Podcasts about ipsc

3 Takeaways from my conversation with Deniz Kent, CEO of Prolific Machines: 1. Moonshot thinking starts with a real problem. Deniz saw conflict over resources and asked: what if cells could make everything we need? That question built a company. 2. The best technology has the lowest cost AND highest quality. When those two things align — adoption follows. Every time. 3. Assemble people smarter than you. Deniz conceived the idea. Then got out of the way and hired scientists better than himself. That's leadership.   --- About Deniz Kent, PhD • Co-Founder & CEO, Prolific Machines (Oct 2020–Present). Conceived the core technology, built the leadership team, and secured $90 M+ from top-tier investors including Breakthrough Energy Ventures, In-Q-Tel, Ki Tua Fund, Mayfield. • GSK, Scientist (Sep 2014–Sep 2015). Developed in-vitro monocyte-derived dendritic cell models to investigate tolerogenic receptors. • University of Bristol, Tumour Immunology Researcher (Sep 2014–Sep 2016). Investigated adenosinemediated suppression of CD8⁺ T cells. • UMass Medical School, Visiting Scholar (Jun 2019–Dec 2019). Advanced collaborative research on hepatic cell models. Domain expertise & credentials • Conceived the vision for optogenetic bio- manufacturing and moved to the U.S. to co-found and lead Prolific Machines. • PhD, Centre for Stem Cells & Regenerative Medicine, King's College London ('16–'20). Co-discovered a novel human liver stem cell population (Segal & Kent et al., Nat Comm 2019). Led first high-throughput small-molecule screen on iPSC-derived hepatocytes—identifying 7 novel hits, 2 under patent. • Technical specialties include optogenetics, single-cell RNAseq, iPSC differentiation, AI-driven bioprocess optimization Notable awards & recognitions • Deniz is a member of Founder's Pledge and was appointed to the World Economic Forum's Bioeconomy Initiative. Connect with Jon Dwoskin: Twitter: @jdwoskin Facebook: https://www.facebook.com/jonathan.dwoskin Instagram: https://www.instagram.com/thejondwoskinexperience/ Website: https://jondwoskin.com/LinkedIn: https://www.linkedin.com/in/jondwoskin/ Email: jon@jondwoskin.com Get Jon's Book: The Think Big Movement: Grow your business big. Very Big! Connect with Deniz Kent, PhD: Website: https://www.prolific-machines.com  X: https://x.com/prolificmachine   LinkedIn: https://www.linkedin.com/company/prolific-machines    *E - explicit language may be used in this podcast.

Guest: Dr. Abdullah Khan is an Associate Professor of Tissue Engineering at the University of Oxford and a Group Leader at the MRC Weatherall Institute of Molecular Medicine. He discusses how his lab engineers complex human tissue models to study the cellular interactions that drive development, aging, and disease. He also explores how multi-organoid systems can model interactions between tissues such as the bone marrow and heart, and how these platforms could advance disease modeling, drug discovery, and preclinical research. Featured Products and Resources: Get a free wallchart on the derivation and applications of hPSCs. Subscribe to ESC & iPSC News to receive all of the latest research, news, jobs, and events in ESC & iPSC research. The Stem Cell Science Round Up Rescuing hPSC Differentiation – A chemical chromatin restoration approach reverses differentiation defects in human pluripotent stem cells, restoring their ability to generate diverse cell types and brain organoids. A Tumor Organoid Atlas – Patient-derived tumor organoids reveal cancer-specific gene dependencies and therapeutic vulnerabilities, providing a resource for advancing precision oncology. Mapping New Cancer Vulnerabilities – CRISPR screening of organoids and spheroids expands the Cancer Dependency Map, revealing cancer vulnerabilities and molecular subtypes missed by traditional cell lines. Building Better Cancer Models – A large collection of next-generation cancer models captures much of the genetic and epigenetic diversity of patient tumors, creating a resource for studying cancer biology and treatment response. Modeling Heart Valve Disease – Human iPSC-derived valve assembloid models heart valve development and reveals how mechanical forces and fluid flow shape valve formation and disease. Heart Valves in the Lab – Stem cell-derived 3D heart valve tissues recapitulate key features of valve maturation and provide a human platform for studying inflammation and calcific valve disease. Photo Reference: Courtesy of Dr. Abdullah Khan. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Double Tap Double Tap - Ep 474 August 10, 2026 Presented by This episode of Double Tap is brought to you by: Foxtrot Mike (Code: WLSISLIFE) C&G Holsters (Code: WLSISLIFE) Gideon Optics (Code: WLSISLIFE) Midwest Industries (Code: WLSISLIFE) Blue Alpha Giveaways!! GAW   Text Dear WLS or Reviews +1 743 500 2171 Public   Show Titles   Dear WLS Question from Ben B from Kansas Ben B (TLDR from last week: Bought a Bergara B14-HMR that wouldn't group and had a crooked-looking scope. After replacing the rail, rings, and checking the scope, a gunsmith finally discovered the rifle's mounting holes were drilled at a 45° angle from the factory. The manufacturing defect that made proper alignment impossible.)Continuation of the story from where it cut off last week- We looked in there and about half the threaded hole in the receiver was visible through the rail. Well shit… We tried a different rail and it was the same. I decided to contact Bergara to see if they would fix it. I started a warranty case with them and they sent an RMA form and asked me to ship the rifle to them. I sent it over and assumed that everything would be straightened out. After several weeks with zero updates, I called and asked for some kind of information. I even gave them exact instructions on how to replicate the problem. They said they would update me when they got it into their system and when they got started on the inspections. After they had it for a month they finally shipped it back and their conclusion was that the rifle was in spec. About a million emails later and both sides being stubborn, I gave up. Obviously they weren't going to fix it and I was at my wit's end. I brought it back to the gunsmith and had him drill and re tap the receiver holes to a big enough size to line it up. In spec my ass. Ever since then the Bergara name has left a bad taste in my mouth. I'm not really on social media and don't know how to get through how bad of an experience I had with them because I think people need to know. I am sorry for the long story but I already left a lot of details out. Just remember you asked for this Shawn Question from Bama Chris I know this will take forever And I'm expecting And answer sometime in about 2029 … Just found out the other day from Savage that my current credit card provider that used to be discover card and is now Capital One is a bunch of anti-gun Cucks … I need to cancel My over 20-year account With this credit card company Actually I have two accounts Cancel them both And find a credit card company That is 2a friendly Any suggestions… This is for Customer-Based Credit line Not Business related Processing. Wouldn't man if it was A car that instead of me getting cash back All of that went towards donations Second Amendment Foundation or other Friendly OrganizationsThanks Five squares second call defense is awesome High Point rules and Jeremy is my spirit animal Question from Anonymous Coward from Kentucky Question from Coward with anonymity from Virginia. I know you have probably said it a hundred times, but I have no experience with 3d printing. What is the best starter printer that's user friendly and capable. Great show, thanks! Question from Peter J from WA Peter J from WA, Dear WLS, I'm interested in either buying a factory ported pistol or having one I own custom ported. Is it really worth the hype? Im debating on either getting a CZ ported P10c or getting my CZ P10F ported. Use case would be more for range but would carry the ported p10c since I carry a non ported one currently. I more than with do what Jeremy or Nick tell me what to do. Thanks Question from eTexNerd from Texas Dear wls, from eTexNerdFirst a big Ole howdy from the upper east side of Texas to Tom Bowers! Question: once Bowers group is running production in Texas, won't I be able to buy his suppressors without federal redtape? I think Texas passed a law to allow intrastate transfer of suppressots made within Texas. I'm a little vague on the legal details but figure Tom being in the industry would know more. Maybe the cartoon savage legal hawk can explain this too. VIVA LA TEJAS! WINNER Question from Anonymous Coward from Texas Dear WLS. from Organiv Nut Milk Producer,Last week I learned about a new trend called ballmaxxing. Assuming one wished to take up this hobby, would you recommend switching from appendix carry to SOB? Gun Industry News Inside Safariland Derya Arms Derya MAX Cadre Derya Arms (Jacksonville, FL) has released the Derya MAX, a proprietary magazine-fed 12-gauge semiautomatic shotgun developed over three years with input from champion-level competitive shooters. It uses a self-cleaning curved gas piston that reliably cycles loads from 7/8 oz target shells to 3″ magnums, incorporates a proprietary MAX Brake and double-buffered recoil system to minimize muzzle rise and felt recoil, and ships with a hard case, tool roll, and magazines. The design targets 3-Gun, IPSC, home defense, and training applications with an adjustable adaptive stock, AR-compatible pistol grip, full-length Picatinny rail, flip-up iron sights, and threaded barrel. The Gist: Recently released (no specific date or retailers stated) Impact: $2,499.00 MSRP Bottom Line: 12 ga; 5/10-round magazine capacity; self-cleaning gas piston; 14″, 18″, or 20″ barrel options; 38″ OAL, 9.5 lb; folding iron sights, full Picatinny rail, mobile chokes (Full/Modified/IC), adjustable stock (12-15″ LOP), MAX Brake + double-buffered recoil system, ships with 2 magazines (6 + D-TAK optic in Factory Exclusive version) Theoutdoorwire SK Guns Relaunches Limited Edition Pancho Villa from La Revolucion Series in Stainless Steel SK Guns has relaunched the first pistol in its La Revolucion series as a limited-edition stainless steel Full Size Government Model Colt 1911 chambered in .38 Super. The highly polished revolver-style 1911 features selective 24k gold plating, intricate historical engravings commemorating Pancho Villa and the Mexican Revolution, and custom Antique Pearl Krinite grips with antique gold peso coin medallions. Limited to 300 units, it marks the 100th anniversary of Pancho Villa's passing (1878-1923). The Gist: Relaunched August 7, 2026; limited to 300 units; follow SK Guns on Instagram and Facebook for production launches Bottom Line: Caliber .38 Super; stainless steel frame, slide, barrel and hardware with selective 24k gold plating; engravings include Monument to the Revolution, “División del Norte” banner “Fusílenlo, después averiguamos”, Durango coat of arms, “REVOLUCION”, “El Centauro del Norte”, Pancho Villa portrait “1878-1923 Centenario”, bandolier with .30-30 cartridges, Mexico coat of arms 1899-1947, and Cannas floral scroll with selective shading; Antique Pearl Krinite grips with replica antique gold peso medallions Eaacorp Girsan Witness2311 CMXX The Girsan Witness2311 CMXX from EAA Corp. is a compensated single-action 2011-style pistol offered in 9mm, 10mm, and .45 ACP. It features an integral barrel compensator, 4.25″ bull barrel, lightening-cut slide, RMSc optic-ready footprint, tuned 4.5 lb trigger, auto firing pin block safety (no grip safety), ambidextrous thumb safety, full accessory rail, and improved high-texture grips with a Cerakote black finish. The Gist: Available for purchase now (listed as NEW on EAA Corp. website) Impact: Starting at $1,149 (MSRP) Bottom Line: 9mm (17+1), 10mm (15+1), or .45 ACP (11+1); 4.25″ bull barrel with integral compensator; RMSc optic ready, fiber optic front sight, tuned 4.5 lb trigger, auto firing pin block, ambidextrous thumb safety, full accessory rail, Cerakote black finish, EAA limited lifetime warranty Walkersgameear Walker's Game Ear Boomies Passive Muffs Walker's Game Ear Boomies Passive Muffs are a toddler-specific (ages 1–3) passive hearing protection product with a certified NRR of 23 dB. The slim, lightweight design features soft ear cushions, impact-resistant materials, and a contoured, stay-put fit engineered for active play and small head sizes without requiring batteries or electronic components. The Gist: Currently available for purchase (listed as new product with Add to Cart option) Impact: $29.99 MSRP Bottom Line: Passive NRR 23 dB; lightweight/contoured for toddlers 1–3 years; soft cushions, impact-resistant, stay-put fit for active indoor/outdoor use; no batteries or switches; SKU GWP-YM2-VAR Before we let you go – Join Gun Owners of America We'd love if you supported the show, join Agency 171 at agency171.com. Lot's of prizes, rewards and kick ass swag. No matter how tough your battle is today, we want you here fight with us tomorrow. Don't struggle in silence, you can contact the suicide prevention line by dialing 988 from your phone. Remember – Always prefer Dangerous Freedom over peaceful slavery. We'll see you next time! Nick – @busbuiltsystems | Bus Built Systems Jeremy – @ret_actual | Rivers Edge Tactical Aaron – @machinegun_moses Savage – @savage1r Shawn – @dangerousfreedomyt | @camorado.cam | Camorado

If you prefer to watch the video you can find it at the bottom of this webpage. Episode Sponsors: Talon Range Bag (Ready Up Gear) The Truth About Low-Light Webinar (FREE, Aug 13) About This Episode: We cover recent firearms industry news, including the Civilian Marksmanship Program's plan to sell former U.S. government M14 rifles to civilians in permanently semi-automatic form, and Auto-Ordnance's short-barreled M1 Carbine with a 12-inch barrel and suppressor threading. We also discuss a new range project in Cody, Wyoming, along with several new product announcements, including the KelTec Sub2000 SDP and the Springfield Armory Echelon Alpha. We then look at low-light training topics in an upcoming webinar with Dan Brady and close with a remembrance of Greg Motes and his role in shooting history and IPSC development. As always, any questions or suggestions for future episodes can be submitted to podcast@concealedcarry.com! New Stories Referenced: CMP to Sell Surplus M14 Rifles Auto-Ordnance “Shorty” M1 Carbine Factory SBR CMP’s $10M Challenge Grant to the Wyoming State Shooting Complex KelTec SUB-SDP: The SUB2000 Folds to 10″ Springfield Echelon Alpha 4.0C Springfield Goes Aimpoint COA: 1911 & DS Prodigy Moats’ Notes: IPSC’s 50th Year, a Reunion to Remember In Memoriam: Greg Moats (1952–2026) Thanks for Listening! Thanks so much for joining us this week. Have some feedback you'd like to share? Leave a note in the comment section below. If you enjoyed the podcast the biggest compliment you could give us would be to subscribe to future episodes via a podcast app on your phone or via iTunes. You can find past podcast episodes by clicking here. Video Recording: Press PLAY on the video below to watch the video recording! {"@context":"https://schema.org","@type":"VideoObject","@id":"https://www.concealedcarry.com#/schema/video/4254048","name":"S14E3: Old Iron, New Iron & Remembering a Giant","description":"Concealed Carry Podcast brought to you by Ready Up Gear - "S14E3: Old Iron, New Iron & Remembering a Giant" Episode Sponsors: -Talon Range Bag (Ready","thumbnailUrl":"https://i.ytimg.com/vi/z1Xf8Km13yo/maxresdefault_live.jpg","uploadDate":"2026-07-29T17:07:21-06:00","embedUrl":"https://www.concealedcarry.com/player-embed/id/4254048/?autoplay=0","duration":"PT55M07S","interactionStatistic":{"@type":"InteractionCounter","interactionType":{"@type":"http://schema.org/WatchAction"},"userInteractionCount":4}}

Send us Fan MailFor most of human history, scientists believed that once a cell became a skin cell, a neuron, or a heart cell, that identity was permanent. Then a group of researchers discovered something extraordinary: cells could be reset. My guest today was there when that discovery happened.Dr. Koji Tanabe, Ph.D. is Founder and CEO of I Peace ( https://ipeace.com/en/ ), one of the world's leading companies advancing induced pluripotent stem cell - or iPSC - technology from the research laboratory into scalable clinical manufacturing.Dr. Tanabe occupies a truly unique place in modern biomedical history. He earned his Ph.D. in the laboratory of Nobel Laureate Dr. Shinya Yamanaka at Kyoto University and was the second author on the landmark scientific paper that first demonstrated the successful creation of human induced pluripotent stem cells - a discovery that fundamentally changed regenerative medicine and ultimately earned Dr. Yamanaka the 2012 Nobel Prize.After helping establish one of the most important technologies in modern biology, Dr. Tanabe continued his work at Stanford University in the laboratory of Dr. Marius Wernig, a pioneer of direct cellular reprogramming, where he investigated how mature blood cells can be directly converted into neurons and explored the molecular mechanisms that govern cellular identity.In 2015, Dr. Tanabe founded I Peace with an ambitious vision: to make clinical-grade iPS cells accessible at industrial scale. Today, the company has developed automated GMP manufacturing platforms capable of producing personalized and clinical-grade iPS cells for researchers, pharmaceutical companies, and regenerative medicine programs around the world.On the episode we'll explore how far the field has come since those first groundbreaking experiments nearly two decades ago, where regenerative medicine stands today, the growing role of iPS cells in drug discovery and transplantation, the excitement surrounding in vivo reprogramming and partial cellular rejuvenation, and what may ultimately become possible when every individual has access to their own personalized stem cell bank.Important Episode Links - Future Medicine Lab with Koji Tanabe YouTube Channel -https://www.youtube.com/@FutureMedicineLabMy Peace (a service from I Peace) - Personal iPS Cell Banking Service - https://mypeace-personal-ipscbanking.com/en/#iPSC #StemCells #RegenerativeMedicine #CellularReprogramming #ShinyaYamanaka #NobelPrize #Biotechnology #Biotech #Longevity #AgingResearch #FutureMedicine #PrecisionMedicine #DrugDiscovery #CellTherapy #GeneEngineering #BiomedicalResearch #LifeSciences #HealthcareInnovation #MedicalInnovation #Science #Technology #Innovation #FutureOfMedicine #StemCellResearch #HumanBiology #SyntheticBiology #AIinMedicine #PharmaInnovation #DiseaseModeling #RegenerativeTherapySupport the show

Guest: Nobel Laureate Dr. Shinya Yamanaka is the Director Emeritus of the Center for iPS Cell Research and Application (CiRA), President of the CiRA Foundation, Professor at Kyoto University, and Senior Investigator at the Gladstone Institutes. 20 years after the discovery of iPSCs, he discusses how his lab is advancing iPSC therapies toward the clinic while continuing to investigate the basic mechanisms underlying pluripotency, stem cell biology, and translation initiation. He also shares his vision for the future of regenerative medicine, the ethical challenges posed by emerging stem cell technologies, and the opportunities created by combining iPSC with advances such as CRISPR and organoids. Featured Products and Resources: Get a free wallchart on the directed differentiation of hPSCs. Subscribe to STEMCELL Sceince News to stay current with the latest research and news in the fields of immunology and cell biology. The Stem Cell Science Round Up Elephant iPS Cells – Researchers have generated the first induced pluripotent stem cells from Asian elephants, providing a new platform for conservation and disease research. Epigenetic Cell Counter – Intestinal stem cells use an epigenetic division-counting mechanism to precisely control cell fate decisions during tissue maintenance. Reversing Bone Marrow Aging – Long-term vitamin C supplementation partially reverses age-related changes in primate bone marrow and hematopoietic stem cell function. Human Heart Atlas – A comprehensive atlas of human cardiac organoids reveals how signaling molecules regulate heart function and identifies pathways linked to heart failure. Photo Reference: Courtesy of Dr. Shinya Yamanaka. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

div]:bg-bg-000/50 [&_pre>div]:border-0.5 [&_pre>div]:border-border-400 [&_.ignore-pre-bg>div]:bg-transparent [&_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [&_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [&_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8"> _*]:min-w-0 gap-3 [&_>_*:last-child]:mb-0 print:block print:[&_>_*_+_*]:mt-3 progressive-markdown"> Over 50% of postmenopausal women experience significant hair loss. Most are dismissed. Most are spending money on products that don't work. And most have never had a proper hair loss workup from a provider who actually specializes in this. That changes today. Dr. Omer Ibrahim is a board-certified dermatologist and one of the most clinically sophisticated hair loss specialists in the country. This is the most comprehensive hair loss conversation you will hear, full of evidence-based treatments, action steps to take, and myths busted. Dr. Ibrahim treats hair loss every single day and understands the postmenopausal picture specifically. He is here to give you the truth. In this episode we cover: — The biology of hair loss at menopause — What is actually happening hormonally and why postmenopausal women are uniquely vulnerable — The specific types of hair loss and how the diagnosis changes everything about treatment — DHT and why estrogen loss amplifies its effect on your follicles — The complete lab panel every woman with hair loss should be requesting — When to get a scalp biopsy and what it tells you that labs cannot — In-office treatments — PRP, exosomes, Alma TED, and low-level laser therapy — what the evidence actually shows and who is the ideal candidate — Medications — oral minoxidil, finasteride, dutasteride, spironolactone, and how HRT intersects with hair loss treatment — Topicals — Rogaine, compounded formulas 82M, 82F, and 82D, the iPSC exosome topical formula, and rosemary oil — The social media overwhelm — scalp serums, caffeine shampoos, Nizoral, Kérastase, The Ordinary, Neutrogena, OneSkin OS-Hair, and the Hers minoxidil gummy — what works and what is wasting your money — The pipeline — what lies ahead — What to do this week if you have been losing hair for years and have no answers I share my own 30-year hair loss journey, and the equation I have built that works. If you have been told your hair loss is just aging and there is nothing to do, this episode will change everything for you. Find Dr. Ibrahim: IG: @chicagoskindoc Stay connected with JFW: Book your Menopause Care Consultation: https://www.jillfooswellness.com/menopause-care-consult-page Follow on Instagram: @jillfooswellness Follow on Facebook: @jillfooswellness Follow on YouTube: @jillfooswellness Grab discounts on my favorite menopause wellness products: https://www.jillfooswellness.com/health-products Enjoy 20% savings and free shipping at Fullscript for your favorite supplements by leading brands: https://us.fullscript.com/welcome/jillfooswellness/store-start Subscribe to the JFW newsletter at www.jillfooswellness.com and receive your FREE Guide on How To Create Your Menopause Health Equation Ebook. Schedule your free 15-minute consultation here: https://calendly.com/jillfooswellness/15-minute-zoom-consultations If you're a Chicago-area midlife woman, check out the Chicago Menopause Collective, a nonprofit dedicated to navigating menopause locally with experts: https://chicagomenopausecollective.org

Guest: Dr. Charles Easley is an Associate Professor and Associate Dean for Research at the University of Georgia. He discusses how his lab uses pluripotent stem cells and in vitro models of spermatogenesis to investigate how environmental exposures affect male fertility. He also explores efforts to generate functional sperm from stem cells, develop regenerative therapies for male infertility, and use human-based models to advance drug discovery and male contraception. Featured Products and Resources: Take your human pluripotent stem cell cultures further with mTeSR™ Plus from STEMCELL Technologies. Save time and keep current with ESC & iPSC News, a free bi-weekly newsletter covering all of the latest research and news. The Stem Cell Science Round Up Tracking Brain Organoid Maturation – Scientists have found that human brain organoids cultured for five years continue to mature and retain a molecular memory of time spent in culture. Oligodendrocytes and Cognitive Aging – Changes in oligodendrocytes and reduced NRF2 signaling are linked to cognitive decline during aging, identifying a potential therapeutic target. Maturing iPSC-Derived Cardiomyocytes – Generating tetraploid iPSCs produces cardiomyocytes with more mature molecular, metabolic, and functional properties than conventional iPSC-derived cardiomyocytes. Embryo Mechanics and Fertility – Reproductive aging increases embryo contractility and alters tissue mechanics, reducing the ability of embryos to implant successfully. Photo Reference: Courtesy of Dr. Charles Easley Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Building a cell therapy company is hard. Building a genetically engineered iPSC therapy for the brain, on a preclinical budget, is one of the hardest translational problems in biotech. Every experiment has to move the program closer to an IND, or it's motion without progress.That's the operating constraint Bilal Fares faces as CEO and co-founder of AzureCell, the University of Geneva spin-off engineering neuroprotective iPSC neurons for Parkinson's disease. In Part 2, he walks through how his team decides what to build, where AI and synthetic biology genuinely accelerate a CMC roadmap, and the four founder lessons he wishes he'd internalized earlier, including his conviction that scientists who use AI will replace those who don't.Topics discussed include:Strategies for prioritizing experiments and narrowing focus with limited resources (03:33)How business opportunity validation programs helped define a product roadmap (04:08)Integrating AI and synthetic biology into research programs—and where these tools do, and don't, accelerate development (05:07)Building a cell therapy platform for personalized approaches in neurological diseases beyond Parkinson's (06:38)Lessons learned in biotech leadership and why tackling big problems matters (08:08)Key advice for aspiring biotech entrepreneurs: kill your own solutions quickly, and learn from others (09:27)The importance of having a strong team and how a powerful mission attracts top talent (12:21)AzureCell's near-term plans and future goals, including upcoming fundraising and R&D milestones (13:30)Smart insight: What separates successful biotech ventures from the rest? According to Bilal Fares, it is not just technical skill but mindset. First, choose a problem large enough to be worth the struggle. Second, try to “kill your solution as fast as possible”—engage experts, enter competitions, and seek brutal feedback early so you can pivot, improve, or abandon as needed. And finally, plan with the end (approval, patients, impact) always in sight.If you enjoyed this, check out these episodes on cell therapy, where engineered cells can survive and do more than replace what's lost: Michael Rome's investor lens rounds it out for founders facing the same funding realities.Episodes 269 - 270: How to Turn Mesenchymal Stem Cells into Programmable Cancer Delivery Vehicles with Jun Yung WooEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 249 - 250: How T Cell Activation Redefines TIL and CAR-T Manufacturing (Boosting Success Rates to 95%) with Chantale BernatchezEpisodes 259 - 260: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael RomeConnect with Bilal Fares:LinkedIn: www.linkedin.com/in/b-fares AzureCell website: www.azurecell.co Email: info@azurecell.coSupport the show

Transplant iPSC-derived neurons into a Parkinson's brain and 97% die before they can restore function. Of the 3% that survive, most face the same pathogenic environment that killed the original neurons. This is the compounded biology and CMC problem defining CNS cell therapy today.Bilal Fares, neuroscience entrepreneur and co-founder of AzureCell, is translating a University of Geneva discovery into a genetically engineered iPSC platform built to solve it: neurons that don't just replace what Parkinson's destroyed, but survive the fire that destroyed them.Topics discussed:Why Bilal believes cell therapy is the future of medicine for brain diseases, and the limitations of other approaches (03:06)Bilal's personal story and the events that guided his commitment to Parkinson's research and entrepreneurship (04:03)How cell therapy might move beyond simply replacing lost neurons—using engineered cells to produce therapeutics directly in the brain (09:05)The neuroprotective technology AzureCell is developing, designed to shield transplanted neurons from Parkinson's disease mechanisms (11:31)The platform approach: combining stem cell technologies, genetic engineering, and allogeneic off-the-shelf cell banks (12:38)Why the blood-brain barrier makes cell therapy a necessary approach for certain conditions (13:26)The current status of Azure's preclinical and manufacturing development, and their plans for clinical translation (14:31)Why previous therapies for Parkinson's have fallen short, and how cell therapy might sidestep these limitations (15:57)The potential and challenges of using cell therapy for other brain diseases like Alzheimer's (18:26)Smart insight: The next generation of CNS cell therapy isn't only about neuron replacement. Bilal's thesis reframes transplanted cells as engineered biological factories inside the brain: producing neuroprotective proteins, modulating disease mechanisms in real time, and eventually enabling preventative treatment as manufacturing costs fall and safety matures.If you enjoyed this, check out these episodes on cell therapy, where engineered cells can survive and do more than replace what's lost: Michael Rome's investor lens rounds it out for founders facing the same funding realities.Episodes 269 - 270: How to Turn Mesenchymal Stem Cells into Programmable Cancer Delivery Vehicles with Jun Yung WooEpisodes 253 - 254: How to Source, Manufacture, and Scale the Earliest Stem Cells for Allogeneic Cell Therapy Without Ethical Barriers with Yuta LeeEpisodes 249 - 250: How T Cell Activation Redefines TIL and CAR-T Manufacturing (Boosting Success Rates to 95%) with Chantale BernatchezEpisodes 259 - 260: Why Strong Science Isn't Enough to Get Funded: What Investors Actually Look For with Michael RomeConnect with Bilal Fares:LinkedIn: www.linkedin.com/in/b-fares AzureCell website: www.azurecell.co Email: info@azurecell.coSupport the show

What does it take to build companies across chemistry, software, diagnostics, and cell therapy, then bring those lessons into regenerative medicine?In this episode of Entrepreneur Rx, host John Shufeldt sits down with Robin Smith, CEO of Wonderlab Bio, a Jetstream Venture Fund portfolio company, to discuss his journey as a multi-exit entrepreneur, scientist, and biotech leader. Robin shares how he began as a chemist, how one unexpected customer order became his first bootstrap chemical business, and how that early work led to innovations in electronic lab notebooks, big data, and applied science.The conversation explores Robin's path through Synthematix, ArtusLabs, and PerkinElmer, where he helped scale an informatics business and learned how to operate at a much larger level. Robin also reflects on the people, teams, and relationships that shaped his career, and why grit, optimism, and curiosity have been essential throughout his entrepreneurial journey.Robin and John also discuss the origins of Wonderlab Bio and its work in regenerative medicine, cell therapy, and CRISPR-enabled cell engineering. Wonderlab Bio is developing tools that help biotech and pharmaceutical companies use engineered human cell types, including cardiac cells, neurons, and liver cells, for drug screening, efficacy testing, and future personalized medicine applications.Beyond the science, the episode covers building through uncertainty, recovering valuable assets, playing the long game, hiring mistakes, founder resilience, and the difference between startup lifestyle and the hard work of building something that matters. Robin also shares advice for younger entrepreneurs: slow down enough to think, seek outside perspectives, build strong teams, and balance action with patience.About Robin Smith: Robin is a multi-exit entrepreneur with more than 25 years of experience building life science and technology companies. His career spans chemistry, biotechnology, software, diagnostics, informatics, fundraising, M&A, corporate development, and company formation. Robin founded Synthematix, which helped pioneer the electronic laboratory notebook market, and ArtusLabs, which was acquired by PerkinElmer and became part of the foundation for its informatics division. He has led global R&D teams and holds more than 20 foundational patents across life science and technology.About Wonderlab Bio: Wonderlab Bio is a regenerative medicine company focused on allogeneic induced pluripotent stem cells, or iPSCs, and differentiated cell therapies. The company is the custodian of a large allogeneic iPSC cell bank derived from more than 85,000 collected blood samples, with cells consented for commercial use. Wonderlab's platform supports scalable, off-the-shelf cell therapy applications across cardiac repair, neurological disease, osteoarthritis, longevity, disease modeling, tissue engineering, drug screening, and gene therapy delivery.About Xcellerant Ventures: Xcellerant is a venture capital firm that invests in innovative companies across healthcare, technology, defense, and other emerging industries. Through multiple funds and investment vehicles, the firm partners with visionary founders, provides strategic guidance, and helps connect investors with opportunities in the private markets.About Jetstream Venture Fund: Jetstream is an interval fund managed by Xcellerant Ventures, that seeks to provide investors access to early-stage, high-growth companies with flexible terms, lower minimums ($5,000 minimum), and no carried interest. Disclosure for Jetstream: Investors should carefully consider the investment objectives, risks, charges, and expenses of the Fund before investing. The prospectus contains this and other information about the Fund and can be obtained by emailing jetstream@sweaterfunds.com or by visiting www.jvf.vc. Please read the prospectus carefully before investing.

Discover how original Yamanaka co-author Dr. Koji Tanabe uses automated iPSC cassettes and autologous stem cell secretomes to reverse cellular aging and repair damaged joints.In this landmark episode of Modern Healthspan, we sit down with Dr. Koji Tanabe, founder and CEO of iPS, Inc. and co-author of the historic 2007 Nobel Prize-winning paper on human-induced pluripotent stem cells (iPSCs). Dr. Tanabe shares how twenty years of technological advancement have raised iPSC reprogramming efficiency from under 1% to over 80%, while cutting manufacturing costs through automated cleanroom cassettes. We discuss practical longevity applications available today, including autologous stem cell banking from a simple blood draw, secretome extract therapies for joint and skin rejuvenation, and Japan's approval of iPSC-derived heart tissue. Finally, Dr. Tanabe offers a critical scientific perspective on in vivo partial reprogramming, detailing the cellular identity loss and tumor risks associated with OSK gene delivery. Watch now to learn where stem cell age reversal truly stands today.

In dieser Folge geht es um Rückschritte. Olli und Silvana sprechen über Routinen, die dazu führen, dass sich die Leistung verschlechtert. Es geht darum, was dazu führt, wie man da wieder rauskommt und ob nicht generell irgendwann der Punkt kommt, wo eben alles nicht mehr so ist wie zu Top-Zeiten. Diese Folge hat viel mit Polizei und Verteidigungsschießen zu tun - aber ihr könnt euch sicherlich auch für das IPSC oder das Statische Schießen davon rausziehen. Oder ihr habt einfach Freude beim Zuhören.Wenn ihr Heisse Eisen unterstützen wollt, dann gern mit einem Kommentar unter den Podcastfolgen oder einer Bewertung auf der Podcastplattform Eurer Wahl. Ansonsten könnt ihr auch Merch kaufen - hier über diesen Shop.Bei Twitch könnt ihr ebenfalls jeden Montag dabei sein und über ein Abo euren support ausdrücken.Was generell aber immer geht, ist Feedback per Instagram oder eine Mail. Die Mail-Adresse findet ihr auf der Webseite heisseeisenberlin.de

233: On this episode, Eric Kamps joins the episode to give a full recap of Brew City through the eyes of the Match Director! We talk about his performance at the match, some issues that popped up, plans for the future Brew City and the upcoming IPSC themed NISA match! Check Out Our Partners & Affiliates For The Best Deals On Gear:

233: On this episode, Eric Kamps joins the episode to give a full recap of Brew City through the eyes of the Match Director!We talk about his performance at the match, some issues that popped up, plans for the future Brew City and the upcoming IPSC themed NISA match!Check Out Our Partners & Affiliates For The Best Deals On Gear:

Guest: In this special episode recorded live in Montréal, Canada at ISSCR 2026, Dr. Michael May, President and CEO of the Centre for Commercialization of Regenerative Medicine (CCRM), and Dr. Janet Rothberg, Senior Director of Process and Analytical Development at CCRM, explore how stem cell discoveries can be translated into commercially viable therapies through scalable manufacturing, company creation, investment, automation, and artificial intelligence. They emphasize the importance of considering manufacturing, quality control, market selection, reimbursement, and the evolving standard of care much earlier in the development process. They also share their vision for a future in which robust bioprocessing, better use of data, and improved regulatory and reimbursement models make iPSC-derived therapies more affordable and widely accessible.  Photo Reference: Courtesy of Drs. Michael May and Janet Rothberg Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Guest: In July 2026, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss the opening plenary, major advances in iPSC research, organoids, CRISPR, and space biology, as well as their live podcast recording on translating stem cell research into real-world therapies. They also share their impressions of the meeting, memorable sessions, and the excitement of reconnecting with colleagues and the stem cell community. Featured Products and Resources: Learn about organoid culture from the experts at STEMCELL using the Organoid Information Hub. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

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Guest: Dr. Mekayla Storer is an Associate Professor at the University of Cambridge and a Principal Investigator at the Cambridge Stem Cell Institute. She discusses how mammalian digit tips regenerate after injury, focusing on the formation of the blastema and the cellular and molecular mechanisms that distinguish regeneration from scarring. She highlights the role of the extracellular matrix, tissue mechanics, and regenerative microenvironments in directing tissue repair, and explores how insights from digit tip regeneration may inform strategies to promote regeneration in other organs. Featured Products and Resources: Join us at ISSCR and discover breakthroughs, technologies, and clinical insights you can take back to your lab. Kick start your own journal club using our free toolkit equipped with downloadable checklists and templates. The Stem Cell Science Round Up Modeling EMT in Human Cells – Scientists have developed a human iPSC-based platform that enables standardized, multimodal analysis of epithelial-to-mesenchymal transition dynamics across 2D and 3D contexts. Modeling Persistent Ebola Infection – Human brain organoids reveal how persistent Ebola virus infection in neural cells drives long-term inflammation and viral evolution. Reducing Retinal Graft Rejection – Transient JAK inhibition reduces immune rejection of stem cell-derived retinal grafts and improves visual recovery. Enhancing Renal Regeneration – Targeting ENPP1 with a therapeutic antibody enhances regeneration and restores function after acute kidney injury. Photo Reference: Courtesy of Dr. Mekayla Storer Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

BUFFALO, NY — June 23, 2026 — A new #research paper was #published in Volume 18 of Aging on May 28, 2026, titled “p38MAP kinase regulates senescence in human iPS-derived myocytes.” The study was led by first author Hiroki Sato and corresponding author Ryuichiro Sato from The University of Tokyo, along with corresponding author Makoto Shimizu from The University of Tokyo and Ochanomizu University. As people age, skeletal muscle gradually loses strength, mass, and function, contributing to frailty, reduced mobility, and an increased risk of falls. Although cellular senescence is widely recognized as a major driver of aging, the mechanisms that promote aging within mature muscle fibers remain poorly understood. In this study, researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to play a central role in the process. The research team used human induced pluripotent stem cell (iPSC)-derived myocytes, specialized muscle cells generated from stem cells. To mimic age-related cellular damage, the investigators exposed the cells to low-dose X-ray irradiation, which induced DNA damage without causing extensive cell death. The treated muscle cells developed several characteristics commonly associated with aging. They exhibited muscle fiber atrophy, reduced contractile activity, and increased expression of p21, a well-established marker of cellular senescence. The researchers also observed elevated production of senescence-associated secretory phenotype (SASP) factors, inflammatory and extracellular signaling molecules that are commonly released by senescent cells. To better understand the molecular changes involved, the investigators performed proteomic, transcriptomic, and functional analyses. These studies revealed activation of p38 mitogen-activated protein kinase (p38MAPK), a signaling pathway previously linked to cellular stress responses and aging in other tissues. Further experiments demonstrated that inhibiting p38MAPK partially attenuated several senescence-associated features in the muscle cells. Treatment with p38MAPK inhibitors reduced muscle fiber atrophy, improved contractile function, and suppressed the expression of several senescence-associated factors. Conversely, activating p38MAPK promoted aging-like changes in the cells, further supporting its role in regulating muscle cell senescence. The study also identified activation of an integrin–FAK/SRC–p38MAPK signaling axis following DNA damage. According to the authors, this pathway may help explain how cellular stress is translated into long-term functional decline in skeletal muscle. Importantly, the findings were supported by analyses of human muscle aging datasets, which showed increased activity of MAPK signaling, focal adhesion pathways, and cytokine-related signaling in older skeletal muscle tissue. Full press release - https://aging-us.net/2026/06/23/researchers-identify-key-signaling-pathway-driving-muscle-cell-aging/ DOI - https://doi.org/10.18632/aging.206385 Corresponding authors - Ryuichiro Sato - roysato@g.ecc.u-tokyo.ac.jp, and Makoto Shimizu - shimizu.makoto@ocha.ac.jp Abstract video - https://www.youtube.com/watch?v=ULm7R74CJx0 Website - https://www.Aging-US.com​​ Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

This week on Slam Fire Radio, the crew catches up on matches, gear upgrades, and the latest firearms news from across Canada. Dustin shares a personal story following the passing of his father, including introducing family members to shooting and restoring an old .22 rifle. Tony breaks down his latest 3-Gun adventures, pistol modifications, and … Continue reading Episode 659 – BOA Recap, Gun Ban Compliance Numbers, and Alberta IPSC in the Spotlight → The post Episode 659 – BOA Recap, Gun Ban Compliance Numbers, and Alberta IPSC in the Spotlight appeared first on Slam Fire Radio.

Olli und Silvana haben diesmal so einiges zu besprechen: sei es die unerwünschte Präsenz bei der Waffenbehörde und die daraus resultierenden möglichen Folgen. Oder seien es die unnötigen zusätzlichen Schritte, die das LKA jetzt einfordert bevor man ein neues Sportgerät überhaupt nutzen kann. Oder seien es fehlende Hinweise zur Live-Übertragung der European Championships im IPSC in Ungarn. Die Videos davon könnt ihr euch aber auch im Nachhinein noch anschauen, hier stehen die Live-Streams der Veranstaltung noch zur Verfügung: https://www.youtube.com/@ActionStreamingLive/streamsFalls ihr Merch von Heisse Eisen wollt, könnt ihr ⁠das hier kaufen⁠. Getwitcht wird immer montags ab 19.30 Uhr ⁠hier⁠.Und falls ihr Kontakt aufnehmen wollt, geht das über das Formular auf der Internetseite⁠ heisseeisenberlin.de⁠, dort findet ihr auch die Mail-Adresse. Oder ihr schreibt per ⁠Instagram⁠.

The Ireland-Palestine Solidarity Campaign (IPSC) has expressed its disappointment that the FAI wishes to proceed with the fixtures against Israel in a third country, likely Hungary... And Zoe Lawlor joins me on the line now...

We love to hear from our listeners. Send us a message. On this week's episode of the Business of Biotech, Marinna Madrid, Ph.D., Cofounder, Board Member, Chief Product and Regulatory Officer at Cellino, talks about scaling up an automated manufacturing process she co-invented for personalized autologous induced pluripotent stem cell (iPSC) therapies using laser-activated substrates and AI. Marinna describes her work with industry groups to improve regulatory guidelines, Cellino's partnership strategy, the implications of receiving FDA's Advanced Manufacturing Technologies designation, and the future of iPSC therapies.  Access this and hundreds of episodes of the Business of Biotech videocast under the Business of Biotech tab at lifescienceleader.com.  Subscribe to our monthly Business of Biotech newsletter. Get in touch with guest and topic suggestions: ben.comer@lifescienceleader.comFind Ben Comer on LinkedIn: https://www.linkedin.com/in/bencomer/

This week the crew is joined by Ken from P3 Shooting Specialties to talk about one of the most interesting developments in Canadian handgun ownership since the freeze began: commercial handgun lending programs in Alberta. Ken explains how P3 Shooting Specialties is helping RPAL holders legally access handguns for IPSC competition, training, and skill development … Continue reading Episode 654 – Handgun Lending with P3 → The post Episode 654 – Handgun Lending with P3 appeared first on Slam Fire Radio.

Guest: Dr. Andrew Gaffney is Vice President, iPSC Platform at STEMCELL Technologies. In this episode, he discusses how his team is advancing pluripotent stem cell applications through high-quality iPSC line development, gene editing, organoid production, and GMP manufacturing for translational and clinical use. He also highlights key challenges in the field, including reproducibility, standardization, genetic diversity, and freedom-to-operate considerations, and explains how these factors impact the path from basic research to commercialization. Featured Products and Resources: Explore STEMCELL Technologies’ one-stop resource for organoids. Join us at ISSCR 2026 and be part of the global conversation shaping the future of stem cell research. The Stem Cell Science Round Up Transgene-Free Gastrulation Model – Scientists have produced a transgene-free stem cell model that recreates key features of human peri-gastrulation, including germ layer formation and early hematopoiesis. Engineering Antibody-Producing Stem Cells – CRISPR-edited hematopoietic stem cells generate B cells that produce durable, protective antibodies following vaccination. Safeguarding Chemical Reprogramming – Investigators have found that p53 is required for efficient chemical reprogramming by maintaining genomic stability and regulating early cell state transitions. Targeting Barriers to Cardiac Repair – Knockdown of calreticulin enhances cardiac reprogramming and improves heart repair after injury. Photo Reference: Courtesy of Dr. Andrew Gaffney Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

In this episode, we dive into the future of brain repair with Dr. Ruslan Rust, Assistant Professor of Research Physiology and Neuroscience at the Keck School of Medicine at USC. With over 15 years of experience in translational neuroscience, Dr. Rust is developing cutting-edge gene-edited, induced pluripotent stem cell (iPSC)-derived therapies aimed at overcoming the toughest challenges in brain regeneration, including crossing the blood-brain barrier, immune rejection, and long-term safety. Dr. Rust's pioneering work combines advanced stem cell biology, genetic engineering, and AI-driven analytics to transform the treatment landscape for stroke recovery and neurodegenerative diseases like Alzheimer's. In this conversation, we explore: The current limitations of stem cell therapies in treating stroke and neurodegeneration. How stem cells are harvested and engineered to navigate the blood-brain barrier. The role of gene-edited iPSC-derived cells in enhancing brain repair. How AI and single-cell omics are accelerating breakthroughs in neurodegeneration. With his background in bio-entrepreneurship and scientific leadership, Dr. Rust offers a practical approach to turning innovative neuroscience into viable therapies. Tune in for a glimpse into the future of stroke recovery and Alzheimer's treatment. To follow Dr. Ruslan Rust's research, visit his academic website or follow him on X. Episode also available on Apple Podcasts: https://apple.co/38oMlMr 

In this episode, Molecular Therapy Editor-in-Chief Dr. Joseph Glorioso and Dr. Rita Perlingeiro (University of Minnesota) will discuss an article recently published in Molecular Therapy titled, “Preclinical quality, safety, and efficacy of a CGMP iPSC-derived myogenic progenitor product for the treatment of muscular dystrophies.” Music: 'Electric Dreams' by Scott Buckley - released under CC-BY 4.0. www.scottbuckley.com.auShow your support for ASGCT!: https://asgct.org/membership/donateSee omnystudio.com/listener for privacy information.

Thomas is a Classic division IPSC competitor. He was on Team Philippines which earned a silver medal only 7.5 points behind the American team. He was also 7th overall in the world. Even with such a high finish at a World Championship Match, oddly enough, he is a Casual Shooter. I can only imagine how great he would be if he focused on shooting like most Top 10 competitors in the world. This is the conclusion of our 2-hour conversation. https://www.instagram.com/thomas.shoots/ If you want to take a Mental Management class with Steve Anderson, follow the link below and use CSP10 for 10% off. https://www.andersonshooting.com/training ps://lbr8.link/@Casualshooterpodcast

In this STtalks we learn about the critical contributions made by Cytonome®-ST to achieve a major milestone in regenerative medicine by getting the approval for an iPSC-derived Parkinson's cell therapy developed by Sumitomo Pharma and RACK-THERA in Japan. John Sharpe, Cytonome®-ST COO, explains Cytonome®-ST's biotechnology engineering focus on measuring and isolating cells, its evolution from Genesis platforms, and how global reliability is maintained through consistency and quality control, along with connected monitoring systems. He emphasizes the importance of single-cell selection, high-throughput performance, and why precise selection is critical in regenerative medicine because “the cells are the drug.”

Thomas is a Classic division IPSC competitor. He was on Team Philippines which earned a silver medal only 7.5 points behind the American team. He was also 7th overall in the world. Even with such a high finish at a World Championship Match, oddly enough, he is a Casual Shooter. I can only imagine how great he would be if he focused on shooting like most Top 10 competitors in the world. This is Part 1 of a 2-hour conversation. https://www.instagram.com/thomas.shoots/ If you want to take a Mental Management class with Steve Anderson, follow the link below and use CSP10 for 10% off. https://www.andersonshooting.com/training ps://lbr8.link/@Casualshooterpodcast

Send us Fan MailBack in 2022, we had Sarah Hall, Project and events manager of The MidwayUSA Foundation, on to discuss who they are, and the amazing support they give to the youth shooting sports. If you have not heard that episode, we highly encourage you to listen to it, before listening to this episode. The numbers were mind blowing in 2022, and now they are even more staggering!   Jake Spengler of Rocky Creek Sporting clays, co-hosts this episode, as Pete Eisentrager, the Executive Director, joins us to discuss where they are now, in terms of support with the youth shooting sports. We then dive into a vast array of topics surrounding the organization. How do they help? How can you help? What are some of the misconceptions about the Foundation? What is their vision?   You are going to want to hear this!Dead Pair Swag- https://x062jy-1z.myshopify.com.Kolar Arms – https://www.kolararms.com Fiocchi USA – https://fiocchiusa.comGun & Trophy Insurance – https://gunandtrophy.com/                                         Atlas Traps – https://www.atlastraps.comRhino Chokes – https://rhinochokes.comRanger Shooting Eyewear – https://www.reranger.com   Ranger 10% Discount = DEADPAIR10Taconic Distillery – https://www.spirits.taconicdistillery.com/  Discount -DEADPAIR10Long Range – https://www.longrangellc.comMidwayUSA Foundation - https://www.midwayusafoundation.orgSlick Products – https://www.slickproductsusa.com/deadpair     ElJefe Energy – https://www.eljefe.com OtoPro Technologies - https://otoprotechnologies.comBarepelt - https://barepelt.comScore Chaser – https://scorechaser.com/NSSF Plus One – https://www.nssf.org/plusone/                                                              Clay Range Design Works – https://traptowers.coSupport the showThe Dead Pair Podcast - https://thedeadpair.com  FACEBOOK- https://www.facebook.com/Thedeadpair. INSTAGRAM- https://www.instagram.com/thedeadpairpodcast/YOUTUBE- https://youtube.com/channel/UCO1ePh4I-2D0EABDbKxEgoQ

Watch it on Rumble! In this episode of Behind the Lens, host Brian of Hunter's HD Gold sits down with Leighton, the US Regional Director for IPSC, to trace his remarkable journey from a LEO in South Africa to a pivotal leader in the American shooting sports community. The conversation dives deep into the technicalities of IPSC team selection, the logistical hurdles of expanding international match slots, and Leighton's ambitious new venture, Action Streaming Live, which aims to revolutionize how the sport is broadcast globally. Elevate your game with our trusted partners: Right To Bear Use Code HuntersHD10 When you sign up part of your contribution will go back to the Shooting Sports. Get Carry Insurance with a Company that Supports the Shooting Sports.  IWI Use Code HDG15 for 15% off your order  RealAvid Use Code RAHHDG for 10% off your order  Ghost HolsterUSA Use Code HuntersHD 15% off Jessie James JJFU Coffee Use Code HuntersHD for 5% off ACE Virtual Shooting Use Code HHDG for 10% off your subscription and physical handset. Imperium Roots Use Code HuntersHD for 20% off Speed Beez Use Code HuntersHD for 10% off LOK Grips Use Code HunterHD for 10% off SensGard Use Code HuntersHD for 15% off FPS holsters Use Code HHDG10 for 10% off -Safety Notice- Your safety is our utmost priority. We promote the safe and responsible ownership and use of firearms. All activities showcased on our platform are conducted in a safe, controlled environment by professionals. Whether you're a new firearm owner, considering Discover the world of competitive shooting sports through the eyes of industry leaders, top athletes, and match directors in the Behind the Lens Podcast, hosted by Brian Conley of Hunters HD Gold. Delve into captivating conversations that reveal the passion, dedication, and skill that define the shooting sports community. Brian, a steadfast supporter of the shooting sports, brings unique insights and expertise to each episode. Uncover the latest trends, techniques, and stories from the people who shape the shooting sports landscape. Join us as we explore the dynamic world of competitive shooting, the shooting industry, and the remarkable individuals who make it all possible.

Watch it on Rumble!In this episode of Behind the Lens, host Brian of Hunter's HD Gold sits down with Leighton, the US Regional Director for IPSC, to trace his remarkable journey from a LEO in South Africa to a pivotal leader in the American shooting sports community. The conversation dives deep into the technicalities of IPSC team selection, the logistical hurdles of expanding international match slots, and Leighton's ambitious new venture, Action Streaming Live, which aims to revolutionize how the sport is broadcast globally.Elevate your game with our trusted partners:Right To Bear Use Code HuntersHD10 When you sign up part of your contribution will go back to the Shooting Sports. Get Carry Insurance with a Company that Supports the Shooting Sports. IWI Use Code HDG15 for 15% off your order RealAvid Use Code RAHHDG for 10% off your order Ghost HolsterUSA Use Code HuntersHD 15% offJessie James JJFU Coffee Use Code HuntersHD for 5% offACE Virtual Shooting Use Code HHDG for 10% off your subscription and physical handset.Imperium Roots Use Code HuntersHD for 20% offSpeed Beez Use Code HuntersHD for 10% offLOK Grips Use Code HunterHD for 10% offSensGard Use Code HuntersHD for 15% offFPS holsters Use Code HHDG10 for 10% off-Safety Notice- Your safety is our utmost priority. We promote the safe and responsible ownership and use of firearms. All activities showcased on our platform are conducted in a safe, controlled environment by professionals. Whether you're a new firearm owner, consideringDiscover the world of competitive shooting sports through the eyes of industry leaders, top athletes, and match directors in the Behind the Lens Podcast, hosted by Brian Conley of Hunters HD Gold. Delve into captivating conversations that reveal the passion, dedication, and skill that define the shooting sports community. Brian, a steadfast supporter of the shooting sports, brings unique insights and expertise to each episode. Uncover the latest trends, techniques, and stories from the people who shape the shooting sports landscape. Join us as we explore the dynamic world of competitive shooting, the shooting industry, and the remarkable individuals who make it all possible.Hunters HD Gold Links:Website: https://huntershdgold.comInstagram: https://www.instagram.com/huntershdgold/Facebook: https://www.facebook.com/HuntersHDGoldYouTube: https://www.youtube.com/channel/UCBWH4kOqaX-x34uYOviQ-tgUnited States Practical Shooting Association Official Eyewear: https://uspsa.orgSteel Challenge Shooting Association Official Eyewear: https://scsa.orgMetal Madness Official Eyewear: https://...

Episode 268 Hunters HD Gold Behind the Lens Meetings, Registrations and Slots! OH MY with Jake Martens and Billy Herrington! In this podcast, Jake Martens and Billy Harrington highlight USPSA's record growth, noting 1,239 new members in February and a 22% activity spike. They discuss club reaffiliation, the technical nuances between Limited and Carry Optics divisions, and upcoming Nationals. Key initiatives include long-term strategic stability, membership retention via multi-year discounts, and a new club referral program. The episode also notes rising international interest in IPSC and Steel Challenge. Elevate your game with our trusted partners: Right To Bear Use Code HuntersHD10 When you sign up part of your contribution will go back to the Shooting Sports. Get Carry Insurance with a Company that Supports the Shooting Sports.  IWI Use Code HDG15 for 15% off your order  RealAvid Use Code RAHHDG for 10% off your order  Ghost HolsterUSA Use Code HuntersHD 15% off Jessie James JJFU Coffee Use Code HuntersHD for 5% off ACE Virtual Shooting Use Code HHDG for 10% off your subscription and physical handset. Imperium Roots Use Code HuntersHD for 20% off Speed Beez Use Code HuntersHD for 10% off LOK Grips Use Code HunterHD for 10% off SensGard Use Code HuntersHD for 15% off FPS holsters Use Code HHDG10 for 10% off -Safety Notice- Your safety is our utmost priority. We promote the safe and responsible ownership and use of firearms. All activities showcased on our platform are conducted in a safe, controlled environment by professionals. Whether you're a new firearm owner, considering

Watch it on Rumble!In this podcast, Jake Martens and Billy Harrington highlight USPSA's record growth, noting 1,239 new members in February and a 22% activity spike. They discuss club reaffiliation, the technical nuances between Limited and Carry Optics divisions, and upcoming Nationals. Key initiatives include long-term strategic stability, membership retention via multi-year discounts, and a new club referral program. The episode also notes rising international interest in IPSC and Steel Challenge.Elevate your game with our trusted partners:Right To Bear Use Code HuntersHD10 When you sign up part of your contribution will go back to the Shooting Sports. Get Carry Insurance with a Company that Supports the Shooting Sports. IWI Use Code HDG15 for 15% off your order RealAvid Use Code RAHHDG for 10% off your order Ghost HolsterUSA Use Code HuntersHD 15% offJessie James JJFU Coffee Use Code HuntersHD for 5% offACE Virtual Shooting Use Code HHDG for 10% off your subscription and physical handset.Imperium Roots Use Code HuntersHD for 20% offSpeed Beez Use Code HuntersHD for 10% offLOK Grips Use Code HunterHD for 10% offSensGard Use Code HuntersHD for 15% offFPS holsters Use Code HHDG10 for 10% off-Safety Notice- Your safety is our utmost priority. We promote the safe and responsible ownership and use of firearms. All activities showcased on our platform are conducted in a safe, controlled environment by professionals. Whether you're a new firearm owner, consideringDiscover the world of competitive shooting sports through the eyes of industry leaders, top athletes, and match directors in the Behind the Lens Podcast, hosted by Brian Conley of Hunters HD Gold. Delve into captivating conversations that reveal the passion, dedication, and skill that define the shooting sports community. Brian, a steadfast supporter of the shooting sports, brings unique insights and expertise to each episode. Uncover the latest trends, techniques, and stories from the people who shape the shooting sports landscape. Join us as we explore the dynamic world of competitive shooting, the shooting industry, and the remarkable individuals who make it all possible.Hunters HD Gold Links:Website: https://huntershdgold.comInstagram: https://www.instagram.com/huntershdgold/Facebook: https://www.facebook.com/HuntersHDGoldYouTube: https://www.youtube.com/channel/UCBWH4kOqaX-x34uYOviQ-tgUnited States Practical Shooting Association Official Eyewear: https://uspsa.orgSteel Challenge Shooting Association Official Eyewear: https://scsa.orgMetal Madness Official Eyewear: https://...

Send a text      It seems nowadays that there a lot of coaches coming out with their own app. But what about an app that anyone, including coaches, can use with their students? What if someone just wanted to do their own journaling, record keeping, and track their own progress, regardless of coach?  Meet Matthew Burlingame, who has created the Breakin' Clays App! Matthew is somewhat new to the game, but saw a definitive need for the app, not only for sporting clays, but trap, skeet, and the various disciplines within sporting clays, like 5 stand, FITASC, etc.. Chad Roberts co-hosts this episode as we dive into what the app does, what the future plans for the app are, how much it cost, and so much more!  Breakin' Clays App - https://breakinclays.com/Dead Pair Swag- https://x062jy-1z.myshopify.com.Kolar Arms – https://www.kolararms.com Fiocchi USA – https://fiocchiusa.comGun & Trophy Insurance – https://gunandtrophy.com/                                         Atlas Traps – https://www.atlastraps.comRhino Chokes – https://rhinochokes.comRanger Shooting Eyewear – https://www.reranger.com   Ranger 10% Discount = DEADPAIR10Taconic Distillery – https://www.spirits.taconicdistillery.com/  Discount -DEADPAIR10Long Range – https://www.longrangellc.comMidwayUSA Foundation - https://www.midwayusafoundation.orgSlick Products – https://www.slickproductsusa.com/deadpair     ElJefe Energy – https://www.eljefe.com OtoPro Technologies - https://otoprotechnologies.comBarepelt - https://barepelt.comScore Chaser – https://scorechaser.com/NSSF Plus One – https://www.nssf.org/plusone/                                                              Clay Range Design Works – https://traptowers.coSupport the showThe Dead Pair Podcast - https://thedeadpair.com FACEBOOK- https://www.facebook.com/Thedeadpair. INSTAGRAM- https://www.instagram.com/thedeadpairpodcast/YOUTUBE- https://youtube.com/channel/UCO1ePh4I-2D0EABDbKxEgoQ

Guest: Drs. Shuibing Chen and Hans Clevers, members of the Steering Committee for the ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development, discuss the need to accelerate the responsible integration of stem cell–derived models into preclinical drug development. Their conversation reflects growing regulatory and policy momentum around new approach methodologies (NAMs) and underscores the importance of rigorous standards, regulatory alignment, and cross-sector collaboration to improve reproducibility and advance more predictive, human-relevant therapies. Building on its long-standing leadership in global standards, ethics, and policy, the ISSCR is uniquely positioned to convene industry, academia, and regulators around this effort. The initiative also reflects the Society's expanding industry engagement, with industry membership increasing nearly 180% over the past five years – creating new opportunities for strategic partnerships to address shared scientific and translational challenges. Featured Products and Resources: Learn how organoids can be used to expand clinical applications of diseases and disorders.   Get a free wallchart showing how organoids are used as model systems to study infectious diseases, cancer, congenital disorders, and tissue regeneration. The Stem Cell Science Round Up Treating Frailty with Stem Cells – In a clinical trial, mesenchymal stem cell therapy improved walking distance and physical function in older adults with frailty. Combined Bone & Bone Marrow Organoids – Researchers developed a scalable iPSC-derived bone marrow organoid that models human lympho-myeloid hematopoiesis and disease. CAR-NK Progenitors Prevent Relapse – Engineered pluripotent stem cell–derived CAR-expressing NK progenitor cells reduced minimal residual disease and prevented relapse in leukemia models following chemotherapy. Whole-Body Single-Cell Mapping – Scientists have developed a 3D single-cell-resolution map of mouse organs and the whole neonatal body. Photo Reference: Courtesy of Drs. Shuibing Chen and Hans Clevers Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Howard Federoff, Scientific Co-Founder, Chief Medical Officer, and Executive Vice President of Corporate Medicine and Science at Kenai Therapeutics, is developing a cell therapy for Parkinson's disease that involves transplanting IPSCs into the brain to replace lost dopamine neurons.  The goal is not to cure the underlying cause of the disease, but to restore motor function and reverse the disease's progression. Initial clinical focus was on patients with moderate to moderate-severe idiopathic Parkinson's, showing efficacy and safety, leading to expanding the study to include earlier-stage and familial forms of the disease. Howard explains, "Kenai was formed about three and a half years ago, and the intention is to develop a cellular product, which means that what is manufactured will be eligible in the right patient groups who have a diagnosis of Parkinson's to be placed into the brain. And consequent to its placement, the cells will then form new circuits, dopamine circuits that are lost owing to the disease diagnosis that will have occurred years earlier." "The induced pluripotent stem cell approach is one we favor for several reasons. The nature of what then becomes the IPSC, as we like to call it, starts with a normal human volunteer whose medical history is very detailed and does not contain any familial personal history of neurodegeneration. That cell then undergoes a process called reprogramming. And in our case, it's done with a slightly different approach than many others. And the reprogramming effectively creates a cell that is pluripotent, meaning it can become any cell of the body. That's when it is designated as an induced pluripotent stem cell."  #KenaiTherapeutics #ParkinsonsDisease #CellTherapy #StemCells #Neuroscience #MedicalInnovation #ClinicalTrials #RegenerativeMedicine #Biotechnology #BioTech #AdvancedBiologics #NeurologicalDisorders #Neurology #DrugDevelopment KenaiTx.com Download the transcript here  

Dr. Howard Federoff, Scientific Co-Founder, Chief Medical Officer, and Executive Vice President of Corporate Medicine and Science at Kenai Therapeutics, is developing a cell therapy for Parkinson's disease that involves transplanting IPSCs into the brain to replace lost dopamine neurons.  The goal is not to cure the underlying cause of the disease, but to restore motor function and reverse the disease's progression. Initial clinical focus was on patients with moderate to moderate-severe idiopathic Parkinson's, showing efficacy and safety, leading to expanding the study to include earlier-stage and familial forms of the disease. Howard explains, "Kenai was formed about three and a half years ago, and the intention is to develop a cellular product, which means that what is manufactured will be eligible in the right patient groups who have a diagnosis of Parkinson's to be placed into the brain. And consequent to its placement, the cells will then form new circuits, dopamine circuits that are lost owing to the disease diagnosis that will have occurred years earlier." "The induced pluripotent stem cell approach is one we favor for several reasons. The nature of what then becomes the IPSC, as we like to call it, starts with a normal human volunteer whose medical history is very detailed and does not contain any familial personal history of neurodegeneration. That cell then undergoes a process called reprogramming. And in our case, it's done with a slightly different approach than many others. And the reprogramming effectively creates a cell that is pluripotent, meaning it can become any cell of the body. That's when it is designated as an induced pluripotent stem cell."  #KenaiTherapeutics #ParkinsonsDisease #CellTherapy #StemCells #Neuroscience #MedicalInnovation #ClinicalTrials #RegenerativeMedicine #Biotechnology #BioTech #AdvancedBiologics #NeurologicalDisorders #Neurology #DrugDevelopment KenaiTx.com Listen to the podcast here  

Guest: Dr. Joseph Wu is a Professor of Medicine and Radiology and the Director of the Stanford Cardiovascular Institute. He talks about the importance of pharmacology knowledge in drug discovery. He also discusses his early iPSC research, investigating vaccine-induced myocarditis, and embracing New Approach Methodologies (NAMs). (39:40) Featured Products and Resources: Submit your abstract for ISSCR 2026 by February 25th! STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit The Stem Cell Science Round Up Autism Genes in Organoids: Research provides new insight into the convergent impact of autism spectrum disorder genetic risk on human neurodevelopment. (2:35) Pancreatic Organoid Screening: High-content screen reveals 54 compounds altering pancreatic organoid shape or differentiation. (13:15) CRISPR Screening for Tauopathies: CRISPR screens in human neurons reveal modifiers of tau oligomer accumulation. (21:03) Fixing Facial Scarring: Modulating ROBO2-EID1-EP300 signaling pathway promotes facial-like reduced fibrosis at scar-prone sites. (31:00) Image courtesy of Dr. Joseph Wu Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

My guest this week has been shooting for 8 years and has traveled the globe competing in IPSC matches, as well as USPSA. We talk about how she got here and where she's going in the shooting sports. There is also talk of a future travel vlog with her husband. Enjoy!! https://www.instagram.com/kay_lane_shooting/ https://lbr8.link/@Casualshooterpodcast  

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on the use of innovative, human-relevant technologies to better characterize the biological effects of chemicals. New technologies, including advanced cell-based assays, organoids, and computational modeling approaches, are expanding the toolbox researchers use to answer previously difficult or unanswerable questions. Presenters will discuss how these emerging methodologies are being applied to uncover mechanistic insights, improve predictive accuracy for human health outcomes, and refine risk assessment frameworks. The third and final session, titled Innovative Methods for Understanding Chemical Toxicity, will feature three speakers discussing innovative approaches to understanding the dose at which chemicals trigger biological responses and the mechanisms behind them. Speakers include:Ana Maretti Garcia, Ph.D., University of Southern California: In this presentation, Dr. Maretti Garcia will discuss recent advances using advanced 3D human liver spheroid models to characterize the biological effects of multiple per- and polyfluoroalkyl substances (PFAS) on human liver metabolism and their contribution to metabolic dysfunction-associated steatotic liver disease (MASLD). She will highlight key findings recently published in Environment International (PMID: 40914107) and Communications Medicine (PMID: 41162609), focusing on molecular and cellular mechanisms identified through the integration of in vitro models with human-relevant data.Guru Ulaganathan, Duke University: Developmental neurotoxicity (DNT) is challenging to study due to the intricacy of human brain development, the dependence on the timing of exposure, and the emergence of effects long after the initial exposure. This presentation will discuss advances in human iPSC modeling using three-dimensional brain models that can be leveraged to mechanistically investigate neurodevelopmental perturbations at both a molecular and functional level.Weihseuh A. Chiu, Ph.D., Texas A&M University: Chemical contamination after disasters presents a plethora of challenges to risk assessment and risk management. Dr. Chiu will present several case studies from the Texas A&M Superfund Research Center of new approach methodologies (NAMs) to address this challenge by rapidly characterizing hazards and risks from individual chemicals and environmental mixtures. Lessons learned from these studies inform a general strategy for NAMs-based solutions for next generation risk assessment. To learn more about and register for the other sessions in this webinar series, please see the SRP site. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRP-BioChem-3_012126/

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on the use of innovative, human-relevant technologies to better characterize the biological effects of chemicals. New technologies, including advanced cell-based assays, organoids, and computational modeling approaches, are expanding the toolbox researchers use to answer previously difficult or unanswerable questions. Presenters will discuss how these emerging methodologies are being applied to uncover mechanistic insights, improve predictive accuracy for human health outcomes, and refine risk assessment frameworks. The third and final session, titled Innovative Methods for Understanding Chemical Toxicity, will feature three speakers discussing innovative approaches to understanding the dose at which chemicals trigger biological responses and the mechanisms behind them. Speakers include:Ana Maretti Garcia, Ph.D., University of Southern California: In this presentation, Dr. Maretti Garcia will discuss recent advances using advanced 3D human liver spheroid models to characterize the biological effects of multiple per- and polyfluoroalkyl substances (PFAS) on human liver metabolism and their contribution to metabolic dysfunction-associated steatotic liver disease (MASLD). She will highlight key findings recently published in Environment International (PMID: 40914107) and Communications Medicine (PMID: 41162609), focusing on molecular and cellular mechanisms identified through the integration of in vitro models with human-relevant data.Guru Ulaganathan, Duke University: Developmental neurotoxicity (DNT) is challenging to study due to the intricacy of human brain development, the dependence on the timing of exposure, and the emergence of effects long after the initial exposure. This presentation will discuss advances in human iPSC modeling using three-dimensional brain models that can be leveraged to mechanistically investigate neurodevelopmental perturbations at both a molecular and functional level.Weihseuh A. Chiu, Ph.D., Texas A&M University: Chemical contamination after disasters presents a plethora of challenges to risk assessment and risk management. Dr. Chiu will present several case studies from the Texas A&M Superfund Research Center of new approach methodologies (NAMs) to address this challenge by rapidly characterizing hazards and risks from individual chemicals and environmental mixtures. Lessons learned from these studies inform a general strategy for NAMs-based solutions for next generation risk assessment. To learn more about and register for the other sessions in this webinar series, please see the SRP site. To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRP-BioChem-3_012126/

How is advanced genetic engineering, stem cell biology, and AI-driven analytics reshaping the future of brain repair? Dr. Ruslan Rust, an Assistant Professor of Research Physiology and Neuroscience at the Keck School of Medicine of USC, joins the podcast to share his insights… With over 15 years of translational neuroscience research, Dr. Rust is developing next-generation gene-edited, induced pluripotent stem cell (iPSC)-derived therapies designed to overcome the biggest barriers in cell therapy — crossing the blood-brain barrier, immune rejection, and long-term safety. Dive in now to find out: Why current stem cell therapies struggle in stroke and neurodegenerative disease. Where stem cells are harvested.  How gene-edited iPSC-derived cells are engineered to cross the blood-brain barrier. The role of AI and single-cell omics in optimizing brain repair strategies. With additional training in MBA, bio-entrepreneurship, and scientific leadership, Dr. Rust brings a uniquely pragmatic lens to what it actually takes to turn cutting-edge neuroscience into viable therapies. Listen now for a rare look at how stroke recovery and Alzheimer's treatment may move from experimental promise to real clinical impact. You can keep up with Ruslan on X or by visiting his USC academic website!

To kick off Season 4, Charles Marmar, MD, explains how precision psychiatry is reshaping the way clinicians and researchers think about diagnosis, treatment selection, and the underlying biology of psychiatric disorders. This conversation is a overview of where the field stands today—including emerging molecular markers, biologically informed subtypes, and new translational approaches inspired by oncology and other precision-based specialties.Dr. Marmar is Chair of Psychiatry at NYU Grossman School of Medicine, and Director of the Center for the Study of Alcohol Use Disorder and Traumatic Stress.In this episode, he outlines current work on:Molecular and genomic signatures that may distinguish patient subtypesClinical trials examining targeted treatments for alcohol use disorderThe development of proxy “brain biopsy” methods such as exosomal analyses and iPSC-derived organoidsHow converging biological data could eventually support more individualized treatment planningThis discussion reflects ongoing efforts at NYU Langone Health to move psychiatry toward a more mechanism-based, biologically grounded model of care, while acknowledging the complexity and early stage of the work. For clinicians, scientists, and trainees, the episode provides a clear snapshot of the major directions shaping precision psychiatry today.CHAPTERS00:00 Introduction: The Challenge in Psychiatry00:34 Meet the Experts01:07 Understanding PTSD: Types and Subtypes04:47 Current Research and Innovations06:19 The Future of Psychiatry: Precision Medicine09:34 Case Study: Personalized Treatment Success11:33 Conclusion: The Path ForwardVisit our website for more Insights on Psychiatry.Watch this episode on YouTubeExecutive Producer: Jon Earle

Mason was nice enough to come back on the show after a nearly three year hiatus. We discuss the last three years and 2025, “The Year of the Lane.” It's always a pleasure speaking with him and I look forward to the next conversation. Enjoy!! https://lbr8.link/@Casualshooterpodcast  

Why is a broad approach that works with iPSC-derived cardiomyocytes so important to understanding molecular mechanisms underlying calcium homeostasis and arrhythmias? In this episode, Associate Editor Dr. Petra Kleinbongard (University of Duisburg-Essen) interviews author Dr. Katrin Streckfuss-Bömeke (University Medical Center Göttingen) and expert Dr. Melanie Paillard (Université Claude Bernard Lyon 1) about the new study by Ajmail et al. While arrhythmias in calcium transients are easy to detect by human perception, quantifying arrhythmias in a computer-readable manner is often difficult. To tackle the challenge, the authors developed an open-source program called Arrhythpy that quantifies and classifies confocal microscopy-based Fluo-4 Ca2+ transients to generate a measure of arrhythmia. What is unique about Arrhythpy is that it directly measures the shape and frequency of transients. The program includes two parts: frequency profiling using a method called wavelet transformation, and measuring transient peak shape using a method called autocorrelation function. After combining these measurements, Arrhythpy classifies each transient into one of 6 different subgroups. No specialty training is needed, and no specialized platforms are required to use Arrhythpy. The program can be used with different microscopes, cell types, and calcium dyes. What is the utility of Arrhythpy beyond the arrhythmia field? Listen now to find out.   Karim Ajmail, Charlotte Brand, Thomas Borchert, Benjamin Meder, Sabine Rebs, Katrin Streckfuss-Bömeke Arrhythpy: An Automated Tool to Quantify and Classify Arrhythmias in Ca2+ Transients of iPSC-Cardiomyocytes Am J Physiol Heart Circ Physiol, published September 15, 2025. DOI: 10.1152/ajpheart.00414.2025

Tony, Adriel, and Dustin are joined by Team Canada pistol shooter Taylor Reich to discuss the ISPC Pistol World Shoot 2025 that was put on in South Africa. We talk about the stages, competition, enduring the marathon, and dealing with “TIA”. Follow Taylor on Instagram @the.albertan. The post Episode 630 – Taylor Reich, IPSC Pistol World Shoot in South Africa appeared first on Slam Fire Radio.