Podcasts about sulfonylureas

$5 Q-BANK: https://patreon.com/highyieldfamilymedicine Intro 0:30, Diagnostic criteria 2:02, Type 1 vs type 2 diabetes 5:43, Metformin 6:57, Sulfonylureas 8:36, TZDs 9:09, DPP-4 inhibitors 9:54, GLP-1 agonists 10:39, SGLT2 inhibitors 12:39, Insulin 14:08, Diabetic ketoacidosis (DKA) 16:32, Hyperglycemic hyperosmolar syndrome (HHS) 23:07, Microvascular complications 25:06, Macrovascular complications 33:07, Practice questions 34:46

Contributor: Taylor Lynch, MD Educational Pearls: When it comes to hypoglycemia, the age dictates possible causes Neonate: Hormonal deficiency Congenital Adrenal Hyperplasia (21-hydroxylase deficiency, 11β-hydroxylase deficiency) Primary or Secondary Adrenal Insufficiency leading to cortisol deficiency  Hypopituitarism Inborn errors of metabolism Systemic infection (Under 30 days old should trigger a full infectious workup) Toddler Accidental ingestions Sulfonylureas such as glipizide or glyburide Older children Addison's Disease (Hypocortisolism) Accidential or intentional ingestions Exogenous insulin How is it diagnosed? Child or infant Glucose

Many patients with type 2 diabetes take oral antidiabetic medications, either as monotherapy or in conjunction with other oral antidiabetic medications or insulin. It's important you are able to recognize these medications as their use increases the risk of hypoglycemia, especially when taken with insulin.  This episode provides a brief overview of each of the oral antidiabetic medications with a few key things to know about each one. Sulfonylureas (ex: glipizide) Biguanides (ex: metformin) Thiazolidinediones (ex: pioglitazone/Actos) Meglitinides (ex: repaglinide) DPP-4 inhibitors (ex: sitagliptin/Januvia) Alpha-glucosidase inhibitors (ex: acarbose) SGLT2 inhibitors (ex: canagliflozin/Invokana) Dopamine agonist (ex: bromocriptine/Cycloset) ___________________ Full Transcript - Read the article and view references FREE CLASS - If all you've heard are nursing school horror stories, then you need this class! Join me in this on-demand session where I dispel all those nursing school myths and show you that YES...you can thrive in nursing school without it taking over your life! Fast Pharmacology - Learn pharmacology concepts in 5 minutes or less in this audio based program. Perfect for on-the-go review! Pharmacology Success Pack - Want to get a head start on pharmacology? Download the FREE Pharmacology Success Pack. Clinical Success Pack - One of the best ways to fast-track your clinical learning is having the right tools. This pack includes report sheets, sheets to help you plan your day, a clinical debrief form, and a patient safety cheat sheet.

Adulteration of medications of abuse is a rampant issue in the US. Most attention is on opioids; however, benzodiazepine adulteration is occurring – with sulfonylureas. Join host, Geoff Wall, as he talks about managing emergent hypoglycemia episodes.  The GameChangerSeveral case reports have detailed patients unresponsive due to severe hypoglycemia caused by mistaken sulfonylurea ingestion. Treatment of acute sulfonylurea overdose includes dextrose and octreotide.HostGeoff Wall, PharmD, BCPS, FCCP, BCGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint Health References and Resources Tucker, M. Sulfonylureas as Street Drugs: Hidden Hypoglycemia Cause. Medscape.May 2023. https://www.medscape.com/viewarticle/991680 Pharmacist Members, REDEEM YOUR CPE HERE! Not a member? Get a Pharmacist Membership & earn CE for GameChangers Podcast episodes! (30 mins/episode) CE Information Learning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Describe the phenomenon of ‘street valium' overdoses2. Discuss the treatment of severe sulfonylurea overdose 0.05 CEU/0.5 HrUAN: 0107-0000-23-227-H01-PInitial release date: 6/12/2023Expiration date: 6/12/2024Additional CPE details can be found here.Follow CEimpact on Social Media:LinkedInInstagramDownload the CEimpact App for Free Continuing Education + so much more!

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This issue will review: Dietary factors and all-cause mortality in individuals with type 2 diabetes Prevalence and Predictors of Household Food Insecurity and Supplemental Nutrition Assistance Program Use in Youth and Young Adults With Diabetes Association of Sodium–Glucose Cotransporter-2 Inhibitors with Time to Dementia Concomitant Use of Sulfonylureas and beta-Blockers with the Risk of Severe Hypoglycemia Among Patients With Type 2 Diabetes A novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: A Phase 1b Trial Different Types of Industry- Produced and Ruminant Trans Fatty Acid Intake and Risk of Type 2 Diabetes For more information about each of ADA's science and medical journals, please visitwww.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

Getting into the drug classes used to treat diabetes. We start off with those that increase the secretion of insulin -  Sulfonylureas and Meglitinides. These drugs get to their site of action and stimulate our bodies to release more insulin to gobble up the glucose, as a result blood sugar levels are controlled.  

This episode covers sulfonylureas!

Contributor: Cheyenne Bean, PharmD Educational Pearls: Bactrim (TMP-SMX) is a sulfa antibiotic used for a number of infections but can have untoward effects. Hypoglycemia can be induced by the sulfa component of Bactrim, which binds receptors in the pancreas causing insulin to be secreted, dropping blood sugar levels. Oral diabetic medications, specifically sulfonylureas, when taken with Bactrim most often lead to these hypoglycemic episodes. Hyperkalemia can be induced by Trimethoprim by blocking potassium excretion in the kidney, so Bactrim in combination with ACE inhibitors/ARBs/spironolactone can induce high potassium. When prescribing Bactrim, remember to check home medications and if a patient is taking an above medication, check a baseline BGL and potassium. References 1) Khorvash F, Moeinzadeh F, Saffaei A, Hakamifard A. Trimethoprim-sulfamethoxazole Induced Hyponatremia and Hyperkalemia, The Necessity of Electrolyte Follow-up in Every Patient. Iran J Kidney Dis. 2019 Jul;13(4):277-280. PMID: 31422395. 2) Kennedy KE, Teng C, Patek TM, Frei CR. Hypoglycemia Associated with Antibiotics Alone and in Combination with Sulfonylureas and Meglitinides: An Epidemiologic Surveillance Study of the FDA Adverse Event Reporting System (FAERS). Drug Saf. 2020 Apr;43(4):363-369. doi: 10.1007/s40264-019-00901-7. PMID: 31863282; PMCID: PMC7117991. Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at www.emergencymedicalminute.com/cme-courses/ and create an account. 

Contributor: Dylan Luyten, MD Educational Pearls: Insulin related hypoglycemia can vary from a brief transient effect from short-acting forms (i.e. insulin lispro) to prolonged from long acting (i.e. insulin glargine), and will require different treatment and/or observation Of oral glycemic agents, sulfonylureas are a common culprit while metformin is rarely a cause Sulfonylureas also deserve attention because in pediatric patients, they can be lethal even with a single ingestion, but also can cause severe hypoglycemia in adults Hypoglycemia in non-diabetics usually occurs in the malnourished, or in those with liver or adrenal disease References Klein-Schwartz W, Stassinos GL, Isbister GK. Treatment of sulfonylurea and insulin overdose. Br J Clin Pharmacol. 2016;81(3):496–504. doi:10.1111/bcp.12822 Tourkmani AM, Alharbi TJ, Rsheed AMB, AlRasheed AN, AlBattal SM, Abdelhay O, Hassali MA, Alrasheedy AA, Al Harbi NG, Alqahtani A. Hypoglycemia in Type 2 Diabetes Mellitus patients: A review article. Diabetes Metab Syndr. 2018 Sep;12(5):791-794. doi: 10.1016/j.dsx.2018.04.004. Epub 2018 Apr 12. Summarized by Will Dewispelaere, MS4 | Edited by Erik Verzemnieks, MD

In this episode, Dr. Madrid discusses commonly prescribed medications which can cause and contribute to weight gain. Is it possible your doctor is contributing to your weight gain? Dr. Madrid also discusses some alternatives to these medications. Diabetes drugs which cause weight gain: 1. Insulin- Long acting and short acting formulations 2. Thiazolidinediones. – rosiglitazone, poglitazone (actos) 3. Sulfonylureas – glipizide, glimepiride and glyburide Alternatives? Metformin, Liraglutide and dulaglutide can assist with weight loss Depression/Anxiety: 1. Antidepressant drugs like amitriptyline, paroxetine, sertraline and mirtazapine (Remeron) frequently cause weight gain.. *Alternatives to ask your doctor about include reducing the dose of the medication, especially if it is working for you. Some find that fluoxetine, and buproprion (Wellbutrin) help with weight loss. St. Johns wort is an herbal equivalent with no affect on weight. Blood pressure-reducing drugs: 1. beta-blockers (metoprolol, atenolol, carvedilol) slow down metabolism/heart rate, and increase weight. Alternatives: ace inhibitors, ARBs and Calcium Channel blockers. Seizure disorders/epilepsy drugs; 1. Valproate and carbamazepine Steroid hormone drugs: 1. Prednisone and birth control pills are associated with weight gain. Inhaled steroids, used for asthma/copd is not associated with weight gain. Bipolar and schizophrenia drugs: Antipsychotic drugs such as haloperidol, clozapine, lithium, dulaglutide and liraglutide. Instagram: @ericmadridmd Twitter: @ericmadridmd Facebook: facebook.com/ericmadridmd DISCLAIMER: This podcast is not intended to provide a diagnosis, treatment or medical advice. Opinions by Dr. Madrid are for INFORMATIONAL purposes only. Please consult with your physician regarding your situation as each person is unique.

Sulfonylureas are an older, cheaper class of medication that is used to stimulate insulin secretion and lower blood sugar.  I discuss the pharmacology and what to look out for in real life practice.  

Episode 3 - Insulin secretagogues: sulfonylureas & glynides(Guest: Dr. Mark Feinglos) by DukeWELL

Learning Objectives:  Review the data on the risks of SU use Consider other second line approaches to Type 2 DM Review Primary Treatment Goals for T2DM

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 15 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: 1. Sulfonylureas and Risk of CV events and Hypoglycemia 2. The Gap between Clinical Trials and Real World Effectiveness of Medications 3. The Role of Hyperglycemia on Cognitive Performance 4. Pioglitazone Improves Left Ventricular Diastolic Function 5. GLP-1 Levels post Gastric Bypass Mediate Response to Food Cues 6. Influence of Breakfast on Gene Experession and Effect on Postprandial Glycemic Response For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil S. Skolnik, M.D., Professor of Family and Community Medicine, Temple University School of Medicine; Associate Director, Family Medicine Residency Program, Abington Memorial Hospital. John J. Russell, M.D., Associate Professor of Family and Community Medicine, Temple University School of Medicine; Director, Family Medicine Residency Program, Abington Memorial Hospital.

This week, Amol, general internal resident at the University of Toronto, and Reena, General Internist at St. Michael's Hospital in Toronto, discuss two papers: Reena shares a large registry-based study that found adult patients with Type 2 Diabetes in Sweden had a 15% higher mortality rate than the general population. Amol and Reena wonder why this ... The post Diabetes Week: Mortality in Diabetes and DPP-4 Inhibitors Compared to Sulfonylureas appeared first on Healthy Debate.

This week, Amol, general internal resident at the University of Toronto, and Reena, General Internist at St. Michael's Hospital in Toronto, discuss two papers: Reena shares a large registry-based study that found adult patients with Type 2 Diabetes in Sweden had a 15% higher mortality rate than the general population. Amol and Reena wonder why this ...The post Diabetes Week: Mortality in Diabetes and DPP-4 Inhibitors Compared to Sulfonylureas appeared first on Healthy Debate.

Interview with Christianne L. Roumie, MD, MPH, author of Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabetes