between estradiol, estriol, and estrone How estrone levels shift during perimenopause and menopause Why oral estrogen can dramatically increase estrone The impact of lifestyle factors like diet, body fat, stress, alcohol, and sedentary behavior on estrogen balance Practical tips to support healthy estrogen metabolism naturally Dr. McCarthy breaks down complex biochemistry in a clear, actionable way so you can take charge of your hormonal health.   Citations: 1. Bulun, Serdar E., et al. “Aromatase and Estrogen Biosynthesis in Adipose Tissue.” Endocrine Reviews, vol. 23, no. 3, 2002, pp. 305–342. 2. Labrie, Fernand, et al. “Importance of the Intracrinology of Estrogen Synthesis in Peripheral Tissues in Postmenopausal Women.” Journal of Steroid Biochemistry and Molecular Biology, vol. 118, nos. 4–5, 2010, pp. 273–279. 3. Sasano, Hironobu, and Toshihiko Harada. “Differential Expression of Aromatase and 17β-Hydroxysteroid Dehydrogenase Isoenzymes in Human Tissues.” Journal of Steroid Biochemistry and Molecular Biology, vol. 86, no. 3–5, 2003, pp. 327–333. 4. Yager, James D., and Nancy E. Davidson. “Estrogen Carcinogenesis in Breast Cancer.” New England Journal of Medicine, vol. 354, no. 3, 2006, pp. 270–282. 5. Cavalieri, Ercole L., and Eleanor G. Rogan. “Depurinating Estrogen-DNA Adducts, Mechanisms of Formation, and Prevention.” Clinical Cancer Research, vol. 16, no. 3, 2010, pp. 596–602. 6. Suba, Zsuzsanna. “Circulating Estrogens and Estrogen Metabolism in Obese Women.” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 11, 2013, pp. 4336–4344. 7. Simpson, Evan R., and Konstanze C. Pike. “Aromatase Expression in Adipose Tissue: Relationship to Obesity and Insulin Resistance.” Endocrinology, vol. 156, no. 9, 2015, pp. 3422–3435. 8. Key, Timothy J., et al. “Circulating Sex Hormones and Breast Cancer Risk Factors in Postmenopausal Women: Reanalysis of 13 Studies.” British Journal of Cancer, vol. 105, no. 5, 2011, pp. 709–722. 9. Stanczyk, Frank Z., et al. “Oral, Transdermal and Injectable Hormone Therapy: Pharmacokinetics and Effects on Estrone/Estradiol Ratios.” Menopause, vol. 24, no. 9, 2017, pp. 1080–1090. 10. Santen, Richard J., et al. “Estrogen Bioidentical Hormone Therapy: Route of Administration and Risk.” Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 7, 2020, pp. 2062–2074. 11. Zeleniuch-Jacquotte, Anne, et al. “Postmenopausal Levels of Estrone, Estradiol, and Estrone Sulfate and Breast Cancer Risk.” Cancer Epidemiology, Biomarkers & Prevention, vol. 23, no. 8, 2014, pp. 1531–1539. 12. Dall, Gabriella V., and Christine L. Clarke. “Local Estrogen Biosynthesis and Signaling in Breast Cancer Progression.” Steroids, vol. 78, no. 7, 2013, pp. 639–646. 13. Heald, Anthony H., et al. “Relationships Between Serum Estrone, Insulin Resistance, and Adiposity in Postmenopausal Women.” Clinical Endocrinology, vol. 67, no. 3, 2007, pp. 340–345. 14. Kuiper, George G. J. M., et al. “Estrogen Receptor β Selectivity of Estriol and Implications for Tissue-Specific Effects.” PNAS, vol. 94, no. 17, 1997, pp. 9105–9110. 15. Michnovicz, Joseph J., et al. “Dietary Indoles and Estrogen Metabolism: Effects of Cruciferous Vegetable Intake.” Journal of Nutrition, vol. 134, no. 12, 2004, pp. 3479S–   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

Send Vanessa a Text MessageNEW WEBSITE: https://intentionallywellpodcast.com/In this episode, I sit down with William Parker, PhD, a scientist with decades of research in biochemistry, microbiology, and immunology. Best known for discovering the function of the human appendix and as a leading researcher studying acetaminophen (Tylenol) and its impact on neurodevelopment, William shares his insights on a topic that has recently garnered widespread media attention and public discussion, sparking conversation around acetaminophen and autism risk.We explore:How acetaminophen interacts with the body during critical periods of developmentThe biological pathways connecting acetaminophen exposure to neurodevelopmental outcomesWhy this research matters to parents, caregivers, and anyone invested in child healthCommon questions, concerns, and rebuttals surrounding acetaminophen and autism riskThe gaps in pediatric education and medical literature that often leave these risks under-discussedThis episode is designed to break down complex science in a way that is understandable, actionable, and presented through a compassionate and logical lens. Whether you're a parent, healthcare professional, or just curious, you'll walk away with a clearer understanding of the evidence, the controversies, and the implications for children's health today.For those who'd like to explore Dr. Parker's research and related literature, here are the studies and resources mentioned in this episode:Acetaminophen and Autism: Evidence from a Systematic Review (MDPI, 2024)Mechanisms of Acetaminophen-Induced Neurodevelopmental Effects (MDPI, 2024)Preprint: Revisiting Acetaminophen and Autism—A Global Call for Reevaluation (2025)Preprint: Acetaminophen, Oxidative Stress, and Neurodevelopmental Risk (2025)Prevent Autism—Educational and Research ResourceEvidence That Acetaminophen Triggers Autism in Susceptible Individuals Has Been Ignored and Mishandled for More Than a Decade (RealClear Public Health, 2025)Connect with the show:Podcast on InstagramVanessa on InstagramPodcast on YouTubePodcast on TikTokPodcast on XEmail: intentionallywellpodcast@gmail.comSupport the ShowIf this podcast has encouraged you and you'd like to help me continue sharing impactful content, you can support the show here:Support the Show© 2025 Vanessa Lopez, Intentionally Well Podcast. All rights reserved. No part of this podcast or show notes may be copied, shared, oSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

Why does it work? Proposed biomedical effect mechanisms of exercise-based injury prevention programmes in football (Soccer) and handball: a scoping review of 104 studies Moen C, Myklebust G, Munkvold E, et al. Br J Sports Med. 2025;59(20):1435-1442. doi:10.1136/bjsports-2025-109802 Due to copyright laws, unless the article is open source we cannot legally post the PDF on the website for the world to download at will. Brought to you by our sponsors at: CSMi – https://www.humacnorm.com/ptinquest VALD MoveHealth - https://movehealth.me/ Learn more about/Buy Erik/Jason/Chris's courses – The Science PT Support us on the Patreons! Music for PT Inquest: "The Science of Selling Yourself Short" by Less Than Jake Used by Permission Other Music by Kevin MacLeod – incompetech.com: MidRoll Promo – Mining by Moonlight Koal Challenge – Sam Roux

Send us a textEver wonder why some moments with your child feel effortless and deeply connected — while others leave you drained, reactive, or misunderstood? In this episode, we break down the science behind why.Dr. Jessie Stern and psychologist Rachel Samson join Cindy to explore relational savoring — a simple yet powerful way to strengthen your bond by intentionally remembering moments of warmth, safety, and love. You'll learn how this practice calms your nervous system, reduces stress, and builds emotional security — for both you and your child.They also unpack the role of temperament and sensitivity in relationships. Why do some people (and kids) feel everything more deeply? What does that mean for how we connect, comfort, and communicate?If you've ever said, “I wish I could stay calm when things get hard,” this conversation will give you the science and the self-awareness to start doing exactly that.Because connection isn't about perfection — it's about noticing, savoring, and showing up with compassion.Read their new book: Beyond Difficult: An attachment-based guide to dealing with challenging peopleFollow Rachel SamsonFollow Dr. Jessie SternRead the science article: Savoring interventions for mothers of young children: Mechanisms linking relational savoring and personal savoring to reflective functioningListen to more podcast episodes:https://podcasts.apple.com/ca/podcast/reflective-parenting-by-curious-neuron/id1440533170?i=1000731541535Support the showJoin our Reflective Parenting Program to learn the science-based skills parents (and their kids) need to thrive: https://curiousneuron.com/reflective-parent-club/ Record your question, or share a parenting insight in a 1 min audio we will share on the podcast https://www.speakpipe.com/ReflectiveParentingPodcast Book a spot in my calendar to chat about your challenges: https://calendly.com/curious_neuron/chat-with-cindy-reflective-parent-club-clone Grab a Free Resource: FREE Workbook: Staying Calm When Your Child Isn't: A Parent's Guide to Triggers and Emotions Email: info@curiousneuron.com

Cancer now affects 30% to 50% of Americans, a massive increase from just 5% in 1900, reflecting how modern diets and lifestyles have reshaped your body's internal terrain Excess linoleic acid (LA) from seed oils triggers toxic byproducts, chronic inflammation, and mitochondrial breakdown, all of which weaken your body's defenses and fuel tumor growth Lowering LA intake from 7% to around 2% to 3% of daily calories has been shown to cut oxidative stress markers by 20% in as little as 12 weeks, giving your body a chance to recover A four-phase terrain restoration strategy uses seed oil elimination, staged carbohydrate reintroduction, gradual fiber restoration, and metabolic supports like intermittent fasting and exercise to rebuild resilience Simple daily steps — avoiding seed oils, rebuilding gut health, supporting mitochondria through movement and sleep, and tracking progress — give you control over your risk and long-term health