Podcasts about MSC

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: CRISPR modified cell transplant for type 1, risk of T1D if parent has a different type of diabetes, Metformin and the brain, oral GLP-1, and more! Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom   Check out VIVI Cap to protect your insulin from extreme temperatures The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links: Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX A 42-year-old man who has lived most of his life with type 1 diabetes has become the first human to receive a transplant of genetically modified insulin-producing cells. This marks the first pancreatic cell transplant in a human to sidestep the need for immunosuppressant drugs. “This is the most exciting moment of my scientific career,” says cell biologist Per-Ola Carlsson of Uppsala University in Sweden, who helped develop the procedure. The new treatment, he says, “opens the future possibility of treating not only diabetes but other autoimmune diseases.” This procedure uses the gene editing technique, CRISPR, to discourage the auto immune attack on the donor cells. Before the transplant, the participant had no measurable naturally produced insulin and was receiving daily doses of the hormone. But within four to 12 weeks following the transplant, his levels rose slightly on their own after meals—showing that the new beta cells were releasing some insulin in response to glucose. even though the new study is promising, it involved just one participant and is therefore preliminary. And longer-term monitoring is needed to confirm the therapy's safety before it can be offered to more people. She also notes that the injected cells produced only 7 percent of the insulin needed for a person to be fully independent of additional medication. The researchers supplied the recipient with insulin doses to maintain healthy blood sugar levels. While Herold thinks it's still too early to consider this approach for a cure, “these options are now here to change the disease in ways that have never been possible before,” he says. “There's tremendous hope.” https://www.scientificamerican.com/article/type-1-diabetes-patients-insulin-production-restored-with-new-cell/ XX   This one is interesting… a recent study shows that children of mothers with gestational diabetes or fathers with type 2 diabetes have higher chances of developing type 1 diabetes than kids whose parents do not have any type of diabetes. Specifically, the study found that children whose mothers had gestational diabetes during pregnancy were 94% more likely to develop type 1 diabetes compared to children of mothers without diabetes. Similarly, having a father with type 2 diabetes was linked to a 77% higher risk. The study also suggests a possible link between maternal type 2 diabetes and type 1 diabetes in children, although more data are needed to confirm whether the risk is real.   "What is interesting is that type 1 diabetes is a disease of lack of the hormone insulin while gestational diabetes and type 2 diabetes stem mostly from the body's resistance to the hormone. What may be happening is that genes, environments and behaviors that create insulin resistance may also, in some cases, trigger the immune reactions that lead to type 1 diabetes," adds Dr. Dasgupta. A 2019 meta-analysis by researchers at Soochow University in China found that gestational diabetes was linked to a 66% higher risk of type 1 diabetes in children. This new study, which includes more than twice as many studies, offers a robust synthesis of current evidence and shows the risk is even greater than previously estimated. It is also the first meta-analysis to examine the link between paternal type 2 diabetes and type 1 diabetes in offspring. "Several mechanisms may be at play. Families often share lifestyle and eating habits, which can raise the likelihood that children will be affected. But beyond that, high blood sugar levels may also cause biological changes in parents that could increase their children's risk of developing type 1 diabetes," explains Laura Rendon, co-first author of the study, who completed an MSc in experimental medicine at The Institute and, as someone living with type 1 diabetes herself, finds deep personal meaning in conducting this research. For instance, the authors suggest that high blood sugar during pregnancy may stress the fetus's insulin-producing beta cells, reducing their number at birth or making them more vulnerable to damage later in life. It may also trigger epigenetic changes—modifications to proteins and molecules attached to DNA—that increase the risk. Likewise, high blood sugar in fathers with type 2 diabetes may cause epigenetic changes in their sperm, potentially influencing their child's risk of developing type 1 diabetes. https://medicalxpress.com/news/2025-08-diabetes-children-linked-parents.html XX Can a CGM help you lose weight? The company Signos is banking on it – the just got FDA approval for their system, which uses the over the counter Dexcom Stelo. The claim here is that the system will help track how food choices, activity, stress and sleep can all affect metabolism. Signos also works in partnership with the digital nutrition counseling startup Nourish. It currently offers a quarterly subscription plan, including six CGM sensors, for $139 per month. And they tell you don't take any medical actions based on the app's output without consulting a physician. https://www.fiercebiotech.com/medtech/fda-clears-signos-over-counter-cgm-powered-weight-loss-app XX Good news for T1D1, a free mobile app that helps people calculate insulin doses, track daily data, and share insights with healthcare providers. After being pulled off the market with similar apps a few years ago, it's now back and FDA approved. Drew Mendelow created the app after his diagnosis at age 13. He came on the show last year and I'll link his story up in the show notes. Diabetes Center Berne provided the initial funding to support the T1D1 efforts to redesign the app per FDA standards.  Comerge AG , the registered manufacturer, enlisted a team of software engineers, regulatory experts, and design professionals to ensure T1D1 was FDA-ready. Dexcom graciously conducted the Human Factors study to ensure safety and accuracy.  ​ ​T1D1 is now FDA-cleared as a Class II medical device and is the first over-the-counter insulin calculator cleared for individuals aged 2 and older. T1D1 is expected to be live in the AppStore and Google Play Store by October 2025. https://diabetes-connections.com/the-fda-took-down-this-teens-free-bolus-calculator-he-needs-your-help-to-bring-it-back/ XX Metformin has been the standard treatment for type 2 diabetes for more than six decades, yet scientists still do not fully understand how it works. A team from Baylor College of Medicine, working with international collaborators, has now identified an unexpected factor in its effectiveness: the brain. Their findings reveal a brain pathway involved in metformin's glucose-lowering action, pointing to new strategies for treating diabetes with greater precision. The study was published in Science Advances. The researchers concentrated on a small protein called Rap1, located in a region of the brain known as the ventromedial hypothalamus (VMH). They discovered that metformin's ability to lower blood sugar at clinically relevant doses depends on suppressing Rap1 activity in this brain area.   “This discovery changes how we think about metformin,” Fukuda said. “It's not just working in the liver or the gut, it's also acting in the brain. We found that while the liver and intestines need high concentrations of the drug to respond, the brain reacts to much lower levels.”     https://scitechdaily.com/after-60-years-scientists-uncover-hidden-brain-pathway-behind-diabetes-drug-metformin/   XX Looks like GLP-1 pills are moving ahead. Lilly says it's version helped overweight adults with type 2 lose 10% of their body weights and lower A1C. Just two weeks ago, we were talking about how the same drug in people without diabetes had less than the stellar expected results. Orforglipron is a small-molecule pill that is easier to manufacture and package than wildly popular injectable drugs for obesity, such as Lilly's Zepbound and Novo Nordisk's NOVOb.CO rival treatment Wegovy, which are peptide mimics of the appetite-controlling GLP-1 hormone. In the 72-week study of more than 1,600 overweight or obese adults with type 2 diabetes, those who received the 36-milligram highest dose of orforglipron on average shed 10.5% of their weight, or about 23 pounds (10.43 kg), versus 2.2% for those who received a placebo, achieving the main goal of the trial. Patients on the lowest 6 mg dose of the Lilly drug lost 5.5% of their weight. https://www.usatoday.com/story/news/health/2025/08/26/lilly-glp-1-pill-weight-loss/85830686007/ XX     An intervention that combined a low-calorie Mediterranean diet and exercise led to less diabetes incidence in older adults. Men had a greater diabetes risk reduction with the intervention than women. The study was based in Spain, and the diet may not be as easy to adhere to in the U.S. Among nearly 5,000 adults with metabolic syndrome and overweight or obesity in the PREDIMED-Plus trial, those who followed this intervention had a 31% lower risk for type 2 diabetes over 6 years relative to those who received only ad libitum Mediterranean diet advice (aHR 0.69, 95% CI 0.59-0.82). the Mediterranean diet focuses on high intake of plant-based foods, moderate consumption of fish, poultry, and dairy with optional red wine, and low intake of red meats, sweets, and sugar-sweetened beverages. Common foods featured in the diet include extra-virgin olive oil, fruits, vegetables, legumes, nuts, and whole grains. However, Sharon Herring, MD, MPH, and Gina Tripicchio, PhD, MSEd, both of Temple University in Philadelphia, pointed out that this study was conducted solely in Spain, and sticking to this type of diet may be more challenging in countries like the U.S.   "Participants in the study received extra-virgin olive oil to support adherence and retention; in the United States, prices of extra-virgin olive oil have nearly doubled since 2021 due to a combination of factors including climate change, rising production costs, supply chain disruptions, and now tariffs," they noted in an accompanying editorial. "[T]he large number of dietitian contacts during the study may prove difficult to scale broadly in the United States given challenges with health care access and reimbursement for prevention services."         https://www.medpagetoday.com/primarycare/diabetes/117151 XX A group of Canadian researchers has identified an unexpected way to lower blood sugar and protect the liver: by capturing a little-known fuel produced by gut bacteria before it enters the body and causes harm. The findings, published in Cell Metabolism, could open the door to new therapies to treat metabolic diseases like type 2 diabetes and fatty liver disease. Scientists from McMaster University, Université Laval, and the University of Ottawa discovered that a molecule generated by gut microbes can cross into the bloodstream, where it drives the liver to overproduce glucose and fat. By designing a method to trap this molecule in the gut before it reaches circulation, they achieved striking improvements in blood sugar regulation and fatty liver disease in obese mice. https://scitechdaily.com/scientists-discover-a-surprising-new-way-to-fight-diabetes/ XX Dexcom, which specializes in technology for glucose biosensing, will lay off 350 workers, with nearly 200 of them in San Diego, according to the San Diego Union Tribune. The bulk of the local jobs being lost are focused on Dexcom operations and manufacturing. The Dexcom development follows cutbacks to Verily, a life sciences company that is a subsidiary of Alphabet, Google's corporate parent. Verily's work included a project with Dexcom on wearable glucose sensors. CEO Stephen Gillett, in a memo obtained by the publication, said there will be “workforce reductions across Verily.” A representative for Verily confirmed to Business Insider that “we have made the difficult decision to discontinue manufacturing medical devices and will no longer be supporting them going forward.” https://timesofsandiego.com/business/2025/08/27/report-life-sciences-firm-dexcom-lay-off-200-san-diego-workers/ XX Front office changes at Insulet. Eric Benjamin, former chief product and customer experience officer, will take the role of chief operating officer, effective immediately. Manoj Raghunandanan Mu-NOHJ Rug-a-nun-da-nun to the position of chief growth officer, leading Insulet's new growth organization. The appointments are some of CEO Ashley McEvoy's first changes since she was hired in April. The appointments come after McEvoy outlined four priorities for Insulet on an August earnings call:   enhancing the company's commercial capabilities, building Insulet's brand and direct-to-consumer capabilities, driving growth outside of the U.S. and accelerating the pace of innovation. https://www.medtechdive.com/news/insulet-eric-benjamin-manoj-raghunandanan-appointments/758668/ XX   XX Want to highlight The Children's Diabetes Foundation in Colorado – they held a medal ceremony for patients of the Barbara Davis Center who've lived with Type 1 diabetes for 50 years or more. There were 87 medal recipients in the ceremony including Dana Davis, Executive Director of the Children's Diabetes Foundation and the daughter of the founders of the Barbara Davis Center. Davis shared: "When you got Type1 diabetes in the 70s, they thought you shouldn't have children. They thought you weren't going to live past 30 or 40. It was definitely very different," Davis said.   https://www.cbsnews.com/colorado/news/barbara-davis-center-celebrates-colorado-type-1-diabetes-patients-milestone/

In this special edition episode, recorded live at the ASCO Annual Meeting, hosts Shikha Jain, MD, and Edward Kim, MD, honor Healio's 2025 Disruptive Innovators for their positive disruption in the field of hematology/oncology, and for pushing the status quo to improve clinical practice.  •    Welcome to the fourth annual Healio Disruptive Innovator Awards in hematology/oncology. 1:00 •    VK Gadi, MD PhD, presents the Health Equity Award. 3:56 •    The Health Equity Award winner, Ana Velázquez Mañana, MD, makes a speech. 6:00 •    Morgan Collier presents the Woman Disruptor of the Year Award. 7:38 •    Betty S. Pace, MD, accepts the Woman Disruptor of the Year Award. 9:19 •    The Social Media Influencer Award, presented by Eleonora Teplinsky, MD. 11:53 •    Amani Jambhekar, MD, also known as @ajvictorymd on Instagram and TikTok, accepts the Social Media Influencer Award. 13:13 •    Brenda M. Nevidjon, MSN, RN, FAAN, presents the Advanced Practice Trailblazer Award. 14:40 •    Ashley Leak Bryant, PhD, RN, OCN, FAAN, delivers her acceptance speech for the Advanced Practice Trailblazer Award. 16:19 •    Kamal Jethwani, MD, MPH, presents the Patient Voice Award. 18:44 •    Founder Kimberly Richardson, MA, accepts the Patient Voice Award for the Black Cancer Collaborative. 20:44 •    Healio's chief content officer, Joan-Marie Stiglich, ELS, presents the NextGen Disruptor Award to Nazli Dizman, MD. 22:22 •    The Clinical Innovation Award goes to UNC Lineberger Comprehensive Cancer Center for their at-home symptom reporting, led by Ethan Basch, MD, MSc. 24:18 •    Hope S. Rugo, MD, wins the Lifetime Disruptor Award. 26:48 •    The Industry Breakthrough Award goes to Breyanzi (lisocabtagene maraleucel, or liso-cel) from Bristol Myers Squibb. 30:57 •    On behalf of Bristol Myers Squibb, Amy Corrao, MSN, NP-C, accepts the Industry Breakthrough Award. 32:33 •    Thanks to all of the winners, nominees and sponsors! 35:39 •    Thanks for listening. 36:21 We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Read the full coverage from Healio's Disruptive Innovators here.

This episode of the Global Hemophilia Report explores the long-overdue conversation about women with hemophilia. Experts discuss the challenges women face in getting diagnosed, the persistent gaps in clinical research and care, and the impact of outdated language and systemic bias. The panel highlights the need for better data, more inclusive clinical trials, and a shift in medical culture to ensure women with hemophilia are recognized and prioritized.    Guests: Michelle Sholzberg MDCM, FRCPC, MSc. Dawn Rotellini Len Valentino, MD Robert Sidonio, Jr., MD   Senior Advisor: Donna DiMichele, MD   Hosted by: Patrick James Lynch   Written by: Kay Vermeil   Featured Advertiser: Sanofi   Subscribe to the Global Hemophilia Report   Show Notes:   Presenting Sponsor: Presented by Sanofi Join Shellye as she shares her inspiring journey as a woman living with hemophilia. After years of unanswered questions, her diagnosis highlights the critical role of health literacy in bridging care gaps. Through advocacy, Shellye raises awareness and empowers underserved communities. Watch her story and see how health literacy can break barriers and transform lives. Click here to watch her story: Sanofi – See Hemophilia Through My Eyes: Women & Girls For too long, women and girls who bleed have been dismissed. Left out of the narrative. Ignored by the system. But not anymore. In our new film, “Dismissed,” meet Isabelle—a 15-year-old with hemophilia who's using her voice to uplift the unheard. Alongside her are four powerful stories of women challenging what's "normal" and demanding recognition, care, and justice. This is more than a film. It's a movement.

Dr. Christopher Timmermann is neuroscientist and co-director of the UCL Centre for Consciousness Research in London. He obtained a BSc in Psychology in Santiago, Chile and an MSc in Cognitive Neuroscience at the University of Bologna in Italy. He was also leading one of the first DMT research groups at Imperial College London.His empirical and theoretical work focuses on the neuroscience, psychiatry, psychology, and beliefs of psychedelics, their relationship to consciousness and applications in mental health. The work he has led has been published in high-regarded journals, and has been widely covered by mass media outlets. He also founded and is the director of an educational non-profit in Chile, the ECOH Foundation.He is the expert on 5MeO DMT right, which has been dubbed the “Mount Everest of psychedelics,” and fittingly, Timmermann writes, “its experiences are often referred to as “whiteouts.” But beyond its ability to eliminate the sense of space and time, its most interesting effect lies in the way it dissolves the self. This is key. The question of whether the self is necessary for consciousness to occur has been debated by philosophers for thousands of years — and it remains unsettled. But with 5MeO, something completely different happens: It radically deconstructs all possible worlds, sparing only awareness.IG: christophertimmermannOUR INFO: IG: @the.newhealthclub @thenewhealthinstitute Website: https://www.thenewhealthinstitute.org/ Hosted on Acast. See acast.com/privacy for more information.

In this episode Dominic Bowen and Yaroslav Lissovolik dive into the challenges and opportunities of BRICS! Find out more about the economic Asymmetries and power dynamics, consensus and decision-making, future strategies, BRICS' role in global governance, Russia's position, future cooperation, BRICS plus, international risks and opportunities, and more!Yaroslav Lissovolik worked in the International Monetary Fund, in Washington, where he was Advisor to the Executive Director for the Russian Federation (2001–2004). In 2004 he joined Deutsche Bank as Chief Economist and became Head of Company Research in Russia in 2009, and then a member of the Management Board of Deutsche Bank in Russia in 2011. In 2015–2018 Yaroslav Lissovolik was Chief Economist and subsequently Managing Director of Research and Member of the Management Board at the Eurasian Development Bank (EDB). From 2018 to 2022 he has been Senior Managing Director — Head of Research at Sberbank Investment Research (CIB). In 2023 he founded BRICS+ Analytics to conduct in-depth research on the future trajectories of BRICS+ development.   Yaroslav Lissovolik graduated from Harvard University (magna cum laude) with a BA degree in Economics, and received an MSc in Economics degree from the London School of Economics (LSE). He also received his PhD degree in Economics from the Moscow State Institute for International Relations (MGIMO, red diploma) and a Doctorate in Economics from the Diplomatic Academy. Yaroslav Lissovolik is also a member of Bretton Woods Committee.  He has published several books and numerous papers on Russia's entry into the WTO, BRICS and other economic policy issues.The International Risk Podcast brings you conversations with global experts, frontline practitioners, and senior decision-makers who are shaping how we understand and respond to international risk. From geopolitical volatility and organised crime, to cybersecurity threats and hybrid warfare, each episode explores the forces transforming our world and what smart leaders must do to navigate them. Whether you're a board member, policymaker, or risk professional, The International Risk Podcast delivers actionable insights, sharp analysis, and real-world stories that matter. The International Risk Podcast – Reducing risk by increasing knowledge.Follow us on LinkedIn and Subscribe for all our updates!Tell us what you liked!

Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this episode, "Navigating Transition: Supporting Young Adults With Epilepsy Into Adult Care," Danielle Andrade, MD, MSc, adult neurologist at the University of Toronto and co-chair of the ILAE Transition Task Force, discussed the critical process of moving pediatric patients with epilepsy into adult care. She highlighted findings from the task force's global survey on transition practices, revealing major differences across regions. Andrade also shared important considerations for students with epilepsy entering college, including lifestyle management and the “perfect storm” of seizure triggers like sleep deprivation, alcohol, and medication adherence. She spoke on the vital role of reproductive health discussions, the utility of readiness questionnaires, and the challenges of coordinating multi-specialty care. Finally, Andrade underscored the importance of clear communication between pediatric and adult neurologists, as well as the need for stronger guidelines and education worldwide. Looking for more Epilepsy discussion? Check out the NeurologyLive® Epilepsy clinical focus page. Episode Breakdown: 1:00 – Global survey findings on epilepsy transition of care 2:10 – Key considerations for students with epilepsy entering college 3:50 – Ensuring continuity of care during transition into adulthood 5:45 – Neurology News Minute 7:30 – Common challenges and strategies to overcome them 9:30 – Final thoughts on back-to-school care and global survey insights The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Ianalumab Meets Primary End Points in Phase 3 NEPTUNUS Trials of Sjögren's Disease Praxis' Vormatrigine Shows Significant Ability to Reduce Seizure Incidence in Phase 2 RADIANT Study FDA Denies Approval for Friedreich Ataxia Agent Vatiquinone, Citing More Efficacy Needed Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.

In this episode, editor in chief Joseph E. Safdieh, MD, FAAN, highlights articles about whether small fiber neuropathy is an autoimmune disorder; Merit Cudkowicz, MD, MSc, FAAN, recipient of this year's AAN Lifetime Achievement Award for Clinically Relevant Research; and how neurologist couples pursue work-life balance.

In today's VETgirl online veterinary continuing education podcast, we interview Dr. Nick Jeffery, BVSc, PhD, MSc, DECVS, DECVN, Professor in Neurology and Neurosurgery from Texas A&M on a recent study by Freeman et al entitled “Percutaneous enzymatic chemonucleolysis of intervertebral disks appears safe and effective in treatment of acute-onset paraparesis and paraplegia in small dogs,” published in JAVMA in March 2025. Can the use of intradiscal chondroitinase ABC (often called "CHASE") injections under fluoroscopic-guidance work as a safe, minimally invasive option for small dogs with acute nonambulatory paraparesis or paraplegia, especially when deep pain perception is intact? If you're a general practitioner who sees a lot of down dogs—and especially if you practice in a Dachshund-heavy region—you'll definitely want to tune in.

Multiple system atrophy is a rare, sporadic, adult-onset, progressive, and fatal neurodegenerative disease. Accurate and early diagnosis remains challenging because it presents with a variable combination of symptoms across the autonomic, extrapyramidal, cerebellar, and pyramidal systems. Advances in brain imaging, molecular biomarker research, and efforts to develop disease-modifying agents have shown promise to improve diagnosis and treatment. In this episode, Casey Albin, MD speaks with Tao Xie, MD, PhD, author of the article “Multiple System Atrophy” in the Continuum® August 2025 Movement Disorders issue. Dr. Albin is a Continuum® Audio interviewer, associate editor of media engagement, and an assistant professor of neurology and neurosurgery at Emory University School of Medicine in Atlanta, Georgia. Dr. Xie is director of the Movement Disorder Program, chief of the Neurodegenerative Disease Section in the department of neurology at the University of Chicago Medicine in Chicago, Illinois. Additional Resources Read the article: Multiple System Atrophy Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @caseyalbin Full episode transcript available here Dr. Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Albin: Hello everyone, this is Dr Casey Albin. Today I'm interviewing Dr Tao Xie about his article on diagnosis and management of multiple system atrophy, which appears in the August 2025 Continuum issue on movement disorders. Welcome to the podcast, and please introduce yourself to our audience. Dr Xie: Thank you so much, Dr Albin. My name is Tao Xie, and sometimes people also call me Tao Z. I'm a mood disorder neurologist, professor of neurology at the University of Chicago. I'm also in charge of the mood disorder program here, and I'm the section chief in the neurodegenerative disease in the Department of Neurology at the University of Chicago Medicine. Thank you for having me, Dr Albin and Dr Okun and the American Academy of Neurology. This is a great honor and pleasure to be involved in this education session. Dr Albin: We are delighted to have you, and thank you so much for the thoughtful approach to the diagnosis and management. I really want to encourage our listeners to check out this article. You know, one of the things that you emphasize is multiple system atrophy is a fairly rare condition. And I suspect that clinicians and trainees who even have a fair amount of exposure to movement disorders may not have encountered that many cases. And so, I was hoping that you could just start us off and walk us through what defines multiple system atrophy, and then maybe a little bit about how it's different from some of the more commonly encountered movement disorders. Dr Xie: This is a really good question, Dr Albin. Indeed, MSA---multisystem atrophy----is a rare disease. It is sporadic, adult-onset, progressive, fatal neurodegenerative disease. By the name MSA, multisystem atrophy. Clinically, it will present with multiple symptoms and signs involving multiple systems, including symptoms of autonomic dysfunction and symptoms of parkinsonism, which is polyresponsive to the levodopa treatment; and the symptom of cerebellar ataxia, and symptom of spasticity and other motor and nonmotor symptoms. And you may be wondering, what is the cause- underlying cause of these symptoms? Anatomically, we can find the area in the basal ganglia striatonigral system, particularly in the putamen and also in the cerebellar pontine inferior, all of the nuclear area and the specific area involved in the autonomic system in the brain stem and spinal cord: all become smaller. We call it atrophy. Because of the atrophy in this area, they are responsible for the symptom of parkinsonism if it is involved in the putamen and the cerebral ataxia, if it's involved in the pons and cerebral peduncle and the cerebellum. And all other area, if it's involved in the autonomic system can cause autonomic symptoms as well. So that's why we call it multisystem atrophy. And then what's the underlying cellular and subcellular pathological, a hallmark that is in fact caused by misfolded alpha-synuclein aggregate in the oligodontia site known as GCI---glial cytoplasmic increasing bodies---in the cells, and sometimes it can also be found in the neuronal cell as well in those areas, as mentioned, which causes the symptom. But clinically, the patient may not present all the symptoms at the same time. So, based on the predominant clinical symptom, if it's mainly levodopa, polyresponsive parkinsonism, then we call it MSAP. If it's mainly cerebellar ataxia, then we call it MSAC. But whether we call it MSP or MSC, they all got to have autonomic dysfunction. And also as the disease progresses, they can also present both phenotypes together. We call that mixed cerebellar ataxia and parkinsonism in the advanced stage of the disease. So, it is really a complicated disease. The complexity and the similarity to other mood disorders, including parkinsonism and the cerebellar ataxia, make it really difficult sometimes, particularly at the early stages of disease, to differentiate one from the other. So, that was challenging not only for other professionals, general neurologists and even for some movement disorder specialists, that could be difficult particularly if you aim to make an accurate and early diagnosis. Dr Albin: Absolutely. That is such a wealth of knowledge here. And I'm going to distill it just a little bit just to make sure that I understand this right. There is alpha-synuclein depositions, and it's really more widespread than one would see maybe in just Parkinson's disease. And with this, you are having patients present with maybe one of two subtypes of their clinical manifestations, either with a Parkinson's-predominant movement disorder pattern or a cerebellar ataxia type movement disorder pattern. Or maybe even mixed, which really, you know, we have to make things quite complicated, but they are all unified and having this shared importance of autonomic features to the diagnosis. Have I got that all sort of correct? Dr Xie: Correct. You really summarize well. Dr Albin: Fantastic. I mean, this is quite a complicated disease. I would pose to you sort of a case, and I imagine this is quite common to what you see in your clinic. And let's say, you know, a seventy-year-old woman comes to your clinic because she has had rigidity and poor balance. And she's had several falls already, almost always from ground level. And her family tells you she's quite woozy whenever she gets up from the chair and she tends to kind of fall over. But they noticed that she's been stiff,and they've actually brought her to their primary care doctor and he thought that she had Parkinson's disease. So, she started levodopa, but they're coming to you because they think that she probably needs a higher dose. It's just not working out very well for her. So how would you sort of take that history and sort of comb through some of the features that might make you more concerned that the patient actually has undiagnosed multiple systems atrophy? Dr Xie: This is a great case, because we oftentimes can encounter similar cases like this in the clinic. First of all, based on the history you described, it sounds like an atypical parkinsonism based on the slowness, rigidity, stiffness; and particularly the early onset of falls, which is very unusual for typical Parkinson disease. It occurs too early. If its loss of balance, postural instability, and fall occurred within three years of disease onset---usually the motor symptom onset---then it raises a red flag to suspect this must be some atypical Parkinson disorders, including multiple system atrophy. Particularly, pou also mentioned that the patient is poorly responsive to their levodopa therapy, which is very unusual because for Parkinson disease, idiopathic Parkinson disease, we typically expect patients would have a great response to the levodopa, particularly in the first 5 to 7 years. So to put it all together, this could be atypical parkinsonism, and I could not rule out the possibility of MSA. Then I need to check more about other symptoms including autonomic dysfunction, such as orthostatic hypertension, which is a blood pressure drop when the patient stands up from a lying-down position, or other autonomic dysfunctions such as urinary incontinence or severe urinary retention. So, in the meantime, I also have to put the other atypical Parkinson disorder on the differential diagnosis, such as PSP---progressive supranuclear palsy---and the DLBD---dementia with Lewy body disease.---Bear this in mind. So, I want to get more history and more thorough bedside assessment to rule in or rule out my diagnosis and differential diagnosis. Dr Albin: That's super helpful. So, looking for early falls, the prominence of autonomic dysfunction, and then that poor levodopa responsiveness while continuing to sort of keep a very broad differential diagnosis? Dr Xie: Correct. Dr Albin: One of the things that I just have to ask, because I so taken by this, is that you say in the article that some of these patients actually have preservation of smell. In medical school, we always learn that our Parkinson's disease patients kind of had that early loss of smell. Do you find that to be clinically relevant? Is that- does that anecdotally help? Dr Xie: This is a very interesting point because we know that the loss of smelling function is a risk effect, a prodromal effect, for the future development of Parkinson disease. But it is not the case for MSA. Strange enough, based on the literature and the studies, it is not common for the patient with MSA to present with anosmia. Some of the patients may have mild to moderate hyposmia, but not to the degree of anosmia. So, this is why even in the more recent diagnosis criteria, the MDS criteria published 2022, it even put the presence of anosmia in the exclusion criteria. So, highlight the importance of the smell function, which is well-preserved for the majority in MSA, into that category. So, this is a really interesting point and very important for us, particularly clinicians, to know the difference in the hyposmia, anosmia between the- we call it the PD, and the dementia Lewy bodies versus MSA. Dr Albin: Fascinating. And just such a cool little tidbit to take with us. So, the family, you know, you're talking to them and they say, oh yes, she has had several fainting episodes and we keep taking her to the primary care doctor because she's had urinary incontinence, and they thought maybe she had urinary tract infections. We've been dealing with that. And you're sort of thinking, hm, this is all kind of coming together, but I imagine it is still quite difficult to make this diagnosis based on history and physical alone. Walk our listeners through sort of how you're using MRI and DAT scan and maybe even some other biomarkers to help sort of solidify that diagnosis. Dr Xie: Yeah, that's a wonderful question. Yeah. First of all, UTI is very common for patients with MSA because of urinary retention, which puts them into a high risk of developing frequent UTI. That, for some patients, could be the very initial presentation of symptoms. In this case, if we check, we say UTI is not present or UTI is present but we treat it, then we check the blood pressure and we do find also hypertension---according to new diagnosis criteria, starting drop is 20mm mercury, but that's- the blood pressure drop is ten within three minutes. And also, in the meantime the patients present persistent urinary incontinence even after UTI was treated. And then the suspicion for MS is really high right at this point. But if you want increased certainty and a comfortable level on your diagnosis, then we also need to look at the brain MRI mark. This is a required according to the most recent MDS diagnosis criteria. The presence of the MRI marker typical for MSA is needed for the diagnosis of clinically established MSA, which holds the highest specificity in the clinical diagnosis. So then, we have- we're back to your question. We do need to look at the brain MRI to see whether evidence suggestive of atrophy around the putamen area, around the cerebellar pontine inferior olive area, is present or not. Dr Albin: Absolutely. That's super helpful. And I think clinicians will really take that to sort of helping to build a case and maybe recognizing some of this atypical Parkinson's disease as a different disease entity. Are there any other biomarkers in the pipeline that you're excited about that may give us even more clarity on this diagnosis? Dr Xie: Oh, yeah. This is a very exciting area. In terms of biomarker for the brain imaging, particularly brain MRI, in fact, today there's a landmark paper just published in the Java Neurology using AI, artificial intelligence or machine learning aid, diagnoses a patient with parkinsonism including Parkinson's disease, MSA, and PSP, with very high diagnostic accuracy ranging from 96% to 98%. And some of the cases even were standard for autopsy, with pathological verification at a very high accurate rate of 93.9%. This is quite amazing and can really open new diagnosis tools for us to diagnose this difficult disease; not only in an area with a bunch of mood disorder experts, but also in the rural area, in the area really in need of mood disorder experts. They can provide tremendous help to provide accurate, early diagnosis. Dr Albin: That's fantastic and I love that, increasing the access to this accurate diagnosis. What can't artificial intelligence do for us? That's just incredible. Dr Xie: And also, you know, this is just one example of how the brain biomarker can help us. Theres other---a fluid biomarker, molecular diagnostic tools, is also available. Just to give you an example, one thing we know over the past couple years is skin biopsy. Through the immunofluorescent reaction, we can detect whether the hallmark of abnormally folded, misfolded, and the phosphorate, the alpha-synuclein aggregate can be found just by this little pinch of skin biopsy. Even more advanced, there's another diagnosis tool we call the SAA, we call the seizure amplification assay, that can even help us to differentiate MSA from other alpha-synucleinopathy, including Parkinson disease and dementia with Lewy bodies. If we get a little sample from CSF, spinal cerebral fluids, even though this is probably still at the early stage, a lot of developments still ongoing, but this, this really shows you how exciting this area is now. We're really in a fast forward-moving path now. Dr Albin: It's really incredible. So, lots coming down the track in, sort of, MRI, but also with CSF diagnosis and skin biopsies. Really hoping that we can hone in some of those tools as they become more and more validated to make this diagnosis. Is that right? Dr Xie: Correct. Dr Albin: Amazing. We can talk all day about how you manage these in the clinic, and I really am going to direct our listeners to go and read your fantastic article, because you do such an elegant job talking about how this takes place in a multidisciplinary setting, if at all possible. But as a neurointensivist, I was telling you, we have so much trouble in the hospital. We have A-lines, and we have the ability to get rapid KUBs to look at Ilias, and we can have many people as lots of diagnosis, and we still have a lot of trouble treating autonomiclike symptoms. Really, really difficult. And so, I just wanted to kind of pick your brain, and I'll start with just the one of orthostatic hypotension. What are some of the tips that you have for, you know, clinicians that are dealing with this? Because I imagine that this is quite difficult to do without patients. Dr Xie: Exactly. This is indeed a very difficult symptom to deal with, particularly at an outpatient setting. But nowadays with the availability of more medication---to give an example, to treat patients with orthostatic hypertension, we have not only midodrine for the cortisol, we also have droxidopa and several others as well. And so, we have more tools at hand to treat the patient with orthostatic hypertension. But I think the key thing here, particularly for us to the patient at the outpatient setting: we need to educate the patient's family well about the natural history of the disease course. And we also need to tell them what's the indication and the potential side effect profile of any medication we prescribe to them so that they can understand what to expect and what to watch for. And in the meantime, we also need to keep really effective and timely communication channels, make sure that the treating physician and our team can be reached at any time when the patient and family need us so that we can be closely monitoring, their response, and also monitoring potential side effects as well to keep up the quality of care in that way. Dr Albin: Yeah, I imagine that that open communication plays a huge role in just making sure that patients are adapting to their symptoms, understanding that they can reach out if they have refractory symptoms, and that- I imagine this takes a lot of fine tuning over time. Dr Xie: Correct. Dr Albin: Well, this has just been such a delight to get to talk to you. I really feel like we could dive even deeper, but I know for the sake of time we have to kind of close out. Are there any final points that you wanted to share with our listeners before we end the interview? Dr Xie: I think for the patients, I want them to know that nowadays with advances in science and technology, particularly given a sample of rapid development in the diagnostic tools and the multidisciplinary and multisystemic approach to treatment, nowadays we can make an early and accurate diagnosis of the MSA, and also, we can provide better treatment. Even though so far it is still symptomatically, mainly, but in the near future we hope we can also discover disease-modifying treatment which can slow down, even pause or prevent the disease from happening. And for the treating physician and care team professionals, I just want them to know that you can make a difference and greatly help the patient and the family through your dedicated care and also through your active learning and innovative research. You can make a difference. Dr Albin: That's amazing and lots of hope for these patients. Right now, you can provide really great care to take care of them, make an early and accurate diagnosis; but on the horizon, there are really several things that are going to move the field forward, which is just so exciting. Again today, I've been really greatly honored and privileged to be able to talk to Dr Tao Xie about his article on diagnosis and management of multiple system atrophy, which appears in the August 2025 Continuum issue on movement disorders. Be sure to check out Continuum Audio episodes for this and other issues. And thank you again to our listeners for joining us today. Dr Xie: Thank you so much for having me. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

In this episode of Future Finance, host Glenn Hopper and co-host Paul Barnhurst welcome Nicolas Kopp, a visionary leader in the AI-native ERP space. Nicolas shares how AI is transforming finance operations by offering real-time visibility, automation, and a path to zero-day close. He explains how AI integration redefines financial workflows, from data ingestion and processing to output, offering a more streamlined approach compared to traditional systems.Nicolas Kopp is the founder and CEO of Rillet, the AI-native ERP designed to automate accounting and close books faster. Backed by Sequoia, Rillet empowers accountants by integrating AI seamlessly into financial workflows. Previously, Nicolas served as the US CEO of N26, a fintech bank valued at $9 billion, where he played a key role in leading its expansion into the US market. Prior to N26, he spent five years in investment banking at Morgan Stanley. Nicolas holds a BA from the University of St. Gallen in Switzerland and an MSc in Accounting from the London School of Economics.Expect to Learn:The difference between AI-native ERP systems and legacy systemsHow AI is transforming data ingestion and transaction processing in financeThe role of AI agents in automating finance workflows, from cash transfers to accrualsWhy legacy systems struggle to integrate AI and how ReLit does it differentlyThe typical implementation process for AI-native ERPs and how it compares to traditional ERP rolloutsNicolas Kopp provided an insightful look at the future of finance and the potential of AI-native ERP systems. His work with ReLit showcases how AI can transform finance operations, offering real-time visibility and automating complex workflows. From narrowing the scope of AI agents to building smarter systems, Nicolas' insights are invaluable for finance professionals looking to leverage AI for operational success. Follow Nicolas:LinkedIn - https://www.linkedin.com/in/nicolas-kopp/Website - https://www.rillet.com/Join hosts Glenn and Paul as they unravel the complexities of AI in finance:Follow Glenn:LinkedIn: https://www.linkedin.com/in/gbhopperiiiFollow Paul: LinkedIn - https://www.linkedin.com/in/thefpandaguyFollow QFlow.AI:Website - https://bit.ly/4i1EkjgFuture Finance is sponsored by QFlow.ai, the strategic finance platform solving the toughest part of planning and analysis: B2B revenue. Align sales, marketing, and finance, speed up decision-making, and lock in accountability with QFlow.ai. Stay tuned for a deeper understanding of how AI is shaping the future of finance and what it means for businesses and individuals alike.In Today's Episode:[01:10] - What Makes an AI-native ERP?[03:22] - Integrating AI into Legacy Systems[04:51] - Exploring AI Agents in Workflows[07:24] - How Close Are We to Autonomous AI Agents?[11:31] - The Challenge of Quick ERP Implementations[15:45] - Celebrating Success and Sequoia Backing

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comCurranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours This week on the podcast Mikki speaks to Dr Eric Helms on his last year leading into his return to stage for natural bodybuilding. As always, a great conversation with plenty of take homes for everyone interesting in living their best lives.Eric is a coach, athlete, author, and educator. A trainer since the early 2000's, he's worked in the US Air force, commercial gyms, private training studios, medical fitness and strength and conditioning facilities. As a part of 3DMJ he coaches drug free strength and physique competitors at all levels. Eric has competed since the mid 2000's in natural bodybuilding, unequipped powerlifting and dabbled in Olympic lifting. He earned pro status as a natural bodybuilder with the PNBA in 2011 and competes with the IPF at international level events as an unequipped powerlifter.Eric has published multiple peer reviewed articles in exercise science and nutrition journals and writes for commercial fitness publications. He's taught undergraduate and graduate level nutrition and exercise science and speaks internationally at academic and commercial conferences for fitness, nutrition and strength and conditioning. He has a BSc in fitness and wellness, an MSc in exercise science, a second masters in sports nutrition, a PhD in strength and conditioning, and is a research fellow for AUT at the Sports Performance Research Institute New Zealand. He is also co-founder for MASS monthly strength and conditioning review.Links:Eric Helms: https://3dmusclejourney.com/about/eric-helms/Iron Culture podcast: https://ironculture.libsyn.com/MASS monthly research review: https://www.strongerbyscience.com/mass/Eric on IG https://www.instagram.com/helms3dmj/?hl=enEric on Mikkipedia https://podcast.mikkiwilliden.com/8Eric and Cliff on Mikkipedia https://podcast.mikkiwilliden.com/76 Eric round 3 https://podcast.mikkiwilliden.com/244 Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

Ep 333: Transforming airway health & smiles with MARPE featuring Dr. Svitlana Koval, DMD, MSc, BDSThis week on The Untethered Podcast™, Hallie welcomes back Dr. Svitlana Koval, Florida's leading provider of Miniscrew-Assisted Rapid Palatal Expansion (MARPE). Together, they explore the powerful connection between dental expansion, airway health, and facial balance covering MARPE and clear aligner mechanics, Hallie's personal experience with her children's treatment, timelines, post-care, and the transformative outcomes of a holistic approach.If this episode resonates with you, snap a screenshot of you listening and share it on your Instagram Stories! Tag Hallie @halliebulkin and @drsvitlanakoval to spread the word.In this episode, you'll learn:✔️ Clear Aligner (e.g., Invisalign) Journey and Airway Health✔️ Personal Experience with MARPE and Facial Asymmetry✔️ Understanding MARPE: Procedures and Techniques✔️ Comparing Traditional Expanders and MARPE✔️ Timeline and Procedures for Adult Expansion✔️ Understanding Bone Remodeling and Expansion Techniques✔️ Aesthetic Considerations in Orthodontic Treatment✔️ Timeline for Appliance Removal and Bone Fusion✔️ Impact of Expansion on Facial Structure✔️ Addressing Concerns with Mini Screws and TADs✔️ In-Office Procedure Insights and Patient Care✔️ Managing Asymmetries in Facial StructureRELATED EPISODES YOU MIGHT LOVEEp 263: Breathing Easy – Link Between Orthodontics, Speech & Health with Dr. Svitlana Koval & Tiffany ZilbermanEp 331: Inside My MARPE Journey with yours truly, Hallie BulkinABOUT TODAY'S GUESTI am so excited for you to meet Dr. Svitlana Koval! You can hang out with her over on Instagram and check out her practice at drssk.com.✨ FREE TRAINING ALERT – HAPPENING SEPTEMBER 8–10!If you're an SLP, OT, or student… you need to join me for the FREE 3-Day Pediatric Feeding Screening Training. Over 34,000 of your colleagues have done it — now it's your turn!Here's what you'll get when you sign up:4 hours on a certificate of completion (perfect for your renewal hours)My complete pediatric feeding screening packet — development chart, 50-symptom checklist, findings chart & referral formA chance to win one of FOUR full scholarships to the 12-week Feed The Peds® courseGrab your spot here → www.feedthepeds.com/trainingOTHER WAYS TO CONNECT & LEARN

In this Unshod yarn, Veronica Stanwell of RootedHealing and Daniel explore the themes of community, intentional/slow living, and the importance of stories and ceremonies in our lives. We dialogue about the challenges of modernity, the impact of technology in our little and mammal lives, and the need to reclaim our roots.Veronica shares her experiences living in community in the Southwest of the British Isle, while she also emphasizes the significance of slowing down and participating in embodied practices, from story to ceremony. The conversation centers on the interplay between storytelling and ceremony, and the potential for these embodied memberings to foster healing and transformation in such a modern, fast-paced world. Toward the end, we also get to explore the themes of interconnectivity and language, and the importance of reciprocal relationships with nature using our syllabaries. Touching on animism and ancient languages as a deepening to our connection to the land and our ancestors, while also reflecting on the limitations of modern language.About Veronica: As a multidisciplinary healing + creative arts practitioner, Veronica weaves her love for embodied ecology, land lore, ceremony and song into intimate explorations for connection, healing and growth.  MSc studentship in Consciousness + Transpersonal Psychology with the Alef Trust, alongside work with Rooted Healing (as founder + director), are driven by her fascination with the fabric of life and our belonging within it.  Veronica's background in professional theatre continues to guide her work, carrying reverence for the power of story, music, expression, catharsis and playfulness. Her longing for a collective intimate relationship with life is apparent and contagious. She serves to remind you that we belong and that the mystery of life is worth falling in love with, again and again.Learn more about RootedHealing HERE.Learn more about Daniel's work HERE.

This week Trevor, Tom, and Jenn navigate through choppy waters of cruise news! We're discussing Carnival's big moves with the Mardi Gras switching to shorter Bahamas runs from Port Canaveral in 2027, plus exciting details about the new Carnival Jubilee's music-inspired zones. Find out why Diana Ross backed out of being Star of the Seas' godmother with just days to spare, and how Tropical Storm Aaron might affect current sailings.We also cover MSC's massive expansion into Texas and the Caribbean with 7 ships, the concerning waterslide incident on Icon of the Seas that left a passenger injured, and Royal Caribbean's controversial new drink package policy that affects everyone - even pregnant passengers! Plus, listener messages from Brandon and Tim, including news about Disney Wonder leaving Australia.Join us for technical difficulties, kitten attacks, and Jenn's legendary lag as we sail through this week's cruise updates!Speakpipe Link because if I dont post this then Brando shames me :( https://www.speakpipe.com/CarnivalCruisingPodcastaways

Under the new presidential administration, U.S. public health policy is shifting — particularly in areas like vaccinations, environmental health, and federal oversight. Mark Nathaniel Mead, MSc, a trained epidemiologist and public health research scientist, joins the podcast to explore the evolving landscape of the Department of Health and Human Services (HHS) and what it means for Americans. In this episode, you'll learn: ·       Key takeaways from the recent Senate hearing on science and federal health agencies. ·       How COVID-19 narratives and vaccine information have been suppressed. ·       Potential benefits of revising vaccine schedules for children. ·       Why virus variants may “outsmart” current vaccination strategies. Mark has contributed to publications like Natural Health, Utne Reader, and Integrative Cancer Therapies, and continues to research and publish on vaccine efficacy and safety. Follow Mark online and stay updated on his work via LinkedIn. Keep up with M. Nathaniel Mead socials here: X : https://x.com/SelfHealingOptn  YouTube: https://www.youtube.com/@marknathanielmead595  Episode also available on Apple Podcasts: https://apple.co/38oMlMr

In this episode, we're diving deep into the latest breakthroughs in integrative mental health and wellness with special guest Kirkland Newman, founder of the Mind Health 360. Kirkland is an Anglo-American journalist, philanthropist, and Founder of MindHealth360, a global platform dedicated to integrative mental health and functional medicine psychiatry.   Get full transcript, audio, video & downloads of this episode here: https://www.jillcarnahan.com/kirkland...    SIGN UP NOW FOR IMMH! Link: https://www.immh.org/immh-2025/?ref=1265 Discount code for $50 off registration: CARNAHAN50   Key Topics You'll Discover: ① The surprising link between mitochondria and mental health – and why morning light and movement are your brain's best friends. ② How childhood trauma impacts your body's immune response and can drive chronic illnesses like mold sensitivity and Lyme disease. ③ The real talk on functional medicine: what's working, what's not, and the simple daily habits that make a powerful difference. ④ Insights from thought leaders like Dr. Gabor Maté, Dr. Emran Meyer, and Dr. Dale Bredesen.  

Synopsis: Some of the most game-changing ideas in healthcare come from unexpected intersections—where engineering meets biology, and where data meets patient urgency. This episode of Biotech 2050 dives into that exact convergence with a look at how one visionary leader helped pioneer blood-based cancer diagnostics. Co-CEO & Co-Founder of Guardant Health, AmirAli Talasaz, shares the story behind building one of biotech's most impactful companies. From a graduate student navigating genomics for the first time to raising over $3 billion and leading a public company, he reflects on lessons learned, obstacles faced, and what it takes to create a patient-first culture at scale. The conversation explores the technology behind liquid biopsies and companion diagnostics, the challenges of insurance reimbursement, and how Guardant's innovations are helping detect recurrence and screen for early-stage cancers—all through a simple blood test. Hosted by Biotech 2050 Co-Founder Rahul Chaturvedi, this episode is packed with insights on biotech leadership, pharma partnerships, and building a company that scales with both urgency and heart. Biography: AmirAli Talasaz is the co-CEO of the leading precision oncology company, Guardant Health, which he co-founded in 2012 with Helmy Eltoukhy. Prior to co-founding Guardant Health, he was senior director of Diagnostics Research at Illumina and led the efforts for emerging clinical applications of next-generation genomic analysis. Before Illumina, he founded Auriphex Biosciences, which focused on purification and genetic analysis of circulating tumor cells for cancer management. Talasaz received his PhD in electrical engineering and MSc in management science from Stanford University.

The promise of advanced cell therapies is undeniable, but as demand skyrockets, the challenges of taking a living drug from bench to bedside have never been greater. Each batch brings variability, each jurisdiction adds regulatory hurdles, and every strategic decision can determine whether a lifesaving therapy reaches patients or fizzles out behind clinical barriers.Lindsay Davies is a leading figure in the cell and gene therapy field, serving as Vice President-Elect for Europe at the International Society of Cell and Gene Therapy (ISCT). She is Chief Scientific Officer at NextCell Pharma, co-founder of QVance, and founder of the consultancy CellTherEx. With over 20 years of experience across academia and industry, she brings deep expertise in MSC manufacturing, process development, and commercialization of advanced therapies. Here are three reasons this episode is a must-listen:Manufacturing at Scale, Without Compromise: Lindsay shares why NextCell Pharma has stuck with large-scale 2D manufacturing for MSCs, leveraging cell morphology and a patented donor selection algorithm to reduce batch-to-batch variability while maximizing reproducibility and safety, even when treating hundreds from a single batch.Smart Scaling: Up, Out, or Both? The debate isn't just academic. Lindsay explores when it makes sense to scale up processes versus scaling out to multiple manufacturing sites. She highlights how harmonizing global regulatory expectations and moving to closed 2D systems can lower costs, de-risk production, and bring life-changing therapies to more patients worldwide.Network or Nowhere: Lindsay calls out the myth of the lone innovator, championing the crucial role of strategic networking, partnership models, including “sweat equity”, and early regulatory engagement as keys to avoiding the common commercialization pitfalls that stall so many promising ATMPs.Wondering how to navigate the twin challenges of process control and commercial viability in ATMP development? This episode offers a rare, candid roadmap from the front lines.Connect with Lindsay Davis:LinkedIn: www.linkedin.com/in/lindsay-c-daviesWebsite: www.nextcellpharma.comIf you're interested in breakthroughs in cell therapy, here's what some of our previous guests have shared from the front lines of innovation:Episodes 105-106: From Proteins to Cell Therapy: Why ATMPs Aren't Just Complex Biologics with Oliver KraemerEpisodes 109-110: Spinning Like Earth: Designing Low-Shear Bioreactors for Better Cell Culture with Olivier DetournayEpisodes 125-126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon ShareiNext step:Book a free consultation to help you get started on any questions you may have about bioprocess development: https://bruehlmann-consulting.com/call

Welcome to the thirty-fifth episode of the Zoology Ramblings Podcast! In this episode, Emma and Robi start with some news, including good news for spoonbills in Norfolk, and bat-friendly lighting in the Netherlands. Robi and Emma then review Attenborough's new Oceans film, sharing highlights as well as differing opinions about the effectiveness of top-down vs bottom-up influence. They then dive into their species of the week, where Emma talks about the Aesculapian snakes in the UK and Robi talks about the amazingly camouflaged proboscis bat. For their local conservation stories, Emma discusses the ladybird swarms that have been spotted all across the UK due to warmer weather. Robi takes us on an interesting thought experiment about the history of dholes in Europe and their relationship to big bats. They end this episode with their global conservation stories, where Emma talks about glow in the dark marsupials and Robi shares exciting news about the rediscovered little kiwi. Robi Watkinson is a Conservation Biologist and wildlife filmmaker specialising in the spatial and movement ecology of large carnivores, camera trapping survey methods, rewilding, metapopulation dynamics and conservation planning. He has an MSc in Conservation Biology from the FitzPatrick Institute of African Ornithology, and the Institute of Communities and Wildlife in Africa, University of Cape Town. He is based between Cape Town and London, and has strong interests in equitable and inclusive conservation, palaeontology and wildlife taxonomy and evolution!Emma Hodson is a Zoologist and wildlife content creator, currently working in the community and engagement team at Avon Wildlife Trust. Emma's role as a Wildlife Champions Project Officer involves supporting and upskilling people to take action for nature in their local communities. Emma has experience in remote wildlife fieldwork, and has been part of Arctic fox, macaw and cetacean research teams in Iceland, Peru and Wales respectively. She has also been involved in animal care and rehabilitation work in Costa Rica and South Africa. Emma is particularly passionate about the interface between community engagement and wildlife monitoring, and enjoys running workshops and giving talks on topics including camera trapping, beaver ecology and rewilding. You can watch "Rewilding A Nation" for free on WaterBear by following this link: https://www.waterbear.com/watch/rewilding-a-nation . You can follow more of our weird and wonderful wildlife adventures on instagram: @zoologyramblingspodcast & @robi_watkinson_wildlife & @emma_hodson_wildlife

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Kyle B. Enfield, MD, FCCM, speaks with Garrett McDougall, MS, MSc, and Ben Forestell, MD, of McMaster University about their recent study, “Direct Laryngoscopy Versus Video Laryngoscopy for Intubation in Critically Ill Patients: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Trials,” published in the November 2024 issue of Critical Care Medicine. The study included 20 randomized controlled trials encompassing 4569 patients to investigate whether video laryngoscopy (VL) offers advantages over direct laryngoscopy (DL) for intubation in critically ill patients.  A key finding of the study was that VL probably improves first-pass success rates and reduces the risk of esophageal intubation and dental injury. These benefits extend across the spectrum of operator experience, especially among novice operators but also among seasoned operators.   Drs. McDougall and Forestell discuss findings that surprised them, such as seeing equal benefit for standard VL and hyperangulated VL devices. Additionally, no clear benefits were found for patients who were intubated emergently with VL as compared to those who underwent elective intubation. The discussion covers what could be next for resuscitation and airway research in critically ill patients. There may be more to learn about scenarios involving difficult airways, soiled airways, and emergent versus elective intubation. More research on device characteristics could also provide important insights. To wrap up, the guests underscore the importance of maintaining both VL and DL proficiency since DL can be a more appropriate choice for some patients. Resources referenced in this episode: Direct Laryngoscopy Versus Video Laryngoscopy for Intubation in Critically Ill Patients: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Randomized Trials (McDougall GG, et al. Crit Care Med. 2024;52:1674-1685).

Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring long-term IV access. Author Thomas L. Holland, MD, MSc, from Duke University School of Medicine discusses key points of the DOTS randomized clinical trial and more with JAMA Deputy Editor Preeti Malani, MD, MSJ.Related Content: Dalbavancin for Treatment of Staphylococcus aureus BacteremiaManagement of Staphylococcus aureus Bacteremia

Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring long-term IV access. Author Thomas L. Holland, MD, MSc, from Duke University School of Medicine discusses key points of the DOTS randomized clinical trial and more with JAMA Deputy Editor Preeti Malani, MD, MSJ. Related Content: Dalbavancin for Treatment of Staphylococcus aureus Bacteremia Management of Staphylococcus aureus Bacteremia

In this episode of Future Finance, hosts Glenn Hopper and Paul Barnhurst sit down with Nicolas Kopp, the founder and CEO of Rillet, to discuss how AI is transforming finance operations. The episode dives deep into the practical applications of AI-native ERPs, with Nicolas explaining how his platform redefines general ledger management. The discussion explores the future of finance workflows, from the zero-day close to AI-driven automation in accounting tasks. It's a compelling conversation about integrating advanced technology into finance without needing deep technical expertise.Nicolas Kopp is the founder and CEO of Rillet, the AI-native ERP designed to automate accounting and close books faster. Backed by Sequoia, Rillet empowers accountants by integrating AI seamlessly into financial workflows. Previously, Nicolas served as the US CEO of N26, a fintech bank valued at $9 billion, where he played a key role in leading its expansion into the US market. Prior to N26, he spent five years in investment banking at Morgan Stanley. Nicolas holds a BA from the University of St. Gallen in Switzerland and an MSc in Accounting from the London School of Economics.In this episode, you will discover:How AI-native ERP systems like Rillet are revolutionizing general ledger operations.The process of automating complex accounting workflows with AI agents.Why finance leaders need to embrace AI and the practical steps to do so.The challenges and benefits of shifting from legacy systems to AI-driven platforms.How CFOs can leverage AI today, even without a dedicated tech team.Nicolas shared his journey from investment banking to leading Rillet, offering an inspiring look at how AI-native ERPs are transforming finance operations. His insights on automating workflows, achieving zero-day closes, and embracing AI-driven innovation provide essential guidance for finance leaders looking to stay ahead in the evolving landscape. This episode is a must-listen for professionals eager to drive change, innovate, and lead with purpose in the AI-powered future of finance.Follow Nicolas:LinkedIn - https://www.linkedin.com/in/nicolas-kopp/Website - https://www.rillet.com/Join hosts Glenn and Paul as they unravel the complexities of AI in finance:Follow Glenn:LinkedIn: https://www.linkedin.com/in/gbhopperiiiFollow Paul:LinkedIn - https://www.linkedin.com/in/thefpandaguyFollow QFlow.AI:Website - https://bit.ly/4i1EkjgFuture Finance is sponsored by QFlow.ai, the strategic finance platform solving the toughest part of planning and analysis: B2B revenue. Align sales, marketing, and finance, speed up decision-making, and lock in accountability with QFlow.ai. Stay tuned for a deeper understanding of how AI is shaping the future of finance and what it means for businesses and individuals alike.In Today's Episode:[02:57] - What is an AI Native ERP?[06:41] - AI Agents and Workflow[09:15] - The Future of AI Agents with Autonomy[11:47] - The Story Behind the General Ledger[16:15] - The ERP Implementation Process[23:43] - CFO...

Gary is joined by Adi Viveash, who recently joined Middlesbrough first team coaching staff and also spent eight years at Chelsea as assistant Academy and assistant reserve team coach before being named Under-18 manager in July 2011. He was promoted to development squad manager in 2014, which saw him lead Chelsea's Under-21s. During his time at Chelsea, among the players Adi had a key hand in developing were Marc Guehi, Conor Gallagher, Callum Hudson-Odoi, Mason Mount and Reece James. His departure from the Blues was confirmed in May 2017 but two months later he was back in work having been named assistant manager at Coventry City. In this interview, Adi gives a unique perspective on life at Chelsea, how the game has changed in the last 10 years, the variables that coaches must take into consideration, how coaches manage elite level players who are on the verge of the first team, plus the difference between first team coaching and development. An extra special thanks to SportsLab360 for teaming up with us on this episode. Since 2016 they've been helping thousands of coaches empower their players to improve their Soccer IQ and decision-making on the pitch. It's one of the easiest and most affordable ways to get more out of your team. We have a special offer for MSC listeners at the halfway point of the interview! Click below to check them out: https://sportslab360.com/

Strata, Ireland's leading provider of construction time management and digital construction services, recently released the 2025 Strata Report: Digital Transformation in Construction. Ronan recently caught up with Enda Grimes, the Director and Founder of Strata to find out more about the 2025 Strata Report and digital transformation in the construction sector.Enda talks about his background, what Strata does, the 2025 Strata Report, AI, and more.More about Enda Grimes:Enda Grimes is the Director and Founder of Strata, Ireland's leading provider of construction time management and digital construction services. At Strata, he leads a specialist engineering team providing expert planning, BIM services, project controls, analytics, 4D visualisation, and delay analysis services.With over 20 years' experience across all construction sectors both national and global, he previously served as head planner for the €3 billion ESS project in Sweden. He holds an MSc in Engineering and Civil Engineering from UCD and an MSc in Construction Law and Dispute Resolution from King's College London.

Heather Mason, MA, MA, MSc, is the founder of The Minded Institute, The Yoga in Health Care Alliance, and joint founder of the APPG on Yoga. She holds master's degrees in Buddhist Studies, Psychotherapy, Medical Physiology, and has extensive education in Neuroscience. Heather has been a yoga teacher since 2001 and specialised in yoga therapy for mental health since 2007. As a world leader on this topic, Heather has lectured at universities from Harvard to UCL and at an array of academic conferences around the world. She was the first person in the UK to train with the Boston Trauma Center to offer yoga for trauma, launched a yoga programme at The Maudsley's Traumatic Stress Service, and has been training others in yoga therapy for PTSD since 2012. In 2023 Heather co-created the world's first yoga therapy psychotherapy accredited training programme.The Minded Institute WebsiteSupport the show

 A Hosea and Gomer retelling... in Nigeria?  Yes, please! Listen in and learn about IyanuOluwa's inspiration, love of words, and love of the Lord and his people in Love's Beacon. note: links may be affiliate links that provide me with a small commission at no extra expense to you.  I had a lovely time chatting with IyanoOluwa about her The Way Home series and how she weaves faith, Nigerian culture, and Biblical inspiration into her contemporary romance stories.  Love's Beacon by IyanuOluwa Olorode Goal/Wish List Mini Cooper that I didn't buy with my own money. Check. MSc from London College of Fashion. Check. Become a millionaire, not just because of dad's money. Check. Have at least five thriving businesses. Check. Get married to the love of my life. FUTURE IMPOSSIBLE TENSE! Regina has everything she possibly wants. At least almost everything. Two things elude her. One. Dapo. Dapo is all shades wrong and not hers. He's her sister's man, yet her heart can't stop beating for him. Why? Maybe because he has the other one thing she knows she can never have—a relationship with God. Something she once had but foolishly threw away. Rachel is wife material. Not just any wife material. Pastor's wife material. She's godly, calm, and reserved. She loves the Lord, and she's pretty enough that they'd both look good on a church poster. Dapo's plan to become the youngest youth pastor at Solid Rock Assembly is set in motion and meets an abrupt end when his fiancée marries Brother Bisola instead. Enraged and heartbroken, Dapo finds himself nursing a heartbreak and feelings towards his best friend's baby sister, Regina. Regina is all shades wrong. She's loud, impulsive, has close to zero interest in the things of the Lord, wears skimpy clothes, and is too beautiful for her own good. Despite all the red flags, he can't stop himself from loving her. And three words ring loud and clear: RECIPE FOR DISASTER. Regina believes in fate. Could it be fate bringing them together? Or is there something else, something more powerful intent on weaving something marvellous out of that disaster? Love's Beacon is a Nigerian contemporary loose retelling of the Hosea and Gomer story. Learn more about Iyanu on her WEBSITE and follow her on GoodReads and BookBub. Like to listen on the go? You can find Because Fiction Podcast at: Apple Castbox Google Play Libsyn RSS Spotify Amazon and more!

The Golden Crew is dreaming beyond Carnival! Join Trevor, Tom, and Jenn as they share which cruise lines are on their bucket lists (spoiler: Tom wants to try the Scientology ship for the "experience"). This week: Trevor's declining a bad book deal to self-publish his hockey romance "Second Shot," Tom's convinced he's been kicked out of the group chat (he hasn't), and we debate the merits of MSC's yacht club where you get your own butler named Jeeves. Plus, we discover Virgin's annual pass costs $120,000, Tom wants to bathe in champagne in a hot tub, and we explore Margaritaville's retirement communities where everyone goes "fins up!" We also thank our listeners for NOT getting us mentioned in John Heald's influencer post because we definitely don't want that responsibility. Fair warning: This episode contains dangerous levels of butler voice impressions and math that doesn't add up.

Show Notes: Simon Western is joined by Yoko Kunii Aldous - lecturer, coach, hypnotherapist and cultural translator - to explore the deeper roots of this Japanese concept, revealing it to be less a “life purpose formula” and more a way of being-in-the-world.  Yoko reflects on her journey from Japan to the UK and how living between languages and cultures opens up inner landscapes. She shares the real history of Ikigai - not as a productivity hack, but a pre-capitalist way of locating oneself in community and cosmos - and interrogates why the popular Western Venn diagram (“what you love, what you're good at…”) oversimplifies and erases its cultural nuance. Drawing on Japanese concepts, Yoko frames language as a worldview where nature, spirit, and objects are integral to self-understanding. She speaks of spirituality in everyday life - from cherry blossoms to chopsticks - and explains why Ikigai should be seen as fluid, shifting across life stages and relationships, rather than as a fixed endpoint. The conversation explores the tension between individualism and collective responsibility, asking whether one can truly have Ikigai without caring for the village. From embracing imperfection through wabi-sabi, to recognising sacrifice and service as pathways to fulfilment, the episode challenges Western coaching to move beyond self-improvement toward a more relational, ecological, and culturally entangled way of living. Key Reflections: True Ikigai cannot be pinned down or defined - it must be lived Culture shapes not only what we think, but how we feel our way into meaning Japanese aesthetics embrace imperfection (wabi-sabi) as essential to beauty and purpose Spirituality in Japan is woven into the everyday - from teacups to trees Personal meaning and collective wellbeing are not separate projects Every item has a spirit Keywords: Ikigai, cultural insights, coaching, psychology, Japan, Western perspectives, personal development, spirituality, Venn diagram   Brief Bio: Yoko Kunii Aldous is an award-winning university lecturer, coach, and language and culture trainer for the Ministry of Defence. She holds an MA in Applied Linguistics and an MSc in Coaching Psychology, and is a certified coach, hypnotherapist, and yoga instructor. Her background in language and communication informs her work in higher education, cross-cultural training, and personal development coaching. Her latest research explores how the Japanese concept of Ikigai is understood and applied by non-Japanese coaches. Her study critically examines how Ikigai is interpreted and integrated into coaching practices outside Japan, revealing common misconceptions and promoting a more culturally authentic understanding. This work was recognised with the Best Early Career Research Paper award by BPS Division of Coaching Psychology. By integrating Eastern philosophy with Western psychological theory, Yoko offers a coaching approach that is reflective, holistic, and grounded in cultural nuance. She supports individuals and professionals in aligning their core values with purposeful action, towards meaningful and sustainable change.

Send us a textHello, passionate cruisers! This is Paul. This week on The Joy of Cruising Podcast, I am proud to welcome Alissa Musto, Recording Artist, Singer, Pianist, Actor, Miss America Finalist. And Alissa performs as a guest entertainer onboard cruise ships. I am as passionate about music and comedy as I am about cruising so when I get a chance to have a conversation with an entertainer who also has performed on cruise ships, I am in my glory. What a resume! Alissa's website describes her as “Retired pageant queen playing piano around the world,”A Musician, Singer-Songwriter, Actor, Miss Massachusetts 2016 & Miss America Finalist, World Traveler, Vanlifer, Sailor, Reality TV Contestant, Harvard 2016, University of Miami (MM?) 2019, and, 30 under 30. Wow, I want to hear about it all. Of course, what we on The Joy of Cruising Podcast, most want to hear about is Alissa being a guest entertainer for Holland America, Princess, Celebrity, MSC and Norwegian Cruise Lines. Alissa has dazzled audiences while sailing through over 50 countries. The song quickly hit 20,000 views on Facebook and Alissa's story was featured in Conde Nast Traveler, GEN (a Medium publication), The Washington Post, the cover page of The Herald News, NBC Boston, Good Morning America and ABC's national lifestyle network, Localish.Do you have a dream car?Support the showSupport thejoyofcruisingpodcast https://www.buzzsprout.com/2113608/supporters/newSupport Me https://www.buymeacoffee.com/drpaulthContact Me https://www.thejoyofcruising.net/contact-me.htmlBook Cruises http://www.thejoyofvacation.com/US Orders (coupon code joyofcruisingpodcast)The Joy of Cruising https://bit.ly/TheJoyOfCruisingCruising Interrupted https://bit.ly/CruisingInterruptedThe Joy of Cruising Again https://bit.ly/TheJoyOfCruisingAgainIntl Orders via Amazon

Do you sometimes wonder about your relationship with alcohol? Should you drink less? Or not at all?What does a “healthy” relationship with alcohol look like?The answers may surprise you.On this episode I'm joined by Colleen Freeland, an intuitive drinking coach, Founder of Emotional Sobriety Coaching©, and host of the top-ranked It's Not About the Alcohol podcast, for a conversation about women, wine, and the emotional patterns that often drive our drinking habits.Colleen shares her own story of secretly struggling with alcohol use disorder for over 20 years and the solutions she discovered to create emotional sobriety for herself. She says it's about so much more than just the drink in our hand. Much like emotional eating, it's really about de-coding our emotional cravings and learning to tune in to what we're truly seeking.Key Takeaways:What intuitive drinking looks likeWhy willpower doesn't work, and what doesHow to tune into your body's needs instead ‘numbing out' with alcoholHighlights: 05:02 "Understanding Alcohol Use Disorder"13:45 ‘Gray Area' Drinking 18:45 Sober Identity26:03 Different Approaches to Alcohol RecoveryImportant Links

Dr Jen Unwin  Dr Jen Unwin. BSc, MSc, DPsy, C Psychol, FBPsS Consultant Clinical Health Psychologist. Past Chair UK Association for Solution Focused Practice. Winner of the British Psychological Society Karen Ehlert Lifetime achievement award in clinical health psychology. Co-founder of Food Addiction Solutions. Dr Jen Unwin has spent her professional life interested in the role of hope in chronic disease and how it can be used to bring about behaviour change.  Her insights teamed up perfectly with Dr David Unwin's interests in bringing about drug-free type 2 diabetes remission. For over 13 years they have been running group sessions in primary care to achieve just that, so far for more than 150 patients.  Both doctors were featured in a BBC TV documentary ‘The truth about carbs' that was seen by 3.7 million viewers.  Jen has written a book ‘A Fork In The Road' and is part of a team that published the first ever treatment study in the field and co-ordinated an international expert consensus on food addiction. Link to Show Notes on Website https://fabulouslyketo.com/podcast/242. Dr Jen’s Books Fork In the Road – Dr Jen Unwin Fork in the Road – A 100 Day Journey to Food Freedom Personal Progress Journal – Dr Jen Unwin and Heidi Giaever Dr Jen’s Top Tips Curate your environment . It's easy but it's not simple – be kind to yourself if you slip up. For food addiction – get some sort of support. Resources Mentioned Books “Wheat Belly” by Dr. William Davis Discussed in the context of wheat activating the brain's reward centers like cocaine. “Food Noise” by Jack Mosley Written by Michael Mosley's son; explores food addiction and GLP-1 medications. “Rewire Your Food-Addicted Brain” by Dr. Claire Wilcox Subtitle: Fight Cravings and Break Free from High Sugar Ultra-Processed Diet Using Neuroscience Covers cravings, the addicted brain, and breaking the cycle. Podcasts & Platforms Food Junkies Podcast Hosted by Vera Tarman and team. Interviews leaders in food addiction recovery. Jen mentioned Molly and Chrissy from Sweet Sobriety, who are also involved in the podcast. Research & Tools Yale Food Addiction Scale (YFAS) A validated tool for assessing food addiction symptoms. Craved Questionnaire Developed by Jen and team based on the 6 criteria for substance use disorder. For clinicians screening for food addiction. Frontiers in Psychiatry – Special Issue on Food Addiction Jen co-edited this academic journal issue with 15 papers (10+ already published). A second volume will be published in Frontiers in Public Health. Connect with Dr Jen Unwin on social media Twitter: https://x.com/drjenunwin YouTube: https://www.youtube.com/@FabulouslyKeto Website Details: https://www.the-chc.org/fas Remember to use TFKP coupon code for a 40% Discount The Fabulously Keto Diet & Lifestyle Journal: A 12-week journal to support new habits – Jackie Fletcher If you have enjoyed listening to this episode – Leave us a review By leaving us a review on your favourite podcast platform, you help us to be found by others. Support Jackie Help Jackie make more episodes by supporting her. If you wish to support her we have various options from one off donations to becoming a Super Fabulously Keto Podcast Supporter with coaching and support. Check out this page for lots of different ways to support the podcast. https://fabulouslyketo.com/support Or You can find us on Patreon: https://www.patreon. com/FabulouslyKeto Connect with us on social media https://www.facebook.com/FabulouslyKeto https://www.instagram.com/FabulouslyKeto1 https://twitter.com/FabulouslyKeto https://www.youtube.com/@FabulouslyKeto Facebook Group: https://www.facebook.com/groups/FabulouslyKeto Music by Bob Collum Recommend a guest We would love to know if you have a favourite guest you would like us to interview. Let us know who you would like to hear of if you have a particular topic you would like us to cover. https://fabulouslyketo.com/recommend-a-guest We sometimes get a small commission on some of the links, this goes towards the costs of producing the podcast.

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc is joined by co-authors Marc G. Dubin, MD, and Spencer C. Payne, MD, to discuss the Clinical Practice Guideline "Adult Sinusitis Update,” which published as a supplement to the August 2025 issue of Otolaryngology–Head and Neck Surgery. The guideline addresses diagnostic accuracy for adult rhinosinusitis, use of ancillary tests to confirm diagnosis and guide management, and systemic and topical therapy. Click here to read the full article.

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc is joined by co-authors Margo McKenna, MD, and Maria Colendrea, DNP NP-C, to discuss the implications for non-otolaryngologists of the Clinical Practice Guideline "Adult Sinusitis Update,” which published as a supplement to the August 2025 issue of Otolaryngology–Head and Neck Surgery. A plain language summary of the guideline was published in the August 2025 issue as a companion to the full guideline.  Click here to read the full article. 

Living a Nutritious Life PodcastIn this exciting episode of Living a Nutritious Life Podcast, we are thrilled to welcome Dr. Bojana Jankovic Weatherly.About Our Guest: Dr. Bojana Jankovic Weatherly, MD, FACP, MSc, IFMCP, is a double board-certified physician in internal and integrative medicine, certified in Functional Medicine, and founder of BOJANA MD, a boutique integrative medicine practice offering personalized, evidence-based care. Full bio here.What You'll Learn in This Episode:- Dr. Bojana's personal journey from conventional primary care to launching her own integrative practice.- The fundamentals of an integrative approach, including why patient partnership and individualized care plans are critical for optimal outcomes. - PCOS demystified: what it really is & why diagnoses may appear to be on the rise.- Nutrition, lifestyle, supplements, medication—how Dr. Bojana combines these tools for sustainable PCOS management.Episode Highlights: - Dr. Bojana's paradigm shift: From burnout to empowerment through integrative care.- How to bridge the gap between conventional and functional medicine in clinical settings.- PCOS explained—diagnosis, understanding metabolic roots, and why it's not just about ovarian cysts.- Treatment toolbox: Birth control, inositol, GLP-1s, nutrition strategies, and the “big picture” approach to PCOS.About Living a Nutritious Life Podcast: Welcome to Living a Nutritious Life podcast with Keri Glassman, MS, RDN, CDN, where we break down the latest nutrition science into smart, actionable tips to help you live your most nutritious life.Keri and her world-renowned guests cut through the noise, sharing unparalleled, forward-thinking tips, tricks, and the latest in health, wellness, and nutrition science.Based on Keri's whole-person approach to healthy living, each impactful episode extends far beyond the simplistic “get more sleep” and “eat your greens” advice. She connects the dots like no one else.Listen as Keri and her expert guests explore the physiological and behavioral connections that explain, for example, why the common wisdom around dieting and exercising alone doesn't work, so you can finally make the meaningful changes you've been looking for.If you found value in this episode, please RATE, REVIEW and SHARE.Get in on the action—enroll in our Become a Nutrition Coach program at nutritiouslife.com/bnc.Connect with Dr. Bojana on Social: Instagram: https://www.instagram.com/dr_bojana/Facebook: https://www.facebook.com/drbojana/LinkedIn: https://www.linkedin.com/in/bojana-jankovic-weatherly-md-facp-msc-ifmcp-7054a378/SoMeDocs Obesity Medicine Virtual Conference: https://doctorsonsocialmedia.com/obesity-medicine-2/?aff=drbojanaWebsite: https://drbojana.com/https://drbojana.com/conditions-we-treat/https://drbojana.com/new-patient-application/Articles:https://drbojana.com/pcos-what-symptoms-and-signs-you-should-look-for-and-how-to-diagnose/https://drbojana.com/nutritional-interventions-for-pcos/https://drbojana.com/supplemental-recommendations-for-individuals-with-pcos/https://drbojana.com/pharmacotherapy-for-individuals-with-pcos/Connect with Keri on social: Instagram: https://www.instagram.com/nutritiouslifeofficial/ Website: https://nutritiouslife.com/ Become a Nutrition Coach: https://nutritiouslife.com/bnc/Copyright © 2023-2025 Nutritious Life.#LivingaNutritiousLife #NutritiousLife Hosted on Acast. See acast.com/privacy for more information.

游轮重度爱好者的我们又做了一次游轮！这次选的是NCL公司，坐过之后就算是集齐最普遍的三大游轮公司勋章，来给大家分享一下我们的横评！[1:05] 6次游轮经历都是哪儿？[5:40] 游轮线路其实比公司更重要，线路梳理：美洲、欧洲、亚洲、大洋洲[14:00] 为什么我们选择去地中海和北欧坐游轮？[17:50] 邮轮公司大比拼（NCL，皇家加勒比，MSC，歌诗达）之美食天堂和地狱[32:20] NCL Prima/MSC Eurobia/RC Oasis of the Sea三艘大船：从电梯到泳池娱乐儿童托管[42:40] 游轮健身房点评（可能只有这个频道有了吧[46:40] 美国平权的梦想我在皇家加勒比上真的看到了:)[51:00] NCL服务差到我每天都在闻崽姐的粑粑味[1:08:00] 看到鲸鱼的那一点小震撼相关内容：详见小宇宙专题管理《04 旅行voice log》 每一场旅行都有太多故事Ep.40 地中海游轮旅行，从五渔村到Capri，现在我们只能望梅止渴Ep.121 今天旅行规划你有了吗？游轮攻略给你们出好了！Ep.159 “捡便宜”的阿联酋抠门旅行，就是每天都期待着旅行的结束【关于Passion Fruits】欢迎来到一对普通夫妻Eric和莎莎的Marriage Therapy从恋爱、结婚、生娃，万事都在改变，但我们希望不变的是我们内心对于喜爱事物的热情。所以Passion Fruits不是百香果，是我们用对生命的热情去探讨健康的生活方式、自我追寻的旅途，还有日常的那些碎碎念。【主理人】Eric：15年篮球玩家退役 10年康复撸铁 4年赛车手 2年Crossfiter 1年铁三运动员莎莎：藤校毕业创业5年的yogi MomentZ迷之创始人微博小红书抖音如果有就都是@莎莎Pluss@楼长Eric听友群vx+：momentz0518

Are energy drinks hijacking your brain? And your kids?They promise a high, but at what price?IT'S NOT JUST A DRINK; IT'S A DAILY HIT TO THE NERVOUS SYSTEM.A dopamine hit now that could lead to anxiety, crashes and sleep issues later.One can = up to 300mg of caffeine. That's 2-4 coffees in a single hit. Then add sugar and taurine. This is the buzz that might be blocking sleep, spiking dopamine, raising cortisol, increasing mood swings and leading to burnout.What starts as a boost can become a brain imbalance.And one can is rarely the only one. So, what if your boost or your kid's ‘buzz' is silently burning out yours and their brains?"Protect your brain. Protect your health.Tag someone who needs to hear this. Dr. Verena, PhD, MSc, is a neuro-trained kinesiologist, scientist, and integrative health expert. Fusing Western nutrition with Eastern medicine, she works to guide people back to true vitality across mind, body, and spirit.An acclaimed academic, clinician, author, international speaker, and retreat facilitator, her work is a culmination of over two decades of groundbreaking research, teaching, and clinical practice. FULL VIDEO:HTTPS://YOUTU.BE/1RTFVSTBKKGFOR MORE INSPIRATION:https://www.instagram.com/janeapplegath/YOUTUBE: https://bit.ly/4jqFLbiSpotify, iTunes and more. https://bit.ly/3Ey8bAW

Divaka Perera, MD and F. Aaysha Cader, MBBS, MD, MSc, FACC discuss the SERIAL study, the first randomized comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in serial coronary artery disease.

Mehdi H. Shishehbor, DO, MPH, PhD, FACC and F. Aaysha Cader, MBBS, MD, MSc, FACC discuss the analysis of 1-Year Outcomes of Transcatheter Arterialization of Deep Veins: PROMISE II and Pooled PROMISE Studies.

Mehdi H. Shishehbor, DO, MPH, PhD, FACC and F. Aaysha Cader, MBBS, MD, MSc, FACC discuss the analysis of 1-Year Outcomes of Transcatheter Arterialization of Deep Veins: PROMISE II and Pooled PROMISE Studies.

Divaka Perera, MD and F. Aaysha Cader, MBBS, MD, MSc, FACC discuss the SERIAL study, the first randomized comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in serial coronary artery disease.

In a popular re-release, Jessie Inchauspé, the Glucose Goddess, joins Dr. Mindy to explore the critical role of glucose regulation for holistic health. Their discussion covers the impact of glucose on mental and physical well-being, the significance of good nutrition, and simple strategies for consistent glucose levels. They also delve into the influence of the food marketing industry, the guidance provided by medical professionals regarding health choices, and the effects of supplements. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit https://drmindypelz.com/ep299 Jessie Inchauspé is a French biochemist and New York Times bestselling author. She is on a mission to translate cutting-edge science into easy tips to help people improve their physical and mental health. In her books Glucose Revolution and The Glucose Goddess Method, which sold over 1 million copies worldwide in 40 languages, she shares her startling discovery about the essential role of blood sugar in every aspect of our lives, and the surprising hacks to optimize it. Jessie is the founder of the popular Instagram account @GlucoseGoddess, where she teaches over 3 million people about transformative food habits. She holds a BSc in mathematics from King's College, London, and an MSc in biochemistry from Georgetown University. Check out our fasting membership at https://esetacademy.drmindypelz.com. Please note our medical disclaimer.

Welcome to the thirty-fourth episode of the Zoology Ramblings Podcast! In this special episode, Emma and Robi answer their most commonly asked question: how did you get into zoology/conservation? Emma and Robi offer a personal dive into their professional pathways, looking at how they got into the jobs they are in now, outlining the challenges of the environmental sector and what makes it all worth it. Emma and Robi also share some news to start, including welcoming our first Patreon members - thank you for supporting the podcast! Robi gives an update about the silver-backed chevrotain, which now has its own conservation breeding programme. Emma explores the first documented case of tool use in orca, talking about how orca are using kelp to mutually remove parasites from each other. Robi also talks about the exciting African Parks Rhino Rewild initiative, which has see 70 southern white rhinos transferred from South Africa to Rwanda. For their species of the week, Emma talks about the basking shark and Robi discusses the forest-dwelling Guam kingfisher. Robi Watkinson is a Conservation Biologist and wildlife filmmaker specialising in the spatial and movement ecology of large carnivores, camera trapping survey methods, rewilding, metapopulation dynamics and conservation planning. He has an MSc in Conservation Biology from the FitzPatrick Institute of African Ornithology, and the Institute of Communities and Wildlife in Africa, University of Cape Town. He is based between Cape Town and London, and has strong interests in equitable and inclusive conservation, palaeontology and wildlife taxonomy and evolution!Emma Hodson is a Zoologist and wildlife content creator, currently working in the community and engagement team at Avon Wildlife Trust. Emma's role as a Wildlife Champions Project Officer involves supporting and upskilling people to take action for nature in their local communities. Emma has experience in remote wildlife fieldwork, and has been part of Arctic fox, macaw and cetacean research teams in Iceland, Peru and Wales respectively. She has also been involved in animal care and rehabilitation work in Costa Rica and South Africa. Emma is particularly passionate about the interface between community engagement and wildlife monitoring, and enjoys running workshops and giving talks on topics including camera trapping, beaver ecology and rewilding. You can watch "Rewilding A Nation" for free on WaterBear by following this link: https://www.waterbear.com/watch/rewilding-a-nation . You can follow more of our weird and wonderful wildlife adventures on instagram: @zoologyramblingspodcast & @robi_watkinson_wildlife & @emma_hodson_wildlife

In this essential solo episode, Dr. Marianne challenges the narrow and harmful narrative that eating disorders primarily affect girls and women. She explores how toxic masculinity shapes, and often hides, disordered eating and body shame in boys and men. Backed by recent research, this episode unpacks how muscle dysmorphia, bingeing, and restriction are frequently dismissed as “normal” male behaviors, even when they reflect deep emotional pain. Dr. Marianne offers a liberation-focused framework for understanding the unique barriers boys and men face in getting help, and how we can dismantle the systems that reinforce silence, shame, and suffering. CONTENT CAUTION:This episode includes discussion of eating disorder behaviors, muscle dysmorphia, trauma, and toxic masculinity. Please take care while listening. WHAT YOU'LL LEARN IN THIS EPISODE: How toxic masculinity discourages emotional expression and reinforces disordered eating Why boys and men with eating disorders are often undiagnosed or misdiagnosed What muscle dysmorphia is and how it manifests in teen boys and adult men How social media trends like “looksmaxxing” fuel body obsession and psychological distress The role of trauma, emotional suppression, and performance culture in male ED experiences How clinicians, caregivers, and educators can support male-identified folks through a liberationist lens What affirming, emotionally honest healing can look like outside of gendered expectations LISTEN TO OTHER EPISODES ABOUT MEN, MUSCULARITY, & EATING DISORDERS: Men, Muscularity, Exercise, & Eating Disorder Stigmas with George Mycock, MSc @myo_minds on Apple & Spotify. Muscularity-Oriented Issues, Men, & Eating Disorders with MyoMinds' George Mycock, MSc on Apple & Spotify. Men, Eating Disorders, & Body Image with Jonny Landels, Certified Nutritionist & Personal Trainer on Apple & Spotify. RESOURCES & LINKS: Work with Dr. Marianne: www.drmariannemiller.com Follow on Instagram: @drmariannemiller RATE & REVIEW: If this episode spoke to you, please consider leaving a 5-star review and sharing it with your community. Your support helps amplify these critical conversations and brings liberation-based eating disorder care to more people. INTERESTED IN HANGING OUT MORE IN DR. MARIANNE-LAND? Follow me on Instagram @drmariannemiller Check out my virtual, self-paced ARFID and Selective Eating course Look into my self-paced, virtual, anti-diet, subscription-based curriculum. It is called Dr. Marianne-Land's Binge Eating Recovery Membership. Check out my blog. Want more information? Email me at hello@mariannemiller.com

In this episode, we discuss assessment and treatment of common conditions that we may see within the ankle/foot region. We explore: Lateral ankle/foot painCuboid SyndromeChronic ankle instabilityImaging to assess subtalar joint dysfunctionLateral ankle sprain assessment and managementHigh ankle sprain assessmentManagement of full thickness ATFL tearsWant to learn more about the ankle? Dr Chris Bleakley has done a brilliant Masterclass with us called “Ankle Sprain: Etiology, Diagnosis and Rehabilitation” where they go into further depth on this topic. 

AEM Podcast host Ken Milne, MD, and guest skeptic Suchismita Datta, MD, interview lead author Rachel E. Solnick, MD, MSc. Learn more in the accompanying Hot Off the Press article available in The Skeptics' Guide to Emergency Medicine.

In this episode of The Dairy Podcast Show, Dr. Vern Osborne from the University of Guelph explores the critical yet often overlooked role of water in dairy herd health and performance. From nutrient supplementation through water to improving water quality and facility design, Dr. Osborne offers practical advice for optimizing dairy operations. Tune in now on all major platforms!"Cows are incredibly sensitive to water quality, detecting elements at parts-per-million levels."Meet the guest: Dr. Vern Osborne is a Professor Emeritus in the Department of Animal Biosciences at the University of Guelph. He holds both an MSc and PhD from the University of Guelph and is internationally recognized for his expertise in dairy nutrition and facility design. With a career spanning over 36 years, Dr. Osborne's research focuses on optimizing water nutrition and developing innovative feeding strategies to enhance dairy cow productivity.  He also serves as the Science and Design Lead for the Mission 2050 project, which reimagines modern livestock research facilities.Liked this one? Don't stop now — Here's what we think you'll love!What you'll learn:(00:00) Highlight(01:24) Introduction(05:45) Water as a nutrient(06:40) Transition cow feeding(10:59) Optimizing water quality(17:51) Designing dairy facilities(21:21) Nutrient delivery systems(26:24) Final three questionsThe Dairy Podcast Show is trusted and supported by innovative companies like:* Evonik* Adisseo* Lallemand* Priority IAC- dsm-firmenich- ICC- AHV- Protekta- Natural Biologics- SmaXtec- Berg + Schmidt

In this Red Mills Feed Room Classic, Spike is back in the Feed Room with Louise Jones, a nutritionist at Connolly's RED MILLS, to talk through what you should and shouldn't have in your feed room, along with some key hygiene tips to help you prevent a positive drug test.   Guests: Louise Jones: In 1999, Louise qualified with a BSc (Hons) in Equine Science, during which she specialised in breeding science and went on to graduate with an MSc in Equine Science in 2000. She is also one of only a handful of registered equine nutritionists in the UK. She has an extensive understanding of stud, clinical and performance horse nutrition, and has worked with trainers and breeders in the UK, Continental Europe, and the Middle East.    Sponsors: Connolly's Red Mills are offering 15% off Foran Equine products to Eventing Podcast listeners! Use the code EquiRatingsPodcast15 to receive your discount. View the full collection here.   If you have any other questions regarding feeding click here to ask the Connolly's RED MILLS experts.    

Burnout is impacting people all over the globe. It is not respecter of person. It has the potential to be debilitating on many different levels. Carrie M. Hersh, DO, MSc, FAAN shares her very personal journey through burnout to wellness..She is a specialist in multiple sclerosis and neuroimmunology at Cleveland Clinic Lou Ruvo Center for Brain Health (CCLRCBH). She is also an Associate Professor of Neurology at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CWRU).

About this episode:  In early July, the CDC deactivated the United States' H5N1 emergency response, citing lowered rates of infection among animals and humans. But fewer cases might not indicate an end to the years-long emergency. In this episode: Dr. Erin Sorrell of the Johns Hopkins Center for Health Security details the timeline of the virus, its impacts on American farmers, and how to prepare for the return of migratory birds later this year. Guest: Dr. Erin Sorrell, PhD, MSc, is an associate professor at the Johns Hopkins School of Public Health Department of Environmental Health and Engineering and senior scholar at the Johns Hopkins Center for Health Security. Host: Stephanie Desmon, MA, is a former journalist, author, and the director of public relations and communications for the Johns Hopkins Center for Communication Programs. Show links and related content: As bird flu evolves, keeping it out of farm flocks is getting harder—ScienceNews RFK's proposal to let bird flu spread through poultry could set us up for a pandemic, experts warn—Live Science Bird Flu Is Escalating—Public Health On Call (January 2025) Transcript information: Looking for episode transcripts? Open our podcast on the Apple Podcasts app (desktop or mobile) or the Spotify mobile app to access an auto-generated transcript of any episode. Closed captioning is also available for every episode on our YouTube channel. Contact us: Have a question about something you heard? Looking for a transcript? Want to suggest a topic or guest? Contact us via email or visit our website. Follow us: @‌PublicHealthPod on Bluesky @‌JohnsHopkinsSPH on Instagram @‌JohnsHopkinsSPH on Facebook @‌PublicHealthOnCall on YouTube Here's our RSS feed Note: These podcasts are a conversation between the participants, and do not represent the position of Johns Hopkins University.