Podcasts about pmid

Today Eric tells Alex all about reincarnation. This is a topic that has fascinated Eric for a long time. Did Eric actually stump Alex on this supernatural phenomena.References:: https://www.britannica.com/topic/Orphic-religionhttps://en.wikipedia.org/wiki/San%C4%81tana_Dharmahttps://vedanta-seattle.org/articles/hindu-concept-of-reincarnation/https://buddhismzone.org/how-does-reincarnation-happen/#:~:text=The%20process%20of%20reincarnation%20in%20Buddhism%20links%20to,This%20is%20what%20Buddhists%20refer%20to%20as%20nirvana.Stevenson I. American children who claim to remember previous lives. J Nerv Ment Dis. 1983 Dec;171(12):742-8. doi: 10.1097/00005053-198312000-00006. PMID: 6644283.https://uvamagazine.org/articles/the_science_of_reincarnationhttps://www.britannica.com/topic/Manichaeismhttps://www.britannica.com/topic/gnosticismhttps://www.learnreligions.com/children-remember-past-lives-1731359https://youtu.be/r4wkPDBuWV0https://med.virginia.edu/perceptual-studies/our-research/children-who-report-memories-of-previous-lives/https://www.psychologytoday.com/us/blog/the-seekers-forum/202207/when-children-remember-past-lives

Citado en el podcast: - Cursos en comiendoconmaria: https://www.comiendoconmaria.com/cursos/- Primera visita con Asier y/o Ester: https://www.comiendoconmaria.com/primera-visita-equipo/- Artículo de El País: https://elpais.com/salud-y-bienestar/2022-11-24/mas-intensidad-con-menos-tiempo-dos-estudios-podrian-cambiar-las-recomendaciones-de-ejercicio-fisico-como-medicina-preventiva.html- Estudio sobre qué ejercicio es mejor realizar: Zhou Y, Wu W, Zou Y, Huang W, Lin S, Ye J, Lan Y. Benefits of different combinations of aerobic and resistance exercise for improving plasma glucose and lipid metabolism and sleep quality among elderly patients with metabolic syndrome: a randomized controlled trial. Endocr J. 2022 Jul 28;69(7):819-830. doi: 10.1507/endocrj.EJ21-0589. Epub 2022 Feb 22. PMID: 35197411.- Podcast 222 de Cristina Mitre: http://www.thebeautymail.es/entrenamiento-de-fuerza-inaky-garcia-episodio-222/

In this week's episode Gary and Will discuss their Thanksgiving along with a study by Ott et al (PMID: 29378051) where participants were fed 1,000 calories over their maintenance every day for 7 days straight. The results may surprise you! Thanks for listening! Join our free Facebook community "Fat Loss Secrets For Busy Adults" for guides, recipes, meal templates, giveaways, and more! Check it out and join here: https://www.facebook.com/groups/fatlosssecretsbusyadults

Dr. Laura Certain (@laura_certain) and Dr. Nico Cortes-Penfield (@Cortes_Penfield) join Dr. Julie Ann Justo (@julie_justo) to discuss all things related to prosthetic joint infections. Tune in to learn about what comprises a bacterial biofilm, how it develops, and ways to combat it using the latest evidence-based antibiotic regimens. We also take a look at what's on the horizon for the field of orthopedic infectious diseases. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/ References: Cortés-Penfield NW, Kulkarni PA. The History of Antibiotic Treatment of Osteomyelitis. Open Forum Infect Dis. 2019 Apr 8;6(5):ofz181. doi: 10.1093/ofid/ofz181. PMID: 31123692. Bernard L, et al. Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection. N Engl J Med. 2021 May 27;384(21):1991-2001. doi: 10.1056/NEJMoa2020198. PMID: 34042388. (DATIPO trial) Gallagher C, et al. Impact of Implementing an IV to PO Antibiotic Treatment Protocol for Orthopedic Infections ion Prescribing Habits and Health Utilization Outcomes. IDWeek 2022. Poster 909. Febrile Podcast. Episode #31 – Truth or DAIR. 2022 Feb 28. https://febrilepodcast.com/episode-31-truth-or-dair/ Frank JM, et al. The Mark Coventry, MD, Award: Oral Antibiotics Reduce Reinfection After Two-Stage Exchange: A Multicenter, Randomized Controlled Trial. Clin Orthop Relat Res. 2017 Jan;475(1):56-61. doi: 10.1007/s11999-016-4890-4. PMID: 27387759. Kelly MP, et al. Extended Oral Antibiotics Increase Bacterial Resistance in Patients Who Fail 2-Stage Exchange for Periprosthetic Joint Infection. J Arthroplasty. 2022 Aug;37(8S):S989-S996. doi: 10.1016/j.arth.2022.01.027. PMID: 35074446. Payne J, et al. Inducing Antimicrobial Resistance with Long-term Antibiotics at Stage 2 Revision for Periprosthetic Joint Infection. IDWeek 2022. Poster 981. Frost P, et al. Phototoxic potential of minocycline and doxycycline. Arch Dermatol. 1972 May;105(5):681-3. PMID: 5026677. Lode H, et al. Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, and CGP 9000. Antimicrob Agents Chemother. 1979 Jul;16(1):1-6. doi: 10.1128/AAC.16.1.1. PMID: 475366. Sader HS, et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. Diagn Microbiol Infect Dis. 1993 Aug-Sep;17(2):143-50. doi: 10.1016/0732-8893(93)90025-3. PMID: 8243035. Green S & Tsai YV. Precision Dosing of To-Marrow: Linezolid Therapeutic Drug Monitoring. ContagionLive: Bench to Bedside with SIDP. 2022 Nov 3. https://www.contagionlive.com/view/precision-dosing-of-to-marrow-linezolid-therapeutic-drug-monitoring Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints.

CUPOM: BLACKFRIDAYGUIA www.tadeclinicagem.com.br/guia - Conheça o Guia TdC com 7 dias grátis Um serviço de revisão e atualização continuados em clínica médica. A informação que você precisa, do jeito que você prefere. Junte-se aos mais de 800 assinantes. Assine o Guia, ganhe tempo e atualize-se sem esforço. Joanne, Kaue e Lucca conversam sobre armadilhas no tromboembolismo pulmonar (TEP): Quando pedir d-dímero e ajuste, em que momento iniciar a anticoagulação, como fazer a estratificação, quando trombolisar, qual anticoagulante iniciar, anticoagular ou não o TEP subsegmentar/assintomático e um pouco de TEP na gestante. Referências: 1. Kahn SR, de Wit K. Pulmonary Embolism. N Engl J Med. 2022 Jul 7;387(1):45-57. doi: 10.1056/NEJMcp2116489. PMID: 35793208. 2. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Respir J 2019; 54. 3. Raja AS, Greenberg JO, Qaseem A, et al. Evaluation of Patients With Suspected Acute Pulmonary Embolism: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med 2015; 163:701. 4. Stevens SM, Woller SC, Kreuziger LB, et al. Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report. Chest 2021; 160:e545. 5. Kucher N, Goldhaber SZ. Management of massive pulmonary embolism. Circulation 2005; 112:e28. 6. Aujesky D, Obrosky DS, Stone RA, et al. A prediction rule to identify low-risk patients with pulmonary embolism. Arch Intern Med 2006; 166:169. 7. Becattini C, Casazza F, Forgione C, et al. Acute pulmonary embolism: external validation of an integrated risk stratification model. Chest 2013; 144:1539. 8. Righini M, Van Es J, Den Exter PL, Roy PM, Verschuren F, Ghuysen A, Rutschmann OT, Sanchez O, Jaffrelot M, Trinh-Duc A, Le Gall C, Moustafa F, Principe A, Van Houten AA, Ten Wolde M, Douma RA, Hazelaar G, Erkens PM, Van Kralingen KW, Grootenboers MJ, Durian MF, Cheung YW, Meyer G, Bounameaux H, Huisman MV, Kamphuisen PW, Le Gal G. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA. 2014 Mar 19;311(11):1117-24. doi: 10.1001/jama.2014.2135. Erratum in: JAMA. 2014 Apr 23-30;311(16):1694. PMID: 24643601. 9. Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, Hutten BA, Jaff MR, Manja V, Schulman S, Thurston C, Vedantham S, Verhamme P, Witt DM, D Florez I, Izcovich A, Nieuwlaat R, Ross S, J Schünemann H, Wiercioch W, Zhang Y, Zhang Y. American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism. Blood Adv. 2020 Oct 13;4(19):4693-4738. doi: 10.1182/bloodadvances.2020001830. PMID: 33007077; PMCID: PMC7556153. 10. Duffett L, Castellucci LA, Forgie MA. Pulmonary embolism: update on management and controversies. BMJ. 2020 Aug 5;370:m2177. doi: 10.1136/bmj.m2177. PMID: 32759284. 11. van der Hulle T, Cheung WY, Kooij S, Beenen LFM, van Bemmel T, van Es J, Faber LM, Hazelaar GM, Heringhaus C, Hofstee H, Hovens MMC, Kaasjager KAH, van Klink RCJ, Kruip MJHA, Loeffen RF, Mairuhu ATA, Middeldorp S, Nijkeuter M, van der Pol LM, Schol-Gelok S, Ten Wolde M, Klok FA, Huisman MV; YEARS study group. Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study. Lancet. 2017 Jul 15;390(10091):289-297. doi: 10.1016/S0140-6736(17)30885-1. Epub 2017 May 23. Erratum in: Lancet. 2017 Jul 15;390(10091):230. PMID: 28549662.

Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. In this episode, we'll explore a topic that we're sure many listeners are eager to learn about: The Assessment of Major Neurocognitive Disorder, also known as dementia with Dr. Lesley Wiesenfeld who is a Geriatric Psychiatrist and Psychiatrist-in-Chief at Mount Sinai Hospital in Toronto, where she leads the Geriatric Consult Liaison Psychiatry Service. She is also an Associate Professor in the Department of Psychiatry at the University of Toronto.   The learning objectives for this episode are as follows:   Define Major Neurocognitive Disorder (aka Dementia) as per DSM-5 diagnostic criteria Identify differential diagnoses for cognitive decline and list differentiating clinical features  Outline an approach to the assessment of a patient presenting with cognitive decline, including the role of a comprehensive history, psychometric tools and other investigations [ Relevant PMH/risk factors, ADLs/IADLs to cover on history, psychometric tools such as MMSE, MoCA and tie this back into major cognitive domains when to consider imaging, bloodwork including specialized testing such as ApoE genetic tests]  Classify the major subtypes of Neurocognitive Disorders, their epidemiology, and clinical presentations [ Vascular dementia, Alzheimer's, Frontotemporal, Lewy Body, Parkinson's,    Mixed dementia - Early onset dementia]   Guest: Dr. Lesley Wiesenfeld ( Lesley.Wiesenfeld@sinaihealthsystem.ca )   Hosts: Dr. Luke Fraccaro (PGY-3), Dr. Mark Fraccaro (PGY-4), Sena Gok (international medical graduate)   Audio editing by: Sena Gok   Show notes by: Sena Gok   Interview Content: Introduction: 0:13 Learning Objectives: 02:35 Diagnostic criteria of Major Neurocognitive Disorder: 03:20 Difference between Major and Mild Neurocognitive Disorder: 05:20 Red Flags of Cognitive Declines: 06:50 Normal Aging vs Major Neurocognitive Disorder: 10:00 Clinical Vignette – introduction: 11:35 Patient Assessment: 16:50 Past medical/family / Psychosocial history: 21:55 Clinical Vignette - Assessment: 37:45 Physical examination: 43:50 Investigations: 45:53 Role of genetic testing: 53:24 Clinical Vignette – Diagnosis: 57:50   References:   American Psychiatric Association. (2022). Neurocognitive Disorders. In Diagnostic and statistical manual of mental disorders (5th ed., text rev.).   Sadock, B. J., Sadock, V. A., Ruiz, P., & Kaplan, H. I. (2015). Neurocognitive Disorders. Kaplan and Sadock's Synopsis of Psychiatry (11th ed.). Wolters Kluwer   DSM-5-TR Fact Sheets (https://psychiatry.org/psychiatrists/practice/dsm/educational-resources/dsm-5-tr-fact-sheets )   Gauthier S, Patterson C, Chertkow H, Gordon M, Herrmann N, Rockwood K, Rosa-Neto P, Soucy JP. Recommendations of the 4th Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD4). Can Geriatr J. 2012 Dec;15(4):120-6. doi: 10.5770/cgj.15.49. Epub 2012 Dec 4. PMID: 23259025; PMCID: PMC3516356.   Gauthier S, Chertkow H, Theriault J, Chayer C, Ménard MC, Lacombe G, Rosa-Neto P, Ismail Z. CCCDTD5: research diagnostic criteria for Alzheimer's Disease. Alzheimers Dement (N Y). 2020 Aug 25;6(1):e12036. doi: 10.1002/trc2.12036. Erratum in: Alzheimers Dement (N Y). 2022 Feb 03;6(1):e12088. PMID: 32864413; PMCID: PMC7446944. CPA Note: The views expressed in this podcast do not necessarily reflect those of the Canadian Psychiatric Association.   For more PsychEd, follow us on Twitter (@psychedpodcast), Facebook (PsychEd Podcast), and Instagram (@psyched.podcast). You can provide feedback by email at psychedpodcast@gmail.com. For more information, visit our website at psychedpodcast.org.

Episode 120: Immune Reconstitution Inflammatory Syndrome (IRIS) Abeda Faharti and Dr. Schlaerth present the definition, diagnosis, and treatment of IRIS. Moderated by Dr. Arreaza. Written by Abeda Farhati, MS4, Ross University School of Medicine. Editing and comments by Katherine Schlaerth, MD, and Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition.Have you heard of IRIS? No, not the color portion of our eyes. IRIS is short for Immune Reconstitution Inflammatory Syndrome. This condition occurs in immunocompromised patients with HIV/AIDS due to an overactive inflammatory response. In most cases, it occurs after initiating antiretroviral therapy (ART). To understand IRIS in HIV patients, we must first understand HIV.HIV.The Human Immunodeficiency Virus (HIV) infection was first reported in 1981. The virus attacks the immune system, destroying white blood cells called CD4+ T lymphocytes, which are part of our body's defense mechanism. These cells are also known as "helper T cells" and are responsible for destroying viruses, bacteria, and other germs that make us sick.When your CD4+ count is low, you are more likely to get serious infections from viruses, bacteria, and fungi, which usually do not cause problems in otherwise healthy individuals. These infections are called Opportunistic infections, and they can be deadly. To restore CD4+ T lymphocytes, HIV patients are started on ART to normalize their immune response to pathogens. As a result of these treatments, HIV patients' lives have been significantly improved and prolonged. [Comment by Dr. Arreaza: It is paradoxical, but some HIV patients are among the healthiest patients I have seen.]Despite this, no treatment is guaranteed to be without side effects. Increases in CD4+ T lymphocytes trigger the immune system to respond to any persisting antigen, regardless of whether it is fragments or intact organisms. As a result, a hyperinflammatory response may occur.Diagnosis.There are no established criteria for diagnosing IRIS. It is generally accepted that IRIS requires the worsening of an existing infection or an unrecognized, preexisting infection in the context of improved immune function. For a diagnosis to be made, most, if not all of the following features must be present:The presence of a low CD4 count (less than 100 cells) before initiating treatment with ART (Except IRIS secondary to preexisting TB infection can occur with CD4 counts >200 cells).The presence of an inflammatory condition, especially after ART is initiated.The absence of drug-resistant infection, bacterial superinfection, drug allergy, or other adverse drug reactions.The absence of patient noncompliance or reduced drug levels due to drug-drug interactions or malabsorption.Clinical Manifestations.IRIS can be presented in patients in 2 ways:Patient's with a preexisting infectious disease that has NOT been treated, getting paradoxically worse after initiating treatment with ART ---this is known as “unmasking IRIS” ORPatient's with a preexisting infectious disease that has been previously diagnosed and treated but regained capacity after treatment with ART, causing it to mount an inflammatory response – this is known as “paradoxical IRIS.”In summary: Unmasking IRIS and paradoxical IRIS.Patients with IRIS have clinical features that vary widely. The presentations are strongly dependent on the type of preexisting opportunistic infection. For example, about 75% of patients with a mycobacterial or cryptococcal-related infection will develop a fever. In contrast, fever is rarely seen in cytomegalovirus (CMV) infections.Risk & Prevention.Researchers have found that lower CD4 cell counts or high HIV RNA levels at the time of anti-retroviral treatment initiation increase the risk of developing IRIS. One way to prevent IRIS development is to treat opportunistic infections prior to starting ART. Although this reduces the risk of IRIS development, it does not guarantee it.Treatment.In “unmasking IRIS,” patients can be treated with antibiotics, antivirals, or antifungals against the underlying infectious organism. In severe cases, steroids can also be used to suppress inflammation until the infection has been eradicated. Unfortunately, there is no treatment for paradoxical IRIS. Most patients who experience “paradoxical IRIS” reactions will get better spontaneously without additional therapy.Incidence of IRIS.The overall incidence of IRIS is unknown; however, studies have shown that anywhere from 25 to 30% of HIV patients who start antiretroviral treatment develop IRIS in the first six months. You may ask, which preexisting infections can lead to patients developing IRIS?Pathogens associated with IRIS.Different pathogens have been associated with the development of IRIS. The leading pathogens include:Mycobacterium tuberculosisMycobacterium avium complexCytomegalovirusCryptococcus neoformansPneumocystis jiroveciiHerpes simplex virusHepatitis B virusHuman herpes virus 8 (associated with Kaposi sarcoma)Non-HIV etiologies.IRIS can also be seen in other immunocompromised conditions, such as:Solid organ transplant recipients Postpartum period – 3 to 6 weeks after giving birthNeutropenic patients – with an absolute neutrophil count of less than 500Patients on Tumor Necrosis Factor Antagonists (TNF antagonists)- are used to treat chronic conditions such as ulcerative colitis, Crohn's disease, or sarcoidosis.In summary, Immune Reconstitution Inflammatory Syndrome (IRIS) is a hyper-inflammatory state seen after initiating ART in HIV patients whose improved immune system responds to previously acquired opportunistic infection, whether treated or not.The treatment is directed to the unmasked specific opportunistic infection or support therapy if no active infection is found.____________________________Conclusion: Now we conclude episode number 121, “Immune Reconstitution Inflammatory Syndrome (IRIS).” This syndrome presents in about 30% of HIV patients when they start ART. A stronger immune system means a stronger immune reaction. So, keep in mind this diagnosis when your HIV patients get sicker when they are supposed to get better after starting ART. This week we thank Hector Arreaza, Abeda Farhati, and Katherine Schlaerth. Audio edition by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________Links:“CD4 Lymphocyte Count: MedlinePlus Medical Test.” Medlineplus.gov, accessed on November 4, 2022.https://medlineplus.gov/lab-tests/cd4-lymphocyte-count/#:~:text=A%20CD4%20count%20is%20mostly,have%20trouble%20fighting%20off%20infections.Sun HY, Singh N. Immune reconstitution inflammatory syndrome in non-HIV immunocompromised patients. Curr Opin Infect Dis. 2009 Aug;22(4):394-402. doi: 10.1097/QCO.0b013e32832d7aff. PMID: 19483618. https://pubmed.ncbi.nlm.nih.gov/19483618/Thapa, Sushma, and Utsav Shrestha. “Immune Reconstitution Inflammatory Syndrome.” PubMed, StatPearls Publishing, 2022, www.ncbi.nlm.nih.gov/books/NBK567803/.Wolfe, Cameron. Immune reconstitution inflammatory syndrome, UpToDate. ww.uptodate.com, https://www.uptodate.com/contents/immune-reconstitution-inflammatory-syndrome. Accessed November 14, 2022.Royalty-free music used for this episode: “Keeping Watch,” New Age Landscapes. Downloaded on October 13, 2022, from https://www.videvo.net/royalty-free-music-albums/new-age-landscapes/. 

I know, it's only November, but it's always a great time to have something to look forward to! In this episode I share the science of anticipation, and how looking forward helps us feel better. Sponsor: Visit betterhelp.com/livefreecreative and use LIVEFREE for 50% off your first month. Find full show notes at livefreecreative.co/podcast Follow Miranda on Instagram @livefreemiranda Get one-on-one coaching with Miranda at Patreon.com/livefreecreative Buy More Than Enough on Amazon Reference: Luo Y, Chen X, Qi S, You X, Huang X. Well-being and Anticipation for Future Positive Events: Evidences from an fMRI Study. Front Psychol. 2018 Jan 9;8:2199. doi: 10.3389/fpsyg.2017.02199. PMID: 29375415; PMCID: PMC5767250. Learn more about your ad choices. Visit megaphone.fm/adchoices

Scientific Sense ® by Gill Eapen: Prof Trey Ideker is Professor of Medicine, Bioengineering and Computer Science at the University of California, San Diego. He directs the National Resource for Network Biology, and the Cancer Cell Map and Psychiatric Cell Map Initiatives. A multi-scale map of cell structure fusing protein images and interactions. Nature. 2021 Nov 24. doi: 10.1038/s41586-021-04115 “We Might Not Know Half of What's in Our Cells, New AI Technique Reveals Interpretation of cancer mutations using a multiscale map of protein systems. Science. 2021 A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity. A protein interaction landscape of breast cancer. Science. 2021 Oct;374(6563):eabf3066 “Studies Delve Deep into the Protein Machinery of Cancer Cells.” NCI (4 Nov 2021) “From COVID to cancer, gene-mapping tool could ‘revolutionize' treatment“. SF Chronicle (2 Oc “Moonshot Project Aims to Understand and Beat Cancer Using Protein Maps“. Singularity Hub (5 Oct 2021) “Looking Beyond DNA to See Cancer with New Clarity,” Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells. Cancer Cell (2020), https://doi.org/10.1016/j.ccell.2020.09.014. PMID: 33096023. [PDF] [PubMed] Related Press: UCSD Health, AZoLifeSciences, Med India, Health IT Analytics and ScienceDaily. Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome. Cell Systems. 2020 Aug 26;11(2):176-185.e6. doi: 10.1016/j.cels.2020.06.006. Epub 2020 Jul 2. PMID: 32619550 [PDF] [PubMed] *Cover Article Related Press: Here's a better way to convert dog years to human years, scientists say. Science Magazine (15 Nov 2019). See also: Scientific American, BBC, NPR, Washington Post, Discover Magazine, Smithsonian, New York Post, (and more) Identifying Epistasis in Cancer Genomes: A Delicate Affair. Cell. 2019 May 30;177(6):1375-1383. doi: 10.1016/j.cell.2019.05.005. Review. PMID: 31150618 [PDF] [PubMed] Using deep learning to model the hierarchical structure and function of a cell.* Nat Methods. 2018 Mar 5. doi: 10.1038/nmeth.4627. PMID: 29505029 [PDF] [PubMed] [Cover Art] *Cover article Please subscribe to this channel: https://www.youtube.com/c/ScientificSense?sub_confirmation=1 --- Send in a voice message: https://anchor.fm/scientificsense/message Support this podcast: https://anchor.fm/scientificsense/support

Losing Weight With AppsCan a phone app help you lose weight? How about with your cholesterol, blood pressure, or waist size?Perhaps you've heard the latest Noom ads, where they boast forty publications showing that their app will help you lose weight.Apple is coming out with more ways to have their new watch track your heart rate and steps, with apps even looking at your yoga workout and eventually telling your blood glucose.Episode Sponsor: Modifyhealth.com What the Studies ShowA recent meta-analysis of randomized controlled trials showed that the average weight loss in the first three months was slightly below five pounds (2.18 kg).Unfortunately, the weight loss didn't last. Nine months later, they had regained a pound and a half for a total loss of 3.5 pounds (1.63 kg).Blood Pressure, Cholesterol, and CaloriesThere was a slight improvement in blood pressure at three months. But cholesterol and total energy intake, as well as waist circumference and blood glucose, remained the same.The Proliferation of AppsThere are over 500,000 applications on Android and Apple phones to track various health data points. In addition, there are other devices just measuring fitness. The theory of measuring fitness behaviors with calorie tracking to provide feedback to improve health is appealing.Many Apps With Poor QualityMany apps had a lack of behavioral coaching and poor quality of scientific information. Tracking over a three-day period found that the accuracy of energy intake among apps was only fair in terms of total calories and amounts of macro- and micronutrients.What About NoomNoom is one of the more popular paid apps. They boast over 40 peer-reviewed articles. A quick glance at the articles showed some surprising flaws:One article compared Noom in pancreatic cancer patients to a control group who received no coaching.Another article used Noom data for their references.Article after article that Noom sites are little more than using Noom's data without dropout rates. References:Chen J, Cade JE, Allman-Farinelli M. The Most Popular Smartphone Apps for Weight Loss: A Quality Assessment. JMIR Mhealth Uhealth. 2015 Dec 16;3(4):e104. doi: 10.2196/mhealth.4334. PMID: 26678569; PMCID: PMC4704947.Chew HSJ, Koh WL, Ng JSHY, Tan KK. Sustainability of Weight Loss Through Smartphone Apps: Systematic Review and Meta-analysis on Anthropometric, Metabolic, and Dietary Outcomes. J Med Internet Res. 2022 Sep 21;24(9):e40141. doi: 10.2196/40141. PMID: 36129739; PMCID: PMC9536524.Keum J, Chung M, Kim Y, Ko H, Sung M, Jo J, Park J, Bang S, Park S, Song S, Lee HUsefulness of Smartphone Apps for Improving Nutritional Status of Pancreatic Cancer Patients: Randomized Controlled Trial JMIR Mhealth Uhealth 2021;9(8):e21088 URL: https://mhealth.jmir.org/2021/8/e21088 DOI: 10.2196/21088Pohl, M. "325,000 mobile health apps available in 2017—Android now the leading mHealth platform. Research 2 Guidance." (2017).

Zoe Russell discusses ankle sprain assessment and treatment, and how to return your patients to sport. You'll discover how to help your ankle sprain patients fully recover as quickly as possible, and avoid long term issues, such as chronic ankle instability, osteoarthritis or other lower limb injuries.  Zoe is a Specialist Sports Physiotherapist (FACP), APA Titled Musculoskeletal and Sports Physio, as well as a Clinical Edge Senior Educator and Presenter, and in this Physio Edge podcast hosted by David Pope, we discuss the latest evidence and practical strategies for ankle sprains, including:    Assessment  Common issues therapists face when rehabilitating ankle sprain patients.  Questions you need to ask your ankle sprain patients.  How a previous history of ankle sprains impacts your assessment & treatment. Why patients with inversion injuries may have medial ankle pain. How to avoid stirring up patients pain during your assessment.   Diagnosis Common mechanisms of injury, and how this guides your diagnosis.  Structures that are likely to be injured with different ankle injuries.   Treatment  10 key elements to include in your assessment & treatment. How to help reduce swelling quickly after an ankle sprain, and why this is important. Immediate sideline management for ankle sprains at sporting events. Whether manual therapy has a role in acute ankle injuries or persistent ankle pain and swelling.  How to explain ankle sprains, recovery & rehab to your patient. What you're looking to achieve with your early rehab.  How to set rehab targets or goals with your patients. The role of taping in ankle rehab. Taping compared to bracing. Whether long term taping or bracing is a useful long term injury prevention strategy.  The latest surgical procedures for patients with chronic ankle instability (CAI).   Links Zoe Russell David Pope on Twitter Improve your musculoskeletal and sports injury assessment & treatment results with a free trial Clinical Edge membership Explain acute and persistent pain to your patients, without giving them the message “It's all in your head” with the Making sense of pain training module Comprehensive low back pain assessment & treatment training module David Pope at Clinical Edge References CLICK HERE to download the article associated with this podcast Bestwick-Stevenson, T., Wyatt, L. A., Palmer, D., Ching, A., Kerslake, R., Coffey, F., Batt, M. E., & Scammell, B. E. (2021). Incidence and risk factors for poor ankle functional recovery, and the development and progression of posttraumatic ankle osteoarthritis after significant ankle ligament injury (SALI): the SALI cohort study protocol. BMC musculoskeletal disorders, 22(1), 362. https://doi.org/10.1186/s12891-021-04230-8 Delco ML, Kennedy JG, Bonassar LJ, Fortier LA. Post-traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches. J Orthop Res. 2017 Mar;35(3):440-453. doi: 10.1002/jor.23462. Epub 2016 Nov 8. PMID: 27764893; PMCID: PMC5467729. Herzog MM, Kerr ZY, Marshall SW, Wikstrom EA. Epidemiology of Ankle Sprains and Chronic Ankle Instability. J Athl Train. 2019 Jun;54(6):603-610. doi: 10.4085/1062-6050-447-17. Epub 2019 May 28. PMID: 31135209; PMCID: PMC6602402. van Ochten, J. M., de Vries, A. D., van Putte, N., Oei, E., Bindels, P., Bierma-Zeinstra, S., & van Middelkoop, M. (2017). Association between Patient History and Physical Examination and Osteoarthritis after Ankle Sprain. International journal of sports medicine, 38(9), 717–724. https://doi.org/10.1055/s-0043-109554     Chapters: 03:47 - Untreated ankle sprains 05:27 - Latest evidence 07:04 - Subjective questions 09:45 - Common mechanisms of injury 11:47 - Plantarflexion/inversion injury with medial ankle pain 15:22 - Dorsiflexion eversion injuries 15:54 - Swelling 21:11 - Objective tests 26:32 - Irritability 26:47 - Figure of 8 taping technique 28:56 - Inferior and superior tib-fib joint assessment 32:14 - Treatment 42:41 - Change of direction 43:17 - Tape or brace? 50:06 - Mobilise or immobilise?

Dr. Kimberly Blumenthal (@KimberlyBlumen1), Dr. Meghan Jeffres (@PharmerMeg), and Dr. Eric Macy (@EricMacyMD) join Dr. Julie Ann Justo (@julie_justo) to summarize the history of cephalosporin avoidance in penicillin allergies, evidence-based pros and cons of giving cephalosporins in penicillin allergy, how to leverage technology to improve treatment of patients with penicillin allergies, and much more! Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/ References Macy E. Why Was There Ever a Warning Not to Use Cephalosporins in the Setting of a Penicillin "Allergy"? J Allergy Clin Immunol Pract. 2021 Nov;9(11):3929-3933. doi: 10.1016/j.jaip.2021.06.059. PMID: 34303019. Liang EH, et al. Adverse Reactions Associated with Penicillins, Carbapenems, Monobactams, and Clindamycin: A Retrospective Population-based Study. J Allergy Clin Immunol Pract. 2020 Apr;8(4):1302-1313.e2. doi: 10.1016/j.jaip.2019.11.035. PMID: 31821919. Macy E, Contreras R. Adverse reactions associated with oral and parenteral use of cephalosporins: A retrospective population-based analysis. J Allergy Clin Immunol. 2015 Mar;135(3):745-52.e5. doi: 10.1016/j.jaci.2014.07.062. PMID: 25262461. Macy E, et al. Population-Based Incidence of New Ampicillin, Cephalexin, Cefaclor, and Sulfonamide Antibiotic "Allergies" in Exposed Individuals with and without Preexisting Ampicillin, Cephalexin, or Cefaclor "Allergies". J Allergy Clin Immunol Pract. 2022 Feb;10(2):550-555. doi: 10.1016/j.jaip.2021.10.043. PMID: 34757066. Picard M, et al. Cross-Reactivity to Cephalosporins and Carbapenems in Penicillin-Allergic Patients: Two Systematic Reviews and Meta-Analyses. J Allergy Clin Immunol Pract. 2019 Nov-Dec;7(8):2722-2738.e5. doi: 10.1016/j.jaip.2019.05.038. PMID: 31170539. Romano A, et al. Cross-reactivity and tolerability of aztreonam and cephalosporins in subjects with a T cell-mediated hypersensitivity to penicillins. J Allergy Clin Immunol. 2016 Jul;138(1):179-186. doi: 10.1016/j.jaci.2016.01.025. PMID: 27016799. Romano A, et al. Cross-Reactivity and Tolerability of Cephalosporins in Patients with IgE-Mediated Hypersensitivity to Penicillins. J Allergy Clin Immunol Pract. 2018 Sep-Oct;6(5):1662-1672. doi: 10.1016/j.jaip.2018.01.020. PMID: 29408440. Blumenthal KG, et al. The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. Clin Infect Dis. 2018 Jan 18;66(3):329-336. doi: 10.1093/cid/cix794. PMID: 29361015. Blumenthal KG, et al. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018 Jun 27;361:k2400. doi: 10.1136/bmj.k2400. PMID: 29950489. Blumenthal KG, et al. Recorded Penicillin Allergy and Risk of Mortality: a Population-Based Matched Cohort Study. J Gen Intern Med. 2019 Sep;34(9):1685-1687. doi: 10.1007/s11606-019-04991-y. PMID: 31011962. Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin "allergy" in hospitalized patients: A cohort study. J Allergy Clin Immunol. 2014 Mar;133(3):790-6. doi: 10.1016/j.jaci.2013.09.021. PMID: 24188976. AAAI. Choosing Wisely. 2014 Mar 3. https://www.choosingwisely.org/clinician-lists/american-academy-allergy-asthma-immunlogy-non-beta-lactam-antibiotics-penicillin-allergy/ Jeffres MN, et al. Systematic review of professional liability when prescribing β-lactams for patients with a known penicillin allergy. Ann Allergy Asthma Immunol. 2018 Nov;121(5):530-536. doi: 10.1016/j.anai.2018.03.010. PMID: 29551402. Macy E, et al. Association Between Removal of a Warning Against Cephalosporin Use in Patients With Penicillin Allergy and Antibiotic Prescribing. JAMA Netw Open. 2021 Apr 1;4(4):e218367. doi: 10.1001/jamanetworkopen.2021.8367. PMID: 33914051. Blumenthal KG, et al. Addressing Inpatient Beta-Lactam Allergies: A Multihospital Implementation. J Allergy Clin Immunol Pract. 2017 May-Jun;5(3):616-625.e7. doi: 10.1016/j.jaip.2017.02.019. PMID: 28483315. Jeffres M. Penicillin and/or Beta-Lactam Allergy Tip Sheet & Cross-reactivity Table. https://drive.google.com/file/d/1cokYXnSDlO3vk8ke1LaalPz4iavuNSV8/view?usp=share_link Khan DA, et al. Drug allergy: A 2022 practice parameter update. J Allergy Clin Immunol. 2022 Sep 17:S0091-6749(22)01186-1. doi: 10.1016/j.jaci.2022.08.028. Epub ahead of print. PMID: 36122788. Guyer AC, et al. Allergy Electronic Health Record Documentation: A 2022 Work Group Report of the AAAAI Adverse Reactions to Drugs, Biologicals, and Latex Committee. J Allergy Clin Immunol Pract. 2022 Nov;10(11):2854-2867. doi: 10.1016/j.jaip.2022.08.020. PMID: 36151034. Iammatteo M, et al. Safety and Outcomes of Oral Graded Challenges to Amoxicillin without Prior Skin Testing. J Allergy Clin Immunol Pract. 2019 Jan;7(1):236-243. doi: 10.1016/j.jaip.2018.05.008. PMID: 29802906. Bavbek S, et al. Determinants of nocebo effect during oral drug provocation tests. Allergol Immunopathol (Madr). 2015 Jul-Aug;43(4):339-45. doi: 10.1016/j.aller.2014.04.008. PMID: 25088674. DePestel DD, et al. Cephalosporin use in treatment of patients with penicillin allergies. J Am Pharm Assoc (2003). 2008 Jul-Aug;48(4):530-40. doi: 10.1331/JAPhA.2008.07006. PMID: 18653431. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints. Check out our podcast host, Pinecast. Start your own podcast for free with no credit card required. If you decide to upgrade, use coupon code r-7e7a98 for 40% off for 4 months, and support Breakpoints.

In this cross-specialty episode of BackTable OBGYN, Dr. Amy Park chats with Dr. Jose Silva, a board certified urologist and co-host of BackTable Urology, about the workup, counseling, and management of urinary incontinence and pelvic organ prolapse. --- SHOW NOTES The co-hosts begin by briefly discussing the workup for pelvic organ prolapse (POP). Dr. Park identifies common symptoms of prolapse and special exams (e.g. Pelvic Organ Prolapse Quantification System or POP-Q and urodynamics) that may be utilized for initial evaluation. She then explains the clinical indications for treatment of isolated POP, in addition to POP with concomitant urinary incontinence. Drs. Park and Silva then transitioned to cover the management of urinary incontinence. The two co-hosts reveal the benefits of pelvic floor physical therapy and other conservative management options, such as core-centric exercises and weight loss. In length, they elaborate on the benefits and takeaways of using sling procedures versus urethral bulking agents (e.g. Bulkamid). When discussing these topics, the co-hosts bring to light the possible differences in approach between Urogynecologists and Urologists. In regard to urethral bulking agents for treatment of urinary incontinence, Drs. Park and Silva highlight the potential role for stem cell injections. In addition, Dr. Park provides a tip to maximize patient comfort during in-office periurethral injections for urethral bulking. When focusing on sling procedures, Dr. Park highlights her preferred approach and encourages listeners to become proficient in the approach of their choosing. Lastly, they describe their approaches to treatment of stress urinary incontinence. In their discussion, Drs. Park and Silva consider factors such as patient age, desire for future fertility, and pregnancy. When wrapping up the episode, Dr. Park emphasizes the importance of patient counseling when it comes to management of these conditions, as well as practicing shared decision making to determine the best next steps for her patients. --- RESOURCES Nager CW, et al. Design of the Value of Urodynamic Evaluation (ValUE) trial: A non-inferiority randomized trial of preoperative urodynamic investigations. Contemp Clin Trials. 2009 Nov;30(6):531-9. doi: 10.1016/j.cct.2009.07.001. Epub 2009 Jul 25. PMID: 19635587; PMCID: PMC3057197. Erin A. Brennand, Shunaha Kim-Fine. A randomized clinical trial of how to best position retropubic slings for stress urinary incontinence: Development of a study protocol for the mid-urethral sling tensioning (MUST) trial, Contemporary Clinical Trials Communications, Volume 3, 2016, Pages 60-64, ISSN 2451-8654, https://doi.org/10.1016/j.conctc.2016.04.004. M. Abdel-Fattah, D. Cooper, T. Davidson, M. Kilonzo, M. Hossain, D. Boyers, et al. Single-Incision Mini-Slings for Stress Urinary Incontinence in Women New England Journal of Medicine 2022 Vol. 386 Issue 13 Pages 1230-1243. DOI: 10.1056/NEJMoa2111815 https://doi.org/10.1056/NEJMoa2111815. Persu C, Chapple CR, Cauni V, Gutue S, Geavlete P. Pelvic Organ Prolapse Quantification System (POP-Q) - a new era in pelvic prolapse staging. J Med Life. 2011 Jan-Mar;4(1):75-81. Epub 2011 Feb 25. PMID: 21505577; PMCID: PMC3056425.

In this episode of the Epigenetics Podcast, we caught up with Elena Gomez-Diaz from the Institute of Parasitology and Biomedicine López-Neyra at the Spanish National Research Council. She share with us her work on the Epigenetics in Human Malaria Parasites. Elena Gómez-Díaz and her team are focusing on understanding how epigenetic processes are implicated in host-parasite interactions by regulating gene expression in the model of malaria. The team has started to investigate and uncover layers of chromatin regulation that control developmental transitions in Plasmodium falciparum, especially in the parts of the life cycle that take place in the mosquito. Furthermore, the lab has investigated epigenetic changes that are present in malaria-infected Anopheles mosquitos, this led to the identification of cis-regulatory elements and enhancer-promoter networks in response to infection.   References Gómez-Díaz E, Rivero A, Chandre F, Corces VG. Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae. Front Genet. 2014 Aug 15;5:277. doi: 10.3389/fgene.2014.00277. PMID: 25177345; PMCID: PMC4133732. Gómez-Díaz, E., Yerbanga, R., Lefèvre, T. et al. Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae. Sci Rep 7, 40655 (2017). https://doi.org/10.1038/srep40655 José Luis Ruiz, Juan J Tena, Cristina Bancells, Alfred Cortés, José Luis Gómez-Skarmeta, Elena Gómez-Díaz, Characterization of the accessible genome in the human malaria parasite. Plasmodium falciparum, Nucleic Acids Research, Volume 46, Issue 18, 12 October 2018, Pages 9414–9431, https://doi.org/10.1093/nar/gky643 Women in Malaria 2021: A Conference Premier. (2021). Trends in Parasitology, 37(7), 573–580. https://doi.org/10.1016/j.pt.2021.04.001 Twitter Account: https://twitter.com/womeninmalaria   Related Episodes Multiple challenges of CUT&Tag (Cassidee McDonough, Kyle Tanguay) ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)   Contact Epigenetics Podcast on Twitter Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Active Motif on Twitter Active Motif on LinkedIn Email: podcast@activemotif.com

In this podcast we discuss the prevalence of bacteremia and even more interestingly the prevalence of meningitis in febrile infants

Tim Dillon, John Deas, Paul Deemer, D Madness, Michael A. Gonzales, William Montgomery, Hans Kim, David Lucas, Jules Durel, Joe White, Kristie Nova, Yoni, Tony Hinchcliffe, Brian Redban – 10/31/2022–THIS EPISODE IS SPONSORED BY:BOX OF AWESOME! – From style and grooming goods, tobarware, cooking tools, and outdoor gear, Box of Awesome hascollections for every part of your life. – Get 20% off your first monthly box when you sign upat BOXOFAWESOME.COM and enter the code “KILLTONY” at checkout.—Kimpton Hotel Van Zandt – Save on Sunday and Monday nights when you stay at Hotel Van Zandt using this link: CLICK HERE!

Welcome to Teeth & Titanium Episode 26 - Dr. Brian Farrell This episode features: Current events - Recorded at the new T&T studio - Where are the Caesars? - A world class bet - University of Toronto Alumni Event recap Guest - Orthognathics and life lessons with Dr. Brian Farrell - Wendell learns to stay in his lane - Oscar gets an upgrade Resident Reminder - How to prepare and choose a fellowship Journal Club - Comparable Skeletal and Dental Movements Achieved Using Conventional and Surgery-First Techniques in Class III Patients Recommendations - The beautiful game - unique and lesser-known sports stories Be sure to subscribe so you never miss an episode! Apple / Spotify / Google / Online links Thanks to the CAOMS for their continued support of this podcast. https://www.caoms.com If you would like to contact us, be a guest, or would like to submit a topic for Resident Reminder or Journal club, please email us at: teethandtitaniumOMFS@gmail.com Hosted by Dr. Wendall Mascarenhas and Dr. Oscar Dalmao Produced by Dr. Brad W. Ray Articles cited in this episode: Florentine C, Kimberly A, Mehta S, Kuo CL, Uribe F, Lottinger C. Comparable Skeletal and Dental Movements Achieved Using Conventional and Surgery-First Techniques in Class III Patients. J Oral Maxillofac Surg. 2022 Nov;80(11):1747-1756. doi: 10.1016/j.joms.2022.08.003. Epub 2022 Aug 10. PMID: 36076358.

Are you a transracial adoptive or foster parent? Have you wondered how you can help your child form a healthy racial identity. Does racial identity formation change depending on the race of the child? Today we talk about all this and more with Dr. Gina Miranda Samuels, a professor at the University of Chicago and Director of the Center for the Study of Race, Politics and Culture. She is a transracial adoptee and co-author of the book Multiracial Cultural Attunement.In this episode, we cover:How do children in the US come to understand race at different ages and developmental stages?How early do children develop a racial bias? How early do children associate certain characteristics to race and show a preference towards a person of a certain race? How does transracial adoption or fostering or kinship care impact a child's understanding of race?How does transracial or transcultural adoption or fostering or kinship care impact children? Racial identity formation: How does being adopted transracially impact the adoptee's racial identity formation?Coping with racismIn your research and in your experience, do you see a difference in the experience of race is perceived by both transracial adoptees or adoptive or foster parents depending on the race of the child? Asian, Latinx, Black, Bi-racial?Why is taking the colorblind approach to parenting not helpful? “It's About More Than Hair”Transracial parenting requires the family to be fluent in “race talk” – socialization is not a conversation, it is a daily, incremental, and developmental family process.As our kids age, what is it like for our tweens, teens, and young adults to have parents of a different race?How does transracial adoption or fostering impact siblings in the family who are the same race as the parents?How does transracial adoption or fostering affect extended family members, such as grandparents and aunts and uncles?Practical tips for parents raising a child of a different race or ethnicity.Additional Resources:Diverse Book FinderThe Brown Bookshelf – highlights Black voices writing for young readers.The Conscious Kid Multiracial Cultural Attunement by Gina Miranda Samuels and Kelly Faye Jackson, 2019Tips for parenting your transracially adopted child by Dr. Gina Samuels EmbraceRace was founded to create the community and gather the resources they needed (need!) to meet the challenges faced by those raising children in a world where race matters.Dr. Erin Winkler, Children Are Not Colorblind: How Young Children Learn RaceHamilton ER, Samek DR, Keyes M, McGue MK, Iacono WG. Identity Development in a Transracial Environment: Racial/Ethnic Minority Adoptees in Minnesota. Adopt Q. 2015;18(3):217-233. doi: 10.1080/10926755.2015.1013593. PMID: 26300622; PMCID: PMC4540225.  This podcast is produced  by www.CreatingaFamily.org. We are a national non-profit with the mission to strengthen and inspire adoptive, foster & kinship parents and the profesSupport the showDo you want more expert-based information? Check out our free resources at CreatingaFamily.org.

Tired of a flaky scalp or the sticky way topical Minoxidil leaves your hair and scalp feeling? Learn why low-dose oral Minoxidil might be your best option! PMID: 24773771 DOI: 10.1111/dth.12130Epub ahead of print. PMID: 32614119https://donovanmedical.com/hair-blog/topical-oral-minoxidil#sthash.0kQBVE1e.dpufConnect with us:Kimberly Vaughn, WTS, ITS, CNC, MBA: www.hpihairpartners.comConsultations with Kimberly: https://hpihairpartners.com/consultation-requestNataliia Sanzo, RD, LDN, CHWC www.allpurposenutrition.comIG: all.purpose.nutrition https://www.instagram.com/all.purpose.nutrition/Questions/Comments? We look forward to your emails!THLC@hpihairpartners.com

Did you know that a mild respiratory infection could be the culprit of an adverse respiratory event during a patient undergoing anesthesia? Dr. Pedro Solorzano and Dr. Ana Mavarez join Krishna Shah to discuss the evaluation and management of upper respiratory infections for patients undergoing anesthetic care. Specifically, they will:   Recall key aspects of the preoperative assessment performed by the pediatric anesthesiologist prior to perform an anesthetic.   Understand why an upper respiratory infection (URI) affects the pediatric anesthesiologist's decision to proceed or postpone a surgery or procedure requiring anesthesia or sedation.   Identify the severity of the URI symptoms that would increase the likelihood of perioperative respiratory adverse events (PRAE).   Understand the anesthetic management of a patient with an URI to minimize the risk of PRAE requiring emergent anesthesia and the timing to postpone it if the surgery is elective.  Initiate interventions to optimize the pediatric patient's respiratory status with URI prior to receiving anesthesia.   FREE CME Credit (requires free sign-up): Link coming soon! References:  Davis, Peter J. and Cladis, Franklyn, "Smith's Anesthesia for Infants and Children. 9th ed. (2017). Chapter 45. Respiratory disorders. Page 1127-1128. Von Ungern-Sternberg BS, Boda K, Chambers NA, Rebmann C, Johnson C, Sly PD, Habre W. Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort study. Lancet. 2010 Sep 4;376(9743):773-83. doi: 10.1016/S0140-6736(10)61193-2. PMID: 20816545. Regli A, Becke K, von Ungern-Sternberg BS. An update on the perioperative management of children with upper respiratory tract infections. Curr Opin Anaesthesiol. 2017 Jun;30(3):362-367. doi: 10.1097/ACO.0000000000000460. PMID: 28291127. Cote C, Lerman J amd Anderson B, A Practice of Anesthesia for Infants and Children. 6th ed. (2019). Chapter 13. Essentials of pulmonology. Page 285-286. Houck, P. Anesthesia for the child with a recent upper respiratory infection. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA

After listening to this episode on Tetralogy of Fallot with Pulmonary Stenosis, learners should be able to:Recognize the relevant preoperative anatomy that influences operative plan and postoperative care in the cardiac intensive care unit (CICU).Recall the goals and general steps of operative repair.Recognize the key information provided in surgical and anesthesia handover that will affect postoperative management.Recognize the common and important postoperative complications and develop an approach to their management.Develop a mental framework of the expected postoperative CICU course with a focus on common or important barriers to ICU discharge.About our guest:Dr. Laura Ortmann is an Associate Professor in the Department of Pediatrics at the University of Nebraska College of Medicine. She serves as the Medical Director of the Cardiovascular Intensive Care Unit at Children's Hospital and Medical Center in Omaha, Nebraska. She a CPR researcher and a great medical educator. She is a host on the Healing Hearts Podcast featuring her ongoing cardiac lesions series and produces MedEd videos on YouTube at DrOrtmannCICU. References:Ortmann LA, Keshary M, Bisselou KS, Kutty S, Affolter JT. Association Between Postoperative Dexmedetomidine Use and Arrhythmias in Infants After Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2019 Jul;10(4):440-445. doi: 10.1177/2150135119842873. PMID: 31307294.How to support PedsCrit:Please rate and review on Spotify or Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.Support the show

In this episode, Marc and Mo discuss several recent JBJS and OE articles that caught their eye. The first part of the discussion focuses on selected highlights from the recent meeting of the OTA (specifically, anti-sepsis approaches in open fracture management), and the second part focuses on the recently published JBJS Supplement on the use of large databases in orthopaedic research. Links: OTA 2022: Key Findings from This Year’s RCTs and Meta-Analyses. OE Insights. 2022. https://myorthoevidence.com/Insight/Show/147 JBJS Supplement on Large Database and Registry Research in Joint Arthroplasty and Orthopaedics. https://jbjs.org/collection.php?id=22 Khosravi B, Rouzrokh P, Erickson BJ. Getting More Out of Large Databases and EHRs with Natural Language Processing and Artificial Intelligence: The Future Is Here. J Bone Joint Surg Am. 2022 Oct 19;104(Suppl 3):51-55. doi: 10.2106/JBJS.22.00567. Epub 2022 Oct 19. PMID: 36260045. https://bit.ly/3suFxqK Swiontkowski MF, Callaghan JJ, Lewallen DG, Berry DJ. Large Database and Registry Research in Joint Arthroplasty and Orthopaedics. J Bone Joint Surg Am. 2022 Oct 19;104(20):1775-1777. doi: 10.2106/JBJS.22.00405. Epub 2022 Oct 19. PMID: 36260046. https://bit.ly/3TFAQ9o Subspecialties: Ethics Hip Infection Knee Orthopaedic Essentials Trauma

Should preadolescents and adolescents strength train? Is there an appropriate way to weight lift when in an athletic season? Should parents be just as involved in school athletics as they are in academics? In this episode, Jay and Jesse discuss recommendations provided from different organizations across the globe and give their expert opinions on the matter. Giveaway information: Click the link below and leave a review on your performed platform and then head over to facebook.com/mannafit/ and type done on one of the giveaway post in order to be entered in the giveaway. Giveaway ends Nov. 21 when the episode drops.https://lovethepodcast.com/waHgNwReferences:Malina RM. Weight training in youth-growth, maturation, and safety: an evidence-based review. Clin J Sport Med. 2006 Nov;16(6):478-87. doi: 10.1097/01.jsm.0000248843.31874.be. PMID: 17119361.https://www.mayoclinic.org/healthy-lifestyle/tween-and-teen-health/in-depth/strength-training/art-20047758https://www.bodybuilding.com/content/weight-lifting-for-children-and-teens.htmlhttps://www.researchgate.net/publication/267395058_STRENGTH_TRAINING_FOR_THE_YOUNG_ATHLETE Hosted on Acast. See acast.com/privacy for more information.

In this podcast, Joe Tonna tells us how to approach hypothermia with ECPR patients.  He also goes through his paper RESCUE-IHCA giving us an immediate way to prognosticate in patients to use of ECMO or not.   Hypothermia - Resuscitation Nakashima T, Ogata S, Noguchi T, Nishimura K, Hsu CH, Sefa N, Haas NL, Bĕlohlávek J, Pellegrino V, Tonna JE, Haft J, Neumar RW. Association of intentional cooling, achieved temperature and hypothermia duration with in-hospital mortality in patients treated with extracorporeal cardiopulmonary resuscitation: An analysis of the ELSO registry. Resuscitation. 2022 Aug;177:43-51. doi: 10.1016/j.resuscitation.2022.06.022. Epub 2022 Jul 3. PMID: 35788020. Hypothermia Meta-Analysis Duan J, Ma Q, Zhu C, Shi Y, Duan B. eCPR Combined With Therapeutic Hypothermia Could Improve Survival and Neurologic Outcomes for Patients With Cardiac Arrest: A Meta-Analysis. Front Cardiovasc Med. 2021 Aug 13;8:703567. doi: 10.3389/fcvm.2021.703567. PMID: 34485403; PMCID: PMC8414549. In Hospital Cardiac Arrest and ECPR Inclusion Tonna JE, Selzman CH, Girotra S, Presson AP, Thiagarajan RR, Becker LB, Zhang C, Rycus P, Keenan HT; American Heart Association Get With the Guidelines–Resuscitation Investigators. Resuscitation Using ECPR During In-Hospital Cardiac Arrest (RESCUE-IHCA) Mortality Prediction Score and External Validation. JACC Cardiovasc Interv. 2022 Feb 14;15(3):237-247. doi: 10.1016/j.jcin.2021.09.032. Epub 2022 Jan 12. PMID: 35033471; PMCID: PMC8837656.

Episode 118: Wernicke's Encephalopathy Dr. Malave explains the diagnosis and treatment of Wernicke's encephalopathy. Editing and comments by Hector Arreaza.  Written by Maria Fernanda Malave, edited by Hector Arreaza, MD.You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Definition.As a reminder for everyone, vitamin B1 and thiamine are the same substance with different names. Wernicke's encephalopathy (WE) is a neurological syndrome secondary to severe, short-term B1 deficiency. In the past, but less frequently nowadays, it was more commonly associated with alcohol use disorder. However, today we know that any condition that decreases dietary intake and increases thiamine use, or its elimination, puts patients at risk of developing this encephalopathy. Causes:Chronic alcoholism is the most important cause of WE. Around 70-80% of the causes are associated with chronic alcohol consumption. Non-alcoholic WE may be caused by Decreased intake: Some types of WE may be caused by a psychiatric illness that decreases the dietary intake of B1, such as anorexia nervosa, schizophrenia, or dementia. Arreaza: Also, prolonged fasting or starvation.Lack of absorption of B1: Other causes might be related to malabsorptive syndromes, bariatric surgeries, or hyperemesis gravidarumIncreased use of B1: Any disease that increases the use of B1 and, therefore, low levels of thiamine, such as cancer, thyrotoxicosis, and systemic illnesses like infections. High-carb diets are associated with high thiamine use. Also, patients who receive IV glucose w/o supplements are at risk of developing Wernicke's encephalopathy.Increased elimination of B1: Other causes are related to increased elimination of B1, such as dialysis.Immunodeficiencies: Immunodeficiency syndromes and transplantation also cause WE.Why is thiamine important?Thiamine is one of the main cofactors in three key enzymes for energy metabolism: alpha-ketoglutarate dehydrogenase, pyruvate dehydrogenase, and transketolase. If we go back to biochemistry in med school, we can remember these enzymes play a significant role in the Krebs cycle and pentose phosphate pathways. Thiamine uses Mg+2 as a cofactor, so a magnesium deficiency can mimic WE.Pathophysiology.B1 deficiency causes lactic acid accumulation due to anaerobic glycolysis, leading to neuronal cytotoxic edema and vasogenic edema with petechial hemorrhages. MRI of the brain shows symmetrical hyperintensities, most commonly in the thalamus, mammillary bodies, cerebellum, and the periaqueductal area surrounding the third and fourth ventricles. The diagnosis of WE is made clinically, even though the MRI is a useful complementary tool to the clinical diagnosis. Diagnosis.WE presentation has always been described as the classic triad of ophthalmoplegia (or nystagmus), encephalopathy (confusion or memory impairment), and gait ataxia. However, this presentation is present only in less than 20% of patients, and most of the patients present with a neurologic syndrome that includes 2 out of the classic triad plus nonspecific symptoms such as hallucinations, hypothermia, hypotension, indifference or inattentiveness, seizures, behavioral disturbances, and bilateral lower extremity weakness. In 1997, Caine et al. suggested that a diagnosis of WE can be made if 2 out of 4 of these criteria were present in a patient with ophthalmoplegia/nystagmus + ataxia + memory impairment or confusion and clinical evidence of malnutrition or from laboratory data. Thiamine levels can be normal in patients with WE, so thiamine level is not a requirement for diagnosis.Almost 80% of WE cases are diagnosed on autopsy, which means this disease goes undiagnosed most of the time. The diagnosis is clinical, and MRI can assist in cases that are uncertain. Treatment.Thiamine supplementation is inexpensive, accessible, and easy to administer, so if we have a patient with a suspicious neurologic syndrome that could be WE, B1 must be given as soon as possible. Treatment should not be delayed while waiting for MRI results, The treatment consists of IV thiamine 500mg TID for 2-3 days, followed by 250 IM or IV for additional 5 days, in combination with other B vitamins. Because GI absorption of thiamine is impaired in alcoholics and malnourished patients, oral administration is contraindicated during initial treatment for WE. Thiamine 100 mg PO should be continued after the completion of parenteral treatment and after discharge from the hospital until patients are no longer considered at risk. Magnesium and other vitamins are replaced as well, along with other nutritional deficits if present.B1 blood levels or erythrocyte transketolase activity (which is a way to evaluate thiamine deficiency) are measured before and after thiamine pyrophosphate supplementation. A low transketolase and a more than 25 percent stimulation are positive for thiamine deficiency. This test is often not readily available, especially at the ED. High-quality liquid chromatography can also measure serum thiamine or TPP level in serum or whole blood.For practical purposes, and given high undiagnosed rates and mortality, IV thiamine should be given to all patients with malnutrition admitted to the hospital or seen in clinic. __________________________Conclusion: Now we conclude episode number 117 “Wernicke's Encephalopathy.” Dr. Malave explained that a low thiamine level is not required for the diagnosis of Wernicke's encephalopathy. Start supplementation if you have a high suspicion of thiamine deficiency, especially before giving IV glucose to a malnourished patient. We were reminded that GI absorption of thiamine is impaired in patients with chronic alcohol use, so make sure you give thiamine IV or IM. This week we thank Hector Arreaza and Maria Fernanda Malave. Audio edition by Adrianne Silva.Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________Links:He Jingqi, Li Jinguang, Li Zhijun, Ren Honghong, Chen Xiaogang, Tang Jinsong. A Case Report of Wernicke's Encephalopathy Associated with Schizophrenia. Frontiers in Psychiatry. Vol 12. Year 2021. DOI=10.3389/fpsyt.2021.657649. https://www.frontiersin.org/articles/10.3389/fpsyt.2021.657649/fullOta, Y., Capizzano, A.A., Moritani, T. et al. Comprehensive review of Wernicke encephalopathy: pathophysiology, clinical symptoms and imaging findings. Jpn J Radiol 38, 809–820 (2020). https://doi.org/10.1007/s11604-020-00989-3.Yuen T So, MD, PhD, Wernicke encephalopathy, last updated: Feb 11, 2020, UpToDate. Retrieved October 25, 2022.https://www.uptodate.com/contents/wernicke-encephalopathy.Patel S, Topiwala K, Hudson L. Wernicke's Encephalopathy. Cureus. 2018 Aug 22;10(8):e3187. doi: 10.7759/cureus.3187. PMID: 30364782; PMCID: PMC6199146. https://pubmed.ncbi.nlm.nih.gov/30364782/Royalty-free music used for this episode: Simon Pettersson – good vibes_ Fashionista, downloaded on October 1, 2022, from https://www.videvo.net 

In this solo episode of the Female Athlete Nutrition podcast, I take a deep dive into all things carbohydrates. I explore why your body needs carbohydrates for basic health, as well as performance and recovery, and explain why carbs really are life! First, I differentiate between simple and complex carbohydrates, rather than good and bad carbs, and explain the importance of having both in your diet. I speak to the importance of fiber, while emphasizing the consequences of consuming too much, including poor digestion and energy: more fiber is definitely not always better! Next, I debunk some diet culture myths around low carb diets and dietary recommendations, before sharing why higher carbohydrate diets are beneficial for athletes. As my clients have found out, there is more to muscle recovery than protein: again, carbohydrates are key here! I share some client success stories and explain why refined, white carbohydrates may be better for you than whole, fiber-rich grains. I leave listeners with the advice to consider increasing their carbohydrate intake if they are serious about health and performance: despite what society says, carbohydrates really are your friend! Here is the study I mentioned about carbohydrates and iron: Hayashi N, Ishibashi A, Iwata A, Yatsutani H, Badenhorst C, Goto K. Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females. Physiol Rep. 2022 Jul;10(13):e15351. doi: 10.14814/phy2.15351. PMID: 35785528; PMCID: PMC9251860. Need help with your fueling? Want to get in touch with Lindsey? Interested in the Female Athlete System of Transformation?  Head to www.RiseUpNutritionRUN.com to learn more & book a call! THANK YOU TO OUR SPONSORS: Inside Tracker: www.insidetracker.com/riseup for 20% off the entire store for a limited time only! THIS PODCAST IS ALSO SUPPORTED BY: Practice Better Click the link below to view plans and get a 14-day free trial. Then use the code RISEUP20 for 20% off your first 4 months: https://practicebetter.grsm.io/runp  TOPIC TIMESTAMPS: 2:30 Sneak peak into upcoming solo episodes. 8:30 Influence of carbohydrates on hydration, iron levels, and nutrient absorption. 14:00 Carbohydrates for performance and recovery.  16:15 Diet culture and misinformation on carbs.  20:00 Carbohydrates by the numbers: unpacking “low carb diets” and dietary recommendations. 26:30 Types of carbohydrates: simple vs complex, not good vs bad.  33:00 Fiber and digestion. More fiber is not always better, and refined (white) grains may be better than whole (brown) grains. 40:30 Client success stories: how increasing refined carbohydrates and decreasing fiber led to improving health and performance, hormones and energy. 46:15 High carbohydrate diets for improving athletic performance and recovery. 50:30 Carbohydrates for crushing training and achieving performance breakthroughs. 

In this episode, our team provides a comprehensive review of the differential diagnosis for mediastinal masses, their workup, and biopsy considerations. Listen as we dive deeper into the perioperative planning and operative approach for resection of these masses with special considerations for patients with thymoma.  Learning Objectives: -Discuss the differential diagnosis of a mediastinal mass -Review the workup of a mediastinal mass -Outline indications for biopsy and describe the various approaches -Describe the operative techniques for thymectomy, pearls & potential pitfalls   Hosts:  Megan Lenihan MD, Kelly Daus MD, Peter White MD, and Brian Louie MD Referenced Material https://pubmed.ncbi.nlm.nih.gov/21847052/ Detterbeck FC, Nicholson AG, Kondo K, Van Schil P, Moran C. The Masaoka-Koga stage classification for thymic malignancies: clarification and definition of terms. J Thorac Oncol. 2011 Jul;6(7 Suppl 3):S1710-6. doi: 10.1097/JTO.0b013e31821e8cff. PMID: 21847052. https://pubmed.ncbi.nlm.nih.gov/33468329/ Ahmad U. The eighth edition TNM stage classification for thymic tumors: What do I need to know? J Thorac Cardiovasc Surg. 2021 Apr;161(4):1524-1529. doi: 10.1016/j.jtcvs.2020.10.131. Epub 2020 Nov 13. PMID: 33468329. https://pubmed.ncbi.nlm.nih.gov/34695605/ Marx A, et al. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? J Thorac Oncol. 2022 Feb;17(2):200-213. doi: 10.1016/j.jtho.2021.10.010. Epub 2021 Oct 22. PMID: 34695605. https://pubmed.ncbi.nlm.nih.gov/22882218/ Meriggioli MN, Sanders DB. Muscle autoantibodies in myasthenia gravis: beyond diagnosis? Expert Rev Clin Immunol. 2012 Jul;8(5):427-38. doi: 10.1586/eci.12.34. PMID: 22882218; PMCID: PMC3505488. https://pubmed.ncbi.nlm.nih.gov/34339670/ Raja SM, Guptill JT, McConnell A, Al-Khalidi HR, Hartwig MG, Klapper JA. Perioperative Outcomes of Thymectomy in Myasthenia Gravis: A Thoracic Surgery Database Analysis. Ann Thorac Surg. 2022 Mar;113(3):904-910. doi: 10.1016/j.athoracsur.2021.06.071. Epub 2021 Jul 30. PMID: 34339670. Ad referenced in episode: A team at the Brooke Army Medical Center is working to better define proficiency-based metrics for competency in commonly performed general surgery procedures. If you are a PGY4/5 general surgery resident or practicing surgeon who performs robotic assisted cholecystectomies or inguinal hernia repairs, reach out to the PI, Robert Laverty, MD, at rblaverty@gmail.com, for more information on how you could be compensated up to $400 for recording and submitting those videos. Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out other clinical challenge episodes here: https://behindtheknife.org/podcast-series/clinical-challenges/

Pour apprendre à créer rapidement et à moindre coût son podcast, c'est par ici : https://www.neurosapiens.fr/commentcreerunpodcast Comment devient-on droitier ou gaucher ? Pourquoi existe-t-il aussi peu de gauchers ? Pourquoi notre cerveau a besoin que nous soyons soit droitier soit gaucher ? Existe-t-il des différences entre le cerveau d'un droitier et le cerveau d'un gaucher ? Production, animation, réalisation et illustration : Anaïs Roux Instagram : https://www.instagram.com/neurosapiens.podcast/ neurosapiens.podcast@gmail.com Produit et distribué en association avec LACME Production. Musique  KEEP ON GOING Musique proposée par La Musique Libre Joakim Karud - Keep On Going : https://youtu.be/lOfg0jRqaA8 Joakim Karud : https://soundcloud.com/joakimkarud ONE NIGHT AWAY Musique de Patrick Patrikios Sources :  McManus, I. C., & Bryden, M. P. (1992). The genetics of handedness, cerebral dominance, and lateralization. In I. Rapin & S. J. Segalowitz (Eds.), Handbook of neuropsychology, Vol. 6, pp. 115–144). Elsevier Science. Hepper PG. The developmental origins of laterality: fetal handedness. Dev Psychobiol. 2013 Sep;55(6):588-95. doi: 10.1002/dev.21119. Epub 2013 Jun 13. PMID: 23765736. M. Papadatou-Pastou, et al.: The prevalence of left-handedness: Five meta-analyses of 200 studies totaling 2,396,170 individuals. PsyArXiv. 23, 10.31234/osf.io/5gjac, 2019. Cuellar-Partida, G., Tung, J.Y., Eriksson, N. et al. Genome-wide association study identifies 48 common genetic variants associated with handedness. Nat Hum Behav 5, 59–70 (2021). https://doi.org/10.1038/s41562-020-00956-y A. Wiberg et al., Handedness, language areas and neuropsychiatric diseases : insights from brain imaging and genetics, Brain, vol. 142, pp. 2938-2947, 2019. Sha, Zhiqiang & Pepe, Antonietta & Schijven, Dick & Carrion Castillo, Amaia & Roe, James & Westerhausen, René & Marc, Joliot & Fisher, Simon & Crivello, Fabrice & Francks, Clyde. (2021). Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals. Proceedings of the National Academy of Sciences.

In this episode, we will define Digital Health, its categories and examples, describe how pharmacists are involved in DH practice, opportunities and limitations and future of DH. We will also discuss what implications DH has for educators, educational institutions, student pharmacists, pharmacists, and practice of pharmacy in general. Key Concepts Digital Health is currently a broad umbrella category that uses mobile health, telehealth, web-based platforms, personalized medicine, and IT to provide scalable patient care. There are several focused areas within DH that would impact pharmacy practice by warranting pharmacist oversight or collaborative insights. There is positive data for pharmacist-led DH interventions using mobile apps and web-based tools, but the use of telehealth modality has mixed results. Pharmacists need to stay current in their knowledge and skills for utilizing DH tools in integrative and collaborative patient care. References Aungst TD, Franzese C, Kim Y. Digital health implications for clinical pharmacists services: A primer on the current landscape and future concerns. J Am Coll Clin Pharm. 2020;4(4):514-524. DOI: 10.1002/jac5.1382. https://accpjournals.onlinelibrary.wiley.com/doi/abs/10.1002/jac5.1382 American Association of Colleges of pharmacies. Digital Health Workshop - Resources. https://www.aacp.org/resource/digital-health-workshop-resources (Lists resources from Digital Therapeutics Alliance and Digital Medicine Society) Park T, Muzumdar J, Kim H. Digital Health Interventions by Clinical Pharmacists: A Systematic Review. Int J Environ Res Public Health. 2022 Jan 4;19(1):532. doi: 10.3390/ijerph19010532. PMID: 35010791; PMCID: PMC8744767.

Big Jay Oakerson, Luis J Gomez, Dave Smith, Kim Congdon, Ali Macofsky, Hans Kim, William Montgomery, Kristie Nova, Yoni, Tony Hinchcliffe, Brian Redban – 10/10/2022–THIS EPISODE IS SPONSORED BY:LIQUID-IV.COM – GET 25% OFF ANY ORDER WITH PROMO CODE: “TONY” AT: LIQUID-IV.COM—Kimpton Hotel Van Zandt – Save on Sunday and Monday nights when you stay at Hotel Van Zandt using this link: CLICK HERE!

Does your child prefer to play one sport over another? Do they have natural talent in a sport? Is sports specialization really as bad as they say? In today's episode, Jay and Jesse discuss your questions and provide a unique take on the subject.Giveaway information: Click the link below and leave a review on your performed platform and then head over to facebook.com/mannafit/ and type done on one of the giveaway post in order to be entered in the giveaway. Giveaway ends Nov. 21 when the episode drops.https://lovethepodcast.com/waHgNwReferences:Jayanthi N, Kleithermes S, Dugas L, Pasulka J, Iqbal S, LaBella C. Risk of Injuries Associated With Sport Specialization and Intense Training Patterns in Young Athletes: A Longitudinal Clinical Case-Control Study. Orthop J Sports Med. 2020 Jun 25;8(6):2325967120922764. doi: 10.1177/2325967120922764. PMID: 32637428; PMCID: PMC7318830.https://www.nata.org/blog/beth-sitzler/youth-sports-specialization-recommendationshttps://movestrongphysicaltherapy.com/new-blog/early-sport-specialization-cross-training-importancehttps://www.youtube.com/watch?v=zOmPAmv0u0Ehttps://www.sportskeeda.com/nfl/news-derek-carr-never-skipped-church-despite-grueling-football-travel-schedule-thanks-parents https://www.uhhospitals.org/Healthy-at-UH/articles/2021/06/beware-of-early-sports-specialization-for-young-athletes Hosted on Acast. See acast.com/privacy for more information.

“Thankful for Turkey: What we know about Turkey & Periodontitis” Fast Facts: Perio Edition   Thanksgiving is upon us, and we'd be remiss to celebrate Turkey and not talk about what we understand about Turkey and periodontitis. Today's, Fast Facts Perio edition looks at some of the associations between the consumption of turkey or poultry and what that dietary pattern means for periodontitis.   Quotes:    “Well, what we found in this massive study, almost 3000 individuals with varying stages of periodontitis, was that when these individuals adhered and strongly adhered to either the DASH diet or the Mediterranean diet, that we saw changes in their periodontitis levels.”   “So slice one more piece of turkey this Thanksgiving knowing that you're helping to address any potential periodontal inflammation in the oral cavity.”    Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/  Resource: Altun E, Walther C, Borof K, Petersen E, Lieske B, Kasapoudis D, Jalilvand N, Beikler T, Jagemann B, Zyriax BC, Aarabi G. Association between Dietary Pattern and Periodontitis - A Cross -Sectional Study. Nutrients. 2021 Nov 21;13(11):4167. doi: 10.3390/nu13114167. PMID: 34836422; PMCID: PMC8621734.  https://www.nhlbi.nih.gov/education/dash-eating-plan      

In this episode from the Endocrine Surgery team at BTK we discuss how Dr. Yeh built the section of endocrine surgery at UCLA. From Sydney, Australia to Santa Monica, he discusses the risks and challenges involved in becoming a leader in academic endocrine surgery. In this podcast we answer the question “why endocrine surgery,” and mention tips for success at all level of training from medical students to early faculty. Finally, we take a moment to honor and remember Dr. Orlo Clark.               Dr. Michael Yeh is a Professor of Surgery at UCLA and serves as Section Chief of the UCLA Endocrine Surgery program which he established.  Dr. Masha Livhits is an Assistant Professor of Surgery at UCLA and works in the Endocrine Surgery Department  Dr. James Wu is an Assistant Professor of Surgery at UCLA and works in the Endocrine Surgery Department  Dr. Na Eun Kim is an Endocrine Surgery Fellow at UCLA in her first year of fellowship Dr. Rivfka Shenoy is a PGY-6 General Surgery Resident at UCLA who has completed two years of research  Dr. Max Schumm is a PGY-6 General Surgery Resident at UCLA who has completed two years of research. He is a future endocrine surgeon.  Important Papers  Krishnamurthy VD, Gutnick J, Slotcavage R, Jin J, Berber E, Siperstein A, Shin JJ. Endocrine surgery fellowship graduates past, present, and future: 8 years of early job market experiences and what program directors and trainees can expect. Surgery. 2017 Jan;161(1):289-296. doi: 10.1016/j.surg.2016.06.069. Epub 2016 Nov 17. PMID: 27866719. Krishnamurthy VD, Jin J, Siperstein A, Shin JJ. Mapping endocrine surgery: Workforce analysis from the last six decades. Surgery. 2016 Jan;159(1):102-10. doi: 10.1016/j.surg.2015.08.024. Epub 2015 Oct 9. PMID: 26456130. Kulaylat AN, Kenning EM, Chesnut CH 3rd, James BC, Schubart JR, Saunders BD. The profile of successful applicants for endocrine surgery fellowships: results of a national survey. Am J Surg. 2014 Oct;208(4):685-9. doi: 10.1016/j.amjsurg.2014.03.013. Epub 2014 Jun 21. PMID: 25048570; PMCID: PMC4639920. Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.   If you liked this episode, check out other Endocrine Surgery episodes here: https://behindtheknife.org/podcast-category/endocrine/

What is antimicrobial resistance and how is it impacting us and our health? For more information checkout: Discovery and preclinical development of new antibiotics (PMID: 24646092), Five barriers to addressing antimicrobial resistance (Author: Rohan Kocharekar), CDC: Antibiotic Rsistance Threats in the United States 2019, National Strategy for Combating Antibioticresistant Bacteria (Obama Administration), National Action Plan for Combating Antibiotic-Resistant Bacteria 2020-2025 (ASPE), United States National Actiona Plan (CDC), Enhancing US-Japan Cooperation to Combat Antimicrobial Resistance (PMID: 25470465), A View on 20 Years of Antimicrobial Resistance in Japan by Two National Surveillance Systems: The National Epidemiological Surveillance of Infectious Diseases and Japan Nosocomial Infections Surveillance (PMID: 34680770), Estimating the Economic and Clinical Value of Reducing Antimicrobial Resistance to Three Gram-negative Pathogens in Japan (PMID: 34703834), Strategy on Antiobiotic Resistance Switzerland (StAR), Epidemiological aspects of non-human antibiotic usage and resistance: implications for the control of antibiotic resistance in Ghana (PMID: 22413809), Occurrence of Antibiotics and Antibiotic-Resistant Bacteria in Landfill Sites in Kumasi, Ghana (Article ID: 6934507), Determinants of Inappropriate Antibiotics Use in Rural Central Ghana Using a Mixed Methods Approach (PMID: 32266200), Resistance to antimicrobial drugs in Ghana (PMID: 22259250), Scoping Report on Antimicrobial Resistance in India, India's National Action Plan for antimicrobial resistance – An overview of the context, status, and way ahead (PMID: 31334140), Antimicrobial resistance in the environment: The Indian scenario (PMID: 31219076).

In today's podcast we talk about stress related to grief. One of the greatest stresses that we experience as humans and that is the loss of a loved one. Loss, stress and grief can also be related to the end of a relationship for example because of a divorce or a breakup or even the end of a friendship. It could be related to the loss of a job, needing to move homes or the loss of a pet.   The stages of grief are not necessarily linear; we can even go through all of them in a day.   We may feel denial, being in shock, anger, guilt and fear. We may also experience depression and sadness.    It's also important to allow ourselves to experience grief the way that it happens for each of us individually.   I want to share with you more about the research related to how loss and grief create stress on our bodies. In a study from 2012 they found there is definitely a change in our cortisol and adrenaline levels when we experience loss.1   One of the areas that I have been researching for over 20 years is measuring cortisol and adrenaline levels in myself and my patients and understanding how we are all unique in terms of how our cortisol and adrenaline shifts when we're under stress.   I find it very interesting that the studies on loss and death of a loved one showed that it's more common for cortisol and adrenaline to be elevated in the first two weeks to six months after the loss. A year after the loss, if people continue to have symptoms of grief, they are more likely to have low cortisol levels.    It's really important to know how your body is responding because then we can do something about it and recover. We can start regulating our adrenaline and cortisol levels so this doesn't become a long term or permanent issue.    We can work to reset the HPA Axis (hypothalamic pituitary adrenal axis) to tell our bodies to produce more or less cortisol and adrenaline and regulate our stress response.   Studies also show that when a person experiences loss, it can increase the likelihood of experiencing anxiety and depression. Also, our immune system can be affected, and we can experience higher levels of inflammation in the body.2   Many other health problems can develop when under high stress, such as insomnia, heart attacks, strokes, cancer, increased susceptibility to viruses, such as HPV, and other infections. There is even a condition known as broken heart syndrome, or Takotsubo, when the heart muscle is weakened from grief and severe stress.3   When we're in a grieving process that has disrupted our neuroendocrine (nervous system and hormones) is when we need to have our cortisol and adrenaline levels measured.    This is not done in the standard medical office so that's why I offer these tests through my office, so you can do them yourself at home. You can find these on the links below. Then you and I can meet, and I can help you understand your results and how to address them and use the right protocol of nutrients and herbs for you.   https://doctordoni.com/product/assess-your-stress-type/    And this is not a one-size-fits-all treatment. Not everyone needs the same nutrients and herbs. It is crucial that we understand how our bodies respond to stress as an individual, and what doses and supplements are needed for our bodies to start healing.     In my latest book “Master Your Stress, Reset Your Health” (https://doctordoni.com/master-your-stress/) I identified the correct sequence for helping you to get your cortisol, adrenaline and neurotransmitters back to optimal again, and it's based on what I refer to as your unique Stress Type.    Once we know your Stress Type, we can help you to efficiently implement the nutrients and herbs that will help bring your levels back to optimal.    -   You can find which is your unique Stress Type by taking my Stress Quiz here: https://doctordoni.com/quiz      I have also set up the stress type supplement bundles where you can get just the right supplements for your specific stress type. You can find these bundles in my store here: https://doctordoni.com/product-category/dr-doni-products/dr-doni-packages/    This is how passionate I am about helping you to recover from stress, including stress from loss of a loved one, so you can prevent the health issues associated with grief and so that you can be thriving in your life.    If I can be of more assistance, please don't hesitate to reach out to me to set up a one-on-one appointment if you prefer: https://doctordoni.com/work-with-me/    You can also check out my most recent free masterclass: Transform Your Life: Get to the Root of Anxiety and Depression: https://doctordoni.com/transformanxiety/#blank-1    We're here to help you!   -   References:    Buckley T, Sunari D, Marshall A, Bartrop R, McKinley S, Tofler G. Physiological correlates of bereavement and the impact of bereavement interventions. Dialogues Clin Neurosci. 2012 Jun;14(2):129-39. doi: 10.31887/DCNS.2012.14.2/tbuckley. PMID: 22754285; PMCID: PMC3384441.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384441/   Hopf, D, Eckstein, M, Aguilar-Raab, C, Warth, M, Ditzen, B. Neuroendocrine mechanisms of grief and bereavement: A systematic review and implications for future interventions. J Neuroendocrinol. 2020; 32:e12887. https://doi.org/10.1111/jne.12887   What is takotsubo cardiomyopathy?   https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy#:~:text=What%20is%20takotsubo%20cardiomyopathy%3F,extreme%20emotional%20or%20physical%20stress  -   Connect with Dr. Doni:    Facebook HTTPS://FACEBOOK.COM/DRDONIWILSON   Instagram HTTPS://INSTAGRAM.COM/DRDONIWILSON   YouTube HTTPS://YOUTUBE.COM/USER/DONIWILSONND   Weekly Wellness Wisdom Newsletter: HTTPS://DOCTORDONI.COM/WWW     -   Books and Resources:    Order My New Book: https://www.amazon.com/Master-Your-Stress-Reset-Health/dp/1953295576   Stress Warrior Book (FREE)  HTTPS://DOCTORDONI.COM/STRESSWARRIOR      Stress Warrior Stress Resiliency Facebook Group (FREE)  HTTPS://FACEBOOK.COM/GROUPS/STRESSWARRIOR     7-day Stress Reset (FREE)  HTTPS://DOCTORDONI.COM/STRESS-RESET     HPV & Cervical Dysplasia Guide (FREE)  HTTPS://DOCTORDONI.COM/HPV-AND-CERVICAL-DYSPLASIA-GUIDE/     -   Personalized Solutions:    If you'd like to meet with Dr. Doni one-on-one for your health, request a Health Breakthrough Session: HTTPS://DOCTORDONI.COM/BREAKTHROUGH     To get an idea of more comprehensive options, read about Dr. Doni's Signature Consultation Programs: HTTPS://DOCTORDONI.COM/SERVICES   Disclosure: Some of the links in this post are product links and affiliate links and if you go through them to make a purchase I will earn a commission at no cost to you. Keep in mind that I link these companies and their products because of their quality and not because of the commission I receive from your purchases. The decision is yours, and whether or not you decide to buy something is completely up to you.

Episode 116: Benefits of breastfeedingBy Timiiye Yomi, MD. Editing and comments by Hector Arreaza, MD.Dr. Yomi explains the benefits of breastfeeding for mother and baby. Three doctor listeners share their experiences with breastfeeding. You are listening to Rio Bravo qWeek Podcast, your weekly dose of knowledge brought to you by the Rio Bravo Family Medicine Residency Program from Bakersfield, California, a UCLA-affiliated program sponsored by Clinica Sierra Vista, Let Us Be Your Healthcare Home. This podcast was created for educational purposes only. Visit your primary care provider for additional medical advice.Breastfeeding is the process by which a child is fed breast milk. It is an ancient practice that dates to pre-historic times. The American Academy of Pediatrics recommends breastfeeding as the sole source of nutrition for babies for about 6 months and can be continued for as long as both mother and baby desire it, while the World Health Organization recommends exclusive breastfeeding for the first 6 months of life and up to 2 years with appropriate complementary foods.Human milk has many advantageous anti-infective and immunologic properties, making it the ideal nutritional source to optimize the infant's well-being. Of the over 130 million babies born every year in the world, only 42% of mothers breastfeed their newborn within the first hour of life, 38% practice exclusive breastfeeding, and over 50% breastfeed for up to 2 years. In this segment, we will be talking about the many benefits of breastfeeding to both children and mothers.Benefits to the baby: Breast milk has the right amount of nutrients and fluids needed for a baby's growth and development.It is easier to digest than formula, and breastfed babies have less gas, fewer feeding problems, and less constipation.It contains antibodies that protect infants from illnesses like otitis media, gastroenteritis, and respiratory illnesses like asthma and allergies, especially in children breastfed beyond 6 months. It reduces the risk of atopic dermatitis, NEC, Celiac Disease, Crohn's Disease and ulcerative colitis, Late-onset sepsis in the preterm infant, and childhood leukemia.Reduces the risk of childhood obesity, HTN, and type 1 and 2 diabetes  Breastfed infants have a lower risk of sudden infant death syndrome (SIDS).Breastfed infants have been shown to have better cognitive development.Benefits to the mother:Promotes weight loss and some degree of contraceptive for mothersWomen who breastfeed longer have been shown to have lower rates of type 2 diabetes and high blood pressure, breast and ovarian cancer in premenopausal women, thyroid cancers, rheumatoid arthritis, and osteoporosisReduces the risk of post-Partum depressionBreastfeeding triggers the release of oxytocin that promotes uterine involution and may decrease the amount of postpartum hemorrhage.Additional benefits:Promotes mother-infant bonding Cheap and economical for families and societyConvenientIn summary, breastfeeding delivers a lot of health, nutritional and emotional benefits to both children and mothers. When not contraindicated, we encourage mothers to engage in this practice as it presents babies with a healthy start in life.The benefits of breastfeeding cannot be overstated. However, we recognize that some mothers have challenges breastfeeding. For those mothers, we say you are a great mother if you take good care of your baby, even if you cannot breastfeed him/her.Testimonials:Breastfeeding is highly recommended by healthcare professionals, and in most cases, it is a natural and smooth process. However, it is not always free of challenges. You will listen to testimonials about three different breastfeeding experiences. All these testimonials are anonymous and written by advanced-level healthcare providers. Their experiences fall on a spectrum ranging from positive and easy to negative and difficult.Testimonial #1: My grandma told me so.When I was pregnant with my first child, I was already keenly aware of the benefits of breastfeeding because by that time, I was established in my profession as a health care provider. I looked forward to breastfeeding my newborn. However, when my baby was born, I found that my breast anatomy made it extremely difficult for my baby to latch on. While it is possible for women to breastfeed with inverted nipples, for me and my baby, it did not work out. I felt like a failure as a new mother.  When my grandma came to visit me and my newborn, I told her how frustrated I was with my body.  She replied, “yah, sorry about that; you got those from me!” Yes, inverted nipples are a genetic trait, and 10-20% of women are born with inverted nipples. I had been feeling alone in my plight, but after talking with my grandma, I realized there were other women struggling just like me!  Although I was very disappointed that I couldn't breastfeed, I didn't let that deter me from giving breast milk to my baby. Where there is a will, there is a way! I decided to bottle-feed my baby with my pumped breast milk. It was extra work and a bit time-consuming, but for me, the health benefits for both my baby and me were worth it. Thankfully, I am blessed with a supportive husband who took on the nighttime feedings while I pumped milk. I could only keep up this pumping routine for 3 months before my maternity leave ended. While I would have preferred my baby to receive breast milk for longer, I find peace in the saying, “something is better than nothing.” If only there had been wearable breast pumps back then, I'm sure I could have given my baby breast milk for much longer. Technology today is amazing!  While I encourage all my patients to breastfeed, my personal experience has made me empathetic to the physical challenges and even heartache that women experience over breastfeeding. I always keep in mind that every woman and baby's situation is unique, and I also give myself grace for what I initially felt was a shortcoming as a new mother.  Testimonial 2: Fed is best.I have been a breastfeeding advocate since medical school.Prior to the delivery of my first baby, I had my breast pump and bag ready. I had all the handouts about different breastfeeding techniques, positions, and all the available community resources.  I had the tablets and teas that would stimulate milk production. I was ready!When I delivered my beautiful baby girl, she had trouble latching and it was very painful for me. All through that first night at the hospital, I requested the lactation coaches to come to the bedside to guide me, and they came by every shift. They even gave me all these extra syringes and tubes to feed my baby. We ended up feeding her with donor's milk at the hospital. We even fed her via a syringe the first few nights. I was never able to get her to latch. I drank my water and my tea, I  took my tablets, and I was able to pump some milk,filling only 1/4 -1/2 of the bottle each time, only about 3-6 cc from each breast in a 20–30-minute session. My baby started to be fed with formula and my breast milk. I continued to pump during my lunch breaks when I returned to work. I did this until she turned 6 months old, then I stopped.My second baby was able to latch a few times in the hospital. I felt so relieved that I would be a successful breastfeeder, but she started to get jaundiced because of inadequate intake. We decided to give her donor milk again. At home, I still could not breastfeed, but I was able to pump. I even bought the hands-free Willow pump, thinking I could pump while charting or seeing patients, but it was not for me. My baby alternated feedings between breast milk and formula. I stopped pumping at 3 months.It was quite frustrating to not successfully latch and breastfeed. Somehow, I had this feeling as the song goes, “ I did my best, but I guess my best wasn't good enough”. Thankfully, one of my pediatric colleagues put my mind at ease. She said, “fed is best.” Indeed, my baby girls have grown to be beautiful, healthy babies, and our bond is strong. Now I counsel with grace and consideration. My  mantra before was “breast is best”; now, it is “fed is best.”Testimonial #3: A mother of seven.I had seven babies, and each of them had different experiences with breastfeeding. I'd like to share with you how it went. Breastfeeding my first baby was relatively easy. He was a cooperative, calm infant and caught on quickly to the process. Baby number two was 6 weeks premature, so in the first week, he kept falling asleep, but as he got a bit older, things went well. Baby number 3 was born with a cleft lip and alveolar ridge, and breastfeeding was necessary. The breast tissue filled up the cleft in his lip, so he was able to grow normally until big enough for reparative surgery. He did have a bit of nipple confusion when I had to return to work. Baby three actually continued some token breastfeeding for a couple of weeks when his newborn sister was co-nursing. Because the breast is a demand-organ, increased suckling increases milk productivity, so neither child was deprived of milk. Baby four adapted well.Baby five was a somewhat slow learner but, with persistence, ultimately did well. Baby six also was an eager learner, but when she was 9 months, decided that she had had enough of breastfeeding, so we stopped. Baby seven adapted too well and breastfed for a couple of years. Several babies were breastfed during my pregnancies without issues. In my opinion, the first week is when you must teach a baby how to breastfeed, and it is generally the most difficult. If you can tough it through that first week, things become a lot easier. Babies have their own personalities and their own way of learning, so whereas one baby will prove a natural at the task, another may require a bit more patience. Breastfeeding and working can be challenging, but I was able to continue breastfeeding and return to work. It took determination and the reversal of day and night feeds. I didn't get much sleep at first, but the babies stayed so much healthier due to the immune benefits of breastfeeding, which meant less time off work with a sick child!If you have a “special needs” baby, and this includes premies and children with orofacial problems, breastfeeding prevents nutritional issues. Breastfeeding provided me with a special feeling of tranquility and peace, that's why it may reduce the risk of postpartum depression. Also, the luxury of being able to feed anytime, anywhere, was very helpful for me!All seven of our kids have advanced degrees, and several have their doctorates. I would like to think that breast milk played a role in their academic success. I think breastfed babies are smarter! ____________________________Conclusion: Now we conclude episode number 116, “Benefits of breastfeeding.” We hope your knowledge about breastfeeding was enriched by Dr. Yomi's presentation and that the testimonials gave you a broader perspective on the breastfeeding experience. This week we thank Hector Arreaza, Timiiye Yomi, Chelsea Dunn, Carmen Ruby, Anna Stewart, and three anonymous doctor mothers. Audio edition by Adrianne Silva.Even without trying, every night, you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you. Send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week! _____________________Links: Madore LS, Fisher DJ. The Role of Breast Milk in Infectious Disease. Clin Perinatol. 2021 Jun;48(2):359-378. doi: 10.1016/j.clp.2021.03.008. PMID: 34030819. https://pubmed.ncbi.nlm.nih.gov/34030819/American Academy of Pediatrics. (2021). Benefits of breastfeeding, Patient Care. Retrieved from https://www.aap.org/en/patient-care/breastfeeding/breastfeeding-overview/Westerfield KL, Koenig K, Oh R. Breastfeeding: Common Questions and Answers. Am Fam Physician. 2018 Sep 15;98(6):368-373. PMID: 30215910. https://www.aafp.org/pubs/afp/issues/2018/0915/p368.htmlRoyalty-free music used for this episode: Gushito, Latin Pandora by Videvo, downloaded on May 06, 2022, from https://www.videvo.net

In this research review we are highlighting what Greg Nuckols has put together around the impact of sleep (or lack of it) on strength. The two studies below look at how sleep impacts strength and the findings weren't quite as big as you might have thought. We discuss what this means, how it applies and how you still want to focus on sleep to make sure it is a priority but also that you can still get work done if you fall short on any given night. Craven J, McCartney D, Desbrow B, Sabapathy S, Bellinger P, Roberts L, Irwin C. Effects of Acute Sleep Loss on Physical Performance: A Systematic and Meta-Analytical Review. Sports Med. 2022 Jun 16. doi: 10.1007/s40279-022-01706-y. Epub ahead of print. PMID: 35708888. Knowles OE, Drinkwater EJ, Urwin CS, Lamon S, Aisbett B. Inadequate sleep and muscle strength: Implications for resistance training. J Sci Med Sport. 2018 Sep;21(9):959-968. doi: 10.1016/j.jsams.2018.01.012. Epub 2018 Feb 2. PMID: 29422383. LINK: https://youtu.be/8y5XTtCvdXE #complicatedsimple #progressive #openminded #PBE #EBP #noagenda #performance #training #nutrition #health #wellness #athlete #athletictraining #science #chiropractic #rehab #prevention #clinicallypressed #phd --- Support this podcast: https://anchor.fm/clinicallypressed/support

Should you be practicing intermittent fasting (“IF”)? What are the health and performance benefits? Are you a good candidate for IF? Bob and Dina discuss these topics as one of their first episodes to cover fasting for athletes. Links to research: Zouhal H et al. Exercise Training and Fasting: Current Insights. Open Access J Sports Med. 2020 Jan 21;11:1-28. doi: 10.2147/OAJSM.S224919. PMID: 32021500; PMCID: PMC6983467. (https://pubmed.ncbi.nlm.nih.gov/32021500/) Correia JM at al. Effects of Intermittent Fasting on Specific Exercise Performance Outcomes: A Systematic Review Including Meta-Analysis. Nutrients. 2020 May 12;12(5):1390. doi: 10.3390/nu12051390. PMID: 32408718; PMCID: PMC7284994. (https://pubmed.ncbi.nlm.nih.gov/32408718/) Thank you to our podcast sponsor, InsideTracker, who provides you with a personalized plan to build endurance, boost energy and optimize your health for the long haul. Created by leading scientists in aging, genetics, and biometrics, InsideTracker analyzes your blood, DNA, and fitness tracking data to identify where you're optimized—and where you're not. You'll get a daily Action Plan with personalized guidance on the right exercise, nutrition, and supplementation for your body. Use the link insidetracker.com/isnpodcast or the code ISNPODCAST for a 20% savings on any of their testing panels. Check them out at www.insidetracker.com, on Instagram @insidetracker and Facebook at InsideTracker This episode is also brought to you by All Around Snack Co., founded by Sport Dietitian, Bob Seebohar. All Around Snack Co. has super tasty snacks that are low in added sugars, contain zero dyes, colorings or additives and help control blood sugar for steady energy levels throughout the day. Perfect for kids, families, athletes and everyone in between! Check out Gourmet Snack Mix, ENRG BITES, or Protein Puffs at www.allaroundsnackco.com and use the code ISNPODCAST22 for 15% off your order at the All Around Snack Co. website. Learn about Bob and Dina's services and programs at www.enrgperformance.com and www.nutritionmechanic.com.

High fructose corn syrup (HFCS) is most likely something you have heard of before. If you look at food labels, you DEFINETELY have seen it listed in ingredients. It's found in many commonly eaten foods and beverages. In fact, HFCS represents around 40% of sweeteners consumed in the U.S. So with something so prevalent we must ask, what is it doing to our health? In this episode we talk about: - Why was HFCS added to foods? -What's the difference between HFCS and sugar? - Does HFCS cause health issues? - Who should be most concerned about HFCS in their food? - Why should you be on the look out for HFCS on labels when it comes to your health. Mentioned in this episode: References: Della Corte KW, Perrar I, Penczynski KJ, Schwingshackl L, Herder C, Buyken AE. Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies. Nutrients. 2018 May 12;10(5):606. doi: 10.3390/nu10050606. PMID: 29757229; PMCID: PMC5986486. Febbraio MA, Karin M. "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab. 2021 Dec 7;33(12):2316-2328. doi: 10.1016/j.cmet.2021.09.004. Epub 2021 Oct 6. PMID: 34619076; PMCID: PMC8665123. The American Journal of Clinical Nutrition, Volume 88, Issue 6, December 2008, Pages 1716S–1721S, https://doi.org/10.3945/ajcn.2008.25825B The Cleveland Clinic. Avoid the hidden dangers of high fructose corn syrup. 2020. Retrieved from: https://health.clevelandclinic.org/avoid-the-hidden-dangers-of-high-fructose-corn-syrup-video/ U.S. Food and Drug Administration. High Fructose Corn Syrup Questions and Answers. 2018. Retrieved from: https://www.fda.gov/food/food-additives-petitions/high-fructose-corn-syrup-questions-and-answers More fun stuff: - The ULTIMATE Smoothie Guide- CLICK HERE - Sugar Reset Mini Course- Click HERE - Schedule a free 20 minute consultation HERE! - Connect on FACEBOOK or INSTAGRAM Do you like this podcast? Please make sure to leave a review wherever you listen to podcasts and share it with someone who would benefit from listening!

Deric Poston, Ehsan Ahmad, John Deas, Paul Deemer, D Madness, Michael A. Gonzales, Jules Durel, Joe White, Kristie Nova, Yoni, Tony Hinchcliffe, Brian Redban – 10/10/2022–THIS EPISODE IS SPONSORED BY:LIQUID-IV.COM – GET 25% OFF ANY ORDER WITH PROMO CODE: “TONY” AT: LIQUID-IV.COM—Kimpton Hotel Van Zandt – Save on Sunday and Monday nights when you stay at Hotel Van Zandt using this link: CLICK HERE!

Back to exploring the soft skill of being teachable….  Learning, Unlearning, Relearning: Part 2 “The illiterate of the 21st century will not be those who cannot read and write, but those who cannot learn, unlearn and relearn. “Alvin Toffler Why is unlearning is more difficult than learning? First, learning is not implemented through a google search or a new app.  Unlearning comes through self-awareness and networking with others to gain new insights and knowledge. Unlearning includes the “people factor” The second reason unlearning is so difficult is that fear rises within when faced with the unknown. When you engage in unlearning you move outside of your comfort zone.  “If we are growing, we will always be out of our comfort zone” John Maxwell Third, with unlearning. you are moving away from the security of knowledge that has been helpful to you in the past.  Fourth, there may be a reluctance to say goodbye to short cuts that have been helpful in the past. Finally, it may be difficult to even want to unlearn, when you think you are functioning adequately on a daily basis and are getting by.  Researcher, Dr Chris Robitscheck, has demonstrated that one of the key elements of personal growth is being ready to change. This cycle of learning, unlearning and relearning moves you into a ready stance for change! THE LEARNING PROCESS REQUIRES SELF AWARENESS: THE UNLEARNING PROCESS REQUIRES A PASSION FOR SIMPLICITY: Keep it simple:  1. Pick one thing. 2. Ask yourself, “Am I willing to let it go of this thing?”  3. Ask yourself (and others) “What is the opposite of the one thing I've picked?”. Confirming the opposite of the thing moves you towards your readiness to relearn. THE RELEARNING PROCESS REQUIRES FOCUSED EXPLORATION:  Focus on asking 2 key questions: 1. What do I want to change? 2. What do I value that will sustain the change. We do need to know ourselves but even the most self-aware leader knows that we need others as well. Collaboration is where the future always is.  Carlos Dominguez. Resources: Reach out to me @ https://www.healthyleadership.online/contact (https://www.healthyleadership.online/contact)  I can help you in your own growth as a leader. Robitschek C, Ashton MW, Spering CC, Geiger N, Byers D, Schotts GC, Thoen MA. Development and psychometric evaluation of the Personal Growth Initiative Scale-II. J Couns Psychol. 2012 Apr;59(2):274-87. doi:10.1037/a0027310. Epub 2012 Feb 20. PMID: 22352950. Seth's Blog: The Speed Of Change 9.2022 @ https://seths.blog/2022/09/the-speed-of-change/ (https://seths.blog/2022/09/the-speed-of-change/) Transactions of the American Clinical and Climatological Association @ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116346/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116346/)

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-299 Overview: Polypharmacy is a burden on patients with dementia. Adverse drug reactions, side effects, the cost, and inappropriate medications that may lead to falls and morbidity/mortality may be conferring more harm than benefit. Unfortunately, 44% of men and 57% of women >65 years take five or more nonprescription and/or prescription medications per day. Join us as we discuss methods for deprescribing polypharmacy in this patient population.  Episode resource links: Growdon, M. E., Gan, S., Yaffe, K., & Steinman, M. A. (2021). Polypharmacy among older adults with dementia compared with those without dementia in the United States. Journal of the American Geriatrics Society, 69(9), 2464–2475. PMID: 34101822 https://doi.org/10.1111/jgs.17291 Narayan, S. W., & Nishtala, P. S. (2017). Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review. Drugs & aging, 34(10), 767–776. PMID: 28853000  https://doi.org/10.1007/s40266-017-0487-1 Guest: Jill M. Terrien PhD, ANP-BC    Music Credit: Richard Onorato  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-299 Overview: Polypharmacy is a burden on patients with dementia. Adverse drug reactions, side effects, the cost, and inappropriate medications that may lead to falls and morbidity/mortality may be conferring more harm than benefit. Unfortunately, 44% of men and 57% of women >65 years take five or more nonprescription and/or prescription medications per day. Join us as we discuss methods for deprescribing polypharmacy in this patient population.  Episode resource links: Growdon, M. E., Gan, S., Yaffe, K., & Steinman, M. A. (2021). Polypharmacy among older adults with dementia compared with those without dementia in the United States. Journal of the American Geriatrics Society, 69(9), 2464–2475. PMID: 34101822 https://doi.org/10.1111/jgs.17291 Narayan, S. W., & Nishtala, P. S. (2017). Discontinuation of Preventive Medicines in Older People with Limited Life Expectancy: A Systematic Review. Drugs & aging, 34(10), 767–776. PMID: 28853000  https://doi.org/10.1007/s40266-017-0487-1 Guest: Jill M. Terrien PhD, ANP-BC    Music Credit: Richard Onorato