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This week we review a recent book entitled Reimagining a Child's Heart: The Lone Pines of Congenital Cardiology which was recently published by Springer and which was authored by Dr. Thomas J. Kulik and Dr. Macdonald Dick. Drs. Kulik and Dick recount the innumerable steps in discovery that led to what the authors view as one of the pinnacles of achievement in our field, namely the palliation of children with HLHS and single ventricle disease. Dr. Kulik tragically passed suddenly in 2021 but his friend and colleague Dr. Dick completed the book that Dr. Kulik had spent over a decade toiling over. This week we sit down with Dr. Dick and also, briefly, Dr. Roberta Williams and Dr. Kulik's wife Ms. Linda Kulik to discuss the book, Dr. Kulik's legacy, mentorship and more. Dr. Dick also shares with us what he believes are the keys to a successful retirement. This is a rare opportunity to listen to some of the truest pioneers of our field, 'Lone Pines" themselves share their insights and warm stories. For those interested, this is one of many sites to obtain the book:https://www.amazon.com/dp/3031886070?lv=shuf&channelId=500&plpRedirect=mhFallbackAlso mentioned in this episode are 2 prior episodes including our conversation with Dr. Michael Freed and our conversation with Ms. Patricia Meisol and links are below:https://podcasts.apple.com/us/podcast/pediheart-podcast-203-a-conversation-with-dr-michael-freed/id1341472214?i=1000556610155https://podcasts.apple.com/us/podcast/pediheart-podcast-320-the-extraordinary-life/id1341472214?i=1000677938143
ASN Kidney Translation explores advances in Cardiovascular-Kidney-Metabolic syndrome, including building a cardio-nephrology service (Kidney360), cardiorenal benefits of SGLT2 inhibitors & GLP-1 receptor agonists (JASN), & PREVENT risk prediction (CJASN).
What if the GLP-1 conversation is bigger than weight loss? In this episode, I sit down with McCall McPherson, PA-C, thyroid expert and founder of Modern Thyroid Clinic. We have a candid, nuanced discussion about GLP-1 receptor agonists, the clinical questions that extend beyond the scale, and why safety, nutrition, medication sourcing, and individualized follow-up must stay at the center of the conversation. McCall shares the clinical observations that led her team to explore low-dose approaches with some thyroid patients, including questions around inflammation and autoimmune symptoms. We also discuss what is established, what remains under study, and why an episode conversation should never replace a personal discussion with a licensed clinician. Important clinical note: The episode includes discussion of microdosing and possible anti-inflammatory applications. These ideas may be outside FDA-approved uses and are not a plan for self-treatment. Do not start, stop, split, or change a prescription medicine without guidance from a qualified prescriber.
In episode 83 of Going anti-Viral, Dr Steven Grinspoon joins host Dr Michael Saag to provide an update on guidelines for statin use in people with HIV based on results from the REPRIEVE trial. Dr Grinspoon is a Professor of Medicine at Harvard Medical School and a clinician in the Neuroendocrine and Pituitary Tumor Clinical Center and faculty member at the Massachusetts General Hospital. He is a clinical researcher who studies hypothalamic control of body weight and fat distribution in obesity and lipodystrophy with a focus on the metabolic and cardiovascular consequences of visceral fat accumulation. Dr Grinspoon is the author of more than 200 peer-reviewed publications and serves as the chief of the Massachusetts General Metabolism Unit and the director of the Nutrition Obesity Research Center at Harvard. Dr Grinspoon and Dr Saag discuss the latest findings from the REPRIEVE trial and provide updates on statin guidelines for people with HIV as well as providing insights into cardiovascular risk management. They discuss the safety and efficacy of statins and the role of cardiovascular risk calculators in clinical practice in addition to discussing the impact of low-density lipoprotein (LDL) cholesterol and inflammation on cardiovascular risk. Dr Grinspoon also offers his outlook for where further research is needed based on the outcomes of the REPRIEVE trial.0:00 – Introduction 1:33 – Overview of the REPRIEVE trial findings2:44 – Changes in statin guidelines for people with HIV 6:51 – Safety and efficacy of statins9:09 – Use of statins and diabetes risk11:16 – Cardiovascular risk calculators16:00 – Statin use and blood pressure17:14 – Impact of LDL cholesterol and inflammation on cardiovascular risk24:08 – Future directions in cardiovascular research for people with HIV Resources:Going anti-Viral: Episode 56 – Cardiovascular Health in People with HIV – Dr Steven GrinspoonApple Podcasts:https://podcasts.apple.com/us/podcast/the-management-of-cardiovascular-health-in-patients/id1713226144?i=1000725697103 YouTube:https://youtu.be/297vweZ5bjQ REPRIEVE Trial: https://www.reprievetrial.org/ __________________________________________________Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.Going anti-Viral's host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences. Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.Follow Going anti-Viral on: Apple Podcasts YouTubeXFacebookInstagram...
How is AI reshaping the way radiology residents study, dictate reports, and summarize clinical courses? BackTable co-founder Anish Parikh catches up with Dr. Sunny Murthy, a PGY-2/R1 integrated interventional radiology (IR) resident at the University of Virginia (UVA). --- Get the BackTable apphttps://www.backtable.com/app --- More about this episode Dr. Murthy outlines the lecture structure (morning didactics, noon case-based sessions) and a curriculum shift toward on-demand video learning via Modality, alongside books, Radiopaedia, and targeted journal use. They discuss conference learning at SIR, the role of podcasts like BackTable, and balancing information overload. AI comes up in both clinical workflows (Epic-generated hospital-course summaries that can be wrong) and education (Claude/Notion for organizing study), with debate about limiting AI for trainees versus preparing for future practice. The resident explains learning procedures across multiple devices, relying on techs, industry training and exhibit halls, and notes receiving a resident teaching award while emphasizing the need for better IR exposure and simulation-based training content. --- Resources Fundamentals of Body CThttps://www.us.elsevierhealth.com/fundamentals-of-body-ct-9780323608329.html Journal of Vascular and Interventional Radiologyhttps://www.jvir.org/ CardioVascular and Interventional Radiologyhttps://www.cvironline.org/ --- Backtable Industry is the go-to podcast for healthcare leaders, business-minded providers, and innovators that are shaping the future of healthcare. Download the free BackTable app to get early access to new episodes.► https://www.backtable.com/app
HEALTH NEWS Curcumin shows the best balance against cancer, study shows First trial confirms swimming reduces disability from chronic back pain Nanoplastics in Drinking Water May Be Making Dangerous Bacteria Stronger, New Study Warns Kids remember veggie scents from womb, study finds Watermelon Contains Compounds Linked to Cardiovascular and Metabolic Health, Studies Show Curcumin shows the best balance against cancer, study shows Wroclaw Medical University (Poland), July 22 2026 (News-Medical) Curcumin, berberine, and other plant-derived compounds have long attracted scientific interest because of their anti-inflammatory and anticancer properties. A new study by researchers from Wroclaw Medical University, however, shows that not all natural compounds act in the same way, and strong anticancer activity does not always go hand in hand with a good safety profile. The researchers compared five compounds: curcumin, berberine, biochanin A, cucurbitacin E, and CAPE (caffeic acid phenethyl ester), a component of propolis. They investigated how these substances affected fibrosarcoma cells and healthy muscle cells. The study focused on the NF-κB signaling pathway, which regulates inflammation, metabolism, cell survival, and cellular aging. The tested compounds disrupted mitochondrial function, reducing the cancer cells' ability to produce energy. In fibrosarcoma cells, ATP levels decreased by approximately 83–92%, compared with reductions of around 23–73% in healthy muscle cells. This suggests that cancer cells are more vulnerable to disturbances in energy metabolism. The compounds also affected mitophagy, the process responsible for removing damaged mitochondria. All five compounds induced features of cellular senescence in fibrosarcoma cells. In this state, cells remain alive but permanently lose their ability to divide. The strongest effect was observed with curcumin. The proportion of senescent cancer cells increased from approximately 16.5% to more than 75%. For the other compounds, the percentage exceeded 66% as well. Healthy muscle cells generally showed a weaker response, suggesting a degree of selectivity towards cancer cells. First trial confirms swimming reduces disability from chronic back pain Macquarie University, July 21 2026 (Eurekalert) Australian research has shown for the first time that a program of swimming can be clinically effective in reducing disability from chronic low back pain. Publishedin the British Journal of Sports Medicine, the clinical trial found an eight-week individualised program of swimming and education, guided by a physiotherapist, improved function and pain significantly more than education alone in people with back pain. The researchers recruited 76 adults aged 26 to 74 (average 41 years) who were experiencing some disability due to low back pain lasting for at least 12 weeks and allocated them at random to one of two groups. One group received an eight-week individualised program of swimming and education, supported by four telehealth coaching sessions with a physiotherapist. They weren't regular swimmers, but they were able to swim 25 metres and feel confident in the water. The swimming programme was based on a goal of achieving three sessions of 30-45 minutes by the end of the eight weeks. After eight weeks, disability was significantly lower in the swimming group. They improved by about 50 per cent from where they were before starting the program. Compared to the control group who received education only, swimmers scored on average 2.5 points or 30 per cent lower on a widely used disability scale. Nanoplastics in Drinking Water May Be Making Dangerous Bacteria Stronger, New Study Warns Virginia Tech University, July 21 2026 (Natural News) A study published in the journal Water Research found that nanoplastics, tiny plastic particles invisible to the naked eye, can increase the mechanical strength of bacterial biofilms and make them more resistant to disinfectants. The research, conducted by Virginia Tech and an international team, examined how these particles affect microbial communities inside drinking water systems. The findings indicate indirect public health risks through water systems. The nanoplastics can make the antimicrobial-resistant pathogens better survive, which could be harmful to the environment and would have public health implications. The study focused on biofilms containing E. coli and Pseudomonas aeruginosa, two bacteria commonly associated with waterborne infections. When exposed to nanoplastics, the bacteria activated multiple defense mechanisms, resulting in thicker, heavier biofilms. These strengthened biofilms pose a greater challenge for water treatment facilities, according to the researchers. Biofilms are communities of bacteria that attach to surfaces, such as the interior walls of water pipes. These bacterial colonies produce a protective matrix that shields them from environmental threats, including disinfectants. While some biofilms are beneficial, those formed by pathogenic bacteria can pose risks inside drinking water distribution systems. Waterborne nanoplastics are already widespread. A French government study found that glass bottles can contain five to 50 times more microplastics than plastic bottles, with contamination often originating from painted caps. Kids remember veggie scents from womb, study finds Durham University, May 13 2026 (Medical Xpress) Experiencing bitter or non-bitter flavors before birth can shape taste likes or dislikes after being born, according to new research led by the Durham University Department of Psychology. Researchers found that young children are less likely to react negatively to the smell of vegetables they were repeatedly exposed to in the womb. They say their findings could have implications for establishing healthy eating habits in children. The researchers examined the facial reactions of 12 three-year-olds to the non-bitter smell of carrot or the bitter smell of kale. They found that the three-year-olds whose mothers had taken carrot powder capsules as part of a controlled experiment when pregnant were less likely to show negative facial reactions toward the smell of carrot. Similarly, those whose mothers had taken kale powder capsules while pregnant reacted less negatively to the smell of kale. The researchers say their latest finding supports the argument that exposure to flavors in late pregnancy can result in long-lasting odor or flavor memory in children. Watermelon Contains Compounds Linked to Cardiovascular and Metabolic Health, Studies Show UCLA, July 22 2026 (Natural News) Watermelon contains bioactive compounds that have been linked to improvements in cardiovascular function and metabolic healths. The fruit is a source of the amino acid citrulline, which the body converts to arginine, and the antioxidant lycopene, both of which have been associated with positive health outcomes. According to a review in the journal Nutrition clinique et métabolisme, watermelon consumption increases plasma arginine concentrations in adults. The body converts citrulline into arginine, which then supports nitric oxide production, a molecule that helps relax blood vessels. Lycopene, the carotenoid responsible for watermelon's red color, is also present in notable amounts and acts as an antioxidant. Watermelon's L-citrulline and L-arginine content improves arterial function and blood pressure Another report states that citrulline is useful for blood pressure regulation and metabolic health.
This week we discuss a recent report from the team at SickKids in Toronto on minimally invasive cardiac surgery. What sorts of operations are most common for this approach? Why are length of ICU and length of hospitalization periods lower in this surgical cohort than more traditional midline sternotomy approaches? How does one train a surgeon to perform these operations if the surgical exposure is so small, allowing only the priimary surgeon to see the majority of the surgery? What are the limits of this sort of surgical approach? These are amongst the questions posed to the first author of this work, Associate Professor of Surgery at University of Toronto, Dr. Christoph Haller. DOI: 10.1016/j.jtcvs.2025.12.009
"What used to be a once-a-year catastrophic claim is now happening every single week across the stop-loss market."We're back for the fourth year in a row with our annual whiteboard review of Tokio-Marine HCC's Stop Loss Report. Drawing from a massive block of over $2 billion in force premium, this report gives us one of the clearest, most objective looks at what is actually happening under the hood of self-funded health plans across the country.In this episode, I break down the biggest trends shaping the 2026 stop-loss environment. We look at the tightening stop-loss market, why underwriter discipline is ramping up, and why we likely won't see market stabilization until at least 2027.If you are a consultant, TPA, or plan sponsor trying to navigate renewals and protect your plan over the next 3 to 5 years, this breakdown is packed with actionable data. Tune in!Chapters:(00:00:00) Intro: 2026 Tokio Marine HCC Stop Loss Report Breakdown(00:01:25) The $2M Claim Spike & Tightening Stop-Loss Market(00:04:23) Catastrophic Claim Trajectory: $500K vs. $2M Thresholds(00:06:05) Top Disease Categories: Cancer, Cardiovascular & Nervous System(00:09:12) Analyzing Severity: $85 Million Across 30 Claims(00:14:43) Underwriting Mechanics: How Lag & Claims Data Impact Renewals(00:17:35) Evolution of Specific Deduuctibles & Optimal Risk Corridors(00:24:05) Pediatric Risk & High-Cost Perinatal/Neonatal Claims(00:28:57) How "Leverage Trend" Silently Inflates Your Premium(00:30:10) Mental & Behavioral Health Cost Trends (+123% Increase)(00:31:35) Macro Takeaways: IDR Arbitration, Cost Shifting, and 2027 Outlook
"What used to be a once-a-year catastrophic claim is now happening every single week across the stop-loss market."We're back for the fourth year in a row with our annual whiteboard review of Tokio-Marine HCC's Stop Loss Report. Drawing from a massive block of over $2 billion in force premium, this report gives us one of the clearest, most objective looks at what is actually happening under the hood of self-funded health plans across the country.In this episode, I break down the biggest trends shaping the 2026 stop-loss environment. We look at the tightening stop-loss market, why underwriter discipline is ramping up, and why we likely won't see market stabilization until at least 2027.If you are a consultant, TPA, or plan sponsor trying to navigate renewals and protect your plan over the next 3 to 5 years, this breakdown is packed with actionable data. Tune in!Chapters:(00:00:00) Intro: 2026 Tokio Marine HCC Stop Loss Report Breakdown(00:01:25) The $2M Claim Spike & Tightening Stop-Loss Market(00:04:23) Catastrophic Claim Trajectory: $500K vs. $2M Thresholds(00:06:05) Top Disease Categories: Cancer, Cardiovascular & Nervous System(00:09:12) Analyzing Severity: $85 Million Across 30 Claims(00:14:43) Underwriting Mechanics: How Lag & Claims Data Impact Renewals(00:17:35) Evolution of Specific Deduuctibles & Optimal Risk Corridors(00:24:05) Pediatric Risk & High-Cost Perinatal/Neonatal Claims(00:28:57) How "Leverage Trend" Silently Inflates Your Premium(00:30:10) Mental & Behavioral Health Cost Trends (+123% Increase)(00:31:35) Macro Takeaways: IDR Arbitration, Cost Shifting, and 2027 Outlook
What if some of the most powerful ways to improve your health didn't require expensive gadgets, complicated routines, or the latest supplement trend? In this rapid-fire solo episode, Darin shares 15 unusual, science-backed habits that can dramatically improve longevity, mobility, brain function, nervous system regulation, digestion, and overall vitality. From dead hangs and deep squats to humming, sunlight, boredom, and chewing your food more thoroughly, each practice is grounded in published research, not internet biohacking hype. These are simple, practical habits you can start today that may have an outsized impact on your health over time. If you're looking for evidence-based ways to optimize your body without spending a fortune, this episode is packed with actionable takeaways. What You'll Learn Why grip strength may be one of the strongest predictors of longevity How deep squats improve mobility and joint health The surprising connection between balance and lifespan Why humming boosts nitric oxide production The science behind mouth taping and nasal breathing How cold water can instantly calm your nervous system Why boredom fuels creativity and brain function The health benefits of intentional silence How awe can reduce inflammation Why soil microbes strengthen your immune system The importance of chewing for nutrient absorption Why sunlight is one of the most powerful daily health tools Chapters 00:00:00 – Welcome to SuperLife 00:00:32 – Sponsor: Tru Niagen 00:02:35 – 15 science-backed health habits you probably aren't doing 00:04:18 – #1 Grip strength and longevity 00:06:40 – #2 The deep squat rest 00:08:16 – #3 Single-leg balance 00:09:36 – #4 Why humming boosts nitric oxide 00:11:01 – #5 Mouth taping and nasal breathing 00:12:41 – #6 Cold water face immersion 00:14:05 – #7 Ice on the back of your neck 00:14:59 – Sponsor: Manna Vitality 00:16:55 – #8 Getting bored on purpose 00:18:34 – #9 Scheduling daily silence 00:20:01 – #10 Chasing awe instead of scrolling 00:21:20 – #11 Why getting your hands dirty boosts immunity 00:23:00 – #12 Chewing your food more thoroughly 00:24:20 – #13 Squatting while using the bathroom 00:25:41 – #14 Get sunlight before your phone 00:26:59 – #15 Sunlight on your skin 00:28:28 – The complete 15-step daily protocol 00:29:05 – Start with one habit today 00:29:26 – Final thoughts and closing message Thank You to Our Sponsors Tru Niagen: Boost NAD+ levels for cellular health and longevity. Get 20% off with code DARINOLIEN20 at truniagen.com. Manna Vitality: Go to mannavitality.com/ and use code DARIN for 20% off your order. Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Better health doesn't always come from doing more—it often comes from returning to the simple things humans have done for thousands of years. Move your body naturally. Breathe through your nose. Spend time in silence. Get into the sun. Touch the earth. Challenge your balance. Strengthen your grip. These aren't expensive biohacks—they're timeless biological signals that remind your body how to thrive. Small daily actions, repeated consistently, can create extraordinary long-term health." Bibliography/Sources Physical Function & Biomechanics Araujo, C. G., et al. (2022). Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals. British Journal of Sports Medicine https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2022.1066913/full Deep squat / ankle dorsiflexion as clinical mobility assessment. (n.d.). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC7276781/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12358486/ Leong, D. P., et al. (2015). Prognostic value of grip strength: Findings from the Prospective Urban Rural Epidemiology (PURE) study. The Lancet, 386(9990), 266–273. https://doi.org/10.1016/S0140-6736(14)62000-6 Sikirov, D. (2003). Comparison of straining during defecation in three positions: Results and implications for human health. Digestive Diseases and Sciences, 48(7), 1201–1205. https://doi.org/10.1023/A:1024180319005 Respiratory & Nervous System Effects of cold stimulation on cardiac-vagal activation in healthy participants: A randomized controlled trial. (n.d.). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC6334714/ Systematic review of mouth taping for sleep-disordered breathing. (2024). PLOS One. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0323643 Trigeminocardiac / mammalian dive reflex response to cold facial immersion. (2023). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC10295257/ Weitzberg, E., & Lundberg, J. O. N. (2002). Humming greatly increases nasal nitric oxide. American Journal of Respiratory and Critical Care Medicine, 166(2), 144–145. https://pubmed.ncbi.nlm.nih.gov/12119224/ Brain, Silence & Emotion Bartoli, E., et al. (2024). Default mode network electrical stimulation effects on creativity. Brain, 147(10), 3409+. Bernardi, L., Porta, C., & Sleight, P. (2006). Cardiovascular, cerebrovascular, and respiratory changes induced by different types of music in musicians and non-musicians: The importance of silence. Heart, 92, 445–452. https://pubmed.ncbi.nlm.nih.gov/16199412/ Mann, S., & Cadman, R. (2014). Does being bored make us more creative? Creativity Research Journal, 26(2), 165–173. https://doi.org/10.1080/10400419.2014.901073 Münzel, T., et al. (2024). Noise causes cardiovascular disease: It's time to act. Journal of Exposure Science & Environmental Epidemiology. https://pmc.ncbi.nlm.nih.gov/articles/PMC11876066/ Stellar, J. E., John-Henderson, N., Anderson, C. L., Gordon, A. M., McNeil, G. D., & Keltner, D. (2015). Positive affect and markers of inflammation: Discrete positive emotions predict lower levels of inflammatory cytokines. Emotion, 15(2), 129–133. Immune, Digestion & Environmental Light Cassady, B. A., Hollis, J. H., Fulford, A. D., Considine, R. V., & Mattes, R. D. (2009). Mastication of almonds: Effects of lipid bioaccessibility, appetite, and hormone response. The American Journal of Clinical Nutrition, 89(3), 794–800. https://pubmed.ncbi.nlm.nih.gov/19144727/ Liu, D., Fernandez, B. O., Hamilton, A., et al. (2014). Isolated UVA irradiation of human skin generates dermal nitric oxide and lowers blood pressure independent of vitamin D. Journal of Investigative Dermatology, 134(7), 1839–1846. https://pubmed.ncbi.nlm.nih.gov/24445737/ Morning light exposure and circadian phase-shifting / dim-light melatonin onset. (n.d.). PubMed Central. https://pmc.ncbi.nlm.nih.gov/articles/PMC10594521/ Rook, G. A. W., et al. (2023). The old friends hypothesis: Evolution, immunoregulation and essential microbial inputs. Frontiers in Allergy. https://pmc.ncbi.nlm.nih.gov/articles/PMC10524266/ Strachan, D. P. (1989). Hay fever, hygiene, and household size. BMJ, 299(6710), 1259–1260. https://doi.org/10.1136/bmj.299.6710.1259
In this episode, we review the high-yield topic of Direct-Acting Vasodilators from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Sturge-Weber Disease from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
Many of us hated them in gym class. The push-up won't make anyone's list…
Leveling Up: Creating Everything From Nothing with Natalie Jill
Before menopause, our risk of heart disease is HALF what a man's is. Within a few years of our last period, it is EQUAL. By our seventies, it is HIGHER. So why is nobody screening us for it? This is the conversation midlife women have been waiting for. I sat down with Dr. Jayne Morgan, a research cardiologist and Vice President of Medical Affairs at Hello Heart, who is calling out menopause itself as the most missed opportunity in preventive cardiology. She is the creator of the Stairwell Chronicles, a science communicator who translates complex cardiology into kitchen-table language, and she has spent 25+ years researching what is actually happening to our hearts in midlife. This is our fourth cardiologist on the show. And she is different. She brings the research, the data, and a fierce honesty about why our healthcare system was built around the male body, and what we do about it now. WE GO DEEP ON: • Why menopause is a CARDIOVASCULAR event, not a gynecologic footnote • The half / equal / greater stat that every midlife woman needs to memorize • The 37-minute delay women face in the ER for cardiac care, and the exact phrase that gets you seen • Why hot flashes, night sweats, palpitations, and brain fog are cardiovascular signals, not just inconveniences • What estrogen actually does for your heart and what happens when it drops, and the 10-year HRT window • Her take on statins, the online backlash, and what the research actually says about LDL • What to do if you tried a statin and felt terrible — • Why it is LDL AND insulin resistance AND inflammation — not one versus the other • The labs to demand: ApoB, Lp(a), hs-CRP, fasting insulin, CAC scan • Why women were excluded from cardiovascular clinical trials until 1993, and how that built the entire field on the wrong data • The exact advocacy phrase that gets your concern documented in your chart • Three things you can do this week that actually move the needle This is not a doom episode. This is the conversation you bring to your doctor tomorrow. TIMESTAMPS: • 00:00 — Why menopause is a cardiovascular event • 12:00 — The symptoms women miss and the 37-minute ER delay • 26:00 — Estrogen, HRT and the 10-year window • 42:00 — LDL, cholesterol and the statin debate • 54:00 — What to test, what to track, what to demand • 66:00 — Health equity and self-advocacy • 76:00 — Three things this week Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube Learn More About Dr. Jayne Morgan Instagram ➜ http://www.instagram.com/drjaynemorgan Website ➜ https://drjaynemorgan.com/ Hello Heart➜ https://www.helloheart.com/ Thank you to our show sponsors: LEELA QUANTUM: Get 10% off your first Leela Quantum order with the code NatalieJill at checkout at https://midlifeconversations.com/leela TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL BIOPTIMIZERS: Stop settling for one form of magnesium when your body needs all 7. This one has them all! Get yours at https://bioptimizers.com/nataliejill and use code NATALIEJILL to save Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit For advertising inquiries: https://www.category3.ca/ Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.
In this episode, we review the high-yield topic of Atrial Flutter from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
Quality improvement projects can be done in just about any setting--but what does the process look like?Guest Kate Lew, MSN, RN, FNP-C, shares her experience in the creation and completion of a QI project in her workplace. Learn about the steps and strategies that were used to identify the problem, access related data, and make recommendations for improvement.Resources:PCNA Abstracts: https://pcna.net/events-news/cardiovascular-nursing-symposium/call-for-abstracts/abstract-guidelines/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Professional development to improve nursing knowledge and skills occurs in a variety of forms. Learn from Sandra Klafter, BSN, RN, CV-BC, about her experience in preparing for the Cardiac-Vascular Nursing Certification (CV-BC) as well as her involvement in PCNA.CV-BC CredentialVolunteering with PCNASee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, we review the high-yield topic of Eisenmenger Syndrome from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Tetralogy of Fallot from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
In this episode, we review the high-yield topic of Transposition of Great Vessels from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
We are in the third week of our 4-part series on the 6th-leading cause of death in America. In this episode, we focus on the thorough diagnostics at Holistic Integration that reveal the root causes of brain deterioration. In this episode, you'll discover:—Why Dr. Prather believes there are more contributing factors to Alzheimer's than just the amyloid plaque theory. And the six factors or patterns that Dr. Prather looks for as potential underlying causes to Alzheimer's.—The SPECT imaging that is critical to any diagnosis of Alzheimer's. And the blood tests that can actually help to prevent deterioration of brain health if diagnosed early.—How a Cardiovascular workup is important for Alzheimer's and Dementia since you are more likely to develop Alzheimer's if you have Cardiovascular disease. —The surprising connection between a person's fingerprint patterns and Alzheimer's. —How proper levels of Vitamin D can help reduce your chances of developing Alzheimer's by 40%. And the importance of checking the B Vitamins and Iodine.—The reason that inflammation markers are "extremely important" for Alzheimer's. —How Alzheimer's is referred to as Type 3 Diabetes due to the impact of glycotoxic levels of blood sugar on the brain.—Why Dr. Prather says he would refuse to take on a patient with Alzheimer's or Dementia unless they agreed to do a Hair Analysis. And how a Hair Analysis shows your levels of heavy metals like Aluminum, which seems to be most associated with Alzheimer's and Dementia. —The "tremendous amount of changes" that Dr. Prather sees in emotional and brain health by balancing the Copper-Zinc ratio. —Why an annual stool kit is so essential because of the connection between gut health and brain function. And what the "research grade" Autonomic Nervous System or ANS Test at Holistic Integration reveals about your brain health .http://www.TheVoiceOfHealthRadio.com*Receive exclusive bonus content as a member of our Voice Of Health Patreon Community:https://www.patreon.com/cw/VoiceofHealthPodcast
Jaume Segalés y los expertos de Mundo Natural hablan sobre la salud cardiovascular.
In this episode, Randy Vawdrey dives into the world of hormone optimization, challenging decades of conventional wisdom that has stigmatized hormone therapy, especially for women.You'll hear an evidence-based exploration into the role hormones like DHEA, estrogen, progesterone, and testosterone play in cardiovascular prevention, brain health, and longevity. We'll unpack landmark studies, expose misconceptions rooted in outdated research, and share powerful stories and expert interviews that reveal how proper hormone management can transform lives.Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardioTIMESTAMPS: 00:00 Understanding DHEA and DHEA-S04:04 DHEA and cardiovascular health08:05 DHEA's role in heart disease12:24 Using DHEA for better health14:31 Discussing hormone treatments16:14 The impact of 2001 study21:39 Debunking hormone replacement myths25:19 FDA's stance on hormone therapy27:03 Doctor's views on hormone therapy30:21 Prescribing BHRT to older patients35:13 Closing remarks and resourcesSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
In this rapid-fire episode, Salvatore Brugaletta answers key questions on interventional cardiology, coronary imaging, bioresorbable scaffolds, vascular healing, and the future of percutaneous coronary intervention. From AI-assisted procedures to device innovation and career advice, this concise episode offers expert insight into the evolving world of coronary intervention.
Salvatore Brugaletta joins host Catherine Glass to explore how intracoronary imaging has transformed modern percutaneous coronary intervention (PCI). From intravascular ultrasound and optical CT to stent optimisation, vascular dysfunction, and AI-enhanced image interpretation, this episode examines the technologies improving procedural precision and patient outcomes. Timestamps: 0:55 – IVUS and OCT 2:58 – Endothelial recovery 4:55 – Stent failure mechanisms 6:19 – Barriers to adoption 8:18 – Innovations in imaging
In this episode, Faraz Ahmad, MD, associate director at the Center for Artificial Intelligence at Northwestern Medicine Bluhm Cardiovascular Institute, discusses how Northwestern is advancing AI strategy, developing clinical AI tools, and training the next generation of AI-focused healthcare leaders. He also shares insights on implementing AI responsibly through workflow redesign, evaluation, and collaboration.
This week we delve again into the world of adult congenital heart disease and specifically the realm of biomarkers when we review a recent report of the proteomics of the adult Fontan patient. What is proteomics and how can this inform our understanding of the pathophysiology and adaptive pathways of the Fontan circulation? Are there meaningful differences in the patterns of protein expression between the adult Fontan patient and control 2 ventricle subjects? What might account for differences and how can we understand these differences to explain outcomes in the Fontan adult patient? We speak with the first and senior authors of this week's work, Professor Alexander Opotowsky of the University of Cincinnati and Mr. Ismael Assi who is a Sarnoff Fellow and soon to be 4th year medical student at the University of Cincinnati. DOI: 10.1016/j.jacadv.2026.102810
Following on from surprise atherosclerosis in 2023 that resulted in 3 stents to resolve 2, 95% and 1, 90% arterial blockages, Tim adopted a carnivore diet as one of the known mechanisms to reduce inflammation, lower visceral fat and body fat, become fat adapted and improve gut health. After three months on the Carnivore diet, Tim's body weight had dropped 12KG from 82Kg to 70Kg and this provided Tim the confidence to stop taking statins and then fully tapered off gout medication (allopurinol). Timestamps: 00:00 Trailer 00:27 Introduction 06:08 Health insights and lifestyle reflections 09:41 Managing gout with diet and medication 11:18 Cardiovascular health and lifestyle changes 16:44 Discussing statin medication 18:07 Concerns about statins 23:36 Regular blood work and health monitoring 26:54 Training and personal growth 27:59 Feeling better on a Low-Carb Diet 33:52 Media influence on Dutch eating habits 35:16 Meat consumption and culture 39:43 Retirement in Greece 41:21 Dutch greenhouses and CO2 44:45 Health and social media Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs #Revero #ReveroHealth #shawnbaker #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.
MedAxiom HeartTalk: Transforming Cardiovascular Care Together
Cardiovascular ambulatory surgery centers (ASCs) are no longer a future concept — they are quickly becoming a critical part of care delivery. In this episode of MedAxiom HeartTalk, host Melanie Lawson talks with Jerry Blackwell, MD, MBA, FACC, president and CEO of MedAxiom, and Aric Burke, founder and CEO of Atlas Healthcare Partners, about the momentum behind cardiovascular ASCs and the role MedAtlas CV is playing in advancing this transformation. Together, they explore how the right clinical expertise, operational model and physician alignment can help health systems deliver high-quality, efficient and lower-cost cardiovascular care in the outpatient setting.
On today's Good Day Health Show - ON DEMAND…Host Doug Stephan and Dr. Ken Kronhaus of Lake Cardiology (352-735-1400) cover a number of topics affecting our health. First up, Doug and Dr. Ken discuss the latest developments in medicine, technology, and preventive healthcare. The conversation explores how artificial intelligence is transforming medical diagnosis and disease prevention, allowing healthcare providers to identify health risks earlier and deliver more personalized patient care. Dr. Ken also examines advances in cardiovascular risk assessment, highlighting new tools and strategies that can help prevent heart disease before symptoms develop. The episode takes a closer look at the relationship between vaccinations and heart health, along with emerging research on neurogenesis and the brain's ability to adapt and form new neural connections throughout life. Dr. Ken discusses the importance of maintaining brain health as we age, including the benefits of treating hearing loss with hearing aids to support communication, cognitive function, and social engagement. Listeners will also hear updates on weight-loss strategies, including both prescription medications and natural supplement options, as well as a discussion of statins and alternative cholesterol-lowering therapies for cardiovascular protection.Rounding out the episode, Dr. Ken provides an update on current COVID-19 variants and vaccination strategies while emphasizing the importance of individualized healthcare decisions. Throughout the conversation, he highlights the everyday lifestyle choices—including nutrition, exercise, sleep, and social connection—that play a critical role in protecting brain health, reducing disease risk, and promoting healthy aging. Together, these topics offer listeners practical guidance and the latest medical insights for improving long-term health and wellness. For more on Good Day Health…Website: GoodDayHealthShow.comSocial Media: @GoodDayNetworks
Around 4% of the global population has aortic stenosis, and early identification is key to reducing strain on the heart and reducing morbidity and mortality. Guest Alicia White, MSN, RN, describes signs and symptoms, diagnosis, treatment, and follow-up care following procedures.Related PCNA CE course:Aortic Stenosis: An increasing risk for structural heart disease: https://pcna.net/course/aortic-stenosis-an-increasing-risk-for-structural-heart-disease/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Advanced practice providers (APP) provide both quality care and leadership in structural heart interventions. Guest Caitlin O'Callaghan Reen, CNP, FACC, describes how to effectively work with patients and their support communities in shared decision-making for long-term, lifetime planning, and leadership within the structural heart team.Related PCNA CE Course: Structural Heart Interventions: What's New?See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Featuring an interview with Dr Rana R McKay, including the following topics: Prostate Cancer Working Group (PCWG4) revised terminology (0:00) Cardiovascular effects associated with GnRH agonists versus antagonists; mechanism of action (2:17) Combination therapy using relugolix; factors affecting persistence and adherence to GnRH agents (12:06) Takeaways from the Phase III EMBARK study (19:36) Use of CAR (chimeric antigen receptor) T-cell therapy and T-cell engagers (27:20) Potential role of circulating tumor DNA minimal residual disease testing; use of olaparib/radium-223 (29:24) CME information and select publications
En este podcast, el cirujano cardiovascular de Salinas Valley Health, el Dr. Jamil Matthews, habla sobre el sistema cardiovascular y el papel fundamental que desempeña en nuestra salud general.#SistemaCardiovascular #Salud #Pódcast #AskTheExperts #SalinasValleyHealth
Dr. Hoffman continues his conversation with Neil Levin, the Senior Nutrition Education Manager and a product formulator for NOW(r) Foods and Protocol for Life Balance.
Cardiovascular Protection Beyond Statins--Nattokinase, Vitamin K2 MK-7, and Clinical Cardio Six: Neil Levin of NOW Foods/Protocol for Life Balance details cardiovascular protection beyond cholesterol-lowering drugs, emphasizing nutrient sufficiency, therapeutic “nutraceutical” dosing, and physician partnership with testing. They discuss nattokinase from fermented natto (typical 2,000 fibrinolytic units/day), describing research on reduced fibrinogen, improved blood viscosity and microcirculation, blood-pressure normalization, and higher-dose data suggesting benefits for arterial thickness and lipids without excessive blood-thinning. They review vitamin K: K1 for normal coagulation (risk with Coumadin relates to day-to-day variability) and K2 for calcium metabolism, highlighting MK-7's longer half-life and potency versus MK-4 and recommending pairing K2 with vitamin D. Levin outlines PFLB Clinical Cardio Six (D3, L-carnitine, hawthorn leaf/flower, solubilized grape seed extract, CoQ10, MK-7), ingredient sourcing/testing, omega-3 benefits, red yeast rice context, and controversy around vitamin E meta-analyses.
Host: Darryl S. Chutka, M.D. Guest: Regis Fernandes, M.D. We've known for some time that patients who have hypertension and diabetes are at increased risk for developing subsequent cardiovascular disease and chronic kidney disease. It's now being thought that these health problems are related and interconnected, representing Kidney-Cardiovascular Metabolic Syndrome. They form a pathophysiologic triad driven by shared mechanisms where disease in one system accelerates dysfunction in the others. So, what does this mean for primary care clinicians? Traditionally, we've managed hypertension, diabetes, cardiovascular disease, and chronic kidney disease as separate health conditions. It's now felt that there may be a better approach. The topic for this podcast is “Kidney-Cardiovascular Metabolic Syndrome”, and my guest is Dr. Regis Fernandes, a preventive cardiologist at the Arizona campus of the Mayo Clinic. We'll discuss the science, clinical implications, and recommended management strategies for this health condition. Connect with us! Mayo Clinic Talks Podcast Season 6 | Mayo Clinic School of Continuous Professional Development
The intersection of risk factors for diabetes, obesity, hyperlipidemia, the liver, and the cardiovascular system is becoming increasingly evident, and so is the mult-system impacts of lifestyle and specific pharmacotherapies for prevention and treatment. Episode guests Joseph Saseen, PharmD, MNLA, FACC, CLS, and Emily Bankhead, MSN, FNP-BC, describe the positive impacts of healthcare professionals working collaboratively, and to the top of their scope of licensure, to effectively address multi-system disorders.Related Resources2026 Multi-Society CKM Guideline [released after this episode recording]PCNA CE Course: Cardiometabolic Treatments for ObesitySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
How can nurses and other healthcare professionals help patients with diabetes and other cardiometabolic conditions reduce their risk of CVD? Join guests Joseph Saseen, PharmD, MNLA, FACC, CLS, and Emily Bankhead, MSN, FNP-BC, for a discussion about applying current guidelines for hypertension and glucose-lowering therapies and the importance of team-based care.Related Resources:2025 AHA/ACC High Pressure Guideline2026 Multi-Society CKM Guideline [released after this episode recording]PREVENT EquationsPCNA CE Course: Cardiometabolic Treatments for ObesitySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
With Antonia Sambola and Javier Limeres Freire, University Hospital Vall d'Hebron, Barcelona - Spain. Link to European Heart Journal paper Link to European Heart Journal editorial
Episode #73 — Rucking 101, with Dr. Franklin Muntis, PhD, RD, CSSD Guest Bio Dr. Franklin Muntis, PhD, RD, CSSD, is a registered dietitian and an officer in the United States Army. At Brooke Army Medical Center, he provides evidence-based nutrition education and counseling to improve the health and performance of military service members, retirees, and their families. Franklin is also a Certified Specialist in Sports Dietetics (CSSD), an NSCA Certified Strength and Conditioning Specialist (CSCS), and a Tactical Strength and Conditioning Facilitator (TSAC-F). His unique background in nutrition, strength and conditioning, and tactical performance gives him a comprehensive perspective on how nutrition and physical training work together to optimize performance, recovery, and long-term health. Description In this episode of the Elevate Yourself podcast, Rob welcomes back Dr. Franklin Muntis for a practical introduction to one of the fastest-growing fitness trends: rucking. Drawing from his experience as an Army officer, sports dietitian, and strength and conditioning specialist, Franklin explains what rucking is, why it has long been a cornerstone of military training, and why it's becoming increasingly popular among recreational exercisers. The conversation explores the physical and mental benefits of rucking, how beginners can safely get started, common mistakes to avoid, and the equipment you actually need. Franklin also shares evidence-based nutrition strategies to support performance and recovery, including hydration, fueling, protein intake, and practical tips anyone can apply. Whether you're looking for a new fitness challenge, a low-impact way to build strength and endurance, or simply want to understand the science behind rucking, this episode provides an excellent place to start. Topics Covered Franklin's journey as an Army officer, sports dietitian, and tactical performance specialist What rucking is and the history behind military load carriage Why rucking has become increasingly popular beyond the military The unique fitness benefits of rucking How beginners can safely incorporate rucking into their routine Common mistakes to avoid when starting Equipment recommendations and whether specialized gear is necessary How rucking compares to walking, running, and traditional cardio Nutrition strategies to support rucking performance Hydration and electrolyte considerations Protein and recovery after longer rucks Lessons from military performance that apply to everyday fitness Learn More Brooke Army Medical Center National Strength and Conditioning Association (NSCA) Academy of Nutrition and Dietetics – Sports, Cardiovascular, and Wellness Nutrition (SCAN) The Elevate Yourself Podcast is brought to you in partnership with Athletic Brewing. Use code ELEVATE30 for 30% OFF your first online order at checkout!
Most people know sauna is good for them. Far fewer understand why, or why the difference between a generic infrared sauna and a precision-engineered one can be the difference between feeling good and genuine transformation. In this episode of Why Isn't Everyone Doing This?, Emily Fletcher sits down with Connie Zach, co-founder of Sunlighten, for a science-grounded, story-rich conversation about the healing power of heat and light. Connie traces the origin of her 25-year mission to her brother's recovery from mercury poisoning, and the cardiovascular research she was quietly encountering while working in pharmaceutical development at Procter & Gamble. What she found convinced her that infrared sauna was one of the most underutilized healing technologies on the planet. Together, Emily and Connie break down the four wavelengths of the infrared spectrum, why each interacts with the body differently, and why Sunlighten's patented approach to separating and delivering those wavelengths produces results that general infrared products don't. They also share the transformation stories that have fueled Connie's work for decades: Leanne Rimes managing severe anxiety with what she calls her "happiness in a box," a woman named Jerry who went from being unable to climb stairs to moving freely again, and elderly patients who dramatically increased their exercise capacity through passive infrared therapy. Emily shares why infrared sauna is one of only two wellness practices she would take with her to a desert island, and what it feels like to combine daily meditation with consistent sauna use for nervous system support. In this episode, they explore: – The four wavelengths of the infrared spectrum and how each one interacts with the body – Why far infrared is the foundation of all infrared therapy and how it triggers cardiovascular conditioning – Near infrared's deep penetration capacity, and why Dr. Glenn Jeffrey at University College London says it does 90% of the heavy lifting in light therapy – Japan's Waon therapy: a first-line treatment for congestive heart failure showing a 50% reduction in hospitalization and death – How infrared sauna mimics passive exercise by increasing circulation, heart rate, and blood flow – The link between stagnant circulation and disease, and why consistent heat therapy keeps the system flowing – Connie's brother's recovery from heavy metal toxicity and the pharmaceutical research that changed everything – Why all infrared is not the same, and what to look for in a sauna if transformation is the goal – Leanne Rimes, chronic anxiety, and "happiness in a box" – What changes on the planet when more people have access to this level of recovery Key Moments: 00:00 – Why isn't everyone understanding the magic of heat and light? 05:09 – Introducing Connie Zach and Sunlighten 06:51 – The infrared spectrum: four wavelengths, four different effects 10:40 – Near infrared vs. red light: what actually penetrates the deepest 16:05 – Connie's origin story: her brother's healing from mercury poisoning 18:27 – Cardiovascular research that changed Connie's path out of pharma 20:23 – Infrared as passive cardiovascular conditioning 21:41 – Waon therapy in Japan and the 50% hospitalization reduction 24:15 – The elderly exercise capacity study 27:36 – Emily on circulation, stagnation, and disease 35:00 – Deathbed slideshow: the transformation stories 37:22 – Leanne Rimes: "happiness in a box" 41:10 – Dr. Jeff Spencer and the Sunlighten Solo 44:57 – What changes when a billion people use heat and light About Connie Zach Connie Zach is the co-founder of Sunlighten, a precision infrared sauna company with over 25 years of research-backed innovation. Her patented SoloCarbon technology is the only clinically studied full-spectrum infrared available. This episode is sponsored by Sunlighten. Save up to $2,100 + free shipping at get.sunlighten.com/zivapodcast
Episode 85 Part 2/2. Cardiovascular disease is often thought of as a heart problem, but its effects reach far beyond the cardiovascular system. In this episode, Dr. Gavin Guard explores the root causes of cardiovascular disease through a functional medicine lens, breaking down how chronic inflammation, metabolic dysfunction, nutrition, and lifestyle choices influence long-term heart health. You'll learn how cardiovascular disease develops, the warning signs to watch for, and the connection between factors like high blood pressure, cholesterol imbalances, insulin resistance, and overall wellness. Dr. Holthouse also discusses evidence-based strategies for reducing risk and improving healthspan through personalized care and preventive medicine. Whether you're looking to better understand your cardiovascular risk, support a loved one, or take proactive steps toward a healthier future, this episode provides practical insights and actionable takeaways grounded in current science. In this episode, you'll learn: What cardiovascular disease is and why it's so common How inflammation contributes to heart disease The relationship between cholesterol, blood pressure, and cardiovascular risk Why metabolic health plays a major role in heart health Functional medicine approaches to prevention and treatment Lifestyle strategies that support a healthy cardiovascular system Steps you can take today to reduce your risk of heart attack and stroke Stay tuned in for more conversations on functional medicine, preventive healthcare, longevity, and optimizing your health from the inside out!
In this episode, we review the high-yield topic of Cardiac Tamponade from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
This week we talk about LDL, HDL, and cardiovascular issues.We also discuss one-time therapies, statins, and pharmaceutical economics.Recommended Book: Blood by Dr. Jen GunterTranscriptCholesterol is the most common type of what's called a sterol, which is a type of steroid, but also structurally technically an alcohol. But functionally, and classified by scientists, cholesterol is a lipid, which in this case is similar to a fat in all but how the body uses it. Cholesterol is the type of sterol most commonly found in animals—other types are found in plants and fungi—and its function, and this is where it varies from fats, which are used to store energy, is to basically help hold the cell membrane together, and it also serves as an intracellular messenger.Cholesterol is especially prevalent in the brain and spinal cord of animals, but it's found throughout their bodily tissues, as well, and again, it's vital for holding everything together and helping things communicate, in addition to being a precursor for vitamin D, steroid hormones, and bile.You want to have cholesterol, then, as without it you would be dead.Too much cholesterol in the blood, however, can also make you dead, especially when it's bound to what's called low-density lipoprotein, or LDL, as that contributes to cardiovascular disease like heart attacks and aneurysms, which can massively impact one's overall wellness and quality of life, and at extremes lead to the whole system shutting down as a consequence of heart attack, stroke, and the like.A lot of things can contribute to the development of cardiovascular disease, including habits like smoking, genetic predisposition, and the enthusiastic consumption of alcohol and unhealthy foods. But high blood cholesterol, of the LDL variety, is one of the top contributors, as these low-density clusters of lipoprotein can clog the pathways that blood takes throughout our bodies. Other, denser types of lipoproteins, HDLs, can clear it, like a heavier, denser substance pushing through clogs of less-dense materials that are gumming up a pipe, but LDL is at times accumulated as a result of consuming delicious but unhealthy foods, which are hard to avoid, and for some people the only consistently available and affordable foods; and for other people LDL accumulates as a result of their genetic predispositions—two things that are devilishly difficult to change.What I'd like to talk about today is a new type of therapy that may be very good news for people who struggle with the accumulation of LDL, and why this is being seen as very good news more broadly, at the scale of entire nations, as well.—Pharmaceutical company Eli Lilly is testing a new, experimental drug called VERVE-102 which is a one-time infusion that is currently administered over the course of about four hours, and once completed, it turns off a gene called PCSK9, which is responsible for making a protein that regulates cholesterol levels in humans.As I said, this drug is still being tested, so these are early results. But in a study of 35 people with high cholesterol levels, high levels of LDL or LDL-C, which is short for lipoprotein cholesterol, they found that this infusion, which again, is a one-time treatment, so get it once and then theoretically at least you never have to get anything done ever again, it reduced those LDL and LDL-C levels by as much as 62%, and that reduction was maintained a year and a half after the infusion; that's how far out they're retested so far, and the hope is that each retest will continue to show the same.On the strength of those very promising results, a Phase 2 study has been planned by the end of 2026, and the US Food and Drug Administration, the FDA, previously fast-tracked this existing study, because of the promise and potential this drug already demonstrated in early studies; all of which is considered to be very significant progress and possibility.To understand that significance, though, it's useful to know some health stats. And I'm going to focus on the US here, as that's where this drug is being developed, but many wealthy countries have similar stats, at least in terms of cardiovascular disease struggles.As of 2024, which is the last year we had good, cohesive data on this in the US, it was estimated that about 11-12% of the US adult population has high cholesterol levels. This typically doesn't come with any symptoms, but it can contribute a higher risk for all those cardiovascular diseases, including heart attack and stroke. A further 86 million US adults have borderline or elevated cholesterol levels, which can easily tip higher, but also, even in that existing, elevated state, contribute to negative cardiovascular outcomes.There are treatments for high cholesterol, the most common of category of which are called statins, which reduce the production of LDL by inhibiting an enzyme that produces cholesterol in the body.Unfortunately, these drugs do come with some usually minor side effects, which can cause patients to stop using them, and they have to be taken daily, ideally at the same time each day. That necessity for consistency leads to a lot of incorrect or incomplete usage, which reduces the effectiveness of these drugs. But it's also estimated that only about 54.5% of US adults who would benefit from statins are currently taking one—so that's people who could benefit and who have it prescribed, and then within that number are all the people who are taking this drug incorrectly or incompletely, reducing the effectiveness. So a relatively small number of people who should probably be on these things are getting the full benefit they offer because of the nature of the drug.And that's not great, because in the US alone, heart disease is the leading cause of death for pretty much every adult demographic; men, women, people of most racial and ethnic and economic groups, you name it, heart disease is the biggest threat to their lives.One US citizen dies every 34 seconds of some kind of cardiovascular condition, and as of 2023, 1 in every 3 deaths in the US was caused by the same, adding up to just over 919,000 people that year.Between 2021 and 2022, alone, the cost of services and medications related to heart disease added up to more than $168 billion; again, that's just in that period, and just in the US.And once more, these are ailments that are caused or heavily influenced by high levels of cholesterol, which are themselves amplified by common lifestyle choices, environmental factors that are hard for many people to avoid, and just by raw, dumb luck because of genetics.This treatment category, then, is being seen as a pretty big deal because a one-time infusion means those who receive it don't have to remember to take a pill every day at the same time, and won't experience those statin-based side-effects.It also means that people who are currently costing the medical system a bunch of money each year, because they need treatments for all the issues they suffer as a result of high cholesterol, will suddenly cost the system a lot less money, for treatments and medications. Not for nothing, their health and quality of life will likely improve as well. So in addition to having better, healthier outcomes personally, their cost to healthcare systems will drop.Eli Lilly's drug isn't the only one currently working its way through clinical trials, either.Amgen is working on a similar treatment, and Novartis and Ionis Pharmaceuticals have drugs that are even further along in the process, their medicines that cut heart attacks, strokes, and cardiovascular deaths could be approved by the FDA as soon as next year.There are a lot of caveats worth noting here, including that the science is still out as to whether this approach, silencing proteins that lead to the creation of more LDL and a similar substance called Lp(a)—which is more dangerous because it's stickier and thus more likely to get stuck in important blood pathways, and it's also more likely to be caused by genetics than lifestyle—the word is still out on whether reducing these things in the body actually reduces hearth attacks and stroke.Some people have had this particular risk variable dramatically reduced, but have still suffered from cardiovascular events, which raises the question of whether this path is the right one to take in trying to reduce this category of health issues; the correlation between LDL and heart attacks and strokes might not be a clear-cut as long assumed.There's also the issue of price. Drug-makers are economically incentivized to sell treatments over cures, because that means they can continue selling their product over time, potentially for the life of the patient, and a cure, in contrast, is a one-time hit that in theory should alleviate the need for future treatment.There's a chance, then, that the drug-makers will decide they need to make these one-hit treatments really, really expensive in order to make their R&D dollars back and to make the kinds of profits their investors expect from them. That could then reduce the potential audience for these treatments, even if they are effective, and could further slow their deployment and future research in this space.If these trials continue to go well, though, there's a good chance that this combination of similar but distinct treatment types will provide a more sustainable alternative to current options, and that, like the recent bogglingly rapid and widespread deployment of GLP-1 treatments for all sorts of issues, could lead to a new paradigm in this facet of the medical world.Show Noteshttps://en.wikipedia.org/wiki/Cholesterolhttps://en.wikipedia.org/wiki/Cardiovascular_diseasehttps://en.wikipedia.org/wiki/High_cholesterolhttps://pmc.ncbi.nlm.nih.gov/articles/PMC10982736/https://www.cdc.gov/heart-disease/data-research/facts-stats/index.htmlhttps://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1https://www.ama-assn.org/public-health/chronic-diseases/what-doctors-want-patients-know-about-high-cholesterolhttps://en.wikipedia.org/wiki/Statinhttps://pubmed.ncbi.nlm.nih.gov/42187087/https://abcnews.com/GMA/Wellness/new-drug-game-changer-people-high-cholesterol/story This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe
I am delighted to have the privilege of reconnecting with Dr. Deb Matthew today. She joined me once before on Episode 259. She is a distinguished best-selling author, international speaker, and dedicated educator known as the Happy Hormone Doctor. Cardiovascular disease is the number one killer of women in the United States, causing one of every 3.2 deaths among women annually. In our conversation today, Dr. Matthew and I delve into the realm of cardiovascular disease, exploring the benefits of hormone replacement therapy, essential laboratory testing, medications, and the neurocognitive changes that occur during perimenopause and menopause. We also focus on lifestyle, gut testing, and the all-time favorite topic: weight-loss resistance. Stay tuned for today's engaging, enriching, and enlightening discussion with Dr. Deb Matthew. IN THIS EPISODE YOU WILL LEARN: How HRT reduces the risk of cardiovascular disease How long-term use of estrogen can reduce the risk of heart disease over time Why you should do a hormone panel before starting HRT How cortisol levels impact cardiovascular health How the coronary calcium score helps to predict heart attack risk Cholesterol markers and their significance in cardiovascular risk assessment Managing cholesterol levels in perimenopausal women The importance of addressing underlying hormonal imbalances in women to mitigate cognitive decline and lipid disorders The connection between gut health and brain fog How women's testosterone levels impact their cognition and motivation Hormone imbalance and weight loss resistance in women Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Deb Matthew On her website Facebook Instagram Dr. Deb Matthew's book This is Not Normal on Amazon Previous Episode featuring Dr. Matthew Ep. 295: HRT's Impact on Women's Health Through Time with Dr. Deb Matthew
Federico y el Dr. Enrique de la Morena hablan con el Dr. Borja Ibáñez, director científico del Centro Nacional de Investigaciones Cardiovasculares.
In this episode, we review the high-yield topic of Orthostatic Hypotension from the Cardiovascular section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets