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The goal of CPR is to keep the brain and vital organs perfused until return of spontaneous circulation (ROSC) is achieved.Post-arrest care and recovery are the final two links in the chain of survival.Identification of ROSC during CPR.Initial patient management goals after identifying ROSC.The patient's GCS/LOC should be evaluated to determine if targeted temperature management (TTM) is indicated.Patients that cannot obey simple commands should receive TTM for at least 24 hours.Recently published studies on TTM and ACLS's current standard.Monitoring the patient's core temperature during TTM.Patients can undergo EEG, CT, MRI, & PCI while receiving TTM.Good luck with your ACLS class!Links: Buy Me a Coffee at https://buymeacoffee.com/paultaylor Practice ECG rhythms at Dialed Medics - https://dialedmedics.com/Free Prescription Discount Card - Download your free drug discount card to save money on prescription medications for you and your pets: https://safemeds.vipPass ACLS Web Site - Episode archives & other ACLS-related podcasts: https://passacls.com@Pass-ACLS-Podcast on LinkedIn
Pelvic Floor Foundations Community Challenge!We just got started with a HUGE community on our Pelvic Floor Foundations course to move through it together this month! If you missed out on the Early Bird Discount, not to worry! As a podcast listener, you can use code OPTIMAL20 to still get the Early Bird price! Hundreds of people will be moving through this together over the next couple of weeks. There is even a private Instagram chat available to have your questions personally answered by Doc Jen! Come joint us!LMNT Electrolytes: Free Gift with Purchase!Fuel every system within the body and the brain with LMNT! Keep yourself hydrated on a cellular level by replenishing the sodium, potassium, and magnesium that our body needs for basic cellular processes like nerve signaling, smooth muscle contractions, unnecessary fatigue, aches and pain, brain fog, and recovery! Get a free gift with every purchase and try some new flavors as you stay hydrated! Get Your Free Gift!We think you'll love:Pelvic Floor FoundationsJen's InstagramDom's InstagramYouTube ChannelFor full show notes and resources go to https://jen.health/podcast/412What You'll Learn:2:45 Discussion on how overused diagnoses and imaging can be more harmful than helpful.3:22 Explaining that age-related changes on imaging are common and not always linked to pain.4:21 How people identify with diagnoses and the importance of not letting them define you.6:32 Research shows structural knee changes are common and not always related to pain; term “chondromalacia patella” is outdated.7:57 Studies show patellar alignment changes on MRI have minimal association with pain or function.9:53 A listener's story about anxiety from imaging results and the pitfalls of overemphasizing degenerative disc disease.11:51 Studies show high rates of disc herniation and degeneration in people without back pain.14:48 Rotator cuff tears are common on imaging, often found in people without shoulder pain.16:04 Routine imaging for shoulder pain is discouraged unless there are specific severe symptoms.19:20 “Shoulder impingement” is often misdiagnosed; structural changes don't always cause pain.21:01 Research shows surgery for impingement isn't always better than physical therapy.22:49 A listener avoided surgery and recovered from a severe disc herniation with time and rehab.
Join us on the latest episode, hosted by Jared S. Taylor!Our Guest: Dr. Danna Chung, Chief Medical Officer at Ezra.What you'll get out of this episode:Dr. Danna Chung's Diverse Medical Journey: From health policy and community clinics to innovative startups and AI-driven diagnostics.Personal Catalyst for Joining Ezra: A family cancer diagnosis led Dr. Chung to seek better early detection tools, ultimately connecting her to Ezra.The Power of Early Detection: Emphasizes how early cancer diagnosis, especially via total-body MRI, can dramatically improve survival rates.Ezra's Tech-Driven Approach: AI-assisted scoring, personalized follow-up, and longitudinal health tracking make their screening more effective and responsible.Strategic Growth with Function Health: Recent acquisition boosts combined offerings of lab testing and imaging, expanding access and affordability.To learn more about Ezra:Website http://ezra.com Linkedin https://www.linkedin.com/company/ezrainc/Our sponsors for this episode are:Sage Growth Partners https://www.sage-growth.com/Quantum Health https://www.quantum-health.com/Show and Host's Socials:Slice of HealthcareLinkedIn: https://www.linkedin.com/company/sliceofhealthcare/Jared S TaylorLinkedIn: https://www.linkedin.com/in/jaredstaylor/WHAT IS SLICE OF HEALTHCARE?The go-to site for digital health executive/provider interviews, technology updates, and industry news. Listed to in 65+ countries.
We're diving into some real talk about how to kickstart your career in radiology. Today, I'm answering your burning questions—everything from how to get into MRI tech without a fancy degree to the nitty-gritty on whether radiation is actually dangerous for us techs. Spoiler alert: it's not as scary as it sounds, and I'm here to clear up those misconceptions! We're also chatting about the money side of things—because let's be honest, who doesn't want to know which modalities can help pad the wallet? Whether you're a seasoned pro or just dipping your toes into the world of medical imaging, there's something here for everyone. So grab your favorite drink, kick back, and let's get this Q&A party started!If you've ever wondered what it's like to step into the world of radiology, you're in for a treat! In this lively episode, Chaundria takes us on a journey through the frequently asked questions that have been pouring in from her social media followers. With a casual tone that feels like a chat over coffee, she tackles everything from the pathways to becoming an MRI tech to the realities of radiation exposure for techs. One of the standout moments is her breakdown of the educational requirements—turns out, you don't need a fancy bachelor's degree to get started in this field! What's truly refreshing is how Chaundria blends her professional expertise with relatable anecdotes, ensuring that listeners feel both informed and entertained. For instance, she addresses concerns surrounding radiation safety with a mix of solid facts and a light-hearted approach, reassuring aspiring techs that the risk is considerably low with proper safety measures in place. Throughout the episode, there's a palpable sense of camaraderie as Chaundria encourages her audience to explore their options and think strategically about their careers. And just when you think the episode can't get any better, she dives into the money side of things, discussing which modalities might bring in more cash. Whether you're a seasoned pro or just curious about the field, this episode promises to be both enlightening and enjoyable, leaving listeners with a better grasp of radiology and perhaps even a few laughs along the way!Takeaways: To become an MRI tech in the US, you don't need a BSc; an associate's degree will do! Radiology offers various pathways, so think strategically about your education and certifications. Working in radiology does not significantly increase cancer risks; safety protocols are in place. If you want to switch modalities, explore additional certifications to boost your marketability. Before investing in a radiology program, check how your criminal record might affect licensing. Different radiology modalities offer varying salaries; research is key to knowing your worth. Links referenced in this episode:racheltheradiographer.comradiology, MRI technologist, medical imaging, radiologic technology, ARRT certification, radiologic sciences, healthcare careers, radiation safety, medical imaging education, radiology job market, cross-training modalities, radiation therapy, ultrasound technology, interventional radiology, dosimetry, healthcare certifications, radiology Q&A, radiology podcast, career advancement in radiology, medical imaging professions© 2025 A Couple of Rad Techs Podcast
Spryker's Chief Product Officer, Elena Leonova, discusses the Spryker Business Intelligence platform and how working with AWS as a strategic advisor unlocked deeper opportunities for transformative growth.Topics Include:Elena Leonova introduces Spryker as digital commerce platformSpryker focuses on sophisticated B2B commerce transactionsTraditional industries: manufacturing, industrial goods, med techCustomers sell complex equipment like MRI machines, tractorsProducts are custom-built to order through procurement processesExtensive negotiation and aftermarket servicing are requiredCompetitors focus on fashion, food - not complex equipmentSpryker exclusively hosted on AWS cloud infrastructureAWS partnership enables new capabilities and customer innovationBusiness intelligence tools and AI capabilities now availableRicoh example: global manufacturer of industrial-grade printersRicoh sells through dealers and distributors worldwideS-Diverse: new automotive software marketplace partnership platformConnects automotive manufacturers with embedded software producersSpryker Business Intelligence powered by Amazon QuickSight launchedCommerce becoming more intelligent than traditional repeat purchasesComplex equipment buyers don't purchase MRI machines weeklyPlatform provides insights into customer portal navigation patternsCombines commerce data with search, CRM, competitive intelligenceHelps merchants identify revenue optimization signals from noiseBusiness intelligence integrated directly within Spryker platformCustomers should evaluate platform's future scalability and flexibilityRevenue optimization requires understanding what metrics to improveEasy-to-use data analysis prevents information overload problemsQuickSight's GenAI capabilities enable faster executive decision-makingAWS partnership provided cost optimization and innovation confidenceElena initially viewed AWS as just hosting providerBuilding shared vision with AWS unlocked deeper collaborationAWS became trusted advisor for strategy and partnershipsGenerative AI enables multi-persona communication across customer typesParticipants:Elena Leonova – Chief Product Officer, SprykerSee how Amazon Web Services gives you the freedom to migrate, innovate, and scale your software company at https://aws.amazon.com/isv/
Send us a textIn this week's Journal Club, Ben and Daphna dive into the latest report from the American Academy of Pediatrics on the management of patent ductus arteriosus (PDA) in preterm infants. They dissect the nuances of prophylactic versus selective treatment, review recent meta-analyses, and explore why early intervention might not yield better outcomes despite effective PDA closure. They also break down new echocardiographic criteria for diagnosing a hemodynamically significant PDA and discuss the role of transcatheter procedures.The conversation then shifts to MRI timing and classification in neonatal encephalopathy, highlighting recent Canadian consensus recommendations for standardizing imaging protocols post-therapeutic hypothermia. The episode wraps up with a look at the TOHOP trial on permissive hypotension, challenging long-standing blood pressure treatment thresholds in preterm infants.Listeners will gain a pragmatic view of evolving clinical practices and research gaps in neonatal care, particularly for infants with PDA and hypoxic-ischemic encephalopathy. If you're looking to stay current on evidence-based recommendations without the fluff, this episode is for you. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
Dr. Grant Tinsley joins the discussion as the body composition expert.Myostatin is a key regulator of muscle growth.Wendy Whippete the most jacked muscled up dogThe concern of GLP-1 receptor agonists and muscle mass loss.Overview of Courage trial looking at semaglutide and trevogrumab and lean mass lossUpcoming Believe trial coming out (bimagrumab and semaglutide)Exercise remains crucial for muscle health and function.MRI data from SURPASS MRI provides new insights into muscle volume changes.The combination of medications may have varying effects on muscle mass.Caution is advised regarding the long-term effects of new drugs.Clinical benefits of medications often outweigh concerns about muscle loss.Future research will explore the synergy between exercise and medication.Other docs who lift podcasts with Dr. Grant:Tirzepatide muscle lossLean mass loss and GLP-1 meds
Dr Greg Zaharchuk joins Kristan and Bill for an in depth and educational discussion about Artificial Intelligence in MRI. Claim your Credit Here This MR iCast episode is supported by Bracco Diagnostics Inc. through an unrestricted educational grant.
What if the pain you've been told to ignore… was actually coming from your hips, your spine—or your immune system? In this deep-dive episode, Dr. Linda Bluestein is joined by Dr. Andrew Goldstein, an expert in sexual pain disorders, to unravel the misunderstood causes of vulvar and pelvic pain in people with EDS (Ehlers-Danlos Syndrome), MCAS (Mast Cell Activation Syndrome) , and POTS (Postural Orthostatic Tachycardia Syndrome). Dr. Goldstein reveals why the traditional diagnosis of “vulvodynia” might be missing the real problem, and how factors like labral tears, pudendal nerve compression, Tarlov cysts, pelvic organ prolapse, endometriosis, nerve proliferation, and mast cell disorders can all converge into debilitating pain—and be completely overlooked. He explains why pelvic floor physical therapy sometimes fails, when Botox is a game-changer, and how stigma and misinformation continue to prevent EDS patients from receiving proper care. If you've ever been told "it's all in your head"—this episode proves it's not. And it might be the roadmap you've been searching for. Takeaways: You might not feel hip pain at all—but your clitoris, rectum, or vulva will. A cyst that's left off your MRI report could be ruining your life. That pain during intimacy? It could be nerve sprouting—and it's not your fault. When physical therapy fails, it may not be the therapy's fault. He's performed 1,300+ surgeries. Here's how he decides if you really need one. Reference Links: Ep 130 with Dr. Goldstein: https://youtu.be/csiK_Zmb_hk Ep 116 with Dr. Feigenbaum: https://youtu.be/Uq4OrVa6deM https://www.gyncancer.org/ https://www.amazon.com/shop/hypermobilitymd/list/2LQLPARJY3CDS?ref_=aipsflist https://pubmed.ncbi.nlm.nih.gov/23875629/ https://pubmed.ncbi.nlm.nih.gov/23577645/ https://www.isswsh.org/ Want more Dr. Andrew Goldstein? Instagram: https://www.instagram.com/the.cvvd/ Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/. Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at https://www.bendybodiespodcast.com/. YOUR bendy body is our highest priority! Use this affiliate link for Algonot to get an extra 5% off your entire order: https://algonot.com/coupon/bendbod/ Connect with the HypermobilityMD: YouTube: youtube.com/@bendybodiespodcast Instagram: https://www.instagram.com/hypermobilitymd/ Facebook: https://www.facebook.com/BendyBodiesPodcast X: https://twitter.com/BluesteinLinda LinkedIn: https://www.linkedin.com/in/hypermobilitymd/ Newsletter: https://hypermobilitymd.substack.com/ Shop my Amazon store https://www.amazon.com/shop/hypermobilitymd Learn more about Human Content at http://www.human-content.com Podcast Advertising/Business Inquiries: sales@human-content.com Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links. Learn more about your ad choices. Visit megaphone.fm/adchoices
This week we're resharing a classic of Episode 455 when Steve tells us about his hilarious MRI experience while we enjoy Harp Lager and Guinness Extra Stout. Cheers Big Ears!#beerclub #beerclubpodcast #bestnewpodcast #whatsinthefridge #WITF #beeroftheweek #notforthetaintofheart #newandnoteworthypodcast #bestpodcast #drinklocal #craftbeer #beertasting #youtubepodcast #spotifypodcast #applepodcast #beeradvocate #drinklocal #beer #beerreviews #guiness #harp
What if the pain you've been told to ignore… was actually coming from your hips, your spine—or your immune system? In this deep-dive episode, Dr. Linda Bluestein is joined by Dr. Andrew Goldstein, an expert in sexual pain disorders, to unravel the misunderstood causes of vulvar and pelvic pain in people with EDS (Ehlers-Danlos Syndrome), MCAS (Mast Cell Activation Syndrome) , and POTS (Postural Orthostatic Tachycardia Syndrome). Dr. Goldstein reveals why the traditional diagnosis of “vulvodynia” might be missing the real problem, and how factors like labral tears, pudendal nerve compression, Tarlov cysts, pelvic organ prolapse, endometriosis, nerve proliferation, and mast cell disorders can all converge into debilitating pain—and be completely overlooked. He explains why pelvic floor physical therapy sometimes fails, when Botox is a game-changer, and how stigma and misinformation continue to prevent EDS patients from receiving proper care. If you've ever been told "it's all in your head"—this episode proves it's not. And it might be the roadmap you've been searching for. Takeaways: You might not feel hip pain at all—but your clitoris, rectum, or vulva will. A cyst that's left off your MRI report could be ruining your life. That pain during intimacy? It could be nerve sprouting—and it's not your fault. When physical therapy fails, it may not be the therapy's fault. He's performed 1,300+ surgeries. Here's how he decides if you really need one. Reference Links: Ep 130 with Dr. Goldstein: https://youtu.be/csiK_Zmb_hk Ep 116 with Dr. Feigenbaum: https://youtu.be/Uq4OrVa6deM https://www.gyncancer.org/ https://www.amazon.com/shop/hypermobilitymd/list/2LQLPARJY3CDS?ref_=aipsflist https://pubmed.ncbi.nlm.nih.gov/23875629/ https://pubmed.ncbi.nlm.nih.gov/23577645/ https://www.isswsh.org/ Want more Dr. Andrew Goldstein? Instagram: https://www.instagram.com/the.cvvd/ Connect with YOUR Hypermobility Specialist, Dr. Linda Bluestein, MD at https://www.hypermobilitymd.com/. Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at https://www.bendybodiespodcast.com/. YOUR bendy body is our highest priority! Use this affiliate link for Algonot to get an extra 5% off your entire order: https://algonot.com/coupon/bendbod/ Connect with the HypermobilityMD: YouTube: youtube.com/@bendybodiespodcast Instagram: https://www.instagram.com/hypermobilitymd/ Facebook: https://www.facebook.com/BendyBodiesPodcast X: https://twitter.com/BluesteinLinda LinkedIn: https://www.linkedin.com/in/hypermobilitymd/ Newsletter: https://hypermobilitymd.substack.com/ Shop my Amazon store https://www.amazon.com/shop/hypermobilitymd Learn more about Human Content at http://www.human-content.com Podcast Advertising/Business Inquiries: sales@human-content.com Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links. Learn more about your ad choices. Visit megaphone.fm/adchoices
The Strong[HER] Way | non diet approach, mindset coaching, lifestyle advice
Send us a textIn this episode of The StrongHer Way, Alisha Carlson sits down with renowned clinical neuropsychologist Dr. Alina Fong to unpack the complexities of brain health and how traumatic brain injuries—both emotional and physical—impact behavior, cognition, and overall wellness. They dive deep into the cutting-edge science of neuropsychology, explore how functional MRI is revolutionizing the diagnosis and treatment of concussion symptoms, and spotlight the critical importance of individualized care in today's healthcare model.Dr. Fong shares her innovative Brain Boot Camp program, which uses cognitive therapy, nutrition, exercise, and sleep optimization to restore brain function and improve quality of life. This conversation challenges the outdated, one-size-fits-all approach to healthcare and introduces a holistic treatment model that empowers patients—especially women—to reclaim their health and vitality.Whether you're navigating your own brain fog, healing from trauma, or looking to optimize your mind for high performance, this episode offers tangible strategies rooted in science and backed by years of clinical practice.What You'll Learn in This Episode:How brain structures affect behavior, personality, and decision-makingThe link between emotional trauma and brain functionWhy concussions often go undiagnosed—and what signs to look forThe power of functional MRI in diagnosing and tracking brain injuriesHow neurohacking practices like sleep, movement, and learning new skills improve brain functionWhy women's health must include brain-focused, individualized careThe role of nutrition and exercise in cognitive recovery and brain optimizationHow community and connection support long-term wellnessThis episode is perfect for you if:You've struggled with brain fog, fatigue, or memory issuesYou want a more integrated approach to healthcareYou're curious about how to optimize brain health without medicationYou're a high-achieving woman looking for holistic wellness strategies
Spontaneous intracranial hypotension reflects a disruption of the normal continuous production, circulation, and reabsorption of CSF. Diagnosis requires the recognition of common and uncommon presentations, careful selection and scrutiny of brain and spine imaging, and, frequently, referral to specialist centers. In this episode, Gordon Smith, MD, FAAN speaks with Jill C. Rau, MD, PhD, author of the article “Clinical Features and Diagnosis of Spontaneous Intracranial Hypotension” in the Continuum® June 2025 Disorders of CSF Dynamics issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Rau is an assistant professor of clinical neurology at the University of Arizona, School of Medicine-Phoenix in Phoenix, Arizona. Additional Resources Read the article: continuumjournal.com Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Full episode transcript available here Interview with Jill Rau, MD Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Smith: This is Dr Gordon Smith. Today I'm interviewing Dr Jill Rau about her article on clinical features and diagnosis of spontaneous intracranial hypotension, which she wrote with Dr Jeremy Cutsworth-Gregory from the Mayo Clinic. This article appears in the 2025 Continuum issue on disorders of CSF dynamics. I'm really excited to welcome you to the Continuum podcast. Maybe you can start by just telling our listeners a little bit about yourself? Dr Rau: Hi, thanks for having me. I'm really honored to be here, and I really enjoyed writing the paper with Dr Cutsforth-Gregory. I hope you guys enjoy it. I am the director of headache medicine at the Baba Bay Neuroscience Institute at Honor Health in Scottsdale, Arizona. I'm also currently the chair of the special interest group in CSF Dynamics at the American Headache Society, and I've had a special interest in this field since I first watched Dr Linda Gray speak at a conference where she talked about spinal CSF leaks and their different presentations. And they were so different than what I had been taught in residency. They're not just the post-LP headache. They have such a wide variety of presentations and how devastating they can be, and how much impact there is on someone's life when you find it and fix it. And I've been super interested in the field and involved in research since that time. And, yeah. Love it. Dr Smith: Well, thanks for sharing your story. And as I reflected on our conversation ahead of time and have been thinking about this issue… this is a cool topic, and every time I read one of these manuscripts and have the opportunity to speak with one of the authors, I learn a ton, because this was something that wasn't even on the radar when I trained back in the 1800's. So, really looking forward to the conversation. I wonder if you could really briefly just summarize or remind for everyone the normal physiology about CSF dynamics, you know, production, absorption, and so forth? Dr Rau: So, the CSF is the fluid that surrounds the brain and the spinal cord, and it's contained by the dura, which is like a canvas or a sac that covers that whole brain and spinal cord. And within the ventricles of the brain, the choroid plexus produce CSF. It's constantly producing and then being reabsorbed by the arachnoid granulations and pushed into the venous space, the cerebral sinuses, venous sinuses. And also some absorption and push into the lymphatics that we've just learned about in the past year. This is kind of new data coming out, so always learning more and more about CSF, but we know that it bathes the brain and the spinal cord, helps keep some buoyancy of the brain as well as pushing nutrients in and pulling out metabolic waste. And it sort of keeps the brain in the state of homeostasis that's happy. And so, when there's a disruption of that flow and the amount of fluid there, that disrupts that, that can cause lots of different symptoms and problems for people. Dr Smith: One of the many new things I learned is that even the name of this---spontaneous intracranial hypotension---is misleading. And I think this is clinically relevant, as we'll probably get to in a moment, but can you talk a little bit about this? Is this really like a pressure disorder or a volume disorder? Dr Rau: Yeah. It's almost certainly a volume disorder. We do see in some people that they have low pressure, and it's still part of the diagnostic criteria. But it's there because if you have a low pressure, if you measure an opening pressure and it's below six, if you're measuring it in the spine in the right place, then you have indication that there's low volume. But there's over 50% of people's opening pressure who have a spinal CSF leak, have all the symptoms and can be fixed. So, they have normal pressure in 50% of the people. So, it is an inaccurate term, hypotension, but it was originally discovered because of the thought that it was a low-pressure situation. Some of the findings would suggest low pressure, but ultimately, we are pretty sure it's a low-volume condition. Dr Smith: Another new thing that I learned that really blew me away is how bad this can be. I did a podcast with Mark Burish about cluster, and I was reminded many cluster patients are pushed to the point of suicidal ideation or committing suicide by the severity of pain. And this sounds like for many patients it's equally severe. Can you maybe paint a picture for our listeners why this is so clinically important? Dr Rau: A large number of people, even people who are known to have leaks because they've had them before or they've releaked, they have a lot of brain fog and cognitive impairment. They often have severe headaches when they're upright. So, orthostatic headache is probably the number one most common symptom, and those headaches are one of the worst headaches out there. When people stand up, their fluid is not supporting the brain and there's an intense amount of pain. And so, they spend a large portion of their lives horizontal. And there's associated symptoms with that, it's not just headache pain and brain fog. There's neck pain. There's often subsequent disorders that accompany this, like partial orthostatic tachycardia syndrome. We don't know if that's because of deconditioning or an actual sequela of the disease, but it's a frequent comorbidity. We have patients that have extreme dizziness with their symptoms, but many patients are limited to hours, if that, upright per day, combined, total. And so they live their lives, often, just in the dark, lots of photophobia, sensitive to the light, really unable to function. It's also very hard to find and so underrecognized that a lot of patients, especially if they don't have that really clinical symptom of orthostatic headache. So, it's often missed. So, they're just debilitated. You know, treatments don't work because it's not a migraine and it's not a typical headache. It's a mechanical issue as well as a metabolic issue and not found, not a lot helps it. Dr Smith: So, you know, I have always thought about this as really primarily an orthostatic symptom. I wonder if you can talk about the complexity of this; in particular, kind of how this evolves over time, because it's not quite that simple. And maybe in doing so, you can give our listeners some pearls on when they should be thinking about this disorder? Dr Rau: A large portion of people do have headache with spinal CSF leak, in particular, spontaneous intracranial hypertension- hypotension, excuse me. And that's something to be thought about, is that there are spontaneous conditions where people have either rupture of the dural sac, or an erosion of the dural sac, or a development of a connection between the dura and the venous system. And that is taking away or allowing CSF to escape. In these instances that patients have spontaneous, there may be a different presentation than if they have, like, a postdural puncture or a chronic traumatic or iatrogenic leak. And we're not sure of that yet, but we're looking into that. Still, the largest presentation is headache, and orthostatic headache is very dominant in the headache realm. But over time, patients' brains can compensate for that lack of CSF and start overproducing---or at least we think that's probably what's happening. And you may see a reduction in the orthostatic symptoms over time, and you may see an improvement in the radiographic findings. So, there are some interesting papers that have been published that look at these changes over time, and we do see that sometimes within that first three to four months; this is the most common time to see that change. Other patients may worsen. You may actually see someone going from looking sort of normal radiographically to developing more of a SIH-type of picture on the brain. And so it's not predictable which patients have gone from orthostatic to improvement or the other way around, both radiographically and clinically. So, it can be quite difficult to tell. So, for me, if I have a patient that comes to me and they're struggling with headache… if it's orthostatic, very clearly orthostatic: I lay down, I get considerably better or my headache completely goes away. And then when I stand up, it comes on relatively quickly, within an hour. And sometimes it's a worsening-throughout-the-day type of thing, it's lowest in the morning and it worsens throughout the day. These are the times that it's most obvious to think about CSF leak. Especially if that headache onset relatively suddenly, if it onset after a small trauma. Like I've had patients that say, you know, I was doing yoga and I did some twists and I felt kind of a pop. And then I've had this headache that is horrible when I'm upright but is better when I lay down ever since, you know, since that time. That's kind of a very classic presentation of spinal CSF leak or spontaneous intracranial hypotension. Maybe a less common presentation would be someone who comes to you, they've had a persistent headache for a couple years, they kind of remember it started in March of a couple years ago, but they don't know. Maybe it's, you know, it's a little better when they lay down. It may be a little worse when they're up moving around, but so is migraine, and it's a migrainous headache. But they've tried every migraine drug you can think of. Nothing is responding, nothing helps. I'm always looking at patients who are new daily, persistent headaches and patients who aren't responding to meds even if it's not new daily, but they have just barely any response. I will always go back and examine their brain imaging and get full spine to make sure I'm not missing. And you can never be 100% sure, but it's always good to consider those patients to the best of your ability, if that- have that in the back of your mind. Dr Smith: So obviously, goes without saying, this is something people need to have on their radar and think about. And then we'll talk more about diagnostic tools here in a second. But how common is this? If you're a headache doc, you see a lot of patients who have intractable headaches. And how often do you see this in your headache practice? Now you're- this is your thing, so probably a little more than others, but, you know, how common will someone who sees a lot of headache encounter these patients? Dr Rau: If you see a lot of headache, I mean, currently the thought is it's about 5 in 100,000. That was from a study before we were finding CSF venous fistulas. I think a lot of us think it's more common than that, but it's not super common. We don't have good estimates, but I would guess between 5 and 10 for 100,000 persons, not “persons who come to a tertiary headache clinic with intractable headaches”. So, it's hard to gauge how frequent it is, but I would say it's considerably more frequent than we currently think it is. There's still a group of people with orthostatic headaches that we can't find leaks on; that, once you treat other things that can cause or look for other things that can cause orthostatic headaches. So, there may be even still a pathophysiology out there that is still a leak type. Before 2014, we didn't even know about CSF venous fistulas. And now here we are; like, 50% of them are CSF venous fistulas. So, you know, we're still in a huge learning curve right now. Dr Smith: So, I definitely want to talk about the fistulas in a second. But before moving on, one of the things that I found really interesting is the wide spectrum of clinical phenotype. And we obviously don't have a lot of time to get into all of these different ones, but the one that I was hoping you might talk about---and there's a really great case, and you're on bunch of great case, a great case of this---is brain sagging dementia, not a term I've used before. Can you really briefly just tell our listeners about that, because that's a really interesting story and a great case in your article? Dr Rau: Yeah. So, brain sag dementia is a… almost like an extreme version of a spontaneous intracranial hypotension. Where there is clear brain sag in the imaging---so that's helpful---but the patients present kind of like a frontotemporal dementia. And when this was first started to being determined, you could turn the patient into Trendelenburg, and sometimes they would improve. There are some practitioners that have introduced fluid into the thecal sac and had temporary improvement. Patching has improvement, then they leak again, sometimes not. But the clinical changes with this have been pretty tremendous to be able to identify that that's a real thing. And in some cases, out of Cedars Sinai, you know, who does a lot of the best research in this, they've had lots of cases where they can't find the leak, but there's clear brain sag that fits with our clinical picture of CSF leaks. So, we're on a learning curve. But yeah, this- they really present. They have disinhibition and cognitive impairment that is very similar to frontotemporal dementia. Dr Smith: Well, so let's talk about what causes this. You mentioned CSF venous fistulas. I mean, that was reported now just over a decade ago, it's pretty amazing. That accounts for about half of cases, if I understand correctly. What are the other causes? And then we'll talk more about therapy in a minute, but what causes this? Dr Rau: So, within the realm of spontaneous, you know, we say it's spontaneous. But the spontaneous cases we account for, they can be tears in the dura, which are usually sort of lateral tears in the dura. They can be little places that rubbed a hole, often on an osteophyte from the spine. They can come from these spinal diverticuli. So, I always describe it to my patients like those balls that have mesh and squishy, and you squeeze them in the- through the mesh, there's the extra little bubbling out. If you think of like the dura bubbling, out in some cases, through the framing of the spine, right where the spinal nerve roots come out, they should poke out like wires from the dura. But in many cases they poke out with this extra dura surrounding them, and we call that spinal diverticuli. And if you imagine like the weakening of where you squeeze that, you know, balloon through your fingers, in those locations, that's a very common place to find a CSF leak, and you can imagine that the integrity of the dura there may be less than it would be if it were not being expanded in that direction. And that's often the most common place we see these CSF venous fistulas. So, you can get minor traumas; like I said, it can be spontaneous, like someone just develops a leak one day. It can be rubbed off, and it can be a development of a connection between the dura and the venous system. There are also iatrogenic causes, but we don't consider them spontaneous. But when you're considering your patients for spontaneous cases, you should consider if they've ever had chronic---even long, long time ago---had any spinal implementation, procedures near the spine, spinal injections, LPs in the past, and especially women who've had epidurals in pregnancy. Dr Smith: All right, so we see a patient, positional severe headache, who meets the clinical criteria. Next step, MRI scan? Dr Rau: Yeah. So, the first thing is always to get the brain MRI with and without contrast. Most places will have a SIH or a spinal CSF leak protocol, but you should get contrast because one of the most pathognomonic findings on brain MRI is that smooth diffuse dural enhancement. And that's a really fantastic thing when you find it, because it's kind of a slam dunk. If you find it, then you will see other findings. It almost never exists alone. But if you see that, it's pretty much a spinal CSF leak. But you're also looking for subdural collections, any indication of brain sag. We do have these new algorithms that have come out in the past couple of years that are helpful. They're not exclusionary---you can have negative findings on the brain and still have spinal CSF leak---but the brain MRI is extremely helpful. If it's positive for the findings, it really does help you nudge you in the direction of further investigations and treatments. Dr Smith: And what about those further investigations and treatments, right? So, you see that there's findings consistent with low pressure, and I guess I should say low intracranial CSF volume. Be that as it may, what's the next step after that? Dr Rau: Depends on where you are and what you can do. I almost always will get a full spine MRI: so, C spine, T spine, and L spine separately. Not, you know, we don't want it all in one picture, because we want to get the full view. And you want to get that with at least T2 highly- heavily T2 weighted with fat saturation in at least the sagittal and axial planes. It's really helpful if you can get it in the coronal planes, but we have to have- often have good talks with your radiologist to get the coronal plane. I spoke about the spinal diverticuli earlier, and I want to clarify a little bit of something. The coronal image will show those really nicely. It's interesting, but 44% of people have those. So just having the spinal diverticuli does not indicate that you have a leak. But if you have a lot of those, there may be more likelihood of having leak than if you don't have any of those. So, I will get all of those and I will look at them myself, but I've been looking at them myself for a long time. But a lot of radiologists in community hospitals, especially not- nonneuroradiologists, but even neuroradiologists, this isn't something that's that everybody's been educated about, and we've been learning so much about it so rapidly in the past ten years. It's not easy to do and it's often missed. And if it's not protocoled properly, the fat saturation's not there, it's very hard to see… you can have a leak and not see it. Even the best people, like- it's not always something that's visible. And these CSF venous fistulas that we talked about are never visible on normal MRI imaging. Nonetheless, I will run those because if I can find a leak---and 90% of the ones that are found on MRI imaging are in the thoracic spine. So that's where I spend the most of my time looking. But if you find it, that's another thing to take to your team to say, hey, look, here it is, let's try and do this, or, let's try and do that, or, I've got more evidence. And there are other findings on the spine; not just the leak, but other findings, sometimes, you can see on spine that maybe help you push you towards, yes, this is probably a leak versus not. Dr Smith: So, your article has a lot of great examples and detail about kind of advanced imaging to, like, find the fistula and what not. I guess I'm thinking most of our listeners are probably practicing in a location where they don't have a team that really focuses on that. So, let's say we do the imaging of the spine and you don't find a clear cause. Is the next step to just do a blood patch? Do you send them to someone like you? What's the practical next step? Dr Rau: Yeah, if your- regardless of whether you find a leak or not, if your clinical acumen is such that you think this patient has a leak or I've treated them for everything else and it's not working and I have at least a high enough suspicion that I think the risk of getting a patch is lower than the benefit that if they got a patch and it worked, I do send my patients for non-directed blood patches, because it currently does take a long time to get them to a center that can do CT myelograms or any kind of advanced imaging to look for sort of a CSF venous fistula or to get treated outside of a nondirected patch. You know, sometimes nondirected patches are beneficial for patients, and there's some good papers out there that sort of explain the low risks of doing these if done properly versus the extreme benefit for patients when it works. And, I mean, I can't tell you how many people come in and tell me how their lives are changed because they finally got a blood patch. And sometimes it works. And it's life-changing for those people. You know, they go back to work. They can interact with their kids again. Before, they didn't know what was wrong, just had this headache that started. So it's worth doing if you have a strong clinical suspicion. Dr Smith: Yeah. I mean, that was great. And, you know, to go back to where we began, this is severe. It's something like 60% of patients with this problem have thought about suicide, right? And you take this patient and cure the problem. I feel really empowered having read the article and talked to you today. And so, I'm ready to go out and look for this. Thank you so much for a really engaging conversation. This has been terrific. Dr Rau: Thank you. I appreciate it. I enjoyed being here. Dr Smith: Again, today I've been interviewing Dr Jill Rau about her article on clinical features and diagnosis of spontaneous intracranial hypotension---which I guess I should say hypovolemia after having talked to you---which she wrote with Dr Jeremy Cutsworth-Gregory. This article appears in the most recent issue of Continuum on disorders of CSF dynamics. Please be sure to check out Continuum Audio episodes from this really interesting issue and other interesting issues. And thank you, our listeners, again for listening to us today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.
On June 3, 2025, the Cincinnati Reds snapped the Milwaukee Brewers' eight-game winning streak with a 4-2 victory at Great American Ball Park, delivering a much-needed boost to their season. The Reds, struggling with a 29-32 record and fourth place in the NL Central, showcased resilience against a red-hot Brewers team that had dominated them in recent matchups, winning 18 of their last 22 games at Cincinnati. This win, highlighted by strong pitching and timely hitting, offered a glimmer of hope for a Reds squad looking to turn their season around under manager Terry Francona. The game's turning point came early with Reds ace Hunter Greene on the mound. Despite concerns about his right groin, which required an MRI post-game, Greene battled through five innings, allowing just two runs. His performance was gritty, throwing 114 pitches— the most by any MLB pitcher this year— and striking out key Brewers hitters. However, discomfort in the fifth inning forced his early exit, leaving the bullpen to preserve the lead. The Reds' relievers, often a weak point, stepped up, with the bullpen delivering dominant frames to secure the win. Offensively, the Reds struck early, jumping to a 2-0 lead in the first inning. While their bats went quiet afterward, struggling to capitalize on opportunities—a recurring issue this season—they added crucial runs late to seal the game. Santiago Espinal and TJ Friedl contributed key hits, while Elly De La Cruz, despite personal grief following his sister's passing, showed heart by playing and adding to the team's effort. The Reds' offense, described as “feast or famine” in 2025, leaned on just enough production to outlast Milwaukee's Christian Yelich, who homered but couldn't spark a comeback. This victory was more than a single game for Cincinnati. It halted a slide that saw them lose momentum after a promising April. With injuries piling up—outfielder Austin Hays landed on the injured list with a foot contusion—and trade deadline decisions looming, the Reds needed a statement win. While Greene's health remains a concern, the team's ability to rally against a division rival suggests potential for a second-half surge. For Reds fans, last night's win was a reminder of the team's talent and tenacity, even in a challenging season.
Send us a textAmanda Phillips never imagined her lifelong battle with Crohn's disease would transform into a business helping other people living with chronic illnesses. But after decades of unexplained stomach pains, missed diagnoses, and learning to navigate life with IBD, that's exactly what happened.Amanda takes us through her journey from childhood stomach aches dismissed as "just constipation" to her eventual diagnosis at 17. We explore how she learned to identify her personal flare triggers—stress and GI bugs being the major culprits—and the profound anxiety this created around situations most people take for granted, like commuting to work or being around sick family members.The pandemic became an unexpected turning point in Amanda's health journey. Working remotely eliminated the bathroom-related stress of her daily commute. When her company pushed employees back to the office, Amanda fought for accommodations, facing frustrating resistance from HR despite documentation showing remote work improved her health and performance.The birth of Be Well came during a February 2022 hospitalization, when Amanda found herself freezing in a standard hospital gown. Looking around at the medical wear available, she thought, "I can do better than this." What makes Amanda's approach unique is her commitment to meaningful design. Every Be Well product—from symptom tracking journals to discreet pill holders to comfort items with inspirational quotes—comes from lived experience and continuous customer feedback with a focus on prioritizing patient comfort, dignity, and practicality. Now she's expanding into new territory with hospital gowns, non-metal MRI hoodies, and more innovations. Whether you're living with chronic illness or supporting someone who is, this episode offers inspiration in turning personal challenges into purpose and creating solutions that truly understand patient needs.Links: Link to the BeWell websiteLink to BroGloInformation about IBD and work- Crohn's & Colitis Foundation- USAMy guest co-host, Stacey Calabro's episodeLet's get social!!Follow us on Instagram!Follow us on Facebook!Follow us on Twitter!
This week on Heart Doc VIP, Dr. Joel Kahn explores a groundbreaking new topic: predicting dementia before symptoms appear. Would you want to know if your brain health is at risk—even while your memory still feels sharp? New blood tests may offer insight, and the results could open the door to preventative strategies involving diet, sleep, exercise, and targeted supplements. Dr. Kahn also tackles several fast facts in the "hot topics" section: Is there a link between cell phone use and prostate cancer? Can EMF exposure during MRI scans contribute to disease? Does sugar intake—especially from sodas—actually increase your risk for type 2 diabetes? Plus, thanks to this week's sponsor, Igennus, whose chewable Vitamin C supplement is available now with the discount code DRKAHN. Tune in for practical tips, intriguing science, and the power of knowing—before it's too late.
In this episode, host Dr. Reni Butler speaks with Dr. Kalina Slavkova, Dr. Ruya Kang, Dr. Despina Kontos, and Dr. Habib Rahbar about their groundbreaking research using MRI-based radiomic features to improve risk stratification in ductal carcinoma in situ (DCIS). The discussion explores how combining clinical data, imaging, and AI-driven analysis could help personalize treatment and reduce overtreatment in breast cancer care. MRI-based Radiomic Features for Risk Stratification of Ductal Carcinoma in Situ in a Multicenter Setting (ECOG-ACRIN E4112 Trial). Slavkova and Kang et al. Radiology 2025; 315(1):e241628.
Are we entering a new era of prostate cancer testing? In this episode, Dr. Geo speaks with Dr. Jeffrey Tosoian—urologist, researcher, and lead author behind MyProstateScore 2.0 (MPS 2.0)—a cutting-edge urine test that may outperform PSA and even MRI in identifying clinically significant prostate cancer.
In this powerful and information-rich episode, Dr. Nasha Winters sits down with detox expert and RemedyLink founder Spencer Feldman to unravel the complexities of modern toxicity and detoxification. With over 20 years of experience in formulating novel detox protocols and delivery systems, Spencer shares a science-backed, deeply nuanced approach to helping the body eliminate harmful substances—ranging from heavy metals and forever chemicals to spike protein remnants and gadolinium toxicity.What starts as a discussion about the need for detoxification in our increasingly toxic world evolves into a compelling breakdown of how detox pathways really function, why certain therapies fail, and how to navigate these challenges using precise, phase-based support. Plus, Spencer gives us a rare look into his off-grid lifestyle, revealing the daily rituals and biohacks he uses to optimize his health and circadian rhythm.
This week the Maier's get together on a Monday afternoon to discuss: back alley action, MRI, anxiety, maturing, land acknowledgment, Justin returns, Girl Guides, SOW, and performance anxiety. Reach Us: @kmaemaier @chrismaierbc @hwywhoney hwywhoney@gmail.com
How do you know if getting a PSA test is truly beneficial or potentially harmful?In this episode, Dr. Stephen Petteruti sheds light on the PSA test, unraveling common myths and highlighting why traditional treatments often pose serious risks without clear benefits. He emphasizes the value of gentler, more targeted methods like MRI scans and the prostate health index, helping you protect your health without unnecessary harm.Rather than rushing into aggressive treatments, Dr. Stephen encourages a thoughtful approach focused on maintaining vitality and proactive health management.Listen to this insightful episode and gain valuable insights into navigating decisions around PSA testing and prostate health. What Is Prostate-Specific Antigen (PSA) Test & Should You Get One?Enjoy the podcast? Subscribe and leave a 5-star review!Dr. Stephen Petteruti is a leading Functional Medicine Physician dedicated to enhancing vitality by addressing health at a cellular level. Combining the best of conventional medicine with advancements in cellular biology, he offers a patient-centered approach through his practice, Intellectual Medicine 120. A seasoned speaker and educator, he has lectured at prestigious conferences like A4M and ACAM, sharing his expertise on anti-aging. His innovative methods include concierge medicine and non-invasive anti-aging treatments, empowering patients to live longer, healthier lives.Website: www.intellectualmedicine.com YouTube: https://www.youtube.com/@dr.stephenpetteruti LinkedIn: https://www.linkedin.com/in/drstephenpetteruti/ Instagram: instagram.com/dr.stephenpetteruti Disclaimer: The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.
After yesterday's warm weather, things cool off today with a high of just 72° and some showers & thunderstorms throughout the area. We let you know what's new on New Release Tuesday and we talked to Grant Bilse from the Wisco Sports show. In the news this morning, the horrible killing of Jonathan Joss yesterday, Italy's Mount Etna erupted, one of the Manson Family murderers has been released on parole, a pet zebra escaped in Tennessee & caused some chaos, and the DNR issued another air quality warning because of the Canadian wildfires. In sports, the Brewers extended their winning streak to eight games with a victory over the Reds last night, the NHL finals begin tomorrow night and the NBA finals begin on Thursday. Elsewhere in sports, Saquon Barkley is on the cover of the new Madden game, the Lions center has retired, Journalism is set to run at the Belmont Stakes, and the Mariners are going to retire Randy Johnson's number. We talked about some money-saving "hacks" that might be costing you more than you know…and a new filter on Tinder to weed out the short dudes. Country legend George Strait recently gifted a new home to a Military Veteran, and a woman discovered she had a tumor thanks to a mistake made by an MRI technician. In today's edition of "Bad News with Happy Music", we had stories about a guy trying to get a bunch of venomous snakes on a plane, a woman who strangled her roommate because of dirty dishes, a woman in Louisiana who destroyed a car with syrup & sugar, and the latest on Bonnie Blue.See omnystudio.com/listener for privacy information.
It's time! The Royals are promoting Jac Caglianone (2:15)! ... Spencer Schwellenbach had 11 strikeouts in back-to-back starts (8:29). ... Jesus Luzardo and Brandon Pfaadt got bombed this weekend (12:44). ... News (19:58): Corbin Burnes will have an MRI on his elbow. ... We had some other prospect promotions, including Cole Young to the Mariners and Jacob Melton to the Astros (31:32). ... Carlos Correa is hitting well since coming off the IL (43:40). ... Zebby Matthews had a mixed start this weekend (49:27). ... Start or sit these pitchers (55:01). ... We wrap up with leftovers, bullpens and streamers (58:46). Fantasy Baseball Today is available for free on the Audacy app as well as Apple Podcasts, Spotify and wherever else you listen to podcasts. Subscribe to our YouTube channel: youtube.com/FantasyBaseballToday Download and Follow Fantasy Baseball Today on Spotify: https://sptfy.com/QiKv Get awesome Fantasy Baseball Today merch here: http://bit.ly/3y8dUqi Follow FBT on TikTok: https://www.tiktok.com/@fbtpod?_t=8WyMkPdKOJ1&_r=1 Follow our FBT team on Twitter: @FBTPod, @CPTowers @CBSScottWhite, @Roto_Frank Join our Facebook group at https://www.facebook.com/groups/fantasybaseballtoday Sign up for the FBT Newsletter at https://www.cbssports.com/newsletters/fantasy-baseball-today/ For more fantasy baseball coverage from CBS Sports, visit https://www.cbssports.com/fantasy/baseball/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ You can listen to Fantasy Baseball Today on your smart speakers! Simply say "Alexa, play the latest episode of the Fantasy Baseball Today podcast" or "Hey Google, play the latest episode of the Fantasy Baseball Today podcast." To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
A routine spa day flips paranormal when the masseuse pauses mid-rub, senses hidden fears about a looming MRI, and calmly announces she's psychic. Details spill out about a friend killed in a car crash, a family line of “seers,” and a gift the client insists she doesn't have—until every light in the room dies without anyone near the switch. Back home, dread pools in the dining room, whispers echo through empty halls, and a sister casually confirms the family's second sight. This is a daily EXTRA from The Grave Talks. Grave Confessions is an extra daily dose of true paranormal ghost stories told by the people who survived them! If you have a Grave Confession, Call it in 24/7 at 1-888-GHOST-13 (1-888-446-7813) Subscribe to get all of our true ghost stories EVERY DAY! Visit http://www.thegravetalks.com Please support us on Patreon and get access to our AD-FREE ARCHIVE, ADVANCE EPISODES & MORE at http://www.patreon.com/thegravetalks
The Nats four game win streak was snapped in Sunday afternoon's 3-1 loss in Arizona. Mark (From Phoenix) & Al open with DBacks Ace Corbin Burnes leaving the game in the top of the 5th due to a potential elbow injury. Burnes will have a MRI on Monday just a few minths after signing a 6-year/ $210M deal.(07:30) James Wood was hitless, but both team doubles came from the new guys in Robert Hassell III & Daylen Lile. Nathaniel Lowe's RBI single in the 5th was the only source of offense.(09:30) Mitchell Parker struggled yet again the bottom of the 1st and all three Arizona runs came in that frame. Should the team experiment going with an Opener in future Parker starts to try and right the ship? Parker's ERA in the 1st inning is astonishingly over 10.50 this season and roughly 3.50 in all other innings. (19:45) The three relievers used combined for three scoreless frames. Eduardo Salazar escaped a jam in the bottom of the 6th his first appearance since he replaced Jorge Lopez on the roster.(22:00) The Cubs come to D.C. on Tuesday and are tied for the best record in the NL. The hosts note that Chicago is far ahead of Washington despite the two franchises beginning their rebuilds at the exact same time in the summer of 2021.(25:05) If the Nats are in the Wild Card hunt ahead of the Trade Deadline, will they be buyers? The Deadline this season is on Thursday July 31st at 6PM.
The Royals are promoting top prospect Jac Caglianone! Corbin Burnes will have an MRI on his elbow. It turns out Yordan Alvarez is dealing with a fracture in his hand. The Mariners also promoted Cole Young. Fantasy Baseball Today Express is available for free on the Audacy app as well as Apple Podcasts, Spotify and wherever else you listen to podcasts. Get Fantasy Baseball Today merch here: http://bit.ly/3y8dUqi Follow FBT on TikTok: https://www.tiktok.com/@fbtpod?_t=8WyMkPdKOJ1&_r=1 Follow our FBT team on Twitter: @FBTPod, @CPTowers @CBSScottWhite, @Roto_Frank Join our Facebook group at https://www.facebook.com/groups/fantasybaseballtoday Sign up for the FBT Newsletter at https://www.cbssports.com/newsletters/fantasy-baseball-today/ For more fantasy baseball coverage from CBS Sports, visit https://www.cbssports.com/fantasy/baseball/ To hear more from the CBS Sports Podcast Network, visit https://www.cbssports.com/podcasts/ You can listen to Fantasy Baseball Today Express on your smart speakers! Simply say "Alexa, play the latest episode of the Fantasy Baseball Today in 5 podcast" or "Hey Google, play the latest episode of the Fantasy Baseball Today in 5 podcast." To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices
Things just keep getting worse for the Diamondbacks this season. After tossing four scoreless innings in the team's series finale win over the Nationals, D-backs starter Corbin Burnes exited the game early with an apparent elbow injury. While we wait for the results of the MRI, we discuss what the Snakes did to deserve this, how Ryne Nelson's role has potentially changed, and if Torey Lovullo is to blame for the injury. We also have answers to your Mailbag Monday questions and welcome back the one and only Damon Fairall to the show!An ALLCITY Network ProductionSUBSCRIBE to our YouTube: https://bit.ly/phnx_youtubeALL THINGS PHNX: http://linktr.ee/phnxsportsMERCH https://store.allcitynetwork.com/collections/phnx-lockerALLCITY Network, Inc. aka PHNX and PHNX Sports is in no way affiliated with or endorsed by the City of PhoenixPHNX Events: Get your tickets to PHNX events and takeovers here: https://gophnx.com/events/ALLCITY — including us here at PHNX — is teaming up with Big Brothers Big Sisters of America for an exciting three-year partnership. To learn more, visit https://www.bbbs.org/allcity/APS: Find instant rebates, discounts and special offers on smart thermostats, energy-efficient appliances and more at https://marketplace.aps.com/default/heating-cooling/smart-thermostatsChicken N' Pickle: Family friendly fun awaits! Visit chickennpickle.com to plan your visit today!bet365: https://www.bet365.com/hub/en-us/app-hero-banner-1?utm_source=affiliate&utm_campaign=usapp&utm_medium=affiliate&affiliate=365_03485317 Use the code PHNX365 to sign up, deposit $10 and bet $5 to get $150 in bonus bets!Disclaimer: Must be 21+ and physically located in AZ. If you or someone you know has a gambling problem and wants help, call 1-800-NEXT-STEP, text NEXTSTEP to 53342 or visit https://problemgambling.az.gov/Branded Bills: Use code BBPHNX at https://www.brandedbills.com/ for 20% off your first order!Gametime: Download the Gametime app, create an account, and use code PHNX for $20 off your first purchase. Terms apply.Shady Rays: Head to https://shadyrays.com and use code: PHNX for 35% off polarized sunglasses. Try for yourself the shades rated 5 stars by over 300,000 people.Circle K: Join Inner Circle for free by downloading the Circle K app today! Head to https://www.circlek.com/store-locator to find Circle Ks near you!Monarch Money: Use Monarch Money to get control of your overall finances with 50% off your first year at https://www.monarchmoney.com/phnxCarol Royse Team: To buy/sell your home, call Carol Royse at 480-776-5231 or visit carolroyseteam.comAll Pro Shade Concepts: Call 623-204-1476 or visit https://allproshadeconcepts.com/ now to schedule your free estimate!When you shop through links in the description, we may earn affiliate commissions. Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing.#dbacks #diamondbacks #arizonadiamondbacks #mlb #zacgallen#corbincarroll #ketelmarte #mlbtheshow #mlbtraderumors #tradedeadline #traderumors #allstargame
Hosts Jim DeRogatis and Greg Kot pay tribute to the late singer-songwriter Jill Sobule. They revisit their 2009 conversation with Jill where they discuss her music and being a pioneer for crowdfunding art. They also review the new music from Shamir, Pelican and tUnE-yArDs.Join our Facebook Group: https://bit.ly/3sivr9TBecome a member on Patreon: https://bit.ly/3slWZvcSign up for our newsletter: https://bit.ly/3eEvRnGMake a donation via PayPal: https://bit.ly/3dmt9lUSend us a Voice Memo: Desktop: bit.ly/2RyD5Ah Mobile: sayhi.chat/soundops Featured Songs:Jill Sobule, "Supermodel," Jill Sobule, Lava, 1995The Beatles, "With A Little Help From My Friends," Sgt. Pepper's Lonely Hearts Club Band, Parlophone, 1967Tune-Yards, "Heartbreak," Better Dreaming, 4AD, 2025Tune-Yards, "Limelight," Better Dreaming, 4AD, 2025Tune-Yards, "See You There," Better Dreaming, 4AD, 2025Tune-Yards, "Never Look Back," Better Dreaming, 4AD, 2025Tune-Yards, "Sanctuary," Better Dreaming, 4AD, 2025Pelican, "Evergreen," Flickering Resonance, Run for Cover, 2025Pelican, "Flickering Stillness," Flickering Resonance, Run for Cover, 2025Pelican, "Pining For Ever," Flickering Resonance, Run for Cover, 2025Pelican, "Cascading Crescent," Flickering Resonance, Run for Cover, 2025Pelican, "Indelible," Flickering Resonance, Run for Cover, 2025Shamir, "Neverwannago," Ten, Kill Rock Stars, 2025Shamir, "Recording 291," Ten, Kill Rock Stars, 2025Shamir, "Pin," Ten, Kill Rock Stars, 2025Jill Sobule, "I Kissed a Girl," Jill Sobule, Lava, 1995Jill Sobule, "Palm Springs (Live on Sound Opinions)," California Years, MRI, 2009Jill Sobule, "San Francisco," California Years, MRI, 2009Katy Perry, "I Kissed a Girl," One of the Boys, Capitol, 2008Jill Sobule, "Nothing to Prove (Live on Sound Opinions)," California Years, MRI, 2009Jill Sobule, "Wendell Lee (Live on Sound Opinions)," California Years, MRI, 2009Diarrhea Planet, "Separations," I'm Rich Beyond Your Wildest Dreams, Infinite Cat, 2013See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode, we dive into the history of polymyalgia rheumatica, how it was discovered and its link to giant cell arteritis. Intro 0:01 In this episode 0:10 What is polymyalgia rheumatica (PMR)? 0:24 The history of PMR 02:12 PMR in the 1950s: A formally recognized disease 04:52 What was probably PMR in the 1880s 06:27 Naming PMR: Senile rheumatic gout 07:26 1957: The witch's shot and finally landing on polymyalgia rheumatica 08:30 Where is PMR coming from? 14:42 Injecting joins with saline 16:39 A biopsy study in 1964 19:54 Technetium bone scintigraphy in 1971 and bone scan history 23:01 First look at a PMR ultrasound in 1993 27:00 1997: First use of MRI on PMR patients in Italy 27:49 Going back to 1962: PMRs association with giant cell arteritis 30:40 A paper on muscular involvement in giant cell arteritis: 80-year-old ‘robust' partially blind seaman 32:15 First systematic approach: The link between PMR and giant cell arteritis 35:14 80 cases of PMR 38:13 Swedish autopsy studies 41:07 Introduction of advanced imaging in the 1990s 42:40 Summing up PMR through the decades 43:28 That is the end! 45:25 Thanks for listening 45:50 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bruk MI. Ann Rheum Dis. 1967;doi:10.1136/ard.26.2.103. Cantini F, et al. J Rheumatol. 2001;28(5):1049-55. De Miguel E, et al. Rheumatology (Oxford). 2024;doi:10.1093/rheumatology/kead189. Dixon AS, et al. Ann Rheum Dis. 1966;doi:10.1136/ard.25.3.203. Hamrin B, et al. Ann Rheum Dis. 1968;doi:10.1136/ard.27.5.397. Salvarani C, et al. Ann Intern Med. 1997;doi:10.7326/0003-4819-127-1-199707010-00005. Shah S, et al. Rheumatology (Oxford). 2025;doi:10.1093/rheumatology/keae569. Disclosures: Brown reports no relevant financial disclosures.
Broadcast from KSQD, Santa Cruz on 5-30-2024 and 5-29-2925: Cognitive errors in medicine dismissing unusual presentations as psychological A case of Pediatric Autoimmune Neuropsychiatric disorders Associated with Streptococcal Infections (PANDAS) Anti-NMDA receptor encephalitis causing psychiatric symptoms Failures of genetic research to identify causes Need for integrating neurology and psychiatry; Importance of testing for antibodies and using MRI scans Detailed explanation of immune tolerance, peripheral tolerance, and the phenomenon of molecular mimicry in diseases like multiple sclerosis and celiac disease Importance of addressing root causes rather than just symptoms Historical context and current advancements in treating autoimmune diseases like type 1 diabetes, lupus, and multiple sclerosis using reprogrammed immune cells and iron oxide nanoparticles Explanation of how the liver filters blood and helps establish immune tolerance by processing cellular debris and antigens Advances in engineering regulatory T cells to target specific disease sites and calm inflammatory responses Exploration of new diagnostic tools and the potential of AI in understanding complex psychiatric conditions Detection of colds and other diseases by analysis of voice frequency patterns
In this episode of A Couple of Rad Techs, Chaundria explores the rapid evolution of medical imaging and what it means for radiologic technologists on the front lines. From AI-driven image reconstruction to hybrid imaging modalities, the landscape is changing fast. But staying relevant doesn't always mean working with brand-new equipment. Chaundria discusses how technologists can build confidence and stay career-ready through ASRT's Directed Readings, webinars, and advocacy efforts. She also breaks down the common fear of falling behind and offers real-world strategies for keeping your edge, even in a facility that hasn't upgraded in years. Whether you're a CT, MRI, or X-ray tech—or just trying to pivot into something new—this episode will help you rethink what growth looks like in today's imaging environment.
In this AI-generated episode of Radiology AI Papers in a Capsule, we discuss a study that extends the NeuroHarmony AI model to address scanner variability in brain MRI for Alzheimer's disease assessment. Learn how incorporating cognitive status into harmonization may improve the reliability of quantitative imaging across diverse clinical settings. A Machine Learning Model to Harmonize Volumetric BrainMRI Data for Quantitative Neuroradiologic Assessment ofAlzheimer Disease. Archetti and Venkatraghavan et al. Radiology: Artificial Intelligence 2025; 7(1):e240030.
This week's topics include the worldwide burden of skin cancers, risk of a second stroke when a person is taking anticoagulants, patients supporting each other for weight loss maintenance, and imaging for dense breasts.Program notes:0:45 Dense breast tissue imaging1:40 MRI and contrast enhanced mammography superior2:40 Giving IV contrast with mammography2:53 Burden of skin cancer in older adults worldwide3:52 Greater disease burden in men4:53 More likely to have exam and biopsy5:48 Atrial fibrillation, recurrent stroke risk and anticoagulants6:50 One in six will recur7:50 Atrial appendage occulsion?8:20 Patient delivered weight loss management9:20 Five percent or greater initial weight loss10:20 Reduced the amount of weight regain11:22 Much less than a professional's care12:49 End
Join Elevated GP: www.theelevatedgp.com Free Class II Masterclass - Click Here to Join Follow @dental_digest_podcast Instagram Follow @dr.melissa_seibert on Instagram Dr. Drew McDonald is a board-certified orthodontic specialist renowned for his expertise in airway and temporomandibular joint (TMJ)-focused treatment planning, surgically facilitated orthodontic therapy (SFOT), and complex interdisciplinary care. He is based in St. Petersburg, Florida, where he leads McDonald Orthodontics, a practice dedicated to comprehensive, patient-centered orthodontic solutions.
In this JCO Article Insights episode, host Michael Hughes summarizes "Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma" by Kaiser et al, published February 18, 2025, followed by an interview with JCO Associate Editor Suzanne Lentzsch. Transcript Michael Hughes: Welcome to this episode of JCO Article Insights. This is Michael Hughes, JCO's editorial fellow. Today I have the privilege and pleasure of interviewing Dr. Suzanne Lentzsch on the “Co-Occurrence of Cytogenetic Abnormalities and High-Risk Disease in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma” by Dr. Kaiser and colleagues. At the time of this recording, our guest has disclosures that will be linked in the transcript. The urge to identify patients with aggressive disease, which is the first step in any effort to provide personalized medical care, is intuitive to physicians today. Multiple myeloma patients have experienced heterogeneous outcomes since we first started characterizing the disease. Some patients live for decades after treatment. Some, irrespective of treatment administered, exhibit rapidly relapsing disease. We term this ‘high-risk myeloma'. The Durie-Salmon Risk Stratification System, introduced in 1975, was the first formal effort to identify those patients with aggressive, high-risk myeloma. However, the introduction of novel approaches in therapeutic agents—autologous stem cell transplantation with melphalan conditioning, proteasome inhibitors like bortezomib, or immunomodulatory drugs like lenalidomide—rendered the Durie-Salmon system a less precise predictor of outcomes. The International Staging System in 2005, predicated upon the burden of disease as measured by beta-2 microglobulin and serum albumin, was the second attempt at identifying high-risk myeloma. It was eventually supplanted by the Revised International Staging System (RISS) in 2015, which incorporated novel clinical and cytogenetic markers and remains the primary way physicians think about the risk of progression or relapse in multiple myeloma. Much attention has been focused on the canonically high-risk cytogenetic abnormalities in myeloma, typically identified by fluorescence in situ hybridization: translocation t(4;14), translocation t(14;16), translocation t(14;20), and deletion of 17p. Much attention also has been focused on the fact that intermediate-risk disease, as defined by the RISS, has been shown to be a heterogeneous subgroup in terms of survival outcomes. The RISS underwent revision in 2022 to account for such heterogeneity and has become the R2-ISS, published here in the Journal of Clinical Oncology first in 2022. Translocations t(14;16) and t(14;20) were removed, and gain or amplification of 1q was added. Such revisions to core parts of a modern risk-stratification system reflect the fact that myeloma right now is in flux, both in treatment paradigms and risk-stratification systems. The field in recent years has undergone numerous remarkable changes, from the advent of anti-CD38 agents to the introduction of cellular and bispecific therapies, to the very technology we use to investigate genetic lesions. The major issue is that we're seeing numerous trials using different criteria for the definition of high-risk multiple myeloma. This is a burgeoning problem and speaks very much now to a critical need for an effort to consolidate all these criteria on at least cytogenetic lesions as we move into an era of response-adapted treatment strategies. The excellent article by Kaiser and colleagues, published in the February 2024 edition of the JCO, does just that in a far-ranging meta-analysis of data from 24 prospective therapeutic trials. All 24 trials were phase II or III randomized controlled trials for newly diagnosed and relapsed/refractory multiple myeloma. The paper takes a federated analysis approach: participants provided summaries and performed prespecified uniform analyses. The high-risk cytogenetic abnormalities examined were translocation t(4;14), gain or amplification of 1q, deletion of 17p, and translocation t(14;16), if included in the original trials. All of these were collected into zero, single, or double-hit categories, not unlike the system currently present in diffuse large B-cell lymphomas. The outcomes studied were progression-free survival and overall survival, with these analyses adhering to modified ITT principles. The authors also performed prespecified subgroup analyses in the following: transplant-eligible newly diagnosed myeloma, transplant non-ineligible newly diagnosed myeloma, and relapsed/refractory myeloma. They, in addition, described heterogeneity by the I2 statistic, which, if above 50%, denotes substantial heterogeneity by the Cochrane Review Handbook, and otherwise performed sensitivity analyses and assessed bias to confirm the robustness of their results. In terms of those results, looking at the data collected, there was an appropriate spread of anti-CD38-containing and non-containing trials. 7,724 patients were evaluable of a total 13,926 enrolled in those 24 trials: 4,106 from nine trials in transplant-eligible myeloma, 1,816 from seven trials in transplant non-ineligible myeloma, and 1,802 from eight trials in relapsed/refractory disease. ISS stage for all patients was relatively evenly spread: stage I, 34.5%; stage II, 37%; stage III, 24%. In terms of high-risk cytogenetic lesions, double-hit disease was present in 13.8% of patients, and single-hit disease was present in 37.4%. In terms of outcomes, Kaiser and colleagues found a consistent separation in survival outcomes when the cohort was stratified by the number of high-risk cytogenetic lesions present. For PFS, the hazard ratio was for double-hit 2.28, for single-hit 1.51, without significant heterogeneity. For overall survival, the hazard ratio was for double-hit disease 2.94, single-hit disease 1.69, without significant heterogeneity except in patients with double-hit disease at 56.5%. By clinical subgroups, hazard ratios remained pretty consistent with the overall cohort analysis. In transplant-eligible newly diagnosed myeloma, the hazard ratio for progression is 2.53, overall survival 4.17. For transplant non-ineligible, 1.97 progression, 2.31 mortality. Relapsed/refractory disease progression 2.05, overall mortality 2.21, without significant heterogeneity. Of trials which started recruitment since 2015, that is to say, since daratumumab was FDA approved and thus since an anti-CD38 agent was incorporated into these regimens, analysis revealed the same results, with double-hit myeloma still experiencing worse survival by far of the three categories analyzed. Risk of bias overall was low by advanced statistical analysis. In terms of subgroup analysis, double-hit results for transplant-eligible newly diagnosed myeloma may have been skewed by smaller study effects, where the upper bound of the estimated hazard ratio for mortality reached into the 15 to 20 range. In conclusion, from a massive amount of data comes a very elegant way to think about the role certain cytogenetic abnormalities play in multiple myeloma. A simple number of lesions - zero, one, or at least two - can risk-stratify. This is a powerful new prognostic biomarker candidate and, somewhat soberingly, also may confirm, or at least suggests, that anti-CD38 agents are unable to overcome the deleterious impact of certain biologic characteristics of myeloma. Where do we go from here? This certainly needs further a priori prospective validation. This did not include cellular therapies. The very scale at which this risk-stratification system operates, agnostic to specific genetic lesion, let alone point mutations, lends itself also to further exploration. And to discuss this piece further, we welcome the one and only Dr. Suzanne Lentzsch to the episode. Dr. Lentzsch serves as an associate editor for JCO and is a world-renowned leader at the bleeding edge of plasma cell dyscrasia research. Dr. Lentzsch, there are several new investigations which suggest that translocation t(4;14), for example, is itself a heterogeneous collection of patients. There are other studies which suggest that point mutations in oncogenes like TP53, which were not assessed in Kaiser et al., carry substantial detrimental impact. Is this classification system - no-hit, single-hit, double-hit - too broad a look at tumor genetics? And how do you think we will end up incorporating ever more detailed investigations into the genetics of multiple myeloma moving forward? Dr. Suzanne Lentzsch: Michael, first of all, excellent presentation of that very important trial. Great summary. And of course, it's a pleasure to be here with JCO and with you to discuss that manuscript. Let me go back a little bit to high-risk multiple myeloma. I think over the last years, we had a lot of information on what is high-risk multiple myeloma, and I just want to mention a couple of things, that we separate not only cytogenetically high-risk multiple myeloma, we also have functional high-risk multiple myeloma, with an early relapse after transplant, within 12 months, or two years after start of treatment for the non transplant patients, which is difficult to assess because you cannot decide whether this is a high-risk patient before you start treatment. You only know that in retrospective. Other forms of high-risk: extramedullary disease, circulating tumor cells/plasma cell dyscrasia, patients who never achieve MRD positivity, extramedullary multiple myeloma, or even age and frailty is a high risk for our patients. Then we have gene expression and gene sequencing. So there is so much information currently to really assess what is high-risk multiple myeloma, that is very difficult to find common ground and establish something for future clinical trials. So what Dr. Kaiser did was really to develop a very elegant system with information we should all have. He used four factors: translocation t(14;16), t(4;14), gain or amplification of 1q, and deletion of 17p. Of course, this is not the entire, I would say, information we have on high risk, but I think it's a good standard. It's a very elegant system to really classify a standard single-hit, double-hit, high-risk multiple myeloma, which can be used for all physicians who treat multiple myeloma, and especially, it might also work in resource-scarce settings. So, ultimately, I think that system is an easy-to-use baseline for our patients and provides the best information we can get, especially with a baseline, in order to compare clinical trials or to compare any data in the future. Michael Hughes: Thank you, Dr. Lentzsch. To the point that you made about this isn't the full story. There does, as you said, exist this persistent group of functional high-risk multiple myeloma where we see standard-risk cytogenetics, but these patients ultimately either exhibit primary refractory disease or very early relapse despite aggressive, standard aggressive treatment. How do you see risk-stratification systems incorporating other novel biomarkers for such patients? Is it truly all genetic? Or is next-generation sequencing, gene expression profiling, is that the answer? Or is there still a role for characterizing tumor burden? Dr. Suzanne Lentzsch: Excellent question, Michael, and I wish I would have the glass ball to answer that question. I see some problems with the current approach we have. First of all, to do the cytogenetics, you need good material. You only detect and identify what you have. If the bone marrow is of low quality, you have mainly peripheral blood in your bone marrow biopsy, you might not really fully have a representation of all cytogenetic changes in your bone marrow. So I think with a low-quality sample, that you might miss one or the other really cytogenetic high risk. So, having said this, I think circulating tumor cells, that might be something we will look into in the future, because circulating tumor cells are readily available, can be assessed without doing a bone marrow biopsy. And what is even more exciting, in addition to the circulating tumor cells or plasma cells, using them is next-generation sequencing. I think at the moment, we are more in a collection phase where we really try to correlate sequencing with our cytogenetics and especially to establish next-generation sequencing in all of our patients. But I think after that collection phase, maybe in the future, collecting peripheral blood and doing sequencing on peripheral blood samples might be the way to go. In addition, I don't want to forget the imaging. We started with a skeletal survey, and we know that you probably need to lose 30% of the bone before you see a lesion at all. So having imaging, such as diffusion-weighted imaging, whole-body MRI, is also, together with sequencing of the tumor cells, a step into the right direction. Michael Hughes: Thank you, Dr. Lentzsch. Bringing this back to the article at hand, how has Kaiser et al. changed the way we discuss myeloma with patients in the exam room? Dr. Suzanne Lentzsch: I think we have more data on hand. So far, we talked about standard risk and high risk, but I think right now, with a very simple system, we can go into the room and we can tell the patient, "Listen, you don't have any of those cytogenetic abnormalities. I think you have a standard risk. We might give you a simple maintenance treatment with Revlimid." But we might also go into the room and say, "I'm really concerned. You have so-called double-hit multiple myeloma. You have high-risk and at least two of those abnormal cytogenetics which we discussed, and I think you need a more intense maintenance treatment, for instance, double maintenance." I think we know that a high-risk multiple myeloma can be brought into a remission, but the problem that we have is to keep those patients into a remission. So, I think a more intense treatment, for instance, with a double maintenance, or with consolidation after transplant, and a longer and more intense treatment is justified in patients who have that truly high-risk multiple myeloma described here. Michael Hughes: Dr. Lentzsch, thank you so much for your time and your wisdom. Dr. Suzanne Lentzsch: My pleasure. Thank you for having me. Michael Hughes: Listeners, thank you for listening to JCO Article Insights. Please come back for more interviews and article summaries, and be sure to leave us a rating and review so others can find our show. For more podcasts and episodes from ASCO, please visit ASCO.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
In the second installment of this three-part series, Dr. Elizabeth Zollos discusses the use of magnetic resonance imaging (MRI) in multiple sclerosis diagnosis.
In this episode of Rehab Science, Dr. Tom Walters, DPT, breaks down cervical radiculopathy—a common condition involving compression or irritation of the nerve roots in the neck. He explores the relevant cervical spine anatomy, including how disc herniations or degenerative changes like bone spurs can narrow the neural foramina and impinge nerve roots, leading to symptoms that radiate from the neck into the arm and hand. Dr. Walters reviews hallmark symptoms such as radiating pain, numbness, tingling, and muscle weakness, and discusses how these typically follow a dermatomal distribution depending on the affected cervical level. Dr. Walters also explains the clinical examination process for diagnosing cervical radiculopathy, including provocative orthopedic tests and the role of imaging like MRI when necessary. He outlines both medical and physical therapy approaches to treatment—ranging from anti-inflammatory medications and injections to targeted rehab strategies like cervical traction, neural mobilization, postural correction, and strengthening exercises. The episode wraps up with practical advice for managing this condition through movement-based rehabilitation. YouTube Video with Exercises Nerve Mobilization Exercises Amazon Book Link
Welcome to Season 2 of the Orthobullets Podcast.Today's show is Podiums, where we feature expert speakers from live medical events. Today's episode will feature Dr. Hollis Potter and is titled "MRI of Shoulder and Elbow Baseball Injuries"Follow Orthobullets on Social Media:FacebookInstagram LinkedIn
The Bible's Faith Hall of Fame includes the name of a harlot. Pastor Ray Bentley says that's not the only surprise about Rahab. Do you realize Rahab is in the genealogy of Jesus Christ, the Messiah, the incarnate God, manifest in the flesh? So, wow. An MRI harlot becomes a believer. What does that tell you about our king and about his kingdom spreading?
Short N Sweet! This month's Clinical Corner Article covers a case study of a patient presenting with rotator cuff issues. After months of pain and many rounds of cortisone injections, she finally decided to visit a PT. Eight weeks of treatment went by with her pain not resolving, and her shoulder still "feeling stuck". This lead her PT to refer her on to getting an MRI- which eventually uncovered an aneurysmal bone cyst! This case is a great example to show patients they should not wait to be treated for their pain, and how the healthcare system can work together to find the answers to your issues to get you back to pain-free living!Read the article here: https://www.jospt.org/doi/10.2519/josptcases.2022.10897Did you know that you don't need a doctor's prescription to receive physical therapy? The laws of Direct Access allow you to receive physical therapy without a referral and still use your insurance benefits! Learn more on how Direct Access can help YOU! Our website: https://www.oxfordphysicaltherapy.com/
In today's episode, we welcome a very special guest, 18-year-old Australian phenom Cameron Myers. Dive into Cam's professional journey, his unique training under legendary coach Dick Telford, and his exciting 2025 race schedule. The crew also shares personal updates, including Olli's murder mystery, Morgan's MRI love affair, George's upcoming steeple season debut, and candid discussions on track and field's biggest topics like the Grand Slam Track series and its current impact on the sport.If you enjoyed this episode, please consider leaving us a 5 star review! It helps the pod a lot, and most importantly it helps Gus.Special Guest: https://www.instagram.com/camer0nmyers/Thumbnail Photo: https://www.instagram.com/jacob_gower_/Follow us here:Instagram: https://www.instagram.com/coffeeclub.pod/George Beamish: https://www.instagram.com/georgebeamish/Morgan McDonald: https://www.instagram.com/morganmcdonald__/Olli Hoare: https://www.instagram.com/ollihoare/Tom Wang: https://www.instagram.com/womtang/Coffee Club Merch: https://coffeeclubpod.comMorgan's discord: https://discord.gg/uaCSeHDpgsMorgan's YouTube: https://www.youtube.com/@MorganMcDonaldisaloserIntro Artwork by The Orange Runner: https://www.instagram.com/theorangerunner/Intro Music by Nick Harris: https://open.spotify.com/artist/3Zab8WxvAPsDlhlBTcbuPi0:00 Cameron Myers Prophecy1:25 Welcome to Coffee Club Podcast (Ep. 187)1:50 Jakob Ingebrigtsen Injury Update2:51 Track Fest Preview: LA & Sound Running3:48 Ollie's Training, Frustrations & Coffee Habits5:52 Happy Birthday, Rob!7:20 Ollie's Coffee & Burger Obsessions9:35 In-N-Out Expansion11:37 Car Hunting & Tariff Concerns15:47 Morgan's Injury & MRI Update18:18 First Water Jump Since Olympics20:00 Track Fest Race Previews & OAC Runners26:00 George's Steeplechase & Morgan Haircut Update31:00 Interview with Cameron Myers39:13 Cameron Myers' Training & Race Schedule47:45 Cameron Myers on Jingy Comparisons & NCAA Decision57:38 Ollie's Commonwealth Games Story1:01:40 Cam Myers' Wisdom1:04:37 Post-Interview Thoughts & Training Discussion1:08:18 Grand Slam Track Debate Continues1:16:03 Why Sprints are "Boring"1:22:20 Ideal Track Meet Format1:25:40 Outro & Call to Action
Send us a textWhen Final Destination: Bloodlines shattered box office expectations with a $100 million worldwide haul, it proved that even after 14 years, Death's design still captivates audiences hungry for creative kills and nail-biting tension. But how does this sixth installment stack up against its predecessors?Join hosts Alex, Max, and Erica as they journey through the entire Final Destination franchise, ranking all six films and dissecting what makes these movies uniquely addictive despite their often schlocky nature. From the high-concept original that launched the series in 2000 to the roller coaster thrills of Final Destination 3 and beyond, we explore how each film contributes to the franchise's legacy.The conversation dives deep into the franchise's most memorable moments – that infamous highway log truck scene from the second film, the tanning bed sequence that made an entire generation claustrophobic, and the MRI machine magnetic catastrophe in the latest installment. We examine how these films function as perfect time capsules of their respective eras, particularly Final Destination 3's pitch-perfect capture of mid-2000s teen culture complete with low-rise jeans, flip phones, and digital cameras.Beyond the kills, we appreciate the connective tissue binding these films together – Tony Todd's ominous presence, recurring motifs like Heist Pale Ale appearances, and the number 180 popping up throughout. We also explore the franchise's possible origins in a specific Twilight Zone episode and debate whether Bloodlines' hereditary curse concept successfully evolves the series.Whether you're a long-time fan who's seen every installment or someone curious about this enduring horror phenomenon, our ranking provides the perfect roadmap through Death's design. Listen now, and remember – you can't cheat death, but you can enjoy watching others try.Support the show
It's Prostate Week in Podcastistan: what happens when an MRI scan for prostatitis includes the injection of rare earth metals—should you, or shouldn't you? Gadolinium crosses the blood-brain barrier if the barrier is not fully intact—does that affect your decision? Then: a letter from an MD-PhD student at Harvard prompts musings on the federal funding of science, what science is for, how complicit universities and many scientists have been for years, and what to do. Also: uterine transplants for “trans women.”*****Our sponsors:Timeline: Accelerate the clearing of damaged mitochondria to improve strength and endurance: Go to http://www.timeline.com/darkhorse and use code darkhorse for 10% off your first order.Caraway: Non-toxic & beautiful cookware. Save $150 on a cookware set over buying individual pieces, and get 10% off your order at http://Carawayhome.com/DarkHorse10.ARMRA Colostrum is an ancient bioactive whole food that can strengthen your immune system. Go to http://www.tryarmra.com/DARKHORSE to get 15% off your first order.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:Gadolinium Contrast Dye: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-warns-gadolinium-based-contrast-agents-gbcas-are-retained-bodyLetter from Harvard: https://naturalselections.substack.com/p/letter-from-harvard/commentsHigher Education Research & Development Survey: https://ncses.nsf.gov/surveys/higher-education-research-development/2023#dataJones et al 2018. Uterine transplantation in transgender women. Bjog 126(2): 152-156: https://pmc.ncbi.nlm.nih.gov/articles/PMC6492192/pdf/BJO-126-152.pdfSupport the show
The Nats won their 4th straight on Tuesday night as they topped the visiting Braves 5-3. Al & Mark have a lot to get to as Dylan Crews homered in the victory, but was removed mid-game because of a back issue, and that means Robert Hassell III is getting called up from AAA-Rochester. Hassell is one of the pieces from the 2022 Juan Soto trade with the San Diego Padres.(05:50) Jacob Young did not play for a second straight game due to crashing his shoulder into the Camden Yards' wall on Saturday. It is unclear if Young or Crews will be headed to the IL, and that likely will be decided after Crews' MRI on Wednesday morning.(10:00) Hassell's OPS is at .742 this season with four homers. He had a pair of doubles on Tuesday night in Syracuse prior to getting informed that he is headed to Washington.(14:30) The Nats offense continued their recent string of hot starts by scoring three runs right away against Atlanta's Spencer Strider. They totaled eight hits in the win, but also had multiple terrible base running mistakes.(18:10) Mitchell Parker's outing was marred by a bad top of the 2nd where he gave up all three of his runs. It was the 5th consecutive Parker start that was not classified as "good".(20:15) The bullpen teamed up for nearly four scoreless innings. Kyle Finnegan punctuated the effort with a clean 1-2-3 inning for his 15th save of the year, which leads all of MLB.(26:10) Per the Washington Post, the team's Chief Revenue Officer and the Chief Marketing Officer left their positions earlier this month. What does that mean in the bigger picture or isolated personnel moves?
Today, I'm joined by Dr. Michael Doney, Executive Medical Director of Biograph. A preventative health and diagnostics clinic, Biograph combines comprehensive testing and personalized lifestyle interventions for a complete concierge medical experience. In this episode, we explore its approach to designing a next-gen patient journey. We also cover: Making data actionable Balancing scale with clinical rigor How Biograph differs from primary care Subscribe to the podcast → insider.fitt.co/podcast Subscribe to our newsletter → insider.fitt.co/subscribe Follow us on LinkedIn → linkedin.com/company/fittinsider Biograph Website: https://www.biograph.health/ - The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart workout solutions for fitness and health facilities. Fitt Talent: https://talent.fitt.co/ Consulting: https://consulting.fitt.co/ Investments: https://capital.fitt.co/ Chapters: (00:00) Introduction (02:00) Michael's background and transition to preventative health (04:05) How Biograph emerged from stealth mode (06:05) The comprehensive patient journey experience (08:45) Turning data into actionable health outcomes (13:05) The evidence-based approach to health span (17:20) Why more data doesn't always mean better health (19:40) Addressing concerns about accessibility in preventative health (21:20) Biograph's growth roadmap and digital platforms (23:15) Why physical locations remain essential (26:30) The clinical rigor behind whole body MRI programs (31:35) Supporting rather than disrupting primary care (35:45) Conclusion
Understanding Unicornuate Uterus: What It Is, Prevalence, Risks, and a Positive Outlook A unicornuate uterus is a rare congenital condition where the uterus develops with only one half, or "horn," instead of the typical two-horned shape of a normal uterus. This happens during fetal development when one of the Müllerian ducts, which form the uterus, fails to develop fully. As a result, the uterus is smaller, has only one functioning fallopian tube, and may or may not have a rudimentary horn (a small, underdeveloped second horn). This condition falls under the category of Müllerian duct anomalies, which affect the female reproductive tract. For those diagnosed, understanding the condition, its implications, and the potential for a healthy pregnancy can provide reassurance and hope. What Is a Unicornuate Uterus? The uterus typically forms as a pear-shaped organ with two symmetrical halves that fuse during fetal development. In a unicornuate uterus, only one half develops fully, creating a smaller-than-average uterine cavity. This anomaly can occur with or without a rudimentary horn, which may or may not be connected to the main uterine cavity. If a rudimentary horn is present, it might cause complications like pain if it accumulates menstrual blood, as it often lacks a connection to the cervix or vagina. The condition is often diagnosed during routine imaging, such as an ultrasound, MRI, or hysterosalpingogram (HSG), typically when a woman seeks medical advice for fertility issues, pelvic pain, or irregular menstruation. In some cases, it's discovered incidentally during pregnancy or unrelated medical evaluations. How Prevalent Is It? Unicornuate uterus is one of the rarest Müllerian duct anomalies, occurring in approximately 0.1% to 0.4% of women in the general population. Among women with Müllerian anomalies, it accounts for about 2% to 13% of cases. The condition is congenital, meaning it's present at birth, but it often goes undiagnosed until adulthood because many women experience no symptoms. Its rarity can make it feel isolating for those diagnosed, but awareness and medical advancements have made it easier to manage and understand. Risks Associated with Unicornuate Uterus While many women with a unicornuate uterus lead healthy lives, the condition can pose challenges, particularly related to fertility and pregnancy. The smaller uterine cavity and reduced endometrial surface area can increase the risk of certain complications, though these are not inevitable. Below are some potential risks: Fertility Challenges: The smaller uterus and single fallopian tube may slightly reduce the chances of conception, especially if the rudimentary horn or other structural issues interfere with ovulation or implantation. However, many women with a unicornuate uterus conceive naturally without intervention. Miscarriage: The limited space in the uterine cavity can increase the risk of miscarriage, particularly in the first trimester. Studies suggest miscarriage rates may be higher (around 20-30%) compared to women with a typical uterus, though exact figures vary. Preterm Birth: The smaller uterus may not accommodate a growing fetus as easily, potentially leading to preterm labor or delivery before 37 weeks. Research indicates preterm birth rates in women with a unicornuate uterus range from 10-20%. Fetal Growth Restriction: The restricted uterine space can sometimes limit fetal growth, leading to low birth weight or intrauterine growth restriction (IUGR). Malpresentation: Babies in a unicornuate uterus may be more likely to position themselves in a breech or transverse position due to the confined space, which could complicate delivery. Cesarean Section: While not mandatory, a cesarean may be recommended in cases of malpresentation, preterm labor, or other complications. However, this is not a universal requirement. Other Complications: Women with a unicornuate uterus may have a higher risk of endometriosis or painful periods, especially if a non-communicating rudimentary horn is present. Kidney abnormalities are also associated with Müllerian anomalies, as the kidneys and reproductive tract develop simultaneously in the fetus. Despite these risks, it's critical to note that not every woman with a unicornuate uterus will experience these complications. With proper medical care, many achieve successful pregnancies and deliveries. A Positive Outlook: Normal Vaginal Delivery Is Probable The diagnosis of a unicornuate uterus can feel daunting, but it's important to emphasize that a healthy, full-term pregnancy and a normal vaginal delivery are entirely possible. Advances in obstetrics and prenatal care have significantly improved outcomes for women with this condition. Here's why you can remain optimistic: Personalized Care: Working with an experienced obstetrician or maternal-fetal medicine specialist ensures close monitoring throughout pregnancy. Regular ultrasounds can track fetal growth, position, and amniotic fluid levels, allowing for timely interventions if needed. Not Doomed to Cesarean: While some women may need a cesarean due to specific complications, many with a unicornuate uterus deliver vaginally without issue. The decision depends on factors like fetal position, labor progression, and overall health, not the uterine anomaly alone. Full-Term Pregnancies Are Achievable: With careful monitoring, many women carry their pregnancies to term (37-40 weeks). Preterm birth is a risk, but it's not a certainty, and modern neonatal care can support babies born slightly early if needed. Healthy Babies: Countless women with a unicornuate uterus give birth to healthy, thriving babies. The condition does not inherently affect the baby's development or genetic health. Support and Advocacy: Connecting with others who have similar experiences, whether through online communities or support groups, can provide emotional strength and practical advice. Knowing you're not alone can make all the difference. A unicornuate uterus is a rare but manageable condition that requires awareness and, in some cases, specialized care. While there are risks to consider, they are not insurmountable, and many women with this anomaly experience successful pregnancies and vaginal deliveries without complications. With the right support, you can embrace your unique journey, knowing that a unicornuate uterus does not mean you're destined for preterm birth, cesarean delivery, or pregnancy complications. Instead, it's a testament to your resilience and the incredible capabilities of modern medicine to support you every step of the way. Connect With Us: YouTube: Dive deeper into pregnancy tips and stories atyoutube.com/maternalresources . Instagram: Follow us for daily inspiration and updates at @maternalresources . Facebook: Join our community at facebook.com/IntegrativeOB Tiktok: NatureBack Doc on TikTok Grab Our Book! Check out The NatureBack Method for Birth—your guide to a empowered pregnancy and delivery. Shop now at naturebackbook.myshopify.com .
Dave and Chuck the Freak talk about why a lady shot a guy in the balls, a fight with sex toys, what happened when a gun got too close to an MRI machine, the judge who sentenced a woman to work at a fast food restaurant, what makes the perfect ass, a woman who tried out sex toys right in the aisle of a store, when sex almost lead to death for you, a listener’s dad’s nipple rings, having sex at your grandparents’ house, a deadly accident involving a driverless car, safe drinking recommendations in Canada, a Mexican elf spotted in a tree, why a woman tried to run over her boyfriend, a family who realized the dog they had raised for a couple of years was actually a bear and more!
Shirley Manson is a singer and songwriter, most notably from the band Garbage, whose new record, Let All That We Imagine Be the Light, is out May 30th. We chat with Shirley from her home in Los Angeles about Diddy updates, DJ Akademiks, Esq., Chris is flying out of Newark tomorrow, walking in Los Angeles without a dog, octopuses are sentient beings, what she listens to in the MRI machine, how Chris cleans his bathroom, her shower schedule, sloppy seconds, when she gets nervous, streaming revenue, she says the phrase "player, please", the best ways for a band to break up, touring with Noel Gallagher, opening for My Chemical Romance, and the last time she did ecstacy. instagram.com/garbage twitter.com/donetodeath twitter.com/themjeans howlonggone.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Top Eight Most Shocking Claims in Cassie's Testimony Against Diddy What happens when the veil drops on one of hip-hop's most powerful figures? In this episode, we dive deep into Cassie Ventura's harrowing courtroom testimony against Sean “Diddy” Combs — a testimony so graphic, so disturbing, that at times the courtroom reportedly fell into total silence. Cassie, the former pop star and longtime partner of Diddy, outlined a pattern of abuse that prosecutors allege amounts to sex trafficking, coercive control, and sexual assault. In her raw and emotional testimony, she described what she called a “machine of control” — fueled by fear, drugs, humiliation, and surveillance. In this episode, we break down the 8 most disturbing allegations from her testimony, including: The 2016 Beverly Hills hotel assault — caught on surveillance footage and played in court. The coerced and drug-fueled “freak-offs” — with Cassie allegedly forced to perform while being filmed. The urination and degradation acts she endured — which she says pushed her into psychological dissociation. A shocking moment where Diddy allegedly obtained her private MRI results, monitoring even her attempts to seek medical help. The explosive claim that Diddy threatened rapper Kid Cudi — and then Cudi's car exploded. And finally, the most heartbreaking revelation: the 2018 rape allegation that marked her final escape. This is not tabloid gossip. These are federal allegations, with hard evidence backing parts of Ventura's account — including video, corroborating witnesses, and detailed timelines. If you've been following the Diddy trial, this is the episode you need to hear. No fluff. Just the most chilling, courtroom-verified claims from one of the most high-profile abuse cases in music industry history. Subscribe now for full coverage, expert analysis, and survivor-centered storytelling. #DiddyTrial #CassieTestimony #SexTrafficking #TrueCrime #HipHopScandal #CourtroomDrama #CassieVentura #SurvivorVoices #DiddyAllegations #CelebrityTrial Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/@hiddenkillerspod Instagram https://www.instagram.com/hiddenkillerspod/ Facebook https://www.facebook.com/hiddenkillerspod/ Tik-Tok https://www.tiktok.com/@hiddenkillerspod X Twitter https://x.com/tonybpod Listen Ad-Free On Apple Podcasts Here: https://podcasts.apple.com/us/podcast/true-crime-today-premium-plus-ad-free-advance-episode/id1705422872
On today's show, Pat, AJ Hawk, and the boys recap WWE Backlash, & the NBA & NHL playoff action from this weekend including the Pacers blowing out the Cavaliers in Game 4, the Dallas Stars taking the lead over the Winnipeg Jets, and of course the fall out from Pat's match against Gunther. In the first hour, we are joined by ESPN's Senior NBA Insider Shams Charania for an update on Giannis Antetokounmpo's openness to finding a new home in the league, Cavs' Guard Donovan Mitchell's MRI on his re-aggravated ankle injury, what to look for in the NBA Draft Lottery tonight, and more. Also in the first hour, ESPN's NHL play-by-play announcer Steve Levy stops by to chat about the main storylines from the Stanley Cup playoffs thus far, including Mikko Rantanen's outrageous production, what the Maple Leafs need to do against the Florida Panthers, and more. In the second hour, NFL Network's Senior Insider & friend of the progrum Ian Rapoport stops by to talk about the announcement of opening night between the Super Bowl Champion Philadelphia Eagles & the Dallas Cowboys, what to expect from schedule releases this week, an update on the Trey Hendrickson, Cincinnati Bengals contract stalemate, Derek Carr's retirement, the attention around Cleveland Browns' OTAs, and more. To wrap things up, we debuted a new iteration of Things That Are Happening In the Sports World. Make sure to subscribe to youtube.com/thepatmcafeeshow or watch on ESPN (12-2 EDT), ESPN's YouTube (12-3 EDT), or ESPN+. We appreciate the hell out of all of you. See you tomorrow. Cheers. Learn more about your ad choices. Visit podcastchoices.com/adchoices