Podcasts about microvascular

Modern joint pain isn't just wear and tear—it's a systemic, metabolic disease that starts years before symptoms show. In this episode, you'll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Kiran Krishnan, a research microbiologist and Chief Scientific Officer at Calroy Health Sciences. He's the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He's a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results. He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You'll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration. You'll learn: • How cartilage cells (chondrocytes) rely on mitochondria for tissue repair • Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog • How cartilage begins to break down in your teens—and what to do about it now • The surprising clinical data on walking distance, inflammation markers, and recovery • Why most supplements and NSAIDs fail—and what actually rebuilds joints • How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal • The mitochondrial link between joint pain, cardiovascular risk, and depression • Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it • How to track your biological joint age using imaging and systemic inflammation labs This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you're lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation **Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave ** Thank you to our sponsors! -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 2:01 — Why Modern Medicine Fails at Joint Pain 3:07 — Painkillers That Accelerate Joint Damage 7:35 — Rheumatoid vs. Osteoarthritis Explained 8:54 — Cytokines That Destroy Cartilage 12:10 — Arthritis Begins in Your Teens 15:35 — 75% Pain Reduction in 7 Days 18:35 — The Science Behind Boswellia & Celery Seed 24:10 — Six-Minute Walk Test Results 25:45 — The $200/Month Painkiller Trap 28:53 — Proof Cartilage Can Regrow 31:01 — Mitochondria and Joint Repair 32:29 — Inflammation Links to Heart Disease 35:52 — Why Glucosamine Doesn't Work 37:07 — Silent Arthritis in 90% of Adults 40:44 — Why Women Face Higher Joint Risk After 40 45:52 — Food as the #1 Inflammation Trigger 47:23 — Fasting & Cartogenics Stack for Repair 50:27 — Movement Snacks and Efficient Training 55:54 — Why Joints Heal Slower Than Muscles 57:48 — Dave's Stack and Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, I sit down with Robert Long and Dr. Hans Vick to uncover the hidden drivers of high blood pressure. Beyond numbers on a blood pressure cuff, we explore how the microvascular system and the Glycocalyx, the intricate network of tiny blood vessels—plays a central role in hypertension and overall cardiovascular health. Together, we discuss cutting-edge insights and natural therapies such as Revasca, that go beyond symptom management to address the root causes, offering hope for sustainable healing and prevention.See omnystudio.com/listener for privacy information.

Hosts Roz and Alberto discuss the key articles of the July issue of the American Journal of Transplantation. [03:48] Liver transplantation for hepatitis D virus/hepatitis B virus coinfection in Italy: an intention-to-treat analysis of long-term outcomes [13:42] 10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury [22:20] Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient [33:35] Microvascular inflammation in kidney allografts: New directions for patient management MOMOT (Mouse Models in Transplant) articles: Can mouse kidney transplant models inform mechanisms of injury and acceptance in clinical kidney transplantation? Best practices in islet transplantation in mice

Can myocardial bridges be more than just incidental findings in cardiac diagnostics? Join us as we unravel this complex topic with Dr. Khaled Ziada from the Cleveland Clinic. You'll gain a deep understanding of how myocardial bridges, often dismissed as non-significant, can impact blood flow, especially when factors like endothelial dysfunction and coronary spasms are involved. Listen in to discover the pivotal role of provocative testing in determining when surgical intervention is truly necessary.We discuss the complex techniques utilized in identifying and evaluating myocardial bridges. From CT scans to angiograms and intravascular ultrasounds, Dr. Ziada walks us through the tools that help pinpoint these bridges with a degree of precision. He also elaborates on the use of dobutamine provocation to assess arterial compression and simulate stress conditions, which can reveal underlying ischemic issues. This comprehensive diagnostic approach is crucial for tailoring surgical and medical treatment strategies to the unique needs of each patient.Finally, we explore the often-underestimated challenges of treating endothelial dysfunction and microvascular disease post-surgery. Dr. Ziada emphasizes the importance of personalized medical therapies and lifestyle interventions in managing these conditions effectively. We also get a glimpse of the exceptional care model at Cleveland Clinic, where patients receive tailored support, whether through virtual or in-person consultations. Collaboration is vital between patients and physicians to enhance quality of life and stability in managing these intricate cardiac conditions and I found Dr. Ziada to have wonderful sense of concern for the well-being of those he works with.You can learn more about the Cleveland clinic HERE.You can email Dr. Ziada directly at ziadaK@ccf.orgChapters(00:00) Myocardial Bridges and Surgery Considerations(06:36) Identification and Evaluation of Myocardial Bridges(16:35) Endothelial Dysfunction and Medical Treatment(28:33) Microvascular Dysfunction and Treatment Options(35:02) Microvascular Dysfunction and Patient Care

Much of cardiovascular disease is linked to the large arteries of the body but we now have ground breaking news for you. Cardiovascular disease starts in the smallest of capillaries in an enormous network called the microvascular system and in a layer of cells called the endocalyx. Robert Long describes his 15 year journey with Dr Hans Vink to discover the endocalyx, the testing and therapies that can eliminate cardiovascular disease. We begin a series on this ground breaking science and your education of this amazing information starts here. See omnystudio.com/listener for privacy information.

In this Leveling Up episode of the PRS Global Open Deep Cuts podcast, Dr. Scott Hansen talks about his new role as Chair of Plastic Surgery at UCSF, his experience as a program director, and his leadership approach to resident training. He also shares insights on performing awake hand surgeries, his role as a team hand surgeon for the San Francisco Giants, and the unique considerations when treating hand injuries in professional athletes. Dr. Hansen explores the surprising differences between college women's basketball and Major League Baseball, how his practice of hand surgery has evolved, the field of spinoplastic surgery, and why he finds treating hidradenitis rewarding. He also reflects on the lessons he's learned from Drs. Steve Mathes, Neil Ford Jones, and Prosper Benhaim. Read a recent PRS Global Open article by Dr. Hansen and his colleagues, “A Pilot Randomized Clinical Trial of Early Ambulation after Groin Reconstruction with Sartorius Muscle Flaps“: https://bit.ly/WalkingAfterGroinRecon  Dr. Scott Hansen is a Professor, Chief of the Division of Plastic Surgery, and the Program Director for the Plastic Surgery Residency at the University of California San Francisco. He also serves as the Chief of Hand and Microvascular surgery and the Director of the Microsurgery fellowship. He graduated from Eastern Virginia Medical School, and then completed a Plastic Surgery residency and a post-doctoral research fellowship at UCSF followed by a Hand and Microvascular surgery fellowship at UCLA. He joined UCSF as full-time faculty, and recently became the Chief of the Division of plastic surgery there. He is the Hand and Microsurgery section editor for the Annals of Plastic Surgery. He is the team hand surgeon for the San Francisco Giants. He has remained involved in basic science research, with a focus in wound healing, hemangiomas, and limb development. Your host, Dr. Puru Nagarkar, is a board-certified plastic and hand surgeon, and Associate Professor of Plastic Surgery at the University of Texas Southwestern Medical Center in Dallas. #PRSGlobalOpen #DeepCutsPodcast #PlasticSurgery #LevelingUp

The FiltrateJoel TopfSwapnil HiremathAC GomezSopia AmbrusoNayan AroraSpecial Guests Michelle Rheault, Director, Division of Pediatric Nephrology, Professor of MedicineTiffany Caza, Nephropathologist, Scientist and self-described Freely Filtered fan girlEditing bySimon Topf and Sophia AmbrusoShow Notes10. Healthcare Cyberattacks9. ApoE in C3 glomerulonephropathy8. Workforce woes in Adult and Pediatric Nephrology7. Hyponatremia correction meta-analysis6. Microvascular inflammation increases risk of graft loss - in all of its forms5. Xenotransplantation4. KDIGO CKD Guidelines3. Hypertension control trials (ESPRIT, BPROAD)2. The Renaissance of IgAN: IgAN treatment trials1. FLOW: GLP-1 RAs in CKD

Prof Alisa Clyne and Dr Callie Weber from the University of Maryland speak to Dr Gita Thapaliya about an eBioMedicine article examining the impacts of APOE-ε4 and exercise training on brain function and metabolism.Read the full article:https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00523-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_ebiomContinue this conversation on social!Follow us today at...https://twitter.com/thelancethttps://instagram.com/thelancetgrouphttps://facebook.com/thelancetmedicaljournalhttps://linkedIn.com/company/the-lancethttps://youtube.com/thelancettv

Mirza Umair Khalid, MD, social media editor of JACC: Cardiovascular Interventions, and Amir Lerman, MD, discuss the phase II study examining coronary sinus reducer for treatment of microvascular dysfunction.

Microvascular disease is a silent but deadly condition that could be damaging your heart, brain, kidneys, and liver—without you even knowing it. In this episode of Everyday Health Stories, Dr. Kota Reddy uncovers how this overlooked disease quietly affects millions, often going undetected until serious complications arise. Learn how coronary microvascular dysfunction (CMD) impacts the heart, leading to heart failure with preserved ejection fraction (HFpEF), and discover the everyday habits that may be fueling vascular damage. Most importantly, find out simple, science-backed steps to protect your vital organs and fight back against this hidden threat before it's too late!

$5 Q-BANK: https://patreon.com/highyieldfamilymedicine Intro 0:30, Diagnostic criteria 2:02, Type 1 vs type 2 diabetes 5:43, Metformin 6:57, Sulfonylureas 8:36, TZDs 9:09, DPP-4 inhibitors 9:54, GLP-1 agonists 10:39, SGLT2 inhibitors 12:39, Insulin 14:08, Diabetic ketoacidosis (DKA) 16:32, Hyperglycemic hyperosmolar syndrome (HHS) 23:07, Microvascular complications 25:06, Macrovascular complications 33:07, Practice questions 34:46

Microvascular dysfunction is a heart disease affecting the walls and inner lining of tiny coronary artery blood vessels that branch off from the larger coronary arteries. Younger women are at a higher risk of developing this disease, and the Women's Heart Center at MemorialCare Long Beach Medical Center want to ensure women understand the signs and symptoms of the disease early.

Audio Commentary by Dr. Valentin Fuster, Emeritus Editor in Chief

Dr. Sara Vasconcelos is a Senior Scientist and the John Kitson McIvor Endowed Chair in Diabetes Research at University Health Network. She is also an Associate Professor at the Institute of Biomedical Engineering at the University of Toronto. Her lab studies microvascular regeneration in cardiovascular diseases and diabetes, and are working to develop personalized patient-derived organ-chip models for drug screening and other applications. In this episode, she talks about modeling cardiac fibrosis and studying pancreatic islet vasculature. She also discusses working with microchips and with large animal models.

Commentary by Dr. Valentin Fuster

Commentary by Dr. Abdullah Al-Abcha and Dr. John Blair

Commentary by Dr. Valentin Fuster

On this week's listener series episode, we welcome Valerie. Valerie shares her journey with pregnancy and birth as a Type 1 Diabetic. Everything went smoothly until 2 days after discharge, when Valerie started to feel unwell. She shares how her family navigated a hospital stay postpartum and her second homecoming. What you will hear on this episode:- Pregnancy with Type 1 Diabetes- Preeclampsia diagnosis at 32 weeks- Induction and vacuum birth- Postpartum readmission- Microvascular angina- Postpartum while recovering from complicationsIf you have a birth trauma story you would like to share with us, click this link and fill out the form. For more birth trauma content and a community full of love and support, head to my Instagram at @birthtrauma_mama.Learn more about the support and services I offer through The Birth Trauma Mama Therapy & Support Services.

Many women who have typical symptoms of coronary artery disease actually have coronary microvascular disease (MVD). Gretchen Wells, M.D., a cardiologist, explains why it is important for physicians to proceed with tests for MVD when cardiac catheterization does not indicate coronary artery disease. She explores the common symptoms, proven and potential interventions, and the serious risks posed by MVD. Dr. Wells recommends patients explore multidisciplinary cardiac rehabilitation programs if they are diagnosed with MVD.

Commentary by Dr. Valentin Fuster

Editor in Chief Cecelia E. Schmalbach, MD, MSc, is joined by Associate Editor Babak Givi, MD, and lead author Leila J. Mady MD, PhD, MPH, to discuss “Gender Differences Among Head and Neck Microvascular Reconstructive Surgeons,” which published in the November 2023 issue of Otolaryngology–Head and Neck Surgery.  The research used a survey that was sent to facial plastic and maxillofacial surgeons, in addition to microvascular surgeons, to gain a comprehensive understanding of what causes gender differences in the subspecialty. One takeaway of note was that there were no gender differences when it came to training and practice patterns. Another revealed gender differences when explaining changes in practice—for men, the reasons related to career advancement; for women, the reasons related to burnout, usually related to work-life balance and especially if they have children.

In this weeks episode, we'll learn more about the role of IL-7 receptor signaling in the differentiation and expansion of human B-cell progenitors, discuss the use of fixed-duration venetoclax plus obinutuzumab in older patients with chronic lymphocytic leukemia, and learn how low-density lipoprotein promotes microvascular thrombosis by enhancing von Willebrand Factor self-association 

Tigist Wodaje, Kardiolog, Doktorand, KS, KI berättar om att asymptomatiska patienter inte är evaluerade med bilddiagnostik ganska ofta pga. risker associerade med bilddiagnostiken. PP-ELI-SWE-2812

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, “Microvascular contributions to white matter injury in Alzheimer's disease.” In their new editorial, researchers Zsolt Bagi, Larry S. Sherman and Stephen A. Back from Augusta University discuss mechanisms of cognitive impairment and dementia. Impairments in cognitive and executive function of presumed cerebral microvascular origin are important and recently recognized neuropathological manifestations of vascular contributions to cognitive impairment and dementia (VCID). It has been long known that hypertensive cerebrovascular disease also involves a spectrum of subcortical small vessel diseases, such as arteriolosclerosis and lipohyalinosis of small penetrating arterioles, which contribute to progressive injury of periventricular, frontal and parietal white matter (WM). “However, until recently, recognition of the role of WM injury during aging and the progression of Alzheimer disease and related dementias (AD/ADRD) was very limited.” Despite growing interest in VCID and AD/ADRD, there have been few studies of mechanistic links between subcortical small vessel disease, WM injury and cognitive decline. Even though WM constitutes >80% of the human cerebral hemispheres, a PubMed search of AD and WM injury yielded only 381 articles (including reviews) vs. 193,303 articles for AD alone. Notably, 50% of diagnosed AD patients have mixed vascular and AD pathology. Hence, there is a critical need to explore connections between AD, WM injury and cerebral small vessel disease to define mechanisms and diagnostic features of mixed vascular and AD neuropathological change (ADNC). “To provide rigorous access to human WM lesions, we recently developed a unique rapid autopsy brain procurement protocol using specimens donated by participants in the Adult Changes in Thought (ACT) study, a prospective, population-based study of aging and incident dementia among men and women in Seattle, Washington [5].” DOI - https://doi.org/10.18632/aging.204997 Corresponding author - Zsolt Bagi - zbagi@augusta.edu Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204997 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cerebrovascular, neuropathology, vasodilation, parenchymal, arteriole About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com​​ and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ Twitter - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Dr Alessandro Cicchetti and Luca Possenti present the results of the AIRC project “Mechanistic computational modelling of radiation damage to microvasculature and of its effect on tumour microenvironment”. This research comprises pre-clinical microfluidic chips, in-silico models, and patient data. The interview by Dr Orazio Fortunato gives an overview of the methodology and the possible impact on clinical practice.

Nanoparticles are manmade fibers, particulates, and other objects that are so small that when inhaled, they can escape the lungs and enter other body systems. Timothy Nurkiewicz, West Virginia University, studies the effects of these and other particulars. He discusses his inhalation and nanotoxicology research, as well as work with the National Guard on developing facemasks to protect against airborne diseases, with co-hosts Anne Chappelle and David Faulkner.About the GuestTimothy R. Nurkiewicz, PhD, is the E.J. Van Liere Medicine Professor and Chair of the Department of Physiology and Pharmacology at the West Virginia University (WVU) School of Medicine. He is also the Director of the WVU Inhalation Facilities and Center for Inhalation Toxicology (iTOX) and has been a guest researcher with the National Institute for Occupational Safety and Health since 2008.Dr. Nurkiewicz's research is in the fields of microvascular physiology and toxicology, with specific focus on pulmonary exposure to particulate matter and engineered nanomaterials. His research program pioneered novel investigations in the field of maternal nanomaterial exposures and fetal microvascular ramifications. Through iTOX, his lab and team are able to replicate the atmospheres that humans are exposed to in order to advance understanding of their acute and chronic toxicities.Dr. Nurkiewicz earned a BS in exercise and sport science from Pennsylvania State University, a MS in exercise physiology from WVU, and a PhD in physiology from WVU. He completed postdocs at Texas A&M University and WVU. Currently, Dr. Nurkiewicz serves as an Associate Editor for Frontiers—Vascular Physiology and Particle and Fibre Toxicology and is a founding member and Past President of the SOT Cardiovascular Toxicology Specialty Section.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.06.29.547081v1?rss=1 Authors: Mihelic, S. A., Engelmann, S. A., Sadr, M. S., Jafari, C. Z., Zhou, A., Williamson, M. R., Dunn, A. K. Abstract: This research article quantitatively investigates neuro-microvascular network remodeling dynamics following stroke using a novel in vivo two-photon angiography (cubic millimeter volume, weekly snapshots) and high throughput (thousands of connected capillaries) vascular vectorization method. The results suggest distinct temporal patterns of cerebrovascular plasticity, with acute remodeling peaking at one week post-stroke. The network architecture then gradually stabilizes, returning to a new steady state after four weeks. These findings align with previous literature on neuronal plasticity, highlighting the correlation between neuronal and neurovascular remodeling. Quantitative analysis of neurovascular networks using length- and strand-based statistical measures reveals intricate changes in network anatomy and topology. The distance and strand-length statistics show significant alterations, with a peak of plasticity observed at one week post-stroke, followed by a gradual return to baseline. The orientation statistic plasticity peaks at two weeks, gradually approaching the (conserved across subjects) stroke signature. The underlying mechanism of the vascular response (angiogenesis vs. tissue deformation), however, is yet unelucidated, requiring network registration advancements. Overall, the combination of two-photon angiography, vectorization, reconstruction/visualization, and statistical analysis enables both qualitative and quantitative assessments of neurovascular remodeling dynamics, demonstrating an impactful method for investigating neuro-microvascular network disorders and the therapeutic modes of action thereof. Understanding the timing and nature of neurovascular remodeling allows for optimized interventions, including personalized medicine for stroke rehabilitation. Additionally, the evaluation of pharmaceutical interventions using these tools may facilitate targeted drug development. Furthermore, neurovascular coupling dynamics have implications for neurodegenerative diseases, brain aging, and the field of brain-computer interfaces. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

ESC TV Today brings you concise analysis from the world's leading experts, so you can stay on top of what's happening in your field quickly. This episode covers: Cardiology This Week: A concise summary of recent studies Microvascular angina Minimally invasive tricuspid valve surgery Mythbusters: An apple a day keeps the doctor away Host: Rick Grobbee Guests: Volkmar Falk and Eva Prescott Want to watch that episode? Go to: https://esc365.escardio.org/event/1095   Disclaimer This programme is supported by Siemens Healthineers in the form of an educational grant. The scientific content and opinions expressed in the programme have not been influenced in any way by its sponsor. This programme is supported by Siemens Healthineers in the form of an educational grant. The scientific content and opinions expressed in the programme have not been influenced in any way by its sponsor. This programme is intended for health care professionals only and is to be used for educational purposes. The European Society of Cardiology (ESC) does not aim to promote medicinal products nor devices. Any views or opinions expressed are the presenters' own and do not reflect the views of the ESC.   Declarations of interests Stephan Achenbach, Rick Grobbee, Nicolle Kraenkel and Eva Prescott have declared to have no potential conflicts of interest to report. Carlos Aguiar has declared to have potential conflicts of interest to report: personal fees for consultancy and/or speaker fees from Abbott, Alnylam, Amgen, AstraZeneca, Bayer, Boehringer-Ingelheim, Daiichi-Sankyo, Ferrer, Gilead, Lilly, Novartis, Pfizer, Sanofi, Servier, Tecnimede. Davide Capodanno has declared to have potential conflicts of interest to report: Sanofi, Daiichi Sankyo, Terumo, Medtronic, Chiesi. Volkmar Falk has declared to have potential conflicts of interest to report: Medtronic GmbH, Biotronik SE & Co., Abbott GmbH & Co. KG, Boston Scientific, Edwards Lifesciences, LivaNova, Berlin Heart, Novartis Pharma GmbH, JOTEC GmbH, Zurich Heart.  Emma Svennberg has declared to have potential conflicts of interest to report: institutional research grants from Bayer, Bristol-Myers, Squibb-Pfizer, Boehringer- Ingelheim, Johnson & Johnson, Merck Sharp & Dohme.

Dr Sanjeev Goel interviews world renowned expert Dr Hans Vink on the science of the Glycocalyx and Robert Long from Microvascular Health Solutions.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.16.537063v1?rss=1 Authors: Caratis, F., Karaszewski, B., Klejbor, I., Furihata, T., Rutkowska, A. Abstract: The EBI2 receptor is a major modulator of innate immunity and, together with its ligand, oxysterol 7,25OHC, has been implicated in several neuroinflammatory and autoimmune diseases. 7alpha,25OHC is synthesised from cholesterol with CH25H and CYP7B1 enzymes and degraded with HSD3B7. The concentration of 7alpha,25OHC in the brain increases in the early phases of the murine model of multiple sclerosis, leading to an enhanced central nervous system (CNS) infiltration with EBI2-expressing lymphocytes. Here, we aimed to investigate whether the enzymes involved in the synthesis and degradation of 7alpha,25OHC are expressed directly in the mouse brain microvascular cells and whether systemic inflammation modulates their levels in these cells. Normal mouse brain capillaries were isolated and immunostained for EBI2, CH25H, CYP7B1 and HSD3B7. Subsequently, mice were challenged with lipopolysaccharide and the mRNA expression in whole brain homogenates was measured. Changes in the receptor and enzyme levels were quantified directly in endothelial cells (ECs), pericytes and astrocytes. The data indicated high levels of EBI2 in the brain microvascular ECs, pericytes and astrocytes with the highest co-localisation in pericytes. CH25H was detected in ECs and astrocytes with low levels in pericytes. CYP7B1 was moderately expressed in ECs, astrocytes and pericytes. The 7alpha,25OHC degrading enzyme HSD3B7 was the least detected in astrocytes. Moreover, the data indicated that systemic inflammation downregulated the mRNA levels of Ebi2 and upregulated Ch25h expression in the whole brain. Specifically in each cell type, EBI2 was not induced in ECs but increased in astrocytes and pericytes. CH25H levels increased in astrocytes and pericytes and CYP7B1 in ECs and astrocytes. The degrading enzyme, HSD3B7, was least affected by systemic inflammation. Taken together, we here demonstrate that EBI2 and the enzymes regulating its ligand levels are differentially expressed in mouse brain microvessels and are highly modulated by systemic inflammation. Upregulated concentration of 7alpha,25OHC in the brain during inflammation may lead to an increased migration of EBI2-expressing immune cells into the CNS during infection or neuroinflammatory disease. Modulation of the EBI2/oxysterol system in the brain or directly in the brain blood vessels may thus provide a new approach to treating neuroinflammatory diseases including multiple sclerosis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Commentary by Dr. Candice Silversides

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.03.535441v1?rss=1 Authors: Bei, J., Miranda-Morales, E. G., Gan, Q., Qiu, Y., Husseinzadeh, S., Liew, J. Y., Chang, Q., Krishnan, B., Gaitas, A., Yuan, S., Felicella, M., Qiu, W., Fang, X., Gong, B. Abstract: Background: Blood-brain barrier (BBB) breakdown is a component of the progression and pathology of Alzheimer's disease (AD). BBB dysfunction is primarily caused by reduced or disorganized tight junction or adherens junction proteins of brain microvascular endothelial cell (BMEC). While there is growing evidence of tight junction disruption in BMECs in AD, the functional role of adherens junctions during BBB dysfunction in AD remains unknown. Exosomes secreted from senescent cells have unique characteristics and contribute to modulating the phenotype of recipient cells. However, it remains unknown if and how these exosomes cause BMEC dysfunction in AD. Objectives: This study aimed to investigate the potential roles of AD circulating exosomes and their RNA cargos in brain endothelial dysfunction in AD. Methods: We isolated exosomes from sera of five cases of AD compared with age- and sex-matched cognitively normal controls using size-exclusion chromatography technology. We validated the qualities and particle sizes of isolated exosomes with nanoparticle tracking analysis and atomic force microscopy. We measured the biomechanical natures of the endothelial barrier of BMECs, the lateral binding forces between live BMECs, using fluidic force miscopy. We visualized the paracellular expressions of the key adherens junction protein VE-cadherin in BMEC cultures and a 3D BBB model that employs primary human BMECs and pericytes with immunostaining and evaluated them using confocal microscopy. We also examined the VE-cadherin signal in brain tissues from five cases of AD and five age- and sex-matched cognitively normal controls. Results: We found that circulating exosomes from AD patients suppress the paracellular expression levels of VE-cadherin and impair the barrier function of recipient BMECs. Immunostaining analysis showed that AD circulating exosomes damage VE-cadherin integrity in a 3D model of microvascular tubule formation. We found that circulating exosomes in AD weaken the BBB depending on the RNA cargos. In parallel, we observed that microvascular VE-cadherin expression is diminished in AD brains compared to normal controls. Conclusion: Using in vitro and ex vivo models, our study illustrates that circulating exosomes from AD patients play a significant role in mediating the damage effect on adhesions junction of recipient BMEC of the BBB in an exosomal RNA-dependent manner. This suggests a novel mechanism of peripheral senescent exosomes for AD risk. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-12259.mp3?cb=1678922888.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Microstructural and Microvascular Alterations in Psychotic Spectrum Disorders: A Three-Compartment Intravoxel Incoherent Imaging and Free Water Model – Faye McKenna et al.Full EntryMicrostructural and Microvascular Alterations in Psychotic Spectrum Disorders: A Three-Compartment Intravoxel Incoherent Imaging and Free Water Model –

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.12.532316v1?rss=1 Authors: Ullah, K., Ai, L., Li, Y., Liu, L., Zhang, Q., Pan, K., Humayun, Z., Sitikov, A., Su, Q., Zhao, Q., Sharp, W. W., Fang, Y., Wu, D., Liao, J. K., Wu, R. Abstract: Rationale: Cardiac microvascular leakage and inflammation are triggered during myocardial infarction (MI) and contribute to heart failure. Hypoxia-inducible factor 2 (Hif2) is highly expressed in endothelial cells (ECs) and rapidly activated by myocardial ischemia, but whether it has a role in endothelial barrier function during MI is unclear. Objective: To test our hypothesis that the expression of Hif2 and its binding partner aryl hydrocarbon nuclear translocator (ARNT) in ECs regulate cardiac microvascular permeability in infarcted hearts. Methods and Results: Experiments were conducted with mice carrying an inducible EC-specific Hif2-knockout (ecHif2-/-) mutation, with mouse cardiac microvascular endothelial cells (CMVECs) isolated from the hearts of ecHif2-/- mice after the mutation was induced, and with human CMVECs and umbilical-vein endothelial cells transfected with ecHif2 siRNA. After MI induction, echocardiographic assessments of cardiac function were significantly lower, while measures of cardiac microvascular leakage (Evans blue assay), plasma IL6 levels, and cardiac neutrophil accumulation and fibrosis (histology) were significantly greater, in ecHif2-/- mice than in control mice, and RNA-sequencing analysis of heart tissues from both groups indicated that the expression of genes involved in vascular permeability and collagen synthesis was enriched in ecHif2-/- hearts. In cultured ECs, ecHif2 deficiency was associated with declines in endothelial barrier function (electrical cell impedance assay) and the reduced abundance of tight-junction proteins, as well as an increase in the expression of inflammatory markers, all of which were largely reversed by the overexpression of ARNT. We also found that ARNT, but not Hif2, binds directly to the IL6 promoter and suppresses IL6 expression. Conclusions: EC-specific deficiencies in Hif2 expression significantly increase cardiac microvascular permeability, promote inflammation, and reduce cardiac function in infarcted mouse hearts, and ARNT overexpression can reverse the upregulation of inflammatory genes and restore endothelial-barrier function in Hif2-deficient ECs. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.09.527854v1?rss=1 Authors: Kaur, G., Pant, P., Bhagat, R., Seth, P. Abstract: Neurotropic viruses can cross the otherwise dynamically regulated blood-brain barrier (BBB) and affect the brain cells. Zika virus (ZIKV) is an enveloped neurotropic Flavivirus known to cause severe neurological complications, such as encephalitis and foetal microcephaly. In the present study, we used human brain microvascular endothelial cells (hBMECs) and human progenitor derived astrocytes to form a physiologically relevant BBB model. We used this model to investigate the effects of ZIKV envelope (E) protein on properties of cells comprising the BBB. E protein is the principal viral protein involved in interaction with host cell surface receptors, facilitating the viral entry. Our findings show that ZIKV E protein results in activation of both hBMECs and astrocytes. hBMECs showed reduced expression of endothelial junction proteins - ZO-1, Occludin and VE-Cadherin, which are crucial in establishing and maintaining the BBB. As a result, ZIKV E protein triggered alteration in BBB integrity and permeability. We also found upregulation of genes involved in leukocyte recruitment along with increased proinflammatory chemokines and cytokines upon exposure to E protein. Furthermore, E protein resulted in astrogliosis as seen by increased expression of GFAP and Vimentin. Both BBB cell types exhibited inflammatory response following exposure to E protein which may influence viral access into the central nervous system (CNS), resulting in infection of other CNS cells. Overall, our study provides valuable insights into the transient changes that occur at the site of BBB upon ZIKV infection. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.23.525218v1?rss=1 Authors: Chen, C., Qin, Y., Xu, Y., Chen, L., Wang, L., Liu, D. Abstract: In patients with diabetic microvascular complications, reduced vessel perfusion or vascular occlusion is a common characteristic which will cause the insufficient blood supply. However, identification of novel regulators involved in microvascular lumenization defects is hindered by the lacking of a model for imaging the blood vessels at high resolution in vivo. Taking advantage of the transparency of zebrafish, we observed the reduction of vascular diameter and compromised perfusion in high glucose treated embryos. RNA sequencing and whole-mount in situ hybridization analysis indicated that two aquaporins (aqp1a.1 and aqp8a.1) were significant down-regulated, which was further confirmed by endothelial specific Q-PCR. It was also shown that the two aqps were spatio-temporally enriched in the endothelial cells (ECs) of vascular system. Zebrafish with loss of aqp1a.1 or aqp8a.1 displayed lumenization defects in intersegmental vessels, recapitulating the phenotype in hyperglycemic zebrafish model. While overexpressing the aquaporins in zebrafish promoted the enlargement of the vascular diameter. Moreover, the defective vasculature induced by high-glucose treatment could be rescued by aqp1a.1 upregulation. In addition, both aqp1a.1 and apq8a.1 were localized in the intracellular vacuoles in cultured ECs as well as in the ECs of sprouting ISVs, and loss of Aqps caused the reduction of those vacuoles, which was required for lumenization. Finally, we found that the expression of human AQP1 was downregulated in diabetic human retina samples and high-glucose treated human retinal microvascular endothelial cells. All these results suggest that EC-enriched aquaporins have a role in developmental and pathological blood vessel lumenization, and they might be potential targets for gene therapy to cure diabetes-related vascular lumenization defects. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underlie ischemic events and the need for appropriate animal models for optimal translation.

Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underlie ischemic events and the need for appropriate animal models for optimal translation.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.23.517628v1?rss=1 Authors: Zhang, Q., Yang, Y., Cao, K. J., Chen, W., Paidi, S., Xia, C.-h., Kramer, R., Gong, X., Ji, N. Abstract: The retina, behind the transparent optics of the eye, is the only neural tissue whose physiology and pathology can be non-invasively probed by optical microscopy. The aberrations intrinsic to the mouse eye, however, prevent high-resolution investigation of retinal structure and function in vivo. Optimizing the design of a two-photon fluorescence microscope (2PFM) and sample preparation procedure, we found that adaptive optics (AO), by measuring and correcting ocular aberrations, is essential for resolving synapses and achieving three-dimensional cellular resolution in the mouse retina in vivo. Applying AO-2PFM to longitudinal retinal imaging in transgenic models of retinal pathology, we characterized microvascular lesions and observed microglial migration in a proliferative vascular retinopathy model, and found Lidocaine to effectively suppress retinal ganglion cell hyperactivity in a retinal degeneration model. Tracking structural and functional changes at high resolution longitudinally, AO-2PFM enables microscopic investigations of retinal pathology and pharmacology for disease diagnosis and treatment in vivo. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

In this episode of the Award-winning PRS Journal Club Podcast, 2022 Resident Ambassadors to the PRS Editorial Board – Saïd Azoury, Emily Long, and Ronnie Shammas- and special guest Brett T. Phillips, MD, discuss the following articles from the November 2022 issue: “Risk Factors for Partial Flap Loss in a Free Flap: A 12-Year Retrospective Study of Anterolateral Thigh Free Flaps in 303 Lower Extremity Cases” by Min, Hong, and Suh. Read the article for FREE: https://bit.ly/PerforatorFlapLoss Special guest Brett T. Philips, MD, is an Assistant Professor and Program Director at Duke Integrated Plastic Surgery Program. He completed his General Surgery training at the State University Of New York At Stony Brook, Plastic Surgery training at Duke University, and Microvascular training at MD Anderson. He is the new Chair of the Young Microsurgeons Group Committee. READ the articles discussed in this podcast as well as free related content from the archives: https://bit.ly/PRSNov22Collection

In this episode of the Award-winning PRS Journal Club Podcast, 2022 Resident Ambassadors to the PRS Editorial Board – Saïd Azoury, Emily Long, and Ronnie Shammas- and special guest Brett T. Phillips, MD, discuss the following articles from the November 2022 issue: “Clinical Relevance of Sensory Nerve Coaptation in DIEP Flap Breast Reconstruction Evaluated Using the BREAST-Q” by Bijkerk, Buegels, van Kujik et al. Read the article for FREE: https://bit.ly/NerveCoapatationDIEP Special guest Brett T. Philips, MD, is an Assistant Professor and Program Director at Duke Integrated Plastic Surgery Program. He completed his General Surgery training at the State University Of New York At Stony Brook, Plastic Surgery training at Duke University, and Microvascular training at MD Anderson. He is the new Chair of the Young Microsurgeons Group Committee. READ the articles discussed in this podcast as well as free related content from the archives: https://bit.ly/PRSNov22Collection

In this episode of the Award-winning PRS Journal Club Podcast, 2022 Resident Ambassadors to the PRS Editorial Board – Saïd Azoury, Emily Long, and Ronnie Shammas- and special guest Brett T. Phillips, MD, discuss the following articles from the November 2022 issue: “Large-Volume Fat Grafting: Identifying Risk Factors for Fat Necrosis” by Chang, Lanni, Mirzabeigi, and Bucky. Read the article for FREE: https://bit.ly/LargeVolFatGrafting Special guest Brett T. Philips, MD, is an Assistant Professor and Program Director at Duke Integrated Plastic Surgery Program. He completed his General Surgery training at the State University Of New York At Stony Brook, Plastic Surgery training at Duke University, and Microvascular training at MD Anderson. He is the new Chair of the Young Microsurgeons Group Committee. READ the articles discussed in this podcast as well as free related content from the archives: https://bit.ly/PRSNov22Collection

Enduring CME will expire on 11/2/2024. The presentation is originating from Northeast Georgia Medical Center Gainesville. Objectives: 1. To review sex differences in ischemic heart disease prevalence and outcomes 2. To understand new data regarding sex-specific ischemic heart disease pathophysiology in women 3. To evaluate sex-specific diagnosis and treatment strategies for ischemic heart disease in women Disclosures: Grant support*: NHLBI, Louis B Mayer Foundation, NIH-CTSI, CMDRP-DoD, NIH-Caladrius, California Institute for Precision Medicine (CIAPM), Sanofi-Vascular Consulting: Medscape*, Sanofi-Vascular*, NIH CSR and NIH ORWHAB*, iRhythm Honorarium*: Abbott Diagnostics Stocks: None Accreditation and Designation: The Northeast Georgia Medical Center & Health System, Inc. is accredited by the Medical Association of Georgia to provide continuing medical education for physicians. The Northeast Georgia Medical Center & Health System, Inc. designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s) TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

The GRADE studies evaluated the pharmacotherapy of diabetes after initiation of metformin – for both micro- and macrovascular outcomes. Join host, Geoff Wall, and guest Jake Galdo as they examine these studies to determine if they are GameChangers in diabetes management.The GameChangerInsulin glargine and liraglutide had the biggest decrease in A1c; however, many patients still did not reach goal targets. Minor differences in microvascular and macrovascular outcomes were observed.Show Segments00:00 - Introductions1:40 - The GRADE Studies12:02 - Glycemic Outcomes16:08 - Microvascular and Cardiovascular Outcomes21:10 - The GameChanger: Selecting a Second Medication27:18 - Connecting to Practice: Realistic Diabetes Care33:17 - Closing RemarksHostGeoff Wall, PharmD, BCPS, FCCP, CGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint HealthGuestJohn A Galdo, PharmD, MBA, BCPS, BCGP (Jake)Director, CEimpactPharmacist, Ross Bridge PharmacyCEO, SeguridadReferences and ResourcesGlycemia Reduction in Type 2 Diabetes - Glycemic OutcomesGlycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Redeem your CPE or CME hereCPE (Pharmacist)CME (Physician)Get a membership & earn CE for GameChangers Podcast episodes (30 mins/episode)Pharmacists: Get a membershipPrescribers: Get a membershipCE InformationLearning ObjectivesUpon successful completion of this knowledge-based activity, participants should be able to:1. Select a second medication after metformin in a patient with type 2 diabetes based on the data from the GRADE studies2. Discuss the results of the GRADE studies0.05 CEU/0.5 HrUAN: 0107-0000-22-401-H01-PInitial release date: 10/31/2022Expiration date: 10/31/2023Additional CPE and CME details can be found here.Follow CEimpact on Social Media:LinkedInInstagramDownload the CEimpact App for Free Continuing Education + so much more!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.24.505172v1?rss=1 Authors: Uruk, G., Ozcan, S. Y., Aktas, C. C., Taskiran-Sag, A., Donmez-Demir, B., Duran, J., Guinovart, J. J., Karatas-Kursun, H., Dalkara, T., Ozkan, M. Y. Abstract: Ischemic stroke results in sudden blood flow cessation, thus, unmet energy requirements. Although the clotted artery can be recanalized and blood flow is restored, brain perfusion may not be fully attained due to microvascular constrictions. Under glucose-deprived and hypoxic conditions, glucose derived from the glycogen stored around peri-microvascular astrocyte end-feet may serve as an emergency fuel to meet the metabolic demand during the acute period of ischemic stroke. To elucidate the impact of glycogen utilization on brain microcirculation, we administered glycogen phosphorylase inhibitor 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) intracerebroventricularly. Transgenic mice in which glycogen synthase-1 expression was selectively knocked out in central nervous system (GYS1Nestin-KO) were also used. Both approaches caused microvascular constrictions mediated by CD13-positive pericyte contractions. When mice with disrupted glycogen utilization were subjected to MCA ischemia, pericyte-mediated microvascular constrictions and the infarct volumes were further increased compared to untreated controls or wild-type littermates. Peri-microvascular glycogen depletions were highly correlated with microvascular constrictions as shown by Periodic acid Schiff (PAS) staining and immunolabeling with anti-glycogen antibodies. Imaging of regional cortical blood flow changes during ischemia disclosed severely compromised blood flow dynamics in mice with disrupted glycogen metabolism. In conclusion, disrupting glycogen utilization causes ischemic-like microvascular constrictions under non-ischemic circumstances and increases susceptibility to brain ischemia. Understanding the role of glycogen at neurogliovascular level in brain may provide novel insight to the pathophysiology of ischemic stroke and therapeutic opportunities. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

The Journal RETINA is devoted exclusively to diseases of the retina and vitreous. These podcasts are intended to bring to its listeners summaries of selected articles published in the current issue of this internationally acclaimed journal.

This episode features Dr. Ofer Azoulay. He serves as  Assistant Professor and Chief of Robotic and Microvascular Head and Neck Reconstruction at SUNY Downstate Health Sciences University. Be sure to check out the Downstate ENT Patient Stories we discuss in this week's episode: Matthew Racies: https://www.youtube.com/watch?v=dwYra708wF4&ab_channel=DownstateTV John Rodriguez: https://www.youtube.com/watch?v=aV3BLG_eZOw&ab_channel=DownstateTV Natalia Plaza: https://www.youtube.com/watch?v=Os5zRSVRQW0&ab_channel=DownstateTV Mary Williams: https://www.youtube.com/watch?v=8q_FYXrdCSQ&ab_channel=DownstateTV 

In this episode, Associate Editor Amanda LeBlanc (University of Louisville) interviews authors Lacy Alexander and Gabrielle Dillon (The Pennsylvania State University) along with content expert Melissa Witman (University of Delaware) about a new study by Dillon et al. With their lab closed due to the pandemic, the Alexander Lab continued to hold journal club meetings virtually to discuss two articles published previously in AJP-Heart and Circ – Ratchford et al. and Nandadeva et al. The intriguing results in these studies became a catalyst for new research questions which the Alexander Lab began to pursue as soon as they could return to human research post-pandemic. In contrast to both Ratchford et al. and Nandadeva et al., Dillon et al. found that healthy young adults who had recovered from mild to moderate COVID-19 did not display alternations in nitric oxide-mediated cutaneous microvascular. The authors hypothesized that methodology, onset of symptomology, and the role of vaccine-generated antibodies are key reasons their results differed from other recent studies. In addition, the authors found that having vaccine-generated antibodies was not detrimental to the microvasculature. The authors navigated numerous roadblocks in undertaking this study—stringent COVID-19 health and safety measures, scarce PPE, difficulty enrolling participants, and required COVID-19 testing protocols prior to participation. When faced with the decision on how to handle enrolling fully vaccinated, partially vaccinated and unvaccinated subjects, the authors opted to include all and stratify their results. This is an episode as much about resilience as it is about research. In search of inspiration for how to pivot and keep moving forward? Listen now.   Gabrielle A. Dillon, S. Tony Wolf, and Lacy M. Alexander Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection   Am J Physiol Heart Circ Physiol, published January 28, 2022. DOI: doi.org/10.1152/ajpheart.00602.2021

The post Episode 044: Microvascular Health appeared first on Rehab U Practice Solutions.

The University of Texas MD Anderson Cancer Center's Microvascular Reconstruction Surgery is designed to provide advanced postgraduate training for plastic surgeons in microvascular reconstructive surgery for oncology patients. In this episode, two fellows, Jessie Z. Yu, M.D., and Stefanos Boukovalas, M.D., share their experiences.