Podcasts about s1934

GUEST: John Ronald, London (ON, Canada)Welcome back!  It has been a while but are back with a bang, having our good friend John Ronald from The Robarts Research Institute in London, Ontario as our guest. John's group combines advances in molecular and synthetic biology with a multimodal imaging perspective to build new tools for early detection and treatment of cancer, as well as non-invasive monitoring of cell, gene and genome therapies. One of John's passions is gene reporter imaging, which is also the main focus of this edition. The paper up for discussion comes from Cynthia Dunbar's lab at NIH, Bethesda which was recently published in Cell Stem Cell. We discover their approach to non-invasively follow engraftment and maturation of pluripotent stem cells in rhesus macaques with myocardial infarctions, discuss some of the technicalities of engineering autologous cells, and fall in love with the beautiful RNAScope images that are presented. We discuss what makes a good imaging reporter, why one size doesn't always fit all, and a future where not just cells, but activation states can be imaged. Along the way, John also shares advices received from the wonderful Sanjiv Sam Gambhir on how to improve the chances of getting your grants funded and that supposedly crazy ideas should not be discarded... they might even lead to high impact publications.And of course, true to our tradition, we enjoy a special cocktail. For this edition the “Angry Canadian”, obviously. For the curious listeners: a good measure of Whisky, 2 tablespoons of fine Canadian Maple syrup, a few drops of bitters and 1 teaspoon lemon juice, then top up with soda water.Selected Publication: Lin Y, Sato N, Hong S, Nakamura K, Ferrante EA, Yu ZX, Chen MY, Nakamura DS, Yang X, Clevenger RR, Hunt TJ, Taylor JL, Jeffries KR, Keeran KJ, Neidig LE, Mehta A, Schwartzbeck R, Yu SJ, Kelly C, Navarengom K, Takeda K, Adler SS, Choyke PL, Zou J, Murry CE, Boehm M, Dunbar CE. Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques. Cell Stem Cell. 2024 Jul 5;31(7):974-988.e5. doi: 10.1016/j.stem.2024.05.005. Epub 2024 Jun 5. PMID: 38843830; PMCID: PMC11227404. https://www.cell.com/cell-stem-cell/abstract/S1934-5909(24)00182-6Further information on the European Society for Molecular Imaging:https://e-smi.eu/Contact: office@e-smi.eu 

If you are doing a fast, chances are you've looked at your coffee in the morning and thought, “Is this technically breaking my fast?”. In this video, I break down what breaks a fast, and what you can consume to get nutrients in while still abstaining from food. Drinking things like broth and coffee can reduce your hunger levels. This means if you're having hunger pains while trying to lose weight, you can have a delicious drink that will take your mind off of the temptation of food. I also recommend collagen, which not only tastes good and eliminates hunger, but also provides essential amino acids that your body needs to stay strong. If you're looking for a way to get nutrients in and make water taste better in a fast, check out my greens powder here: https://store.drlivingood.com/products/livingood-daily-greens-berry You can also try my collagen powder, which is full of amino acids: https://store.drlivingood.com/products/livingood-daily-collagen-protein-vanilla If you're drinking water during a fast, but aren't absorbing it, you're probably not getting enough electrolytes. Check out my electrolyte powder here: https://store.drlivingood.com/products/energyze Research: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(14)00151-9 This episode was extracted from Dr. Livingood's YouTube channel. Click here to subscribe: https://bit.ly/3xUx8kl Or, click here to view the original video and any links referenced in this podcast: https://www.youtube.com/watch?v=mTMje551j4c&t=206s

Jonathan Brassard obtained his Bachelor's degree in Chemical Engineering at Université Laval followed by a Master's in Bioengineering in Switzerland. Two years ago, he joined Prof. Corinne Hoesli at Mcgill University in Biological and Biomedical Engineering to work on combining stem cell biology and device engineering to treat type 1 diabetes. When he's not in the lab tending to his very needy stem cells, you can find him hiking, climbing or taking pictures of cute animals he encounters during his outdoor adventures! Tune in for answers to questions like... How did we discover stem cells and how are they used in bioengineering research? How do we create and manipulate miniature organs in the lab? What is the cutting edge in the treatment and management of diabetes? Where does the future of bioengineering look like? and many more! Topics & Concepts Bioengineering, Chemistry & Medicine Stem Cells Pluri- & Multi-potency Progenitor Cells Genetics & Environment Differentiation & Self-Organization Morphogenesis Organoids Personalized Medicine In Vitro vs. In Vivo Bioprinting Freedom & Constraint The Pancreas Exocrine & Endocrine Islets of Langerhans Alpha, Beta & Delta Cells Artificial Pancrease Insulin & Glucose Transplantation & Cadaveric Donors The Immune System Pouches & Membranes Collaboration Resources Bioprinting, Stem Cells & Organoids https://www.technologynetworks.com/tn/news/researchers-develop-new-method-to-print-tiny-functional-organs-340763 Self-Organization of Stem Cells https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30209-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590919302097%3Fshowall%3Dtrue#secsectitle0010 Contact Twitter: @Brassardjon Facebook: facebook.com/jonathan.brassard.77 --- Send in a voice message: https://anchor.fm/abstractcast/message

In this episode, we’ll hear about why you might want to be skeptical of raw water, with Gail Teitzel, Editor of Trends in Microbiology (00:00); how brain chemistry might change in mice as a result of social isolation, with David Anderson, Cell (07:45); and what’s unusual about neurons in people with severe obesity, with Dhruv Sareen, Cell Stem Cell (17:10). Then, stay tuned for our monthly news roundup, including using MRI to predict risk tolerance; rethinking what we know about genetics, sugar, and weight gain; and how the sweet potato arrived in Polynesia (26:13).

Hva er egentlig fasting, og kan det hende at det faktisk er godt for oss å gå uten mat i perioder? I denne episoden forsøker vi å gå inn i noe av den forskningen som finnes om tema, og kanskje bli kvitt et par vrangforestillinger flesteparten av oss nok har om fasting. Vi starter med en kort gjennomgang av autofagi, som er den prosessen som årets nobelprisvinner i medisin, Yoshinuri Ohumi, har forsket på. Det skal vise seg at årets pris har mer enn litt å gjøre med tema for vår juleepisode.  Vi har også vært ute på gata og spurt folk om dette tema, så før selve episoden begynner får dere noen smakebiter på hva folk tenker om det å gå uten mat.  Gi oss gjerne en tilbakemelding på denne og andre episoder, enten på Itunes eller vår side på Facebook. Del oss også gjerne med andre, om du synes dette er verdt å høre på.  God jul alle sammen, vi ser frem til mer podcastproduksjon i 2017! Alt godt!    Kilder vi har brukt i arbeidet med denne episoden: Her finner dere hele foredraget til Jason Fung som vi spilte et par utdrag fra: 'Therapeutic Fasting - Solving the Two-Compartment Problem': https://www.youtube.com/watch?v=tIuj-oMN-Fk Faste som en naturlig respons på infeksjon. Forskjellige effekter på virus og bakterier: https://www.ncbi.nlm.nih.gov/pubmed/27610573 Faste ved sykdom, evolusjonært perspektiv, bruker begrepet sickness-associated anorexia (SAA) https://www.ncbi.nlm.nih.gov/m/pubmed/27445441/ Intervju med Beth Levine, som leder teamet som i 1999 viste hvordan autofagi spiller en viktig rolle i kroppens naturlige bekjempelse av kreft og flere andre sykdommer. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973115/ Korte fasteperioder øker lysosomaktivitet i hjerne: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/ Leder i siste Tidsskrift for norsk legeforening, (6.des 2016) om autofagi:  http://tidsskriftet.no/2016/12/leder/selvspising-forlenger-livet Artikkel i Cell som redegjør for noe av den nyere forskning på fasting og mulige effekter på aldring og kreft http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(14)00203-3 Fastetradisjoner før jul i den ortodokse kirken: http://www.religion.dk/synspunkt/julefaste-sk%C3%A6rper-gl%C3%A6den Artikkel fra 1973 som beskriver faste som varte i 382 dager: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495396/pdf/postmedj00315-0056.pdf George Cahill, oppsummerende artikkel fra 2006 om forskning på faste (“Were it not for the β-hydroxybutyrate and acetoacetate providing brain fuel, we Homo sapiens might not be here!”) http://ltc-ead.nutes.ufrj.br/constructore/objetos/artigo%206%20Cahill%202006%20annu%20rev.%20nutr.%20Prof%20Juliana.pdf George Cahill, Richard Veech, “Ketoacids? Good medicine?” http://okdentalwellness.com/uploads/3-Superfuel.pdf Studie på effekten av fasting under Ramadan på personer med kardiovaskulær risiko (ikke publisert ennå så vidt vi kan se, men morsomt at slik gjøres). https://clinicaltrials.gov/ct2/show/NCT02720133?term=fasting&rank=19 Episode 259 av This American Life, “Promised Land” har et innslag om fasting. Det er egentlig irriterende mye fokus på det åndelige aspektet, hvor det ventes et slags mystisk øyeblikk hvor fasten skal gi ny innsikt eller noe i den dur, og det er ikke så rart reporteren blir skuffet. Men innslaget har i det minste det positive bidraget at det viser hvordan en uerfaren, fasteskeptisk person klarer å gjennomføre en temmelig lang faste uten særlig problem. https://www.thisamericanlife.org/radio-archives/episode/259/promised-land Radiolab-episoden som tar for seg sult og sykdomsforekomster i nordsvensk by: http://www.radiolab.org/story/251885-you-are-what-your-grandpa-eats/ “The enigmatic membrane”, veldig god artikkel om autofagi, fra The Scientist http://www.the-scientist.com/?articles.view/articleNo/31626/title/The-Enigmatic-Membrane/

El paper de Laura --> Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation --> http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30252-1.pdf Zika situation report de la WHO/OMS en el día en el que grabo este podcast El paper de Laura --> Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation --> http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30252-1.pdf Zika situation report de la WHO/OMS en el día en el que grabo este podcast [25 August 2016] Key updates Countries and territories reporting mosquito-borne Zika virus infections for the first time in the past week: None Countries and territories reporting microcephaly and other central nervous system (CNS) malformations potentially associated with Zika virus infection for the first time in the past week: Costa Rica, Dominican Republic and Haiti Countries and territories reporting Guillain-Barré syndrome (GBS) cases associated with Zika virus infection for the first time in the past week: None The 2016 Summer Olympics held in Rio de Janeiro ended on 21 August. From the reports WHO received from national health authorities, there have so far been no laboratory confirmed cases of Zika virus in anyone associated with the Olympics. Operational measures updates from the WHO Regional Office for the Americas: WHO provided technical advice on integrated vector management in Puerto Rico, molecular diagnosis of Zika in the Bahamas, and clinical management of GBS in the context of the Zika emergency in Chile. http://www.who.int/emergencies/zika-virus/situation-report/25-august-2016/en/ El paper que menciono que se ha vuelto a hacer con ratas en lugar de ratones y ha salvado la memoria a largo plazo de los runners --> Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory http://www.jneurosci.org/content/36/31/8112.abstract Este contenido es gratis y sólo te pido que, si te ha gustado, entretenido, iluminado de algún modo, lo compartas en tus redes y nos valores en tu plataforma de pódcast favorita. Gracias ;)

El paper de Laura --> Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation --> http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30252-1.pdf Zika situation report de la WHO/OMS en el día en el que grabo este podcast [25 August 2016] Key updates Countries and territories reporting mosquito-borne Zika virus infections for the first time in the past week: None Countries and territories reporting microcephaly and other central nervous system (CNS) malformations potentially associated with Zika virus infection for the first time in the past week: Costa Rica, Dominican Republic and Haiti Countries and territories reporting Guillain-Barré syndrome (GBS) cases associated with Zika virus infection for the first time in the past week: None The 2016 Summer Olympics held in Rio de Janeiro ended on 21 August. From the reports WHO received from national health authorities, there have so far been no laboratory confirmed cases of Zika virus in anyone associated with the Olympics. Operational measures updates from the WHO Regional Office for the Americas: WHO provided technical advice on integrated vector management in Puerto Rico, molecular diagnosis of Zika in the Bahamas, and clinical management of GBS in the context of the Zika emergency in Chile. http://www.who.int/emergencies/zika-virus/situation-report/25-august-2016/en/ El paper que menciono que se ha vuelto a hacer con ratas en lugar de ratones y ha salvado la memoria a largo plazo de los runners --> Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory http://www.jneurosci.org/content/36/31/8112.abstract El paper de Laura --> Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation --> http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30252-1.pdf Zika situation report de la WHO/OMS en el día en el que grabo este podcast [25 August 2016] Key updates Countries and territories reporting mosquito-borne Zika virus infections for the first time in the past week: None Countries and territories reporting microcephaly and other central nervous system (CNS) malformations potentially associated with Zika virus infection for the first time in the past week: Costa Rica, Dominican Republic and Haiti Countries and territories reporting Guillain-Barré syndrome (GBS) cases associated with Zika virus infection for the first time in the past week: None The 2016 Summer Olympics held in Rio de Janeiro ended on 21 August. From the reports WHO received from national health authorities, there have so far been no laboratory confirmed cases of Zika virus in anyone associated with the Olympics. Operational measures updates from the WHO Regional Office for the Americas: WHO provided technical advice on integrated vector management in Puerto Rico, molecular diagnosis of Zika in the Bahamas, and clinical management of GBS in the context of the Zika emergency in Chile. http://www.who.int/emergencies/zika-virus/situation-report/25-august-2016/en/ El paper que menciono que se ha vuelto a hacer con ratas en lugar de ratones y ha salvado la memoria a largo plazo de los runners --> Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory http://www.jneurosci.org/content/36/31/8112.abstract Este contenido es gratis y sólo te pido que, si te ha gustado, entretenido, iluminado de algún modo, lo compartas en tus redes y nos valores en tu plataforma de pódcast favorita. Gracias ;)

In this edition, we’ll discuss the controversy over direct-to-consumer stem cell sales, with Leigh Turner and Paul Knoepfler, Cell Stem Cell (00:00); how building design can impact your respiratory health, with Jordan Peccia, Trends in Microbiology (10:10); the complex link between Alzheimer’s disease and the immune system, with Morgan Sheng and Felix Yeh, Neuron (16:15); and an eye-opening look at the risky business of experimenting on yourself (25:30).

In this edition, we learn how the Zika virus affects fetal development, with Guo-li Ming, Hongjun Song, and Hengli Tang, Cell Stem Cell (00:00), how fungi may be used to create batteries, with Geoffrey Gadd, Current Biology (5:45), how organs can be mimicked with chip technology, with Donald Ingber, Cell (11:40), and a personal story about travel and the Zika threat, with Simanta Buck (18:05). Plus much more!

How stem cells can be used to model and understand heart disease, with Joseph Wu (00:00 Cell Stem Cell). How clinicians consider the risk of heart-related side effects when treating cancer patients with chemotherapy drugs, with Michael Ewer (11:20 Trends in Pharmacological Sciences), plus a round-up of great science stories from Cell Press this month! (20:52).