Podcasts about cardiovascular events

Editor's Summary by Kirsten Bibbins-Domingo, PhD, MD, MAS, Editor in Chief, and Preeti Malani, MD, MSJ, Deputy Editor of JAMA, the Journal of the American Medical Association, for articles published from February 1-7, 2025.

Dr. Baxter Montgomery and Dr. Nathan S. Bryan delve into the synergy between nitric oxide and plant-based nutrition. Learn how this powerful combination can enhance health and wellness. #NitricOxide #PlantBasedNutrition #HealthSynergy

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on the Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events in a Multicenter Study.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Estimating the Risk of Cardiovascular Events in U.S. Veterans Using the SMART Risk Score.

❤️ Bonjour,Bienvenue dans cet épisode consacré au syndrome d'apnées obstructives du sommeil !

Commentary by Dr. Jian'an Wang.

I had an eye-opening discussion with environment and health expert, Dr. Ian Mudway about the prevalence and risks of microplastics in our everyday lives. How do we consume microplastics? Are they a danger to our health? How can we lessen the exposure of microplastics? Tune in to answer all these questions and more!  

Sodium (and salt for that matter) has been made out to be the villain when it comes to nutrition. In fact, without sodium, you wouldn't be alive. While high amounts of salt in the diet are related to high blood pressure, the evidence to support a link with heart and other diseases isn't clear. In this episode we discuss why you need sodium, how much is too much, is sodium as harmful as we're told and how getting more potassium can help.   References cited in this podcast: Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events: https://www.nejm.org/doi/full/10.1056/NEJMoa1311889 Sources of potassium in food: https://www.dietaryguidelines.gov/food-sources-potassium  

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on associations between physical activity patterns and cardiovascular events and risk factors.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on cardiovascular events risk in office-masked nocturnal hypertension defined by home blood pressure monitoring.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on AI prediction of cardiovascular events using opportunistic epicardial adipose tissue assessments from computed tomography calcium score.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances discusses a recently published original research paper on Interleukin-6 and Cardiovascular Events in Healthy Adults in the Multi-Ethnic Study of Atherosclerosis

Commentary by Dr. Candice Silversides

The average person consumes 39 000 to 52 000 microplastic particles per year through food and drink. This number doubles when taking into account how many microplastics we might inhale. Microplastics have been found in blood samples and almost every organ in the human body. In this episode, we discuss what are microplastics, how they get into your body, how they affect your health and how to avoid being exposed to them.   References cited in this podcast: Human Consumption of Microplastics: https://pubs.acs.org/doi/10.1021/acs.est.9b01517 Polypropylene microplastics promote metastatic features in human breast cancer: https://www.nature.com/articles/s41598-023-33393-8 Microplastics and Nanaoplastics in Atheromas and Cardiovascular Events: https://www.nejm.org/doi/full/10.1056/NEJMoa2309822

The average person sits for more than 6-8 hours. While we can't avoid sitting (and sometimes it's necessary), most of us do too much and continuous sitting can increase your risk for disases such as diabetes, heart disease, cancer and dementia, and early death. In this episode we discuss the problems with sitting, how it affects your metabolism, can your exercise counteract sitting and provide you with tips on how to reduce your sitting.   References cited in this podcast: Association of Sitting Time with Mortality and Cardiovascular Events in High-Income, Middle-Income and Low-Income Countries: https://jamanetwork.com/journals/jamacardiology/article-abstract/2793521 Device-measured physical activity, sedentary time, and risk of all-cause mortality: An individual participant analysis of four prospective cohort studies: https://bjsm.bmj.com/content/57/22/1457 Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses: https://diabetesjournals.org/care/article/35/5/976/38374/Breaking-Up-Prolonged-Sitting-Reduces-Postprandial  

A new study adds more doubt to the value of fish oil supplementation for heart disease prevention. Nutrition Diva is hosted by Monica Reinagel, MS, LDN. Transcripts are available at Simplecast.Have a nutrition question? Send an email to nutrition@quickanddirtytips.com or leave a voicemail at 443-961-6206.Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. Find Monica's blog and other programs at Nutrition Over Easy. Nutrition Diva is a part of the Quick and Dirty Tips podcast network. LINKS:Transcripts: https://nutrition-diva.simplecast.com/episodes/Facebook: https://www.facebook.com/QDTNutrition/Newsletter: https://www.quickanddirtytips.com/nutrition-diva-newsletterNutrition Over Easy: https://nutritionovereasy.comQuick and Dirty Tips: https://quickanddirtytipscom

In this podcast, Bahram Mohajer, MD, MPH, explores the study by Park et al. on the use of AI models to automate the evaluation for coronary artery calcification on low-dose lung cancer screening CT scans, as well as the correlation of AI findings with major adverse cardiovascular events. ARTICLE TITLE - Coronary Artery Calcification on Low-Dose Lung Cancer Screening CT in South Korea: Visual and Artificial Intelligence-Based Assessment and Association with Cardiovascular Events

Effect Of Edetate Disodium Based Chelation Infusions On Cardiovascular Events In Post-MI Patients With Diabetes: The TACT2 Trial

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update   discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.  This issue will review: 1.     Loneliness and the risk of type 2 diabetes 2.     Microplastics and Nanoplastics in Atheromas and Cardiovascular Events 3.     Tirzepatide vs Insulin Glargine by BMI 4.     Influence of a diet and/or exercise intervention on long-term mortality and vascular complications in people with impaired glucose tolerance 5.     Timing of moderate-to-vigorous physical activity, mortality, cardiovascular disease, and microvascular disease in adults with obesity and type 2 diabetes For more information about each of ADA's science and medical journals, please visit www.diabetesjournals.org. Hosts: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

ACC.24: BE ACTIVE Trial - Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events

What does the term "microplastics" mean to you? Why is seemingly everyone talking about them lately?  A new study published on March 6th in the New England Journal of Medicine titled, “Microplastics and Nanoplastics in Atheromas and Cardiovascular Events" has been circulating around the internet, and raises concerns about the risk of exposure to microplastics and long-term adverse health outcomes. What does this study suggest? What does the other data about microplastics show? Our exposure to plastics is ubiquitous; its in our packaging, our clothing, in our air and water. The chemical additives used in plastics manufacturing are also worrisome, as they have demonstrated adverse health effects in animal models. As we have hammered home in many prior episodes, DOSE and EXPOSURE matter when it comes to risk of harm from a particular substance. The same rules seem to apply for microplastics. In today's episode, Jeremy explains what we do and don't know about the risks of long term exposure to microplastics. He ends with some actionable items on how you can choose to limit your exposure with some simple daily behavioral changes. Resources for this episode include: The very recent NEJM article titled "Microplastics and Nanoplastics in Atheromas and Cardiovascular Events". A 2022 Frontiers in Endocrinology study regarding endocrine changes in mammals related to exposure to micro/nano plastics. A May 2023 article from National Geographic titled "Microplastics are in our bodies. How much do they harm us?" A March 19th, 2024 Everyday Health article on microplastics. An EcoWatch article titled "10 Simple Ways to Avoid Microplastics in Your Everyday Life". Thanks for tuning in, folks! Please sign up for our "PULSE CHECK" monthly newsletter! Signup is easy, right on our website page, and we PROMISE we will not spam you! We just want to send you cool articles, videos and thoughts :) For more episodes, limited edition merch, or to become a Friend of Your Doctor Friends (and more), follow this link!   Find us at: Website: yourdoctorfriendspodcast.com  Email: yourdoctorfriendspodcast@gmail.com  Connect with us: @your_doctor_friends (IG) Send/DM us a voice memo/question and we might play it on the show! @yourdoctorfriendspodcast1013 (YouTube) @JeremyAllandMD (IG, FB, Twitter) @JuliaBrueneMD (IG) @HealthPodNet (IG)

Commentary by Dr. Sadeer Al-Kindi and Dr. Allan Sniderman

A Rebelião Saudável nasceu da união de diversos profissionais de saúde que pensam diferente e cujo foco é promover saúde e bem estar, com comida de verdade e sem medicamentos. Semanalmente a Rebelião se reune no app Telegram para discussão de tópicos importantes relacionados a Nutrição Humana e Qualidade de vida. Nessa semana, a Rebelião discutiu sobre Microplásticos e Saúde. Referências citadas no Podcast: Marfella R, Prattichizzo F, Sardu C, Fulgenzi G, Graciotti L, Spadoni T, D'Onofrio N, Scisciola L, La Grotta R, Frigé C, Pellegrini V, Municinò M, Siniscalchi M, Spinetti F, Vigliotti G, Vecchione C, Carrizzo A, Accarino G, Squillante A, Spaziano G, Mirra D, Esposito R, Altieri S, Falco G, Fenti A, Galoppo S, Canzano S, Sasso FC, Matacchione G, Olivieri F, Ferraraccio F, Panarese I, Paolisso P, Barbato E, Lubritto C, Balestrieri ML, Mauro C, Caballero AE, Rajagopalan S, Ceriello A, D'Agostino B, Iovino P, Paolisso G. Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. N Engl J Med. 2024 Mar 7;390(10):900-910. doi: 10.1056/NEJMoa2309822. PMID: 38446676. Völker J, Ashcroft F, Vedøy Å, Zimmermann L, Wagner M. Adipogenic Activity of Chemicals Used in Plastic Consumer Products. Environ Sci Technol. 2022 Feb 15;56(4):2487-2496. doi: 10.1021/acs.est.1c06316. Epub 2022 Jan 26. PMID: 35080176; PMCID: PMC8851687. Martínez Steele E, Khandpur N, da Costa Louzada ML, Monteiro CA. Association between dietary contribution of ultra-processed foods and urinary concentrations of phthalates and bisphenol in a nationally representative sample of the US population aged 6 years and older. PLoS One. 2020 Jul 31;15(7):e0236738. doi: 10.1371/journal.pone.0236738. PMID: 32735599; PMCID: PMC7394369. https://revistapesquisa.fapesp.br/os-impactos-dos-microplasticos-sobre-a-saude-humana/ Você também pode participar da discussão e da Rebelião. Toda Segunda feira, às 7:00, estaremos ao vivo no Telegram, basta acessar o nosso canal: https://t.me/RebeliaoSaudavel. Se você gosta de nosso trabalho, deixe um review 5 estrelas e faça um comentário no seu app de podcast. Essa atitude é muito importante para a Rebelião saudável e vai ajudar nosso movimento a chegar a cada vez mais pessoas. Você também pode nos acompanhar no instagram, http://www.instagram.com/henriqueautran. E em nosso canal do YouTube: https://youtube.com/c/henriqueautran.

Strong body, strong mind, is a common saying, but the reverse can be true too. How you think can affect your physical health because each and every thought you have is the result of a chemical reaction. In this episode, we discuss how certain thoughts affect performance and health, what happens in your body to make this happen and how to shift to a more positive way of thinking.   Some references cited in the podcast: Association of Optimism with Cardiovascular Events and All-Cause Mortality https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2752100 Become More Optimistic by Imagining a Best Possible Self https://www.sciencedirect.com/science/article/abs/pii/S0005791611000358?via%3Dihub Interactions of momentary thought content and subjective stress predict cortisol fluctuations in a daily life experience sampling study https://www.nature.com/articles/s41598-018-33708-0    

Commentary by Dr. Candice Silversides

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

This is a recording from the live webinar was conducted live December 13, 2023. This is an annual event that is held every year in mid-December celebrating the top hair research studies.    DERMATOPATHOLOGY   Douglas A et al. Scalp Biopsy Influences Diagnostic Accuracy and Treatment in Black Women with Alopecia: A Retrospective Study. J Am Acad Dermatol. 2023 Jan 31;S0190-9622(23)00157-3.   ANDROGENETIC ALOPECIA Gupta AK et al.The relative efficacy of monotherapy with 5-alpha reductase inhibitors and minoxidil for female pattern hair loss: A network meta-analysis study. J Cosmet Dermatol. 2023 Jun 29 Jimenez-Cauhe J et al. Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients. Actas Dermosifiliogr. 2023 Aug 29:S0001-7310(23)00679-8.   ALOPECIA AREATA   Gandhi et al.The Association of Alopecia Areata-Related Emotional Symptoms with Work Productivity and Daily Activity Among Patients with Alopecia Areata. Dermatol Ther (Heidelb). 2023 Jan;13(1):285-298.   Li SJ et al. Experiencing Workplace Bullying in Patients with Alopecia Areata: A Cross-Sectional Survey Study. Skin Appendage Disord. 2023 Aug;9(4):258-261   Kazmi A et al. Switching between tofacitinib and baricitinib in alopecia areata: A review of clinical response. J Am Acad Dermatol. 2023 Apr 4;S0190-9622(23)00532-7.   King B et al. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b-3 trial. Lancet. 2023 May 6;401(10387):1518-1529.   George P et al. Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database., Dermatol Ther (Heidelb). 2023 Aug; 13(8): 1733–1746.   Wang C-W et al. Clinical characteristics and immune profiles of patients with immune-mediated alopecia associated with COVID-19 vaccinations. Clin Immunol. 2023 Oct:255:109737.   Chen J et al. The Incidence of Alopecia Areata in a COVID-19- Vaccinated Population: A Single-Center Review. Cureus 2023   TELOGEN EFFLUVIUM   Michelini S et al. Telogen Effluvium in SARS-CoV-2 Infection: histological aspects. J Eur Acad Dermatol Venereol. 2023 Mar 8.   TINEA CAPITIS Gold, JA et al. Inadequate diagnostic testing and systemic antifungal prescribing for tinea capitis in an observational cohort study of 3.9 million children, United States. J Am Acad Dermatol. 2023 Feb 15;S0190-9622(23)00189-5.   COSMETIC DERMATOLOGY Landau M et al. Nonscarring alopecia after temporal lifting technique with dermal fillers. JAAD Case Rep. 2023 May 12;37   FOLLICULITIS DECALVANS Matard B et al. Folliculitis decalvans and dystrophic epidermolysis bullosa: a significant association. Br J Dermatol 2022 Dec;187(6):1026-1028. DISCOID LUPUS Fredeau L et al. Risk factors of progression from discoid lupus to severe systemic lupus erythematosus: a registry-based cohort study of 164 patients. J Am Acad Dermatol. 2023 Mar;88(3):551-559.   DISSECTING CELLULITIS Cajas-Garcia MS et al.  Distinct presentations of scalp dissecting cellulitis manifesting with furrows and gyri. J Eur Acad Dermatol Venereol. 2023 Feb 3.   LICHEN PLANOPILARIS Lim SH et al. Prevalence and Incidence of Comorbid Diseases and Mortality Risk Associated with Lichen Planopilaris: A Korean Nationwide Population-Based Study. Clin Exp Dermatol. 2023 Jul 11;llad235 GENERAL SCARRING ALOPECIA Kim SR et al.  Association of Primary Cicatricial Alopecia with Subsequent Cardiovascular Disease. J Invest Dermatol. 2023 Nov 19:S   CENTRAL CENTRIFUGAL CICATRICIAL ALOPECIA Joshi TP et al.  Comorbidities in patients with central centrifugal cicatricial alopecia: a case-control study. Int J Dermatol. 2023 Nov 23.   ACNE KELOIDALIS NUCHAE Lobato-Berezo A et al. Acne keloidalis nuchae: An international multicentric review of 79 patients. J Eur Acad Dermatol Venereol. 2023 Nov 1.

Commentary by Dr. Catherine Lee & Richard Cheng

Commentary by Dr Hirotoshi Watanabe

Links: Go to episode page (with study links) Subscribe to PREMIUM Receive our email newsletter About This Episode: The Oslo Diet-Heart Study was one of the earliest randomized controlled trials to explore the relationship between diet and heart disease. It aimed to investigate the impact of dietary interventions, specifically the reduction of saturated fat intake and an increase in polyunsaturated fat intake, on cardiovascular health. The Oslo Diet-Heart Study involved 412 men who had already suffered a myocardial infarction 1-2 years before the start of the intervention. Despite some known limitations, the Oslo Diet-Heart Study played a role in shaping early understanding on the relationship between dietary fat, cholesterol levels, and heart disease. Subsequent research and larger studies have contributed to a more nuanced understanding of the complex factors influencing cardiovascular health. In this episode we discuss why this trial is important in the history of diet-heart research and how it connects to other seminal work in the field.

Commentary by Dr. Candice Silversides

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

Commentary by Dr. Valentin Fuster

STUDIES REFERENCE IN THE EPISODE   SWITCHING FROM TOFACITINIB TO BARICITINIB   Kazmi A et al (starts at 12:33). Switching between tofacitinib and baricitinib in alopecia areata: A review of clinical response. J Am Acad Dermatol. 2023 Apr 4;S0190-9622(23)00532-7.     RITLECITINIB IN ADOLESCENTS   Hordinsky M et al (starts at 21:31). Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double-blind, placebo-controlled trial. Pediatr Dermatol. 2023 Jul 17.     RISK OF INFECTIONS, CANCER, HEART DISEASE AND BLOOD CLOTS IN AT/AU   George P et al (starts at 36:08). Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database., Dermatol Ther (Heidelb). 2023 Aug; 13(8): 1733–1746.     Schneeweiss MC et al (starts at 37:36). Incidence of Venous Thromboembolism in Patients With Dermatologist-Diagnosed Chronic Inflammatory Skin Diseases. JAMA Dermatol. 2021 Jul 1;157(7):805-816.     MARKERS OF VENOUS THROMBOEMBOLISM IN ALOPECIA AREATA   Sudnik W et al (starts at 57:40) . The role of selectins in alopecia areata. Postepy Dermatol Alergol. 2015 Feb;32(1):27-32.   Shakoei S et al (starts at 58:23). Coagulation status in patients with alopecia areata: a cross-sectional study. Ital J Dermatol Venerol. 2021 Oct;156(5):588-592.   Waśkiel-Burnat A et al (starts at 59:30). Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There Anything to Worry about? Dermatol Ther (Heidelb). 2023 Aug;13(8):1847-1855.     HABIT REPLACEMENT THERAPY FOR TRICHOTILLOMANIA   Moritz S et al (starts at 1:04:34). Self-Help Habit Replacement in Individuals With Body-Focused Repetitive Behaviors: A Proof-of-Concept Randomized Clinical Trial.  JAMA Dermatol. 2023 Jul 19;e232167.   LINK TO VIDEO on HRT DEMONSTRATION https://clinical-neuropsychology.de/habit-replacement-en/#sthash.J6iQiYRi.dpuf    

Howie and Harlan are joined by Julius Chapiro to discuss advances in the use of machine learning and molecular imaging to understand and treat liver cancer and his work as the director of Yale's Center for Minimally Invasive Therapies. Harlan reports on a medical journal paper that highlights positive outcomes while ignoring negative ones; Howie warns of the impact of private equity ownership of medical practices. Links: “MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features” “Froedtert & the Medical College of Wisconsin - Liver Cancer Minimally Invasive Therapies” ”Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning” “Comparison of Existing Response Criteria in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using a 3D Quantitative Approach” “Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients” “Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients” “Monetizing Medicine: Private Equity And Competition In Physician Practice Markets” Learn more about the MBA for Executives program at Yale SOM. Email Howie and Harlan comments or questions.

Bempedoic acid is an effective option for some statin-intolerant patients with an elevated predicted risk of cardiovascular events. However, as JAMA Executive Editor Gregory Curfman, MD, discusses with editorialist Dhruv S. Kazi, MD, MSc, MS, bempedoic acid should not be considered a substitute for statins, which remain the first-line therapy for primary prevention. Related Content: Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease

European HTN Guidelines, vitamin D, bempedoic acid, and leadless pacing, with some critical appraisal techniques thrown in, are the topics John Mandrola, MD, tackles in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. European Hypertension Guidelines New ESH Hypertension Guidelines Aim for Simplified Message https://www.medscape.com/viewarticle/993913 - 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH) https://pubmed.ncbi.nlm.nih.gov/37345492/ II. Vitamin D CV Benefit From Vitamin-D Caps Hinted in Huge D-Health Trial https://www.medscape.com/viewarticle/993996 - Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial https://www.bmj.com/content/381/bmj-2023-075230 - Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials https://jamanetwork.com/journals/jamacardiology/fullarticle/2735646 III. Bempedoic Acid 'Striking' Benefit of Lipid Lowering in Primary Prevention https://www.medscape.com/viewarticle/993666 - Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients https://jamanetwork.com/journals/jama/fullarticle/2806646 - Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease https://jamanetwork.com/journals/jama/fullarticle/2806647 - Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients https://www.nejm.org/doi/full/10.1056/NEJMoa2215024 IV. Leadless Pacing FDA Approves First Leadless Dual-Chamber Pacing System https://www.medscape.com/viewarticle/994033 - A Dual-Chamber Leadless Pacemaker https://www.nejm.org/doi/full/10.1056/NEJMoa2300080 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-335 Overview: In this episode, we review recent updates from the Diabetes Prevention Program (DPP) trial and Diabetes Prevention Program Outcomes Study (DPPOS). Join us as we discuss the impact of the updates on diabetes prevention strategies for cardiovascular outcomes. Episode resource links: Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*. Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study. Circulation. 2022 May 31;145(22):1632-1641. doi: 10.1161/CIRCULATIONAHA.121.056756. Epub 2022 May 23. PMID: 35603600; PMCID: PMC9179081. Galaviz KI, Weber MB, Suvada K BS, Gujral UP, Wei J, Merchant R, Dharanendra S, Haw JS, Narayan KMV, Ali MK. Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis. Am J Prev Med. 2022 Apr;62(4):614-625. doi: 10.1016/j.amepre.2021.10.020. Epub 2022 Feb 10. PMID: 35151523. Guest: Jillian Joseph, MPAS, PA-C   Music Credit: Richard Onorato

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-335 Overview: In this episode, we review recent updates from the Diabetes Prevention Program (DPP) trial and Diabetes Prevention Program Outcomes Study (DPPOS). Join us as we discuss the impact of the updates on diabetes prevention strategies for cardiovascular outcomes. Episode resource links: Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*. Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study. Circulation. 2022 May 31;145(22):1632-1641. doi: 10.1161/CIRCULATIONAHA.121.056756. Epub 2022 May 23. PMID: 35603600; PMCID: PMC9179081. Galaviz KI, Weber MB, Suvada K BS, Gujral UP, Wei J, Merchant R, Dharanendra S, Haw JS, Narayan KMV, Ali MK. Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis. Am J Prev Med. 2022 Apr;62(4):614-625. doi: 10.1016/j.amepre.2021.10.020. Epub 2022 Feb 10. PMID: 35151523. Guest: Jillian Joseph, MPAS, PA-C   Music Credit: Richard Onorato

In episode 537, Mike and James invite Ricky Turgeon back to the podcast to talk about the impact of the influenza vaccination on cardiovascular events in both primary and secondary prevention. The best evidence is in secondary prevention. Tune-in to hear the numbers. Show Notes 1) Tools for Practice A Jab for Your CAD: Influenza […]

As I was creating a swipe/carousel post for Instagram on this topic, there was way too much I wanted to try and include and wanted to do a deep dive on this potential controversial topic on weight loss drugs. We've seen the rise in popularity of these drugs and injections and I am concerned with how it is being prescribed especially to our younger population. I'll share some statistics, studies, my thoughts, and more on this topic and please let me know what you think!   Time Stamps:   (0:28) Inspired By an Instagram Post I Worked On Today (2:27) Weight Loss Drugs/Injections (4:00) Caveats/My Concerns (6:23) Mechanisms of These Weight Loss Drugs (8:14) Common Side Effects (13:50) Problems with Overprescribing (22:13) Opening Up the Conversation (23:50) No Exit Plan (27:47) Side Effect of Muscle Loss (45:00) Muscle Loss and Cardiovascular Events (49:20) My Stance is One of Concern (52:14) Please Send Me a DM (54:00) Please Share and Rate! --------------------- Studies Mentioned in This Episode: https://pubmed.ncbi.nlm.nih.gov/36721154/ https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 https://link.springer.com/article/10.1007/s00125-019-05065-8 --------------------- Where You Can Find Me: @joellesamantha Nutrition & Fitness Coaching: @leveltencoaching Fitness Coaching Software: @fitcoachpro

Dr. Paul Alexander Liberty Hour – Why is the optimal health of females being sidelined this way? Females are at as much risk, if not more than males, due to the COVID mRNA technology gene injection vaccine. The science has matured and is telling us this. Be warned, women, do not let the medical doctors fool you anymore!

ERASE AF follow-up, recreational drugs and AF, etripamil, misuse of science, and diabetes as a cardiovascular risk factor are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Follow-up on ERASE AF II. Recreational Drugs Four Commonly Abused Drugs Linked With Atrial Fibrillation https://www.medscape.com/viewarticle/983052 III. Etripamil RAPID: Positive Data for Etripamil Nasal Spray in Paroxysmal SVT https://www.medscape.com/viewarticle/982787 - Milestone Pharmaceuticals Announces Positive Results from Phase 3 RAPID Clinical Trial of Etripamil Nasal Spray in Patients with Paroxysmal Supraventricular Tachycardia https://investors.milestonepharma.com/news-releases/news-release-details/milestone-pharmaceuticals-announces-positive-results-phase-3 IV. Misuse of Science When Bad Actors Hijack Good Research https://www.medscape.com/viewarticle/982936 - Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/31050775/ V. Diabetes as a Risk Factor Diabetes Becoming Less Potent Risk Factor for CVD Events https://www.medscape.com/viewarticle/982801 - Trends in the Association Between Diabetes and Cardiovascular Events, 1994-2019 https://jamanetwork.com/journals/jama/fullarticle/2797494 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

The ERASE AF ablation trial, left bundle pacing, finerenone, and perceptions of cardiology are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. AF Ablation - Low-Voltage Myocardium-Guided Ablation Trial of Persistent Atrial Fibrillation https://evidence.nejm.org/doi/10.1056/EVIDoa2200141 - Approaches to Catheter Ablation for Persistent Atrial Fibrillation https://www.nejm.org/doi/full/10.1056/NEJMoa1408288 - Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2793452 - Circumferential Pulmonary Vein Isolation Plus Low-Voltage Area Modification in Persistent Atrial Fibrillation: The STABLE-SR-II Trial https://www.jacc.org/doi/full/10.1016/j.jacep.2022.03.012 - Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation https://jamanetwork.com/journals/jama/fullarticle/2772281 - Hybrid Convergent Procedure for the Treatment of Persistent and Long-Standing Persistent Atrial Fibrillation https://www.ahajournals.org/doi/full/10.1161/CIRCEP.120.009288 II. Left Bundle Branch Area Pacing - FDA OKs Medtronic Lead for Left Bundle Branch Pacing https://www.medscape.com/viewarticle/982577 - Left bundle branch area pacing outcomes: the multicentre European MELOS study https://academic.oup.com/eurheartj/article/43/40/4161/6671019 - Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy https://www.jacc.org/doi/full/10.1016/j.jacc.2022.07.019 - Early sudden distal conductor fracture of a stylet-driven lead implanted for left bundle branch area pacing https://doi.org/10.1016/j.hrcr.2022.10.004 - Repositioning and extraction of stylet-driven pacing leads with extendable helix used for left bundle branch area pacing https://pubmed.ncbi.nlm.nih.gov/33825263/ - Safety and Procedural Success of Left Atrial Appendage Exclusion With the Lariat Device https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2289126 III. Finerenone - Finerenone Benefits T2D Across Spectrum of Renal Function https://www.medscape.com/viewarticle/982626 - Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes https://www.nejm.org/doi/10.1056/NEJMoa2110956 - Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis https://academic.oup.com/eurheartj/article/43/6/474/6433104 - Finerenone and Heart Failure Outcomes by Kidney Function/Albuminuria in Chronic Kidney Disease and Diabetes https://www.jacc.org/doi/10.1016/j.jchf.2022.07.013 IV. Perceptions of Cardiology - IM Residents Rate Cardiology Low on Work-Life Balance https://www.medscape.com/viewarticle/982578 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Post-PCI antiplatelet therapy, palliative care in patients with HF, Watchman information on hospital websites, and HCM in athletes are the topics John Mandrola, MD, covers in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Post-Stent Antiplatelet Therapy SMART-CHOICE 3-Year Results Support Dropping Aspirin After PCI https://www.medscape.com/viewarticle/981741 Long-term Effects of P2Y12 Inhibitor Monotherapy After Percutaneous Coronary Intervention https://jamanetwork.com/journals/jamacardiology/fullarticle/2796902 The Smart(est) Choice for Dual Antiplatelet Therapy is a Patient-Directed One https://jamanetwork.com/journals/jamacardiology/fullarticle/2796904 Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention https://jamanetwork.com/journals/jama/fullarticle/2736564 II. Palliative Care in HF Home-Based Palliative Care Improves Heart Failure Outcomes https://www.medscape.com/viewarticle/981715 Regional collaborative home-based palliative care and health care outcomes among adults with heart failure https://doi.org/10.1503/cmaj.220784 III. Watchman Info on Hospital Websites Concern Over US Hospital Patient Information on LAA Closure https://www.medscape.com/viewarticle/981961 Analysis of Patient-Focused Information About Left Atrial Appendage Occlusion on US Hospital Web Pages https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2797102 IV. HCM and Exercise in Athletes Athletes With Mild HCM Can Likely Continue Competitive Sports https://www.medscape.com/viewarticle/981782 Impact of Exercise on Outcomes and Phenotypic Expression in Athletes With Nonobstructive Hypertrophic Cardiomyopathy https://www.jacc.org/doi/full/10.1016/j.jacc.2022.08.715 A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM risk-SCD) https://pubmed.ncbi.nlm.nih.gov/24126876/ You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Pulmonary embolism, coffee, when DOACs don't work, lipoprotein (a), and the marginal benefits of current CV therapy are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I. Pulmonary Embolism - Positive Data on Thrombectomy Catheter That Avoids Thrombolytics in Acute PE https://www.medscape.com/viewarticle/981322 - Acute Outcomes for the Full US Cohort of the FLASH Mechanical Thrombectomy Registry in Pulmonary Embolism https://eurointervention.pcronline.com/article/acute-outcomes-for-the-full-us-cohort-of-the-flash-mechanical-thrombectomy-registry-in-pulmonary-embolism - PEERLESS Study https://clinicaltrials.gov/ct2/show/NCT05111613 - Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism (HI-PEITHO) https://clinicaltrials.gov/ct2/show/NCT04790370 - A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism: The FLARE Study https://doi.org/10.1016/j.jcin.2018.12.022 II. Coffee Again - Coffee Linked to Reduced Cardiovascular Disease and Mortality https://www.medscape.com/viewarticle/981518 Enough With the Coffee Research and Other Distractions https://www.medscape.com/viewarticle/883709 - The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank https://doi.org/10.1093/eurjpc/zwac189 III. DOAC and Mechanical Valves - PROACT Xa Trial of Apixaban With On-X Heart Valve Stopped https://www.medscape.com/viewarticle/981644 - Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial https://investors.artivion.com/news-releases/news-release-details/artivion-follows-recommendation-stop-proact-xa-clinical-trial - PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban https://clinicaltrials.gov/ct2/show/NCT04142658 - Dabigatran versus Warfarin in Patients with Mechanical Heart Valves https://www.nejm.org/doi/full/10.1056/nejmoa1300615 IV. Lipoprotein(a) - Aspirin Primary Prevention Benefit in Those With Raised Lp(a)? https://www.medscape.com/viewarticle/981602 - Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes https://www.jacc.org/doi/full/10.1016/j.jacc.2022.07.027 - A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women https://www.nejm.org/doi/full/10.1056/nejmoa050613 - Effect of Aspirin on Disability-free Survival in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1800722 - Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1805819 - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1803955 You may also like: Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact: news@medscape.net