Podcasts about Prednisone

You asked, I answered!In today's episode I'm answering your questions about eczema healing, medications, TSW, gut health, nervous system, travel, my own healing journey, and more.Make sure you subscribe for weekly episodes and leave a review if you enjoyed this one :) Work with Julia:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book a Free Consultation⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book a 1:1 EFT Tapping Session with Julia⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Follow Julia on her social⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠@juliachien.rd⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠!

What happens when a doctor warns that prednisone might give you too much energy, and you have been tired for 30 years?Sandy tees up JB's unexpected laugh after a root canal redo lands him on oral steroids. The crew digs into cold plunges, falling asleep mid-root-canal, offering to sit next to screaming babies on planes, and the freak-out of friends who are already grandparents.If you love The JB and Sandy Show, subscribe, leave a review, and share this episode.

What do you do when the doctor warns that prednisone might give you too much energy?JB laughs in the oral surgeon's face after a root canal redo, then reports back with zero amp and a nap impulse instead. He fell asleep mid-procedure, welcomes screaming babies on planes, and the crew spirals into grandpa age freak-outs with buddy Brock already twice a granddad.If you love The JB and Sandy Show, subscribe, leave a review, and share this one with a friend.

What happens when prednisone, weekend car washes, and Big Bertha all show up before 10 a.m.?The complete podcast-clean edition of The JB and Sandy Show. Sandy, JB, and Tricia hit a wild week with Marlon, Sheridan land talk, Dolly and Burt, Care Don't Care, jet-ski scooters, Linda's Minute to Win It, sister Chris on GLP-1s, Arch Manning and Hollywood Smothers, cyber cabs, Scottish sayings, Craig Way and Big Bertha, Big Top Candy, JB's prednisone fail, and Sandy's stolen car-wash routine.If you laughed, subscribe, leave a review, and share The JB and Sandy Show with a friend who needs it.

In 2015, Andrew Allers was hit and fell while competing in a soccer match.  He immediately sought medical attention. and a CT scan revealed a baseball-sized tumor on one of his kidneys, which led to a diagnosis of Stage III renal cell carcinoma, or, kidney cancer.  A radical open-assisted nephrectomy removed the entire cancerous kidney.  Andrew thought he was in the clear, but in 2019, he was diagnosed with Stage IV kidney cancer.  Not only that, but the cancer had spread to his bones and his brain.  However, all of the above was successfully treated with an immunotherapy regimen, including ipilimumab and nivolumab.  Physically, Andrew considers his health at about 65 percent of what it was pre-diagnosis, but his cognitive skills are just as sharp as ever.   Andrew Allers led an active lifestyle in 2015.  From suburban Connecticut, he commuted to his job on Wall Street, but still found the time and energy to compete in an over-40 soccer league.  It was during a match that he took a hit, fell on his side.  Not only did he think he had broken a rib, but there was blood in his urine.  He went to the emergency department.  A CT scan was ordered, and it revealed a baseball-sized mass on his kidney.  Andrew was referred to a urologist, who checked out the scan and told Andrew he had Stage III kidney cancer.   A radical open-assisted nephrectomy was performed to successfully remove the cancerous kidney.  However, just two years later while playing tennis, he felt a pain in his back.  A biopsy was performed and Stage IV kidney cancer was indicated.  In addition, Andrew underwent a bone scan which revealed a tumor in his left hip socket.  It was radiated immediately, but to be safe, he was put on an immunotherapy regimen with two agents, ipilimumab and nivolumab.  Side effects included a full body rash and muscle aches making it difficult to make up and down stairs.  The immunotherapy was supplemented with a rheumatological drug, IVIG, or intravenous immunoglobin.  A few months later, his tumors had shrunk measurably.    There was yet another issue for Andrew.  He experienced problems with his left field of vision, and underwent a CT scan, which he had a pair of brain tumors.  For that he underwent a successful surgical procedure in May 2020.    These days from a physical perspective, Andrew Allers says his health is about 65 percent of what it was before his soccer accident. His biggest setback is that he can no longer run. He says his cognitive skills have not suffered and that his mental health is better than ever.   Additional Resources:   Support Group:   The Kidney Cancer Association  https://www.kidneycancer.org   Patients Stories Andrew has written for The Kidney Cancer Association:   https://www.kidneycancer.org/andrew-allers/   https://www.kidneycancer.org/andrew-allers-plan/  

D&P Highlight: Sam is never allowed to take prednisone again. full 671 Fri, 21 Aug 2026 18:57:00 +0000 lZP18Gipj90TdEdOWLirnRdTPx1QifL7 news The Dana & Parks Podcast news D&P Highlight: Sam is never allowed to take prednisone again. You wanted it... Now here it is! Listen to each hour of the Dana & Parks Show whenever and wherever you want! © 2025 Audacy, Inc. News https://player.amperwavepodcastin

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Beyond Cholesterol: The Heart Health Markers That Matter [0:00:00] – Intro: Lettuce Contamination, Social Media & Local Business Impact Discussion of “fear of lettuce,” limited to 15 states (not Tennessee) How social media amplifies food scares Local “Build a Salad” restaurant going out of business and timing around lettuce scare [0:04:39] – Back-to-School Immune Support: Oral Probiotics & Iodine Nasal Spray Back-to-school season and rise in colds/sicknesses Oral probiotics for kids: oral microbiome, throat/sinus benefits Iodine nasal spray for parents and teachers: safety, use during school/gym, personal routines of Ed and Clint [0:08:04] – Supplement Industry & Big Pharma Buyouts Thorne bought by Procter & Gamble for $3.8B History of pharma mocking “granola/hippie” supplement culture, now buying brands Many acquired supplement brands failing under pharma ownership Difference between pharma customers and nutraceutical users (education, mindset) Nutrition World's preference for privately owned brands [0:14:00] – Life Lessons from Flying & Racing: Doing the Hard but Right Thing Ed's story: practicing engine-out landings, re-learning best glide speed Insight: sometimes you must “point the nose down” (do the counterintuitive hard thing) to survive Clint's race-car analogy: “you go where you look” – look down the track, not at the wall [0:18:01] – Food Label Claims: Olive Oil vs. Avocado Oil Products UC Davis testing of products “made with olive oil” – most passed authenticity tests Avocado-oil-labeled products often failing purity tests Takeaway: be more skeptical of “made with avocado oil” claims [0:18:31] – Prostate Cancer & “Treating the Terrain,” Not Just the Tumor Dr. Gio (prostate-focused naturopath): focus on the ground cancer grows in Historical context from Stephen Paget's work on tumor “soil and seed” Lifestyle “soil-building” recommendations: Resistance training, walking 150 minutes/week Waist circumference < half your height Sleep, stress reduction, nutraceuticals, nutrient-dense diet [0:21:58] – Multivitamins, Carotid Stenosis & Functional Benefits COSMOS study: Centrum multivitamin and patients with carotid narrowing Reported improvements in physical function (walking, climbing stairs) and symptoms (shortness of breath, fatigue) Ed's extrapolation: better-designed multis (True Grace, Life Extension, etc.) likely offer even more benefit [0:22:30] – Post-Infectious Cough: Honey + Instant Coffee vs. Prednisone Double-blind RCT comparing: Honey + instant coffee paste Prednisone Guaifenesin Honey + instant coffee dramatically outperformed prednisone in reducing persistent cough frequency Discussion of guaifenesin's role, safety, and its regulatory history in health food vs. pharmacy channels [0:30:12] – Prednisone, COVID & Anxiety: Personal Case Story Guest Dr. Curt Dearing shares: Followed COVID protocol including prednisone Developed severe, prolonged anxiety afterward (twice) Realization that prednisone triggered it Ed's summary of prednisone side effects: bone loss, cataracts, muscle wasting, weight gain; okay short term, risky long term [0:33:30] – Cardiovascular Disease, Statins, & New Drug Lifendra (PCSK9 Inhibitor Pill) CV disease framed as leading cause of death for most people Introduction of Lifendra (oral PCSK9 inhibitor, from Merck) as “breakthrough” LDL-lowering drug Comparison with Repatha (injectable PCSK9 inhibitor) Curt's key points: Lifendra lowers LDL but does not show reduction in cardiovascular death, heart attack, or stroke (per Merck's own wording so far) Repatha's trial data: minimal impact on non-fatal events; no reduction in CV deaths vs. placebo Very high cost (~$300+/month out of pocket; heavy insurance burden) Critique of LDL obsession in cardiology Need to ask: Why is the cardiovascular system inflamed and oxidized? Ed & Curt's “terrain” model: Bad inputs: ultra-processed food, toxins, poor sleep, chronic stress, lack of sun/movement Missing inputs: nutrient-dense foods, minerals, omega-3s, organ meats, sunlight, sleep, movement Example of amlodipine: lowers BP numbers but may increase arterial calcification (calcium channel blocker) For people unwilling to change lifestyle, drugs may offer marginal benefit—but not true health [0:41:05] – Curt's Book & Lab Markers That Matter More Than LDL-C Curt's book: “Beyond Cholesterol: The Ultimate Guide to Testing and Supplements for Heart Health” Emphasis on better markers: ApoB, LDL particle size/number, calcium score, etc. Book's Amazon performance briefly noted (new release bestseller in its category) [0:44:32] – Alternatives to Statins & PCSK9s: Bergamot & Lifestyle Curt's hierarchy: Lifestyle (diet, exercise, stress, sleep) Targeted supplements like bergamot (citrus extract): lowers harmful particles such as ApoB and supports “good” LDL function Only then consider pharmaceuticals, and very selectively Skepticism about recommending Lifendra at all; strong bias toward non-drug approaches [0:45:28] – Dr. Wolfson, Mold, and Cardiovascular Terrain Ed & Curt's respect for Dr. Jack Wolfson, “The Natural Heart Doctor” Mention of mold as a major, under-recognized driver of cardiovascular disease Reference to Dr. Wolfson's educational resources and upcoming podcast plans [0:48:04] – Key Takeaways on Lifendra & Heart Prevention Strategy Lifendra will not fix: seed oils, glyphosate exposure, mold, bad sleep, chronic stress Terrain-building priorities: Real food, omega-3s, sunlight Toxin reduction Mitochondrial support Foundational supplements Contrast: drugs = band-aids with side effects; nutraceuticals = “side benefits” when used correctly [0:52:28] – Wrap-Up Ed mentions Sprouts selling lab-grown meat and his strong opposition Update on Oura Ring: now tracking nighttime blood pressure and importance of BP dipping Listener story: young man post–heart surgery credits Nutrition World's education and support with changing his life Final thanks to Dr. Dearing and closing outro  The post Radio Show / Podcast – August 9, 2026 first appeared on Vital Health Radio.

The post “Please sir, I want some more:” When Rescue Becomes Routine With Prednisone in IBD Care appeared first on JDDonline - Journal of Drugs in Dermatology.

The post “Please sir, I want some more:” When Rescue Becomes Routine With Prednisone in IBD Care appeared first on JDDonline - Journal of Drugs in Dermatology.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Becca: Hi Dr. Cabral! My husband is challenged by a "cobalt conundrum". Several years back he was overexposed to wet cement, spending hours mixing it with his hands. (Big mistake) Shortly after he developed a severe body rash along with painful cramps and diarrhea. After many tests, they found an allergy to cobalt via a skin test, and we assume it relates to the cement mixing incident. Severely limiting cobalt both topically and in diet has helped, but he still struggles with GI issues. Functional medicine tests showed leaky gut. He attempted treatment but even one basic supplement (dairy free igg) caused severe stomach issues. Meanwhile he's missing vital nutrients from avoiding b12 (cobalt) etc. How can he address leaky gut and allergies when he's so sensitive to treatments? Signed, Your Fan       Ally: Hi Dr. Cabral, I am a new Level 2 graduate and I have a new client who is 20-years old with a history of anorexia. she is 5-years post treatment. She complains of bloating, constipation, and just having trouble eating. She is of normal weight, and is looking for relief. I was thinking of doing the Big 3 labs and the CBO protocol.. Any recommendations would be very appreciated. I do not want to recommend the wrong plan of care for her. Warmest regards, Ally :)      Tommy: Hey Dr. C, I'm an IHP, 36. Had a birth defect, 3 operations by the age of 8 including tonsillectomy. Sleep issues began at 9, insomnia by 12, eczema, fainting, 14 years of steroid creams and thousands of antibiotics. I've got high heavy metals and Citrabacter freundi. I can't tolerate any protocols even at a lower dose, they make my existing problems worse. On days where I train intensely I struggle to shut off. I feel like my body is always stuck in a low level of stress. I've cut down my training a lot but I'm not sure what else I can do. I'm tolerating zinc Carnosine which helps but I still always have red skin on my face. Still struggle to tolerate stress. If only I could do a heavy metal protocol.       Sarah: Hi! Hope you are well and love tuning in daily to learn from you! I have been trying to heal leaky gut and chronic hives for over a decade now. Because I am very reactive I stop and start a lot. However, I recently gave in and started a low dose prednisone and over a couple weeks lost 10lbs of inflammation, hives gone, that I couldn't break with any diet (restriction), exercise etc. I would like to do some testing and do the CBO protocol as this started after antibiotics. My question is, will this skew the results of cortisol/A1C and will it be okay to continue on to keep symptoms calm while getting to the root and going through some protocols? Thanks! (BTW) I have tried all the natural stabilizers and didn't help calm symptoms. (Quercetin, Vit C, Mag, etc)       Sienna: Hi Dr. Cabral, this is a follow up to my question on 3782 re testing for perimenopause please. Thank you for your guidance and if I could run EL labs I would. I have NO access to Saliva Testing in my country (and EL don't ship here). So I know about SMM & Fertility Labs but can't run them so I am *specifically* asking IF estrogen & progesterone tested by an endocrinologist (BLOOD) have ANY value as a way to look at levels? LH, FSH & AMH are great as I can get these from bloods, can you please provide the healthy ranges vs. perimenopause? Would really appreciate it as this is the only option I have to look deeper & PCP here don't have a functional approach so really value your guidance on anything you can share to help me support my body. Thank-you, Sienna     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3817 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

With multiple clinical trials evaluating PARP inhibitor combinations, how do clinicians determine the best approach for advanced prostate cancer? In this episode of BackTable Urology, Dr. Alan Tan is joined by Dr. Rana McKay and Dr. Emmanuel Antonarakis to discuss how evolving evidence, patient selection, timing, toxicity, and genetic testing are shaping the use of PARP inhibitor combinations in clinical practice. --- Get the BackTable apphttps://www.backtable.com/app --- This podcast is supported by an educational grant from Pfizer. --- Timestamps 00:00 - Introduction02:51 - PARPi Basics14:12 - Major Study Differences19:00 - Timing and Selection of PARPi Combinations26:39 - Case: Somatic BRCA2 loss and mHSPC35:51 - Case Continued: BRCA2 Reversion39:57 - BRCAAway Study42:59 - Takeaways from the 2026 APCCC --- More about this episode The conversation reviews lessons learned from major clinical trials, including PROpel, MAGNITUDE, TALAPRO-2, and AMPLITUDE, and addresses how these studies inform real-world treatment choices. The doctors dig into case examples, such as BRCA2 loss and reversion, and highlight practical strategies for using germline and somatic testing to personalize care. Key insights from the 2026 Advanced Prostate Cancer Consensus Conference are also shared, emphasizing the importance of precision medicine in this rapidly evolving field. --- Resources Study on Olaparib Plus Abiraterone as First-line Therapy in Men With Metastatic Castration-resistant Prostate Cancer (PROpel) https://clinicaltrials.gov/study/NCT03732820 A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer (MAGNITUDE) https://clinicaltrials.gov/study/NCT03748641?tab=study Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC (TALAPRO-2) https://clinicaltrials.gov/study/NCT03395197 A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) (AMPLITUDE) https://clinicaltrials.gov/study/NCT04497844 BRCAAway: A randomized phase 2 trial of abiraterone, olaparib, or abiraterone + olaparib in patients with metastatic castration-resistant prostate cancer (mCRPC) bearing homologous recombination-repair mutations (HRRm) https://pubmed.ncbi.nlm.nih.gov/39115414/ --- BackTable Urology is the go-to podcast for urologists, urologic oncologists, and urogynecologists. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app

To have Dr. Morse answer a question, visit: https://drmorses.tv/ask/ All of Dr. Morse's and his son's websites under one roof: https://handcrafted.health/ Facebook Page: https://www.facebook.com/handcrafted.health 00:00:00 - Intro - New Herbal Formulas! 00:08:20 - Thyroid Nodules 00:41:27 - Corticosteroids 01:10:16 - Tinnitus 01:28:47 - Lupus - Flare-up on nose and fingers 01:39:21 - Food Aversion - Allergies 00:08:20 - Thyroid Nodules They can't tell me 100% that I have cancer, so that has prevented me from removing them. 00:41:27 - Corticosteroids So I wanted to bring up a topic of Cortisone and Prednisone. 01:10:16 - Tinnitus It started a few months after I gave birth and has stayed for a whole year. 01:28:47-  Lupus - Flare-up on nose and fingers My mom has had lupus for over 30 years and has used a wide variety of allopathic medicines. 01:39:21 - Food Aversion - Allergies I'm wondering if people who have a life-long allergy to onion, like myself, can ever "get over it"?

The post The Devil Wears Prednisone: A Women's Health Perspective on Corticosteroid Stewardship appeared first on JDDonline - Journal of Drugs in Dermatology.

Can someone with seropositive rheumatoid arthritis (high CCP, inflammatory synovitis, severe flare) go into full remission without long-term medication?In this powerful interview, Dr. Isabelle Amigues speaks with Brandon, a patient diagnosed with textbook rheumatoid arthritis who experienced:• Severe joint inflammation• High anti-CCP antibodies• Debilitating flares• Prednisone and methotrexate treatment• Biologic therapy (Kevzara)After a profound turning point, Brandon explored:• Vagus nerve stimulation• Stress reduction & nervous system regulation• Meditation & humming techniques• Anti-inflammatory nutrition• Exercise & muscle rebuilding• Body awareness & alignmentToday, he has been in full remission for over 6 months without medication.This episode explores:• The role of stress in autoimmune disease• Vagus nerve stimulation and inflammation• Can RA remission happen naturally?• The bridge between Western medicine and nervous system healing• Why remission is the goal — no matter the pathThis is not medical advice. This is a story of possibility, partnership, and personalized care.If you'd like access to our vagus nerve stimulation webinar, comment below.

It's good to be back! Today I'm sharing my experience of sudden sensorineural hearing loss (SSNHL) a couple of months ago, and the aftermath that's unfolded since.I know this is a deviation from my usual topics, but I'd love people to be informed in case you or a loved one suddenly loses hearing. Sudden sensorineural hearing loss is considered a medical emergency, but is often missed by medical professionals.I'll be back to my usual Private Practice Skills antics next week :)Thank you to Paubox for sponsoring this episode. Paubox makes HIPAA-secure email easy and streamlined. Check them out here:https://bit.ly/pps_paubox_spotify*Get $250 off your first year with Paubox with coupon code "SKILLS"*Bonus Deal:* If you add the Paubox badge to your website you get an extra $100 off your first year - that means you can get your whole first year free if you apply both deals!Shoutout to my brother, Data Time, for requesting this episode:https://www.youtube.com/@DataTime27His channel is like, much cooler than mine :)Article: "Early and Accurate Diagnosis of Sudden Sensorineural Hearing Loss"https://pmc.ncbi.nlm.nih.gov/articles/PMC3034434/Article: "Prednisone withdrawal: Why taper down slowly?"https://www.mayoclinic.org/diseases-conditions/inflammatory-bowel-disease/expert-answers/prednisone-withdrawal/faq-20057923Article: “Hyperbaric Oxygen Therapy”https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/hyperbaric-oxygen-therapyArticle: "10 Things to Know About Medical Grade HBOT (And Why It's Different)”https://www.cns-center.com/blog/10-things-to-know-before-your-medical-hyperbaric-oxygen-session-at-cnsArticle: "Ruptured eardrum (perforated eardrum)"https://www.mayoclinic.org/diseases-conditions/ruptured-eardrum/symptoms-causes/syc-20351879Article: "Risk Factors for Middle Ear Barotrauma in Patients with Carbon Monoxide Poisoning Undergoing Monoplace Hyperbaric Oxygen Therapy: A Retrospective Cohort Study"https://www.mdpi.com/2077-0383/14/9/2984Article: "The Hidden Risks of Hearing Loss"https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-hidden-risks-of-hearing-lossArticle: "How Hearing Loss Accelerates Cognitive Decline"https://www.pacificneuroscienceinstitute.org/blog/neuro-conditions-cognitive/understanding-the-link-between-hearing-loss-and-cognitive-decline-key-insights-and-prevention-strategies/LINKS:*Some links are affiliate links. A percentage of purchases come back to me and help my channel immensely!

Pop Pop on Prednisone full 130 Fri, 20 Mar 2026 14:17:14 +0000 a5XnGB5nvOVCnY6y0nIWsFiegsCXsyl3 society & culture The Doc Show society & culture Pop Pop on Prednisone The Doc Show with Jessie   2024 © 2021 Audacy, Inc. Society & Culture False https://player.amperwavepodcasting.com?feed-link=https%3A%2F%2Frss.ampe

Herbal supplements are generally safe, but are there some dangerous herbs you should be aware of? Discover the natural remedy that can cause high blood pressure in certain people, and what to take instead.

Today, Dave Furfaro, Luke Hedrick, and Robert Wharton discuss the PREDMETH trial published in The New England Journal of Medicine in 2025. This was a non-inferiority trial comparing prednisone to methotrexate for upfront therapy in treatment-naive sarcoidosis patients. Listen in for a break down of the trial, analysis, and clinically applicable pearls. Article and Reference Todays’ episode discusses the PREDMETH trial published in NEJM in 2025. Kahlmann V, Janssen Bonás M, Moor CC, Grutters JC, Mostard RLM, van Rijswijk HNAJ, van der Maten J, Marges ER, Moonen LAA, Overbeek MJ, Koopman B, Loth DW, Nossent EJ, Wagenaar M, Kramer H, Wielders PLML, Bonta PI, Walen S, Bogaarts BAHA, Kerstens R, Overgaauw M, Veltkamp M, Wijsenbeek MS; PREDMETH Collaborators. First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate. N Engl J Med. 2025 Jul 17;393(3):231-242. doi: 10.1056/NEJMoa2501443. Epub 2025 May 18. PMID: 40387020. https://www.nejm.org/doi/full/10.1056/NEJMoa2501443 Meet Our Hosts Luke Hedrick is an Associate Editor at Pulm PEEPs and runs the Rapid Fire Journal Club Series. He is a senior PCCM fellow at Emory, and will be starting as a pulmonary attending at Duke University next year. Robert Wharton is a recurring guest on Pulm PEEPs as a part of our Rapid Fire Journal Club Series. He completed his internal medicine residency at Mt. Sinai in New York City, and is currently a first year pulmonary and critical care fellow at Johns Hopkins. Key Learning Points Clinical context Prednisone remains the traditional first-line treatment for pulmonary sarcoidosis when treatment is indicated, with evidence for short-term improvements in symptoms, radiographic findings, and pulmonary function—but with substantial, familiar steroid toxicities (weight gain, insomnia, HTN/DM, infection risk, etc.). Despite widespread use, glucocorticoids haven't been robustly tested head-to-head against many alternatives as initial therapy, and evidence for preventing long-term decline (especially in severe disease) is limited. Immunosuppressants (like methotrexate) are often used as steroid-sparing agents, but guideline recommendations are generally conditional/low-quality evidence, and practice varies. Why PREDMETH matters It addresses a real-world question: Can methotrexate be an initial alternative to prednisone in pulmonary sarcoidosis, rather than being reserved only for steroid-sparing later? It also probes a common clinical belief: MTX has slower onset than prednisone (often assumed, not well-proven). Trial design (what to know) Open-label, randomized, noninferiority trial across 17 hospitals in the Netherlands. Included patients with pulmonary sarcoidosis who had a clear pulmonary indication to start systemic therapy (moderate/severe symptoms plus objective risk features like reduced FVC/DLCO or documented decline, plus parenchymal abnormalities). Excluded: non–treatment-naïve patients and those whose primary indication was extrapulmonary disease. Treat-to-tolerability with escalation: both drugs started low and were slowly increased; switch/add-on allowed for inadequate efficacy or unacceptable side effects. Primary endpoint: change in FVC (with the usual caveat that FVC is “objective-ish,” but effort-dependent and not always patient-centered). Noninferiority margin: 5% FVC, justified as within biologic/measurement variation and “not clinically relevant.” Outcomes assessed at weeks 4, 16, 24; powered for ~110 patients to detect the NI margin. Patient population (who this applies to) Mostly middle-aged (~40s) with mild-to-moderate physiologic impairment on average (FVC ~77% predicted; DLCO ~70% predicted). Netherlands-based cohort with limited Black representation (~7%), which matters for generalizability. Would have been helpful to know more about comorbidities (e.g., diabetes), which can strongly influence prednisone risk. Main findings (what happened) Methotrexate was noninferior to prednisone at week 24 for FVC: Between-group difference in least-squares mean change at week 24: −1.17 percentage points (favoring prednisone) with CI −4.27 to +1.93, staying within the 5% NI margin. Timing mattered: Prednisone showed earlier benefit (notably by week 4) in FVC and across quality-of-life measures. By week 24, those early differences largely washed out—possibly because MTX “catches up,” and/or because crossover increased over time. In their reporting, MTX didn't meet noninferiority for FVC until week 24, supporting the practical message that prednisone works faster. Crossover and analysis nuance (important for interpretation) Crossover was fairly high, which complicates noninferiority interpretation: MTX arm: some switched to prednisone for adverse events and others had prednisone added for disease progression/persistent symptoms. Prednisone arm: some had MTX added. In noninferiority trials, heavy crossover can bias intention-to-treat analyses toward finding “no difference” (making noninferiority easier to claim). Per-protocol analyses avoid some of that but introduce other biases. They reported both. Safety signals (what to remember clinically) Adverse events were very common in both arms (almost everyone), mostly mild. Side-effect patterns fit expectations: Prednisone: more insomnia (and classic steroid issues). MTX: more headache/cough/rash, and notably liver enzyme elevations (about 1 in 4), with a small number discontinuing. Serious adverse events were rare; numbers were too small to confidently separate “signal vs noise,” but overall known risk profiles apply. Limitations (why you shouldn't over-read it) Open-label design, and FVC—while objective-ish—is still effort-dependent and can be influenced by expectation/behavior. Small trial, limiting subgroup conclusions (e.g., severity strata, different phenotypes). Generalizability issues (Netherlands demographics; US populations have higher rates of obesity/metabolic syndrome, which may tilt the steroid risk-benefit equation). Crossover reduces precision and interpretability of between-group differences over time. Practice implications (the “so what”) For many patients with pulmonary sarcoidosis needing systemic therapy, MTX is a reasonable initial alternative to prednisone when thinking long-term tolerability and steroid avoidance. Prednisone likely provides faster symptom/QoL relief in the first weeks—so it may be preferable when rapid improvement is important. The trial strengthens the case for a patient-centered discussion: short-term relief vs side-effect tradeoffs, and the possibility of early combination therapy in more severe cases (suggested, not proven).

This week, I am back from a week in Vegas! I reunited with the kids, responded to all the news (rumors and nastiness!) coming out of BravoCon, but you know what? I think this year, it was about reconciliations and coming together!Then, I had Lucy's parent-teacher conference, got called a bossy Daddy, and received a funny DM from a high school student.For more interviews and behind-the-scenes tea, tune in to Andy Cohen Live weekdays on Radio Andy by subscribing to SiriusXM. Use my link https://sxm.app.link/AndyCohen for a free trial! Subscribe to SiriusXM Podcasts+ to listen to new episodes of Daddy Diaries ad-free and a whole week early. Start a free trial now on Apple Podcasts or by visiting siriusxm.com/podcastsplus. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dystrophinopathies are heritable muscle disorders caused by pathogenic variants in the DMD gene, leading to progressive muscle breakdown, proximal weakness, cardiomyopathy, and respiratory failure. Diagnosis and management are evolving areas of neuromuscular neurology. In this episode, Kait Nevel, MD, speaks with Divya Jayaraman, MD, PhD, an author of the article "Dystrophinopathies" in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Nevel is a Continuum® Audio interviewer and a neurologist and neuro-oncologist at Indiana University School of Medicine in Indianapolis, Indiana. Dr. Jayaraman is an assistant professor of neurology and pediatrics in the division of child neurology at the Columbia University Irving Medical Center in New York, New York. Additional Resources Read the article: Dystrophinopathies Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @IUneurodocmom Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Nevel: Hello, this is Dr Kate Nevel. Today I'm interviewing Dr Divya Jayaraman about her article on dystrophinopathies, which she wrote with Dr Partha Ghosh. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Divya, welcome to the podcast, and please introduce yourself to the audience. Dr Jayaraman: Thank you so much, Dr Nevel. My name is Divya, and I am an assistant professor of Neurology and Pediatrics at Columbia University Irving Medical Center, and also an attending physician in the Pediatric Neuromuscular program there. In that capacity, I see patients with pediatric neuromuscular disorders and also some general pediatric neurology patients and also do research, primarily clinical research and clinical trials on pediatric neuromuscular disorders. Dr Nevel: Wonderful. Thank you for sharing that background with us. To set us on the same page for our discussion, before we get into some more details of the article, perhaps, could you start with some definitions? What comprises the dystrophinopathies? What are some of the core features? Dr Jayaraman: So, the dystrophinopathies, I like that term because it is a smaller subset from the muscular dystrophies. The dystrophinopathies are a spectrum of clinical phenotypes that are all associated with mutations in the DMD gene on chromosome X. So, that includes DMD---or, Duchenne muscular dystrophy---, Becker muscular dystrophy, intermediate muscular dystrophy (which falls in between the two), dilated cardiomyopathy, asymptomatic hyperCKemia, and manifesting female carriers. In terms of the core features of these conditions, so, there's some variability, weakness being prominent in Duchenne and also Becker. The asymptomatic hyperCKemia, on the other hand, may have minimal symptoms and might be found incidentally by just having a high CK on their labs. They all will have some degree of elevated CK. The dilated cardiomyopathy patients, and also the Becker patients to a lesser degree, will have cardiac involvement out of proportion to skeletal muscle involvement, and then the manifesting carriers likewise can have elevated CK and prominent cardiac involvement as well as some milder weakness. Dr Nevel: Now that we have some definitions, for the practicing neurologists out there, what do you think is the most important takeaway from your article about the dystrophinopathies? Dr Jayaraman: I like this question because it suggests that there's something that, really, any neurologist could do to help us pick up these patients sooner. And the big takeaway I want everyone to get from this is to check the CK, or creatine kinase, level. It's a simple, cheap, easy test that anyone can order, and it really helps us a lot in terms of setting the patient on the diagnostic odyssey. And in terms of whom you should be thinking about checking a CK in, obviously patients who present with some of the classic clinical features of Duchenne muscular dystrophy. This would include young boys who have toe walking, as they're presenting, sign; or motor delayed, delayed walking. They may have calf hypertrophy, which is what we say nowadays. You might have seen calf pseudohypertrophy in your neurology textbooks, but we just say calf hypertrophy now. Or patients can often have a Gowers sign or Gowers maneuver, which is named after a person called Gowers who described this phenomenon where the child will basically turn over and use their hands on the floor to stand up, usually with a wide-based gait, and then they'll sort of march their hands up their legs. That's the sort of classic Gowers maneuver. There are modified versions of that as well. So, if anyone presents with this classic presentation, for sure the best first step is to check a CK. But I would also think about checking a CK for some atypical cases. For example, any boy with any kind of motor or speech delay for whom you might not necessarily be thinking about a muscle disorder, it's always good practice to check a CK. Even a boy with autism for whom you may not get a good clinical exam. This patient might present to a general pediatric neurology clinic. I always check a CK in those patients, and you'll pick up a lot of cases that way. For the adult folks in particular, the adult neurologist, a female patient could show up in your clinic with asymptomatic hyperCKemia. And I think it's an important differential to think about for them because this could have implications not just for their own cardiac risks, but also for their family planning. Dr Nevel: So, tell us a little bit more about the timing of diagnosis. Biggest takeaway: check a CK if this is anywhere on your radar, even if somewhat of an atypical case. Why is it so important to get kiddos started on that diagnostic odyssey, as you called it, early? Dr Jayaraman: This is especially important for kids because if they especially get a Duchenne muscular dystrophy diagnosis, you might be making them eligible for treatments that we've had for some time, and also treatments that were not available earlier that hinge on making that diagnosis. So, for example, people may be skeptical about steroids, but there's population data to suggest that initiation and implementation of steroids could delay the onset of loss of ambulation as much as three years. So, you don't want to deprive patients of the chance to get that. And then all the newer emerging therapies---which we'll be talking about later, I'm sure---require a Duchenne muscular dystrophy diagnosis. So, that's why it's so important to check a CK, have this on your radar, and then get them to a good specialist. Dr Nevel: I know that you alluded already, or shared a few of the kind of exam paroles or findings among patients with dystrophinopathy. But could you share with us a little bit more how you approach these patients in the clinic who are presenting with muscle weakness, perhaps? And how do you approach this or think about this in terms of ways to potentially differentiate between a dystrophinopathy versus another cause of motor weakness or delay? Dr Jayaraman: It's helpful to think through the neuraxis and what kinds of disorders can present along that neuraxis. A major differential that I'm always thinking about when I'm seeing a child with proximal weakness is spinal muscular atrophy, which is a genetic anterior horn cell disorder that can also present in this age group. And some of the key differences there would be things like reflexes. So, you should have dropped reflexes in spinal muscular atrophy. In DMD, surprisingly, they might have preserved Achilles reflexes even if their patellar reflexes are lost. It may only be much later that they go on to lose their Achilles reflex. So, if you can get an Achilles reflex, that's quite reassuring, and if you cannot, then you need to be thinking about spinal muscular atrophy. They can both have low muscle tone and can present quite similarly, including with proximal weakness, and can even have neck flexion weakness. So, this is an important distinction to make. The reason for that is, obviously there are treatments for both conditions, but for spinal muscular atrophy, timing is very, very important. Time is motor neurons, so the sooner you make that diagnosis the better. Other considerations would be the congenital muscular dystrophies. So, for those that they tend to present a lot younger, like in infancy or very early on, and they can have much, much higher CKS in that age range than a comparable Duchenne or Becker muscular dystrophy patient. They can also have other involvement of the central nervous system that you wouldn't see in the dystrophinopathies, for example. My mnemonic for the congenital muscular dystrophies is muscle-eye-brain disease, which is one of the subtypes. So, you think about muscle involvement, eye involvement, and brain involvement. So, they need an ophthalmology valve. They can have brain malformations, which you typically don't see in the dystrophinopathies. I think those are some of the major considerations that I have. Obviously, it's always good to think about the rest of the neuraxis as well. Like, could this be a central nervous system process? Do they have upper motor neuron signs? But that's just using all of your exam tools as a neurologist. Dr Nevel: Yeah, absolutely. So, let's say you have a patient in clinic and you suspect they may have a dystrophinopathy. What is your next diagnostic step after your exam? Maybe you have an elevated CK and you've met with the patient. What comes next? Dr Jayaraman: Great question. So, after the CK, my next step is to go to genetics. And this is a bit of a change in practice over time. In the past we would go from the CK to the muscle biopsy before genetic testing was standard. And I think now, especially in kids, we want to try and spare them invasive procedures where possible. So, genetic testing would be the next step. There are a few no-charge, sponsored testing programs for the dystrophinopathies and also for some of the differential diagnosis that I mentioned. And I think we'll be including links to websites for all of these in the final version of the published article. So, those are a good starting point for a genetic workup. It's really important to know that, you know, deletions and duplications are a very common type of mutation in the DMD gene. And so, if you just do a very broad testing, like whole exome, you might miss some of those duplications and deletions. And it's important to include both checking for duplications and deletions, and also making sure that the DMD gene is sequenced. So always look at whatever genetic test you're ordering and making sure that it's actually going to do what you want it to do. After genetics, I think that the sort of natural question is, what if things are not clear after the genetics for some reason? We still use biopsy in this day and age, but we save it for those cases where it's not entirely clear or maybe the phenotype is a little bit discordant from the genotype. So, for mutations that disrupt the reading frame, those tend to cause Duchenne muscular dystrophy, whereas mutations that preserve the reading frame tend to cause Becker muscular dystrophy. There are some important exceptions to this, which is where muscle biopsy can be especially helpful in sorting it out. So, for example, there are some early mutations early in the DMD gene where, basically, they find an alternate start codon or an initiation codon to continue with transcription and translation. So, you end up forming a largely functional, somewhat truncated protein that gives you more of a milder Becker phenotype. On the other hand, you can have some non-frameshift or inframe mutations that preserve the reading frame, but because they disrupt a very key domain in the protein that's really crucial for its function, you can actually end up with a much more severe Duchennelike phenotype. So, for these sorts of cases, you might know a priori you're dealing with them, but might just be a child who is who you think has DMD has a mutation that's showed up on testing. There isn't enough in the literature to point you one way or another, but they look maybe a little milder than you would expect. That would be a good kid to do a biopsy in because there are treatment decisions that hinge on this. There are treatments that are only for Duchenne that someone with a milder phenotype would not be eligible for. Dr Nevel: So, that kind of stepwise approach, but maybe not all kids need a muscle biopsy is what I'm hearing from you. If it's a mutation that's been well-described in the literature to be fitting with Duchenne, for example. Dr Jayaraman: Absolutely. Dr Nevel: So, after you confirm the diagnosis through genetic testing---and let's say, you know, whether or not you do a muscle biopsy or not, after you know the diagnosis is a dystrophinopathy---how do you counsel the families and your patients? What are the most important points to relay to families, especially in that initial phase where the diagnosis is being made? Dr Jayaraman: This is a lot of what we do in pediatric neurology in general, right? So, I actually picked up this approach from the pediatric hematology oncology specialists at Boston Children's. They had this concept of a day-zero conversation, which is the day that you disclose the life-changing diagnosis or potentially, at some point, terminal diagnosis to a family. And some of the key components of that are a not beating around the bush, telling them what the diagnosis is, and then letting them have whatever emotional response they're going to have in the moment. And you may not get much further than that, but honestly, you want them to take away, this is what my child has. I did not do anything to cause this, nor could I have done anything to prevent this. Because often for these genetic conditions, there's a lot of guilt, a lot of parental guilt. So, you want to try and assuage that as much as possible. And then to know that they're not going to be alone on this journey; that, you know, they don't have to have it all figured out right then, but we can always come back and answer any questions they have. There's going to be a whole team of specialists. We're going to help the family and the kid manage this condition. Those are sort of my big takeaways that I want them to get. Dr Nevel: Right. And that segues into my next question, which is, who is part of that team? I know that these teams that help take care of people with dystrophinopathies and other muscle disorders can be very large teams that span multiple specialists. Can you talk a little bit more about that for this group of patients? Dr Jayaraman: Of course. So, the neuromuscular neurologist, really, our role is in coordinating the diagnosis, the initiation of any disease-specific treatments, and coordinating care with a whole group of specialists. So, we're sort of at the center of that, but everyone else is equally important. So, the other specialists include physical therapists; occupational therapists; rehab doctors or physiatrists; orthotists who help with all of the many braces and other devices that they might need, wheelchairs; pulmonology, of course, for managing the respiratory manifestations of this. It becomes increasingly important over time, and they are involved early on to help monitor for impending respiratory problems. Cardiac manifestations, this is huge and something that you should be thinking about even for your female carriers, the mother of the patient you're seeing in the clinic, or your patient who comes to adult clinic with asymptomatic hyperCKemia. if you end up making a diagnosis of DMD carrier for those patients, or if you make a Becker diagnosis, the cardiac surveillance is even more important because the cardiac involvement can be out of proportion to the skeletal muscle weakness. And of course, extremely important for the Duchenne patients as well. Endocrinologists are hugely important because in the course of treating patients with steroids, we end up giving them a lot of iatrogenic endocrinologic complications. Like they might have delayed puberty, they might have loss of growth, of height; and of course metabolic syndrome. So, endocrinology is hugely important. They're also important in managing things like fracture prevention, osteoporosis, prescribing bisphosphonates if necessary. Nutrition and GI are also important, not just later on when they might need assistance to take in nutrition, whether that's through tube feeds, but also earlier on when we're trying to manage the weight. Orthopedics, of course, for the various orthopedic complications that patients develop. And then finally, a word must be said for social work and behavioral and mental health specialists, because a lot of this patient population has a lot of mental health challenges as well. Dr Nevel: After you give the diagnosis, you've counseled the patient and families and you've had those kind of initial phase discussions, the day-zero discussion, when you start getting into discussions or thoughts about management, disease-specific medication. But what are the main categories of the treatment options, and maybe how do you kind of approach deciding between treatment options for your patients? Dr Jayaraman: So, there are two broad categories that I like to think about. So, one is the oral corticosteroids and oral histone deacetylase, or HDAC inhibitors, which share the common characteristic that they are non-mutation specific. And within corticosteroids, patients now have a choice between just Prednisone or Prednisolone, or Deflazacort or Vermilion. The oral HDAC inhibitors are newly FDA-approved as a nonsteroidal therapy in addition to corticosteroids in DMD patients above six years of age. I would say we're in the early phase of adoption of this in clinical practice. And then the other big category of treatment options would be the genetic therapies as a broad bucket, and this would include gene therapy or gene replacement therapy, of which the most famous is the microdystrophin gene therapy that was FDA-approved first on an accelerated approval basis for ages four to eight, and then a full approval in that age group as well as an accelerated approval for all comers, essentially, with DMD. This is obviously controversial. Different centers approach this a bit differently. I think our practice at our site has been to focus on the ambulatory population, just thinking about risk versus benefit, because the risks are not insignificant. So really this is something that should be done by experienced sites that have the bandwidth and the wherewithal to counsel patients through all of this and to manage complications as they arise with regular monitoring. And then another class that falls within this broader category would be the Exon-skipping therapies. So as the name suggests, they are oligonucleotides that cause an Exon to be skipped. The idea is, if there is a mutation in a particular Exon that causes a frame shift, and there's an adjacent Exon that you can force skipping of, then the resulting protein, when you splice the two ends together, will actually allow restoration of the reading frame. I think the picture I want to paint is that there's a wide range of options that we present to families, not all of which everyone will be eligible for. And they all have different risk profiles. And I really think the choice of a particular therapy has to be a risk-benefit decision and a shared decision-making process between the physician and the family. Dr Nevel: What is going on in research in this area? And what do you think will be the next big breakthrough? I know before we started the recording you had mentioned that there's a lot of things going on that are exciting. And so, I'm looking forward to hearing more. Dr Jayaraman: Of course. So, I'll be as quick as I can with this. But I mentioned that next-generation Exon skipping therapies, I think the hope is that they will be better at delivering the Exon skipping to the target tissue and cells and that they might be more efficacious. I'm also excited about next-generation gene therapies that might target muscle more specifically and hopefully reduce the off-target effects, or combination use of gene therapies with other immunosuppressive regimens to improve the safety profile and maybe someday allow redosing, which we cannot do currently. Or potentially targeting the satellite cells, which are the muscle stem cells, again, to improve the long term durability of these genetic therapies. Dr Nevel: That's great, thank you for sharing. Thank you so much for talking to me today about your article. I really enjoyed learning more about the dystrophinopathies. Today I've been interviewing Dr Divya Jayaraman about her article on the dystrophinopathies, which she wrote with Dr Partha Ghosh. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Please be sure to check out the Continuum Audio episodes from this and other issues. Also, please read the Continuum articles for more details than what we were able to get to today during our discussion. Thank you, as always, so much to the listeners for joining us today, and thank you, Divya, for sharing all of your knowledge with us today. Dr Jayaraman: Thank you so much for having me on the podcast. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

Study: Mitopure's impact on immune parametersWhat important blood tests should one get, and what are the ideal levels to look for?I do coffee enemas for liver detox. How many can I do per week?  I've been on Metformin and lost some weight. Should I increase my dose to lose more?Could a recent dental implant be causing clogged ears and a hissing noise?

More on gadolinium effects and detoxI was found to have a small pericardial effusion. What advice can you give me?Is melatonin beneficial for bone mineral density? If so, how much should I take?

With a carnivore diet, San put his Ulcerative Colitis into remission and has been symptom free for 3.5 years. San has also improved severe acne and improved anxiety and depression. Instagram: https://www.instagram.com/fleshfueled/?hl=en Timestamps: 00:00 Trailer 00:29 Introduction 04:11 Misdiagnosed and dismissed for IBD 06:36 Undetected gut issues 12:15 Prednisone and biologics struggles 13:18 Final options before surgery 17:47 Misguided dietary advice consequences 20:22 Inflammation checkups and concerns 24:27 Limitations of traditional physicians 27:03 Carnivore diet for gut diseases 29:40 Diet experiment reflections 35:42 Red meat and nutrient deficiency 37:03 Health principles reflection 41:13 Where to find San Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

We have so many wonderful non-steroid options to manage itch and inflammation in veterinary dermatology. HOWEVER, there is still a time and place that steroids are necessary. It is important to not be afraid of steroids, but now when and how to use them appropriately.From stenotic ears to cost concerns, check out the situations where, even as a boarded dermatologist, I lean on steroids on this week's episode of The Derm Vet podcast!00:00 Intro01:00 Taking away guilt for steroid use02:04 Scenarios where steroid use is considered03:07 Severe Inflammation05:05 While waiting for a slower medication to work07:27 Stenotic Ears9:11 Management of autoimmune diseases11:14 Cost Concerns13:10 Sometimes nothing else works14:56 Summary/Outro

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Yvonne: Just listened to a podcast in which the doctor was recommending taking a nicotine patch everyday - starting with 1mg for 7 days and then 3 mg everday after that - supposed to be good for a variety of things but he mainly takes it to avoid getting viruses. Your thoughts on this. NOTE: You many not want to read this next sentence.                                                                                                 Sheena: Hi Dr. C! Hope you and your team are well. I'm from Canada and went for recent bloodwork and my WBC is 3.8 (I think in US measurements it is 3800). All other markers for CBC are good). I don't have any symptoms of low WBC nor do I have an autoimmune disease. This is the third year in a row my WBC has been low. Should I be concerned? Is there something I can do to help increase it? Any tests I can run? Does this mean my body cant fight infections and/or (God forbid) I get cancer? Looking forward to hearing anything you can suggest or recommend. Thank you!                                                Tricia: Hello Dr. Cabral - Ever since I was a child, I would never just get a "cold". Those little colds would turn into bronchitis or whooping cough. I would be sick for two weeks from cold induced asthma. As I've gotten older, my asthma has gotten much better but what hasn't changed is when I get a cold, I always need prednisone for me to get better. I'm 55 year old female and have been hard working hard on my health and I don't want to continue this cycle with prednisone. I feel there is something wrong and this isn't normal. Can you give me your opinion and what you think I need to work on to try to avoid this from happening. I typically get sick once a year. Any advice is helpful! I am currently taking many of your supplements to achieve my wellness journey! Thank you so much!                                                                Sheena: Hi Dr. C! Hope you and your team are well. I'm a 45 yo female and have started taking creatine monohydrate because I heard all good things. I take it everyday, first thing in the morning, in my protein shake or in my coffee but I'm noticing loose stool. Is this normal? Am I taking too much (5gl)? Do I need to ease into it? Does it benefit women in perimenopause? Is it better to take before, during or after a workout? I've listened to all your podcasts that you discuss creatine but I'm still confused. Looking forward to hearing your suggestions and recommendations. Thx in advanced for your help!                                                                                                                                                                                       Bettina: Hi Dr. Cabral. What are your thoughts on specialized lipedema surgery, like the one Dr. performs in Madrid? I follow his clinic on Instagram and have heard positive things about it, as well as from some clinics in Germany where lipedema is acknowledged.     Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3529 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Drs. Petri and Fava discuss updated guidelines for the screening, treatment, and management of lupus nephritis.

An update on natural thyroid availability and the FDAA correction on disseminated sarcoidosis and stressI'm a former smoker. Should I be concerned about beta carotene in the Alpha Base multivitamin?A comment from a user of lithium orotate for the last eleven yearsDoes long-term use of Horse Chestnut cause a thiamin deficiency?

A new NEJM trial found methotrexate offers similar lung function improvements as prednisone in pulmonary sarcoidosis, but with fewer side effects—suggesting it could be a safer first-line option for some patients. A JAMA study revealed that patients trust physicians less when AI is mentioned in care ads, highlighting the importance of framing AI as a tool that supports—not replaces—clinical judgment. Another NEJM trial showed that giving take-home ondansetron to children after ED visits for gastroenteritis significantly reduced vomiting and return visits, with no added risks. Together, these studies support a shift toward individualized care, better patient communication, and practical interventions to improve outcomes.

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright open the Fat Science mailbag to answer listener questions from around the globe. This episode covers real-world metabolic challenges—from navigating calorie restriction and GLP-1 medications to the complexities of bariatric surgery, prednisone's impact on weight, and menopause. Dr. Cooper offers clear explanations and practical advice for healthcare professionals and patients alike on understanding metabolic dysfunction, interpreting lab results, and setting realistic weight loss expectations.Key Takeaways:Calorie restriction and intermittent fasting can destabilize metabolism, making recovery complex for some patients—gradual changes and medical monitoring are essential.Bariatric surgery can be an effective intervention for those with significant insulin resistance or high hunger signals. Pre-surgery metabolic testing (like insulin, glucose, and ghrelin levels) is valuable in assessing the likely benefit.Plateaus after surgery, persistent weight struggles, and the role of genetics highlight the need for root-cause investigation, not just symptom management.Prednisone and hormone therapies (including MHT for menopause) can affect metabolic health; small dietary adjustments, body composition testing, and tailored exercise are crucial for optimizing outcomes.Guidance on GLP-1 medication maintenance: Most patients benefit from staying on weight loss meds long-term, but dose adjustment is possible when side effects arise. Stability over many months is critical before considering any taper.Personal Stories & Practical Advice:Andrea shares her experience with bariatric surgery and ongoing metabolic management, emphasizing realistic expectations and the benefit of medication-surgery synergy.Listeners ask: how to evaluate readiness to stop weight loss meds, address side effects, and balance hormone needs during menopause.Resources from the episode:Fat Science is a podcast on a mission to share the real science behind why we get fat, addressing stigma and confusion with facts, hope, and empowering stories.Updates on Dr. Cooper's upcoming virtual metabolic health training—ideal for practitioners in the UK and beyond.Information about Melanocortin pathway testing programs for severe, persistent obesity.https://uncoveringrareobesity.com/Link to previous show. “GLP-1s: Will I Have to Take Them Forever?” (5/19/25)https://open.spotify.com/episode/1GZA71gTMSz0idbnEYblVO?si=gJXxNkbYTHykhNDw0Ebltg Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won't go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn't a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org ordr.c@fatsciencepodcast.com.Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

Originally aired in 2023, Molly Jacobson interviews Dr. Kim Agnew about the groundbreaking trials of Monepantel, a sheep dewormer repurposed as a potential treatment for canine lymphoma. Discover the science behind this innovative therapy, its potential to stabilize lymphoma, and how it compares to traditional treatments like chemotherapy and prednisone.  Key Topics:  What is Monepantel, and how was it discovered?  The mechanism behind Monepantel's ability to target cancer cells.  Early trial results: Quality of life and stability for dogs with B-cell lymphoma.  How Monepantel compares to prednisone and chemotherapy.  Insights into ongoing and future clinical trials.  How dog lovers can participate in studies.  Your Voice Matters!   If you have a question for our team, or if you want to share your own hopeful dog cancer story, we want to hear from you! Go to https://www.dogcancer.com/ask to submit your question or story, or call our Listener Line at +1 808-868-3200 to leave a question.   Related Videos:  https://www.youtube.com/watch?v=_92w6TTXM5c   https://www.youtube.com/watch?v=uAZrPM1X8ww   Related Links:  PharmAust Dog Lymphoma Clinical Trial: https://www.pharmaust.com/petdogtrial/  Chapters:  00:00 Introduction  00:30 Meet Dr. Kim Agnew and Monepantel Overview  01:15 The Origin of Monepantel: From Dewormer to Cancer Fighter  03:30 How Monepantel Targets Cancer Cells  07:00 Insights on Clinical Trials for Canine Lymphoma  09:30 Benefits of Monepantel: A Daily Pill for Dogs  12:00 Comparing Monepantel to Chemotherapy and Prednisone  14:45 Early Trial Results: Stabilizing Lymphoma in Dogs  18:30 Why Lymphoma Was Chosen for Trials  20:00 Potential for Treating Other Cancers in Dogs  23:15 How to Enroll Dogs in Clinical Trials  26:45 Side Effects and Safety of Monepantel  31:00 Future Trials and Research Goals  34:30 Closing Thoughts and Resources  33:55 Closing Remarks and Resources    Get to know Kim Agnew, BVSc: https://www.dogcancer.com/people/kim-agnew-bvsc/     For more details, articles, podcast episodes, and quality education, go to the episode page: https://www.dogcancer.com/podcast/   Learn more about your ad choices. Visit megaphone.fm/adchoices

Our heroes finally come to an end with their long awaited encounter with Prednisone and are in for a surprise when Flargelbuns alters the battlefield. As they look to escape the hope to stumble into better lands than they have been in. Check out our Linktree where we have Twitter, Facebook, Discord and Instagram! Come join in the and chat about your favorite moments with the cast!linktr.ee/thedhcastMusic credits: www.epidemicsound.com

Our heroes encounter much more than the illusion that Nox bargained for as they continue their altercation with Prednisone. Can they gain some needed information from this enounter and will they be able to survive long enough to use it?Check out our Linktree where we have Twitter, Facebook, Discord and Instagram! Come join in the and chat about your favorite moments with the cast!linktr.ee/thedhcastMusic credits: www.epidemicsound.com

Our heroes continue to push in battle against Prednisone while trying their best to protect their friend Flargelbuns. As they push to defeat this enemy they have searched so long for, can they save their friend in the process.Check out our Linktree where we have Twitter, Facebook, Discord and Instagram! Come join in the and chat about your favorite moments with the cast!linktr.ee/thedhcastMusic credits: www.epidemicsound.com

Prednisone

Our heroes finally confront their former companion Prednisone determined to put an end to him. They showed up prepared to fight but are caught off guard by an old friend. Can you put an end to Prednisone once and for all?Check out our Linktree where we have Twitter, Facebook, Discord and Instagram! Come join in the and chat about your favorite moments with the cast!linktr.ee/thedhcastMusic credits: www.epidemicsound.com

Dr. Jack Cush reviews the news, journal and regulatory reports from this week on RheumNow.com.  Interesting trends and results with prednisone in lupus, cannabis in RA and opioid deaths too!

Our heroes finally understand their past, and how their former friend has wronged them. They head back to Mucinex in order to formulate a plot to finally take down Prednisone one and for all.Check out our Linktree where we have Twitter, Facebook, Discord and Instagram! Come join in the and chat about your favorite moments with the cast!linktr.ee/thedhcastMusic credits: www.epidemicsound.com

Take a sneak peak at this month's Fertility & Sterility! Articles discussed this month are:   4:08 Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop  12:32 Impact of Prednisone on Vasectomy Reversal Outcomes (iPRED Study): Results from a Randomized, Controlled Clinical Trial 21:38 Triggering oocyte maturation in IVF treatment in normal responders: a systematic review and network meta-analysis 33:57 Parental Balanced Translocation Carriers do not have Decreased Usable Blastulation Rates or Live Birth Rates Compared to Infertile Controls  45:28 A re-look at the relevance of TSH and thyroid autoimmunity for pregnancy outcomes: Analyses of RCT data from PPCOS II and AMIGOS View Fertility and Sterility May 2025, Volume 123, Issue 5:  https://www.fertstert.org/issue/S0015-0282(25)X0004-2 View Fertility and Sterility at https://www.fertstert.org/

Today's sponsor is Freed AI! Freed's AI medical scribe listens, transcribes, and writes notes for you. Over 15,000 healthcare professionals use Freed and you should too! Learn more here! Prednisone is a commonly used medication for its antiinflammatory and immunosuppressive action. On this episode I discuss prednisone pharmacology, ADRs, and much more. In the episode, I discuss how prednisone affects the HPA system in the body. Cortisol production can be greatly impacted by long term use of prednisone. GI adverse effects can be problematic with oral prednisone which is why we often give this medication with food or milk. Hyperglycemia is a complication from the use of prednisone. I've commonly seen blood sugar spike by 50-100+ mg/dL due to this medication. Osteoporosis is a long term risk with the use of prednisone. Prednisone can also impact the benefits of vaccination. I discuss this in greater depth in the drug interactions portion of the podcast.

See all the Healthcasts at https://www.biobalancehealth.com/healthcast-blog In my Anti-Aging-Longevity practice, one of the complaints my new patients tell me about is the fact that their hair is thinning, falling out or changing to a brittle texture, as well as the fact that their hair is turning grey. Hair DOES get thinner, coarser, and greyer as we age!  That is a fact, and one I can't fully explain to you, except that it happens to everyone!  My philosophy is that each of us should work with what we have, and optimize it, as well as treat any condition that makes hair loss work instead of wishing and wishing we had the hair we did when we were 25! Accepting the fact that your hair gets thinner after 40 and working with the hair you have takes knowledge to determine what is normal and what is not. Some of the things that everyone should know before looking for the best path forward to healthy hair. Aging and Slower Hair Growth Low Growth Hormone Lack of Estradiol and T in women and lack of T in men Aging causes Growth Hormone (GH) to decrease, which slows the growth of hair, fingernails, bone.  Your hair falls out at the same rate as it did when you were young, but the growth slows which results in losing more hair than you replace which thins your hair! If you started your young life with fine, thin hair, then this difference between growth and loss of hair can make your hair very thin.  To get to the root of the problem (I apologize) increasing GH will make your hair grow a bit faster. Testosterone replacement and Estradiol replacement both increase the growth of GH. Both hormone replacements increase hair thickness. Testosterone has a second benefit.  Testosterone makes your scalp oiler, which in turn increases the longevity of your hair. At menopause the lack of these two hormones causes a big change in hair thickness. Loss of hair in specific areas—Balding Genetics Scarring alopecia Androgenic alopecia Extensions Dread-locks Balding and alopecia both cause a person to lose hair follicles, not just slow the rate of hair growth.  Balding usually is genetically determined, so look at the older members of your family to determine what is in your future.  This type of hair loss is very difficult to treat. 50% of men have some balding by age 50, and 1/3 of women experience it sometime in their lives.  Until recently there was nothing to stop this process or grow more hair in those areas, however both men and women can resurrect their hair follicles (if they haven't been gone too long) and make them grow with the TED hair restoration painless ultrasound treatment by Alma. Other options are Hans Weiman hair transplants or weaves, both of which are extremely expensive, don't necessarily look natural (President Biden and his son) and must be redone every couple of years. Women can just cover over the problem with a wig, but even that answer has drawbacks—they are hot and itchy until you get used to it. Women can also get extensions to make their hair look thicker, but it ruins the quality of the hair you have which in the long run causes even more hair loss from scarring of the scalp. Women of color have traditionally used tight braids, cornrowing or dreadlocks to control their hair.  This cultural process causes them to break their hair off at the scalp and damage the hair follicle from tension, which results in hair no longer growing in multiple areas of the scalp. Change in Hair Texture and Dryness At menopause for women and when men's testosterone gets very low, we notice a change in texture of our hair. The cuticle area that covers the hair shaft becomes fragile and stops protecting the hair shaft, so the texture becomes frizzy, and hair breaks causing a dull look similar to what my mother used to call a “birds nest”. Our scalps become dry, and the oil glands dry up with age and loss of sex hormones, so hair is dry and frizzy, making us look like we just stuck our fingers in a light switch.  You can read about many “natural remedies” but beyond taking collagen, Biotin and B vitamins most supplements don't work in a dramatic way that would be noticeable. The remedies for hair loss include all the following and you will have to do most of them to improve your aging hair! Hormone replacement of Estradiol and Testosterone Conditioners (which only work a little) Hair color which covers the shaft with pigment and strengthens hair Brazilian treatment that drives straightener into the hair shaft and seals it with heat. Take supplements of Collagen every morning Take methyl B12 and Biotin daily Stop bleaching your hair Eat a diet with healthy fats and protein Wash your hair every 2-3 days Take the fat soluble vitamins A.E.K,D If you are anemic take iron supplements Avoid statins if possible   Other medical causes of frizzy, broken hair can be found in low thyroid hormones which slows hair growth, decreases oil production, and results in brittle hair all over the head. Replacing your thyroid hormones and supplementing your iodine can overcome this obstacle. All medicine changes should be managed by your doctor. Many drugs cause hair loss, and you can't change some of them: Metoprolol or any Beta blocker Blood pressure medication Prednisone and all steroids Cancer treatments Anything that inhibits your B vitamins like some autoimmune diseases What can you do to fix what you can fix! Nutrition: Hair is protein; however hair requires oil (fat) to grow and be beautiful—a diet rich in protein, and healthy fats give you the building blocks to make healthy hair and skin. Add Vitamins of A/E/K/D, vitamin C, Multi Methyl B vitamins with methyl folate and Biotin because our diets aren't perfect!   Hair care: Get hair products without sulfides.  They break hair and make it weak!  Wash your hair as little as possible. Decrease the use of hot hair tools like flat irons.  Color your hair and or Brazilian it to make it stronger. Medications not to take are listed above. But the medications to take to help your hair are your sex hormones, Estradiol, Testosterone, and make sure your DHT doesn't get too high which can cause hair loss in the male pattern. You may need Finasteride or Minoxidil if you have male pattern hair loss. Sun damage is important to maintain your hair in sunny areas.  Wear a hat or scarf when outside and comb some conditioner through your hair at the pool to “cover your hair from sun damage”.   Summary: Now that you know the possible causes and treatments for hair loss, you can do everything possible up to seeking medical care, and then medical care may be necessary. Hair thinning is often familial and also due to our estradiol and testosterone hormones decreasing after 35-40 years of age. You may need a scalp biopsy from a Dermatologist if your hair loss is in patches or severe over a short period of time, which implies an autoimmune disease. When you see a doctor be prepared with a list of your hair products, your diet, a list of medicines and a timeline for your hair loss.  This preparation will get you the best treatment per doctor visit, and your doctor will appreciate not having to ask you all those questions!

Prednisone and cortisone shots can wreak havoc on blood sugar, but sometimes they're unavoidable. In this episode, I break down exactly what happens, why it happens, and how to handle it without losing your mind (or your blood sugar control). I'll share my own experience, tips for managing insulin resistance, and how to stay on top of your diabetes game!   Want the best blood sugars you've ever had while enjoying great food? Peep this: https://www.yourdiabetesinsider.com/coaching   RESOURCES: Download these FREE guides that will help you on your diabetes, nutrition, and exercise journey! https://www.yourdiabetesinsider.com/free-stuff Join our EXCLUSIVE Facebook group! https://www.facebook.com/groups/266766620895432 Watch my food breakdowns here → https://www.youtube.com/@yourdiabetesinsider   LET'S TALK! Instagram: @manoftzeel Tiktok: @manoftzeel  

All it takes is a small amount of oxidative stress to the eye's lens to develop a cataract. A healthy lens is composed of an organized protein called crystallin. When this tissue becomes damaged, it is not replaced. Glycation can damage the lens of the eye. It results from sugar connecting to a protein and then becoming stuck and unusable to the body. Steroids like Prednisone can also increase the risk of cataracts. Not all surgeries can eliminate cataracts, and they can come with complications. According to “The Cataract Cure” by Dr. Marios Kyriazis, there is a safe, effective remedy for cataracts. Carnosine is a unique compound that can penetrate the lens of the eye and help with cataracts. Carnosine is a potent antioxidant that can dissolve damaged proteins. It can also activate your own antioxidants. NAC (n-acetyl carnosine) eye drops are one of the best remedies for cataracts.In an experiment conducted at the Moscow Helmholtz Research Institute of Eye Diseases, scientists used NAC eyedrops at 1% concentration on rabbits. They found that NAC could reach the inner parts of the eye within 15 to 30 minutes. No side effects were reported during this experiment. The author concluded that NAC is a proposed eye treatment for eye disorders, including cataracts, glaucoma, corneal disorders, inflammation, and complications from diabetes.The same group of scientists who performed the rabbit studies also tested NAC on humans. They selected 49 volunteers with an average age of 65 who had established age-related cataracts. After 6 months, researchers found that:•41% of people presented a significant reduction of clouding in the lens•90% showed a gradual improvement in vision•89% showed up to a 100% improvement in sensitivity to glare NAC for cataracts must be used for at least 3 to 5 months. Antioxidants such as those found in onions, egg yolks, leafy greens, and grass-fed red meat can protect you against cataracts.Vitamin A is vital for eye health and can be found in cod liver oil and grass-fed liver. B vitamins, especially B2, B6, and folate, are also essential. BOOK LINK: https://www.amazon.com/Cataract-Cure-... DATA:https://pmc.ncbi.nlm.nih.gov/articles...https://pubmed.ncbi.nlm.nih.gov/12001...https://pubmed.ncbi.nlm.nih.gov/26084...

Mike is an IT Infrastructure Manager in Las Vegas, and he's coming up on 1 year of Carnivore in March. He was diagnosed with Mixed Connective Tissue disorder in 2016, and has in the past been on Methotrexate, Prednisone, Enbrel, and Rinvoq. MCTD consists of elements of Sjogens, Rheumatoid Arthritis, and Lupus. Since going Carnivore, the only non-Carnivore thing he still uses that helps is Qunol Tumeric and Ginger gummies to help with inflammation. He has lost 50 pounds, his symptoms are gone until he eats something he shouldn't, and he has more energy and his hands have stopped hurting. Timestamps: 00:00 Trailer 01:18 Introduction 07:49 Sedentary job, unhealthy diet 08:58 Loss of basic functionality 13:34 Keto diet success and weight loss 16:06 Beef-centric meal prep routine 18:35 Rib eye diet cures symptoms 22:30 Couple's weight loss success 24:40 Prioritizing quality meats over extras 29:38 Diet's role in rheumatism neglected 31:43 Air fried rib eyes & snacks 35:06 Curbing cravings with ribeye 38:15 Revitalizing lives through dietary change 40:45 Easing into a carnivore diet 43:10 Mindful eating on vacation 46:34 Where to find Mike Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

Recommended Apple Cider Vinegar: https://www.fairchildsvinegar.com/ Most people are familiar with the more popular benefits of apple cider vinegar, including the following: •Supports digestion •Decreases bloating •Improves indigestion and acid reflux •Supports healthy blood sugar levels •Helps make insulin more sensitive •Decreases a fatty liver •Decreases inflammation Both good bacteria and bad bacteria can go into a dormant state. Microbes in a dormant state are protected from many environmental stresses and chemicals, especially antibiotics. Dormant microbes can survive for decades or even thousands of years! A change in environment, like a change in pH, can wake good bacteria or cause them to go dormant. Most good bacteria thrive in an acidic environment. Apple cider vinegar acidifies the environment for good microbes. Things like kombucha, pickle juice, sauerkraut, and kimchi have similar effects. Certain microbes create butyrate, which helps with insulin resistance. These microbes thrive in an acidic environment. We have a synergistic relationship with the microbes in our gut. We provide a home, and they provide immune protection, help with digestion, vitamin production, and more. By making their environment more acidic, you help activate them. H. pylori releases ammonia, which alkalizes the stomach acid. This allows it to do its damage, causing ulcers in the stomach and small intestine. C. diff, E. coli, and salmonella go into a state of dormancy when the pH drops below 6. When your immune system is suppressed, bad bacteria can come out of dormancy. Antibiotics, stress, Prednisone, and vitamin D deficiency can all suppress the immune system and activate pathogenic microbes. Adequate vitamin D in amounts of at least 10,000 IU daily may help keep pathogenic microbes in remission. Try drinking 1 tablespoon of apple cider vinegar in a glass of water every evening with a straw to support your beneficial microbes. Fairchild's Apple Cider Vinegar is an excellent option.

Today, we're going to take a look at the underlying cause of autoimmune disease. Your immune system has two parts: the innate immune system that you're born with and the acquired immune system that's created through a series of infections. Over time, the acquired immune system becomes stronger and offers protection against infection. The innate immune system is not the problem when it comes to autoimmune diseases. Autoimmune disorders typically involve problems with the T-regulatory cells or T-cells. Also called suppressor T-cells, these cells are the peacemakers of the immune system and stop the immune reaction when the job is done. Prednisone, the synthetic version of cortisol, is commonly used as a treatment for autoimmune diseases. Both prednisone and vitamin D have reduce inflammation, but Vitamin D empowers and enhances the immune system. Prednisone suppresses the innate and the acquired immune systems. Vitamin D shifts the immune system to increase the T-cells. Inflammatory TH1 and TH17 cells are usually too high when someone has an autoimmune disease. Vitamin D suppresses both of these cells, reducing inflammation. Prednisone raises your blood glucose levels while vitamin D does not. Vitamin D enhances the cells that makes insulin and helps to regulate your blood sugars. Prednisone can break down your bone, leading to osteoporosis. Vitamin D helps you absorb calcium and supports bone remineralization. The thymus gland makes T-cells. As we age, the thymus gland deteriorates and our immune systems decline. Vitamin D slows down this process, but you need larger, therapeutic doses. Vitamin D does not work without the cofactors magnesium, vitamin K2, and zinc. Dr. Coimbra of Brazil created a protocol that involves increasing vitamin D to penetrate any resistance. This lowers the parathyroid hormone which means that vitamin D levels have significantly increased. DATA: https://www.coimbraprotocol.com/gener... https://ajcn.nutrition.org/article/S0... http://www.vitamindprotocol.com/vitam...

Let's talk about the health benefits of turmeric. One study found that curcumin was just as effective as ibuprofen at reducing pain from arthritis without side effects! It's also shown to be as effective as aspirin. Another study showed that curcumin had comparable results to Prednisone in reducing inflammation for rheumatoid arthritis, asthma, and IBS. It has also been shown to produce antidepressant effects similar to Prozac and Zoloft. Curcumin has anti-diabetic properties and effects similar to Metformin. It also has anticoagulant properties similar to aspirin and Warfarin. Research has shown that curcumin has benefits similar to statins and can help reduce LDL cholesterol and triglycerides. One study compared curcumin to 5-fluorouracil, a chemotherapy drug. Turmeric has been shown to be as effective as anti-inflammatory drugs, especially for irritable bowel disease and digestive problems. It may also help reduce blood pressure and inhibit pathogens, especially fungi. To prepare turmeric water, combine ½ teaspoon of turmeric powder, a pinch of black pepper, and half of a lemon in a glass of warm water. To prepare golden milk, combine ½ teaspoon of turmeric, ¼ teaspoon of cinnamon, and a pinch of black pepper in a cup of milk or coconut milk. Heat the mixture and remove from heat just before it comes to a boil. You can also add turmeric to a smoothie with berries and kefir. If you have a cough, try drinking a cup of hot water with a teaspoon of turmeric and a tablespoon of raw honey. DATA: https://www.ncbi.nlm.nih.gov/pmc/arti... https://pubmed.ncbi.nlm.nih.gov/10404... https://pubmed.ncbi.nlm.nih.gov/23832... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.sciencedirect.com/science... https://www.ncbi.nlm.nih.gov/pmc/arti... https://www.sciencedirect.com/science... https://pubmed.ncbi.nlm.nih.gov/17101... https://pubmed.ncbi.nlm.nih.gov/23142... https://www.ncbi.nlm.nih.gov/pmc/arti...

DOWNLOAD THE WALLET CUTOUT CARD HERE: https://bit.ly/3TsJJ8s In this podcast, I'm going to tell you how to reshape your face naturally and get rid of a moon face. One of the most common symptoms of Cushing's syndrome is a “moon face.” Cushing's syndrome is characterized by high levels of the stress hormone cortisol. Chronic high cortisol over a period of time can cause fat face syndrome. It can also be caused by the drug Prednisone. Cortisol can redistribute fat to different parts of the body, causing you to store fat in the face and the midsection. Over time, it can cause a hump on the back, red cheeks, thinner legs, and weak muscles in the legs and buttocks. Your cholesterol and lipids may rise, and you'll start losing potassium and retaining sodium. This sends your blood pressure straight up, vitamin D levels decrease, and your immune system suffers. Cortisol indirectly causes a puffy face by breaking down protein and turning it into glucose. This spikes insulin, a fat-storing hormone. In the presence of too much insulin, you won't be able to lose fat. Carbohydrates, frequent eating, seed oils, nutrient deficiencies, stress, overexercising, and certain medications also trigger insulin. Try these 5 tips to reshape your face. 1. Eat less frequently Cut out the snacks between the meals and do intermittent fasting. This forces your body to use body fat as fuel between meals. 2. Change your diet Cut down your carb intake, specifically avoiding sugar and starch. Print my card cutout that shows you the ingredients to avoid! 3. Increase protein Look for high-quality grass-fed meat such as beef, lamb, or goat. 4. Lower stress levels Go for long walks, exercise, and do physical work. Avoid excessive phone use. 5. Try to get extra sleep Make sure you're getting enough sleep. Even if you wake up early, try to go back to sleep if possible!

Today, I'm going to share a few natural sciatica pain remedies! The sciatic nerve is the longest and largest nerve in the body. It extends from the lower back, down the back of the leg, to the bottom of the foot. Surgery for sciatica can cause side effects like failed back surgery syndrome. Because 90% of sciatica pain will often resolve by itself, invasive procedures are best saved as a last resort. Sciatic pain often gets worse in the winter, which would explain why vitamin D deficiency is a major contributor. If you're dealing with inflammation, you need high amounts of vitamin D daily. Vitamin D is a potent anti-inflammatory and works similarly to Prednisone without the side effects. It helps to repair the nerves, disc, connective tissue, and muscles involved with sciatica. Magnesium deficiency can also contribute to sciatica because it's essential for keeping your muscles relaxed. You also need adequate magnesium for vitamin D to work in the body. Vitamin B12 is involved with several aspects of the nervous system and can cause numbness, tingling, and burning pain if you're deficient. It's highly anti-inflammatory, and a deficiency can also contribute to sciatica. Most people don't get enough sun, so unless you're taking 10,000 IU of vitamin D each day, you could end up deficient. If you have sciatica, try upping your dose of vitamin D3 to 20,000 to 30,000 IU daily. Around 800 mg of magnesium each day can be beneficial for sciatica. Sunflower seeds, pumpkin seeds, chocolate, almonds, leafy greens, bone broth, and spinach are good food sources of magnesium. Red meat and other animal products provide plenty of vitamin B12. Try these simple sciatica exercises focused on stretching the fascia to say goodbye to your sciatic nerve pain!

On this episode of the Real Life Pharmacology podcast, I continue my education on the top 200 drugs. Raloxifene, prednisone, phenytoin, fish oil, and ezetimibe are covered in this podcast episode. Prednisone is a corticosteroid that may cause hyperglycemia, insomnia, GI upset, osteoporosis, HPA suppression, and hypertension as primary adverse effects. Raloxifene is classified as a SERM and can be used for osteoporosis and breast cancer. DVT and hot flashes are significant adverse effect concerns. Fish oil (Lovaza) is used to reduce triglycerides. Elevated triglycerides can increase the risk of pancreatitis. Ezetimibe inhibits the absorption of cholesterol through the gut. It lowers LDL but not to the extent of statins. Phenytoin is a narrow therapeutic index medication (NTI) that is used as an anticonvulsant. Ataxia, confusion, GI upset, and vertical nystagmus are potential signs of toxicity.

Episode 2496 - On this Monday's show Vinnie Tortorich and Anna Vocino chat about Vinnie's cancer protocol, dealing with insurance companies, and more. https://vinnietortorich.com/2024/06/dealing-with-insurance-episode-2496 PLEASE SUPPORT OUR SPONSORS YOU CAN WATCH ALL THE PODCAST EPISODES ON YOUTUBE - Dealing With Insurance Vinnie is grateful for all the well-wishes from his followers/supporters. (2:00) He gives an update about his cancer treatment, and he also wants to discuss advocating for yourself. (3:00) He advocated for himself regarding his medications. He is not against doctors, he but emphasizes the importance of communicating with them. (15:00) You don't have to get adversarial, just be sure to have the conversations and advocate for yourself. Anna was on Prednisone recently and it helped her, but she was miserable on it. (17:00) They discuss insurance; you pay for insurance to ensure you get the care you need when needed. (21:30) Vinnie had an injection that cost $16,000! He explains where there was a discrepancy between the hospital and the pharmacy Anna shares her experience with insurance regarding her recent hysterectomy. (30:00) There are insurance companies that fight patients' insurance until the patients have to file bankruptcy. Anna tells a story about a wine tasting, a prank, and a celebrity or two. (47:00) The “Dirty Keto” documentary landing page should be up by May 30th. You can go to Vinnie's website and enter your email to get notified. When it comes out, make sure you watch and rate it. There's a new NSNG® Foods promo code you can use! (53:00) The promo code ONLY works on the NSNG® Foods website, NOT on Amazon. Anna's upcoming Eat Happy Italian book is on the way. You can go to: —upload your receipt and get bonus content.  You can preorder it from . [the_ad id="20253"] PURCHASE BEYOND IMPOSSIBLE (2022) The documentary launched on January 11! Order it TODAY! This is Vinnie's third documentary in just over three years. Get it now on Apple TV (iTunes) and/or Amazon Video! Link to the film on Apple TV (iTunes):  Then, Share this link with friends, too! It's also now available on Amazon (the USA only for now)!  Visit my new Documentaries HQ to find my films everywhere: REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: Then, please share my fact-based, health-focused documentary series with your friends and family. The more views, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter!