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Genetic screening is recommended when a specific cancer appears to run in a family. BRCA and Lynch syndrome are two conditions, that when inherited, predispose someone to developing a number of different cancers. BRCA 1 and BRCA 2 are tumour suppressor genes. When they function normally they stop cells in the breast, ovary and other tissues from dividing too rapidly and also repair errors that happen when cells do divide. Mutations in these genes result in a higher risk of developing cancer of ovary and breast. Lynch syndrome predisposes to a number of cancers - most commonly colon, uterine and ovarian cancer. Lynch syndrome arises due to errors in a process called mismatch repair. Mismatch repair is a process of DNA repair that typically involves four different genes.
Dr. Bill Kerr, Co-Founder and CEO of Avalon Healthcare Solutions, sheds light on the value of genetic data and is focused on getting the science of gene sequencing better understood. Genetic testing can identify opportunities for treatment and specific mutations that can lead to a more precise therapy. With the abundance of genetic tests available, interpreting the results correctly is the challenge. Bill elaborates, "Our job is to get the science of lab testing adopted in the industry. We have done that by working with health plans that have to adopt coverage for the testing, to be paid for the labs that perform the testing, and then the physician experts who either define the testing when it's useful or who are ordering the testing. We live in an ecosystem where we work with all those parties to ensure that good genetic testing is adopted, that the results are understood, and that they are acted upon appropriately." "The real issue is understanding when a test can be useful to a patient and a doctor. Just because we can sequence DNA doesn't mean we understand what it means or what to do about it. I would suggest to you that one of the reasons we have heard the phrase precision medicine for so long but have not seen as much of that get adopted is we haven't understood the link between what we see in the DNA and what we know to do about it. I'll give you a couple of examples." "One, cancer. Cancer has been an area where we have, for some time, understood that certain genetic predispositions or even mutations can drive cancer or suggest that cancer could be worse. We have just recently had therapies that target those mutations. Now, we've got several great therapies that are tied to that. Previously, just doing the analysis may have had no real benefit to the patient or maybe later had some prognostic capability, but now actually has therapeutic relevance. That's been very important." #AvalonHealthcare #AvalonHCS #GeneticTesting #GeneticTests #LabTests #LabTesting #ClinicalTesting #ClinicalTests #MedicalTests avalonhcs.com Download the transcript here
Dr. Bill Kerr, Co-Founder and CEO of Avalon Healthcare Solutions, sheds light on the value of genetic data and is focused on getting the science of gene sequencing better understood. Genetic testing can identify opportunities for treatment and specific mutations that can lead to a more precise therapy. With the abundance of genetic tests available, interpreting the results correctly is the challenge. Bill elaborates, "Our job is to get the science of lab testing adopted in the industry. We have done that by working with health plans that have to adopt coverage for the testing, to be paid for the labs that perform the testing, and then the physician experts who either define the testing when it's useful or who are ordering the testing. We live in an ecosystem where we work with all those parties to ensure that good genetic testing is adopted, that the results are understood, and that they are acted upon appropriately." "The real issue is understanding when a test can be useful to a patient and a doctor. Just because we can sequence DNA doesn't mean we understand what it means or what to do about it. I would suggest to you that one of the reasons we have heard the phrase precision medicine for so long but have not seen as much of that get adopted is we haven't understood the link between what we see in the DNA and what we know to do about it. I'll give you a couple of examples." "One, cancer. Cancer has been an area where we have, for some time, understood that certain genetic predispositions or even mutations can drive cancer or suggest that cancer could be worse. We have just recently had therapies that target those mutations. Now, we've got several great therapies that are tied to that. Previously, just doing the analysis may have had no real benefit to the patient or maybe later had some prognostic capability, but now actually has therapeutic relevance. That's been very important." #AvalonHealthcare #AvalonHCS #GeneticTesting #GeneticTests #LabTests #LabTesting #ClinicalTesting #ClinicalTests #MedicalTests avalonhcs.com Listen to the podcast here
Wayne Adam Ford, was famously referred to by many following his shocking confession as the "serial killer with a conscience.” Is a man like Wayne who has committed such heinous crimes capable of remorse? You be the judge. This is a tale woven with peculiar family dynamics, traumatic incidents, and unfortunately, murder. Brace yourself, and make no mistake, his deeds were just as horrific as any other convicted killer.Wayne's childhood was a time marred by a father's strict discipline and a mother's adherence to a complacent domestic life. Picture a young boy, navigating through a tumultuous family life, and making sense of a world where love was replaced with rigidity and resentment. Fast forward to his young adulthood, where a life-altering accident leaves Wayne critically injured and with a personality shift that no one could ignore. As we explore his eerie trajectory, we also delve into the dark side of Wayne's romantic relationships, shedding light on a disturbing pattern of abuse and control. Of course, as always, we wrap this one up by reflecting on any insight we can glean from our tarot reading because viewing the world through a mystical lens can often help us to process our thoughts and feelings, even with a case this dark. Do the cards provide us with any insight into the case or the backstory of anyone involved? And lastly, did Wayne Adam Ford, a man infamous for his violent crimes, really have a conscience? This is one episode that may just haunt you long after it's over.This week we shared a promo for Live, Laugh, Murder! --------- EPISODE KEYWORDS ---------Serial Killer, Wayne Adam Ford, Conscience, Family Dynamics, Traumatic Incidents, Inner Demons, Childhood, Strict Discipline, Domestic Life, Turbulent Family Life, Life-Altering Accident, Personality Shift, Marital Abuse, Pattern of Abuse, Tarot Readings, Psychic Insights, Victim Blaming, Violence Against Women, Card Readings, Consequences of ActionsIf you're enjoying our podcast, please consider leaving a rating & review on Apple Podcasts. It helps get us seen by more creepy people just like you! Stay connected with us for more creepy content. Visit our website! Find us on Facebook, Instagram, TikTok, Patreon, & more! If you have any true crime, paranormal, or witchy stories you'd like to share with us & possibly have them read (out loud) on an episode, email us at pnwhauntsandhomicides@gmail.com or use this link. There are so many ways that you can support the show: BuyMeACoffee, Apple Podcasts or by leaving a rating & review on Apple Podcasts. Pastebin: for sources.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5955451/advertisement
Listen to Rabbi Aaron Potek's 5784 Erev Rosh Hashanah sermon from Friday, September 15, 2023 on identity and what it means to choose Judaism.
Discussed natural selection and our role in it. --- Support this podcast: https://podcasters.spotify.com/pod/show/KL-RollerAgenda.com/support
Dr. Susan and Dr. Jolle discuss some common abnormalities that you can observe in the most populare cat breeds. From polycystic kidne disease to ear and tail abnormalities. The main disadvantage of inbreeding is that these diseases tend to pop up.
There are a lot of services or products out there that afford dog owners to learn more about their dogs than ever before. One of those services or products is genetic testing. We are all familiar with some of the benefits for breeders to do genetic testing but is there any benefit to individual owners doing the testing? Im joined with Caitlin Swingley and Dr. Bob Westra from Neogen to discuss why someone might be interested in their products. Types of products | Pawprint Genetics (Breed Specific) & Canine Health Check (Health Screening) The Canine Healthcheck screening process Lucy is a carrier of the HUU! Whats that mean? Using the results to match a potential breeding What kind of impact do we see from genetic mutation? Genetic testing to try and better each breed Benefits of genetic testing for our veterinary work ups "Poligenetic" concerns Working with specific breed clubs Breed identification testing Phenogenetic AND genetic testing should be part of a breeder's due dilligence Test pricing Common issues within popular breeds -- NEOGEN PROMO CODES: Paw Print Genetics | GDIY23 for 25% off your order Canine Health Check | GDIYCHC for $40 off -- Presented By: Standing Stone Supply [Use Code: GDIY to save 15%] onX Hunt Maps [Use Code: GDIY20 to save 20%] DT Systems [Use Code: DTSocialMedia15 for 15%] Final Rise Upland Gun Company - Other Partners: Eukanuba // Bird Dog Society - GDIY Links: Patreon // Instagram // Facebook // Website Learn more about your ad choices. Visit megaphone.fm/adchoices
This episode is brought to you by BiOptimizers, Joovv, and Rupa Health.Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Joel Kahn to discuss the different screening tests and biomarkers that can paint a clearer picture of heart health. Dr. Joel Kahn is a practicing cardiologist and a clinical professor of medicine at Wayne State University School of Medicine. He's triple-board-certified in internal medicine, cardiovascular medicine, and interventional cardiology.In this episode, Dhru and Dr. Kahn dive into (audio version / Apple Subscriber version):-How to truly know if your heart is healthy (2:16 / 2:16)-The various blood and metabolic biomarkers for testing cardiac function (4:00 / 4:00)-The Cleerly scan for measuring soft plaque (17:47 / 15:16)-Dr. Kahn's recommendations for HIIT and resistance training (25:15 / 22:33)-Lifestyle tips for reducing soft plaque build-up (34:20 / 30:24)-Endothelial health, nitric oxide production, and the risk for heart disease (40:50 / 36:51)-What specific biomarkers can tell us about heart disease risk and the role of personalized medicine for effective treatment interventions (45:36 / 41:39)-Supplements to aid in lowering soft plaque levels (53:57 / 50:00)-Genetic testing for assessing heart disease risk (1:02:46 / 58:48)-Dr. Kahn's thoughts on dietary protein and resistance training for longevity (1:15:31 / 1:11:58)-What Dr. Kahn does daily to support his longevity (1:31:30 / 1:28:00)Also mentioned in this episode:-Kahn Center for Cardiac Longevity-Heart Doc VIP Dr. Joel Kahn's podcast-What Do I Do With My High Coronary Calcium CT Results: A Guide-HIIT Training Improves Soft Plaque (study)-Try This: VO2 Max as the Best Predictor of Longevity-GB Insight Genetic Testing and Analysis-Maxi Health Kyolic 400 Aged Garlic Extract -Gotu Kola and Pycnogenol French Maritime Pine Bark ExtractsBiOptimizers is offering 10% off plus a special gift with purchase. Just head over to magbreakthrough.com/dhru with code DHRU10.Right now, Joovv is giving my listeners an exclusive offer on your first order. Head over to Joovv.com/dhru and apply my code DHRU.Access more than 3,000 specialty lab tests with Rupa Health. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com today. Hosted on Acast. See acast.com/privacy for more information.
Today's podcast episode is all about the four things you can learn from your IVF cycle. 1. Quality of Your Eggs 2. Fertilization: ICSI, PICSI, and Insemination You'll also learn about how many of your eggs are mature, and your rate of fertilization. 3. Embryo development and progression 4. Genetic testing Read the full show notes for this episode, and find out more about each step on Dr. Aimee's website. Would you like to learn more about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, September 25, 2023 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom. Subscribe to my YouTube channel for more fertility tips! Join Egg Whisperer School Checkout the podcast Subscribe to the newsletter to get updates Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.
The Quest for Genetic Improvement Top shelf genetics put Oakfield Corners Dairy on the map. A robust ET and IVF program yields 7,500 to 8,000 embryos each year. Jonathan Lamb, joins us on The Dairy Show to discuss how genomics, index formulas and phenotypic data factor into matings that win in the showring and have worldwide appeal. In addition to managing more than 10,000 Holsteins in four facilities (three in New York and one in Ohio), Jonathan currently serves as President of Holstein Association USA and offers a producer's perspective on the Council on Dairy Cattle Breeding Board of Directors, where he represents the Purebred Dairy Cattle Association. This episode sponsored by the Council on Dairy Cattle Breeding.
From crops that grow faster to rice that could stop children going blind - the world is full of genetically modified products waiting to come onto the market. Genetic modification techniques in plants have huge problem-solving potential, but are often clouded in controversy. Most scientists say GM food is safe, yet some consumers and environmental campaigners remain unconvinced. This week we look at the potential, and the controversy, in this futuristic field. Presenter: Myra Anubi Reporter: Lizzy McNeill Series producer: Tom Colls Sound mix: Annie Gardiner Editor: Penny Murphy Email: peoplefixingtheworld@bbc.co.uk Image: Illustration of a strand of DNA (Getty Images)
To discover the whole episode type " #344 - Robert Plomin - Psychologist & Geneticist - What if your DNA could predict your future? " on your listening platform.
If you could edit your DNA, would you (or should you)? This question used to be the stuff of science fiction, but no longer. Genetic engineering is here. Dr. Jeff Hardin is a genetic engineer. We chat with him about where the science of genetic engineering is right now. What are the positives? What are the dangers? Should we concerned about the pairing of radical individualism and the increasing availability of this technology? (The conversation starts at 10:25) PLUS, in “Headlines” (1:20), Dr. Anna Daub talks with Dr. Ken Keathley about the ‘Barbie' movie. How does the gospel answer the questions it raises? And in “On My Bookshelf” (30:55), Dr. Daub recommends a book she's reading right now. Visit our website: https://cfc.sebts.edu/ Support the work of the Center: https://cfc.sebts.edu/about/give/ All opinions and views expressed by guest speakers are solely their own. They do not speak for nor represent SEBTS. Read our expressed views and confessions: https://www.sebts.edu/about/what_we_believe.aspx
How can we understand the role of genetic variations in cancer development and treatment? This is one of the most challenging and important questions in modern biology and medicine. A new editorial paper, by researchers Jun S. Song and Mohith Manjunath from the University of Illinois at Urbana-Champaign, offers a novel discussion involving computational methods to address this question. On August 30, 2023, their editorial was published in Oncotarget, entitled, "Predicting the molecular functions of regulatory genetic variants associated with cancer." In this editorial, the authors review recent advances and challenges in identifying and characterizing the functional effects of genetic variants that affect gene regulation, such as enhancers, promoters, and transcription factors. These variants, also known as expression quantitative trait loci (eQTLs), can modulate the expression levels of genes and influence various cellular processes and phenotypes, including cancer susceptibility and response to therapy. The authors propose a framework for predicting the molecular functions of eQTLs based on their genomic context, epigenetic marks, chromatin accessibility, and three-dimensional interactions. They also discuss how to integrate multiple types of data and methods to improve the accuracy and interpretability of the predictions. Furthermore, they highlight the potential applications and implications of their approach for cancer research and precision medicine. “A promising approach to address these challenges is to integrate genomic, epigenomic, transcriptomic and machine learning methods to identify functional genetic variants and characterize their mode of action in regulating target genes.” Full blog - https://www.oncotarget.org/2023/09/07/predicting-functions-of-cancer-associated-genetic-variants/ Editorial DOI - https://doi.org/10.18632/oncotarget.28451 Correspondence to - Jun S. Song - songj@illinois.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28451 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, genome-wide association studies, cancer risk, regulatory variants, functional genomics About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Labor of Love: A Podcast for BIPOC Adoptees Navigating Parenthood
Join us for a beautiful conversation with adoptee mother, Astrid Castro and daughter, Maya Papaya Castro Dabbeni. They generously share about their tremendous love and bond, and shed light on how intergenerational trauma and painful legacies of adoption have affected their relationship, perspectives, and behaviors. We also discuss the importance of mirroring and how unique it is for adoptees and children of adoptees; their unique birth family reunion story; birth language acquisition within adoptee families; creating adoption fluency; and moving from isolation as adoptees into community together with our children. https://www.adoptionmosaic.com/Astrid Castro BioAstrid Castro (she/her/hers) is the founder and CEO of Adoption Mosaic. Adoption Mosaic is a BIPOC adoptee, woman-led business that seeks to build an inviting adoption conscious community by providing innovative adoptee-centered programs and support.Including a monthly virtual panel series called We the Experts: Adoptee Speaker Series. Astrid has a degree in sociology with an emphasis in adoption. For twenty plus years, she has traveled the country to lead youth groups, present workshops on transracial parenting, talking with children about adoption, and various other workshops focusing on adoption. Prior to creating Adoption Mosaic, Astrid worked in both the private and public sectors of various adoption organizations such as the Oregon Post Adoption Resource Center (ORPARC), Holt International and Rocky Mountain Adoption Exchange.Astrid co-authored Adoption in the Movies, which takes the reader on a guided tour of 27 movies and documentaries that are ‘dripping with adoption' which are asking questions that encourage viewers to engage in ongoing dialogue and discussion. She also developed an innovative, evidence-based, 27-minute training DVD titled, Adoptive Parent Training:Developing Communication Skills. The training demonstrates how adoptive parents can communicate openly and honestly with family, friends and especially children. Astrid is a former member of the board of directors of the North American Council on Adoptable Children, the author of many articles on the subject of adoption and contributed a chapter to the book Parenting as Adoptees. Astrid's personal experiences as an adoptee, a woman of color, and growing up in a white family and community, fuel her professional path to helping others. Astrid is aware of the benefit of post-adoption services for individuals and their families and seeks to bring these services to the adoption community. Her life-long interest in adoption is rooted in her own adoption at the age of four from Colombia (along with her older sister). Astrid has been in reunion with her birth family in Colombia since December 2011. Read about Astrid's journey of searching and finding her birth mother in The Oregonian. When Astrid is not working she loves to spend time with family, friends and enjoying the adventures of life as the mama of an amazing daughter.Maya Papaya Castro Dabbeni BioMaya has grown up hearing and talking about adoption as a child of an adoptee. She is biracial, Colombian and Italian, as well as trilingual, Italian, Spanish and English. At a young age, Maya was a driving force in finding her maternal birth family. To this day, she is still uncovering connections to her Colombian roots, in addition to exploring how generational trauma and epigenetics affect children of adoptees. Maya is excited to share her experience of being a "child of an adoptee" and to bring this topic to light. Maya is currently a third year student at San Jose State University majoring in International Business with a double minor in Spanish and Italian.Co-Hosts: Nari Baker & Robyn ParkMusic: Mike Marlatt & Paul GulledgeEditing: Federico aka mixinghacksArtwork: Dalhe KimListen on: iTunes & SpotifyInstagram: @laboroflovepodcastVenmo: @laboroflovepodcast
After a VERY long break for the Temporal Trek, we are back with Attack of the Cloned Lords of the Flying in Space Poorly Dressed, Faggin's Street Urchin Augments!Three episodes sandwiched together as the Temporal Trek way of watching the show demands it, and actually it might be for the best.Genetic manipulation, medical ethics, morality of science... all of these topics are not discussed in any great depth. What we get is Beautiful people in string vests.Dan and Dan are back, but after this will they want to continue?
Today, you'll learn about gene therapy eye drops, a diamond's journey to the surface, and the growing creativity of AI.Genetic Eye Drops“Gene-therapy drops restore teen's vision after genetic disease left his eyes clouded with scars.” by Nicoletta Lanese. 2023. https://www.livescience.com/health/genetics/gene-therapy-drops-restore-teens-vision-after-genetic-disease-left-his-eyes-clouded-with-scars“Gene therapy eyedrops restored a boy's sight. Similar treatments could help millions.” by Laura Ungar and Freida Frisary. 2023. https://apnews.com/article/gene-therapy-blindness-rare-diseases-58f81838894dfb8568affde0b7e4d2f1“Dystrophic Epidermolysis Bullosa.” by Ellen G Pfendner, PhD & Anne W Lucky, MD. 2018. https://www.ncbi.nlm.nih.gov/books/NBK1304/Kimberlite Explosion “When Ancient Eruptions Pumped Diamonds to Earth's Surface.” by Maya Wei-Haas. 2023. https://www.nytimes.com/2023/07/26/science/kimberlite-diamonds-volcano-eruptions.html?smtyp=cur&smid=tw-nytimesscience“Rift-induced disruptions of cratonic keels drives kimberlite volcanism.” by Thomas M. Gernon, et al. 2023. https://www.nature.com/articles/s41586-023-06193-3“What are Kimberlites?” Kansas Geological Survey. 2000. https://www.kgs.ku.edu/Publications/pic16/pic16_2.htmlCreative Bots “AI tests into top 1% for original creative thinking.” The University of Montana. 2023. https://www.sciencedaily.com/releases/2023/07/230705154051.htm“The Turing Test and AI Large Language Models (LLMs).” by “Mike.” 2023. https://microrealestate.leptonic.io/the-turing-test-and-ai-large-language-models-llms/“8 Potentially Surprising Things To Know About Large Language Models LLMs.” by Dhanshree Shripad Shenwai. 2023. Hosted on Acast. See acast.com/privacy for more information.
This week on ReInvent Healthcare, I go in-depth on genetic markers that relate to inflammation and autoimmune conditions. I also go over certain lab tests that can be done in order to discover which genes are expressing as well as things that can be done so that our clients can get the proper care and support they need. IN THIS EPISODE:The Relationship Between Genetic Markers and InflammationIt is important to understand genetic markers that predispose our clients to inflammation and autoimmune conditions. Being able to recognize and understand these genetic tendencies and how they can be linked to various health issues, including autoimmune diseases and gluten intolerance can give you a better understanding of how to better help your clients so you can guide them with the proper diet, lifestyle, and nutrients that they need.The Role of Lab Testing in Identifying Inflammatory MarkersDoing the proper lab tests and checking for significant markers including Highly sensitive C-reactive protein (HS-CRP), erythrocyte sedimentation rate (ESR), and homocysteine, in assessing inflammation levels is highly important. These tests provide valuable information for identifying inflammation and potential underlying causes, such as nutrient deficiencies and fatty acid imbalances.Motivating Clients to Make Lifestyle ChangesKnowing about our clients' genetic markers, lab results, and what they are predisposed to should help us be able to motivate our clients to make necessary lifestyle changes. By educating clients about their genetic predispositions and showing them tangible evidence through testing, we can empower them to take proactive steps to improve their health, such as adopting specific dietary changes and managing stress levels.ReInvent Healthcare LinksGet our FREE Guide to Taking a Detailed Health History that gets you to root causes.Access Additional Resources for Practitioners ready to improve clinical outcomes through our Nutritional Endocrinology Practitioner Training. Visit my ReInvent Healthcare site to check out other episodes that will be beneficial to you and your clients. Visit this link to check my free Immune Guide. Check out my other episodes on Functional Immunology here.
At eight years old, Ornela Maric became a child living with a parent with a life-threatening illness. In 1980, her mom got breast cancer. The years that followed dramatically impacted Ornela's identity, and who she grew up to become. The most profound impact would be on the power of mindset, and in particular, how her mother role modeled responding to a prognosis by not accepting it as reality. . How did her mother's condition and perspective inform Ornela's formative years? Discover how she shifted from victimhood and fear ot the power of “genetic destiny” to a sense of freedom over her life. Find out what her most important source of strength was during childhood. . Bio When I was just 8, my mother was diagnosed with breast cancer and was told her life expectancy was 5 years. As my childhood abruptly became defined by the fear of losing her, and as more family members started getting all kinds of cancers over the years, I unconsciously adopted the mindset of being a victim of my genes. . I carried that mindset well into my 40s until I started learning about the impact of unprocessed emotions on the onset of health issues and on our overall health and well-being. I understood how my mother defied being identified by and through the diagnosis, and how she managed to live a good, quality life 3x longer than the prognosis she was given. I also embarked on an even deeper journey of my own healing after losing her, through which I had also become aware that growing up by her side had taught me so much more than I was initially aware of, and had planted a seed of the work I do today. . Initially trained as an engineer, in my mature years I discovered therapy work as my true labor of love. Today I have my own online practice in which I combine my analytical and problem-solving skills, with lessons learned from my late mother, and my passion for working with people on resolving their own traumas to help them develop unshakeable self-love and solid self-care practices, so they to create lives in which they are not just coping but thriving, no matter their age or circumstances. Guest Info. http://om-transformations.com/ https://instagram.com/om.transformations Julie's Info. Julie@courage-ignite.com https://www.courage-ignite.com/ https://linkedin.com/in/julie-browne-courage-ignite https://www.instagram.com/juliebrownecourageignite/ https://facebook.com/juliebrownecourageignite Podcast — Bold Becoming Book — Masters of Change—if you're not already on my mailing list, sign up here so you'll get the email when Masters of Change is available for purchase. Music — Happy African Village by John Bartmann --- Send in a voice message: https://podcasters.spotify.com/pod/show/julie-browne/message Support this podcast: https://podcasters.spotify.com/pod/show/julie-browne/support
In this episode:00:30 Early humans pushed to brink of extinctionAround 900,000 years ago the ancestors of modern humans were pushed to the brink of extinction, according to new research. Genetic studies suggest that the breeding population of our ancestors in Africa dropped to just 1,280 and didn't expand again for another 117,000 years. This population crash would likely have had an impact on human genetic diversity, and may have driven the evolution of important features of modern humans, such as brain size.Nature News: Human ancestors nearly went extinct 900,000 years ago3:49 The pollution legacy of Antarctica's research stationsPoor historical waste practices have left high levels of pollution around Antartica's research facilities. By surveying the seafloor near Australia's Casey research station, researchers have revealed high concentrations of hydrocarbons and heavy metals.This pollution is likely to be widespread, but its impact on the continent is unknown.Nature News: Antarctic research stations have polluted a pristine wilderness07:43 Melting sea-ice causes catastrophic penguin breeding failurePersistently low levels of sea-ice around Antarctica have caused emperor penguins to abandon their breeding colonies early, resulting in the death of large numbers of chicks. Although the affected populations only represent a small number of the total emperor penguins on the continent, it's unclear how they'll fare if trends in sea-ice melt continue.Science: Emperor penguins abandon breeding grounds as ice melts around them09:23 The AI trained to describe smellsResearchers have developed an artificial-intelligence that can describe how compounds smell by analysing their molecular structures. The system's description of scents are often similar to those of trained human sniffers, and may have applications in the food and perfume industries. Currently the AI works on individual molecules, and is unable to identify the smells associated with complex combinations of molecules, something humans noses do with ease.Nature: AI predicts chemicals' smells from their structuresSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.
A new editorial paper was published in Oncotarget's Volume 14 on August 30, 2023, entitled, “Subpopulations of AIB1 isoform-expressing breast cancer cells enable invasion and metastasis.” In their new editorial, researchers Amber J. Kiliti, Ghada M. Sharif, Anton Wellstein, and Anna T. Riegel from Georgetown University Medical Center discuss potential mechanisms of breast cancer invasion and metastasis. Genetic and epigenetic events drive individual tumor cells to proliferate and expand into a heterogeneous mixture of cells that evade immune surveillance, acquire the ability to invade the vasculature and spread as metastatic seeds to distant sites. Organ metastasis contributes to more than 90% of all cancer-related deaths. “The model of Darwinian evolution explains the stepwise selection of cancer cells capable of invasion and metastatic spread and an extensive body of work supports that cancer cell-autonomous features match the selected cancer cell ‘seed' with the appropriate ‘soil' of the target organ.” However, this concept was challenged in a recent paper in Cancer Research. Sharif et al. observed that a subclonal population of cells in a heterogeneous tumor can significantly alter the growth characteristics, invasiveness and metastasis of an entire tumor through cell-cell crosstalk. These functionally relevant cell subpopulations are difficult to detect through bulk analysis though their presence may influence disease outcome and efficacy of treatments. “In their paper, Sharif et al. detailed how expression of a splice isoform of the transcriptional coregulator and oncogene Amplified In Breast Cancer 1 (AIB1) in a small subpopulation of cells can lead to increased tumor growth and invasion of surrounding tissues by ductal carcinoma in situ (DCIS) cells.” DOI - https://doi.org/10.18632/oncotarget.28452 Correspondence to - Anna T. Riegel - ariege01@georgetown.edu Video short - https://www.youtube.com/watch?v=_yZnwzitBek Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28452 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, AIB1, AIB1Δ4, breast cancer, invasion, metastasis About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957
Genetic genealogy is a field that combines traditional genealogy research with modern DNA testing techniques to trace familial relationships and ancestry through genetic information. It involves analyzing an individual's DNA to uncover their genetic heritage, connect with distant relatives, and map out family trees. This approach has gained significant popularity due to advancements in DNA sequencing technology, particularly in the form of direct-to-consumer DNA testing kits.Here's how genetic genealogy works and how it's used by investigators:DNA Testing: Individuals interested in exploring their genetic heritage and family history can submit their DNA samples through services provided by companies like AncestryDNA, 23andMe, and MyHeritageDNA. These companies analyze specific segments of the submitted DNA to identify genetic markers that are common among different populations and individuals.Genetic Markers: Certain sections of the DNA, particularly those found in the Y chromosome (passed from father to son) and the mitochondrial DNA (passed from mother to all offspring), contain genetic markers that can be used to identify ancestral lineages. Autosomal DNA, which is inherited from both parents, is also examined to find matches with other individuals in the testing company's database.Matching and Comparison: Testing companies compare an individual's genetic markers with those of other users in their databases. If two individuals share a significant amount of genetic material, they are considered genetic matches. The more segments of DNA they share, the closer their relationship is likely to be.Building Family Trees: Genetic genealogy involves constructing family trees using a combination of traditional genealogical research and the information gained from DNA matches. By connecting with other users who share segments of DNA, individuals can extend their family trees and discover new branches of their lineage.Identifying Common Ancestors: As more people participate in DNA testing, the chances of finding common ancestors increase. Overlapping segments of shared DNA can help identify specific ancestors or ancestral groups that are shared among related individuals.Forensic and Investigative Applications: Genetic genealogy has also found applications in criminal investigations. Law enforcement agencies have used DNA databases to identify unknown perpetrators of crimes like murder and sexual assault. In cases where traditional investigative methods have been unsuccessful, investigators can upload DNA profiles from crime scenes to genealogy databases and identify potential relatives of the suspect based on shared genetic markers.Building Family Trees for Identification: Once potential relatives of the suspect are identified, investigators work to build family trees using genealogical records, such as birth certificates, marriage records, and obituaries. By tracing the shared ancestry of these relatives, law enforcement can narrow down the list of potential suspects to a smaller pool.Narrowing Down Suspects: Investigative genetic genealogy can help law enforcement focus on specific individuals who fit the profile of the unknown suspect based on age, location, and other relevant factors. This process has led to the successful identification and capture of suspects in several high-profile cases.With Investigators still searching for answers about the identity of the suspected murderer of Rachel Morin, will genetic genealogy technology provide the break through that leads to an arrest? Let's dive in!(commercial at 8:34)to contact me:bobbycapucci@protonmail.comsource:Forensic genealogy could solve Rachel Morin murder, but scientists face unique hurdles, experts say | Fox NewsThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5003294/advertisement
Today's listener question is one we touch on often at Consummate Athlete. Can you keep improving as you age? What is the limit of your progression and can you stop aging (the answer is no to that last one!). SHOW SPONSOR Get Your Free Bonus from AG1- drinkAG1.com/MOLLYH - to receive your bonus of a free 1-year supply of Vitamin D and 5 Free Travel Packs This episode is brought to you by 3 Month 100% Made for You Training Plans by Consummate Athlete - These popular plans are made from scratch for you to fit your goals, your schedule, your gear, and your goals. https://consummateathlete.com/training-plans/ Download or find links in your favorite Podcast App (remember to rate and review!) https://directory.libsyn.com/shows/view/id/consummateathlete Show Notes Peter Attia - Outlive (Book) Built to Move - Kelly and Juliette Starrett (book) Jonathan Beverly - Age Graded Results (podcast) Joe Friel Fast after 50 (book) Joe Friel on Consummate Athlete Podcast Menopause episodes of Consummate Athlete Stacy Sims episodes of Consummate Athlete Book ROAR - by Stacy Sims One Metric to Rule them All (Post) Links to Our Article Archive & Services: ConsummateAthlete.com SUPPORT THE SHOW WHILE YOU SHOP: https://amzn.to/3Aej4jl to shop amazon Subscribe to our Newsletter the latest podcast, articles and bike skills information each Monday Book a Call to Discuss Your Training - https://calendly.com/smartathlete Books By Molly Hurford https://amzn.to/3bOztkN Get The Consummate Athlete Book - LINK Follow The Consummate Athlete on Twitter and Instagram and Facebook Follow Molly Hurford on Twitter and on Instagram Follow Peter Glassford Follow @PeterGlassford on Instagram and Twitter Past guests Include: Stacy Sims, Stephen Seiler, Simon Marshall, Frank Overton, Dean Golich, Joe Friel, Marco Altini Katerina Nash, Geoff Kabush, Ellen Noble, Phil Gaimon, David Roche, Matt Fitzgerald, Dr. Marc Bubbs, Christopher McDougall, Rebecca Rusch, Kate Courtney, David Epstein and many more
Genetic genealogy is a field that combines traditional genealogy research with modern DNA testing techniques to trace familial relationships and ancestry through genetic information. It involves analyzing an individual's DNA to uncover their genetic heritage, connect with distant relatives, and map out family trees. This approach has gained significant popularity due to advancements in DNA sequencing technology, particularly in the form of direct-to-consumer DNA testing kits.Here's how genetic genealogy works and how it's used by investigators:DNA Testing: Individuals interested in exploring their genetic heritage and family history can submit their DNA samples through services provided by companies like AncestryDNA, 23andMe, and MyHeritageDNA. These companies analyze specific segments of the submitted DNA to identify genetic markers that are common among different populations and individuals.Genetic Markers: Certain sections of the DNA, particularly those found in the Y chromosome (passed from father to son) and the mitochondrial DNA (passed from mother to all offspring), contain genetic markers that can be used to identify ancestral lineages. Autosomal DNA, which is inherited from both parents, is also examined to find matches with other individuals in the testing company's database.Matching and Comparison: Testing companies compare an individual's genetic markers with those of other users in their databases. If two individuals share a significant amount of genetic material, they are considered genetic matches. The more segments of DNA they share, the closer their relationship is likely to be.Building Family Trees: Genetic genealogy involves constructing family trees using a combination of traditional genealogical research and the information gained from DNA matches. By connecting with other users who share segments of DNA, individuals can extend their family trees and discover new branches of their lineage.Identifying Common Ancestors: As more people participate in DNA testing, the chances of finding common ancestors increase. Overlapping segments of shared DNA can help identify specific ancestors or ancestral groups that are shared among related individuals.Forensic and Investigative Applications: Genetic genealogy has also found applications in criminal investigations. Law enforcement agencies have used DNA databases to identify unknown perpetrators of crimes like murder and sexual assault. In cases where traditional investigative methods have been unsuccessful, investigators can upload DNA profiles from crime scenes to genealogy databases and identify potential relatives of the suspect based on shared genetic markers.Building Family Trees for Identification: Once potential relatives of the suspect are identified, investigators work to build family trees using genealogical records, such as birth certificates, marriage records, and obituaries. By tracing the shared ancestry of these relatives, law enforcement can narrow down the list of potential suspects to a smaller pool.Narrowing Down Suspects: Investigative genetic genealogy can help law enforcement focus on specific individuals who fit the profile of the unknown suspect based on age, location, and other relevant factors. This process has led to the successful identification and capture of suspects in several high-profile cases.With Investigators still searching for answers about the identity of the suspected murderer of Rachel Morin, will genetic genealogy technology provide the break through that leads to an arrest? Let's dive in!(commercial at 8:34)to contact me:bobbycapucci@protonmail.comsource:Forensic genealogy could solve Rachel Morin murder, but scientists face unique hurdles, experts say | Fox NewsThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5080327/advertisement
Before we begin our program today, I want to read from a report from CNN, from 2002."The leader of a religious sect that claimed to have created the first human clone Friday called the development "just the first step" toward human immortality through cloning.Former French journalist Claude Vorilhon, who now calls himself Rael, claims to be a direct descendant of extraterrestrials who created human life on Earth through genetic engineering. A company founded by his followers announced Friday that the first human clone has been born -- a 7-pound baby girl dubbed "Eve."The announcement was met with skepticism and concern, since other cloned mammals have had serious birth defects or developed health problems later. But in an interview with CNN, Rael dismissed concerns about health problems in cloned animals, saying, "I have no doubt the child will be perfectly healthy."The Raelians eventually hope to develop adult clones into which humans could transfer their brains, Rael said."Today we present one of the most interesting interviews Rick Wiles has ever conducted. In this conversation from March 6, 2002, Rick speaks with Rael, where they discuss cloning, the origins of humanity, and visitors from space. Buckle up, here's Rick.Rick Wiles, Doc Burkhart. Airdate 9/1/23You can partner with us by visiting TruNews.com/donate, calling 1-800-576-2116, or by mail at PO Box 690069 Vero Beach, FL 32969.It's the Final Day! The day Jesus Christ bursts into our dimension of time, space, and matter. Now available in eBook and audio formats! Order Final Day from Amazon today! https://www.amazon.com/Final-Day-Characteristics-Second-Coming/dp/0578260816/Apple users, you can download the audio version on Apple Books!https://books.apple.com/us/audiobook/final-day-10-characteristics-of-the-second-coming/id1687129858Purchase the 4-part DVD set or start streaming Sacrificing Liberty today. https://www.sacrificingliberty.com/watchThe Fauci Elf is a hilarious gift guaranteed to make your friends laugh! Order yours today! https://tru.news/faucielf
Angela interviews Dr Jill Carnahan, who shares their personal journey of dealing with the impact of toxic chemicals on their health and highlights the alarming increase in the number of chemicals introduced into our environment each year, with little regulation or testing by authorities. KEY TAKEAWAYS The exposure to toxic chemicals, such as glyphosate, is a major contributor to modern illnesses, chronic conditions, autoimmunity, and cancer epidemics. The regulation and testing of chemicals in the environment, especially in the US, is inadequate, leading to the introduction of hundreds of thousands of new chemicals each year. Genetic predispositions, combined with environmental factors like chemical exposure and dietary choices, can contribute to the development of diseases such as cancer and Crohn's disease. BEST MOMENTS "This is the elephant in the room of our modern illness, our chronic conditions, our autoimmunity, our epidemics of cancer." "We're all swimming in toxic soup." "If you're not actively thinking about ways for your environment to have clean air, clean water, clean food, then you're behind the eight ball." VALUABLE RESOURCES Episode 253 - https://omny.fm/shows/high-performance-health/the-science-and-faith-of-resilience-unlocking-the Join The High Performance Health Community Take My Biohacking Quiz and Get A Free Personalised Report - www.yourtotalhealthcheck.comBecome an Insider of The Female Biohacker Collective and have Angela as Your Health Coach in Your Pocket - www.femalebiohacker.comFree Fasting Guide - www.angelafosterperformance.com/fastingPodcast Shownotes - www.angelafosterperformance.com/podcasts To take advantage of our Biostack special offer go to https://biostacklabs.com/pages/angela To express your interest in the Biosyncing program go to angelafoster.me/biosyncing ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. Angela's BioSyncing®️ Blueprint is currently closed. Click here to get on the waitlist. She is also the founder of The Female Biohacker Collective - the health coaching membership in your pocket - with monthly live masterclasses, coaching calls and biohacking toolkits. To find out more and become a member, click here. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedInThis show was brought to you by Progressive Media
Genetic genealogy is a field that combines traditional genealogy research with modern DNA testing techniques to trace familial relationships and ancestry through genetic information. It involves analyzing an individual's DNA to uncover their genetic heritage, connect with distant relatives, and map out family trees. This approach has gained significant popularity due to advancements in DNA sequencing technology, particularly in the form of direct-to-consumer DNA testing kits.Here's how genetic genealogy works and how it's used by investigators:DNA Testing: Individuals interested in exploring their genetic heritage and family history can submit their DNA samples through services provided by companies like AncestryDNA, 23andMe, and MyHeritageDNA. These companies analyze specific segments of the submitted DNA to identify genetic markers that are common among different populations and individuals.Genetic Markers: Certain sections of the DNA, particularly those found in the Y chromosome (passed from father to son) and the mitochondrial DNA (passed from mother to all offspring), contain genetic markers that can be used to identify ancestral lineages. Autosomal DNA, which is inherited from both parents, is also examined to find matches with other individuals in the testing company's database.Matching and Comparison: Testing companies compare an individual's genetic markers with those of other users in their databases. If two individuals share a significant amount of genetic material, they are considered genetic matches. The more segments of DNA they share, the closer their relationship is likely to be.Building Family Trees: Genetic genealogy involves constructing family trees using a combination of traditional genealogical research and the information gained from DNA matches. By connecting with other users who share segments of DNA, individuals can extend their family trees and discover new branches of their lineage.Identifying Common Ancestors: As more people participate in DNA testing, the chances of finding common ancestors increase. Overlapping segments of shared DNA can help identify specific ancestors or ancestral groups that are shared among related individuals.Forensic and Investigative Applications: Genetic genealogy has also found applications in criminal investigations. Law enforcement agencies have used DNA databases to identify unknown perpetrators of crimes like murder and sexual assault. In cases where traditional investigative methods have been unsuccessful, investigators can upload DNA profiles from crime scenes to genealogy databases and identify potential relatives of the suspect based on shared genetic markers.Building Family Trees for Identification: Once potential relatives of the suspect are identified, investigators work to build family trees using genealogical records, such as birth certificates, marriage records, and obituaries. By tracing the shared ancestry of these relatives, law enforcement can narrow down the list of potential suspects to a smaller pool.Narrowing Down Suspects: Investigative genetic genealogy can help law enforcement focus on specific individuals who fit the profile of the unknown suspect based on age, location, and other relevant factors. This process has led to the successful identification and capture of suspects in several high-profile cases.Bryan Kohberger was tracked down by authorities using genealogy according to sources. While the process is not even admissable in court, it is an important tool for investigators who are trying to solve complex cases.In this episode, we hear from one of the industry leaders in the field of genealogy who is discussing how the process works and what goes into an operation such as this.(commercial at 12:11)to contact me:bobbycapucci@protonmail.comsource:How Idaho cops used genetic genealogy to trace suspect Bryan Kohberger's distant relatives | Daily Mail OnlineThis show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5080327/advertisement
In this episode, we review the high-yield topic of Genetic Pearls from the Basic Science section. Follow Orthobullets on Social Media: Facebook: www.facebook.com/orthobullets Instagram: www.instagram.com/orthobulletsofficial Twitter: www.twitter.com/orthobullets LinkedIn: www.linkedin.com/company/27125689 YouTube: www.youtube.com/channel/UCMZSlD9OhkFG2t25oM14FvQ --- Send in a voice message: https://podcasters.spotify.com/pod/show/orthobullets/message
Unraveling the COMT Gene Are You a Worrier or a Warrior?
Uncover the Incredible Journey of Pradeep Sacitharan: From War Refugee to Award-Winning Scientist Welcome to an inspiring episode that delves into a story of resilience, determination, and the transformative power of mindset. Meet Our Extraordinary Guest: Pradeep SacitharanDiscover the extraordinary odyssey of Pradeep Sacitharan, once a war refugee turned teenage gangster and serial dropout, who defied the odds to emerge as an award-winning scientist at prestigious institutions like Oxford and Harvard within just 7 years. His journey doesn't stop there – Pradeep's remarkable achievements include spearheading the discovery of 4 groundbreaking medicines as a Professor and ascending to the role of Vice President at a Biotech giant with a staggering revenue of 1.6 billion USD, all before turning 30. Highlights from the EpisodeJoin us as we dive deep into Pradeep's life journey, where he challenges conventional norms, reshapes his career trajectory, and establishes an 8-figure company, all while mastering the art of overcoming challenges with the right mindset. Key Insights from Pradeep Overcoming Adversity: From Gangster to Scientific LuminaryNavigating the Unknown: A War Refugee's TaleLearning vs. Studying: Unveiling Two Vital ConceptsDefying Limits: Challenging the Boundaries of ScienceIgniting Passion: The Role of Emotional Drive in LearningTurning Point: A Near-Fatal Experience that Changed Everything Tune In to Transform Your PerspectiveEager to be inspired by Pradeep's incredible life journey? Tune in to this episode and gain insights into conquering challenges, shaping destiny, and fostering a growth-oriented mindset. Stay Connected and EngageStay informed about upcoming episodes that offer impactful stories and lessons. Don't forget to subscribe, like, and share to be part of a community that thrives on inspiration and personal growth.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Wendy Chung is a board-certified clinical and molecular geneticist with more than 25 years of experience in human genetic disease research. In this episode, Wendy delves deep into the world of genetics by first exploring the historical landscape of genetics prior to decoding the human genome, contrasting it with what we know today thanks to whole genome and exome sequencing. She provides an overview of genetic testing by differentiating between various genetic tests such as direct-to-consumer, clinical, whole genome sequencing, and more. Additionally, Wendy unravels the genetic underpinnings of conditions such as PKU, breast cancer, obesity, autism, and cardiovascular disease. Finally, Wendy goes in depth on the current state and exciting potential of gene therapy while also contemplating the economic implications and ethical nature of gene editing. We discuss: Wendy's interest in genetics and work as a physician-scientist [2:45]; The genetics of phenylketonuria (PKU), a rare inherited disorder [5:15]; The evolution of genetic research: from DNA structure to whole genome sequencing [18:30]; Insights and surprises that came out of the Human Genome Project [28:30]; Overview of various types of genetic tests: direct-to-consumer, clinical, whole genome sequencing, and more [34:00]; Whole genome sequencing [39:30]; Germline mutations and the implications for older parents [45:15]; Whole exome sequencing and the importance of read depth [50:30]; Genetic testing for breast cancer [54:00]; What information does direct-to-consumer testing provide (from companies like 23andMe and Ancestry.com)? [1:01:30]; The GUARDIAN study and newborn genetic screening [1:06:30]; Treating genetic disease with gene therapy [1:18:00]; How gene therapy works, and the tragic story of Jesse Gelsinger [1:22:00]; Use cases for gene therapy, gene addition vs. gene editing, CRISPR, and more [1:28:00]; Two distinct gene editing strategies for addressing Tay-Sachs and fragile X syndrome [1:37:00]; Exploring obesity as a polygenic disease: heritability, epigenetics, and more [1:41:15]; The genetics of autism [1:48:45]; The genetics of cardiovascular disease [2:01:45]; The financial costs and economic considerations of gene therapy [2:06:15]; The ethics of gene editing [2:12:00]; The future of clinical genetics [2:21:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
Breaking Genetic Chains: Transforming Your Health Story Hello beautiful humans, thank you for listening and supporting the Thrive Forever Fit Show. It truly means the world to me that you take time out of your precious day to listen to me ramble and rant about things I found entertaining, engaging, and meaningful. Show Sponsor: SpaStar www.spastar.net The Get Ready Wrap™ is spa-inspired and made for virtually every body. Designed with comfort and eco-elegance in mind - no velcro, snaps, or bulky material that take up too much room in your closet, laundry, or suitcase. This luxury spa wrap is perfect for spa treatments, beauty rituals, special occasions, getting ready, makeup tutorials, travel, by the pool, and the gym bag.Discount Code to Save 15% Off Your Get Ready Wrap: THRIVE15 Welcome to an eye-opening episode that explores the intricate connection between genetics, the environment, and human health. Inspired by the thought-provoking quote "genetics loads the gun, but the environment pulls the trigger," we delve into the fascinating world of epigenetics and the empowering concept that our lifestyle choices can play a significant role in overcoming genetic predispositions to diseases. Join us as we unravel the secrets of how you can take charge of your health and well-being, even in the face of challenging genetic factors. Episode Highlights: #1 Understanding the "Genetics Loads the Gun" Concept: *Exploring the role of genetics in determining disease susceptibility. *Unpacking the idea that genes are not destiny and how they only set the stage. #2 The Power of Epigenetics: *Introducing the concept of epigenetics and its impact on gene expression. *How environmental factors and lifestyle choices influence epigenetic changes. #3 Embracing a Healthy Lifestyle: *The importance of nutrition, exercise, and sleep in influencing gene expression. *How making positive lifestyle choices can counteract genetic predispositions. #4 Nurturing a Supportive Environment: *Recognizing the role of the environment in shaping health outcomes. *Strategies for creating a nurturing and health-promoting environment. #5 Mind-Body Connection: *Exploring the link between mental well-being and gene expression. *Techniques for managing stress and improving overall health. #6 Seeking Professional Guidance: *When and how to consult with healthcare professionals about genetic risks. *Understanding the importance of personalized healthcare approaches. #7 Real-Life Success Stories: *Inspiring stories of individuals who overcame genetic challenges through lifestyle changes. *How their experiences can provide hope and motivation. #8 Empowering Yourself: *Recognizing the factors within your control and those outside of it. *How embracing a proactive mindset can positively impact your health journey. As we conclude this enlightening episode, we hope you've gained a deeper understanding of the dynamic interplay between genetics, the environment, and human health. Remember, genetics may load the gun, but you have the power to influence whether it gets fired. By making conscious choices, adopting a healthy lifestyle, and creating a supportive environment, you can overcome genetic predispositions and lead a vibrant and fulfilling life. Always remember that your health is a journey, and every decision you make has the potential to shape your well-being positively. Join us next time for another inspiring episode filled with valuable insights and practical tips for personal development. Stay empowered, and remember that happiness and abundance are within your reach. Links: Thrive Forever Fit Supplements Thrive Forever Fit Coaching Program Thrive Fitness Studio FREE Facebook Group: Wellness Lab Best Selling Books: The Overweight Mind The Purpose of Pain
AP correspondent Julie Walker reports on MED Genetic Testing Babies
Welcome to Protecting Your Nest with Dr. Tony Hampton. Dr. Paul E. Marik is the co-Founder of the Frontline Covid-19 Critical Care Alliance—an alliance of doctors and medical scientists from around the world. Dr. Marik is a pioneer in medical research and is a former professor. He is the second most published critical care specialist in the world. In today's episode, we discuss his most recent publication which is an extensive review of the evidence on the use of repurposed medications for treating cancer. In this discussion, Drs. Tony and Paul talk about: (05:16) The importance of having no conflicts of interest in medical research (06:21) Why the risk of cancer is increasing in our modern world (07:48) Why cancer is NOT a genetic disease and why many tumors cannot be cured by chemo therapy (11:43) The role of the stem cell in the development of cancer (13:30) The conventional theory of cancer and why it is wrong (15:08) One of the most effective ways to kill cancer cells: starve them of glucose (21:14) How cancer cells proliferate in the body (24:44) The Metabolic versus the Genetic theory of cancer and why processed foods, sugary drinks, lack of exercise, and poor sleep are cancer promoters (27:47) A study finding that a group who took Vitamin D, Omega-3, and followed a home exercise routine reduced their risk of cancer by 60% (31:13) The value of various drugs for the treatment of cancer (34:34) The most effective interventions for fighting cancer (37:48) Why diet is SO important for avoiding cancer and why glucose is especially bad (40:51) The differences between chemo and repurposed drugs (48:29) Cancers which are curable with surgery (48:59) Concluding thoughts Thank you for listening to Protecting Your Nest. For additional resources and information, please see the links below. Links: Dr. Paul E. Marik: FLCCC Dr. Tony Hampton: Linktree Instagram Account LinkedIn Account Ritmos Negros Podcast Q Med Symposium for Metabolic Health Lectures How Waking Up Every Day at 4:30 Can Change Your Life
Last month, an article published on NBC described “[p]ractitioners of ‘race change to another,' or RCTA,” which refers to people who “purport to be able to manifest physical changes in their appearance and even their genetics to truly become a different race.” Interviewed for the article were teenagers who are enamored with Japanese and Korean cultures and who have become convinced that, by listening to subliminal messages while they sleep, they will eventually wake up with Asian characteristics, such as eyes with an epicanthic fold. Even more unbelievable than the idea that subliminal messaging can alter a person's genetics was the attempt at ethical analysis by journalist Emi Tuyetnhi Tran. According to Tran, RCTA is wrong, but not because those with the delusion entertain desires that will never become reality. Instead, RCTA is wrong because of inequality: Experts agree race is not genetic. But they contend that even though race is a cultural construct, it is impossible to change your race because of the systemic inequalities inherent to being born into a certain race. In other words, young people with this particular identity crisis should not be told what they desire is impossible due to the constraints of physical reality, but that they are violating certain social theories. What Tran fails to explain is that if race is merely a social construct as gender is now understood to be, why is appropriating a different gender identity acceptable but not a different racial identity? On what grounds should we, for example, oppose the actions of someone like Rachel Dolezal, a white woman who became leader of a local NAACP chapter? In fact, though there are physical distinctions between races, the physical differences between the sexes are far more profound. Nineteenth century ideas of divinely ordained, distinct races that ought not be “mixed” was rooted in dangerous, racist nonsense that can neither be supported biblically or biologically. The differences that are emphasized are typical generalizations more closely related to cultural differences than anything essential. However, people have tended to tie these assumptions to racial categories. The biblical account, in contrast, describes a single human race that was created by God to bear His image before the rest of His creation. The different “tongues, tribes, nations, and languages” arose when God dispersed Noah's descendants, spreading humans across the Earth to fulfill their purpose. Thus, the biblical narrative grounds and explains both the universal dignity and value that all humans possess, as well as their physical, cultural, and genetic differences. Race is too narrow a concept to explain these differences. It is best understood, as apologists Neil Shenvi and Pat Sawyer explain in their forthcoming book Critical Dilemma, as a social construct (though not all differences can be attributed to social construction). Genetic variances among people are significant enough to produce observable physical differences. For example, different races demonstrate specific predilections towards different kinds of cancer. Even if a few confused teenagers believe that epicanthic folds are only a social construct and not genetic, that doesn't change reality. What becomes obvious in Tran's article is that acknowledging these realities without violating our society's “new rules” requires quite a bit of intellectual gymnastics. For example, one article cited by Tran suggests that genetic variation among humans should be understood wholly differently than the concept of race. A Ph.D. candidate at Harvard Medical School suggests the use of “ancestry” language instead of “race” language. This quickly feels like a word game, especially when the only ones allowed to use the word “race” are those who lob accusations of racial supremacy. The more fundamental problem–the one at the root of this and every one of the many identity crises infecting our cultural moment–is that so many young people have absorbed a way of thinking about themselves and reality best identified as “expressive individualism.” For years, they've heard that the world is whatever they decide and make of it, that their bodies are plastic and do not govern who or what they are, and that what is most true about themselves and the world is how they feel on the inside. Why wouldn't they assume that one day they could wake up with the eyelids they really, really want? An overwhelming identity crisis among young people is also a clear indicator of what the Church is being called to in this time and this place. Testifying to the work of Christ in the world, which is always the calling of the Christ-follower, must include testifying to the work of Christ in creation. John 1 and Colossians 1 are clear: Christ was present and at work in the creation chapter of God's story. Proclaiming the Good News today must involve pointing to God's good design of human beings, how He created them in His image. That must include theological instruction about the human body, especially in the wake of a dramatic increase in depression and anxiety among teens and of a growing number “detransitioners” dealing with regret and facing the long-term harm of our culture's worst ideas. This Breakpoint was co-authored by Dr. Heather Peterson. For more resources to live like a Christian in this cultural moment, go to breakpoint.org.
We shall soon be seeing the implementation of biometric structures for identification and so-called pandemic control. The rollouts of biochips placed in the hand or elsewhere are already used in many countries worldwide. Spurred in part by the COVID-19 pandemic and the push for digital vaccine “passports,” a growing number of governments are considering implementing biometric digital ID programs whereby citizens will be required to obtain digital identification credentials to access public goods and services. It is becoming apparent that a global technocratic takeover is underway. How do we fight against this Antichrist system? Tonight on Ground Zero, Clyde Lewis talks about MARKED - LIFE IN THE DIGITAL GENETIC PANOPTICON. #GroundZero #ClydeLewis #VaccinePassport #DigitalID https://groundzeromedia.org/8-24-23-marked-life-in-the.../ Ground Zero with Clyde Lewis is live M-F from 7-10pm, pacific time, and streamed for free at https://groundzero.radio and talkstreamlive.com. For radio affiliates near you, go to talkmedianetwork.com. To leave a message, call our toll-free line at 866-536-7469. To listen by phone: 717-734-6922. To call the live show: 503-225-0860. For Android and iPhones, download the Paranormal Radio app. For additional show information, go to groundzeromedia.org. In order to access Ground Zero's exclusive digital library which includes webinars, archived shows/podcasts, research groups, videos, documents, and more, you need to sign up at aftermath.media. Subscriptions start at $7/month. Check out the yearly specials!
Dr. Bruce Lipton is a renowned cellular biologist and author whose groundbreaking research has revolutionized our understanding of the connection between our perception and genetics. Through his work, Dr. Lipton has challenged the conventional belief that our genes solely determine our health and destiny.His research highlights the profound impact our thoughts and perceptions have on our biology. According to Dr. Lipton, the way we perceive and interpret our circumstances directly influences the behavior of our cells and, subsequently, our overall health and well-being.Lipton's findings suggest that positive and empowering beliefs can trigger favorable genetic expressions, leading to improved immune responses, increased energy levels, and better overall health. Conversely, negative or stressful thoughts can activate genes associated with illness, creating a fertile ground for diseases to manifest.Dr. Bruce Lipton's work serves as a reminder of the incredible power we hold in shaping our own destinies. It emphasizes the importance of adopting a positive mindset and cultivating a healthy perception of life to promote a healthier, more vibrant existence. This groundbreaking understanding bridges the gap between mind and body, empowering us to take charge of our health and harness the transformative potential of our thoughts.In this interview with Bruce Lipton, you'll discover:-The Sixth Mass Extinction, and why chaos can be the best thing for humanity!...01:30-We can start building a better version of civilization...08:00-A life out of harmony activates unhealthy genes, dis-ease, cancer, etc...11:00-Make yourself the master, rather than the victim...13:30-How do we begin to shift our mindset, our thoughts, etc. and in turn our genetic disposition?...16:10-Where are you "downloading" your behavior from?...19:30-The subconscious and conscious mind cannot dominate your thoughts simultaneously...25:30-Ipads and the mainstream are awful "programmers" of our subconscious...31:20-How we choose our perception of our circumstances affects our happiness and wellness...34:40-The two minds we all possess...42:00-Yes, YOU have taken the "Red Pill" a la The Matrix...46:00-Bruce gives a ringing endorsement of our beloved host, Jennifer...52:00-And much more...Resources mentioned:Bruce's websiteBruce's Community for Conscious EvolutionThe Biology of Belief by Dr. Bruce LiptonAbout the guest:Instagram Bruce's YouTubeBruce H. Lipton, Ph.D. is an internationally recognized authority in bridging science and spirit and a leading voice in new biology. A cell biologist by training, he taught at the University of Wisconsin's School of Medicine, and later performed pioneering studies at Stanford University. Author of The Biology of Belief, he has been a guest speaker on hundreds of TV and radio shows, as well as keynote presenter for national and international conferences. OM HealsQuantum physics reveals that we are 99.9999% energy and only .00001% physical matter. When we flow, move, and balance blocked energies we hold, then our mind, body and soul return to its natural state of well being.We are committed to matching you with the best possible energy meta-cine practitioners to support your wellness...
Curious about your genetic ancestry? Ready to unearth secrets about your family's past that are hidden within your DNA? Join us as we embark on a journey of discovery with Diahan Southard, creator of Your DNA Guide, who unravels the intricacies of DNA testing and genetic ancestry. Diane guides us through this enigmatic world, shedding light on the distinctions between culture, ethnicity, and heritage, and their impact on interpreting DNA test results. She introduces the concept of reference populations, highlighting its pivotal role and potential limitations in categorizing individuals to a specific location.The adventure continues as we dive deeper into the specifics of DNA ethnicity results and haplogroups. Diahan demystifies why DNA test results can vary between companies and evolve over time. She elaborates on the critical aspects of reference populations, algorithms, and statistics, and why a larger dataset can produce more accurate results. Our conversation emphasizes the importance of participating in research to improve the accuracy of results for your community, heightening the excitement of this genealogical exploration.As we round off our captivating discussion, we unveil the astonishing power of DNA testing in revealing unexpected family connections. Hear about individuals who unraveled surprising links to historical figures and places, emphasizing the significance of understanding the culture, ethnicity, and heritage of both sides of a family. Diahan offers practical tips for interpreting DNA test results, making this episode a treasure trove of knowledge for anyone intrigued by their family history or eager to learn more about the world of DNA testing. Tune in and let us embark on this journey together.Be sure to use the Coupon Code ITALIANROOTS.Farmers and Nobles traces the research path of blogger and podcast host Bob Sorrentino. Bob began researching his family roots in 2008 beginning with his great-grandfather's calling card brought from Italy by his paternal grandmother Maria Luigia Piromallo. https://www.italiangenealogy.blog/farmers-and-nobles/Your DNA Guide You don't have to learn everything about genetic genealogy before asking and answering DNA questionsDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showPurchase my book "Farmers and Nobles" here or at Amazon.
Genetic genealogy is back in the news after a motion to compel in the Idaho Murder trial. We talk about the problems with that motion and why it should fail.
This week's guest epitomises why I LOVE doing this podcast so much and, for all its downsides, embrace the potential for connection that social media allows us in this day and age. We actually met THROUGH the yayborhood after this guest became our number one purchaser of quote of the day Flip Books and the support has been unwavering ever since… I don't know how we actually got onto his incredible work, but it somehow emerged that Simon Morriss went from being an architect to becoming the CEO of an incredible biotech company and when I found out about his amazing work identifying diseases through a very simple, noninvasive saliva-based test, called geneType, I just HAD to share it with you all. After becoming friends over the interwebs for years we finally sat down and chatted about the incredibly work that he is doing. I hope you love it! The GRAZIA ARTICLE Find out more about GENETIC TECHNOLOGIES + Announcements on Insta at @spoonful_of_sarah + Join our Facebook community here + Subscribe to not miss out on the next instalment of YAY!
Have you ever found yourself stuck on a weight loss plateau, or found yourself stuck at a certain weight, despite your best efforts? Well, you're not alone! In this episode, we explore the factors that can cause weight loss plateaus and offer valuable insights on how to overcome them. Whether you have experienced a plateau or are simply curious about the science behind weight loss, this episode is packed with information that will empower you on your journey to a healthier and more fulfilling life. For women over 40, weight loss resistance can be even more challenging due to various cellular factors. But don't lose hope! I'm discussing strategies and processes that can help you break through those stubborn plateaus and achieve the results you desire. Remember, you have the power to take control of your health and well-being! I also explore the concept of refeeding and the benefits of incorporating restorative activities like yoga, stretching, and Pilates into your fitness regimen. Sometimes, we need to break free from restrictive eating and intense exercise routines to help our bodies understand that we're no longer in a starvation state. Find out how these practices can support your weight loss journey and promote overall well-being. Moreover, discover how sleep deprivation can affect your body's metabolism and learn simple steps to improve your sleep routine. As always, I strive to make complex science accessible and applicable to daily life, so you can expect a blend of expertise, relatability, and a dash of sass. Together, we will navigate the challenges that come with this second season of life - menopause - and tap into our deepest desires. Key Takeaways: [00:02:16] Weight loss resistance vs yo-yo ability. [00:04:07] My weight loss journey. [00:06:59] Weight gain and frustration. [00:10:34] Genetic changes and weight loss. [00:13:49] Starvation and pre-diabetes. [00:19:05] Starvation response and hormones. [00:22:27] Insulin resistance and metabolism. [00:25:07] Fuel partitioning in biology. [00:28:05] Glucose conversion and fat storage. [00:31:09] Doubling down on exercise. [00:34:02] Weight loss resistance and plateaus. [00:38:52] Fix weight loss resistance with proper methods. Memorable Quotes "The first thing you have to understand is that the body is designed to conserve our bodies, particularly female bodies, because nature cares about our capacity to be able to reproduce and procreate." – Betty Murray "The take-home message is we have to protect our sleep. We have to get sleep. We have to get quality sleep. We have to make sure that we protect it and that we're getting enough. And that means seven to eight hours. I know you may be able to operate on five or six, but that doesn't mean you're getting adequate sleep." – Betty Murray Website Living Well Dallas Hormone Reset Betty Murray Socials Facebook Instagram
Dementia and Alzheimer's disease are debilitating conditions that affect millions of people worldwide. The loss of memory and cognitive function can be devastating, not only for the individuals themselves but also for their loved ones. However, there is hope for reversing dementia. In this episode, I had the privilege of interviewing the incredible Dr. Heather Sandison. She is a Naturopathic Doctor who has dedicated her career to supporting those suffering with dementia, and let me tell you, the insights she shared are mind-blowing! Here are some key takeaways that I believe will have a profound impact on your life: Prioritize Your Brain Health: Dr. Heather emphasizes the importance of investing in ourselves and recognizing our own worth. Remember, you are absolutely deserving of a healthy and thriving brain! Find Your Balance: We all know that stress can take a toll on our memory and cognitive abilities. Dr. Heather highlights the significance of maintaining a balance between engagement and overwhelm. Take Action: The most crucial step is to take action! Dr. Heather encourages us to identify our one next right step towards improving our brain health. It could be as simple as adding a new habit to our daily routine or committing to a healthier diet. Remember, every small step counts, and together, they lead to remarkable transformations! I cannot stress enough how valuable this episode is, and I highly recommend giving it a listen. Dr. Heather is a true inspiration, and her expertise will leave you feeling empowered and hopeful. Key Takeaways: [00:01:15] Alzheimer's and dementia struggle. [00:05:14] Improving cognitive function in Alzheimer's. [00:08:30] Immersive experience for dementia. [00:12:38] Medications vs. natural approaches. [00:15:48] Dual task exercises. [00:19:22] Using oxygen to optimize exercise. [00:21:44] Chronic diseases and imbalance. [00:26:30] Glucotoxicity and Alzheimer's disease. [00:29:00] Oral estrogen and inflammation. [00:34:26] Genetic risk of Alzheimer's. [00:36:25] Positive attitude and longevity. [00:40:14] Red light therapy benefits. [00:44:00] Brain health improvement strategies. Where To Find Our Guest Website: https://www.drheathersandison.com/ Solcere Health Clinic: https://www.solcere.com/ Marama Experience: https://www.maramaexperience.com/ Reverse Alzheimer's Summit: https://summits.drtalks.com/reverse-alzheimers-summit/?uid=305&oid=42&ref=2309 Memorable Quotes "I wish more than anything every day. I wish there was a pill or an IV that I could give my patients to just stop the suffering. But we don't have that yet. But what we do have are these other really exciting things that we can do where the side effects are just better health and more graceful aging generally." [00:12:29] – Dr. Heather Sandison "My life's work is to change the narrative around Alzheimer's. There is hope. There's lots we can do. And the sooner we get started, the sooner we get these foundations in place, the sooner we get the toxins out and the nutrients balanced, the better our outcomes.” [00:42:51] – Dr. Heather Sandison RESOURCES MENTIONED: Mighty Maca Plus To learn more about me, and to stay connected, visit the links below: Website: The Girlfriend Doctor Instagram: The Girlfriend Doctor
Matt Spangler, Beef Genetics Specialist at the University of Nebraska, gives the nitty gritty on genetic defects; what they are and how seedstock producers should approach them. Sponsored by: Schroeder's Black Hereford schroedersblackherefords.com Triple T Farm tripletblackcattle.com Walters Cattle Farms 270-832-1180 Learn more about your ad choices. Visit megaphone.fm/adchoices
Timestamps: 01:40 Glycine and Methionine for Longevity 10:45 Risks of High Homocysteine 15:10 Why You Need Glycine 19:45 How Bad Is High Homocysteine 22:45 Optimal Protein Ratios 26:35 How Much Glycine to Take 31:57 Can Taurine Extend Lifespan 38:15 Finding Your Genetic Bottlenecks 44:08 Power of Genetics 45:26 Is MTHFR Important 55:18 How to Find Your Genetic Bottlenecks 01:00:15 Whole Genome Sequencing 01:06:35 How Important Are Your Bottlenecks 01:09:11 How to Get Your Whle Genome Sequenced 01:11:40 What to Focus on For Longevity Chris Masterjohn YouTube channel: https://www.youtube.com/@chrismasterjohn Use code SIIM https://donotage.org/ref/Siim%20Land/ to get an extra 10% discount
Thomas Seyfried is a prominent scientist and researcher in the field of cancer biology and metabolic therapies. He argues that cancer is not genetic and that, in fact, it is metabolic. Which means that chemotherapy is not necessary and that a ketogenic is effective. Full description Become a member for bonus content Subscribe to my War Report
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