Podcasts about european bioinformatics institute

In this week's episode of the Everything Epigenetics podcast, I'm joined by Dr. Charles Breeze, an expert in computational epigenetics. We talk about his inspiring journey into the field of epigenetics, his trailblazing research on kidney function across diverse ethnic groups, and the innovative tools he's developed to push the boundaries of epigenetic research.Dr. Breeze shares how his fascination with the complex interaction between environmental and genetic factors shaped his path into epigenetics. This passion led him to focus on understanding why certain populations are at higher risk for diseases like chronic kidney disease. His work has uncovered insights into the disparities in kidney disease risk among different ethnic groups, shedding light on genetic and environmental factors that had previously been overlooked.To address the challenges of inclusivity and precision in epigenetic studies, Dr. Breeze developed specialized tools that enhance the accuracy of Epigenome-Wide Association Studies (EWAS). These tools aim to improve how we analyze the impact of genetics and environment on health, helping researchers study epigenetic patterns across populations more effectively. His contributions are making it easier to identify how factors like diet, stress, and pollution affect gene expression, paving the way for more inclusive and equitable health research.Dr. Breeze earned his Ph.D. in computational epigenetics and genomics from University College London, where he was a Marie Curie fellow. He has also worked at top institutions like the University of Oxford, the European Bioinformatics Institute, and the Altius Institute for Biomedical Sciences in Seattle. There, he led the analysis and creation of important mouse genome data. Dr. Breeze has developed bioinformatics tools like eFORGE and FORGE2, which help analyze data from studies on how genes and the environment affect health (EWAS and GWAS). Dr. Breeze is a member of the Encyclopedia of DNA Elements (ENCODE) and the International Human Epigenome Consortium (IHEC).You'll learn about:  - Dr. Breeze's early interest in genomics, sparked by reading "Genome" by Matthew Ridley  - His significant findings from the 2021 study titled “Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci,” which revealed ethnic disparities in kidney function  - The challenges faced in epigenetic research due to the lack of diversity in reference data and how this impacts research outcomes  - Proposed solutions to increase diversity in epigenomic data, including community involvement and targeted data generation  - How his bioinformatics tools, eFORGE and FORGE2, assist researchers in understanding the complex data from EWAS and GWAS studies  - His future research directions, including studies on kidney cancer and the expansion of pathway analysis toolsSupport the showWhere to Find Us:Instagram Twitter Facebook Follow us on:Apple Podcast Spotify YouTube Visit our website for more information and resources: everythingepigenetics.com Thank you for joining us at the Everything Epigenetics Podcast and remember you have control over your Epigenetics, so tune in next time to learn more about how to harness this knowledge for your benefit.

Ewan Birney is the deputy director general of the European Molecular Biology Lab (EMBL) and  co-director of the European Bioinformatics Institute. In his research, Ewan combines his training in biochemistry with computer science, which made him one of the heroes of the human genome project. In this episode, he describes that an “emotional” understanding of science is often enough to have valuable discussions with experts in different fields, a concept that forms the basis of his diamonds-and-whiskers model of successful scientific teams. Ewan also explains how for him, problems have personalities, and why thinking about science while driving is a bad idea. And he discusses with us how “humans are a complicated species” can be all the scientific hypothesis you need for a grant application, and how Mendel – but not Darwin! – was an early data scientist. For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Twenty years ago, the Human Genome Project was completed. It unveiled a mostly complete sequence of the 3 billion pairs of building blocks that make up the code within every set of human chromosomes. These are the instructions that create humans. Almost all of human biology research uses the Human Genome Project's findings in some way, from understanding why some people are more likely to develop diseases than others, to uncovering the secrets of our ancestors and evolution. But for genomics to become a part of everyday medicine, paving the way for personalised medicines, the hard work is still ahead.Natasha Loder, The Economist's health editor and Geoff Carr, our senior editor for science and technology, reflect on the completion of the Human Genome Project in the early 2000s and the gaps that still remain. Natasha also visits the Wellcome Sanger Institute, to explore the next frontiers for genomics in medicine—she meets the outgoing director, Mike Stratton; the incoming director, Matt Hurles; and the boss of the European Bioinformatics Institute, Ewan Birney. Plus, Mathew Davies, an engineer at the Sanger Institute, and his team, discuss the challenges with storing and processing vast amounts of sequencing data. Alok Jha, The Economist's science and technology editor, hosts.To dive deeper on genomics, find our recent episode from the Third International Summit on Human Genome Editing, or explore the power of gene therapies, and also an explainer on how genomic sequencing works.If you love Babbage, why not work with us? We're hiring for an Assistant Audio Producer to work on the show. Apply by May 15th.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Twenty years ago, the Human Genome Project was completed. It unveiled a mostly complete sequence of the 3 billion pairs of building blocks that make up the code within every set of human chromosomes. These are the instructions that create humans. Almost all of human biology research uses the Human Genome Project's findings in some way, from understanding why some people are more likely to develop diseases than others, to uncovering the secrets of our ancestors and evolution. But for genomics to become a part of everyday medicine, paving the way for personalised medicines, the hard work is still ahead.Natasha Loder, The Economist's health editor and Geoff Carr, our senior editor for science and technology, reflect on the completion of the Human Genome Project in the early 2000s and the gaps that still remain. Natasha also visits the Wellcome Sanger Institute, to explore the next frontiers for genomics in medicine—she meets the outgoing director, Mike Stratton; the incoming director, Matt Hurles; and the boss of the European Bioinformatics Institute, Ewan Birney. Plus, Mathew Davies, an engineer at the Sanger Institute, and his team, discuss the challenges with storing and processing vast amounts of sequencing data. Alok Jha, The Economist's science and technology editor, hosts.To dive deeper on genomics, find our recent episode from the Third International Summit on Human Genome Editing, or explore the power of gene therapies, and also an explainer on how genomic sequencing works.If you love Babbage, why not work with us? We're hiring for an Assistant Audio Producer to work on the show. Apply by May 15th.For full access to The Economist's print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Kosuke Fujishimaさんをゲストに迎え、これまでの研究人生に触れながら研究雑談しました。Shownotes このShownotesは藤島さんからのコメント・修正を受ける前です。またコメント・修正を受け取り次第更新いたしますのでご了承ください。 (by tadasu) Kosuke Fujishima Fujishimaさんの一つ前のエピソード テラフォーマーズ 冥王代 tri-split tRNA RNA world仮説 目ブラスト 貴家悠 藤島さんと貴家さんの対談 高井研 vs 貴家さん 減数分裂 東京喰種トーキョーグール レベルE 44. XXXXXYYYYY (Researchat.fm) … レベルE解説エピソード Lynn J. Rothschild 火星のマグマは噴出するか？ … Nature Geo Science? 火星の海 テラフォーマーズ20巻 … どこに藤島さんいるのか正直特定できておりません… ロスチャイルド家 エンケラドゥス 質量分析 衝突マス Eリング decadal survey from NASA 高速衝突実験装置 ISS アストロバイオロジーの三大研究 … 生命の起源、生命の分布、人類の宇宙進出 東大の工藤先生 全自動メダカ飼育装置 宇宙メダカの論文 宇宙メダカ選抜テスト 某ショット … 人類は月には何年前に到達したんだっけ？ ケンタウルス座アルファ星 ブレイクスルー財団 鉛の板 Yuri Milner ブレイクスルースターショット計画 イーロン・マスク　… ep19 Neuron Maskを参照のこと SpaceX The Martian … いわゆるオデッセイ Andy Weir 過塩素酸 Soda Lakes 過塩素酸入り培地で育つ微生物 ATGCU … DNA/RNAの塩基 111. Mirror Image Biology … 鏡像異性体の回 鏡像異性体は味がするのか？ ラセミ化 深海の微生物にはラセマーゼが多い ホモキラル EBI … European Bioinformatics Institute Joana Pereira タンパク質の配列空間 … よく使うフレーズなのですが、適切な名前が思い浮かばない (tamaki) ふじしまさんが載っているJAXAの宇宙飛行士募集ページ … 「宇宙飛行士に転職だ」 宇宙飛行士選抜テスト こまささん … 藤島さんのお友達 「大西宇宙飛行士に、OB訪問だ。」JAXA宇宙飛行士候補者募集スペシャルムービー … ふじしまさんがOB訪問という形で大西宇宙飛行士インタビューしています Editorial Notes (fujishi) 実は今回は高校生の皆さんにリーチするという野望があったのですが、届いたのだろうか・・・(coela) おもしろすぎました。完全版shownotesはそのうちに(tadasu)

“There's no such thing as too many scientists” - Ben Perry Join host Bruno Giussani as he delves into the rationale and practice of large scale scientific collaborations. In this episode Ben Perry, medicinal chemist with DNDI (Drugs for Neglected Diseases Initiative) talks about the nature and successes of open science. Rolf Apweiler, co-director of the European Bioinformatics Institute that collects, analyses and distributes data to the worldwide scientific community, explains the challenges researchers face in accessing the data they need and the way EBI seeks to streamline the process. The Wellcome Trust's director Jeremy Farrar discusses the interconnectedness of the world and how frameworks for international collaboration are essential for the future especially in areas where the scientific and the political overlap. And Charlotte Warakaulle, director for International Relations at CERN, describes the “CERN model” and elaborates on its scientific and technological contributions to health. Guests: Ben Perry, Rolf Apweiler, Jeremy Farrar, Charlotte Warakaulle Host: Bruno Giussani Production CERN, Geneva: Claudia Marcelloni, Lila Mabiala, Sofia Hurst Whistledown Productions, London: Will Yates and Sandra Kanthal Copyright: CERN, 2022

Today we're talking about some exciting new developments in the area of comparative genomics. We are joined by Dr. Zamin Iqbal who is a Research Group Leader at the European Bioinformatics Institute and Dr. Grace Blackwell who is jointly at the European Bioinformatics Institute, in Zam's group and Nick Thomson's team at Wellcome Sanger Institute

Proteins are twirly, curly, dynamic structures. Crucial for life, complicated to study. Predicting protein structure has been tough but it's now easier as AlphaFold enters the scene. That doesn't mean that AlphaFold has solved all challenges, of course. AlphaFold was developed by DeepMind Technologies, a company that was bought by Google in 2014. Lots of protein puzzles remain. Dr. Janet Thornton from the European Bioinformatics Institute and Dr David Jones of University College London talk about what AlphaFold can do and what it cannot yet do. They look forward, backward and all around on this subject. He says, laughing, he has "extreme cautious optimism" about the prospects of this field. You can also find my feature story about protein structure prediction, which is the Nature Methods method of the year for 2021, here: https://www.nature.com/articles/s41592-021-01359-1 

Proteomes, the sequences of protein within the DNA of every living thing, are notoriously difficult to model. The usual chemical methods can take months, but a new computational model using the ability of artificial intelligence to learn the complex sequences is able to predict structures within a matter of hours. Thousands of protein structure predictions are now available on a public database for anyone to access. Understanding such proteins is seen as key to treating nearly all disease. It also hold the potential for improvements in fields as diverse as increasing crop resilience to climate change and biodegrading plastic on an industrial scale. Marnie Chesterton speaks with Demis Hassabis from Deepmind which developed the protein structure prediction system, and Janet Thornton from the European Bioinformatics Institute which holds the database. Genetic engineering, the promise and perils, is the subject of a new series with Matthew Cobb on Radio 4, called Genetic Dreams, Genetic Nightmares. He tells us about the dilemmas now faced by researchers who on the one hand have the potential to send terminator genes into malaria spreading mosquitoes – but who are also aware of the huge unknowns surrounding the release of such technology. Extreme weather events are becoming more frequent. Hayley Fowler has been researching the links between weather systems, climate change and the heat and floods we are currently experiencing. And could we reduce the incidence of SARS-Cov2 with a different vaccination strategy? Julia Gog has modelled different scenarios, as the number of infections continues to rise. A strategy to target those who are mixing the most, whether socially or through their employment, may be more effective than one targeting the most vulnerable.

In this episode, the team discuss the omnipresent technology of next-generation sequencing (NGS), which has seen the cost of sequencing a human genome go from $100 million to under $1000 in just two decades. We hear from the European Bioinformatics Institute's Dr Alex Almeida, who uses NGS techniques to examine the human microbiome. We also investigate the future of NGS and ask what will happen when we have sequenced absolutely everything?

Our end-of-year special guest is one of the U.K.’s top genomicists, Ewan Birney, Co-Director of the European Bioinformatics Institute at EMBL. He is also the non-Executive Director for Genomics England.  Ewan's perhaps best known for his work with the ENCODE consortium.

Dame Janet Maureen Thornton, DBE FRS FMedSci HonFRSC is a senior scientist at the European Bioinformatics Institute, part of the European Molecular Biology Laboratory. She is one of the world's leading researchers in structural bioinformatics, Jan Moore talks to her. See acast.com/privacy for privacy and opt-out information.

Irina Armean from the European Bioinformatics Institute discusses the gene ontology (GO) and how machine learning can play a role in evaluating protein protein interactions (PPIs).

A widely reported study published last week suggests that on average children at selective schools have more gene variants associated with higher educational attainment than children at non-selective schools. It also suggests that selective schools achieve better GCSE exam results because their selection procedures favour children with those genetic variants, and not because of the teaching and facilities at private and grammar schools. Adam Rutherford talks to the senior researcher Robert Plomin of the Institute of Psychiatry in London, and Ewan Birney, director of the European Bioinformatics Institute near Cambridge. John Goodenough invented the lithium ion battery, the power pack that makes our smart phones, tablets and laptops possible. At the age of 95, in his lab at the University of Texas, he's now working with colleagues such as Portuguese physicist Helena Braga on an even better next generation battery technology: one that could transform the prospects for electric vehicles and renewable energy storage. Roland Pease meets the jovial battery pioneer and his team. Hunting regulations in Sweden are having a profound effect on the behaviour of brown bears in the country. Since the 1980s, hunters are not allowed to shoot female bears with cubs. Historically, mother bears stayed with their cubs for 1.5 years but as hunting rates increased, mothers began to keep their offspring with them for an additional year. Now more than a third of mothers look after their cubs for 2.5 years. According to Andreas Zebrosser of the University of Southeastern Norway and Joanie van der Walle of the Universitie de Sherbrooke, hunting appears to be acting as a powerful evolutionary force on the species' reproductive behaviour.

Francesco Iorio is a senior bioinformatician working with Open Targets: a public-private initiative involving teams at the Wellcome Trust Sanger Institute, the EMBL – European Bioinformatics Institute, GlaxoSmithKline and Biogen, with the mission of exploiting Big Data for systematically identifying new therapeutic targets. Previously he was an ESPOD fellow in joint post-doctoral program between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute under the guidance of Julio Saez-Rodriguez and Mathew Garnett. If you have any comments or questions email us on stemcellsatlunch@kcl.ac.uk

What can genome science do for you? Chief Medical officer Dame Sally Davies recently published her annual report, issuing a plea for a revolution in the use of genetic information in the NHS. She wants DNA tests to be as routine as biopsies or blood tests. Adam chats to geneticist Ewan Birney, head of the European Bioinformatics Institute in Hinxton, about the potential uses and limitations of genetic testing. Pugs are set to become Britain's most popular breed in the next couple of years. Together with similar dogs, like bulldogs and Frenchies, they are classed 'brachycephalic', having short snouts and compact skulls which makes them susceptible to a breathing problems. Veterinary surgeon Jane Ladlow has studied 1,000 dogs to improve their health today and in future generations. Reporter Graihagh Jackson went to visit the team at Cambridge Veterinary School. To mark the forthcoming 200th anniversary of the publication of Frankenstein, a new edition has been created especially for scientists and engineers. Adam talks to editor David Guston, from Arizona State University about the lessons this cautionary tale contains for science today. Presenter: Adam Rutherford Producer: Michelle Martin.

The Ninth annual Florence Nightingale Lecture, given by Professor Dame Janet Thornton, European Bioinformatics Institute, Cambridge. Held on Thursday 21st April 2016. Florence Nightingale was a celebrated nurse who served the British Army during the Crimean War. Her ground-breaking use of data visualisation turned a spotlight on the terrible hospital sanitation, and brought the issue to the attention of the British establishment. She went on to epidemiological work in India, statistically proving the importance of sanitation to health. Her work is a testament both to the power of Statistics to change the world, and the broad range of backgrounds from which the contributors to the discipline are drawn. The Florence Nightingale Lecture aims to celebrate that diversity by inviting a distinguished speaker to lecture on a statistical topic of their choice, one which can inspire the current generation as Nightingale herself did.

The Ninth annual Florence Nightingale Lecture, given by Professor Dame Janet Thornton, European Bioinformatics Institute, Cambridge. Held on Thursday 21st April 2016. Florence Nightingale was a celebrated nurse who served the British Army during the Crimean War. Her ground-breaking use of data visualisation turned a spotlight on the terrible hospital sanitation, and brought the issue to the attention of the British establishment. She went on to epidemiological work in India, statistically proving the importance of sanitation to health. Her work is a testament both to the power of Statistics to change the world, and the broad range of backgrounds from which the contributors to the discipline are drawn. The Florence Nightingale Lecture aims to celebrate that diversity by inviting a distinguished speaker to lecture on a statistical topic of their choice, one which can inspire the current generation as Nightingale herself did.

Many diseases strike harder and more often in the winter, including major inflammatory conditions such as Type 1 diabetes, multiple sclerosis and rheumatoid arthritis. New research out this week has uncovered the reasons why: it turns out that our immune responses are heavily influenced by the seasons. Professor John Todd who led this new global study discusses the results and how this could influence the way we administer medicines in future. Organisms generate energy in all sorts of ways and it can happen in all sorts of weird places, such as deep sea hydrothermal vents, where bacteria takes nasty stuff such as Hydrogen Sulphide, and turn it into useful stuff such as amino acids. This is called chemosynthesis. But it turns out that it doesn't just happen in dark corners of the ocean. As tubeworm expert Nick Higgs explains we are learning that chemosynthesis is everywhere. Major Tim Peake begins his six-month mission to the International Space Station in November,. Ever since its inception, the question of 'what the ISS is for?' has been asked.. So, what sort of science does it deliver? Richard Hollingham reports from Alabama, in a secret NASA research bunker. Two years ago, a team led by Nick Goldman at the European Bioinformatics Institute in Cambridge successfully took a collection of important cultural artefacts, encoded them digitally, and then wrote them in DNA. These included Martin Luther King's "I have a dream" speech, and all the Shakespearean sonnets. He's now collaborated with artist Charlotte Jarvis to encode a new musical composition which will also form a new art installation Music of the Spheres. DNA's ability to store complex digital data appears close to a reality. Could it hold the key to permanent long term storage for anything? Producer Adrian Washbourne.