Predicting over/unders for every player on the Portland Trail Blazers roster with my friend Chuck, Charles Tuggle. How many points will CJ McCollum score per game? Will Damian Lillard set a new career high for made 3s? Is Jusuf Nurkic going to dish the most assists of his career? Music for Locked On Blazers by Drae Slapz. Find more of Drae's work here: https://ffm.bio/wowslapz Learn more about your ad choices. Visit podcastchoices.com/adchoices
The No. 9 ranked Oregon Ducks are back in action this weekend when they host Pac-12 North Rival California at Autzen Stadium on Friday night. What are the major storylines of this game and what are the chances we see a better performance on offense this weekend than the last few games? Matt Prehm, Erik Skopil, and Jared Mack discuss and preview the major storylines of this Oregon vs California football game. Subscribe to our YouTube page and be entered to win a free one-year subscription to DuckTerritory! Make sure you like and subscribe to the Autzen Audibles Podcast with Matt Prehm and Erik Skopil on iTunes by clicking here or any other podcasting app. Visit our iTunes page for this podcast and other previous episodes by clicking here. Please leave a review of our podcast on iTunes if you can! We record a podcast once a week during the off-season for football and then from the months of August to January we record two and sometimes three podcasts per week. Our podcasts are always heavy on Oregon football but we make it a point to also try and cover Oregon men's and women's basketball, recruiting for both sports, and any other major storyline in the world of Oregon athletics. Matt Prehm has covered Oregon football, basketball, and recruiting since 2009 and during that time he's covered three different head coaching searches by Oregon football, a Final Four in basketball, two different national championship games for Oregon football, and 10 recruiting cycles for both football and basketball. Erik Skopil has worked for DuckTerritory since December of 2016 and has covered a head coaching search for football, while also covering Oregon football's regular season, basketball, women's basketball, softball, and recruiting for all those sports. Sign up for the FREE DuckTerritory.com newsletter and get all your Oregon news sent directly to your e-mail inbox daily. Consider following DuckTerritory on Twitter, as well as our full-time writers Matt Prehm, Erik Skopil, and Jared Mack. If you're not a VIP subscriber to DuckTerritory.com, consider signing up and taking advantage of our FREE trial here. Learn more about your ad choices. Visit megaphone.fm/adchoices
On this week's ep we discuss Nickelodeon All Star Brawl, Super Monkey Ball, Metal Gear Solid 3 Remake rumors, the Resident Evil movie trailers and more! We end it off by predicting what the 6 nominees for Game of The Year will be at this year's Game Awards!Super Monkey Ball Banana Mania - 2:05Odens Sphere - 9:21Nickelodeon All Star Brawl - 14:01Twitch Leaked: 24:03MGS 3 Remake Rumors: 31:35Playstation Remake Incoming?: 37:05Resident Evil Movie Trailers: 42:45Monster Hunter Rise Not Getting Crossplay/save: 49:35Nagoshi Leaves Sega: 53:35Koichi Sugiyama Passes Away: 56:20Other News: 59:10Main Topic - Predicting Game Awards GOTY Nominees: 1:04:45Podcasts:Nerds At Large Gaming Podcast (New Episodes Every Monday)Apple: https://podcasts.apple.com/us/podcast/nerds-at-large-gaming-podcast/id1216300348Nerds At Large SpoilercastiTunes: https://podcasts.apple.com/us/podcast/nerds-at-large-spoilercast/id1246037914Nerds & DragonsPodbean: https://nerdsanddragons.podbean.com/Shows:Anime Gauntlethttps://www.youtube.com/playlist?list=PL09Jy20sWhtF5iZabuLvQnmzOXHPMRBR2SETTLE IT!Playlist: https://www.youtube.com/playlist?list=PL09Jy20sWhtFIwxXIv524CLJ9RWgijftkPokémon Shield NuzlockePlaylist: https://www.youtube.com/playlist?list=PL09Jy20sWhtEPfZNcg_D6Hfgqhe80LLfQNerds At Large PlaysPlaylist: https://www.youtube.com/playlist?list=PL09Jy20sWhtHOYCjsCqRykl65UTf-83gSBlog: https://nerdsatlarge.wordpress.com/Twitter: @NerdsAtLargeTwitch: twitch.tv/NerdsAtLargeGamingYouTube: youtube.com/nerdsatlarge
In the season 2 episode 1 of the Stocks and Sandals Podcast, Mike and DJ talk to Hunter Archibald, a Hedge Fund Manager, who predicted the GameStop squeeze. We talk about ways to identify a short squeeze, and if its worth doing. New episodes are released on Tuesday mornings and can be found anywhere you listen to podcasts! Join the Stock Dads Discord and gain exclusive access to: 1. FREE Personalized Financial Planning with a Financial Advisor from Perspective Wealth Planning Complete access to our exclusive Stock Dads Academy education program for beginner, intermediate, and advanced traders. A wide variety of educational resources and tools. Real-time alerts and ideas for stocks, options, crypto, forex, and real estate. Live Stocks and Sandals® podcast recordings and Q&A sessions with expert guests. The support of an entire community filled with like-minded dads. A heavily moderated, clean, spam-free, safe environment to learn, ask questions, and grow. An opportunity to network with other dads, entrepreneurs, small business owners, investors, etc. Tons of other awesome dad tips and tools (parenting, personal/professional development, entrepreneurialism, lawn care, home improvement, and more!). Raffles, cash prizes, giveaways, and so much more! For a free stock, use the links below. Robinhood App: http://join.robinhood.com/davidb831 Webull App: https://act.webull.com/pm/hzvYJLM8KHhr/crd/inviteUs/ If you would like to leave us a review, you can do that here: https://ratethispodcast.com/stocksandsandals
The Boston Celtics begin a long stretch of road games with their last week of the preseason schedule that will really test who they are as a team. John Karalis of Boston Sports Journal discusses the pitfalls and advantages of an early road-heavy schedule. Plus, after two preseason games, maybe Marcus Smart will play less actual point guard than we think. And then we predict how many triple doubles Jayson Tatum will have this season. Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices
With the NHL's opening-night roster deadline looming, Nick and Ann predict which of the Preds' "bubble" players will make the team, as well as the X-factor that could decide whether Philip Tomasino starts in Nashville or Milwaukee. Plus, the final takeaways from an impressive Predators preseason slate. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dan is joined by Jabari Ali Davis (@JabariDavisNBA) from the Never Meet Your Heroes and The Baseline podcasts for a deeeeep dive into the Los Angeles Lakers ahead of the 2021-22 NBA season. They discuss the LeBron James-Russell Westbrook fit, Anthony Davis-at-the-5, the potential for a defensive drop-off, rounding out the rest of the rotation, Carmelo Anthony, Dwight Howard, DeAndre Jordan, floor spacing, lineup possibilities and much, much, MUCH more. TIMESTAMPS⬇️
The Jaguars may have their best chance at victory on Sunday against the Tennessee Titans who are coming off a loss to the NY Jets. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Our brain isn't great at predicting outcomes. When we're faced with decisions or new circumstances, our brain goes directly to doubt and fear to keep us safe. If we have doubt and fear, then we won't take any new action, which assures our safety. If we don't manage our brains instead of them acting from default, we won't get closer to our goals. RESOURCES Calendar Masterclass for Lawyers CONNECT WITH ME On Instagram @dina.cataldo On LinkedIn WORK WITH ME Learn how here. If you enjoyed this podcast, please consider leaving a review on Apple Podcasts. It takes less than 90 seconds, and it really helps spread the word about this podcast. For transcripts, go to the show notes for episodes.
Friend of the show Derwin Gray has a new book! When did he have time to write it? We don't know! But he also found time to sit down with Skye and talk about it. Derwin says the Lord's Prayer isn't just a prayer, but an entire catechism of faith, a lesson in communing with God, and a call for the people of God to engage in issues of justice. He unpacks it all with Skye. And did scientists find the biblical city of Sodom? Have psychologists found the number one predictor of atheism? And a new study finds that young Brits are twice as likely to pray regularly than their elders! What's up with that?? Mike Erre joins Kaitlyn and Phil to parse the news of the day on this week's Holy Post! Did scientists find the biblical city of Sodom? [6:47] https://www.christianitytoday.com/news/2021/september/sodom-meteor-biblical-archaeology-tall-el-hammam-airburst.html Predicting atheism in adulthood [20:50] https://www.psypost.org/2021/10/new-psychology-research-identifies-a-robust-predictor-of-atheism-in-adulthood-61921 Young people in the UK are twice as likely as older people to pray regularly [35:27] https://www.bbc.com/news/uk-58681075 Other links: Mike Erre's podcast - https://voxologypodcast.com Interview with Derwin Gray “God, Do You Hear Me?” Lifeway: https://www.lifeway.com/en/product/god-do-you-hear-me-P005822396 Amazon: https://amzn.to/3my2Ooy Interview Start [50:12] Pastoral vision for prayer [54:54] The Lord's Prayer as a mini catechism [1:00:28] The kingdom & loving our neighbor [1:09:21] Christ as the treasure [1:16:42] The Holy Post is supported by our listeners. We may earn affiliate commissions through links listed here. As an Amazon Associate, we earn from qualifying purchases.
Justin and Peter talk about the Switch OLED Model, the rumors about Kojima's potential Silent Hill game, make our predictions for the Game Awards nominations, and more all while having a hoot and a holler!Nintendo Switch OLED hands-on: The best upgrade may not be the screen // CNET // Dan Ackermanhttps://www.cnet.com/tech/computing/hands-on-the-best-upgrade-on-the-new-oled-nintendo-switch-may-not-be-the-screen/Hideo Kojima Reportedly Developing Silent Hill PS5 Exclusive // ComicBook.com // Tyler Fischerhttps://comicbook.com/gaming/news/hideo-kojima-silent-hill-ps5-playstation-5-exclusive-game/Silent Hill PS5 Exclusive From Hideo Kojima Potentially Debunked by Insider // ComicBook.com // Logan Moorehttps://comicbook.com/gaming/news/silent-hill-ps5-hideo-kojima-report-debunked/Follow us on Twitter @HitboxPod or send us an email at HitboxOfficialPodcast@gmail.com and let us know what you think!https://www.takethis.org/mental-health-resources/@peterspittech and @JustinMatkovichThe intro and outro of Hitbox! is by The Socials, check out their work right here: https://www.fiverr.com/thesocials?source=order
Red onion effective at killing cancer cells, study says University of Guelph (Ontario) If you're looking for a flavorful way to help fight and prevent cancer, add red onion to your shopping list. It will be worth the effort … as you will soon see why. In the first study of its kind, University of Guelph researchers looked at how the Ontario-grown red onion and several others affected the growth and proliferation of cancer cells. Their findings indicate that all onions are not created equal. The Canadian researchers looked at five different kinds of onion in total from the province of Ontario. They assessed the onions in terms of their effects against cancer cells and their ability to prevent cancer. Of the five species tested, the Ruby Ring red onion was the most effective. Few people are aware that onions are somewhat of a superfood. Hopefully, studies like these will help to change that. Onions in general have very high concentrations of the flavonoid quercetin. However, the Ruby Ring Ontario red onion has particularly high levels of these compounds as compared with other species. In the study, colon cancer cells were placed in direct contact with quercetin that was extracted from the five onion varieties studied. It was found that all of the onion types created an unfavorable environment for cancer cells and initiated cancer cell death, or apoptosis. Communication between the cancer cells seems to be disrupted by the compounds in the onions, and this can help to fight and prevent cancer. The study also showed that the Ruby Ring red onion was high in anthocyanin, a compound that helps to enrich the scavenging properties of quercetin. This in turn supports quercetin in fighting cancer cells and helping to prevent cancer. Anthocyanin is the molecule that gives vegetables like red onions their rich, deep color. This is in keeping with the general increased healthbenefits that can be gained from other dark or brightly colored vegetables and fruits. The recent onion study results were published in the journal Food Research International. While all of the onions studied showed the ability to inhibit cancer cells, red onions were particularly effective. Their beneficial compounds blocked the production of both colon cancer cells and breast cancer cells within the controlled conditions of the study. The next step is to complete human trials to further explore the cancer fighting effects of onions. Researchers are also working on an extraction technique to isolate the quercetin in onions so that it can be administered as a cancer therapy. In the meantime, finding ways to include more of this cancer-fighting superfood into your diet can allow you to experience many health benefits. Enjoy red onions in salads, on sandwiches and cooked into soups, stews and stir-fry dishes. Age and aging have critical effects on the gut microbiome Cedars-Sinai Medical Center, October 4, 2021 Researchers at Cedars-Sinai have found that aging produces significant changes in the microbiome of the human small intestine distinct from those caused by medications or illness burden. The findings have been published in the journal Cell Reports. "By teasing out the microbial changes that occur in the small bowel with age, medication use and diseases, we hope to identify unique components of the microbial community to target for therapeutics and interventions that could promote healthy aging," said Ruchi Mathur, MD, the study's principal investigator. Research exploring the gut microbiome, and its impact on health, has relied predominantly on fecal samples, which do not represent the entire gut, according to Mathur. In their study, investigators from Cedars-Sinai's Medically Associated Science and Technology (MAST) Program analyzed samples from the small intestine–which is over 20 feet in length and has the surface area of a tennis court–for examination of the microbiome and its relationship with aging. "This study is the first of its kind to examine the microbial composition of the small intestine of subjects 18 years of age to 80. We now know that certain microbial populations are influenced more by medications, while others are more affected by certain diseases. We have identified specific microbes that appear to be only influenced by the chronological age of the person," said Mathur, an endocrinologist and director of the Diabetes Outpatient Treatment & Education Center. The 21st century has been referred to as the "era of the gut microbiome" as scientists turn considerable attention to the role trillions of gut bacteria, fungi and viruses may play in human health and disease. The microbiome is the name given to the genes that live in these cells. Studies have suggested that disturbances in the constellations of the microbial universe may lead to critical illnesses, including gastroenterological diseases, diabetes, obesity, and some neurological disorders. While researchers know that microbial diversity in stool decreases with age, Cedars-Sinai investigators identified bacteria in the small bowel they refer to as "disruptors" that increase and could be troublesome. "Coliforms are normal residents of the intestine. We found that when these rod-shaped microbes become too abundant in the small bowel–as they do as we get older–they exert a negative influence on the rest of the microbial population. They are like weeds in a garden," said study co-author Gabriela Leite, Ph.D. Investigators also found that as people age, the bacteria in the small intestine change from microbes that prefer oxygen to those that can survive with less oxygen, something they hope to understand as the research continues. "Our goal is to identify and fingerprint the small intestinal microbial patterns of human health and disease. Given the important role the small bowel plays in absorption of nutrients, changes in the microbiome in this location of the gut may have a greater impact on human health, and warrants further study," said Mark Pimentel, MD, director of the MAST program and a co-author of the study. This research is part of Cedars-Sinai's ongoing REIMAGINE study: Revealing the Entire Intestinal Microbiota and its Associations with the Genetic, Immunologic, and Neuroendocrine Ecosystem. Study finds no association between caffeine intake and invasive breast cancer risk University of Buffalo, September 28, 2021 Researchers from the University at Buffalo conducted a study of nearly 80,000 postmenopausal women in the U.S. to determine whether caffeine consumption from coffee and tea has any association with invasive breast cancer. The average age when U.S. women reach menopause, 51, also happens to coincide with the age group—50- to 64-year-olds—that has the highest reported caffeine consumption. In addition to that, the average age of breast cancer diagnosis in the U.S. is 62. This overlap of age at menopause, age at diagnosis of breast cancer and age with high caffeine consumption gave greater weight to the importance of clarifying whether caffeine intake impacts breast cancer risk in postmenopausal women. It does not, according to the UB researchers' findings, published in August in the International Journal of Cancer. "From our literature review, many studies have found significant associations between coffee and/or tea consumption and reduced breast cancer incidence whereas a few studies have reported elevated risk. Our study, however, found no association," said study first author Christina KH Zheng, who worked on the study while completing her master's in epidemiology at UB. She is now a surgical resident in the MedStar Baltimore general surgery program. "About 85% of Americans drink at least one caffeinated beverage a day. It is important for the public to know whether consumption of caffeinated beverages has beneficial or harmful effects on breast cancer, the most common type of cancer and second-leading cause of cancer death for U.S. women," said Lina Mu, MD, Ph.D., the study's senior author, who is an associate professor of epidemiology and environmental health at UB. "The overlap of age at diagnosis of breast cancer and age with high consumption of caffeine, and the inconsistent findings from previous studies motivated us to study whether this lifestyle factor could affect breast cancer risk in postmenopausal women," said Kexin Zhu, a study co-first author and epidemiology Ph.D. student in UB's School of Public Health and Health Professions. Researchers looked at a sample of 79,871 participants in the Women's Health Initiative Observational Study. Participants have for decades now completed yearly health questionnaires that help researchers learn more about diet and exercise habits, as well as disease, and any possible linkages. After a median follow-up of 16 years, there were 4,719 cases of invasive breast cancer identified. At first glance, women who reported drinking two to three cups of caffeinated coffee per day had a 12% higher risk of invasive breast cancer compared to non-drinkers. But that association was not statistically significant after adjusting for lifestyle factors, such as smoking and alcohol consumption. "Seeing null results after adjusting for lifestyle, demographic and reproductive factors informs us of the complexity that is the relationship between caffeine intake and invasive breast cancer risk," Zheng said. "Some lifestyle factors, like drinking alcohol and physical activity, might be associated with both coffee intake and breast cancer risk," Zhu explained. "Therefore, they might confound the initial positive associations. After we took the lifestyle factors into account, the results suggested that regular coffee drinking might not have an impact on invasive breast cancer risk." The risk of invasive breast cancer was even higher—22%—for women who reported drinking two to three cups of decaffeinated coffee each day. It was slightly lower when adjusted for lifestyle variables (smoking history, alcohol consumption, physical activity, etc.), and the association was not statistically significant when further accounting for reproductive variables such as family history of breast cancer and number of children The researchers were unable to determine if the elevated risk is due to the decaffeinated nature of the coffee, the amount consumed, or another factor unique to this population that was not accounted for in the study. The researchers did not observe a significant association between overall tea consumption and invasive breast cancer. Additional research needs to be done in order to understand whether different types of teas have different effects on breast cancer risk, Zhu said. Liver function improves with the consumption of Broccoli sprout extract Tokai University Tokyo Hospital (Japan), October 5, 2021 A Japanese study of broccoli sprouts and liver function has found the sulforaphane-rich food to be highly beneficial. An extract from broccoli sprouts given to male participants was shown to improve hepatic abnormalities and overall liver function significantly. For the study, the researchers conducted a double blind, randomized placebo-controlled trial of males with fatty liver disease. The subjects received either extract of broccoli sprouts in capsule form, or a placebo. The capsules contained glucoraphanin, a precursor for the sulforaphane in broccoli sprouts. A number of key liver function markers were measured before and after the trial. It was determined that dietary supplementation with extract of broccoli improved liver functioning by decreasing alkali phosphatase activity and oxidative stress markers. Broccoli sprout extract was also found to prevent NDMA-induced chronic liver failure in rats. The researchers believe the antioxidants in broccoli sprouts are effective in suppressing the mechanisms of liver failure at a cellular level. The reduction of oxidative stress is crucial in protecting the liver and improving its health, and broccoli is loaded with health-supporting antioxidants. Non-alcoholic fatty liver disease (NAFLD) is also reaching epidemic proportions, with nearly 30 percent of Americans (90 million people) having some level of the disease. Like hep C, NAFLD can result in liver failure and cancer of the liver in the most severe cases. Exposure to environmental toxins exacerbates liver conditions as well, with the glyphosate found in weed killers, like Roundup, particularly harmful. The good news is that liver conditions are preventable by embracing a healthy lifestyle. Eating plenty of organic fruits and vegetables, exercising regularly and avoiding alcohol and cigarettes can do wonders for liver health. As evidenced by the recent research out of Japan, sulforaphane-rich broccoli sprouts can be a key component in supporting healthy liver function. Milk thistle, vitamin E, black seed oil and dandelion root have also shown effectiveness in supporting and detoxifying the liver. How cannabis-like substances keep the brain in balance Utrecht University (Netherlands), October 4, 2021 Whenever we learn, remember or forget something, a surprisingly active role is played by cannabis-like substances in the brain. Researchers at Utrecht University found that the substances actively balance connections in the brain that allow cells to either activate or inhibit each other. The discovery reveals how brain cells influence each other, and how psychiatric disorders can arise when this process goes wrong. Although wisdom comes with age, our brain does not store every single experience or lesson learned. In addition to learning and remembering, our brains are also equipped to forget irrelevant things or drop unused skills. In order to find a balance in this, brain cellsconstantly communicate with each other through connections that activate or inhibit the cells. Researchers from Utrecht University discovered that brain cells can form new, inhibitory connections via so-called endocannabinoids. They reported their discovery in Journal of Neuroscience. Counterbalance Endocannabinoids derive their name from the cannabis plant, which contains similar substances. The researchers discovered the role of endocannabinoids when they induced brain cells of mice to strengthen activating connections. In response, the brain cells also started making new inhibitory connections. The researchers found that endocannabinoids kickstarted the new connections. Surprisingly active role The researchers were surprised to find that these substances play such an active role. "Nobody expected this from endocannabinoids," says research leader Dr. Corette Wierenga, neurobiologist at Utrecht University. It was already known that endocannabinoids can influence the functioning of our brains. But until now researchers assumed that the substances were merely involved in adjusting existing connections. "Now it appears that the system of endocannabinoids can actively push the production of new inhibitory connections, with which brain cells actively regulate the balance." Psychiatric disorders caused by imbalance The discovery could help scientists to better understand how psychiatric disordersand other abnormalities in the brain develop. In many of these disorders, the balance between inhibitory and activating connections is disturbed. During an epileptic seizure, for example, this balance is seriously disturbed. Although in many other disorders the disturbance is more subtle, for example in schizophrenia, the impact can still be equally profound. Cannabis-related unbalance The balance between activating and inhibiting connections in our brain is constantly being adjusted in response to our experiences. Whenever we experience something, the connections change, and the brain must restore the balance. Cannabis use can disrupt that balance. "Occasional cannabis use will not seriously disturb the balance," says Wierenga. "But if the balance is disturbed for a longer period, it can cause problems. For example, children of mothers who smoked marijuana during pregnancy can experience problems with neurological development." Early stages of life The balance is especially important in early stages of life, Wierenga says. "During our development, brain connections are constantly changing. Especially during that period, it is important that inhibitory and activating connections remain coordinated. If the coordination is malfunctioning or disturbed, you can imagine that the system becomes disrupted. And unfortunately, disruptions that occur so early cannot be easily repaired later in life." According to Wierenga, such disruptions can lead not only to loss of memory, but also initiate more serious consequences. For example, the brain might grow out to less adaptive to stressful situations. "When this happens, things get out of hand more easily in the brain, because inhibition and activation are out of balance. That could lead to learning and behavioral problems." Predicting and preventing disorders Creating a deeper understanding of the role endocannabinoids play in the brain, could lead to psychiatric disorders being more predictable or even prevented in the future. The publication in Journal of Neuroscience now sets out a new direction in which more knowledge can be built up. Wierenga: "Ultimately, as a researcher, we want to understand how brain cells coordinate the balance and what happens when that balance is disturbed. Glycerin is safe, effective in psoriasis model Medical College of Georgia at Augusta University, October 4, 2021 Patients with psoriasis have reported that glycerin, an inexpensive, harmless, slightly sweet liquid high on the list of ingredients in many skin lotions, is effective at combatting their psoriasis and now scientists have objective evidence to support their reports. They found that whether applied topically or ingested in drinking water, glycerin, or glycerol, helps calm the classic scaly, red, raised and itchy patches in their psoriasismodel, Dr. Wendy Bollag, cell physiologist and skin researcher at the Medical College of Georgia and Charlie Norwood VA Medical Center and her colleagues report in the International Journal of Molecular Sciences. The studies also provide more evidence of the different ways glycerin enables the healthy maturation of skin cells through four stages that result in a smooth, protective skin layer. Psoriasis is an immune-mediated problem that typically surfaces in young adults in which skin cells instead multiply rapidly, piling up into inflamed patches. "We have experimental data now to show what these patients with psoriasis are reporting," says Bollag, who nearly 20 years ago first reported in The Journal of Investigative Dermatology that glycerin, a natural alcohol and water attractor known to help the skin look better, also safely helped it function better by helping skin cells mature properly. Bollag's early report led to many anecdotal reports from individuals and their reports ultimately led to the newly published study. Topically, glycerin is known to have a soothing, emollient effect. But another key part of its magic, which Dr. Bollag has helped delineate, is its conversion to the lipid, or fat, phosphatidylglycerol, which ultimately regulates the function of keratinocytes, our major skin cell type, and suppresses inflammation in the skin. Glycerin gets into the skin through avenues like aquaporin-3, a channel expressed in skin cells, and the MCG scientists have shown that once inside, aquaporin 3 funnels glycerin to phospholipase-D-2, an enzyme that converts fats in the external cell membrane into cell signals, ultimately converting glycerin to phosphatidylglycerol. In 2018, Bollag and team reported that topical application of phosphatidylglycerol reduced inflammation and the characteristic raised skin patches in a mouse model of psoriasis. This time they decided to look at the impact of its widely available precursor glycerin. For the new studies, they used imiquimod, which is known to produce psoriasis-like plaques on humans using it for problems like genital warts and some skin cancers, to produce an animal model. The mice either drank the sweet natural alcohol or the scientists applied it topically. Either way, glycerin helped reduce development of the characteristic skin lesions, the scientists report, a finding which helps underline that glycerin works in more than one way to improve the skin condition. Externally, glycerin showed its action as an emollient because even in mice missing phospholipase-D-2, it was beneficial. Additionally, topically it appears to compete with hydrogen peroxide for space inside the aquaporin 3 channel. Hydrogen peroxide is commonly known as a mild antiseptic but we produce it as well and at low levels it's a cell signaling molecule. But at high levels, hydrogen peroxide produces destructive oxidative stress, which can actually cause psoriasis. The scientists found that topical glycerin reduced the levels of hydrogen peroxide entering skin cells. When they added glycerin and hydrogen peroxide at the same time directly to skin cells, they found that glycerin protected against the oxidative stress from hydrogen peroxide. "Glycerol is basically outcompeting the hydrogen peroxide in getting in there and preventing it from being able to enter and increase oxidative stress," Bollag says. Oil and water don't mix, so yet another way glycerin may be helpful is by supporting the skin's major role as a water permeability barrier so that, as an extreme, when we sit in a bathtub the bath water doesn't pass through our skin so we blow up like a balloon, she says. On the other hand, when glycerin was ingested by the mice missing the phospholipase- D-2, which converts fats or lipids in a cell's membrane to signals, it simply did not work, Bollag says, which confirmed their earlier findings that internally anyway, glycerin pairs with the enzyme to produce the signal essential to skin cell maturation. Some of their other most recent work is detailing more about how phosphatidylglycerol decreases inflammation. Bollag would like next steps to also include clinical trials with dermatologists and patients and is working to find a formulation scientist who can make what she thinks will be the optimal combination: glycerin and phosphatidylglycerol in the same topical cream. The addition of phosphatidylglyerol itself, rather than just the glycerin that makes it, is essentially a backup since there is some evidence that in psoriasis the essential conversion of glycerin to phosphatidylglycerol is not optimal. Bollag's lab and others have shown reduced levels of aquaporin 3 in psoriasis, which likely means less phosphatidylgycerol, so making more glycerin available may help, albeit not as efficiently, raise the availability of this lipid essential to normal skin cell proliferation. Moving quickly into clinical trials should be comparatively easy since, as with glycerin, there already is experience with the use of phosphatidylglycerol in humans. For example, it's a component of some high-end cosmetics, Bollag says. She suspects that this sort of two-punch combination, could help keep early signs of psoriasis at bay and, with more advanced disease, use existing psoriasis treatments to get the skin condition under control then start applying glycerin to help keep it that way. Bollag and her colleagues reported in 2018 in the Journal of Investigative Dermatology that in a mouse model of psoriasis, phosphtidylglycerol reduced inflammation and the characteristic raised skin lesions of psoriasis. While its exact cause is unclear, psoriasis is an immune-mediated condition and patients have higher levels of inflammation, as well as too many skin cells being produced then maturing abnormally. The heightened inflammation also puts them at increased risk for problems like heart disease. Biologics used to treat psoriasis work different ways to stem this overactive immune response but in addition to their high cost, can put the patient at risk for problems like serious infections and cancer. The only side effect she has seen in about 20 years of working with glycerin and the clinical and cosmetic use already out there, is it can leave the skin feeling slightly sticky. Our bodies can make glycerol from the carbohydrates, proteins and fats that we eat or already have in our body.
This summer, many parts of the world have seen devastating flooding, from New Orleans and New York, to the UK, Germany and Belgium. More than 300 people lost their lives in floods in central China, including a number who were trapped in a subway train in the city of Zhengzhou. Professor Hannah Cloke of the University of Reading is a natural hazards researcher and hydrologist, who spends her time trying to prevent these terrible losses. She models where flooding is likely to happen and advises governments. Hannah Cloke talks to Jim al-Khalili about how her fascination with the water on the earth goes back to her childhood – her memories of holidays for instance all revolve around swimming or building dams on the beach. She is now passionate about finding new ways of telling the public about the dangers of flooding, which includes writing poetry.
PWTorch editor Wade Keller presents an Interview Classic from five years ago (9-29-2016) with Kevin Eck, former WWE creative team member from 2011-2014 and also a long-time journalist who currently writes a popular blog on pro wrestling. Keller begins with an update on TNA's ownership situation with developments ongoing during the show, then gets insights from Kevin on how WWE management is likely to evaluate TNA wrestlers should WWE acquire TNA or that talent become available to sign, including Bobby Lashley, EC3, Drew Galloway, Gail Kim, and Abyss. Also, in-depth discussions on the Cruiserweight Division, Dolph Ziggler, A.J. Styles, Seth Rollins, and Roman Reigns.
The Huddle talks Jordan Poole, Media Day, and the 21-22 season with SF Chronicle's Rusty Simmons SUPPORT US ON PATREON by clicking here: Huddle Patreon GET A HUDDLE T-SHIRT & MORE click here: Huddle Merch LEAVE US A VOICEMAIL: 510-473-5133 TWEET US by clicking here: warriorshuddle EMAIL US by clicking here: email@example.com Subscribe to us on Apple Podcasts here, Spotify or Stitcher here. Support the show: https://www.patreon.com/warriorshuddle?utm_medium=social&utm_source=twitter&utm_campaign=creatorshare2 See omnystudio.com/listener for privacy information.
Sisters Katelyn and Sierra Laird (actor-writer-producers with a film and theatre production company) join to talk about the truly wild time they had on set that included ghosts, a trip to the ER, a pajama clad doctor, and more! Shannon tells the tale of the Bean-nighe, a Scottish hag who is commonly topless and predicts the death of those who happen upon her.
On today's Locked On Auburn, Zac Blackerby is joined by Matt Moscona of Locked On LSU for a crossover show. The guys talk about Auburn football vs LSU and what fans should expect going into Saturday. Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices
One of my closest friends, Adam Taylor, joins the show for a more relaxed episode focused on our predictions for the 2021-22 NBA Awards. Most Valuable Player, Defensive Player of the Year, Coach of the Year, Rookie of the Year, Most Improved Player, and Sixth Man of the Year. We each share our top three for each possible award, along with one sleeper candidate to consider. Learn more about your ad choices. Visit podcastchoices.com/adchoices
With training camp underway the attention turns to the rotation for the start of the season. Kane mapped out his rotation for opening night and Justin joins him to break it all down.Support Us By Supporting Our Sponsors!SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Indeed Get started RIGHT NOW with a SEVENTY-FIVE DOLLAR SPONSORED JOB CREDIT to upgrade your job post at Indeed.com/locked Learn more about your ad choices. Visit podcastchoices.com/adchoices
We discuss a tough loss for the Yankees in Toronto, before talking about what it'll take to win the rubber match of the series Thursday against Robbie Ray. Then we make predictions about which two teams will emerge to compete in the AL wild-card. Hosts: CC Sabathia and Ryan Ruocco Producers: Bobby Wagner and Sadye Zillo Learn more about your ad choices. Visit podcastchoices.com/adchoices
Michael Simione (@SPStreamer) and Lauren Auerbach (@LKAuerbach) discuss what we think the first round of 2022 could look like. We also relate it to an early mock that was done by some industry analysts!Subscribe to:Youtube: https://www.youtube.com/channel/UCiVFvV-7zqqXutsdAmtw8jQTwitch: https://www.twitch.tv/spstreamer
5.30 tracks the evolving MLB playoff picture (0:39), kicks around some EPL (2:46), schemes the last TGFBI push (4:40), reads through the abstract for “Predicting draft opponents' behavior with agent-based modeling” (14:43), and reviews David Fletcher (20:12).
The USMNT return to World Cup Qualifying in just over a week and the guys run through their picks for the 26 man roster. The most pressing question remains, will Weston McKennie rejoin the team this window? The guys listen to excerpts from Gregg Berhalter's podcast to get some insight. Does the USMNT need to add some more veteran presence to the team to make sure similar mistakes don't happen again? Is it time for Julian Green to return!? Finally, MLS & Liga MX announced the New Leagues Cup format launching in 2023 and let's just say... the guys are divided. Support The Best Soccer Show on Patreon: https://bit.ly/360mTM6
Here's how you can find Matt: Youtube: https://www.youtube.com/channel/UChxbDRocu-La__8XWdgPrqwEbay: https://ebay.com/usr/ferraratronInstagram: https://www.instagram.com/ferraratron_pokemon/Trade/Sales References: https://www.instagram.com/p/B9cl4tsFSTQ/?igshid=ks8uofxn8bjsHere's how you can find Tom: Instagram: https://www.instagram.com/pancake_analytics/Pokemon Data Science Book: https://www.amazon.com/dp/B08ZQ3NVLX/ref=sr_1_2?dchild=1&keywords=pokemon+data+science&qid=1616522638&sr=8-2Ebay: https://ebay.com/usr/pancake_analyticsYoutube: https://www.youtube.com/channel/UCk3mHuN3TwfFTHsJRcsHfzg?view_as=subscriberFacebook: https://www.facebook.com/pancakeanalytics/?ref=bookmarksComic Con Data Science Blog: https://pancakebreakfaststats.com/Get on the waiting list for early access to CardFolio!You can find me here:IG:@geeked_out_collectingTwitch:/feliwankenobiWebsite:www.GeekedOutCollecting.comFree Profit Calculator for eBay: www.profitcalculator.online/profitCalculator.htmlFree BGS Calculator: www.profitcalculator.online/bgscalc.htmlPatreon: www.patreon.com/Geekedoutcollecting
-The guys discuss the Yankees lineup for tonight -Evan wants Aaron Boone to whip out the jumbo package -"Patrolling" center field -Predicting how many runs the Yankees and Red Sox will score -Craig's bad hand writing -Evan's standup from last night See omnystudio.com/listener for privacy information.
The Iowa Hawkeye athletic program made history with the announcement that they would be adding women's wrestling in 2023. We break down what all of that means and why Gary Barta is getting let off the hook easy but shouldn't be before diving into all of the storylines you need to know when Iowa takes on Colorado State tomorrow. How important is Jestin Jacobs? Will we see young guys like Arland Bruce IV and Keagan Johnson get more involved? How will the offensive line rotation continue to shake out with Connor Colby, Justin Britt, and Kyler Schott? We got you covered right here. Support Us By Supporting Our Sponsors! SweatBlock Get it today for 20% off at SweatBlock.com with promo code LockedOn, or at Amazon and CVS. Built Bar Built Bar is a protein bar that tastes like a candy bar. Go to builtbar.com and use promo code “LOCKED15,” and you'll get 15% off your next order. BetOnline AG There is only 1 place that has you covered and 1 place we trust. Betonline.ag! Sign up today for a free account at betonline.ag and use that promocode: LOCKEDON for your 50% welcome bonus. Rock Auto Amazing selection. Reliably low prices. All the parts your car will ever need. Visit RockAuto.com and tell them Locked On sent you. Learn more about your ad choices. Visit podcastchoices.com/adchoices
The 2022 NBA standings will look nothing like last year. We saw so many injuries to bigname players and had games packed together which caused teams to load manage stars. The league is finally back to a normal schedule and fans of underdog teams are in for a shock.
Adam is joined by a super special guest to look at the keys and predict the result for the Huskers vs Michigan State. Support the show: https://www.omaha.com/ See omnystudio.com/listener for privacy information.
Mac and Bone discuss the chances of a Panthers letdown in primetime tonight, predict what some of the storylines will be around the Panthers after tonight's game and learn a little bit more about the Texans with the help of John McClain. See omnystudio.com/listener for privacy information.
College Wrestling Preseason is here! And we're diving into everything happening in the Big Ten this season. Who's #1? When are the best duals? And who will give Spencer Lee the best match? Show Topics: Power Ranking the Big Ten Teams Top 5 Big Ten Duals to Watch in 2022 Previewing the Entire Big Ten Dual Season Who's Standing in Spencer Lee's Way at 125lbs? ———————————— ⭐ Did you enjoy this week's college wrestling news updates? Consider writing a review to help The Fanco Wrestling Show grow! https://bit.ly/FancoWrestlingShow
Dr. Eric Eager, Vice President of Research and Development at PFF, joins the show to talk about football analytics. Eric talks about early insights from the player grades that PFF creates by watching every play of every game. He also describes two of his recent studies: how offensive line continuity affects the point spread and how to better predict sacks and interceptions. Eric also discusses whether rushing actually matters in the NFL and the betting value on two week 3 NFL games.
Which Street Fighter games have the best music? I went back and listened to a ton of OSTs to order the numbered SF entries from least to most inspired/inspiring themes. Catalyst, on the other hand, spent hours researching Street Fighter lore to explore some of the most interesting potential directions Capcom could take with Street Fighter 6's story.
There are some massive games happening all across the midwest and the rest of the nation this weekend. One of the biggest is the annual Whiteout game at Penn State where the Nittany Lions will welcome in Auburn. That's a game you could hear a lot about this fall... depending on how it goes. Buckeye Scoop's Tony Gerdeman and Tom Orr preview that and some of the other big games this weekend. - Will Luke Fickell and Cincinnati move one step closer to an improbable College Football Playoff berth?- Will Notre Dame have to survive a third-straight scare?- Can Emory Jones keep Florida close with Alabama? - Will Michigan State pull an upset against Miami?- Is Nebraska going to wish they really did cancel this weekend's game against Oklahoma?
After covering the Milwaukee Bucks own Central Division last week, Rohan Katti and Ti Windisch decided to take a look at the rest of the East this time around, and went through the Atlantic and Southeast Divisions team by team, giving their thoughts on their offseason progress (or lack thereof) and projecting their 2021-22 win totals. Basically these teams are the Brooklyn Nets plus a bunch of teams clearly worse than the Bucks. Get the earliest heads up on ALL GSPN content, including podcasts, YouTube videos, and even new written articles on the GSPN Substack! The Gyro Step Podcast Network is on YouTube for live podcasts and other projects including this very podcast episode and many more to come, subscribe today! GSPN is proud to call Blue Wire's network of podcasts home. You can (and should) follow Rohan, Ti, Adam, Jordan, and the Gyro Step and the Win In 6 podcast on Twitter. Learn more about your ad choices. Visit podcastchoices.com/adchoices
95.7 The Game's Butcher Boy joins the Huddle for the first time, predicts what Steph might do next year, and drops knowledge on how Moses Moody will impact Golden State. SUPPORT US ON PATREON by clicking here: Huddle Patreon GET A HUDDLE T-SHIRT & MORE click here: Huddle Merch LEAVE US A VOICEMAIL: 510-473-5133 TWEET US by clicking here: warriorshuddle EMAIL US by clicking here: firstname.lastname@example.org Subscribe to us on Apple Podcasts here, Spotify or Stitcher here. Support the show: https://www.patreon.com/warriorshuddle?utm_medium=social&utm_source=twitter&utm_campaign=creatorshare2 See omnystudio.com/listener for privacy information.
John and Tim give their predictions for Team Canada and make some key observations about this group of players. Who are the odd men out on the front end? Is defense their weak point? Who gets the nod in net - Price or Fleury? Follow: @dropping_gloves Subscribe: youtube.com/johnscotthockey Merch: https://violentgentlemen.com/products/dropping-the-gloves-tee Violent Gentlemen Dropping the Gloves Tee Live the Hockey lifestyle with the Dropping the Gloves Tee from our Men's T-Shirts collection! More available at violentgentlemen.com!
Check out our sponsors: Indeed: Get a FREE $75 CREDIT to upgrade your job post at indeed.com/IMPACT Athletic Greens: Go to athleticgreens.com/impact and receive a FREE 1 year supply of Vitamin D AND 5 free travel packs with your first purchase! ConversionFanatics: Go to ConversionFanatics.com for a FREE proposal. Blinkist: Go to https://blinkist.com/impact Try it FREE for 7 days and save 25% off your new subscription. Tommy John: Get 20% OFF your FIRST ORDER at tommyjohn.com/impact Justworks: justworks.com Bitcoin, cryptocurrency, blockchain, and NFTs, when does it all stop and go away? Good news, chances are it never will. Bad news, chances are it's not going away and if you've been avoiding this conversation, it needs to end today. Cryptocurrency is the fastest growing technology we've ever witnessed in human history. 10 years ago people doubted it, laughed at it, and blew it off. Today, countries like Nigeria, Vietnam and the Philippines are starting to adopt crypto. What is often rejected and feared is typically not understood. While billionaires and master investors once turned their backs to Bitcoin and the crypto world, they are slowly coming around and see the potential of what this currency and technology really is. Anthony Pompliano joins Tom to put you on notice and help you better understand exactly why low income and middle class people literally cannot afford to continue dismissing the potential for building wealth with cryptocurrency. Blockchain is happening and there is a major shift in wealth and purchasing power taking place. You owe it to yourself and to your future generations to at least do some more research, investigate and find out how you can better leverage the potential that a new digital world represents for you. The cost of entry is low, it's decentralized, and for the first time you are not restricted by your income to take advantage. SHOW NOTES: 0:00 | Introduction Anthony Pompliano 0:50 | Disadvantage of Non-Investors 7:27 | Understanding Personal Finance 13:18 | Cryptocurrency and Fiat Money 20:44 | Bitcoin's Volatility Advantages 25:36 | Breadcrumbs for Going Digital 30:50 | Increasing Purchasing Power 35:22 | Censored Payment Systems 46:15 | Benefit of Open Payment System 56:23 | Decentralized Tech Structure 1:03:00 | Predicting vs. Observing Market 1:09:45 | Digital Versions of Analog (NFTs) 1:20:05 | Blockchain Is Happening 1:31:13 | The Monetary Revolution 1:38:55 | Bitcoin Global Reserve Currency 1:47:04 | Why Pomp Choices Bitcoin QUOTES: “Poor people spend the middle class, save, and then the wealthy invest.” Tom Bilyeu [0:24] “There's really one key rule that everyone has to understand, which is, the dollars will be worth less than purchasing power terms over a long period of time.” [3:43] “It's easy to mock and make fun of these young people. But these young people are interested in understanding how does the market works.” [8:03] “It is impossible, literally impossible in America to get a financial security position by saving” [10:21] “I can either suffer at the hands of this system, or I can flip around to the other side table, and I can benefit from the system. Every single rich person understands how to benefit from the system, hold assets, not a currency” [18:46] “All money, at the end of the day, is a unit of time.” [31:28] “Bitcoin, specifically, it has a financial component that is unavailable and other assets, it is systematically built to continue to protect your purchasing power” [33:02] “The more that you can be a market observer, rather than a market predictor, you start to just understand, crazy stuff happens.” [1:07:03] “The digital version of something is always bigger than the analog version” [1:10:19] “Everything you think is cool is going to go to zero, and everything that you think is dumb is going to moon.” Tom Bilyeu [1:19:36] Follow Anthony Pompliano: Website: https://www.anthonypompliano.com/ YouTube: https://www.youtube.com/channel/UCevXpeL8cNyAnww-NqJ4m2w Twitter: https://twitter.com/APompliano
Tonight's guests are Jamal Greene, Columbia Law School Dwight Professor of Law; Idaho State Rep. Ilana Rubel; and Michael Beschloss, NBC News presidential historian and host of Fireside History with Michael Beschloss.
We're kicking off our weekly Friday Fun here on the Athletic Football Show with our first Mini-Contest of the year as Sheil Kapadia and Nate Tice go head-to-head in a winner-take-all battle for the ages. Who will come out on top in the picks game at the end of the season? Place your bets now! Plus the guys predict MVP, Super Bowl winners, Coach of the Year and more as week 1 finally arrives. Learn more about your ad choices. Visit megaphone.fm/adchoices
Brandon Lee Gowton and RJ Ochoa shared their predictions for the Eagles, Cowboys, Giants and Washington Football team this season! Learn more about your ad choices. Visit podcastchoices.com/adchoices