RADIOactive Podcast

Today's podcast is hosted by Julie Costanzo, PhD and features Roger W. Howell, PhD and Jean-Pierre Puget, PhD as they discuss challenges in cancer treatment. This conversation was facilitated at the Radiation Research annual meeting 2018.

Ye Yuan, Physician/Scientist, currently working in the Radiation Oncology department at UCLA Medical Center discusses his career path and current research.

Walter Tinganelli is a highly qualified biotechnologist, with an outstanding academic history and international research experience at several major radiation biology research centers. John Earley interviews Dr. Tinganelli who discusses his career path and current research.

Carissa Ritner, Northwestern University, discusses her research on neuroblastoma, radiation resistance, miRNA.

Dr. Amrita Cheema, Departments of Oncology and Biochemistry; Co-Director: Waters Center of Innovation in Metabolomics, Georgetown University Medical Center, discusses her research.

Dr. Francis A. Cucinotta, University of Nevada, Las Vegas, discusses his 2018 Failla Award Lecture – "Adaciu Adaciu si fa Gran Viaggiu: With a Heavy Ion Accelerator you can Travel to Mars."

Dr. Katherine L. Morel, currently working at the Dana-Farber Cancer Institute, discusses her Radiation Research Editors’ Award article. “Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo” Radiat Res187, 501-12 (2017). https://bioone.org/journals/radiation-research/volume-187/issue-5/RR14710.1/Parthenolide-Selectively-Sensitizes-Prostate-Tumor-Tissue-to-Radiotherapy-while-Protecting/10.1667/RR14710.1.short  

Dr. Pierre Montay-Gruel is one of the pioneers studying FLASH radiation. He began his work at the University of Lausanne, Switzerland in Dr. Marie-Catherine Vozenin's lab. There, he studied FLASH effects on the brain and glioblastoma in mice. He is now expanding his research at the University of California- Irvine with Dr. Charles Limoli.

Additional links featured in this podcast: NIAID: “Concepts: Potential Opportunities”: https://www.niaid.nih.gov/grants-contracts/potential-opportunities  NIH Videocast: https://videocast.nih.gov/  NIAID - subscribe to receive emails: https://service.govdelivery.com/accounts/USNIAID/subscriber/qualify  NIH - Radiation Research program:  https://rrp.cancer.gov/default.htm  NIH SBIR and STTR Programs: https://sbir.nih.gov/  NASA Solicitation and Proposal Integrated Review and Evaluation System: https://nspires.nasaprs.com/external/  NIAID Contracts Standard Operating Procedures (SOPs) & resources: https://www.niaid.nih.gov/research/contracts-sops-resources  NASA Human Research Program: https://www.nasa.gov/hrp  

FLASH: Charles Limoli, PhD and Marie-Catherine Vozenin, PhD, are interviewed on the surprising effects, how the idea came to fruition and the future of the therapy.

Allyson Koyen, BS, Cancer Biology Graduate Program, Emory University, working in David S. Yu, MD/PhD, Laboratory, discusses her current work.

Steven McMahon, PhD, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, discusses his current work.

Claire Isabelle Vanpouille-Box, PhD, Weill Cornell Medicine, Radiation Oncology Department, New York, NY, discusses her current work.

M. Waleed Gaber, PhD, from the Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine discusses the topic of mentorship in science.

Claire Rodriguez-Lafrasse from Lyon-Sud Medical School, Laboratory of Cellular and Molecular Radiobiology discusses her current work.

Dr. Leon Sanche from the University of Sherbrook, Department of Nuclear Medicine and Radiobiology discusses his current work.

Dr. Julie Constanzo from Institut de Recherches en Cancérologie de Montpellier discusses her current work.

Dr. Jan Schuemann from Massachusetts General Hospital, discusses his current work.

  Dr. Nils-Petter Rudqvist from Weill Cornell Medicine. His research project is focused on investigating the mechanisms whereby radiation therapy can convert a tumor into an in situ individualized vaccine. In particular, Dr. Rudqvist is leveraging his multidisciplinary background to determine to which extent radiation effectively exposes the tumor neoantigen reservoir to the immune system.

 A conversation with Thomas Berger from German Aerospace Center (DLR) | Institute of Aerospace Medicine. Dr. Berger leads the Biophysics group that is conducting an investigation of the radiation environment in civil airflight altitudes, in low-earth orbits, during interplanetary cruise and on planetary surfaces.  

Frederico Kiffer is doctoral student at the University of Arkansas for Medical Sciences. His work focuses on the effects of space radiation on cognition and hippocampal morphology

Captain Christopher Cassidy, NASA Astronaut, details his time in space in an exclusive interview with the Radiation Research Society. From launch to landing, perks and perils, Captain Cassidy shares all!

A 2017 interview with Dr. Charlie Maitz with the University of Missouri, School of Medicine and College of Veterinary Medicine shares how he found himself in veterinary radiation oncology, his recent work and the role the Radiation Research Society has played in his career.

A 2016 interview with Iris Eke. She began her career in medical school and moved to basic science after completing her thesis in radiation. Now a post-doc at NCI, Dr. Eke's primary focus is radiation therapy-induced targets.

A 2016 Inteview with Dr. Olga Martin, radiation biologist at Peter MacCallum Cancer Center. She has a long history in radiation research. Beginning in basic science, Dr. Martin has transitioned to applicable uses. Watch to learn how she uses her past research in her present work, as well as projects she is currently working on.

A 2016 interview with Jai Smith, of Peter MacCallum Cancer Center. He discusses his project in DNA binding to create a compound to aid in the protection of normal tissue in head and neck cancers.

A 2016 interview with Radia Tamarat, PhD, of the Institute of Radioprotection and Nuclear Safety. she discusses her research of the use of stem cell therapy to treat patients after normal tissue damage due to radiation exposure.

A 2016 interview with Maureen Aliru, MD-PhD student at MD Anderson. She shares her project from Sunil Krishnan's lab. The project uses gold nanoparticles, a known radiosensitizer, in the cell's nucleus. The lab hopes to use the information to help determine better decisions concerning radiation and dose.

A 2016 interview with Stephen McMahon, PhD, of Queen's University Belfast, discusses his work in predicting radiation sensitivity from phenotypic characteristics. His lab, with the goal of building better models, focuses primarily on DNA damage and repair.

An 2016 interview with Sijumon Kunjacha, PhD, of the Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School discusses his study of a dual-targeting strategy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome than targeting the cells alone

A 2016 inteview with Christin Glowa from the German Cancer discussing the unique aspects of her research and facility, and how it applies clinically.

A 2016 interview with Stacy Muise, MSc, where she discusses her work with the ICCU at Flinders University in Australia. The lab Muise works in is researching the possible affects of clinical radiation on lungs and the immune system.

A 2016 interview with Michael Abend, MD, MSc. Abend leads a research group at the Bundeswehr Institute of Radiobiology in Munich. Dr. Abend details their work with blood samples of irradiated non-human primates and the importance of their findings on a global scale.

A 2016 interview with Emil Schueler. Schueler a medical physicist,  currently studying at Stanford University, discusses his work with ultra-high dose, "flash" radiation.

A 2016 interview with Alba Gonzalez Junca from UCSF.  Dr. Gonzalez Junca explains her research of epithelial-mesenchymal transition (EMT). Gonzalez Junca discusses how her research builds on previous studies and gives greater insight into how we can better understand EMT phenotypes.

A 2016 interview with Sebastian Oeck: "Clinically relevant protein Kinase B."

A 2016 interview with Jody Belz: "Slow release docetaxel in brachytherapy."

A 2016 interview with Aashish Soni: "PARP inhibitor in radiotherapy."

A 2016 interview with Daniel Adjei: "Design, characterization and application of a desk-top laser plasma x-ray source for radiobiology studies."

An interview with the 2015 Failla Memorial Lecture award winner, Albert Fornace: " The Expanding Scope of Radiation Stress Signaling."

A 2016 interview with Gayle Woloschak.

A 2016 Interview with Benjamin Blyth: "The paradox of adaptive response and iso-effect per fraction."

A 2016 interview with Silvia Formenti: 'Potential of radiation therapy to convert tumor into an "in situ" vaccine.'  

A 2016 interview with Wendy McGuiness: "Effects on combined immune and radiation cancer therapy on measures of anxiety in murine model."

A 2016 interview with Meetha Medhora. Functional imaging as an early biomarker of radiation pneumonitis.

A 2015 interview with Sijumon Kunjachan: "Nanoparticle mediated tumor vascular disruption: A novel strategy in radiation therapy."

A 2015 interview with Angela Groves regarding her work with pulmonary exposure to radiation results in an altered T-cell microenvironment in mediastinal lymph nodes.

A 2015 interview with Rao Papineni discussing the topics of cancer therapy and radiobiophotonics.

A 2016 interview with Chris Thome, Jake Pirkkanen, Andrew Zarnke from Northern Ontario School of Medicine Medical Sciences discuss the SNOLAB, an underground science laboratory specializing in neutrino and dark matter physics. Located 2 km below the surface in the Vale Creighton Mine located near Sudbury Ontario Canada, SNOLAB is an expansion of the existing facilities constructed for the Sudbury Neutrino Observatory (SNO) solar neutrino experiment.

A 2015 interview with Pavlina Todorova: "Assessment of brain tumor risk from charged particles using genetically-engineered mouse models."

In 2015, Dr. Julie Constanzo interviews Dr. Olivia Kelada about her recent graduation, research topics and the future of hyperfractionation and tissue hypoxia.