Podcasts about Genetic

In Part 2 of this special two-part series on genetic lipid disorders, Susan Robbins welcomes back renowned lipidologist Dr. Tom Dayspring for an eye-opening discussion on Lipoprotein(a), often written as Lp(a), one of the most common yet overlooked genetic cardiovascular risk factors in the world. While many people focus on standard cholesterol numbers, Dr. Dayspring explains why Lp(a) deserves far more attention and why major cardiovascular organizations now recommend that every person be tested at least once in their lifetime.Together, Susan and Dr. Dayspring break down the science behind Lp(a), how it differs from traditional cholesterol markers, and why elevated levels can significantly increase the risk of atherosclerosis, stroke, and aortic valve disease. They discuss the role genetics play in determining Lp(a) levels, why lifestyle changes remain important even when they do not directly lower Lp(a), and how advanced testing can provide a more complete picture of cardiovascular risk.This conversation also tackles common misconceptions surrounding cholesterol, statins, and influencer-driven health advice. Dr. Dayspring shares practical guidance on what to do if you discover you have elevated Lp(a), how to advocate for yourself within the healthcare system, and why understanding your unique biology is essential for protecting long-term health.In this episode:What Lipoprotein(a) or Lp(a) is and why it mattersWhy Lp(a) is one of the most common genetic lipid disorders worldwideThe connection between elevated Lp(a), heart disease, stroke, and aortic valve diseaseWhy every person should consider being tested for Lp(a) at least onceHow genetics determine Lp(a) levels throughout lifeThe difference between Lp(a), LDL cholesterol, and ApoBWhy standard cholesterol testing may miss important cardiovascular risk factorsThe role of oxidized phospholipids in cardiovascular diseaseIf you've ever been told your cholesterol is "normal" but still have a family history of heart disease, stroke, or unexplained cardiovascular events, this episode offers critical information that could help you ask better questions, pursue the right testing, and become a stronger advocate for your own health.Learn more about Dr. Tom Dayspring on the website shownotes!https://healthyawakening.co/2026/06/15/episode128/RESOURCES:Connect with Dr. Tom DayspringX: https://x.com/drlipidhttps://familyheart.org/https://healthyawakening.co/2026/06/15/episode128/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Before you start trying to conceive, there's one step most people never think about, but it can completely change how you plan for a healthy pregnancy. Genetic carrier screening isn't just for people with a known family history. In fact, most carriers are completely healthy and have no idea they carry a genetic condition. So the question becomes: what don't you know and how could that information shape your choices? In today's episode, I interview genetic counselor Janet Rosenfield, who brings over 40 years of clinical and teaching experience, and Orren Alperstein, founder of Canavan Foundation, whose personal connection to this work adds a powerful, human perspective. Together, we break down what carrier screening actually is, why timing matters, and how this information can shape your fertility journey.  From real patient stories to the future of genetic testing, this conversation is all about making informed, values-based decisions as you plan to grow your family. If you're LOVING this podcast, please follow and leave a rating and review below. PLUS FOLLOW MY INSTAGRAM PAGE HERE FOR BITE SIZED TTC TIPS! For full show notes and related links: https://www.naturallynora.ca/blog/194 Need Nora's Support To Get Pregnant? Apply for Private Fertility Coaching with Nora here Click here for a collection of Nora's best self paced programs to get & stay pregnant Grab Your FREE Resources: Just starting your TTC journey? Download my Eat To Get Pregnant Guide  Having trouble getting and staying pregnant? Download my Top 3 Things To Do When You're Not Getting Pregnant Wondering what supplements to take to help you conceive? Download my Fertility Foundations Supplement Guide Please Note: The contents of this podcast are for educational and informational purposes only. The information is not to be interpreted as, or mistaken for, clinical advice. Please consult a medical professional or healthcare provider for medical advice, diagnoses, or treatment.

La dernière fois que je me suis fait une bonne bouffe, une question a popé dans ma tête : les aliments, ils viennent d'où ? D'où arrivent les tomates, patates, échalotes, haricots, prunes et pêches qu'on mange, est-ce que tout ça poussait miraculeusement en Europe dès la Préhistoire ? Eh bien sans surprise, c'est non ! En fait, beaucoup de fruits et de légumes ont leur propre histoire et leur propre géographie ! Alors on se lance au cœur de la marmite pour enquêter sur leurs origines, toutes passionnantes !Bonne écoute !

On Another Midnight With Lionel, This Episode Talks About the Increased Digital Access Provides a Broader Perspective That Proves Many Preconceived Biases About Talent to Be Entirely False. Genetic and the Technological Frontiers of Athletic Excellence. And Much More!!! Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode of RBC Pathfinders in Biopharma explores how next-generation retinal gene therapies could transform treatment for patients with wet AMD and diabetic macular edema. CCBO of 4D Molecular Therapeutics, Chris Simms, discusses the promise of reducing the burden of frequent injections through long-lasting therapies designed to preserve vision for years. The conversation also examines the firm's commercial opportunity, global roll-out ambitions, and why sustained retinal care could reshape the future of retina.

According to Dr. Sam Shay, functional genetics isn't genealogy or disease-gene testing. It's what Shay calls "terrain" genetics — identifying the upstream drivers of disease before they cascade into diagnosable conditions. As Shay shared, "Genetics testing is the cheapest, most high-value test anyone can do because done once, you have the results for life." Understanding Your Genetic Terrain Shay's work and research has identified seven major drivers of disease. These include inflammation, free radical scavenging, and liver detoxification as the highest priorities. In essence, the way people can win at genetics is to prioritize the drivers, prioritize the genes within the drivers, then prioritize the lifestyle recommendations.  Eating For Your Unique Blueprint A key discovery: the Amy1 gene (and how much of it) determines how well you break down carbs. This specific genetic marker reveals whether you should follow a keto, paleo, or high-carb diet.  For example, individuals with less of the Amy1 gene may thrive on low-carb protocols to maintain energy. Those with higher amounts may actually require higher carb intake to avoid health crashes A complete dietary genetic picture also covers: caffeine metabolism, histamine intolerance, gluten/lactose sensitivity, and sugar-craving variants Training Based On Fiber Type How should you exercise for the best results? Exercise recommendations should be designed to your genetic fiber type and recovery needs. Some people are naturally suited for power and fast-twitch movements, while others excel at endurance.  Genetic markers can also reveal your collagen strength and inflammatory response to physical stress. Ignoring these markers can lead to chronic disease or injury despite regular exercise. Functional Testing and Barbed Wire Functional labs provide a snapshot of your current health to complement your genetic structure. A concept called metabolic barbed wire can block your progress even if you follow genetic advice.  This occurs when issues like gut infections or toxins prevent your body from functioning optimally. Clearing these obstacles allows you to return to your ideal genetic terrain. In this podcast, you will discover: The difference between functional genetics and standard disease-gene testing. Why inflammation and free radical scavenging are the top priorities for health. How your Amy1 gene determines your ideal carbohydrate intake. The role of fiber type and collagen genes in preventing exercise injuries. Why vitamin D receptors matter more than your actual blood levels. The concept of metabolic barbed wire and how it blocks health progress. Which functional labs provide the most actionable insights for your body. EPISODE RESOURCES: YouTube Instagram Facebook  

How should we approach intervention thresholds, repair strategies, and lifelong surveillance in patients with genetic aortopathies? Prof. Sherene Shalhub (Oregon Health & Science University) and Prof. Rana Afifi (McGovern Medical School at UTHealth Houston) discuss the practical challenges, controversies, and unanswered questions that shape decision-making in the management of these complex patients.Shownotes: Lian T, Pai CW, Woznicki E, et al. Nonsyndromic familial type B aortic dissection exhibits distinct clinical profiles and operative outcomes. J Vasc Surg. 2026. doi:10.1016/j.jvs.2026.04.022.MacCarrick G, Afifi RO, Allen R, et al. Loeys-Dietz Syndrome: 2026 updated care management primer. Genet Med. 2026. doi:10.1016/j.gim.2026.102577.Lian T, Bhandari A, Shalhub S. What Every Vascular Surgeon Should Know About Vascular Ehlers-Danlos Syndrome. Ann Vasc Surg. 2026. doi:10.1016/j.avsg.2026.03.032.Calderon-Martinez E, Velasco WV, Guo D, et al. Differences in Arterial Events in Vascular Ehlers-Danlos, Loeys-Dietz, and Marfan Syndrome. J Am Coll Cardiol. 2025;85:2355-2367. doi:10.1016/j.jacc.2025.04.023.Shalhub S. The aortic and arterial vulnerability spectrum: A conceptual biological framework for risk stratification and precision surgical decision-making in aortopathy and arteriopathy. J Vasc Surg. 2025;82:722-739.e4. doi:10.1016/j.jvs.2025.04.028.Dittman JM, Prakash SK, Gupta PC, et al. Practice Patterns and Barriers to Vascular Genetic Testing Among Vascular Surgeons. Ann Vasc Surg. 2024;105:140-149. doi:10.1016/j.avsg.2024.01.032.Shalhub S, Byers PH. Endovascular repair of a common iliac artery aneurysm with an iliac branch device in a patient with vascular Ehlers-Danlos syndrome due to a null COL3A1 variant. J Vasc Surg Cases Innov Tech. 2023;9:101192. doi:10.1016/j.jvscit.2023.101192.Dittman JM, Saldana-Ruiz N, Newhall K, et al. Open repair of abdominal aortic aneurysms in patients with vascular Ehlers-Danlos syndrome. J Vasc Surg Cases Innov Tech. 2023;9:101194. doi:10.1016/j.jvscit.2023.101194.Shalhub S, Nkansah R, El-Ghazali A, et al. Splenic artery pathology presentation, operative interventions, and outcomes in 88 patients with vascular Ehlers-Danlos syndrome. J Vasc Surg. 2023;78:394-404. doi:10.1016/j.jvs.2023.04.007.Regalado ES, Morris SA, Braverman AC, et al. Comparative Risks of Initial Aortic Events Associated With Genetic Thoracic Aortic Disease. J Am Coll Cardiol. 2022;80:857-869. doi:10.1016/j.jacc.2022.05.054.

Madison is a mom of two living children who has also experienced three pregnancy losses along her journey to grow her family.In this episode, Madison shares how a genetic diagnosis led her to face difficult decisions about future pregnancies, her experience navigating fertility treatment, and the heartbreak of additional losses along the way. She also opens up about the importance of trusting your instincts when something doesn't feel right and the challenges of advocating for yourself during uncertain medical situations.In this conversation, we discuss:• Miscarriage, chemical pregnancy, and pregnancy loss• A genetic diagnosis and family-building decisions• IVF and fertility treatment• Self-advocacy in healthcare• Trusting your intuition• Finding hope after lossMadison's story is a powerful reminder that even in the midst of uncertainty, grief, and unanswered questions, hope can still be found.

Send Vanessa a Text MessageA special listener discount is available for Mara Labs products featured in this episode: Explore Mara Labs (Code is VANESSA)If you enjoy the podcast and want to support Vanessa's work, you can do so here: Buy Me a Coffee – Intentionally WellIn this episode, I'm joined by David Roberts, founder of Mara Labs, for a conversation exploring cellular health, modern environmental stressors, and the body's natural resilience systems.David's journey into this space began after his late wife Mara's cancer diagnosis, which led him to deeply explore plant-based compounds and how they interact with cellular protection and repair mechanisms. That path eventually led to the development of BrocElite, a stabilized sulforaphane supplement designed to support detoxification pathways, mitochondrial function, and overall cellular resilience.We discuss topics including sulforaphane, oxidative stress, detoxification and autophagy pathways, metabolic health and GLP-1 signaling, genetic variability such as MTHFR and COMT, and how modern environmental exposures like microplastics may be impacting overall health.This is a wide-ranging conversation aimed at helping make complex biology more understandable and grounded in real-life application.Key Topics Covered: Sulforaphane and cellular defense systems  Detoxification pathways and autophagy  Mitochondrial health and oxidative stress  Modern environmental exposures (including microplastics)  Metabolic health and GLP-1 signaling  Genetic variability (MTHFR / COMT) and sensitivity  Why some people feel more reactive in today's environment Sulforaphane and pet health BrocElite and Mara Labs story Connect with David:Mara Labs on InstagramExplore Mara LabsConnect with Vanessa and the podcast: IWP Website: Intentionally Well PodcastIWP Recommended ProductsPodcast on InstagramVanessa on InstagramPodcast on YouTubeVanessa on TikTokVanessa on XEmail: intentionallywellpodcast@gmail.comSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

BUFFALO, NY — June 10, 2026 — A new #research paper was #published in Volume 18 of Aging on May 18, 2026, titled “Transcriptional programs diverge in aging mouse and human skeletal muscle.” The study was led by co-first authors Charles D. Hwang and Siti Rahmayanti and corresponding author Indranil Sinha from Brigham and Women's Hospital, Harvard University. Aging is widely associated with the gradual loss of muscle mass, strength, and physical function. Much of what scientists know about these changes comes from studies in laboratory mice, which are frequently used to investigate the biological mechanisms of aging and to identify potential therapeutic targets. However, an important question remains: how closely do aging-related changes in mouse muscle reflect what actually occurs in humans? To address this question, researchers performed a detailed comparison of gene expression patterns in skeletal muscle from young and old mice and humans. The team analyzed RNA sequencing data from mouse gastrocnemius muscle and compared it with transcriptomic data from healthy young and older adults obtained through the National Institute on Aging's GESTALT study. The results revealed substantial differences between the two species. Despite both mice and humans experiencing age-related muscle decline, fewer than 5% of significantly altered biological pathways were shared between them. Many of the genetic programs that changed with aging in mice showed little resemblance to those observed in human skeletal muscle. Full press release - https://aging-us.net/2026/06/10/aging-muscle-follows-different-genetic-programs-in-mice-and-humans/ DOI - https://doi.org/10.18632/aging.206382 Corresponding author - Indranil Sinha - isinha@bwh.harvard.edu Abstract video - https://www.youtube.com/watch?v=CYKh4X1w8H0 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206382 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - hypoxia, angiogenesis, aging, skeletal muscle, regeneration To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Aaron Brown is a quantitative analyst, risk manager, and author of the new book Wrong Number: How to Extract Truth from a Blizzard of Quantitative Disinformation. https://amzn.to/4frmg3n He's also about to debate gun control at the Soho Forum in August — and his preparation for that debate is a pretty good preview of what's in the book. Topics include: why out of 28,000 gun control studies, the RAND Corporation found only 20 that weren't statistically crippled; the smoking analogy and what it tells us about legislation that runs ahead of evidence; why gun laws burden legitimate owners and not criminals; why we have a crime problem, not a gun problem; The Lancet paper that claimed US aid saved 92 million lives; how to spot three red flags that tell you a statistic is BS; and Wonder Bread's motto "Helps build strong bodies 12 ways" — which nobody ever actually wrote down. Get the book → Wrong Number: How to Extract Truth from a Blizzard of Quantitative Disinformation https://amzn.to/4frmg3n TIMESTAMPS: 0:00 — Intro — Aaron Brown and Wrong Number 0:34 — The Soho Forum gun control debate — and who he's up against 3:45 — The proposition: abolish all restrictions on adult firearm ownership 4:48 — Lou on navigating gun laws across state lines (NJ → PA → NY) 7:25 — The wide cultural divide: Scranton airport vs. any other airport with guns 9:04 — RAND Corporation: of 28,000 gun control studies, only 20 weren't crippled by errors 10:04 — The smoking analogy — legislation running ahead of the evidence 12:15 — Gun control laws only burden legitimate owners — not criminals 12:43 — The Glock switch ban and the AR-15 — targeting the popular, not the dangerous 15:18 — "Trump is a fascist" — and you want him to take the guns? 15:42 — Stop calling it a gun problem. It's a crime problem. 17:47 — We can identify the 1% of kids likely to commit 20–30% of violent crime 19:31 — Genetic markers for violence — and why that's controversial 20:48 — The Nordic prison model — does it work, and could it work here? 22:09 — Immigration data: why lumping everyone together gets you bad answers 25:20 — Lou's joke about open borders (for immigrants like his dad, not his cousins) 25:39 — Aaron's Jewish smuggler ancestors — blocked from junk dealing by licensing laws 27:04 — Did US aid really save 92 million lives? The Lancet paper that can't add up 29:13 — They saved 114% of the people — including 46M in China, which gets no aid 31:22 — Most published research findings are false — and we've known since 2005 32:42 — DOGE cuts and the "millions are dead" narrative 36:15 — Three red flags that tell you a statistic is BS 39:18 — Wonder Bread's "12 ways" — nobody ever wrote them down 40:18 — Outro — Wrong Number and the Soho Forum debate Watch full episodes on YouTube → https://www.youtube.com/watch?v=J4Vb53s4I0A&list=PLb5trMQQvT077-L1roE0iZyAgT4dD4EtJ Listen on Apple Podcasts → https://podcasts.apple.com/us/podcast/the-lou-perez-podcast/id1535032081 Listen on Spotify → https://open.spotify.com/show/2KAtC7eFS3NHWMZp2UgMVU  Lou's book — That Joke Isn't Funny Anymore: https://amzn.to/3VhFa1r  TheLouPerez.com |  info@thelouperez.com  Newsletter: https://substack.com/@louperez #Statistics #Misinformation #GunControl #USAID #AaronBrown #WrongNumber #SohoForum #LouPerezPodcast #LionsOfLiberty #DataLiteracy Learn more about your ad choices. Visit megaphone.fm/adchoices

JOIN HAMPTON:These episodes often come directly out of conversations happening inside Hampton, a private community for founders and CEOs with $3M+ in revenue or $10M+ exits. Members range from $5M net worth to billions. They wrestle with these same questions off the record. Apply at http://joinhampton.com/mw.HOW FOUNDERS ARE BUILDING WEALTH:How much do founders actually make, spend, invest, work, and keep in net worth? Hampton surveyed founders directly and put the answers into one report. Download it for free here: https://joinhampton.com/mw-wrEPISODE DETAILS:Most founders spend years learning how to make money. Almost none of them prepare for what their brain does once they have it.Henrik Cronqvist is a behavioral finance professor who trained under Nobel laureate Richard Thaler and has spent 25 years studying exactly that. His research has been cited over 7,000 times. He has studied 38,000 people to answer one uncomfortable question: how much of the way you save, spend, and invest is actually hardwired into your DNA?The answer will change how you think about every financial decision you make after an exit.This episode covers the science behind why the traits that made you a great founder may work against you as an investor, what actually happens in your brain the day the wire hits, and the one thing Henrik says every founder should do before making a single investment.TIMESTAMPS:00:00 — The traits that made you a great founder will make you a bad investor 01:45 — What is behavioral finance and why should founders care 04:35 — How Henrik got into this research (the Stockholm subway story) 06:39 — The 38,000 twin study: how much of your money behavior is genetic 10:56 — The first thing to do when the wire hits your account 12:49 — Loss aversion, performance chasing, and home bias explained 20:35 — Your personal mortgage predicts how you'll run your company's finances 30:08 — Why your brokerage app is designed to work against you 37:07 — Why founders feel depressed after selling (the science behind post-exit emotions) 47:14 — "I think I'm the exception" — and what the data actually says about that

For the Make a Wish Foundation – tune in to hear a sweet child's unique and meaningful request when granted anything she could ever want. -------- Thank you for listening! Your support of Joni and Friends helps make this show possible.     Joni and Friends envisions a world where every person with a disability finds hope, dignity, and their place in the body of Christ. Become part of the global movement today at www.joniandfriends.org   Find more encouragement on Instagram, TikTok, Facebook, and YouTube.

Aaron Brown is a quantitative analyst, risk manager, and author of the new book Wrong Number: How to Extract Truth from a Blizzard of Quantitative Disinformation. https://amzn.to/4frmg3n He's also about to debate gun control at the Soho Forum in August — and his preparation for that debate is a pretty good preview of what's in the book. Topics include: why out of 28,000 gun control studies, the RAND Corporation found only 20 that weren't statistically crippled; the smoking analogy and what it tells us about legislation that runs ahead of evidence; why gun laws burden legitimate owners and not criminals; why we have a crime problem, not a gun problem; The Lancet paper that claimed US aid saved 92 million lives; how to spot three red flags that tell you a statistic is BS; and Wonder Bread's motto "Helps build strong bodies 12 ways" — which nobody ever actually wrote down. Get the book → Wrong Number: How to Extract Truth from a Blizzard of Quantitative Disinformation https://amzn.to/4frmg3n TIMESTAMPS: 0:00 — Intro — Aaron Brown and Wrong Number 0:34 — The Soho Forum gun control debate — and who he's up against 3:45 — The proposition: abolish all restrictions on adult firearm ownership 4:48 — Lou on navigating gun laws across state lines (NJ → PA → NY) 7:25 — The wide cultural divide: Scranton airport vs. any other airport with guns 9:04 — RAND Corporation: of 28,000 gun control studies, only 20 weren't crippled by errors 10:04 — The smoking analogy — legislation running ahead of the evidence 12:15 — Gun control laws only burden legitimate owners — not criminals 12:43 — The Glock switch ban and the AR-15 — targeting the popular, not the dangerous 15:18 — "Trump is a fascist" — and you want him to take the guns? 15:42 — Stop calling it a gun problem. It's a crime problem. 17:47 — We can identify the 1% of kids likely to commit 20–30% of violent crime 19:31 — Genetic markers for violence — and why that's controversial 20:48 — The Nordic prison model — does it work, and could it work here? 22:09 — Immigration data: why lumping everyone together gets you bad answers 25:20 — Lou's joke about open borders (for immigrants like his dad, not his cousins) 25:39 — Aaron's Jewish smuggler ancestors — blocked from junk dealing by licensing laws 27:04 — Did US aid really save 92 million lives? The Lancet paper that can't add up 29:13 — They saved 114% of the people — including 46M in China, which gets no aid 31:22 — Most published research findings are false — and we've known since 2005 32:42 — DOGE cuts and the "millions are dead" narrative 36:15 — Three red flags that tell you a statistic is BS 39:18 — Wonder Bread's "12 ways" — nobody ever wrote them down 40:18 — Outro — Wrong Number and the Soho Forum debate Watch full episodes on YouTube → https://www.youtube.com/watch?v=J4Vb53s4I0A&list=PLb5trMQQvT077-L1roE0iZyAgT4dD4EtJ Listen on Apple Podcasts → https://podcasts.apple.com/us/podcast/the-lou-perez-podcast/id1535032081 Listen on Spotify → https://open.spotify.com/show/2KAtC7eFS3NHWMZp2UgMVU  Lou's book — That Joke Isn't Funny Anymore: https://amzn.to/3VhFa1r  TheLouPerez.com |  info@thelouperez.com  Newsletter: https://substack.com/@louperez #Statistics #Misinformation #GunControl #USAID #AaronBrown #WrongNumber #SohoForum #LouPerezPodcast #LionsOfLiberty #DataLiteracy Learn more about your ad choices. Visit megaphone.fm/adchoices

Jeff Dudan's free digital copy of his book What if the way you've been thinking about aging, fitness, testosterone, supplements, and even going public with your company is completely wrong? In this episode, Jeff Dudan sits down with Anthony Geisler - founder of Sequel Brands and the visionary behind Club Pilates and the Exponential Fitness empire - to unpack the truth about longevity, boutique fitness franchising, and what it really takes to build a business that outlasts adversity. Anthony shares his personal biohacking protocol, why he naturally maintains testosterone levels of 800-900 at age 50 without TRT, the real reason he holds multiple gym memberships, and how Gary Brekka's longevity science is reshaping what's possible for human lifespan. They also go deep on what going public actually feels like - including the day it became illegal to operate gyms in the United States while the company was mid-IPO - and why Anthony believes the private market gives founders something public markets never can: the ability to be masters of their own destiny. Plus, the inspiring story of a Pilates instructor with three failing studios on the verge of closing who is now on track for a $200-300 million exit. Topics covered: • Genetic methylation testing and biomarker blood panels • Natural testosterone optimization without TRT or peptides • Why muscle mass is a longevity metric, not an aesthetic one • Sauna data: 50% reduction in all-cause mortality • Red light therapy, Body20 EMS, and the Sequel Brands ecosystem • Club Pilates, Exponential Fitness, and taking a company public during COVID • The Russell 2000 and the hidden costs of public market valuations • Building franchisee loyalty and supporting humans through adversity • The shift in alcohol culture and the rise of clean eating • Gary Brekka's circadian rhythm protocols and biological age reversal  Guest: ANTHONY GEISLER  Guest YouTube: https://www.youtube.com/@Anthony.Geisler/featured  Guest Business YouTube: Guest Website: https://sequelbrands.com/  Guest Socials: https://www.linkedin.com/company/sequel-brands/    #Longevity #Biohacking #FranchiseBusiness #AnthonyGeisler #SequelBrands #ClubPilates #GaryBrekka #MensHealth #Testosterone #BoutiqueF fitness Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, Peter Penzes, PhD, director of the Center for Autism and Neurodevelopment at Northwestern University Feinberg School of Medicine, discusses a recent discovery of a schizophrenia biomarker and how this research could one day offer earlier diagnosis, more precise treatment, and better outcomes for patients.  Learn more about how the field of neurodevelopmental research has evolved over the past decade with major advances in genetics, brain imaging and laboratory models. Large genomic studies have uncovered many more genes associated with risk of developing autism, schizophrenia and related conditions, while new technologies, including brain organoids grown from patients' stem cells, are giving scientists new insight into how these disorders develop and affect brain function.

Jeff Dudan's free digital copy of his book What if the way you've been thinking about aging, fitness, testosterone, supplements, and even going public with your company is completely wrong? In this episode, Jeff Dudan sits down with Anthony Geisler - founder of Sequel Brands and the visionary behind Club Pilates and the Exponential Fitness empire - to unpack the truth about longevity, boutique fitness franchising, and what it really takes to build a business that outlasts adversity. Anthony shares his personal biohacking protocol, why he naturally maintains testosterone levels of 800-900 at age 50 without TRT, the real reason he holds multiple gym memberships, and how Gary Brekka's longevity science is reshaping what's possible for human lifespan. They also go deep on what going public actually feels like - including the day it became illegal to operate gyms in the United States while the company was mid-IPO - and why Anthony believes the private market gives founders something public markets never can: the ability to be masters of their own destiny. Plus, the inspiring story of a Pilates instructor with three failing studios on the verge of closing who is now on track for a $200-300 million exit. Topics covered: • Genetic methylation testing and biomarker blood panels • Natural testosterone optimization without TRT or peptides • Why muscle mass is a longevity metric, not an aesthetic one • Sauna data: 50% reduction in all-cause mortality • Red light therapy, Body20 EMS, and the Sequel Brands ecosystem • Club Pilates, Exponential Fitness, and taking a company public during COVID • The Russell 2000 and the hidden costs of public market valuations • Building franchisee loyalty and supporting humans through adversity • The shift in alcohol culture and the rise of clean eating • Gary Brekka's circadian rhythm protocols and biological age reversal  Guest: ANTHONY GEISLER  Guest YouTube: https://www.youtube.com/@Anthony.Geisler/featured  Guest Business YouTube: Guest Website: https://sequelbrands.com/  Guest Socials: https://www.linkedin.com/company/sequel-brands/    #Longevity #Biohacking #FranchiseBusiness #AnthonyGeisler #SequelBrands #ClubPilates #GaryBrekka #MensHealth #Testosterone #BoutiqueF fitness Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode of Everyday Epigenetics: Raw. Real. Relatable., Susan Robbins is joined by renowned expert lipidologist Dr. Tom Dayspring for Part 1 of a special two-part series on genetically driven lipid disorders. Together, they explore phytosterolemia (formerly known as sitosterolemia), a little-known but potentially serious genetic condition that affects how the body absorbs and processes plant sterols. While often overlooked in conventional healthcare, this disorder can contribute to elevated cholesterol markers, cardiovascular risk, xanthomas, kidney issues, and other health concerns when left undetected.Dr. Dayspring breaks down the complex science of cholesterol absorption, plant sterols, and the ABCG5 and ABCG8 genes in a way that is easy to understand. Susan shares what she has observed through years of genetic testing and coaching, including how frequently she is seeing these gene variants appear in practice and why many people are being missed by standard testing. This conversation highlights the importance of personalized medicine, advanced lipid testing, and understanding the unique ways genetics can influence long-term health outcomes.In this episode:What phytosterolemia is and why it is often missedThe difference between cholesterol and plant sterolsHow the ABCG5 and ABCG8 genes regulate sterol absorptionWhy some people absorb significantly more cholesterol than othersThe connection between plant sterol hyper-absorption and cardiovascular disease riskWhy standard cholesterol testing may miss important cluesThe role of sitosterol and campesterol testingHow phytosterols can impact cell membranes, kidneys, joints, blood cells, and other tissuesThe difference between heterozygous and homozygous loss-of-function gene variantsWhy many patients are told their cholesterol is "fine" when deeper issues may existThe importance of ApoB, non-HDL cholesterol, and advanced lipid testingWhy some cholesterol-lowering therapies work better than others depending on geneticsHow lifestyle, nutrition, and personalized interventions can support lipid healthWhen to consider working with a lipid specialistIf you have a family history of heart disease, unexplained cholesterol elevations, or have been told your numbers are "normal" despite ongoing concerns, or if use of statins hasn't helped yu, this episode offers valuable insight into a genetic factor that is rarely discussed but can have a significant impact on long-term health.Learn more about Dr. Tom Dayspring on the website shownotes!https://healthyawakening.co/2026/06/08/episode127/RESOURCES:Connect with Dr. Tom DayspringX: https://x.com/drlipidhttps://healthyawakening.co/2026/06/08/episode127/Connect with Susan: https://healthyawakening.co/Visit the website: healthyawakening.co/podcastFind listening links here: https://healthyawakening.co/linksP.S. Want reminders about episodes? Sign up for our newsletter, you can find the link on our podcast page! https://healthyawakening.co/podcast

Lipoprotein (a) (Lp(a)) was discovered in 1963 by a Norwegian geneticist by the name of Kåre Berg who studied particles that carried cholesterol in the blood. He found some patients had an additional protein on the low-density lipoprotein. Studies found that patients with elevated Lp(a) had increased risks of cardiovascular disease. However, the levels were not affected by diet, environmental factors, or medications. The result is that this test was largely ignored for the last few decades. Recent dyslipidaemia guidelines released by the United States and Europe have returned a focus back on to Lp(a). They recommend that patients should have Lp(a) tested once throughout their life to assess their cardiovascular disease risk. The result can help identify which patients are at a higher risk of cardiovascular morbidity and mortality and who will benefit from lifestyle modification and early intervention. This resource is referenced during the discussion: https://www.lpaclinicalguidance.com/ This is the story of lipoprotein (a). Our Special Guests: Dr Michael Page is a chemical pathologist at Clinipath in Perth, senior lecturer at the UWA Medical School, and immediate past President of the AMA (WA). Listen: This Medical Life podcast is available on all podcasting services and Spotify. Members of the RACGP are able to log the hours as CPD (Education) that they listen to the episodes under self record via Quick log. We invite you to help support us on our donation page.See omnystudio.com/listener for privacy information.

Historian Kristen Theriault specializes in recent Christian persecution and joins us to share the story of Father Gabriel Romanelli – the priest of the only Catholic Church in Gaza – Holy Family. Episode Guide The Christians who remain in war-torn Gaza and what the Church means to them (0:45) Stories of the last remaining Christians in Gaza (25:29) The public abortion of Youtuber Jesse Ridgway and his wife Ashley due to down syndrome (34:30) Resources mentioned: The Priest who Stayed in Gaza https://a.co/d/0hDKJJIE Recent Gaza war news https://www.bbc.com/news/articles/cg5prr9gr1ro The lie of Genetic testing for babies exposed https://relevantradio.com/2022/01/the-lie-of-genetic-testing-for-babies-exposed/ Support and healing After Abortion https://supportafterabortion.com/

A new platform draws on the principles of genetics to supercharge inventory decisions across warehouse networks.

Is high blood pressure genetic? Are we stuck having to take blood pressure meds?Could you please critique the study asserting fish oil supplements elevate the risk of atrial fibrillation?I've had strep throat three times in two months! What gives?I've had queasy reactions to protein added foods

Adam Boyko, PhD continues his conversation on the coefficient of inbreeding (COI). This webinar focuses on genetic diversity, and addresses the balance between breeding healthy, genetically sound dogs while conforming to the breed standard. New genomic methods have advanced the way conservation geneticists think about population genetic health and provide insights into strategies for preserving and improving genetic health in dogs.Watch the video version of this presentation here.

In this episode of Genetics in Your World, GSA Early Career Scientists Multimedia Subcommittee member Racheal Asaolu has a conversation with Dr. Randall J. Roper of the School of Science at Indiana University. They discuss Roper's work. Read his paper titled, "Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice," published in the May 2026 issue of G3: Genes|Genomes|Genetics: https://doi.org/10.1093/g3journal/jkag056. Music: Loopster Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License, http://creativecommons.org/licenses/by/3.0/Thank you to the Multimedia Subcommittee, particularly the production team for this episode: Racheal Asaolu, interviewer; Shruti Shastry, Audio Quality Control Coordinator; Laetitia Chauve and Anindya Ganguly, researchers. #Trisomy21 #SkeletalDeficits #SexDifferences #MicroComputedTomography Hosted on Acast. See acast.com/privacy for more information.

There are now more grizzly bears in more places in and around Yellowstone National Park than at any time in over a century. But until this spring, the population lacked genetic diversity. Montana Public Radio's Nick Mott reports on how fresh bear genes got into Yellowstone, and what it could mean for the bears' endangered species protections.

Further reading: What gives bees their sweet tooth? Show transcript: Welcome to Strange Animals Podcast. I'm your host, Kate Shaw. Right before I left on my trip to Belize a few months ago, my aunt Janice gave me a magazine to read on the plane, the Autumn 2021 copy of LivingBird. It's about birds and birdwatching. I actually forgot to take it with me and it was in my car the whole time I was gone, but when I got home I took it in to read. One article caught my eye, titled “Investigating the Sweet Tooth of Songbirds.” Literally the same day that I read that article, I stumbled across another article on ScienceDaily titled “What gives bees their sweet tooth?” And a podcast episode idea was born! You may have heard that domestic cats can't taste sweetness, and that's true. When your pet cat wants to drink the milk in a bowl of sugary cereal, it's not the sugar they care about because they can't taste it. Also, milk isn't good for cats and even if they can't taste the sugar, it can end up giving them cavities. The question is, why don't cats taste sweetness? And what other animals can't taste it either? Carnivores like cats don't need to taste sweet flavors because it's just not present in meat, which is what carnivores eat. You can test this easily if you put two saucers on the floor for your cat, one with a small amount of unseasoned chicken and a sugar cube in the other. I guarantee you the cat will eat the chicken and play with the sugar cube, which will get sugar all over the floor so maybe don't do that after all. This is where I share with you, for no reason, that when I was in elementary school I used to eat sugar cubes while pretending I was a horse. Horses can taste sweet flavors like sugar because they're herbivores. Herbivores eat plants, and in fact herbivores have a whole lot of taste buds so that they can easily tell what kind of plants they're eating. Bitter tasting plants might be toxic while sweet ones provide lots of energy. Herbivores are also keenly attuned to the taste of salt since their diet is typically low in salt and they need to seek it out. Humans are omnivores, and omnivores eat pretty much anything. Like our great ape cousins, we also evolved to eat a lot of fruit. Ripe fruit tastes sweet so we really like our sweet foods. Omnivores like dogs, pigs, and bears also like sweet foods because they're high in calories and therefore provide a lot of energy. But how does an animal lose an entire sense of taste? It's not like all tigers woke up one day and boom, the ability to taste sweetness was gone. It happens gradually as the genes responsible for an animal's sense of taste mutate over many generations. Let's take as our example the bottlenose dolphin. The ancestors of the dolphin and other cetaceans were terrestrial animals related to the ancestors of modern even-toed ungulates like hippos, camels, deer, and pigs, and were probably either herbivores or omnivores. But as the dolphin's ancestors evolved over millions of years, they shifted to a fully marine lifestyle and a fully carnivorous diet. Over the thousands and thousands of generations, the genes that control the ability to taste sweetness mutated so much that they're now useless, but since the dolphin doesn't need to taste sweetness the mutations don't matter. In the case of the bottlenose dolphin and other cetaceans, in fact, they also can't taste bitterness or umami. Umami is what helps you taste the difference between chicken and turkey, steak and pork, tuna and trout. Basically it's the flavor of meat or savory foods, including cheeses. You can taste the difference between cheddar and Swiss because of the umami receptors in your taste buds, which are determined by genes. But the dolphin eats nothing but meat! Why would it lose the ability to taste meat? Researchers think it's because the dolphin swallows fish and other animals whole, without chewing. Cetaceans and other marine carnivores like sea lions that swallow their food whole actually have almost no taste buds at all. If you're wondering what happens when an animal that can't taste sweetness has to adapt to a diet where tasting sweet foods is important, that's exactly what happened with songbirds. The ancestors of birds lost the ability to taste sweetness millions of years ago when they were dinosaurs. Then, well, you know what happened to the non-avian dinosaurs. Suddenly the ancestors of modern birds had a lot of available ecological niches to take advantage of and they evolved rapidly to fill them. This included small birds who eat berries and nectar. Genetic studies suggest that the ancestors of songbirds regained the ability to taste sweetness around 30 million years ago in Australia. The same thing happened in hummingbirds at about the same time. In both cases, the genes that control the ability to taste umami evolved to taste sweetness instead—but songbirds and hummingbirds adapted different umami genes. That's what you call a subtle case of convergent evolution. Songbirds and hummingbirds adapted to a diet high in sugar because it's a good source of energy and easily found in flowers. In turn, flowers needed to be pollinated and have their seeds spread around, so they evolved to provide even more sugars in nectar and berries. But birds aren't the only animals that pollinate flowers and are attracted to nectar. Insects can all detect sweetness. However, bees are exceptionally attuned to sweetness and have two taste neurons instead of one per taste bud. Insects don't have taste buds the same way we do, of course. In mammals, reptiles, and birds, taste buds are located on the tongue, in a few parts of the mouth, and at the top of the throat. In insects, taste receptors can be in any number of places. They're on an insect's mouthparts but often also on their feet, legs, and antennae. Some amphibians have taste receptors on the body as well as concentrated in the mouth, and many fish have taste receptors all over their body. Catfish in particular have the most taste buds known, up to 175,000. Humans have about 10,000. Cats only have about 500. Before you start feeling sorry for your cat for not being able to taste sweet foods and not having a great sense of taste in general, cats have a taste receptor we don't. It's the water sense. To us, a nice cold glass of water tastes refreshing but doesn't really have a flavor. A cat or dog, and many other animals whose diet is mostly meat even if they aren't specifically carnivores, have the ability to taste water in a way we can't even imagine. Because meat is high in salt content, having taste buds attuned to water helps the animal drink enough water to process all that salt. If you gave me the choice, I'd choose sweetness over the ability to taste water. But my cats would probably disagree. Thanks for your support, and thanks for listening!

Send a Text Message. Please include your name and email so we can answer you! Please note, this does not subscribe you to our email list, it's just to answer if you have a questions for us. As women, so much of our identity is tied to our hair. And when it starts to fall out, the internet will sell you a thousand solutions before anyone stops to ask why.In this episode, I'm joined by Dr. Komal Patil-Sisodia — triple board-certified endocrinologist, hormone expert, and someone who has lived this firsthand. Stress-related shedding in med school. Postpartum loss. Genetic thinning. She's been through every stage, and she's here to help you finally get some answers. We get into the real hormonal and metabolic causes, the labs worth asking for, and why addressing the root cause will always matter more than the next serum, supplement, or device in your feed. ReferencesFolly Nutrition Hair Health Gummies (Use code MATTHEA)Connect with Dr. Komal Patil-Sisodia:Instagram/TikTok: @drpatilsisodiaPodcast: Clearly HormonalPractice: Eastside Menopause and MetabolismGet the free podcast roadmap for The Obesity GuideSubscribe to my Youtube channelAll of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast. If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com Not Sure Where to Start With the Podcast? I've Got You.Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.Support the show

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The DNA recovered from Nancy Guthrie's Tucson home is at the FBI lab in Quantico. Genetic genealogy is reportedly being run. And the person who allegedly took this eighty-four-year-old woman from her home months ago has no way of knowing when that process will produce a name — only that it eventually can. Psychotherapist Shavaun Scott brings more than three decades of forensic mental health experience to Hidden Killers Live for a deep psychological analysis of the person at the center of this case. Not the evidence. Not the investigation. The mind. Scott explains the difference between facing traditional investigative pressure — a tip, a witness, a mistake you can anticipate — and facing a technology that is working toward you on an invisible timeline. She examines what months of post-crime silence do to someone's ability to function, how the near-miss psychology of watching your own name potentially sit in a tip line without consequence changes behavior going forward, and whether the alleged involvement of a co-conspirator creates stability or a ticking clock of mutual fear. A retired detective has said the suspect's name is likely already somewhere in the more than fifty thousand tips submitted. Scott breaks down what that reality — being in the system but not yet found — does to a guilty mind.Footer Links:Join Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1Instagram https://www.instagram.com/hiddenkillerspod/Facebook https://www.facebook.com/hiddenkillerspod/Tik-Tok https://www.tiktok.com/@hiddenkillerspodX Twitter https://x.com/TrueCrimePodDisclaimer:This publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.Hashtags:#NancyGuthrie #SavannahGuthrie #HiddenKillersLive #GeneticGenealogy #ShavaunScott #ForensicPsychology #Tucson #FBI #TrueCrime #PerpPsychology

This week, we get into 2009's Splice, a film about fucking your genetically-modified flipper baby. Adrien Brody is at his most emo, and his bitch wife ruins science because she has mommy issues. What a mess! A sexxxxxy mess! Let's go! Sneaky scientist's unsanctioned ‘speriment spawns sentient, slippery, and seductive succubus! Genetic lumps of gene-producing goo! Course-change characters! First-person birth canals! Fleshy wieners and slimy ding-dongs! The only two goo-producing wieners in town! Inseminated uterus bots! Jack doritos! Rogue elements in the junk jeans! Clive's gooey two-shoes! Shiny scorpion stabbers! Going back to the Dren den! Concentrated secretions! Paying pregnant people to pop out penis persons! Giving the flying fish woman his slippery digit, and much, much more on this week's episode of The Worst Movie Ever Made! www.theworstmovieevermade.com

Modern genetics has enabled the connection of individuals separated by circumstance. On this episode, Alex Blum discussed his memoir, An Accident of Birth.

Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) testedWhat a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person datasetWhy the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat aloneThe simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular riskBy the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.Thank you to our sponsors:OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYONBodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.Explore More from Dr. Gabrielle LyonPremium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon's clinical team https://drgabriellelyon.com/new-patient-inquiry/Find Dr. Kevin Maki at:Midwest Biomedical Research: https://www.mbclinicalresearch.com/ LinkedIn: / kevin-c-maki-phd-497ba34 Connect with Dr. Gabrielle Lyon:Instagram: https://www.instagram.com/drgabriellelyon/TikTok: @drgabriellelyon X (Twitter): https://x.com/drgabriellelyonFacebook: https://www.facebook.com/doctorgabriellelyon Chapters00:00 - Introduction00:31 - Dr. Kevin Maki and the National Lipid Association01:04 - New dietary guidelines and the LDL confusion02:04 - What raises and lowers LDL cholesterol03:51 - Cholesterol levels from birth through puberty05:11 - The lipid panel kids should get before age 1106:42 - Lp(a): the test only 2% of people get08:18 - ApoB and the three risky particle types11:35 - Do we have evidence for "lower is better"?14:09 - The FLASH-GLICK risk factor framework17:10 - The 10% saturated fat guideline explained19:36 - Many dietary patterns can be healthy24:50 - Beef vs. chicken: identical LDL results27:10 - The balance of fatty acids that matters29:24 - Olive oil vs. corn oil feeding study31:00 - Lower for longer: 40-year risk reduction34:15 - Genetic cholesterol disorders and risk40:33 - The omega-3 index and why it matters49:10 - Are seed oils really driving inflammation?53:11 - How seed oils are processed and refined1:07:48 - Inherited beliefs and outdated nutrition science1:08:54 - Butter vs. cheese and high-fat dairy surprises1:14:48 - Exercise effects on HDL and triglycerides1:21:20 - The ABCs of reducing cardiovascular riskIf you found this episode valuable, share it with someone who would benefit from it.Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

What can we learn from a study about the genetic diversity of the few remaining pockets of Bighorn sheep in Idaho?

An intentional act of kindness, according to research and the Word of God, is literally life-changing, by God's design. How does kindness affect brain circuitry or genes? How do we impact each other with kindness? What are some ideas for acts of kindness? We delve into the details…prepare to be encouraged!

Send us Fan MailHuman genetic variation in dietary fat metabolism and its implications for health & disease.TOPICS DISCUSSED:Linoleic Acid Rise: Linoleic acid now comprises 6-8% or more of energy in Western diets.Metabolic Pathways: Omega-6 linoleic acid converts to arachidonic acid and pro-inflammatory oxylipins; omega-3 ALA converts via shared enzymes to EPA/DHA with anti-inflammatory effects.FADS Genetic Variants: Ancestry-linked haplotypes in the FADS cluster create large “pipe” size differences, altering fatty acid by up to 40% between ancestral and derived versions.Population Differences: African ancestry populations often have high-conversion “big pipe” genotypes; Indigenous American ancestry populations have low-conversion “small pipe” genotypes; European ancestry comes with a mix of both.Omega-3 Deficiency: High linoleic intake suppresses EPA production, especially in small-pipe populations, contributing to hypertriglyceridemia and fatty liver in Mexican cohorts.Clinical Evidence: Reanalysis of VITAL trial showed 83% reduction in myocardial infarction with omega-3 supplementation in African Americans; Mexican data link low EPA to unique diabetes forms.Methodological Issues: Compositional data (from GC-FID measurements) versus absolute concentration measurements can flip relationships between linoleic acid and key biomarkers.ABOUT THE GUEST: Floyd Chilton PhD is Professor and Director of the Center for Precision Nutrition and Wellness at the University of Arizona. His research focuses on functional genomics, fatty acid metabolism, and precision nutrition, particularly how genetic ancestry influences responses to dietary fats.RELATED EPISODE:M&M 291: Omega Polyunsaturated Fats & Inflammation | Philip CalderSupport the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.OmegaQuant: At-home blood testing to see fatty acid profiles, including omega-3 fatty acids. Use link to see options and support M&M.SiPhox Health: Comprehensive, cost-effective bloodwork from the comfort of home. Use code TRIKOMES for 20% off.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.For all the ways you can support my efforts

Today on Too Opinionated, we're joined by filmmaker, educator, entrepreneur, and debut novelist:

Check out BeerBiceps SkillHouse Courses Here - https://www.bbskillhouse.comFor all BeerBiceps vlog content Watch Life Of BeerBiceps - https://www.youtube.com/@LifeOfBeerBicepsCheck out my Mind Performance app: Level SuperMindLink:- https://level4665.u9ilnk.me/d/F1ZOZV4OnTShare your guest suggestions hereMail - connect@beerbiceps.comLink - https://forms.gle/aoMHY9EE3Cg3Tqdx9Join the Level Community Here:https://linktr.ee/levelsupermindcommunityFollow BeerBiceps SkillHouse's Social Media Handles:YouTube: https://www.youtube.com/@BeerBicepsSkillHouseInstagram: https://www.instagram.com/beerbiceps_skillhouseWebsite : https://beerbicepsskillhouse.inFor any other queries EMAIL: support@beerbicepsskillhouse.comIn case of any payment-related issues, kindly write to support@tagmango.comFollow Dr. Niraj Rai's Social Media Handles:-Instagram: https://www.instagram.com/nirajbiotechgju X: https://www.instagram.com/nirajbiotechgjuIn this special episode 506th of The Ranveer Show, we are joined by Dr. Niraj Rai, a leading scientist in genetics, who shares deep insights on DNA, Human Evolution, Indian Ancestry, and Health. This episode takes you into the mysteries of our genetic code, the history of Indian populations, and how our environment shapes our biology.In this conversation with Dr. Niraj Rai, we talk about the 98% Mystery DNA, the impact of inbreeding in Indian communities, the "Heart Attack Gene" specific to South Asia, and the future of CRISPR technology. We also understand how genetics can reveal our true history, from the Indus Valley Civilization to the migrations that shaped modern India.This episode also covers the Gut Microbiome, the science behind the Gotra system, the evolutionary role of proteins, and how stress and happiness affect our genetic expression. We explore the differences between ancient and modern humans and the possibility of superhuman traits hidden within us.(00:00) – Start of the episode(01:59) – Dr. Niraj Rai Returns to TRS(02:55) – The Infinite Mystery of Human DNA(05:15) – Secret of the "Warrior Clan" Proteins(08:27) – Are we 99.9% the same?(11:49) – Why Chimpanzees are 6x Stronger than Humans(14:08) – AI & the Future of Genetic Engineering(16:52) – Epigenetics: How Mood changes your Biology(19:39) – Is the Indian Genetic Code deteriorating?(21:47) – Biohacking with Stem Cells & CRISPR(25:46) – The Harsh Truth about Caste-based Inbreeding(28:30) – Why Indians are prone to Heart Attacks(32:33) – Natural Selection & Virus Outbreaks(35:52) – What did Ancient Indians really eat?(42:54) – Is Autism the next stage of Human Evolution?(47:27) – Why Humans are losing Physical Strength(51:13) – The Genetic selection for Fair Skin in India(55:26) – CRISPR: Technology to create Super-Humans(1:07:27) – Why Punjabis have "Milk-Digesting" Genes(1:11:28) – Ancient Invasions & Genetic Mixing(1:18:33) – Scientific Logic behind the Gotra System(1:22:32) – Roman & Persian DNA in South India(1:26:14) – Criminal Genes & Inherited Trauma(1:28:37) – Hypoxia Therapy for Depression(1:34:25) – End of the episode

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with Nicole Bell and Jennifer Miller from Galaxy Diagnostics about the challenges and advancements in diagnosing and treating tick-borne illnesses, particularly Lyme disease. They discuss the personal journey that led Nicole to become the CEO of Galaxy Diagnostics, the complexities of the immune response to Lyme, and the innovative diagnostic approaches being developed to improve patient outcomes. The conversation also touches on the implications of co-infections and the future of research in this critical area of health.   For Audience Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now   Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!      Takeaways ·       Nicole Bell's personal experience with tick-borne illness led her to Galaxy Diagnostics. ·       Lyme disease can be misdiagnosed, leading to severe consequences. ·       The immune response to Lyme is complex and can lead to chronic inflammation. ·       Genetic predispositions can affect how individuals respond to tick-borne pathogens. ·       Innovative diagnostic methods are being developed to improve detection of Lyme and co-infections. ·       Urine samples can be effective for diagnosing Lyme disease. ·       Co-infections like Bartonella can complicate treatment and diagnosis. ·       Early diagnosis is crucial for effective treatment of tick-borne illnesses. ·       Research is ongoing to better understand the relationship between tick-borne pathogens and mental health. ·       Galaxy Diagnostics aims to change the standard of care for tick-borne illnesses.     Chapters 00:00 Introduction to Tick-Borne Illnesses 05:04 The Journey of Diagnosis and Treatment 09:50 Understanding Lyme Disease and Its Challenges 14:53 The Immune Response and Genetic Factors 19:54 Innovative Diagnostic Approaches 24:53 Co-Infections and Their Implications 29:55 The Future of Tick-Borne Pathogen Research   To learn more about Nicole Bell/Galaxy Diagnostics:Email: nicole.bell@galaxydx.com Website: https://www.galaxydx.com/   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw       Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

 In this episode of Fertility Forward, Rena and Dara are joined by journalist and mother, Stephanie Butnick, for an honest conversation about IVF, genetic testing, and the emotional complexities of building a family. Stephanie shares how her journey with RMA began after learning her husband carries a BRCA1 mutation, and why they chose to pursue IVF with pre-implantation genetic testing. She reflects on her second IVF experience and how it differed from the first, while also opening up about the incredible support she received throughout her care. Together, they discuss what it was like for her husband to navigate these experiences as the BRCA1 carrier and how they plan to one day talk to her daughters about the journey that brought them into the world. Stephanie also shares how speaking openly about her experience has helped her connect with others facing similar challenges, emphasizing the importance of community, transparency, and keeping sight of the bigger picture throughout the fertility journey. 

Send us Fan MailWe've all heard the legend: 1588, the Spanish Armada wrecked off the coast of Galway, and Andalusian horses swimming ashore to forge the Connemara pony we know today. It's a beautiful story—but is it fact, or is it just the world's most successful marketing myth?In this episode of Connemara Pony Tales, we go "Into the Lab" with one of the world's leading equine geneticists, Dr. Samantha Brooks from the University of Florida.We move beyond the folklore to analyse the actual genomic map of the Connemara. We're putting the breed's biggest mysteries under the microscope, tackling 500 years of history and the future of the breed in one sitting.In this episode, we explore:The Ancestry Audit: Does the DNA actually show Spanish influence, or is the Connemara a "time capsule" of an even older, indigenous Irish pony?The Pony Paradox: Why does a 14.2hh mare produce a 15.1hh foal? Dr. Brooks breaks down the "growth switches" that are changing the size of our breed.The "Easy Keeper" Trap: Is the legendary hardiness that allowed our ponies to survive on the bogs now making them prone to modern metabolic crises?The Future of the Breed: Beyond HWSD—what is the next frontier of testing, and how do we protect the Connemara's famous temperament in a world demanding "Sport Horse" performance?Whether you are a traditionalist breeder or a modern performance enthusiast, this episode is a must-listen. The legends are beautiful, but the DNA tells the real story.This episode was made possible with the support of the Department of Agriculture, Food and the Marine.Support the showhttps://www.facebook.com/ConnemaraPonyWorld

  Genetic testing is no longer a distant, specialized tool reserved for rare disease clinics or academic centers. It's showing up in pediatric practice. For example, pediatricians are increasingly considering genetic diagnoses in children with developmental delays outside the normal range. A NICU graduate may already carry a genetic diagnosis when they see their pediatrician after discharge. What does the practicing pediatric provider need to understand about ordering and interpreting genetic tests?  In this episode, we unpack how community pediatricians can make sense of the world of genomics. Joining us for this robust conversation are Austin Larson, MD, and Margarita Saenz, MD. Dr. Larson is a pediatric medical and biochemical geneticist. He is the Medical Director of Precision Medicine Clinical Informatics, as well as the Director of the Mitochondrial Care Network Clinic at Children's Hospital Colorado. Dr. Saenz specializes in clinical genetics and dysmorphology. She is the Medical Director of Precision Medicine Education and Family Engagement. They both are faculty members at the University of Colorado School of Medicine. Some highlights from this episode include: Recent advances making genetic testing more accessible to patients  How the rise of exome and genome sequencing has changed the diagnostic approach in pediatrics  Secondary findings and how they should be discussed in advanced Practical advice for a pediatrician who feels overwhelmed to order and interpret these tests  For more information on Children's Colorado, visit: childrenscolorado.org. 

For decades, two women remained lost to history. Today we follow the investigative journeys that led to two Jane Does, finding their names and finding justice.Thank you to the DNA Doe Project, the Ventura County District Attorney's Office, the Ventura County Sheriff's Office, Alta, CBC, High Country News, Forensic Magazine, SF Gate, KGET News, ABC 7, A&E, KEYT News, and Wikipedia for information contributing to today's case.This episode was written by Kira McQueen, edited by John Lordan, and produced by LordanArts.Do you have any comments, or a case you'd like to suggest? You'll find a comment form and case submission link at LordanArts.com.This is not intended to act as a means of proving or disproving anything related to the investigation.  It is a conversation about the current known facts and theories being discussed.  Everyone directly or indirectly referred to is innocent until proven guilty in a court of law.LordanArts 2026

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this episode, Peter explores the complex and often misunderstood world of genetic testing, building a practical framework for understanding what these tests can and cannot actually tell us about health and disease. He explains why some genetic findings can be genuinely life-changing while many others offer information that is far more probabilistic than deterministic, and why directly measuring the phenotype is often more valuable than inferring risk from DNA alone. Peter examines where genetics can provide meaningful insight across the major disease categories and where its predictive power is far more limited than many people assume. He also discusses how to think critically about different types of genetic tests, how to interpret results in the proper context, and how to avoid the common trap of accumulating more genetic information without gaining greater clarity or actionable insight. We discuss: Genetic testing: understanding what it can reveal, where it falls short, and how to think about its clinical value [1:45]; The Human Genome Project: why decoding DNA did not immediately unlock the mysteries of disease [4:15]; The limitations of genetic testing: probabilistic risk, interpretive uncertainty, and the importance of phenotype [9:30]; Questions to ask when considering genetic testing [15:45]; Genetic testing in cardiovascular and metabolic disease: when genotype adds value beyond phenotype [17:00]; Genetic testing for inherited cardiac conditions: identifying hidden risk beyond routine screening [21:45]; Genetic testing for cancer risk: inherited syndromes, clinical utility, and the limits of consumer testing [24:00]; Genetic testing for neurodegenerative disease: risk prediction, planning, and the challenge of limited actionability [28:45]; Functional medicine genetic testing: the gap between biological plausibility and clinical evidence, and the supplement protocols that aren't supported by evidence [32:45]; Pharmacogenetics: using genetic testing to guide medication selection and safety [38:45]; A framework for evaluating genetic tests according to effect size and clinical actionability [41:45]; The major types of genetic tests, and how each should be matched to the clinical question being asked [43:30]; Interpreting genetic test results: choosing the right testing laboratory and understanding what the findings actually mean [49:45]; Framework summary: why genetic testing is most valuable when it is guided by a clear question, matched with the appropriate test, and capable of meaningfully influencing decisions [56:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Thank you for watching!~CHECK OUT ALL THE LINKS BELOW FOR THE SYNDICATE & RIOT Co.!https://link.me/breederssyndicate~SUPPORT the channel or JOIN the Discord community:https://www.buymeacoffee.com/matthewriot(This channel is not monetized - any contributions are warmly appreciated & keep us going)~QUALITY GEAR (shirts, stickers, beanies, mugs etc):https://breeders-syndicate-shop.fourthwall.com

Its Mental Health Awareness Month! This week we've got questions from Tess whose tenants burned her apartment, a writer asking about genetic testing for psych meds, and a writer who wants to know if its possible to work while in a masters program. Join our patreon!Listen ad-free, get the show a day early and enjoy the pre-show hang out on the same app you're using RIGHT NOW at www.Patreon.com/Therapy where you can also access our vast library of deep dives, interviews, skill shares, reviews and rants as well as our live discord chat!If you are an Apple user please rate us!If you are a Spotify user, please rate us!Submit a question to the show!Help us reach #1 on Goodpods!Interested in Nick's mental health approach to fitness? Check out www.MentalFitPersonalTraining.comCheck out Dr. Jim's book "Dadvice: 50 Fatherly Life Lessons" at www.DadviceBook.comGrab some swag at our store, www.PodTherapyBaitShop.comPlay Jim's Neurotic Bingo at home while you listen to the show, or don't, I'm not your supervisor.Submit questions to:www.PodTherapy.netPodTherapyGuys@gmail.comFollow us on Social Media:FacebookInstagramTwitterResources:Suicide Prevention Lifeline - 1-800-273-8255.Veterans Crisis Line - 1-800-273-8255.Substance Abuse & Mental Health Services Administration (SAMHSA) National Helpline - (1-800-662-HELP (4357)OK2Talk Helpline Teen Helpline - 1 (800) 273-TALKU.S. Mental Health Resources Hotline - 211

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan explores the powerful science of epigenetics and preconception health with Donna Gates, founder of Body Ecology. Together, they dive into the alarming rise of chronic illness in children and how a child's lifelong health may be influenced even before conception. Donna shares groundbreaking insights into the epigenetic reset that occurs in early development, offering hope that parents can help break cycles of chronic disease. The conversation highlights the critical role of detoxification, gut health, mitochondrial support, and nutrition in shaping a healthy future for the next generation. This episode is essential listening for anyone interested in fertility, generational health, functional medicine, and optimizing health before conception.

Send us Fan MailOnly 2% of Christian leaders make it to their finish line with their families, faith, and calling intact — and Doug Smith believes your health is one of the biggest reasons why. In this powerful talk, Doug shares his personal journey from "Fat Dougie" to fit at 40, the wake-up call he got from his dad's triple bypass surgery, and the practical steps every leader can take to extend their life, energy, and impact.What You'll Learn in This EpisodeWhy only 2% of Christian leaders make it to their finish line — and how to be one of themThe two questions every leader needs to answer about their health visionDoug's transformation story from overweight kid to fit at 40 (and what finally clicked)Why nutrition is 80% of the battle — and the simple food swaps that make the biggest differenceHow to use ChatGPT as a free, world-class nutrition and health coachThe "one system away" principle and how to find workouts you'll actually doWhat Function Health blood testing revealed about Doug's heart — and why every leader over 40 should "look under the hood"The hidden home toxins (mold and radon) that could be silently destroying your healthWhy lipoprotein(a) is the genetic biomarker most doctors don't test for — but shouldHow day-to-day intensity and week-to-week consistency build championsResources & Links MentionedHealth Testing & BiomarkersFunction Health Outlive by Peter Attia Dr. Mark Hyman Workouts & FitnessBeachbody / BODi Peloton Nutrition & TrackingMyFitnessPal Yuka App ChatGPT Wearables & RecoveryBevel app Books & InfluencesToday Matters by John MaxwellGlobal Leadership Summit Book Doug for your next conference or event: DougSmithLive.com⏱️ Episode Breakdown00:00 – Why health matters for leaders02:00 – The “2%” vision: finishing well04:00 – Creating a vision for your health05:00 – Where your current habits are leading07:00 – Defining health and fitness08:00 – Longevity, legacy, and stewardship11:00 – Doug's weight-loss and fitness journey14:00 – Discovering P90X16:00 – The hard conversation that changed everything17:00 – Why nutrition matters19:00 – Tracking food and using ChatGPT for accountability20:00 – Rethinking alcohol and drinks21:00 – Finding workouts you'll actually do23:00 – Consistency and daily habits24:00 – Why accountability partners help26:00 – Health scares, anxiety, and unexpected weight gain27:00 – Discovering mold exposure28:00 – Looking under the hood with bloodwork30:00 – Genetic risks and heart health31:00 – Medicine 2.0 vs. Medicine 3.032:00 – Radon, toxins, and environmental health34:00 – Tools and resources for long-term health36:00 – Start now and create a new ending37:00 – Final challenge: Don't leave your healSupport the show

What if your genes are not your destiny, but a set of clues your body has been giving you all along? In this episode, Dr. Taz sits down with Dr. Florence Comite, endocrinologist, clinician scientist, longevity expert, and author of Invincible: Defy Your Genetic Destiny to Live Better, Longer, to explore how biomarkers, genetics, hormones, sleep, metabolism, and family history shape the way we age.In this episode, Dr. Comite explains why longevity is not just about biohacking, supplements, peptides, or the latest wellness trend. Instead, she shares why true healthspan begins with understanding your own body, your own patterns, and your own family story. She explains how changes in blood sugar, fasting insulin, free testosterone, cholesterol risk ratio, sleep quality, muscle, and metabolism can reveal early signs of disease risk long before symptoms fully appear.Dr. Taz and Dr. Comite discuss why “normal” lab ranges are not always the same as optimal health, why some people begin showing signs of metabolic disease decades earlier than expected, and how family history can act as a powerful roadmap for prevention. They also explore how genetics, lifestyle, hormones, wearables, continuous glucose monitoring, sleep, movement, protein, and personalized medicine may help people change the trajectory of their future health.If you're listening to this and thinking, “I know something is off in my body, but I don't know where to start,” join the Circle here:

"What we don't know CAN really hurt us, " says Florence Comite, M.D.  Comite is a Yale University School of Medicine and National Institutes of Medicine trained physician-scientist, endocrinologist, and the leading voice in the field of precision medicine and healthy longevity. She was founder of the first global women only health center at Yale three decades ago and is founder of the Comite Center for Precision Medicine & Healthy Longevity in 2005, in New York, with satellite offices in Palo Alto and Miami Beach. Her new book, Invincible: Defy Your Genetic Destiny to Live Better, Longer, was published by Little, Brown Spark in April 2026.  Catch this week's episode of mindbodygreen podcast, created in sponsorship with Toyota. For vehicles designed for all that life has to offer, check out the 2026 RAV4, Sienna, Highlander, and Grand Highlander. Hop in, turn on the episode, and enjoy every mile.  00:00 - Aging starts in your thirties 01:55 - The decline of testosterone 07:29 - How genetics dictate aging 10:08 - Increasing testosterone  12:30 - Hormone therapy 17:59 - A DHEA story 20:37 - Metabolic markers 26:11 - Using a continuous glucose monitor 33:13 - Heart medication & testing 36:06 - Personalized medicine & prevention 39:56 - The Alzheimer's spectrum 42:38 - Genetic variables & testing 49:00 - The trouble with AI in medicine For more about Comite, visit her website: https://florencecomite.com/  Buy her book here: https://a.co/d/0cnOvaH8  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

When disaster leaves only a handful, can a civilization restart? We explore genetic bottlenecks, colony failure, and the limits of survival.Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthurWatch my exclusive video Surviving a New Ice Age: https://nebula.tv/videos/isaacarthur-surviving-a-new-ice-ageCheck out Practical Engineering: https://nebula.tv/practicalconstruction?ref=isaacarthur