Podcasts about Encode

This week, Emily Bazelon, John Dickerson, and David Plotz discuss why Republicans are holding an unusual midterm convention and what it says about the state of the race at the homestretch, talk about the new book Profiles in Cowardice: A Study of Collaboration in the Trump Era with author Jacob Weisberg, and reflect on memories and historical consequences on the 25th anniversary of the 9/11 terror attack. Here are this week's chatters: Emily: Hansi Lo Wang for NPR: Trump officials propose sweeping changes to the census that would reshape voting maps; Data Are Made, Not Found: A Story of Politics, Power, and the Civil Servants Who Saved the US Census by danah boyd; Charity and Sylvia by Tillie Walden John: Associated Press: US Attorney confirms no meth was found in van of Texas man shot by immigration officers; Kristen Wong for Sports Illustrated: At His Highest Moment, Frances Tiafoe Rose Even Higher. His Viral U.S. Open Hug Is Why We Love Sports. David: Colossus: The Forbin Project (1970) - Official Trailer (HD) (2:56 long on YouTube) Listener chatter from Adam Forkner in Boston, Massachusetts: Dave Epstein for The Boston Globe: What my Maine dock taught me about the threat of invasive marine life looming in the Persian Gulf; Tamburri, M.N., Carlton, J.T., Blakeslee, A.M.H. et al. Closure of the Strait of Hormuz may trigger a bioinvasion super-spreader event. Biol Invasions 28, 177 (2026). For this week's Slate Plus bonus episode, Emily, John, and David discuss this week's big AI story, a researcher's resignation from Anthropic and his dire warnings about AI's imminent dangers to humanity, with guest Nathan Calvin, general counsel at Encode. They discuss the exponential pace of AI development, what the big companies are or are not doing to protect humans from apocalypse, and the simultaneous governmental and industry cooperation that could help manage risks. In the latest Gabfest Reads, David Plotz talks with John Lanchester about his new novel, Look What You Made Me Do, a darkly funny psychological thriller about two couples in modern-day London whose lives collide in a story of infidelity, obsession, and revenge. The book explores the performance of niceness, class, intergenerational frictions and how technology makes vengeance not just possible but almost exceedingly easy in the modern age. Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.)Podcast production by Nina Porzucki Research by Emily DittoYou can find the full Political Gabfest show pages here. Want more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you'll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. Find out more about David Plotz's monthly tours of Ft. DeRussy, the secret Civil War fort hidden in Rock Creek Park. Follow@SlateGabfest on X / https://twitter.com/SlateGabfestSlate Political Gabfest on Facebook / https://www.facebook.com/Gabfest/Need to set up your Slate Plus feed? If you subscribed through Slate.com, check out our FAQ at slate.com/podcastfaqs for easy instructions. Members subscribed via Apple Podcasts get automatic access—no setup required. Hosted on Acast. See acast.com/privacy for more information.

This week, Emily Bazelon, John Dickerson, and David Plotz discuss why Republicans are holding an unusual midterm convention and what it says about the state of the race at the homestretch, talk about the new book Profiles in Cowardice: A Study of Collaboration in the Trump Era with author Jacob Weisberg, and reflect on memories and historical consequences on the 25th anniversary of the 9/11 terror attack. Here are this week's chatters: Emily: Hansi Lo Wang for NPR: Trump officials propose sweeping changes to the census that would reshape voting maps; Data Are Made, Not Found: A Story of Politics, Power, and the Civil Servants Who Saved the US Census by danah boyd; Charity and Sylvia by Tillie Walden John: Associated Press: US Attorney confirms no meth was found in van of Texas man shot by immigration officers; Kristen Wong for Sports Illustrated: At His Highest Moment, Frances Tiafoe Rose Even Higher. His Viral U.S. Open Hug Is Why We Love Sports. David: Colossus: The Forbin Project (1970) - Official Trailer (HD) (2:56 long on YouTube) Listener chatter from Adam Forkner in Boston, Massachusetts: Dave Epstein for The Boston Globe: What my Maine dock taught me about the threat of invasive marine life looming in the Persian Gulf; Tamburri, M.N., Carlton, J.T., Blakeslee, A.M.H. et al. Closure of the Strait of Hormuz may trigger a bioinvasion super-spreader event. Biol Invasions 28, 177 (2026). For this week's Slate Plus bonus episode, Emily, John, and David discuss this week's big AI story, a researcher's resignation from Anthropic and his dire warnings about AI's imminent dangers to humanity, with guest Nathan Calvin, general counsel at Encode. They discuss the exponential pace of AI development, what the big companies are or are not doing to protect humans from apocalypse, and the simultaneous governmental and industry cooperation that could help manage risks. In the latest Gabfest Reads, David Plotz talks with John Lanchester about his new novel, Look What You Made Me Do, a darkly funny psychological thriller about two couples in modern-day London whose lives collide in a story of infidelity, obsession, and revenge. The book explores the performance of niceness, class, intergenerational frictions and how technology makes vengeance not just possible but almost exceedingly easy in the modern age. Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.)Podcast production by Nina Porzucki Research by Emily DittoYou can find the full Political Gabfest show pages here. Want more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you'll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. Find out more about David Plotz's monthly tours of Ft. DeRussy, the secret Civil War fort hidden in Rock Creek Park. Follow@SlateGabfest on X / https://twitter.com/SlateGabfestSlate Political Gabfest on Facebook / https://www.facebook.com/Gabfest/ Hosted on Acast. See acast.com/privacy for more information.

This week, Emily Bazelon, John Dickerson, and David Plotz discuss why Republicans are holding an unusual midterm convention and what it says about the state of the race at the homestretch, talk about the new book Profiles in Cowardice: A Study of Collaboration in the Trump Era with author Jacob Weisberg, and reflect on memories and historical consequences on the 25th anniversary of the 9/11 terror attack. Here are this week's chatters: Emily: Hansi Lo Wang for NPR: Trump officials propose sweeping changes to the census that would reshape voting maps; Data Are Made, Not Found: A Story of Politics, Power, and the Civil Servants Who Saved the US Census by danah boyd; Charity and Sylvia by Tillie Walden John: Associated Press: US Attorney confirms no meth was found in van of Texas man shot by immigration officers; Kristen Wong for Sports Illustrated: At His Highest Moment, Frances Tiafoe Rose Even Higher. His Viral U.S. Open Hug Is Why We Love Sports. David: Colossus: The Forbin Project (1970) - Official Trailer (HD) (2:56 long on YouTube) Listener chatter from Adam Forkner in Boston, Massachusetts: Dave Epstein for The Boston Globe: What my Maine dock taught me about the threat of invasive marine life looming in the Persian Gulf; Tamburri, M.N., Carlton, J.T., Blakeslee, A.M.H. et al. Closure of the Strait of Hormuz may trigger a bioinvasion super-spreader event. Biol Invasions 28, 177 (2026). For this week's Slate Plus bonus episode, Emily, John, and David discuss this week's big AI story, a researcher's resignation from Anthropic and his dire warnings about AI's imminent dangers to humanity, with guest Nathan Calvin, general counsel at Encode. They discuss the exponential pace of AI development, what the big companies are or are not doing to protect humans from apocalypse, and the simultaneous governmental and industry cooperation that could help manage risks. In the latest Gabfest Reads, David Plotz talks with John Lanchester about his new novel, Look What You Made Me Do, a darkly funny psychological thriller about two couples in modern-day London whose lives collide in a story of infidelity, obsession, and revenge. The book explores the performance of niceness, class, intergenerational frictions and how technology makes vengeance not just possible but almost exceedingly easy in the modern age. Email your chatters, questions, and comments to gabfest@slate.com. (Messages may be referenced by name unless the writer stipulates otherwise.)Podcast production by Nina Porzucki Research by Emily DittoYou can find the full Political Gabfest show pages here. Want more Political Gabfest? Join Slate Plus to unlock weekly bonus episodes. Plus, you'll access ad-free listening across all your favorite Slate podcasts. You can subscribe directly from the Political Gabfest show page on Apple Podcasts and Spotify. Or visit slate.com/gabfestplus to get access wherever you listen. Find out more about David Plotz's monthly tours of Ft. DeRussy, the secret Civil War fort hidden in Rock Creek Park. Follow@SlateGabfest on X / https://twitter.com/SlateGabfestSlate Political Gabfest on Facebook / https://www.facebook.com/Gabfest/ Hosted on Acast. See acast.com/privacy for more information.

Episode 406 explains how movement prepares the brain but does not guarantee learning. It traces the full sequence—movement, RAS-driven readiness, salience and relevance, focused attention, encoding, retrieval and repetition, and recovery and sleep—that turns activation into lasting memory and performance. The episode offers practical steps in a Move–Focus–Learn protocol: use brief movement to create readiness, clearly identify and remove distractions for one learning target, interact with material in meaningful ways, practice retrieval and spaced repetition, and protect recovery to support consolidation. Listeners are encouraged to test these simple experiments for school, work, or personal learning to make experience more usable and improve attention, memory, and performance. ON THIS EPISODE, YOU'LL LEARN: ✔ Why movement prepares the brain but does not guarantee learning ✔ How attention directs the capacity movement creates ✔ Why meaning and emotional relevance capture attention ✔ The difference between paying attention and actually learning ✔ How retrieval and repetition help new information stick ✔ How seeing, hearing, explaining, and applying an idea can help us remember it ✔ How restorative sleep supports memory and learning ✔ A practical Move–Focus–Learn Protocol for school, work, or your own personal learning The central idea is simple: Movement opens the window. Attention determines what enters. Repetition strengthens what remains. And recovery helps the brain integrate what it has experienced. Welcome back to the Neuroscience Meets Social and Emotional Learning Podcast, where we bridge neuroscience, social and emotional learning, and human performance so we can create measurable improvements in our well-being, achievement, leadership, productivity, and results. I'm Andrea Samadi, and if you've been following along through Season 16, you'll know that we have been building what I call The Brain's Operating System for Human Performance—a neuroscience-based framework designed to help us understand how the different systems of the brain and body work together to influence how we learn, adapt, connect, lead, and ultimately, how we perform. We are currently in Phase 3, focused on Movement, Learning, and Cognition. As I prepared for this phase, I went back through more than 400 episodes of the podcast and organized them according to the five phases of this framework. I wanted to see whether any patterns would emerge. And some did. Phase 1, Regulation and Safety, includes 57 episodes. Phase 2, Neurochemistry and Motivation, includes 41 episodes—the smallest category, possibly because this is the area I have explored the least with my learning. Phase 3, Movement, Learning, and Cognition, includes 174 episodes—the largest category by far. Phase 4, Perception and Social Intelligence, includes 68 episodes. And Phase 5, Integration and Meaning, includes 71 episodes. When I saw that 174 episodes—more than 40 percent of the entire podcast—fit into Movement, Learning, and Cognition, it immediately showed me where much of my curiosity has been directed over the years. I have always been fascinated by learning: How do we prepare the brain to learn? What captures our attention? Why do some ideas (or people) remain with us while others disappear? How does knowledge become something we can retrieve, apply, and actually use to improve our lives? And while I am spending most of my spare time hiking, or at the gym over the years, I wonder, how does this movement that I'm doing help to improve my attention, or memory, and finally, where does recovery fit into this process? The past few weeks, I'm finally connecting the dots with how important recovery is with this equation. I'm also learning how to determine what's important to me. John Medina's Brain Rules book explains what holds our attention. He reminds us that “we don't pay attention to boring things (or people).[i] As we continue through these five phases of The Brain's Operating System for Human Performance, I'm especially curious about how we will move beyond understanding these lessons, to begin implementing what we are learning, and connecting more ways to improve how we learn, adapt, connect, lead, and ultimately perform in our day to day lives. That will become an important part of the upcoming workbook—which is a practical way for each of us to identify what we have already strengthened, where gaps may remain, and which specific actions can help us to improve our own learning, well-being, and performance. Because the purpose of this 5 Phase Framework is not simply to collect more information about the brain. It is to understand how the systems connect—and then use that understanding to create meaningful change.  “Attention Is the Gate—How Movement Becomes Learning.” For today's Episode 406, we'll connect Dr. John Medina's Brain Rules to the Movement Loop we have been building throughout Phase 3—and answer the next important question: Once movement activates and prepares the brain, what determines whether that readiness becomes lasting learning? You can review our full interview with John Medina from EP 42[ii] from February 2020. (find the link in the reference section of the show notes). INTRODUCTION: THE MISSING STEP We have spent this phase so far, examining how movement changes the brain. Dr. Chuck Hillman and Paul Zientarski[iii] showed us that movement prepares the brain for learning. Dr. John Ratey[iv] helped us understand how exercise influences neurochemistry, BDNF, and neuroplasticity. Dr. Kristen Holmes[v] showed us that recovery helps determine whether strain becomes adaptation. And our restorative-sleep episode explored where some of that recovery, adaptation, and integration may occur. But one important question remains: A brain can be activated, chemically prepared, and physiologically ready—but what determines what it actually learns? The answer begins with attention. Movement may create the readiness to learn, but readiness alone is not learning. The brain must still select what matters, focus on it, interact with it, encode it, revisit it, and eventually integrate it. That gives us the pathway we will explore today: Movement creates readiness. But what is the filter in our brain that helps us to focus on the things that are most important to us. What gives us the ability to pay attention to something? The RAS- or The Reticular Activating System. Before we continue, let's remind ourselves what the RAS is. The RAS—or reticular activating system—is a network of neurons extending through the brainstem that helps regulate wakefulness, alertness, and our readiness to respond to incoming information. We explored this system previously in Episode 272, “Priming the Reticular Activating System to Achieve Our Goals.” In that episode, we described the RAS as a type of filter that helps us notice information connected to what we have identified as important. For example, once you decide that you are interested in a particular type of car, you may suddenly begin seeing that car everywhere. That's the RAS filtering system in our brain. The cars were already there, but your attention now has a reason to prioritize them. In Episode 272[vi], we applied this idea to goal-setting. When we clearly identify an intention, we may become more likely to notice relevant information, opportunities, and connections that were previously present but did not receive our attention. That explanation gave us a useful starting point. But here in Episode 406, we can add more precision. The RAS is not a tiny gatekeeper sitting in the brain and personally deciding what we will learn. It is part of a broader network that helps maintain the level of arousal and alertness required for our attention. It helps the brain become available to notice whatever it is that is important to us. Then salience, relevance, emotion, intention, and our current goals help determine what receives priority. Focused attention directs our limited cognitive resources toward the selected information. Next, encoding and repetition help strengthen what we want to focus on. And recovery and sleep help to further support its consolidation and integration. So our expanded Movement Loop now looks like this: you can see an image in the show notes to expand this understanding. Movement supports brain activation.   RAS helps the brain become awake, alert, and ready to pay attention. Salience and relevance (or what matters the most to us) helps to determine what receives priority. Our focused attention selects what gets our priority. Encoding and repetition further strengthens this pathway. Recovery and sleep (that we've dove deep into) support consolidation and integration. And together, these processes increase the likelihood that experience becomes learning—and that learning becomes available for future performance. Whatever it is that we have put our attention on, is now made usable.  This shows us how our understanding has evolved since Episode 272, three years ago. Then, we were asking: How can our intention help us notice what matters with the attainment of our goals? Now, years later, with more understanding, we are asking: Once the brain is alert and something important has captured our attention, what sequence of events must occur for that information to become lasting learning? We are no longer asking only what must remain top of mind so we can notice opportunities connected to our goals. We are asking what happens next: How does something we notice become something we understand? How does something we understand become something we remember? And how does something we remember become knowledge or a skill we can retrieve, apply, and use to improve our performance? This is where Dr. John Medina's Brain Rules help us to connect the pieces. Let's begin with Lesson One: Lesson 1: Movement Creates Readiness—Not Guaranteed Learning Movement can increase alertness, circulation, and readiness for cognitive work. But why might movement have such a powerful relationship with the brain? Dr. John Medina explains this through an evolutionary lens. His point is that the human brain did not develop while we were sitting motionless at desks or staring at screens. It developed while human beings were moving through changing outdoor environments, solving immediate problems, and continually responding to the world around them. Let's listen to how he explains it. CLIP 1 John Medina “The human brain was designed to solve problems related to surviving in an outdoor setting, in unstable meteorological conditions—and to do so in constant motion. The constant motion is where the exercise comes in. But the rest of that—the more a school, or any of us, can recreate the world of the Serengeti, the place where this brain actually grew up, the better things are. And exercise, particularly outdoor exercise, is a terrific example of this idea.” When Medina refers to the Serengeti, I don't think he is suggesting that schools should literally recreate the dangers or conditions of an ancient environment. He is giving us an evolutionary picture of the conditions under which the human brain developed: We moved. We navigated changing environments. We encountered new sensory information. We solved problems. We adapted to uncertainty. And we did these things together rather than remaining physically still for most of the day. Outdoor movement may bring several of these conditions together. We are moving our bodies while also responding to changes in light, temperature, terrain, sound, distance, and direction. This helps explain why movement belongs at the beginning of our Movement Loop. But it also brings us to an important distinction: Movement creates readiness. It does not guarantee learning. A student can move before class and still become distracted. A leader can exercise before work and still spend the morning reacting to notifications. An athlete can warm up physically without becoming mentally focused on the strategy or skill required next. Movement can help activate the system. The RAS in the brain helps us become awake and alert. But the brain must still determine what stands out, what is relevant, and what deserves focused attention. Movement opens the window. Attention determines what enters through it. Our Key lesson: Movement prepares the brain. Attention directs the preparation. PUT THIS INTO ACTION Before your next period of demanding cognitive work, use movement to create a window of readiness. Take a five-to-ten-minute walk, complete a brief movement break, stretch, or choose another form of movement appropriate for your ability and environment. But do not move without deciding what comes next. Before you begin, identify the specific task you will return to: “When this movement break ends, what will receive my attention?” For a student, it might be the first problem on a math assignment. For a leader, it might be the one decision that requires uninterrupted thinking. For an athlete, it might be the cue, strategy, or skill that needs to remain at the center of practice. Movement creates the opportunity. A clear intention helps direct what happens next. Your experiment is: Move briefly, choose one target that you want to complete with this intention, and begin that task immediately after the movement ends. Lesson 2: Attention Is the Gate In EP 395[vii], we examined what captures attention: Meaning Emotion Relevance Intention Reward Human connection Now today's episode shows how we move beyond why the brain notices something and explains what attention does after movement has prepared the system to learn. Attention acts as a filter. The brain encounters more information than it can consciously process, so it must select what receives priority. This creates the bridge: Brain activation creates capacity. Attention distributes that capacity. Our Key lesson: What the brain does not attend to has little opportunity to become lasting learning. Andrea's Application This distinction between brain capacity and cognitive efficiency became personal for me when I reviewed the results of my 2020 brain scan. We covered this topic on EP 84[viii] and we will do a thorough review of what was learned with our brain scans at Dr. Daniel Amen's CA Clinic. The evaluation that I received after my scan was completed with Dr. Shane Creado, suggested that I had areas of strong capacity, but that my brain appeared to be working harder than necessary to complete certain tasks in the cognitive testing. A possible contributor we discussed was sleep deprivation. I want to be careful here: a SPECT scan is not a direct measurement of attention or learning, and my results cannot tell us that insufficient sleep caused a specific attention pattern. But the experience gave me a useful way to think about what we are learning today. Having cognitive capacity does not necessarily mean that we are using that capacity efficiently. I may be motivated, active, and ready to work—but if I am under-recovered, under-slept, distracted, or trying to process too many competing inputs, my brain may have to expend more energy to sustain focus. This helped me understand the Movement Loop at a more personal level: Movement can help activate my brain. Attention gives that activation a target. But recovery may influence how efficiently I can sustain that attention and use it for learning. My scan did not define what my brain could do. It gave me another reason to examine the conditions under which my brain performs at its best. PUT THIS INTO ACTION Before asking yourself—or someone else—to focus, make the target of attention clear. Start by completing this sentence: “The most important thing to notice right now is…” Then reduce the competition around it. We all know to do this. Silence unnecessary notifications. Close unrelated tabs. Remove extra materials from view. Avoid asking the brain to switch repeatedly between tasks. If you are teaching, make the relevance visible: “Why does this matter?” “What should students be listening or looking for?” “How does this connect to something they already know?” If you are working independently, write your one priority clearly where you can see it. Remember, the goal is not to force the brain to attend to everything. The goal is to help it identify (with your RAS-that filter in your brain) what deserves your priority. Your experiment is: Choose one target, (something you want to accomplish) remove as many unnecessary sources of interference as possible, and create one meaningful reason to pay attention. This also helps explain why keeping your desk clear, your closet organized, or your car tidy may make you feel calmer and more focused. How we do anything is how we do everything. Every object, notification, unfinished task, or piece of visual clutter can become another potential signal competing for your attention. That does not mean everything must be perfectly organized before you can begin (while some of us would prefer to work this way), perfection can become its own form of interference. Just get started. It simply means that when you reduce unnecessary visual and mental competition, you make it easier for the brain to recognize the priority in front of you. Clear the space. Name the target. Create the relevance. Then give the task your full attention. Lesson 3: Attention Is Necessary—but It Is Not Enough Paying attention to information once does not guarantee that it will be remembered. This is where Dr. Medina's memory rules enter: Repeat to remember. Remember to repeat. The first refers to giving new information more than one opportunity to be encoded. The second points toward revisiting information over time. This allows you to extend the Movement Loop: Movement prepares the brain and body. Attention selects what to focus on. Retrieval and Repetition strengthens our focus. Recovery helps us to integrate what we are learning. PUT THIS INTO ACTION After learning something new, do not immediately reread it. First, look away from the material and try to retrieve it. Ask yourself: “What were the three most important ideas?” “How would I explain this without looking at my notes?” “What can I remember on my own?” Retrieval reveals the difference between recognizing information and actually being able to access it. Then return to the material, check what you missed, and retrieve it again later—after an hour, the next day, or several days afterward. For students, this could mean closing the textbook and explaining the lesson to a partner. For professionals, it could mean summarizing a meeting before reviewing the notes. For personal learning, it could mean recording a short voice memo explaining the idea from memory. Your experiment is: Learn it once, retrieve it without looking, and schedule a brief return to it later. See if you can remember it. Attention begins the pathway. Retrieval and repetition help strengthen it. Andrea's Application This lesson reminded me of one part of the cognitive testing that accompanied my brain scan at Amen Clinics: a Continuous Performance Test, or CPT. In the version I completed, letters appeared on a computer screen. The instruction was to press a button whenever a letter appeared—except when the letter was X. This type of task may sound simple, but it requires you to remain attentive over time, respond consistently, and inhibit your automatic response when the target letter appears. My results indicated that this was an area in which I did not perform as strongly. Looking back, I remember hearing the basic instruction: press the button for every letter except X. But I do not remember fully appreciating that the speed and consistency of my responses also mattered. This gave me an important real-life lesson: Hearing an instruction is not the same as accurately encoding everything the task requires. Before beginning something important, pause and ask: “What exactly am I being asked to do?” “What details determine successful performance?” “Can I explain the instructions back in my own words?” And, when appropriate, write down the key steps before beginning. This applies in a classroom, during a meeting, while completing an assessment, or whenever accuracy matters. First, attend to the full instruction. Then restate or retrieve it. Clarify anything that is missing. And only then begin the task. My experience showed me that attention is not just about working harder or concentrating more intensely. It is also about identifying the correct target—and making sure we understand the complete task before directing our effort toward it. Lesson 4: Learning Becomes Stronger When It Has More Than One Path Dr. Medina's Brain Rule #9 about sensory integration and vision(meaning our brains learn and remember best when multiple senses—like sight, sound, and touch—are engaged at the same time) give you the practical learning background to involve ALL of your senses. While teaching and learning you can ask: Can I see it? Can I hear it? Can I explain it? Can I demonstrate it? Can I connect it to something I already know? Can I apply it physically or practically? The goal is not sensory stimulation for its own sake. It is to provide clear, relevant pathways through which the learner can interact with the information. Our Key lesson: The more meaningfully we interact with information that we are learning, the more opportunities the brain has to encode and retrieve it. PUT THIS INTO ACTION Choose one idea you want to remember and interact with it in at least two meaningful ways. You might: See it in a diagram. Hear it explained. Say it in your own words. Write or draw it. Teach it to someone else. Demonstrate it physically. Connect it to a previous experience. Or apply it to a real problem. The goal is not to add noise or stimulation. More input is not automatically better. Each interaction should make the idea clearer, more relevant, or easier to retrieve. For example, instead of only reading about the Movement Loop, you could draw the sequence, explain it aloud, and identify where it appears in your own daily routine. Your experiment is: Take one important idea and represent it in two different, meaningful ways. The more deeply we work with information, the more opportunities the brain has to encode and retrieve it. Andrea's Application If you have been listening to this podcast for a while, I'm sure you have noticed that when I organize an idea into a framework—or represent it in a visual graphic—it begins to come to life. I can see how the pieces from past episodes connect, can explain the concept more clearly, and retrieve and apply it to my life more easily. It's also difficult to forget something when there's a visual image connected to it if you are the type of learner who needs to see something to make it stick in your memory. LESSON 5: RECOVERY HELPS LEARNING CONTINUE AFTER ATTENTION ENDS So far, we have followed learning through four important steps: Movement prepares the brain and body. RAS helps “turn on the lights,” allowing us to become awake, alert, and ready to respond. Next, the brain begins identifying what might be important to us. Salience refers to something that stands out—perhaps because it is new, unexpected, emotional, or connected to a possible reward or threat. Relevance refers to how closely that information connects to our goals, needs, experiences, or interests. In simple terms: Salience asks, “What stands out?” Relevance asks, “What matters to me?” Attention through the RAS next directs the brain's spotlight toward the information selected for deeper processing. Imagine a flashlight shining on whatever it is that you have picked to be important to learn. Encoding creates the initial memory. Retrieval and repetition strengthen it. But learning does not necessarily end when we close the book, leave the classroom, finish the meeting, or stop practicing. The brain still needs time to stabilize, organize, and connect what we learned. This is where recovery and sleep enter the Movement Loop. SLEEP IS AN IMPORTANT PART OF LEARNING Sleep is not a period when the brain simply switches off. While we sleep, the brain continues processing information from the day. Newly encoded memories may be reactivated, strengthened, reorganized, and connected with knowledge we already have. This is called memory consolidation. In simple terms, consolidation helps make a new memory more stable and easier to access later. Deep non-REM sleep and REM sleep may support different but overlapping parts of this process. Deep sleep is associated with physical restoration and the consolidation of certain facts and experiences. REM sleep has been associated with emotional learning, procedural skills, creative connections, and integrating new experiences with older memories. But we should not think of these as completely separate jobs. Deep sleep and REM are parts of a repeating sleep cycle, and both may contribute to learning. This is why I use the phrases: Deep sleep helps me recover from the hard work I did that day. REM may help me integrate what I experienced and what it meant to me. The word “may” matters because sleep is more complex than saying that deep sleep only restores the body and REM alone integrates learning. The most important lesson is this: What we focus on while we are awake gives the brain something to work with while we sleep. Retrieval and repetition strengthen the information before sleep. Then sleep provides conditions that can help stabilize, organize, and connect what we learned. THE MOVEMENT LOOP IN SIMPLE TERMS Let's put the complete cognitive side of the Movement Loop into simple language. MOVE—to prepare the brain and body. BECOME READY—RAS- in the brain helps us become awake, alert, and available to respond. NOTICE—salience helps something stand out because it is new, emotional, unexpected, rewarding, or potentially threatening. RELEVANCE—relevance helps the brain recognize how that information relates to our goals, needs, interests, or previous experiences. ATTENTION—directs our mental resources or a spotlight toward the selected information. ENCODE—begins forming a memory of what we are focused on. RETRIEVE AND REPEAT—strengthens the memory and makes it easier to access again. RECOVERY and CONSOLIDATION—so the brain and body can restore, and sleep can support memory consolidation. Leading us to-- INTEGRATION—to connect the new learning with what we already know. APPLY—Making the learning available and ready to use when we need it. So, in its expanded form, the Movement Loop looks like this: Movement → RAS-Supports Readiness → Salience and Relevance (what's important to us)→ Focused Attention → Encoding (forms the memory of what we are focused on)→ Retrieval and Repetition (to strengthen the neural pathway) → Recovery and Consolidation (important for the brain and body to be rested and recovered)→ Integration (connect new learning with what we already know)→ NEW Learning and Performance (ready and available for us whenever we need it). Here is an even easier way to remember how we LEARN: Move. Wake or Get Ready. Notice. Focus. Form a Memory. Strengthen it. Recover it. Connect it. Use it. Movement prepares the system. The RAS helps us become alert. Salience and relevance identify possible priorities. Attention selects the target. Encoding begins the memory. Retrieval and repetition strengthen it. Recovery and sleep help stabilize it. Integration connects it. And application makes it useful. These stages do not always occur in a perfectly straight line. We may notice something before we are fully focused on it. We may need several rounds of encoding and retrieval. We may sleep on an idea and understand it differently the following day. Or we may try to apply what we learned and discover that part of the pathway still needs strengthening. That is why this is a loop rather than a one-way process. Application produces feedback. That feedback shows us what we understand, what we can retrieve and use, and what still requires attention, repetition, or recovery. Then that feedback guides the next cycle of learning. We move again. We become ready. We direct our attention toward what matters. And with each cycle, we build learning that becomes more accessible, adaptable, and useful in our performance. PUT THIS INTO ACTION Before ending your next learning or work session, take one minute to ask: “What is the most important thing I want to remember?” Without looking at your notes, write down the central idea in your own words. Then decide when you will retrieve it again—perhaps later that day or the following morning. After that, give yourself permission to recover. When your attention is fading, another exhausted hour may not be as valuable as a break or a full night of sleep. The following day, try to retrieve the idea again before looking at your notes. Notice what remained accessible and what needs another repetition. Your experiment is simple: Summarize it. Sleep on it. Retrieve it again. Because learning begins while we are awake—but recovery and sleep help the brain continue the work. The Move–Focus–Learn Protocol BRINGING THE FIVE ACTIONS TOGETHER Here is the full Move–Focus–Learn experiment: Test this in school, work or personal learning: Use a brief walk or appropriate movement break before demanding cognitive work. This is what I told Dr. Medina 6 years ago is the only way I'm able to stay focused on writing difficult topics, like this one. Identify the one thing that deserves your attention next. Pick one priority you will focus on. Remove interference. Reduce unnecessary notifications, competing tasks and distractions. This can take a few minutes ahead of time, but keeps the learning slate clean so to speak. Create relevance. Ask, “Why does this matter to me—or to this learner?” Interact with the information you want to learn. Explain it, visualize it, discuss it, demonstrate it or apply it. Retrieve it. Close the book or screen and recall the important ideas without looking. Repeat it later. Return to the information after time has passed. Protect recovery. Allow sleep and recovery to support the next stage of learning. REVIEW AND CONCLUSION As we close out Episode 406, I want to return to the question we began with: Once movement activates and prepares the brain, what determines whether that readiness becomes lasting learning? The answer is not one single process. Learning emerges through a sequence of connected conditions: The brain and body must become ready. Something must stand out and feel relevant. Attention must select it. The information must be encoded. It must be retrieved and revisited. And recovery and sleep must provide opportunities for consolidation and integration. Dr. John Medina's Brain Rules helped us follow this sequence through five key lessons. LESSON 1: EXERCISE PREPARES THE BRAIN Movement helps create biological conditions that support alertness, attention, and cognition. The RAS contributes to this process by helping us become awake, alert, and ready to respond. But movement creates an opportunity—not a guarantee. A prepared brain still needs direction. LESSON 2: ATTENTION SELECTS WHAT MATTERS The brain encounters far more information than it can consciously process. Salience helps us notice what stands out. Relevance connects that information to our goals, needs, interests, or previous experiences. Attention then directs the brain's spotlight toward the selected target. Movement may create greater readiness, but attention determines where that readiness goes. LESSON 3: RETRIEVAL AND REPETITION STRENGTHEN WHAT ATTENTION BEGINS Paying attention once may create familiarity, but familiarity is not the same as learning. Encoding begins the memory. Retrieval asks the brain to locate that information again. Repetition gives us additional opportunities to strengthen our access to it. This is why explaining an idea without looking at our notes can be more useful than simply rereading it. Attention begins the pathway. Retrieval and repetition help make it last. LESSON 4: MEANINGFUL INTERACTION HELPS LEARNING STICK We can strengthen encoding by interacting with an idea in more than one meaningful way. We might see it, hear it, explain it, draw it, demonstrate it, or apply it. The goal is not to add as much stimulation as possible. The goal is to give the brain clear and relevant ways to understand, represent, and later retrieve the information. This is something I have experienced while creating this podcast. When I organize an idea into a framework or bring it to life in a visual graphic, I can see how the pieces connect. That helps me explain the idea more clearly, remember it more easily, and apply it more effectively. LESSON 5: RECOVERY ALLOWS LEARNING TO CONTINUE Learning does not necessarily end when we close the book, leave the classroom, finish the meeting, or stop practicing. During sleep, newly encoded information may be reactivated, stabilized, reorganized, and connected with existing knowledge. Deep non-REM sleep and REM sleep may contribute to this process in different but complementary ways. This is why recovery is not separate from learning. Recovery is part of the learning process. PUTTING THE MOVEMENT LOOP TOGETHER The complete cognitive side of the Movement Loop now looks like this: Movement prepares the brain and body. RAS-supported arousal helps us become awake and alert. Salience and relevance help identify possible priorities. Attention selects the target. Encoding begins the memory. Retrieval and repetition strengthen it. Recovery and sleep support consolidation. Integration connects the new learning with what we already know. And application makes that learning available when we need it. Or, in its simplest form: Move. Wake. Notice. Focus. Form. Strengthen. Recover. Connect. Use. Movement creates readiness. Attention provides direction. Encoding begins the memory. Retrieval and repetition strengthen the pathway. Recovery supports consolidation and integration. And application turns what we have learned into improved performance. Together, these processes help turn activity into lasting learning. FINAL THOUGHT This is not the first time we have explored Dr. John Medina's work, but each return has allowed us to ask a different question. In Episode 42[ix], we asked: How should schools and workplaces change when we understand the brain? In Episode 370[x], we asked: How can neuroscience and emotional regulation improve learning environments? In Episode 395[xi], we asked: What captures attention and motivates behavior? And here in Episode 406, we asked: How does an activated and attentive brain convert an experience into learning? That question has helped us add important detail to the Movement Loop. Movement alone does not create learning. Attention alone does not create lasting memory. Repetition without meaning may not produce understanding. And effort without recovery may not give the brain the conditions it needs to consolidate and integrate what happened. Each part of the process matters. Before we close, consider these questions: What are you preparing your brain to notice? Where is your attention going after you move? Are you interacting with important information deeply enough to encode it? Are you retrieving what you are learning—or merely rereading it? And are you protecting the recovery that allows learning to continue? Because what we repeatedly attend to, retrieve, and apply begins to shape what we know, what we can do, and how we perform. PREPARING FOR EPISODE 407 Movement can prepare the brain. Attention can direct it. Encoding can begin the memory. Retrieval and repetition can strengthen it. And recovery can help consolidate and integrate it. But every part of this process requires energy. The brain needs energy to direct attention, form memories, regulate behavior, and sustain performance. The body needs energy to move, adapt, recover, and begin the cycle again. So in Episode 407, we will revisit Jason Wittrock's work through a more current and carefully defined lens. We'll examine his experience with nutrition and fasting as an applied practitioner and personal case study, while comparing those ideas with current evidence surrounding nutrition, blood-sugar stability, metabolic flexibility, recovery, and performance. Because the brain and body cannot sustain performance without the energy required to power the system. I'll see you next time as we ask: How does metabolic health influence our capacity to move, learn, recover, and perform? RESOURCES Clip 1 with Dr. John Medina https://www.youtube.com/shorts/zDItOHAc8qQ Full Interview with Dr. John Medina https://www.youtube.com/watch?v=CFzg5nQnEMs REFERENCE   [i] John Medina's Brain Rule #4 https://brainrules.net/article/attention/   [ii] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 42 with Dr. John Medina on “Implementing Brain Rules in Schools and Workplaces of the Future” https://andreasamadi.podbean.com/e/dr-john-medina-on-implementing-brain-rules-in-the-schools-and-workplaces-of-the-future/   [iii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 403 https://andreasamadi.podbean.com/e/movement-first-how-a-20%e2%80%91minute-walk-lights-up-the-brain/     [iv]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 404 https://andreasamadi.podbean.com/e/movement-matters-how-every-move-rewires-the-brain/   [v] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 405 https://andreasamadi.podbean.com/e/movement-isnt-enough-how-recovery-drives-real-adaptation/   [vi]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 272 https://andreasamadi.podbean.com/e/brain-fact-friday-on-priming-the-reticular-activating-system-to-achieve-our-goals-in-2023/   [vii] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 395 https://andreasamadi.podbean.com/e/theory-of-mind-the-missing-link-between-attention-reward-and-motivation/   [viii]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 84  https://andreasamadi.podbean.com/e/how-a-spect-scan-can-change-your-life-part-3-with-andrea-samadi/   [ix] Neuroscience Meets Social and Emotional Learning Podcast EPISODE 42 with Dr. John Medina on “Implementing Brain Rules in Schools and Workplaces of the Future” https://andreasamadi.podbean.com/e/dr-john-medina-on-implementing-brain-rules-in-the-schools-and-workplaces-of-the-future/   [x]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 370 https://andreasamadi.podbean.com/e/brain-rules-revisited-how-neuroscience-can-transform-classrooms/   [xi]Neuroscience Meets Social and Emotional Learning Podcast EPISODE 395 https://andreasamadi.podbean.com/e/theory-of-mind-the-missing-link-between-attention-reward-and-motivation/      

## Podcast-Beschreibung Was bewegt die Allgemeine Luftfahrt aktuell? In dieser Folge von „Hast du schon gehört?“ sprechen wir über wichtige News aus der General Aviation, neue Entwicklungen bei Flugsicherheit, Luftrecht und Technik sowie über spannende Fly-Ins und Aviation-Events. Bei Siebert Luftfahrtbedarf steht nach 37 Jahren ein Generationenwechsel an. Yannick Weichert übernimmt die Geschäftsführung und führt das Traditionsunternehmen in die nächste Generation. Elektrisches Fliegen wird ebenfalls konkret: Beim Green Aviation Hub Fly-In am Flugplatz Traben-Trarbach steht gemeinsam mit Pipistrel die Zukunft nachhaltiger Antriebe im Mittelpunkt. Elektroflugzeuge können dort nicht nur am Boden, sondern auch im Flugbetrieb erlebt werden. Auch im Segelflug gibt es Neuigkeiten: Der Angelika Machinek Förderverein hat die Bewerbung für sein Förderflugzeug LS8 für die Saison 2027 geöffnet und unterstützt damit ambitionierte Segelflugpilotinnen auf dem Weg in den Leistungssport. Technisch spannend wird es bei der Beechcraft Denali. Der neue Single Engine Turboprop von Textron Aviation befindet sich in der finalen Flugerprobung. GE Catalyst Triebwerk, FADEC, Garmin G3000, Emergency Autoland, rund 285 Knoten Reisegeschwindigkeit und etwa 1.600 NM Reichweite machen die Denali zu einem interessanten Konkurrenten für PC-12, TBM und andere leistungsstarke Turboprops. Ein Schwerpunkt dieser Folge liegt auf der Flugsicherheit und den Human Factors. Wir sprechen über Stress, Entscheidungsfindung, Kommunikation und CRM im Cockpit – und über die Frage, warum Erfahrung allein nicht automatisch vor Fehlentscheidungen schützt. Dazu schauen wir auf die Flugsicherheitsstatistik 2026 des DAeC. Besonders auffällig: Viele schwere Ereignisse passieren während Start, Anflug und Landung. Technische Defekte stehen dabei deutlich seltener im Mittelpunkt als menschliche Faktoren wie Kontrollverlust, mangelnde Luftraumbeobachtung, schlechtes Entscheidungsmanagement oder das Festhalten an einem Plan trotz verschlechterter Bedingungen. Auch beim Thema Transponder gibt es immer noch gefährliche Missverständnisse. Wir sprechen über Transponderpflicht, Ground- und ALT-Modus, ADS-B Out, SIL-Werte sowie darüber, warum ein eingeschalteter Transponder ein wichtiger Bestandteil moderner Kollisionswarnsysteme ist. Weitere Themen dieser Folge: Neuer Präsident beim Luftfahrt-Bundesamt: Alexander Schott übernimmt das LBA und setzt Schwerpunkte bei Digitalisierung, Nachhaltigkeit und Flugsicherheit. Die EASA veröffentlicht mit ENCODE ein neues Werkzeug für die Lärmschutzzertifizierung und soll damit Zulassungen und Modifikationen in der General Aviation vereinfachen. Wir klären die Rechtslage zur UL-Schleppberechtigung und warum Flugstunden auf klassischen E-Klasse-Flugzeugen nicht einfach auf die erforderliche UL-Erfahrung angerechnet werden können. Außerdem geht es um die neuen Regeln zur Eigenstaffelung in Deutschland und darum, unter welchen Bedingungen Piloten selbst Verantwortung für den Abstand zu anderem Verkehr übernehmen können. Und wir schauen in die USA: Die FAA testet mit „Mobile Clearance“ digitale IFR-Freigaben direkt auf Tablet und Electronic Flight Bag. ForeFlight, Garmin Pilot und moderne Avionik könnten damit künftig einen weiteren Teil des klassischen Funkverkehrs digitalisieren. Zum Abschluss gibt es wie immer die aktuellen Aviation-Termine: Flugplatzfeste, Fly-Ins, die Deutsche Meisterschaft im Ultraleichtfliegen, das Rotax Fly-In, Texel Wings over Holland, das Boller Fly-In, das Burger Fly-In und weitere Veranstaltungen für Privatpiloten und Luftfahrtbegeisterte. General Aviation, Privatpiloten, Flugsicherheit, Luftrecht, IFR, UL-Fliegen, Segelflug, neue Flugzeuge und aktuelle Aviation-News – kompakt zusammengefasst in einer neuen Folge der Privatpiloten-Lounge.

In this episode we speak with Alon Goren from UC San Diego about his work at the intersection of genomic technology development and chromatin biology. We discuss how his lab studies how the epigenome is regulated, how disruption of that regulation contributes to disease, and how technology can be improved to make results more robust and reproducible. We talk about his early interest in biology, how that developed through medical research training, and how a molecular biology lab shaped the direction of his career. He explains how curiosity about how cells and organisms work led him toward genomics and chromatin research. We then discuss several methods from his career, including early direct sequencing approaches for small amounts of DNA and RNA, ChIP-based methods for chromatin regulators, and work on improving ChIP-seq workflows. He explains why antibody choice matters, why monoclonal antibodies can improve reproducibility, and how automation helped scale the process. We also cover his work on spike-in normalization, including the risks of using exogenous chromatin incorrectly and the need for better safeguards in genome-wide comparisons. He describes a newer approach that uses two spike-ins to provide multiple checks on normalization. Finally, we discuss his work on short tandem repeats, zebrafish heart regeneration, and SIRT6-related polymerase pausing, as well as a newer platform that converts molecular interactions into sequencing-readable barcodes. He closes by stressing the importance of validation, careful protocol design, and methods that can be used reliably by multiple people. References Ram, O., Goren, A., Amit, I., Shoresh, N., Yosef, N., Ernst, J., Kellis, M., Gymrek, M., Issner, R., Coyne, M., Durham, T., Zhang, X., Donaghey, J., Epstein, C. B., Regev, A., & Bernstein, B. E. (2011). Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell, 147(7), 1628–1639. https://doi.org/10.1016/j.cell.2011.09.057 Busby, M., Xue, C., Li, C., Farjoun, Y., Gienger, E., Yofe, I., Gladden, A., Epstein, C. B., Cornett, E. M., Rothbart, S. B., Nusbaum, C., & Goren, A. (2016). Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. Epigenetics & chromatin, 9, 49. https://doi.org/10.1186/s13072-016-0100-6 Patel, L. A., Cao, Y., Mendenhall, E. M., Benner, C., & Goren, A. (2024). The Wild West of spike-in normalization. Nature biotechnology, 42(9), 1343–1349. https://doi.org/10.1038/s41587-024-02377-y Ben-Yair, R., Butty, V. L., Busby, M., Qiu, Y., Levine, S. S., Goren, A., Boyer, L. A., Burns, C. G., & Burns, C. E. (2019). H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development (Cambridge, England), 146(19), dev178632. https://doi.org/10.1242/dev.178632 Patel, L., Cao, Y., Xu, T., Modolo, E., Dishon, T., Zhang, L., Mendenhall, E., Heinz, S., Simon, I., Benner, C., & Goren, A. (2025). Improved spike-in normalization clarifies the relationship between active histone modifications and transcription. Genomics. https://doi.org/10.1101/2025.11.25.690627 Xu, T., Wang, J., Shin, Y., Cao, Y., Zhang, L., Modolo, E., Dishon, T., Fisher, J., Norton, M., Fry, C. J., Farjoun, Y., Mendenhall, E., Heinz, S., Benner, C., & Goren, A. (2026). Multiplexed measurements of protein-protein interactions and protein abundance across cellular conditions using Prod&PQ-seq. Genomics. https://doi.org/10.64898/2026.01.01.697286 Related Episodes Taking ChIP from Yeast to ENCODE to Enable Genome-Wide Regulatory Protein Mapping (Peggy Farnham) Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Six years ago, aged just 15, Sneha Revanur founded the AI advocacy nonprofit Encode AI — back when AI felt like a niche issue. Now the world's caught up with her, and she's ready to share everything she's learned about the politics of AI.Encode has grown from a grassroots youth organisation to spearheading an unlikely coalition of AI-exposed groups — family-first conservatives, grieving mothers, Hollywood actors, and AI safety researchers — with the strength to take on $125m-funded anti-regulation lobbyists.So far, Encode's strategy of taking many experimental swings has netted major victories (including California's frontier AI safety bill, SB-53, and New York's RAISE Act) as well as some disappointing setbacks.Going up against Big Tech hasn't been easy. In 2025, OpenAI subpoenaed Encode's general counsel at his home, with a sheriff's deputy arriving while he was having dinner with his wife. The fallout went viral, resulting in more attention than Encode had ever experienced — and Sneha was forced to decide how hard to push back against a company she'd need to negotiate with for years to come.In today's conversation, Zershaaneh Qureshi interrogates some of Encode's strategic moves. The pair discuss all the above, plus:How the AI industry's crypto-inspired anti-regulation strategy is not “AGI-pilled”Why AI advocacy doesn't have to be held back by the slow pace of policyHow mutual trust can hold together the unlikeliest of political alliesAdvice for aspiring AI advocates — including how to balance political persuasion with rigorous reasoning Due to technical issues, this episode was recorded across two days (May 26 and 28, 2026) and spliced together.Links to learn more, video, and full transcript: https://80k.info/SRChapters:Cold open (00:00:00)   Who's Sneha Revanur? (00:00:32)   Sneha's awakening to AI's deeper risks (00:01:16)   “If you do everything, you will win” (00:04:04)   Influencing politics from the outside (00:06:39)   The challenge of grassroots (00:11:16)   Mums, musicians, and conservatives vs Big Tech (00:14:21)   How vetoed bills can still provide wins (00:19:31)   OpenAI's subpoena, served at dinner (00:27:33)   How AI money plays in politics (00:37:19)   Easy wins vs high-upside bets (00:43:25)   Advice for aspiring AI advocates (00:48:03)   Our production team includes:Video editors: Josh Alward, Dominic Armstrong, Jasper Luithlen, Milo McGuire, Luke Monsour, Simon Monsour, and Andrés EscobarProducer: Nick Stockton and Elizabeth CoxCoordination and support: Katy Moore and Lou MoranMusic: CORBIT

Stephen C. Meyer has a PhD from Cambridge in the philosophy of science, and he thinks AI just handed him his strongest argument yet. I spent years pushing back on him. Today I laid three traps. Watch what he does with the third one. Subscribe if you want science with evidence, not speculation. Meyer is a philosopher of science and director of the Center for Science and Culture at the Discovery Institute. His argument: every large language model is trained on text produced by conscious agents, and when you query its own outputs iteratively, it collapses into incoherence. That dependency, he says, is a tell. AI can recombine information. It cannot originate it. And that distinction points, in his view, to something minds do that matter alone cannot explain. I push back on all of it. We go after the Oklo reactor, a natural nuclear fission reactor that ran for millions of years in Africa two billion years ago with no human input whatsoever. I ask whether that breaks his information-from-mind argument. He sees the trap before I spring it, concedes the point where concession is honest, and explains exactly where the threshold lies. We also get into the Wheeler-DeWitt equation and Vilenkin's admission that quantum cosmology may require a mind predating the universe, the junk DNA prediction that Meyer's team made in the '90s before the ENCODE project confirmed it, and why beauty in physics can lead a field astray. What you'll hear: - Why model collapse is Meyer's strongest argument and where it has limits - The Oklo reactor trap and what Meyer's honest answer reveals about design detection - What Vilenkin actually said about a mind predating the universe - Whether intelligent design makes testable predictions or only retrodictions - The junk DNA call and what the ENCODE project found - Why beauty as a guide to physics has produced mathematical castles in the air Stephen Meyer thinks AI proves minds can't be reduced to matter. Is model collapse evidence of design, or is it just bad training data? CHAPTERS 00:00 The AI argument Meyer thinks no one can crack 00:44 What is inference to the best explanation? 05:52 AI has a tell: the model collapse problem 09:38 The Oklo trap: a natural nuclear reactor with no designer 11:56 Where the design inference becomes decisive and where it doesn't 15:50 Sean Carroll's wasteful universe problem and Meyer's answer 20:00 Where did atheist scientists get access to the mind of God? 23:22 The fine-tuning of the periodic table: why are there only 500 stable nuclei? 25:52 The universe had a beginning: observational astronomy and the Borde-Guth-Vilenkin theorem 27:40 Quantum cosmology: how math alone is supposed to birth a universe 29:08 Vilenkin's question: are we saying a mind predates the physical universe? 34:06 Mathematical castles in the air: where beauty in physics goes wrong 40:00 Does intelligent design make predictions or only retrodictions? 43:52 The junk DNA prediction and what ENCODE found 46:30 James Tour, origin of life, and the hidden hand of the investigator 51:56 God-of-the-gaps vs. inference to the best explanation 56:02 The Story of Everything: where to watch and what to expect Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1 Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join Featured Guest: Stephen C. Meyer website: https://stephencmeyer.org/ The Story of Everything (film, Amazon Prime June 25): https://www.primevideo.com/detail/0NO974XWBQQNYH9TB4ESIJIVL9 Signature in the Cell (book): https://signatureinthecell.com/ Return of the God Hypothesis (book): https://returnofthegodhypothesis.com/ My books: Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un Twitter/X: https://x.com/BrianKeating Substack: https://briankeating.substack.com Blog: https://briankeating.com/blog Audio-only: https://briankeating.com/podcast #intotheimpossible #briankeating #intelligentdesign #artificialintelligence #cosmology #podcast #StephenMeyer #philosophy Learn more about your ad choices. Visit megaphone.fm/adchoices

The Learning Leader Show with Ryan Hawk Read my NEW BOOK -- The Price of Becoming -  www.LearningLeader.com/Becoming Eric Ries is the author of The Lean Startup, one of the most influential business books of the past 25 years, and the founder of the Long-Term Stock Exchange, the first new U.S. exchange to both list and trade multiple stocks since NASDAQ launched 50 years ago. His new book is Incorruptible. Key Learnings The more successful a company becomes, the more valuable it is as a target. Companies are worth stealing and taking over. Most founders are naive about this and don't understand what's coming for them. They've been following the so-called best practices about how companies should be built, structured, and governed. Most of those best practices are value-destroying. Sol Price was a lawyer before he became an entrepreneur. He believed a lawyer had a fiduciary duty to put the client's interests before his own. So when he became a retailer, he asked: "Who's my client?" The customer. He treated the customer as the person he would rather die than betray. When competitors sold a product for less, he'd put up signs in his own store: "Don't buy this from me. You can get it cheaper somewhere else." He capped his margins at 14 percent. He paid above-market wages. It is so much easier to destroy than to create. One day, Sol came into work and couldn't get into his office because the locks had been changed. Investors had pushed him out and forced Fedmart to practice retail best practices. Within seven years, they bankrupted the company. We've built an economy that rewards people for cost-cutting without holding them accountable for the consequences to trustworthiness, brand, or culture. The origin story of Costco: Sol took two weeks off, then leased the office upstairs from Fedmart and started Price Club. One of the young guys who left with him, Jim Sinegal, had worked his way up from stock boy. Jim eventually started his own company using the Sol ethos. A few years later, their companies merged to form what we now call Costco. Wall Street routinely calls Costco the exception to every rule. Wall Street analysts say things like: "At Costco, they take money that rightfully belongs to shareholders and instead invest it in the customer experience." As if that's a criticism. Costco endures because it's protected by a governance fortress. A series of worst practices that resist outside pressure structurally. The $1.50 hot dog has been the same price since 1986. A McDonald's Big Mac was $1.60 in 1986. Today that same Big Mac in California is over $7. Costco sells more hot dogs than every Major League Baseball stadium in America combined. If they raised the combo to $7, it would be a billion dollars of extra net income. They could do it. They choose not to. "If you raise the price of the effing hot dog, I will kill you. So figure it out." Jim Sinegal said it to his COO in 2008 when costs were rising. Figure it out. Costco vertically integrated the hot dog supply chain. They own hot dog production plants in multiple cities. They worked deals with soda vendors. They did all that extra work for the privilege of not making more money on the hot dog. Harder is easier. "When you take the hard road, when you make a principled commitment, you get these almost unbelievable values. Because you're generating the most underrated and most valuable asset in all of business: trustworthiness." "Easy choices, hard life. Hard choices, easy life." Jerzy Gregorek, Olympic weightlifter. "Everybody wanna be a bodybuilder. Nobody wanna lift these heavy ass weights." Ronnie Coleman, eight-time Mr. Olympia. Everyone wants the outcome. Nobody wants to do the actual thing. Culture and mission can be cultivated, not commanded. Most leaders get this wrong. They say "I'm in charge of my team." But can you command your team to have integrity? Can you command it to have a particular culture? You have to make consistent, responsible choices, just like cultivating health in your body. Get reps. Eric gave practice talks at a Hobee's restaurant at 7 AM to six people just to get the reps. Caring and trying to do a good job is so unbelievably rare. That alone is a competitive advantage. Feedback tells you something about the person giving it, not about yourself. If someone reads Eric's manuscript and says, "This book sucks," he hasn't learned anything about the book. He's learned this person doesn't like this kind of book. When he stopped arguing with negative customer reviews and started studying who they came from, he noticed patterns. People 16 and younger loved the product. People 16 and older hated it. He learned who his product was for. Separate qualitative from quantitative feedback. Qualitative is for hypothesis generation. Quantitative is for hypothesis validation. When test readers told him a chapter wasn't working, that was qualitative. When the platform data showed nobody was getting past that chapter, that was quantitative. You need both to know what to fix. It is always too early until it's too late. Eric tells the story of a multibillion-dollar founder he warned before his IPO. The founder talked to his bankers, lawyers, and CFO. They told him Eric was a downer. The founder went public anyway with conventional governance. Five months later, his stock dropped 90 percent, and he was ousted. The best time to plant a tree is 40 years ago. The second-best time is today. Eric's checklist for building an incorruptible company: Encode your mission into the corporate charter. Most founders have never read their charter. If your mission statement says one thing but your legal charter says another, you're lying. The easiest fix: file a public benefit corp filing (PBC). Two pages. 44 states. Your lawyer can do it tomorrow. Identify your fiduciary commitments. Who would you rather die than betray? Is it your customers? Your employees? Product quality? You decide. If your answer is nobody, you're a sociopath. The whole book is for the people who actually want to accomplish something. Align your employees to that mission. Make sure everybody on the team is committed to the same fiduciary priority. Create a director's oath. Like the Hippocratic Oath for doctors, but for your board. They must pledge to commit to the company's mission. Board betrayal and investor pressure are leading causes of death of companies in the modern world. Make the directors accountable to somebody. Power without accountability is corrosive to the human spirit. Novo Nordisk is governed by a nonprofit foundation. Patagonia is governed by a perpetual purpose trust. John Lewis Partnership in the UK is governed by an employee ownership trust. IKEA, Vanguard, and REI all have these structures. The data shows these companies are dramatically more stable and higher performing than conventional structures. You are not stuck in traffic. You are traffic. People love to blame the system. But you're not just a passenger. You're part of what creates the system. Where you work. What you buy. What you give your attention to. Every one of those choices is fueling somebody's company, somebody's algorithm, somebody's bonus. The richest people in the world spend billions on PR because they know your individual choices matter. Use that power. Eric's champagne moment a year from now: a grassroots movement around Incorruptible. This book won't get wall-to-wall media coverage. It's antagonistic to people in power. So Eric hopes readers will hand it to their founders, their bosses, their friends. If consumers and employees start demanding, "I want to work in an incorruptible company," that's the toast. Reflection Questions What is your equivalent of Costco's hot dog? The one commitment you'd defend even when it's financially painful, even when the easy move would be to abandon it? Have you ever read your corporate charter, or the foundational document of your team or department? Does what's actually written match what you say you stand for? Where in your work or life would the harder short-term path build something more durable in the long run? Are you willing to lift the heavy weights? More Learning #258: Jesse Itzler: Creating Your Life Resume & Living Outside the Box #529: James Clear: Setting Up Your Future Self & Becoming an Optimist #565: Noah Kahan: The Art of Asking For What You Want Podcast Chapters 00:00 The Price of Becoming - Pre-Order Now!  01:03 Meet Eric Ries  02:55 Is It Possible to Build an Incorruptible Company?  04:04 Why Culture Alone Won't Save You  05:13 Sol Price, Fedmart, and the Locks That Got Changed  07:56 Why Wall Street Calls Costco the Exception  09:11 The $1.50 Hot Dog Story  13:59 Harder Is Easier: The Principle Behind It All  16:48 Why Governance Is Just Soul Craft  19:50 Building the First New Stock Exchange Since Nasdaq  22:33 Eric's Communication Style: Reps, Not Talent  30:52 The Opportunity Hiding in Broken Markets  31:59 How to Know Which Feedback to Listen To  35:39 Qualitative vs. Quantitative: Why You Need Both  37:23 The Whole Foods Cautionary Tale  40:25 The Founder's Checklist for Building Something Durable  43:44 Encode Your Mission Into the Corporate Charter  47:35 You Are Not Stuck in Traffic. You Are the Traffic.  52:37 The Champagne Question: A Grassroots Movement  55:27 James Clear, Author's Equity, and the Future of Publishing 56:43 EOPC

Use positive words. Encode the micro-habit of not using swear words as each word you speak has an effect. And swearing at work and before clients is unprofessional.My latest book “The Wealth Money Can't Buy” is full of fresh ideas and original tools that I'm absolutely certain will cause quantum leaps in your positivity, productivity, wellness, and happiness. You can order it now by clicking here.FOLLOW ROBIN SHARMA:InstagramFacebookYouTube

What You'll Learn in This Episode Why Freddie hates the word “expert”… and the standard most people are skipping. The “puddles → lakes → oceans” model for positioning yourself so the market can actually place you. Why podcast guesting + LinkedIn is still the highest-leverage authority play for most founders and consultants. Freddie's take on platform ROI: why Meta is “cheap,” why YouTube is powerful but expensive to do well, and what ad pricing signals about authority. Why storytelling is still the #1 leadership tool (and why our brains are built for it). My favorite practical exercise for influence: the “10-one-thousand pause”—and why silence makes people tell you what they weren't going to tell you. A real-world reminder: if you've earned expertise and you're staying quiet, you may be depriving the world of what it needs from you.   Ideas Worth Stealing (and Using This Week) Fix your positioning before you fix your content. Most people try to post more, podcast more, “be everywhere”… while the market still can't answer: what exactly do you do, for whom, and why you? Freddie's puddles→lakes→oceans model is a clean way to build authority without diluting it. If you want authority, use authority platforms. Freddie's argument is simple: for most founders/experts, podcast guesting + LinkedIn is still the highest ROI move because trust is already built into the medium. Silence isn't awkward—silence is leverage. Try the “10-one-thousand” pause in one conversation this week. Don't weaponize it—just watch what happens when you stop filling space. People often reveal what matters most when you let the moment breathe.   Resources Mentioned Freddie Pullen — Recognized: recognized.global The Healthy Entrepreneur Podcast (Freddie's show) Listen on Spotify or Watch on YouTube Connect with Freddie on LinkedIn   -----   Freddie has worked with 200+ founders to build demand, waiting lists, and revenue directly through LinkedIn. Along the way, one thing became impossible to ignore... All buyers do this one thing before they buy: They educate themselves with content. They want to recognize you first. They discover you through a LinkedIn post. Then consume your POV through longer form content. Then decide whether you're the person they trust. That's how modern B2B buying actually works. But this didn't come from theory.   After leaving his role as Head of Product at the world's largest media company serving 500M monthly users and generating $300k per day, Freddie built two 6-figure businesses in 8 months and helped 200+ founders do the same. The results: Multi six-figure profit in 8 months Podcast launched to #1 in 9 countries on day one $100k+ per year generated from the podcast alone Built a $3BN+ network starting with under 10k followers 50+ qualified HOT leads every month, predictably Which is why the goal of content is to be obvious.   Freddie helps clients position themselves as the authority people already trust before they ever speak to them.   Today, AI is accelerating this, but only if it's trained on the right positioning. Freddie and his team use AI to: Encode your POV Multiply what already works Turn LinkedIn posts into sales assets You need a new ocean on LinkedIn - where you're undeniable to your ideal clients. That's why Freddie and his team built a positioning first, AI powered approach to LinkedIn.   https://freddiepullen.com/ https://www.linkedin.com/in/freddie-pullen/ https://www.instagram.com/freddiepullen --------John Bates provides 1:1 Executive Communications Coaching, both in-person and online. He also gets 92+ Net Promoter Scores for his large and small group leadership development trainings at organizations like Johnson & Johnson, NASA, Google, Intuit, Boston Scientific, and many more. Find more at https://executivespeakingsuccess.com.Sign up for his weekly micro-trainings for free at https://johnbates.com/mini-trainings and create a great leadership communications habit that makes you the kind of leader who inspires trust, loyalty, and connection.

In the allegory of Plato's cave, prisoners see the world only through shadows. Extending this metaphor to AI, AI models are the prisoners and the shadows are streams of data. Are all models converging on a singular representation of reality? On this week's episode of The Quanta Podcast, host Samir Patel speaks with staff writer Ben Brubaker about how, despite being trained on entirely different data types, different models can somehow develop similar internal representations. This topic was covered in a recent story for Quanta Magazine. Each week on The Quanta Podcast, Quanta Magazine editor in chief Samir Patel speaks with the people behind the award-winning publication to navigate through some of the most important and mind-expanding questions in science and math. Audio coda: The Cave: A Parable Told By Orson Welles, Produced by Counterpoint Films, directed by Sam Weiss, and illustrated by Dick Oden. https://www.acmi.net.au/works/65888–the-cave-a-parable-told-by-orson-welles/

In this episode of the Epigenetics Podcast, we talked with Peggy Farnham from the Keck School of Medicine at USC about her work on establishing the ChIP Method in mammalian cells. In this episode, we dive into the relationship between transcription factors, chromatin dynamics, and gene expression with Professor Peggy Farnham from the Keck School of Medicine at USC. Professor Farnham shares her profound insights into how her groundbreaking research has reshaped our understanding of gene regulation and its implications in cancer. We explore how she has been a pioneer in mapping the genome-wide landscape of regulatory proteins, illuminating the molecular logic behind transcriptional control and its disruption in cancer biology. The interview starts with her instrumental role in adapting chromatin immunoprecipitation (ChIP) technology from yeast to human cells. Professor Farnham reflects on the technical challenges she faced during this transition, such as the quest for visibility of signals in mammalian systems. Her ability to innovate and troubleshoot challenges led to significant advancements in techniques that allow for the rapid identification of transcription factor binding sites, fundamentally changing the landscape of epigenetic research. As the discussion progresses, we learn about Professor Farnham's active involvement in the ENCODE project, where she contributed to high-resolution mapping of transcription factors and regulatory elements in human cells. She articulates her appreciation for collaborative efforts in science, highlighting how working within a consortium harnesses the collective expertise of diverse research groups. This collaboration not only bolstered the credibility of the data produced but also propelled the field forward in understanding the complexity of gene regulation. Through her participation in various projects, such as the Psyc-ENCODE consortium and the Roadmap Epigenome Mapping Consortium, Professor Farnham shares insights into her investigation of epigenetic variations, particularly in relation to complex disorders like schizophrenia. Her findings underscore the nuances of enhancer variability among individuals and the implications for understanding disease mechanisms, thereby advancing our knowledge of genetic regulation and its contributions to diverse biological outcomes. Moreover, the episode highlights Professor Farnham's reflective understanding of emerging technologies in the field. She discusses the evolution of methods that allow researchers to investigate gene regulation at single-cell resolution, recognizing the significant implications these innovations have for our comprehension of cellular differentiation and the transcriptional landscape. References Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Molecular and Cellular Biology. 2001 Oct;21(20):6820-6832. DOI: 10.1128/mcb.21.20.6820-6832.2001. PMID: 11564866; PMCID: PMC99859. Wells J, Farnham PJ. Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods (San Diego, Calif.). 2002 Jan;26(1):48-56. DOI: 10.1016/s1046-2023(02)00007-5. PMID: 12054904. Rhie SK, Schreiner S, Witt H, et al. Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation. Science Advances. 2018 Dec;4(12):eaav8550. DOI: 10.1126/sciadv.aav8550. PMID: 30555922; PMCID: PMC6292713. Tak YG, Hung Y, Yao L, et al. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Research. 2016 May;44(9):4123-4133. DOI: 10.1093/nar/gkv1530. PMID: 26743005; PMCID: PMC4872074. Related Episodes The Effect of lncRNAs on Chromatin and Gene Regulation (John Rinn) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) The Future of Protein–DNA Mapping (Mitch Guttman) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

This short potent clip is from inside from the course - Your Most Abundant Year Ever. This course guides and teaches you how to profoundly change your reality to match your desires through practical application of deep spiritual principles. Join now during the enrollment sale! Enroll in Your Most Abundant Year Ever

Nels and Vincent explain research attempting to explain why among humans, females around the world live on average 5 years longer than males, but the trend is reversed in many birds, amphibians, and insects. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiEVO Links for this episode Join the MicrobeTV Discord server Sexual selection drives sex difference in adult life expectancy (Sci Adv) Timestamps by Jolene Science Picks 1:37:00 Nels – NIH Leadership Is Failing Early Career Researchers Vincent – Kennedy's Comments on Circumcision Are Only Going to Confuse and Shame Parents Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo@microbe.tv  

This week, Gov. Gavin Newsom of California signed a big package of A.I. and social media bills into law — including the first state law in the United States to regulate A.I. companions. We talk through what stood out to us in the package and whether these protections will work. Then, the subpoena that has the whole tech world talking. Nathan Calvin, general counsel at Encode, an A.I. safety advocacy group that has been critical of OpenAI, talks with us about why he thinks the company is investigating him. And finally, grab your opera glasses. It's time for the first edition of The Hard Fork Review of Slop.Guests:Nathan Calvin, vice president of state affairs and general counsel at EncodeAdditional Reading:California Regulates A.I. CompanionsOpenAI Thinks Its Critics Are Funded by Billionaires. Now It's Going After Them.We want to hear from you. Email us at hardfork@nytimes.com. Find “Hard Fork” on YouTube and TikTok. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

Years ago, I used to live by my to-do lists—checking boxes, chasing goals, and convincing myself that if I just tried harder, I'd finally feel accomplished. But no matter how much I achieved, something always felt off. I was exhausted, anxious, and constantly pushing for the next thing.In this episode, I share what I've learned since those burnout-fueled days—why trying harder eventually stops working and how your nervous system quietly decides when it's safe to move forward.We'll dive into the real reasons willpower fades, motivation dips, and self-sabotage sneaks in, even when you know what to do. You'll learn my RISE framework—Regulate, Identify, Select, and Encode—so you can start creating change that actually sticks.If you're ready to stop forcing your way forward and start rising with more ease, this conversation will feel like an exhale.

BEHIND THE SCENES STUDIOWork with the same Meta Ads creative production team that Andrew does with Behind The Scenes Studio, a More Staffing sister company: ⁠https://www.behindthescenes.studio/.RICHPANELCut your support costs by 30% and reduce tickets by 30%—guaranteed—with Richpanel's AI-first Customer Service Platform that will reduce costs, improve agent productivity & delight customers at http://www.richpanel.com/partners/ajf?utm_source=youtube.//This episode gets practical about AI and ad creative. Andrew Faris and Alex Cooper (Adcate) break down what's actually working, why most AI ads still fall flat, and how operators can build a creative system that compounds.What you'll learn:- AI as an amplifier, not a shortcut: why bad ideas stay bad, even with great models—and how to surface signal from 20+ AI-generated options instead of shipping noise.- Context engineering OVER prompt engineering: building brand-specific context documents and custom GPT/Claude projects (brand data + top performers + task-specific creative principles) to raise hit rate across headlines, hooks, scripts, and iterations.- Operationalized knowledge: treating your agency/org as “operationalized knowledge,” then encoding that knowledge into AI so strategy scales without diluting quality.- Process over novelty: frameworks like AI Days and moonshot briefs to test new tools (VO3, image/video gen, research apps) without derailing production.- Where VO3 fits now: using intentionally unrealistic visuals for hooks and pattern breaks while keeping workflows realistic for speed and cost.- Tool overload triage: how to evaluate new AI releases against business outcomes (profit, CAC, volume, timelines) and avoid shiny-object churn.- The strategist's new job: knowing what to create (psychology, research, copy fundamentals) while AI accelerates execution.Why this is worth your timeIf you're feeling margin pressure, creative fatigue, or whipsawed by weekly AI launches, this conversation gives you a repeatable way to:- Raise creative hit rate without inflating headcount- Protect focus while still exploring new tools- Encode your best thinking into systems your whole team can useShip more diverse, on-strategy ads—faster//CHAPTER TITLES:00:01:33 - Where Is Alex Moving???00:02:27 - A.I. Great For Ideation, Bad For Execution00:08:24 - Strategy For Deep Research 00:15:15 - The Agency Model In DTC00:22:48 - How To Know What Knowledge Is Truth Using A.I.00:35:48 - The Future Of Content Creation & Creative Output00:41:41 - Andrew's Bet On The Future of A.I. Technology00:45:43 - Hot Takes With Alex//SUBSCRIBE TO MY CHANNEL FOR 2X/WEEKLY UPLOADS!//ADMISSIONGet the best media buying training on the Internet + a free coaching call with Common Thread Collective's media buyers when you sign up for ADmission here: ⁠https://www.youradmission.co/andrew-faris-podcast⁠//FOLLOW UP WITH ANDREW X: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/andrewjfaris ⁠Email: podcast@ajfgrowth.comWork with Andrew: ⁠https://ajfgrowth.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Can New York be the state that shows how to rein in AI before it's too late? State Assemblymember Alex Bores joins Bradley to talk about the Responsible AI Safety and Education (RAISE) Act, a bill he's co-sponsoring to establish safety, audit, and whistleblower guardrails for companies training advanced AI models. Without smart, tough regulation, Bores argues, even well-intentioned tech can be weaponized. From job loss to bioweapons and deepfakes, Bores warns that these problems are not theoretical, they are on our doorstep.New Yorkers: Tell your state legislators to Support the RAISE Act at bit.ly/responsibleAIemailLearn about critical AI safety legislation at the state level endorsed by Encode and Secure AI Project in CA, NY, and IL: bit.ly/supportraiseny This episode was taped at P&T Knitwear at 180 Orchard Street — New York City's only free podcast recording studio.Send us an email with your thoughts on today's episode: info@firewall.media.Subscribe to Bradley's weekly newsletter and follow Bradley on Linkedin + Substack + YouTube.

Encoding brand voice into AI tools requires strategic planning. Nataly Kelly, CMO of Zappi, shares her expertise on maintaining authentic brand identity across AI-generated content. She demonstrates how to document brand values, create comprehensive style guides with specific examples, and train AI tools to recognize your unique writing patterns while maintaining quality through human editing. Show NotesConnect With: Nataly Kelly: Website // LinkedInThe MarTech Podcast: Email // LinkedIn // TwitterBenjamin Shapiro: Website // LinkedIn // TwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Encoding brand voice into AI tools requires strategic planning. Nataly Kelly, CMO of Zappi, shares her expertise on maintaining authentic brand identity across AI-generated content. She demonstrates how to document brand values, create comprehensive style guides with specific examples, and train AI tools to recognize your unique writing patterns while maintaining quality through human editing. Show NotesConnect With: Nataly Kelly: Website // LinkedInThe MarTech Podcast: Email // LinkedIn // TwitterBenjamin Shapiro: Website // LinkedIn // TwitterSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15% of High Schoolers say they know someone in their school who has had deepfake pornography made of them in the last year.In this eye-opening episode, Nicki Reisberg sits down with Adam Billen of Encode to unpack some of the most urgent and unsettling developments in AI—from the rise of chatbots to the explosion of deep fakes. They dive into what Meta is up to with its new chatbot rollout on Instagram, and why that should raise red flags for anyone with kids online. The conversation then turns to deep fakes—how scarily easy they are to make, and the real damage they can cause, especially to children. Nicki and Adam break it all down and call for action—from parents, lawmakers, and schools—to step up and protect the next generation.Watch or listen to Nicki and Adam's first conversation about AI chatbots here.Take it Down Tool by NCMECChild Deepfake Incident Map

This fascinating episode on health and wellness features Michael Snyder, a Professor in Stanford University School of Medicine's Department of Genetics. Michael is widely considered a leader in the field of functional genomics and proteomics – and is a major participant of the ENCODE project. Trained as a microbiologist, Michael is dedicated to gaining a global perspective on health care. Because many aspects of our medical system are broken, he is focused on refining the fields of genomics and proteomics with cutting-edge research. How is technology changing the way we monitor our bodies? Michael sits down to explain… Join the conversation now to find out: Measurements used to indicate when and if someone is getting sick. How your resting heart rate is connected to your immune system. The benefits of using a smartwatch as a health monitor. How monitoring presymptomatic individuals can be used to identify upcoming diseases. You can learn more about Michael and his work by visiting his laboratory website! Episode also available on Apple Podcasts: apple.co/30PvU9C

* Take Me To the Top: Hear Speakers like James Tour, Jerry Bergman, Rob Stadler, Sal Cordova, Joel Brown and our very own Fred Williams Fri & Sat Feb 21 & 22 online at Creation Summit's "No PhD Required" virtual creation conference.    *Dr. Jerry Bergman: Fred Williams and Doug McBurney welcome Dr. Jerry Bergman who has taught biology, genetics, chemistry, biochemistry, anthropology, geology, and microbiology at several Universities for over 40 years. Dr. Bergman is a graduate of Medical College of Ohio, Wayne State University in Detroit, The University of Toledo, and Bowling Green State University.   *Spanking David James: a reference to Real Science Radio was added to professor David James Farina's rationalwiki page because Doug called Professor Dave a communist, (but without reference to our debunking, or even a link)!   *A Heavy Load: And we don't mean Professor Dave's "debunking" of Special Creation! We mean the genetic load of mutations that are overwhelmingly deleterious, and never add information beneficial for the survival of an organism.   *Encode & Haldane's Dilemma: tell us that Professor Dave and his lovely wife would need to bear at least 1048 more children to even have a chance of evolving the species.   *Another Hunk of Junk: turns out to be functioning DNA, and not what Professor Dave and the disciples of Darwin call "Junk DNA".   *All Apologies: Doug apologizes to Professor Dave for making light of his past career difficulties, and extends the gospel to him, knowing that behind the bravado of every atheist is a sad story and a broken heart.   *Mutations, Cancer & Evolution's True Path: Hear the truth about genetic mutations based on Dr. Bergman's decades of research where the evidence proves mutations kill cells, and kill organisms, (and radiation is used to CAUSE mutations to kill cancer cells)!

* Take Me To the Top: Hear Speakers like James Tour, Jerry Bergman, Rob Stadler, Sal Cordova, Joel Brown and our very own Fred Williams Fri & Sat Feb 21 & 22 online at Creation Summit's "No PhD Required" virtual creation conference.    *Dr. Jerry Bergman: Fred Williams and Doug McBurney welcome Dr. Jerry Bergman who has taught biology, genetics, chemistry, biochemistry, anthropology, geology, and microbiology at several Universities for over 40 years. Dr. Bergman is a graduate of Medical College of Ohio, Wayne State University in Detroit, The University of Toledo, and Bowling Green State University.   *Spanking David James: a reference to Real Science Radio was added to professor David James Farina's rationalwiki page because Doug called Professor Dave a communist, (but without reference to our debunking, or even a link)!   *A Heavy Load: And we don't mean Professor Dave's "debunking" of Special Creation! We mean the genetic load of mutations that are overwhelmingly deleterious, and never add information beneficial for the survival of an organism.   *Encode & Haldane's Dilemma: tell us that Professor Dave and his lovely wife would need to bear at least 1048 more children to even have a chance of evolving the species.   *Another Hunk of Junk: turns out to be functioning DNA, and not what Professor Dave and the disciples of Darwin call "Junk DNA".   *All Apologies: Doug apologizes to Professor Dave for making light of his past career difficulties, and extends the gospel to him, knowing that behind the bravado of every atheist is a sad story and a broken heart.   *Mutations, Cancer & Evolution's True Path: Hear the truth about genetic mutations based on Dr. Bergman's decades of research where the evidence proves mutations kill cells, and kill organisms, (and radiation is used to CAUSE mutations to kill cancer cells)!

Summary In this episode of the I Can Do Podcast, host Benjamin Lee engages with Dr. H.E. Buddy Payne, a prominent figure in the discussion of creation and evolution. They explore the rise of atheism, the argument from design, and the complexities of DNA, emphasizing the evidence for intelligent design in the natural world. Dr. Payne shares his personal journey, experiences in presenting scientific evidence, and the significance of the ENCODE project in debunking the myth of junk DNA. The conversation culminates in a call for open-mindedness towards the evidence of a grand designer behind creation. Chapters 00:00 Introduction to the Podcast and Guest 03:19 Dr. Payne's Journey into Creation and Evolution 06:35 The Rise of Atheism and Its Impact 09:25 The Argument from Design 12:18 Experiences Presenting Evidence on College Campuses 15:34 The Importance of Scientific Evidence 18:25 The Complexity of DNA and Intelligent Design 21:12 The Debate on Junk DNA 24:32 The Role of Proteins in DNA Functionality 27:21 Conclusion and Final Thoughts 45:33 The Junk DNA Debate 49:23 The Human Genome Project and Its Implications 55:49 ENCODE: Unraveling the Mysteries of DNA 01:03:21 The Complexity of Gene Expression 01:11:38 The Argument for Intelligent Design 01:21:07 Final Thoughts on Science and Faith 01:27:39 lifestyle-intro-high-short.wav

#2025 #manifesting #intention Access source consciousness through an embodied infinity walk of 8 to call forth into your reality your hearts desire for 2025 working with the electro-magnetic fields of your biofield and the biofield of Gaia Sophia to create and install the codes you require for the most wonderful year ahead.Enjoy!For online courses, in-person retreats and MP3 meditations go to www.sarita-sol.comLIVE WEEKLY ONLINE MEDITATIONS CLASSES WITH ME....JOIN ANYTIMENow available on the Patreon site.https://www.patreon.com/Sarita_Sol/membershipOnce in Patreon join as a 'Light Warrior Patron'website: www.sarita-sol.com

Welcome to the Rose Woman Podcast, where we explore the cutting edge of health, wellness, and personal empowerment. Today, we have a very special guest - Dr. Michael Snyder, a leader in the field of functional genomics and proteomics, and one of the major participants of the ENCODE project.He has also combined different state-of-the-art "omics" technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. Dr. Snyder is the cofounder of Personalis, SensOmics, Qbio @qbioinc, January AI, Filtricine, Mirvie, Protos, Protometrix (now part of Thermo-Fisher). Affomix (now part of Illumina).This is an episode that just might change the way you think about your health and the future of healthcare - don't miss it.In this episode, we cover:Importance of measuring health frequently while people are still healthy to detect early signs of diseaseThe use of wearables, such as smartwatches and Oura rings, plays a crucial role in early detectionBreakdown of omics concepts like genomics, proteomics, and metabolomicsThe role of hormones in aging and the impact of andropause and menopauseEmphasis on the importance of exercise and strength training for overall healthAdvancements in DNA sequencing, mass spectrometry, and wearablesThe importance of continuous data collection and the role of AI in integrating and analyzing large datasetsThe challenges of implementing proactive health monitoring in the current healthcare systemImportance of financial incentives and the role of employers in promoting health and wellnessVision for the future of healthcare with continuous health monitoring and AI-powered personalized recommendationsThe role of hormones and agingHelpful links:Michael Snyder, Ph.D. - Stanford W. Ascherman Professor of Genetics and SnyderlabGenomics and Personalized Medicine: What Everyone Needs to KnowFounder Letter: The New Science on Aging Well by Christine MasonFind Rosebud Woman on Instagram as @rosebudwoman, Christine on Instagram as @christinemariemasonFind Radiant Farms on Instagram @weareradiantfarms Hosted on Acast. See acast.com/privacy for more information.

Today, Calvin Smith of Answers in Genesis Canada, goes through all of the latest evidence for evolution. Either that or he goes through some of the evidence for evolution from the last century...there's a bit of a disconnect between the title and the actual content.Cards:AiG Canada is Lying for Clicks!

We bring you a discussion about the secrets of ancient astronomy with Dr. Duane Hamacher, an Associate Professor of Cultural Astronomy in the School of Physics at the University of Melbourne. Our conversation explores the importance of astronomical observation to ancient people around the world, but particularly those of aboriginal Australia. We ask why so many cultures, geographically isolated, present the same myths for identical constellations. We also explore the migration out of Polynesia and ponder the world during the last ice age. Tell us your thoughts in the comments! Sign up for our Patreon and get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasB AND rock some Demystify Gear to spread the word: https://demystifysci.myspreadshop.com/ OR do your Amazon shopping through this link: https://amzn.to/4g2cPVV (00:00) Go! Exploring the intersection of science and mythology in ancient sky observations (00:07:18) The significance of oral traditions and mythology in preserving ancient knowledge (00:22:02) Myth and mysticism in science and indigenous knowledge (00:23:28 Science as modern mythology (00:26:13) Myth vs mysticism: encoding ancient knowledge (00:29:01) Mythology and empirical myths in science (00:32:59) Evolution of scientific knowledge (00:43:10) Understanding Mythology as Knowledge Transmission (00:46:08) Speculations on Cosmic Events in Mythology (00:49:03) Challenges in Preserving Indigenous Knowledge (00:54:12) Impact of Academic Research on Indigenous Communities (01:04:14) Ancient astronomical predictions and variable stars (01:05:23) Understanding eclipsing binary systems (01:06:20) Ancient Egyptian records and astrophysical insights (01:07:56) Cultural interpretations of celestial events (01:09:19) Oral traditions and eclipse predictions (01:24:42) Ancient cultures' advanced astronomical knowledge (01:28:08) Polynesian migration and cultural astronomy (01:36:03) Underwater archaeology and sea level rise (01:45:29) Celestial Motifs in Global Religions (01:48:17) Venus and Cultural Symbolism (01:49:10) Astronomical Basis of Cultural Rituals (01:54:01) Cross-Cultural Constellations (01:57:03) The Myth of the Seven Sisters (02:05:55) Human Perception of Constellations (02:07:04) Cultural Influence on Constellation Creation (02:25:21) The impact of interdisciplinary collaboration #sciencepodcast, #longformpodcast, #Mythology, #AncientKnowledge, #OralTraditions, #IndigenousWisdom, #CulturalAstronomy, #ScienceAndMyth, #CosmicEvents, #AstronomyHistory, #AncientAstronomy, #PolynesianNavigation, #MythVsMysticism, #AncientEgypt, #CulturalRituals, #VenusSymbolism, #SevenSistersMyth, #CrossCulturalAstronomy, #Constellations, #InterdisciplinaryScience, #UnderwaterArchaeology, #HumanOrigins Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671

Guest: Ziv Williams, Associate Professor in the Department of Neurosurgery at Harvard Medical School.

Alfred Hitchcock's Rear Window with Jimmy Stewart, Grace Kelly, and Raymond Burr! https://archive.org/download/high-noon-1952_202304/REAR%20WINDOW.1954.ia.mp4 Support us on Patreonhttps://www.patreon.com/user?u=4279967Jack Benny TV Videocasthttps://open.spotify.com/show/6BDar4CsgVEyUloEQ8sWpw?si=89123269fe144a10Jack Benny Show OTR Podcast!https://open.spotify.com/show/3UZ6NSEL7RPxOXUoQ4NiDP?si=987ab6e776a7468cJudy Garland and Friends OTR Podcasthttps://open.spotify.com/show/5ZKJYkgHOIjQzZWCt1a1NN?si=538b47b50852483dStrange New Worlds Of Dimension X-1 Podcasthttps://open.spotify.com/show/6hFMGUvEdaYqPBoxy00sOk?si=a37cc300a8e247a1Buck Benny YouTube Channelhttps://r.search.yahoo.com/_ylt=AwrOoc1Q5bllBgQA469XNyoA;_ylu=Y29sbwNncTEEcG9zAzEEdnRpZAMEc2VjA3Ny/RV=2/RE=1707891281/RO=10/RU=https%3a%2f%2fwww.youtube.com%2f%40BuckBenny/RK=2/RS=nVp4LDJhOmL70bh7eeCi6DPNdW4-Support us on Patreonhttps://www.patreon.com/user?u=4279967

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Feature Targeted LLC Estimation Distinguishes SAE Features from Random Directions, published by Lidor Banuel Dabbah on July 19, 2024 on LessWrong. Tl;dr: In this post we present the exploratory phase of a project aiming to study neural networks by applying static LLC estimation to specific alterations of them. We introduce a new method named Feature Targeted (FT) LLC estimation and study its ability to distinguish SAE trained features from random directions. By comparing our method to other possible metrics, we demonstrate that it outperforms all of them but one, which has comparable performance. We discuss possible explanations to our results, our project and other future directions. Introduction Given a neural network M and a latent layer within it, L, a central motif in current mechanistic interpretability research is to find functions f:LR [1] which are features of the model. Features are (generally) expected to exhibit the following properties: 1. Encode interpretable properties of the input. 2. Be causally relevant to the computation of the output of the model. 3. Encode the output of a certain submodule of our model M, i.e. a component, localized in weight space, which is responsible for a specific part of the total computation. While this is common wisdom, methods for automated feature evaluation usually focus on correlations between the (top) activations of the feature with human (or machine) recognizable interpretations, or on the effect of feature-related interventions on the output of the model. In particular, while the first and second items of the feature characterization above are central in current techniques, the third property, specifically the localized nature of the computation upstream of the feature, is less so[2]. We are currently investigating a direction which fills that gap, and this post shares the findings of the exploratory research we have conducted to validate and inform our approach. More specifically, we operationalized the concept of "weight-localized computation" using the local learning coefficient (LLC) introduced in Lau et al, following the learning coefficient first introduced in the context of singular learning theory. We apply LLC estimation to models associated with our base model and a feature within it, a method we call feature targeted (FT) LLC estimation. In this exploratory work we study FT-LLC estimates of specific models associated with SAE features. Most notably, we have found that: 1. FT-LLC estimates of SAE features are, on average, distinguishably higher then those of random directions. 2. For a particular variant of FT-LLC estimation, which we named the functional FT-LLC (defined in this section) this separation is pronounced enough such that the vast majority of SAE features we studied are clearly separated from the random features we studied. Furthermore, most baseline metrics we compared it to (see here) are less capable at distinguishing SAE features from random directions, with only one performing on par with it. Section 1 introduces the main technique we study in this post, FT-LLC estimation, and section 2 outlines our motivations. Section 3 describes the details of our experimental setting, our results, and the comparison to baseline metrics. In section 4 we discuss our overall takes, how they fit within our general agenda and gaps we currently have in theoretically understanding them. Section 5 is devoted to outlining our next steps, the general direction of the project, and some other possible directions for further research. Lastly, we briefly discuss related work in section 6. What is FT-LLC? LLC estimation We start out by briefly recalling what the local learning coefficient (LLC) is. If you are unfamiliar of the term, we recommend reading this, the longer sequence here, or the paper on LLC estimation ...

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Feature Targeted LLC Estimation Distinguishes SAE Features from Random Directions, published by Lidor Banuel Dabbah on July 19, 2024 on The AI Alignment Forum. Tl;dr: In this post we present the exploratory phase of a project aiming to study neural networks by applying static LLC estimation to specific alterations of them. We introduce a new method named Feature Targeted (FT) LLC estimation and study its ability to distinguish SAE trained features from random directions. By comparing our method to other possible metrics, we demonstrate that it outperforms all of them but one, which has comparable performance. We discuss possible explanations to our results, our project and other future directions. Introduction Given a neural network M and a latent layer within it, L, a central motif in current mechanistic interpretability research is to find functions f:LR [1] which are features of the model. Features are (generally) expected to exhibit the following properties: 1. Encode interpretable properties of the input. 2. Be causally relevant to the computation of the output of the model. 3. Encode the output of a certain submodule of our model M, i.e. a component, localized in weight space, which is responsible for a specific part of the total computation. While this is common wisdom, methods for automated feature evaluation usually focus on correlations between the (top) activations of the feature with human (or machine) recognizable interpretations, or on the effect of feature-related interventions on the output of the model. In particular, while the first and second items of the feature characterization above are central in current techniques, the third property, specifically the localized nature of the computation upstream of the feature, is less so[2]. We are currently investigating a direction which fills that gap, and this post shares the findings of the exploratory research we have conducted to validate and inform our approach. More specifically, we operationalized the concept of "weight-localized computation" using the local learning coefficient (LLC) introduced in Lau et al, following the learning coefficient first introduced in the context of singular learning theory. We apply LLC estimation to models associated with our base model and a feature within it, a method we call feature targeted (FT) LLC estimation. In this exploratory work we study FT-LLC estimates of specific models associated with SAE features. Most notably, we have found that: 1. FT-LLC estimates of SAE features are, on average, distinguishably higher then those of random directions. 2. For a particular variant of FT-LLC estimation, which we named the functional FT-LLC (defined in this section) this separation is pronounced enough such that the vast majority of SAE features we studied are clearly separated from the random features we studied. Furthermore, most baseline metrics we compared it to (see here) are less capable at distinguishing SAE features from random directions, with only one performing on par with it. Section 1 introduces the main technique we study in this post, FT-LLC estimation, and section 2 outlines our motivations. Section 3 describes the details of our experimental setting, our results, and the comparison to baseline metrics. In section 4 we discuss our overall takes, how they fit within our general agenda and gaps we currently have in theoretically understanding them. Section 5 is devoted to outlining our next steps, the general direction of the project, and some other possible directions for further research. Lastly, we briefly discuss related work in section 6. What is FT-LLC? LLC estimation We start out by briefly recalling what the local learning coefficient (LLC) is. If you are unfamiliar of the term, we recommend reading this, the longer sequence here, or the paper on LL...

In this episode of the Epigenetics Podcast, we talked with Sarah Marzi from the UK Dementia Research Institute at Imperial College London about her work on epigenetic changes in Alzheimer's Disease, and comparing CUT&Tag to ENCODE ChIP-Seq using limited cell samples. The interview discusses Sarah Marzi's work on ChIP-Seq experiments and their significance in understanding Alzheimer's disease from an epigenetic perspective. The discussion touches on the widespread dysregulation and changes in acetylation, particularly in genes associated with Alzheimer's risk, providing insights into potential links between epigenetic insults and disease onset. Moving on to the technical aspects of the study, the interview examines the strategic use of CUT&Tag. It explores the challenges and optimizations involved in accurately profiling limited cell samples. The dialogue also compares CUT&Tag to ENCODE ChIP-Seq, highlighting the complexities of peak calling and data interpretation across different methodologies.   References Kumsta, R., Marzi, S., Viana, J. et al. Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry 6, e830 (2016). https://doi.org/10.1038/tp.2016.95 Marzi, S. J., Schilder, B. M., Nott, A., Frigerio, C. S., Willaime‐Morawek, S., Bucholc, M., Hanger, D. P., James, C., Lewis, P. A., Lourida, I., Noble, W., Rodriguez‐Algarra, F., Sharif, J., Tsalenchuk, M., Winchester, L. M., Yaman, Ü., Yao, Z., The Deep Dementia Phenotyping (DEMON) Network, Ranson, J. M., & Llewellyn, D. J. (2023). Artificial intelligence for neurodegenerative experimental models. Alzheimer's & Dementia, 19(12), 5970–5987. https://doi.org/10.1002/alz.13479 Marzi, S. J., Leung, S. K., Ribarska, T., Hannon, E., Smith, A. R., Pishva, E., Poschmann, J., Moore, K., Troakes, C., Al-Sarraj, S., Beck, S., Newman, S., Lunnon, K., Schalkwyk, L. C., & Mill, J. (2018). A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience, 21(11), 1618–1627. https://doi.org/10.1038/s41593-018-0253-7 Hu, D., Abbasova, L., Schilder, B. M., Nott, A., Skene, N. G., & Marzi, S. J. (2022). CUT&Tag recovers up to half of ENCODE ChIP-seq peaks in modifications of H3K27 [Preprint]. Genomics. https://doi.org/10.1101/2022.03.30.486382   Related Episodes When is a Peak a Peak? (Claudio Cantù) Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab) DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

For the longest time I thought that you were feeling guilty for prioritizing yourself. Now I understand that you are discouraged that you don't take the time to prioritize yourself, which leads to an endless cycle of discouragement, inaction, and anxiety. Well I have developed the antidote to the Discouragement Cycle that I have been using on both my 1:1 clients and my membership clients. It's called the E3 Method. In this episode, I go through what the E3 Method is and how we can work together with this simple process so that you can get out of your head and start putting you first without getting discouraged and not doing it. And without feeling guilty when you do! Schedule your call today! ⁠Get the Free Self-care App⁠ ⁠⁠Follow on Instagram⁠⁠⁠ ⁠⁠Apply for one-on-one coaching⁠⁠ (Ditch the Guilt: Feel Good about Setting Boundaries and Prioritizing Self-care) Free journaling process: ⁠⁠⁠"Don't Suppress, Process: 3 Steps to Get Out of Your Head"⁠⁠⁠  Watch ⁠⁠⁠"4 Secrets to Managing Your Emotions Without Guilt"⁠⁠⁠ on YouTube ⁠⁠Apply to be on the podcast⁠

Become a supporter of this podcast: https://www.spreaker.com/podcast/viced-rhino-the-podcast--4623273/support.Today, Creation Ministries International Canada (CMI Canada) tries to explain why DNA proves creation...and they seem to have gotten in over their heads.Cards:Critiquing Deflate's Critique of a Religious Critique!:https://youtu.be/cTCYOX4RnIcOriginal Video: http://tinyurl.com/25cc8hqwSources:DNA is life's blueprint? No, there's far more to it than that: http://tinyurl.com/29sytd7pRNA Polymerase and Transcription Mechanisms: The Forefront of Physicochemical Studies of Chemical Reactions: http://tinyurl.com/2824baycLife as a manifestation of the second law of thermodynamics: http://tinyurl.com/2876sudu The Origin of Life: A case is made for the descent of electrons: http://tinyurl.com/y4qa5esaPew Research Center's 2014 Survey of AAAS Members: http://tinyurl.com/24zzsyud On the Origin of Species: http://tinyurl.com/2a95jcwpInventing the dynamo machine: the evolution of the F-type and V-type ATPases: http://tinyurl.com/23lk6px5 The Ancestral Shape of the Access Proton Path of Mitochondrial ATP Synthases Revealed by a Split Subunit-a: http://tinyurl.com/297h7od3ATP synthases from archaea: The beauty of a molecular motor: http://tinyurl.com/299cxoceThe evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio: http://tinyurl.com/299cxoceATP synthase: Evolution, energetics, and membrane interactions: http://tinyurl.com/2dhkofl2ATP synthases: structure, function and evolution of unique energy converters: http://tinyurl.com/23ujjohxThe progenitor of ATP synthases was closely related to the current vacuolar H+-ATPase: http://tinyurl.com/2cd4ptgdStepwise formation of the bacterial flagellar system: http://tinyurl.com/26j7wyejA reducibly complex mousetrap: http://tinyurl.com/2b8oz478Mitochondrial ATP synthase: architecture, function and pathology: http://tinyurl.com/2d3729ug Droplets: Unconventional Protocell Model with Life-Like Dynamics and Room to Grow: http://tinyurl.com/24f4tmoe Reading and writing single-atom magnets: http://tinyurl.com/24tk7qceSpontaneous formation and base pairing of plausible prebiotic nucleotides in water: http://tinyurl.com/2c2n655rIdentifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites: http://tinyurl.com/yyqbrajwNucleobase synthesis in interstellar ices: http://tinyurl.com/25pththmSynthetic Life with Alternative Nucleic Acids as Genetic Materials: http://tinyurl.com/27lj75h4 Origin and evolution of the genetic code: the universal enigma: http://tinyurl.com/y2e3e25xA Production of Amino Acids Under Possible Primitive Earth Conditions: http://tinyurl.com/28lz85c8A search for tryptophan in the gas of the IC 348 star cluster of the Perseus molecular cloud: http://tinyurl.com/2xmg67ysAmino acids in meteorites: http://tinyurl.com/2bvbjppmMiller–Urey experiment (Wikipedia): http://tinyurl.com/7hngnybAsymmetric autocatalysis. Chiral symmetry breaking and the origins of homochirality of organic molecules: http://tinyurl.com/2ypr22myIntelligent Design Is Not Creationism: http://tinyurl.com/28rwc67kThe Cost Of Natural Selection: https://tinyurl.com/2xr7pgy4Evolutionary Rate at the Molecular Level: https://tinyurl.com/2caxvttyAn Upper Limit on the Functional Fraction of the Human Genome: https://tinyurl.com/2cp73d77Low Fertility in Evolutionary Perspective: https://tinyurl.com/2c32ox8vWhy do humans have an Appendix?: https://tinyurl.com/2gcyaxhqConceptual and Empirical Challenges of Ascribing Functions to Transposable Elements: https://tinyurl.com/2cbvs8f7On the Immortality of Television Sets: "Function" in the Human Genome According to the Evolution-Free Gospel of ENCODE: https://tinyurl.com/y7wvwdvpComparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks: https://tinyurl.com/27fpj2okAll my various links can be found here:http://links.vicedrhino.com

Today I had the pleasure of interviewing Emily Surdyke. She is a Coach, Healing Guide, and Nuroencoding Specialist. Key Takeaways- Neuroencoding - is rewiring your past beliefs. It is a daily practice of reprograming your beliefs and thoughts - Journal is a tool they use - to encode your dream life - So it is daily brainwashing yourself to become the healthier happier version of yourself - The Stop Technique - to help with anxiety to rewire your nervous system -Movement is key - to help you change your state and get into a higher state -The importance of getting in your body and out of your head -Keep going, and believe in yourself - you are so worthy of healing and having a life you adore. Emily's Links Instagram - https://www.instagram.com/ignitedpresence?igsh=MWh4YzlnMDhpZ2M3cA%3D%3D Facebook - https://www.facebook.com/Ignitedpresencewithemily?mibextid=ZbWKwL Link for more information on neuroencoding - https://www.neuroencoding.com/?sc_ref=3OGWGnjOsUtsFTjs My links- Instagram - https://www.instagram.com/haley.helveston/ Email - helvestonhaley@gmail.com

This fascinating episode on health and wellness features Michael Snyder, a Professor in Stanford University School of Medicine's Department of Genetics. Michael is widely considered a leader in the field of functional genomics and proteomics – and is a major participant of the ENCODE project. Trained as a microbiologist, Michael is dedicated to gaining a global perspective on health care. Because many aspects of our medical system are broken, he is focused on refining the fields of genomics and proteomics with cutting-edge research. How is technology changing the way we monitor our bodies? Michael sits down to explain… Join the conversation now to find out: Measurements used to indicate when and if someone is getting sick. How your resting heart rate is connected to your immune system.  The benefits of using a smartwatch as a health monitor.  How monitoring presymptomatic individuals can be used to identify upcoming diseases. You can learn more about Michael and his work by visiting his laboratory website! Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: apple.co/30PvU9C

JAN - 03 - 2024 W.L.U.M LIVE AT (MIAMI ENCODE RADIO) 10 HOURS ON AIR CELEBRATING CHINO BIRTHDAY ///////////////////////// NAPP - 4PM FEDE BARGA - 6PM EL CHINO DREADLION - 8PM DJ CARLOS G - 10PM DJ ROBERTO TORRES - 12AM ///////////////////////// #WELOVEUNDERGROUNDMUSIC #MIAMIENCODERADIO #NAPP #FEDEBARGA #ELCHINODREADLION #DJCARLOSG #DJROBERTOTORRE #justfeelthebeat #partytime #partypeople #housemusicallmorning #tribal #techno #techhouse #afrohouse #nativeinstruments #traktordj #residentdj #djlife

JAN - 03 - 2024 W.L.U.M LIVE AT (MIAMI ENCODE RADIO) 10 HOURS ON AIR CELEBRATING CHINO BIRTHDAY ///////////////////////// NAPP - 4PM FEDE BARGA - 6PM EL CHINO DREADLION - 8PM DJ CARLOS G - 10PM DJ ROBERTO TORRES - 12AM ///////////////////////// #WELOVEUNDERGROUNDMUSIC #MIAMIENCODERADIO #NAPP #FEDEBARGA #ELCHINODREADLION #DJCARLOSG #DJROBERTOTORRE #justfeelthebeat #partytime #partypeople #housemusicallmorning #tribal #techno #techhouse #afrohouse #nativeinstruments #traktordj #residentdj #djlife

The secret of mastery (arguably) lives in a single word. Minimalism. I've been teaching this for over two decades. Saying that “minimalism isn't just a design vibe. It's a lifestyle.” Encouraging human beings in fiery pursuit of their private Mount Everests to do less to achieve more.Imagine getting genius at saying no to most opportunities so you say yes to the few that you can execute at peak on?­Imagine making products and generating outputs that are gaspworthy because of what you've had the bravery to leave out. Rather than put on. [Thanks Steve Jobs and Jony Ive]. Yes. Go for minimalism. Reject maximalism. And own your domain.If you'd like to learn the tools, habits and daily routines of warriors, billionaires, sages and superstars then read (or listen to) The Everyday Hero Manifesto today. It's a life-changing book. Get it here.FOLLOW ROBIN SHARMA:InstagramFacebookTwitterYouTube

This week on Drumcode Radio we have a mix from Victor Ruiz, recorded at Encode in Las Vegas, USA.

Level Lock+ and Schlage Encode Plus Review   In this episode Craig and Kevin review two smart locks – the Level Lock+ and the Schlage Encode Plus. If you've ever considered purchasing a smart lock, you need to give these two products a look. The cool thing about the Level Lock+ is that it looks exactly like a traditional deadbolt but has the full functionality of a smart lock. This episode lines out the pros and cons of each. We also have some banter about sports and discuss some interesting real estate facts.   Level Lock+ Schlage Encode Plus   Buy a Homeowners Show T-Shirt!   Subscribe to our YouTube Channel   The Homeowners Show Website The Homeowners Show Facebook Page Instagram @homeownersshow Twitter @HomeownersThe   Info@homeownersshow.com    Sustained Growth Solutions – Design a lead generation system specifically for your business so that you never have to search for leads again! We are a full digital marketing agency.   Termisave Email – Warranty your home against the threat of termites. 

Tycoons are unbreakable optimists. They value a better world because of their innovations and hope for a richer future because of their inventions. They are masters of entrepreneurship instead of entitlement, really believing that their creativity, productivity, teamwork and contributions to their industry are exponentially more essential to their success than having a fortunate destiny or getting lucky.If you'd like so much more information like this to keep you focused on your mission in these trying times along with science-backed insights and daily practices to increase your happiness, performance and peacefulness......Go ahead and read my latest book The Everyday Hero Manifesto. It's become a worldwide phenomenon because it works. Period.FOLLOW ROBIN SHARMA:InstagramFacebookTwitterYouTube

This week Fred and Doug welcome scientist and creation researcher Sal Cordova, a bio-molecular physics researcher. He has published with the Federation of American Societies for Experimental Biology, Springer/Nature, Oxford University Press, and Creation Research Society Quarterly. His Christian testimony, life story, and advocacy of Intelligent Design (ID) appeared in the journal Nature. He was featured on national TV, radio, magazines and in the 2008 motion picture "Expelled". He presently holds five degrees: an MS in Applied Physics from Johns Hopkins, a BS in Computer Science, BS Electrical Engineering with a minor in Music, BS in Mathematics with a minor in Physics, an unaccredited MS equivalent in Biology. Sal is presently preparing to enter a doctoral program in Engineering, and graduated Dulles Aviation flight school.  He was a senior engineer and scientist in the aerospace and defense industry at MITRE (Massachusetts Institute of Technology, Research and Engineering) and Army Night Vision Labs. He worked for Cornell genetic engineer John C. Sanford in areas of population genetics and protein biology.   Engineering Biology: 1/3 of engineers are graduating into careers in biology because the skill set fits the necessary analysis of God's amazing engineering.   Evolution Fairy Tale: See the website that helped Sal Cordova realize that the story of evolution was never even fit for children's story time.   Trading Genesis: Sal laments the state of Cristian Academia regarding creation and real science.   Survival of the Sickest? Find out how some of the greatest minds in medicine are left explaining that humanity needs disease.   Encode Ends Evolution: Hear Sal's insights on the ongoing destruction of evolutionary theory being wrought by the ENCODE project.   The Eye of the Beholder: Sal and Fred connect information science, engineering and genetic dots describing, (for example) the incredible design of the human eye.   Redefining Fitness: Hear how the publications of leading evolutionary biologists prove their uselessness to anything save further documenting the absurdity of their field.   Alu, Transcriptones, and the End of the Argument: While evolutionary biologists tend to view genetic hardware and data as junk, engineers see it for what it is - memory storage units and computer code!  

This week Fred and Doug welcome scientist and creation researcher Sal Cordova, a bio-molecular physics researcher. He has published with the Federation of American Societies for Experimental Biology, Springer/Nature, Oxford University Press, and Creation Research Society Quarterly. His Christian testimony, life story, and advocacy of Intelligent Design (ID) appeared in the journal Nature. He was featured on national TV, radio, magazines and in the 2008 motion picture "Expelled". He presently holds five degrees: an MS in Applied Physics from Johns Hopkins, a BS in Computer Science, BS Electrical Engineering with a minor in Music, BS in Mathematics with a minor in Physics, an unaccredited MS equivalent in Biology. Sal is presently preparing to enter a doctoral program in Engineering, and graduated Dulles Aviation flight school.  He was a senior engineer and scientist in the aerospace and defense industry at MITRE (Massachusetts Institute of Technology, Research and Engineering) and Army Night Vision Labs. He worked for Cornell genetic engineer John C. Sanford in areas of population genetics and protein biology.   Engineering Biology: 1/3 of engineers are graduating into careers in biology because the skill set fits the necessary analysis of God's amazing engineering.   Evolution Fairy Tale: See the website that helped Sal Cordova realize that the story of evolution was never even fit for children's story time.   Trading Genesis: Sal laments the state of Cristian Academia regarding creation and real science.   Survival of the Sickest? Find out how some of the greatest minds in medicine are left explaining that humanity needs disease.   Encode Ends Evolution: Hear Sal's insights on the ongoing destruction of evolutionary theory being wrought by the ENCODE project.   The Eye of the Beholder: Sal and Fred connect information science, engineering and genetic dots describing, (for example) the incredible design of the human eye.   Redefining Fitness: Hear how the publications of leading evolutionary biologists prove their uselessness to anything save further documenting the absurdity of their field.   Alu, Transcriptones, and the End of the Argument: While evolutionary biologists tend to view genetic hardware and data as junk, engineers see it for what it is - memory storage units and computer code!  

Too many good souls among us are sloppy with their vocabulary. Speaking of negativity and difficulty in a world filled with overwhelming opportunity, for those with the eyes/perception/wisdom to see it.So stand true to your right to be great. And talk like the leader, visionary and possibilitarian you are.It won't be easy (world-class never is). It will, however, be worth it.If you'd like to learn the tools, habits and daily routines of warriors, billionaires, sages and superstars then read (or listen to) The Everyday Hero Manifesto today. It's a life-changing book. Get it here.FOLLOW ROBIN SHARMA:InstagramFacebookTwitterYouTube