Podcasts about Perlmutter

What if Alzheimer's doesn't begin when you start forgetting names or struggling with memory but decades earlier, when subtle changes are happening in your metabolism, inflammation, and brain?   With Alzheimer's in my own family, this conversation with Dr. David Perlmutter felt especially personal. Dr. Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and one of the leading voices challenging how we think about brain health and cognitive decline. His new book, Brain Defenders, explores emerging research around microglia — the immune cells of the brain — and why they may hold an important key to protecting our brains as we age.   We dive into why Dr. Perlmutter believes we need to start thinking about Alzheimer's prevention in our 30s and 40s, the surprising connection between metabolic health and the brain, and how our everyday choices may influence whether our brain's immune cells protect us or work against us. We also get into the role of ultra-processed foods, blood sugar and insulin, the gut microbiome, environmental toxins, sleep, inflammation, mitochondria, vitamin D, and some of the biomarkers Dr. Perlmutter believes are worth knowing. And for women, we explore what happens to the brain during menopause, the latest conversation around estrogen and hormone replacement therapy, and why women face a greater risk of Alzheimer's.   Dr. Perlmutter also shares fascinating new research that could change how we think about Alzheimer's, Parkinson's, MS, traumatic brain injury, and other neurological conditions — including why the future of brain health may look very different from the traditional “wait for symptoms, then treat” approach. This episode left me feeling incredibly hopeful about how much influence we may actually have over the future of our brains. If you've ever worried about your memory, your family history, or simply want to stay sharp and resilient as you age, this is a conversation you don't want to miss. Key Moments You'll Love ✨ :

Women are far more likely than men to develop Alzheimer's disease, and Dr. David Perlmutter believes one of the most important pieces of that story is metabolic health.In this episode of Live Like a Girl, Dr. Perlmutter joins Dr. Mindy to explain what happens when the brain's immune cells shift from protective to destructive, why menopause may increase vulnerability, and how blood sugar, insulin resistance, visceral fat, inflammation, mitochondrial health, and lifestyle all influence brain aging.They also discuss HRT, GLP-1 medications, ketones, fasting, fiber, exercise, BNDF, sleep, and what women can begin doing in their 30s, 40s, and 50s to support long-term cognitive health.In This Episode, You'll LearnWhy women face a higher risk of Alzheimer'sHow menopause may affect brain metabolismWhy belly fat and insulin resistance matter for brain healthThe blood markers Dr. Perlmutter watches most closelyWhat emerging research says about GLP-1 drugs and the brainThe lifestyle habits Dr. Perlmutter prioritizes for preventionResources MentionedBrain DefendersTanzi StudyCochrane ReviewMore on Dr. David Perlmutterhttps://drperlmutter.com/http://braindefenders.com/https://www.instagram.com/davidperlmutter/https://www.youtube.com/user/DavidPerlmutterMDhttps://x.com/davidperlmutterlinkedin.com/in/david-perlmutter-mdFor more resources related to today's episode, visit the podcast episode page: https://www.drmindypelz.com/ep363/Connect with Dr. Mindy:Join Reset AcademyWatch the episodes on YouTubeFollow Dr. Mindy on InstagramSubscribe to Dr. Mindy's newsletterDisclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.

Big Pharma bet billions on one theory: clear the amyloid, cure Alzheimer's.A new Cochrane review of 20,000+ patients just proved them wrong — these drugs don't work, and they may be putting your brain at risk. So what's really driving this epidemic?My guest today, six-time New York Times bestselling author and board-certified neurologist Dr. David Perlmutter, says the answer lies in a set of cells most people have never even heard of — and he lays it all out in his new book, Brain Defenders.The good news is, you already have more control over them than any drug could ever give you.We're talking about microglia, the brain's immune cells, and why the choices you make today may matter more than anything a prescription pad can offer.For full show notes and transcript: https://drgundry.com/david-perlmutter-alzheimersOn this episode, you'll learn: All about the new study that found leading Alzheimer's drugs deliver almost no benefit (02:09)Why the so-called enemy in your brain is not what we thought at all (07:34)What microglia are, and why these overlooked immune cells may be the real gatekeepers of your brain's health (05:15)How everyday metabolic issues like blood sugar and insulin resistance can affect your brain (09:30)Why one in nine Americans over 65 is already living with dementia (and most don't know it) (14:08)The surprising connection between Parkinson's, depression, and even autism spectrum conditions (15:11)How THIS lifestyle program helped 70% of Alzheimer's patients stabilize or even improve their cognitive function — no drugs required (17:09)The one mindset shift Dr. Perlmutter says has to happen before any diet or exercise plan will actually work for your brain (22:17)Why getting quality sleep does more for your brain than you think (27:49)The simple blood test you should request NOW to gauge your Alzheimer's risk (33:25)Why women make up two-thirds of Alzheimer's patients (35:29)The critical window for starting hormone replacement therapy (40:08)The truth about antibacterial mouthwash, and why it might be quietly working against your brain health (58:14)A 25-year-old flossing study that predicted exactly what today's top neurology journals are just now confirming (01:00:05)Dr. Perlmutter's honest answer to whether you should take the newer Alzheimer's drugs your doctor may be recommending (01:05:31)More about Dr. David Perlmutter:Dr. David Perlmutter's websiteDr. David Perlmutter's InstagramNew book: Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life by Dr. David PerlmutterResearch:Cochrane ReviewTanzi StudyThank you to our sponsors! Check them out: Transform your sleep experience with Cozy Earth bedding. Go to cozyearth.com/gundry for 20% off. Go to thrivemarket.com/GUNDRYPODCAST for 30% off your first order, plus a FREE $60 gift.Go to Quince.com/gundry to upgrade your wardrobe and get free shipping on your orderGet a quote today at Progressive.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Dr. Jockers sits down with neurologist and bestselling author Dr. David Perlmutter to explore microglia, the brain's immune cells, and the role they may play in protecting the brain from cognitive decline. You'll learn what can shift these cells from a supportive state toward one that promotes neuroinflammation.   Discover why your metabolic health and brain health are deeply connected. Dr. Perlmutter explains how blood sugar, insulin resistance, gut health, and chronic inflammation can influence microglial function and why addressing these factors may be important long before memory problems appear.   You'll also hear practical ways to support your brain through exercise, nutrition, sleep, metabolic flexibility, and other daily habits. Dr. Perlmutter shares why protecting your brain isn't just about what happens later in life—and how the choices you make today can help shape your cognitive future.   In This Episode:  00:00 Amyloid Myth Busted 00:15 Show Intro and Guest 04:18 Book Inspiration Microglia 06:02 Symptom Care vs Root Cause 09:51 Microglia M1 vs M2 11:15 Gut Brain Inflammation Link 15:01 Metabolism Mirrors Microglia 17:57 Infections Vaccines and Triggers 19:31 CTE Diabetes and Feedforward 25:20 New Tools and Beta Amyloid Drugs 30:37 Cochrane Verdict Drugs Fail 33:28 Lifestyle Trial Reverses Decline 38:23 Microglia Lifestyle Levers 39:07 Exercise Myokines Brain Boost 42:20 Alzheimers Risk Epigenetics 45:12 Imaging Microglia TSPO 46:24 Fasting Ketones Brain Fuel 49:45 MCT Oil Memory Care 51:16 POINTER Lifestyle Trial 55:57 Fiber Polyphenols Foods 58:34 Supplements DHA Vitamin D 01:02:23 Key Labs Glucose Tau 01:06:19 Prevention Mission Wrap 01:07:43 Final Thanks Outro   Enjoy a clean, protein-packed snack with PaleoValley's Grass-Fed Beef Sticks. Made without sugar, additives, or preservatives, they're packed with healthy fats and grass-fed nutrients to help curb cravings, support steady energy, and keep you satisfied on the go. Save 15% with code DRJOCKERS at paleovalley.com/drjockers.   Give your hair and skin routine an upgrade with iRestore's advanced red light therapy devices. The iRestore Elite combines 300 lasers and 200 LEDs to support thicker, healthier-looking hair, while the cordless Illumina Face Mask uses triple-wavelength light therapy to target fine lines, breakouts, and dullness. Take advantage of iRestore's Labor Day savings and huge discounts at iRestore.com and use promo code DRJOCKERS to save. Stop guessing about your health and start understanding what's happening inside your body with Superpower Health. One simple blood draw measures 100+ biomarkers covering your heart, liver, thyroid, hormones, metabolism, vitamins, minerals, and environmental toxins, plus you'll get ongoing tracking and access to a clinician team. Head to Superpower.com and use promo code JOCKERS to get $20 off your membership for a limited time.    Support your joints, hair, nails, skin, and recovery with BUBS Naturals Collagen Peptides, a tasteless, odorless formula that mixes easily into coffee, smoothies, or juice. It has zero sugar, sweeteners, or fillers and is third-party tested, NSF Certified for Sport, Whole30 Approved, and sustainably sourced from grass-fed, pasture-raised cattle. Head to BUBSNaturals.com and use promo code DRJOCKERS to get 20% off for a limited time. "Exercise isn't just changing your body. It's changing the environment inside your brain."   Subscribe to the podcast on: Apple Podcast Stitcher Spotify PodBean  TuneIn Radio   Resources:  Enjoy 15% off grass-fed beef sticks with code DRJOCKERS at paleovalley.com/drjockers. Go to iRestore.com and use promo code DRJOCKERS Visit Superpower.com and use promo code JOCKERS to get $20 off Visit BUBSNaturals.com and use promo code DRJOCKERS to get 20% off     Connect with Dr. David Perlmutter: Book - https://a.co/d/06cRZKlT Website - https://drperlmutter.com/   Connect with Dr. Jockers: Instagram – https://www.instagram.com/drjockers/ Facebook – https:/www.facebook.com/DrDavidJockers YouTube – https://www.youtube.com/user/djockers Website – https://drjockers.com/   If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/

For so many people, the thought of memory loss or cognitive decline feels frightening. But today's guest shares an empowering message: there is so much we can do through our daily choices to support brain health and reduce risk. I'm joined by Dr. David Perlmutter, board-certified neurologist, leading brain health expert, and bestselling author of Brain Defenders, to discuss what we can do today to protect our brains as we age.  We explore the important shift in how we understand brain health, looking at the bigger picture of immunometabolism, metabolic health, inflammation, and the environment that influences the brain long before symptoms appear. Dr. Perlmutter explains why habits that support the entire body, including blood sugar balance and reduced inflammation, can also support cognitive health.  He also shares exciting areas of research and reminds us that even small changes can create meaningful improvements over time. Just like we can take steps to support our bones, we can also support our brains through the choices we make every day.   "Your brain's destiny is in your hands. It's based upon the choices that you are going to make every single day. A cure for dementia is not going to be given to you in the form of a medication." ~ Dr. David Perlmutter   In this episode: - [03:22] - The new science of brain health and immunometabolism - [11:19] - Metabolic health and its impact on cognitive decline - [17:26] - Blood sugar, insulin resistance, and brain health - [28:35] - How to protect your brain as you age - [31:37] - Lab tests for proactive brain health - [39:15] - Environmental toxins, plastics, and brain health - [45:26] - Emerging therapies and the future of brain protection - [52:08] - Resources from Dr. Perlmutter   Resources - Osteoporosis Exercises to Strengthen Your Bones and Prevent Fractures - https://tinyurl.com/mystrongbonesexercises - Dr. Perlmutter's new book, Brain Defenders - https://drperlmutter.com/books/brain-defenders/ - Dr. Perlmutter's website - https://drperlmutter.com/   More about Margie - Website - https://margiebissinger.com/  - Facebook - https://www.facebook.com/p/Margie-Bissinger-MS-PT-CHC-100063542905332/  - Instagram - https://www.instagram.com/margiebissinger/?hl=en    DISCLAIMER – The information presented on this podcast should not be construed as medical advice. It is not intended to replace consultation with your physician or healthcare provider. The ideas shared on this podcast are the expressed opinions of the guests and do not always reflect those of Margie Bissinger and Happy Bones, Happy Life Podcast. *In compliance with the FTC guidelines, please assume the following about links on this site: Some of the links going to products are affiliate links of which I receive a small commission from sales of certain items, but the price is the same for you (sometimes, I even get to share a unique discount with you). If I post an affiliate link to a product, it is something that I personally use, support, and would recommend. I personally vet each and every product. My first priority is providing valuable information and resources to help you create positive changes in your health and bring more happiness into your life. I will only ever link to products or resources (affiliate or otherwise) that fit within this purpose.

“We can choose our brain's destiny,” says David Perlmutter, MD. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. He is on the Board of Directors of the American College of Nutrition and the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, has been published in 32 languages and sold over a million copies. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His new book, Brain Defenders, focuses on the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience, and is now available for pre-order. 00:00 - Treating the symptoms, not the cause  02:37 - Microglial cells & their evil twin state  05:44 - How metabolism affects the brain  08:00 - Gut bacteria, inflammation, & brain degeneration  11:38 - Why lifestyle beats the APOE4 gene  16:25 - Perlmutter's daily routine 23:55 - Loneliness & oxytocin  26:21 - The effects of long COVID on the brain 32:18 - Glyphosate & other environmental factors  39:20 - Reprogramming microglia & mitochondrial transplants  41:35 - Own your brain's destiny Referenced in the episode:  For more about Perlmutter, visit his website: https://drperlmutter.com/  Alzheimers & UPFs study: https://doi.org/10.1016/j.tjpad.2024.100042  POINTER study - https://jamanetwork.com/journals/jama/fullarticle/2837046  20-week Alzheimer's study:  https://link.springer.com/article/10.1186/s13195-024-01482-z  Golf course & Parkinson's study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. David Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, and brain health. A Fellow of the American College of Nutrition, he serves on its Board of Directors and on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the #1 bestseller Grain Brain, have been published in 32 languages and sold over a million copies. Dr. Perlmutter lectures globally at leading institutions and has been featured on major media outlets including 20/20, CNN, The Today Show, and Oprah. His contributions have earned him numerous national and international awards for clinical innovation and leadership. Today on the show, we discuss why Alzheimer's may be driven more by lifestyle than genetics, how insulin resistance and blood sugar can quietly damage the brain, the foods and eating habits that may protect cognitive health, why sleep, exercise, and social connection are critical for preventing decline, what caffeine, nicotine, marijuana, and alcohol actually do to the brain, and the simple changes you can start making today to protect your memory for decades to come. Thank you to today's sponsor: Momentous Try Momentous Signature Spec Creatine: https://www.livemomentous.com Use code ADVERSITY for up to 35% off your entire first order Learn more about your ad choices. Visit megaphone.fm/adchoices

  In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes renowned neurologist and bestselling author Dr. David Perlmutter to explore the emerging science behind brain health, neuroinflammation, and cognitive resilience. Drawing from his groundbreaking new book, Brain Defenders, Dr. Perlmutter explains how microglia—the brain's immune cells—play a central role in protecting or damaging the brain depending on our metabolism, lifestyle, and environment. Together they discuss why Alzheimer's and Parkinson's disease begin decades before symptoms appear, why inflammation and insulin resistance are major drivers of neurodegeneration, and what we can do today to protect lifelong brain health. Whether you're concerned about memory loss, dementia prevention, or optimizing cognitive performance, this episode offers science-backed strategies to build a healthier, more resilient brain.

In this episode, we sit down with neurologist Dr. David Perlmutter to explore the fascinating science behind optimal brain health. We dive deep into topics from microglial cells and immunometabolism to the importance of addressing root causes like lifestyle and diet for preventing neurodegenerative diseases.Dr. David Perlmutter shares his journey into integrative neurology, emphasizing how metabolic health, inflammation, and stress impact brain function. The conversation covers practical insights on how dietary choices, exercise, sleep, and stress management can maintain cognitive vitality and longevity. Groundbreaking concepts like biological aging, mitochondrial health, and the latest research on treatments and prevention round out an empowering and thought-provoking discussion.Ready to take control of your brain's future? Listen in, share this episode with three friends, and start applying these empowering insights to upgrade your health. Don't forget to check out Dr. Perlmutter's new book, Brain Defenders, for deeper guidance.  Dr. Navaz HabibEmail: podcast@healthupgraded.comFacebook: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabibJP ErricoInstagram: https://www.instagram.com/thevnsguy/LinkedIn: https://www.linkedin.com/in/jp-errico-097629aaDr. David PerlmutterWebsite: https://drperlmutter.com/Books: https://drperlmutter.com/books/

In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life. The post RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter appeared first on Chris Kresser.

Alzheimer's disease has grown to become the most common form of dementia, and as of now, there is no cure for this devastating neurodegenerative disease. But new science shows that your brain's immune cells play an essential role in how your brain ages. Today, you're going to learn this latest science and how to put it into action.  Today's guest, Dr. David Perlmutter is a board-certified neurologist and six-time New York Times bestselling author. His new book, Brain Defenders, dives into the groundbreaking discovery that immune cells in the brain are the key to brain health and longevity. On this episode, you're going to learn about this emerging science and what you can do to protect your brain now and as you age.  In this interview, you're going to learn about the fascinating science of immunometabolism, what microglial cells are, and the specific lifestyle habits that can shape the future of your brain. We're going to talk about specific foods and exercises that can dictate the health of your brain's immune cells, and proven strategies to protect your brain from degradation. Enjoy!  In this episode you'll discover: The one fundamental mechanism that connects all neurodegenerative diseases. (2:26) What the latest science says about the efficacy of Alzheimer's medications. (3:41) The essential function of microglial cells. (6:51)  What immunometabolism is. (8:41)  How having type 2 diabetes can increase your risk of Alzheimer's disease. (11:23) What GLP-1 drugs teach us about the link between the brain and metabolism. (12:12) How exercise helps defend the brain from degeneration. (29:12) The connection between myokines and metabolism. (29:54) Why flexibility and balance training are important for longevity. (36:57) The truth about fish oil supplements for brain health. (38:14) What to eat to defend your brain. (42:21) How eating ultraprocessed foods increases your risk of brain diseases. (45:38) Why stress impacts your brain health. (57:10) The simplest way to measure your health and activity levels. (1:08:23) Items mentioned in this episode include: DrinkLMNT.com/model - Get a truly meaningful dose of electrolytes in a science-backed ratio. Free sample pack with any order. Organifi.com/Model - Organifi makes nutrition easy and delicious for everyone. Take 20% off your order with the code MODEL. Brain Defenders by Dr. David Perlmutter - Preorder your copy of Dr. Perlmutter's new book today!  Grain Brain by Dr. David Perlmutter - Read about how your diet affects your brain health!  You've Been Pooping All Wrong by Dr. Trisha Pasricha - Learn about gut health and how to poop better!  Connect with Dr. David Perlmutter Website / Podcast / Facebook / Instagram  Be sure you are subscribed to this podcast to automatically receive your episodes:  Apple Podcasts Spotify Soundcloud Pandora YouTube  This episode of The Model Health Show is brought to you by LMNT and Organifi.  Most people are underhydrated—and it's costing you energy, focus, and performance. LMNT delivers a science-backed electrolyte ratio with no sugar, no junk—just what your body actually needs. Get a free sample pack with any order at drinklmnt.com/model.  Make nutrition effortless—and actually enjoyable. Organifi's delicious, superfood blends help you boost energy, reduce stress, and feel your best every day. Get 20% off with code MODEL at organifi.com/model. 

In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna discuss the mysterious death of Austria's Christian Pilnacek in October of 2023 with Dr.'s Sarah Schiffecker and David Perlmutter from Texas Tech University. Christian Pilnacek was a prominent Austrian lawyer and former judge who rose to become one of the most powerful officials in the country's Ministry of Justice before being suspended amid controversy. While his October 2023 death in a Danube tributary was quickly ruled a suicide, the circumstances remain surrounded by mystery due to allegations of a sloppy investigation and suspected political interference. Check out Dr. Schiffecker's work: ⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠⁠⁠⁠. Check out Dr. Perlmutter's work: ⁠⁠⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Kensington Publishing: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.kensingtonbooks.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Neurologist and bestselling author Dr. David Perlmutter returns to discuss the groundbreaking science behind his new book, Brain Defenders. Together, we unpack why Alzheimer's disease may be driven less by amyloid plaques and more by chronic inflammation, metabolic dysfunction, and changes in the brain's immune cells. Dr. Perlmutter explains the critical role of microglia, how blood sugar and insulin resistance affect the brain, why gut health is directly connected to cognitive function, and what lifestyle habits have the strongest evidence for protecting memory as we age. → Leave Us A Voice Message!  Topics Discussed: → What causes Alzheimer's disease? → How do you prevent Alzheimer'? → What foods improve brain health? → Can inflammation cause dementia? → Does blood sugar affect memory? Sponsored By:  → Function | Check your health the way I do. Function provides 160+ lab tests for $1/day and member pricing on advanced imaging. Join at https://functionhealth.com/bewellbykelly and use code BEWELL25 for a $25 credit. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Shop minnow's new apré-ski capsule collection at https://shopminnow.com and enter code MEETMINNOW15 at checkout to receive 15% off your first order. → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. → Branch Basics | Go to https://branchbasics.com/BEWELLPODCAST and use code: BEWELLPODCASTfor 15% off your first purchase.  Timestamps:  → 00:00:00 - Introduction → 00:03:07 - Why Alzheimer's Research Is Changing → 00:05:42 - Microglia Explained → 00:10:44 - Understanding Immunomatabolism  → 00:15:10 - Insulin Resistance + "Type 3 Diabetes" → 00:19:27 - Long COVID + Brain Recovery → 00:30:20 - Lifestyle Changes For Brain Health  → 00:35:22 - The Gut Microbiome → 00:37:27 - Tracking Gut Health  → 00:39:26 - Early Biomarkers/Testing  → 00:45:20 - Exercise + Muscle → 00:49:51 - Children's Nutrition  → 00:52:48 - Women's Dementia Risk   → 00:58:53 - GLP1s + Other Peptides   → 01:07:41 - Dr. Perlmutter's Daily Brain Health Routine Further Listening:  → Nutrition for a Healthy Brain & Body (Without Counting Calories) | Max Lugavere Check Out David: → Book | Braindefenders.com → Website → Instagram  Check Out Kelly: → Instagram → Youtube → Facebook

Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it. Get Dr. Perlmutter's new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience. Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation. You'll Learn: Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation How ketones, DHA, and metabolic health protect the brain after head injury Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity Resources: • Get Dr. Perlmutter's New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ • Learn More About Dr. Perlmutter's Work At: https://drperlmutter.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:40 – Intro 02:38 – Ultra-Processed Foods 06:34 – Are Carbs Bad? 08:48 – Alcohol & Brain Health 12:28 – Microglia & Inflammation 24:37 – Head Injury & Recovery 29:27 – Oral Bacteria & Dementia 34:08 – GLP-1s & Brain Inflammation 40:20 – 40 Hertz Light Therapy 48:35 – Air Pollution vs. Lead 50:27 – David's Closing Truth See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week, Scott sat down with his Lawfare colleagues Editor in Chief and co-host emeritus Benjamin Wittes and Senior Editors Anna Bower and Michael Feinberg to talk through the latest in national security news, including:“Humphrey's Executioner.” On June 29, the Supreme Court closed out its term with a trio of decisions on the president's power to fire officials at supposedly independent agencies. In Trump v. Slaughter, a 6–3 majority upheld Trump's firing of FTC Commissioner Rebecca Slaughter and overruled the 90-year-old precedent Humphrey's Executor, handing the president at-will removal power over roughly two dozen multimember agencies. The same day, in Trump v. Cook, the Court refused 5–4 to let Trump remove Federal Reserve Governor Lisa Cook, carving out a special exemption for the central bank. And a day later, in Blanche v. Perlmutter, the justices declined to let Trump oust Register of Copyrights Shira Perlmutter, whose office sits within the legislative branch. Taken together, what do these cases tell us about the unitary executive and the future of agency independence?“For Your Lies Only.” The Office of the Director of National Intelligence is in freefall. Since Bill Pulte—a housing-finance official with no intelligence background—took over as acting DNI on June 19, he has demanded a roster of every employee, fired the head of the office that oversees the President's Daily Brief, and all but liquidated the National Intelligence Council. The fight over his appointment has already cost the government its Section 702 surveillance authority, which lawmakers let lapse rather than leave in his hands, and Trump abruptly canceled the confirmation hearing for his own permanent nominee, Jay Clayton, to keep the “less shackled” Pulte in place. How did the nation's top intelligence coordinator get here—and how much damage can a politicized ODNI actually do?“Fixer Upper.” In one of the stranger turns of the Trump era, Michael Cohen—the former “fixer” whose testimony helped convict Trump of 34 felonies—says he and the president have reconciled. Cohen, who once vowed to flee the country if Trump won, said that the ice between them “didn't just melt, it broke,” and he is now taking a weekend slot on a conservative station with what he says was Trump's “glowing recommendation.” The thaw arrives as Trump's appeal of his New York conviction and related civil fraud judgment grind forward—and after Cohen publicly claimed he felt “pressured and coerced” to testify. What might Cohen's turn mean for that pending appeal?In object lessons, everyone is in a unifying mood. Ben demonstrates how RAGtime, his co-creation with AI overlord Claude to develop and analyze datasets, can find common cause between this week's co-hosts. Mike is enthusiastic about the new Criterion Collection bringing together all of Stanley Kubrick's works. Scott is reaching for perhaps humanity's greatest unifier—a certain beverage that can be enjoyed across political persuasions and coasts alike. And Anna is bringing us all to the world of personal essays with Jo Ann Beard's “The Fourth State of Matter.” To receive ad-free podcasts, become a Lawfare Material Supporter at www.patreon.com/lawfare. You can also support Lawfare by making a one-time donation at https://givebutter.com/lawfare-institute.Support this show http://supporter.acast.com/lawfare. Hosted on Acast. See acast.com/privacy for more information.

This week, Scott sat down with his Lawfare colleagues Editor in Chief and co-host emeritus Benjamin Wittes and Senior Editors Anna Bower and Michael Feinberg to talk through the latest in national security news, including:“Humphrey's Executioner.” On June 29, the Supreme Court closed out its term with a trio of decisions on the president's power to fire officials at supposedly independent agencies. In Trump v. Slaughter, a 6–3 majority upheld Trump's firing of FTC Commissioner Rebecca Slaughter and overruled the 90-year-old precedent Humphrey's Executor, handing the president at-will removal power over roughly two dozen multimember agencies. The same day, in Trump v. Cook, the Court refused 5–4 to let Trump remove Federal Reserve Governor Lisa Cook, carving out a special exemption for the central bank. And a day later, in Blanche v. Perlmutter, the justices declined to let Trump oust Register of Copyrights Shira Perlmutter, whose office sits within the legislative branch. Taken together, what do these cases tell us about the unitary executive and the future of agency independence?“For Your Lies Only.” The Office of the Director of National Intelligence is in freefall. Since Bill Pulte—a housing-finance official with no intelligence background—took over as acting DNI on June 19, he has demanded a roster of every employee, fired the head of the office that oversees the President's Daily Brief, and all but liquidated the National Intelligence Council. The fight over his appointment has already cost the government its Section 702 surveillance authority, which lawmakers let lapse rather than leave in his hands, and Trump abruptly canceled the confirmation hearing for his own permanent nominee, Jay Clayton, to keep the “less shackled” Pulte in place. How did the nation's top intelligence coordinator get here—and how much damage can a politicized ODNI actually do?“Fixer Upper.” In one of the stranger turns of the Trump era, Michael Cohen—the former “fixer” whose testimony helped convict Trump of 34 felonies—says he and the president have reconciled. Cohen, who once vowed to flee the country if Trump won, said that the ice between them “didn't just melt, it broke,” and he is now taking a weekend slot on a conservative station with what he says was Trump's “glowing recommendation.” The thaw arrives as Trump's appeal of his New York conviction and related civil fraud judgment grind forward—and after Cohen publicly claimed he felt “pressured and coerced” to testify. What might Cohen's turn mean for that pending appeal?In object lessons, everyone is in a unifying mood. Ben demonstrates how RAGtime, his co-creation with AI overlord Claude to develop and analyze datasets, can find common cause between this week's co-hosts. Mike is enthusiastic about the new Criterion Collection bringing together all of Stanley Kubrick's works. Scott is reaching for perhaps humanity's greatest unifier—a certain beverage that can be enjoyed across political persuasions and coasts alike. And Anna is bringing us all to the world of personal essays with Jo Ann Beard's “The Fourth State of Matter.” To receive ad-free podcasts, become a Lawfare Material Supporter at www.patreon.com/lawfare. You can also support Lawfare by making a one-time donation at https://givebutter.com/lawfare-institute. Hosted on Acast. See acast.com/privacy for more information.

Immune Regulation, Omega-3 Nuance, and Himalayan Tartary Buckwheat with Dr. Austin Perlmutter, chief science officer of Big Bold Health. He details immune regulation as a nuanced, multidimensional system shaped by diet and lifestyle rather than simple “boosting.” Perlmutter explains Big Bold Health's focus on immunometabolism, educating about immune complexity, and conducting studies on nutraceuticals, including use of CGMs and clinical trials. He discusses why eating fish often outperforms refined fish-oil supplements, noting conventional processing (heat, bleaching, deodorizing, esterification) and loss of other lipids and nutrients. Perlmutter highlights specialized pro-resolving mediators (resolvins, protectins, maresins) and vitamins A and D as potentially better preserved in minimally processed oils, and reviews typical omega-3 intake and target ranges. The conversation also covers immunosenescence/inflammaging and Big Bold Health research on sprouted Himalayan Tartary Buckwheat, its high polyphenols (rutin, quercetin), microbiome effects, and studies including epigenetic aging clocks and brain outcomes.

Dr. David D. Perlmutter and Julie Brannan return again to talk about Steven Spielberg's Disclosure Day movie. Spoilers ahead!

In this new episode, Crawlspace Media's Tim Pilleri and Lance Reenstierna speak with Dr.'s Sarah Schiffecker and David Perlmutter about the media circus surrounding the Karen Read case. In this episode, we explore the complex case of Karen Reed, media coverage, and the impact of technology on justice. Our experts discuss media circus, social media influence, and the evolving standards of evidence in criminal justice. Check out Dr. Schiffecker's work: ⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠⁠⁠. Check out Dr. Perlmutter's work: ⁠⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠. Check out Kensington Publishing: ⁠⁠⁠⁠⁠⁠https://www.kensingtonbooks.com⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠. TT:⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Sci-fi has taken many forms as a genre, and since it happens to be a genre that both Dr. Perlmutter and Chris have an affinity for, why not cover one of the true classics. While those who saw Forbidden Planet in theaters may not have realized that it was merely an amuse bouche for the more pop culture pliable Star Trek, the film is definitely one worth talking about and reappraising from a modern-day perspective.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.

The countdown reaches the most divisive Avengers title. Adam makes the case that Avengers: Age of Ultron isn't a bad movie so much as a conflicted one, the first Marvel tentpole that put serving the wider universe ahead of being its own thing. Along the way: the tonal whiplash that kills every death scene, the Whedon dialogue problem, and a deep dive into how the Agents of SHIELD and Inhumans experiment, a Perlmutter mandate born of X-Men envy, was the original dry run for the "homework" problem that would later sink the Multiverse Saga. A solid but bottom-of-the-Avengers 4 out of 5. Next week: Civil War.

We're running it back with some films we've already watched with a Robert Eggers film that has become a modern day classic: The VVitch. Starring Anya-Taylor Joy as Thomasin, she along with her family live in 1630s New England which may or may not be under the sway of a witch in the woods. Thomasin and her family are doomed to find out whether or not the witch is real or not. Dr. David. D. Perlmutter and Julie Brannan join the episode to talk all about it.Become a supporter of this podcast: https://www.spreaker.com/podcast/the-kulturecast--2883470/support.

Why They Disappeared: Coping with Ghosting & Betrayal with Gretta PerlmutterHave you ever been left on "read" forever? In modern dating, few things are as frustrating or painful as a sudden, unexplained ending. In this episode of the Cupid's Coach Podcast, host Julie Ferman welcomes Gretta Perlmutter, a Certified Post Betrayal Transformation® Coach and host of the Coping With Ghosting podcast. Gretta shares her professional expertise and personal journey through "ghosting on repeat" to help you understand why people disappear and how to reclaim your peace of mind.Julie and Gretta break down the distinction between breaking a "social contract" and healthy self-protection, while exploring the surprising statistics that show ghosting is a multi-generational trend. Whether you're dealing with a "micro-ghost" on an app or a disappearance after a real date, this episode provides the courageous communication tools you need to move from victimhood to closure.Inside this Episode:Defining Ghosting: Why withdrawing without explanation is different from leaving an abusive situation.The Ghosting Stats: A look at why women (55%) are actually more likely to admit to ghosting than men (46%).Accidental vs. Intentional: Distinguishing between a lost phone and a lack of moral fiber or vulnerability.The "Obituary" Phase: Moving past the urge to Google why they stopped texting.Courageous Communication: Practical scripts for checking in on a date and how to end things respectfully.The Healing Journey: Why your value doesn't depend on a ghost's approval.Connect with Gretta Perlmutter: Explore resources and coaching at CopingWithGhosting.com.Connect with Julie Ferman: Ready to find a person who will never ghost you? Register for free matchmaking at JulieFerman.com.#CupidsCoach #GrettaPerlmutter #Ghosting #BetrayalHealing #DatingAdvice #RelationshipBetrayal #Closure #PostBetrayalTransformation

In this episode, Crawlspace Media's Tim Pilleri & Lance Reenstierna are joined by Dr. Sarah Schiffecker & Dr. David Perlmutter to try to solve the coldest murder in history. The discussion takes them back 5,300 years to the Italian Alps, where the legendary Ötzi became the victim of the worlds oldest documented murder. This conversation centers around questions of motive, means and opportunity. This episode was previously published on Crawlspace on March 29th, 2026. More on Ötzi: https://en.wikipedia.org/wiki/Ötzi. Check out Dr. Schiffecker's work: ⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠⁠ Check out Dr. Perlmutter's work: ⁠⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠ Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠. Spotify:⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠. TT:⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠. FB:⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠. X:⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠ Spotify:⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠. Youtube:⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠. Apple:⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠. Check out our entire network at⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 3250 of the Vietnam Veteran News Podcast will feature a story about Vietnam Vet Leo Perlmutter finally receiving his medals for the Vietnam War. The featured story is titled: Delayed Purple Heart Awarded To Vietnam Veteran It appeared on … Continue reading → The post Episode 3250 –  Vietnam Vet Leo Perlmutter finally received his Vietnam Medals first appeared on Vietnam Veteran News.

In this new episode, ⁠Crawlspace Media⁠'s Tim Pilleri and Lance Reenstierna speak with Dr's Sarah Schiffecker and David Perlmutter from Texas Tech University about the mysterious disappearance of Air Force General William Neil McCasland from his home in Albuquerque, New Mexico on February 27th, 2026. If you have any information in General McCasland's disappearance, please text BCSO to 847411 or call 505-468-7070. Dr. Schiffecker's faculty page: https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php. Dr. Perlmutter's faculty page: https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out Mint Mobile: ⁠⁠⁠⁠mintmobile.com/missing⁠⁠⁠⁠. We have an upcoming live show with Another F*cking Horror Podcast! It's called Criminally Stupid - The Search For the World's Dumbest Criminal. For tickets, go to: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.eventbrite.com/e/criminally-stupid-the-search-for-the-worlds-dumbest-criminal-tickets-1984625623665⁠⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia. Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time. Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more. Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience. Join us as we delve into: What microglia are and why they control brain health The difference between M1 (destructive) and M2 (protective) states How metabolism shapes the brain's immune response Why conditions like Alzheimer's are rooted in immune dysfunction The connection between blood sugar, insulin, and brain degeneration This episode is for you if: You want to protect your brain and prevent cognitive decline You're interested in the science of Alzheimer's and neurodegeneration You want actionable strategies to improve brain health You're curious about the future of brain optimization and longevity You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/ Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are once again joined by Dr. Sarah Schiffecker & Dr. David Perlmutter. Their conversation takes them back 5,300 years to the Italian Alps, where the legendary Ötzi became the victim of the worlds oldest documented murder. After his discovered in 1991, the questions of motive, means and opportunity remain an elusive enigma. WE HAVE A LIVE SHOW WITH THE SHOW, ANOTHER F*CKING HORROR PODCAST. IT'S CALLED: CRIMINALLY STUPID - THE SEARCH FOR THE WORLDS DUMBEST CRIMINAL. FOR TICKETS, GO TO: ⁠⁠https://www.eventbrite.com/e/criminally-stupid-the-search-for-the-worlds-dumbest-criminal-tickets-1984625623665⁠ Check out Dr. Schiffecker's work: ⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠⁠ Check out Dr. Perlmutter's work: ⁠⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠⁠ Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. The music for Crawlspace was produced by David Flajnik. Listen to his music here: ⁠⁠⁠⁠⁠⁠https://www.pond5.com/artist/bigdsound.⁠⁠⁠⁠⁠ Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. David D. Perlmutter and Julie Brannan return to lend their insights into the 2025 conspiracy film Bugonia. This movie has so many references to modern day conspiracy culture, it takes the three of us to unpack!

One of the most polarizing questions in the mind of any photographer is "Should—or shouldn't I—get an agent?"  The role of an agent in a photographer's career is often misunderstood, leading hungry creatives to think that securing representation is their number one key to success. In truth, the relationship between a photographer and agent is far more nuanced than simply booking more assignments. In today's podcast, we take a deep dive into this complex alliance in a discussion with two generations of top agents, whose combined careers span from the film-era to the latest in media buys.  Listen in for a behind-the-scenes look at the many details involved, from the four P's Jennifer (JP) Perlmutter looks for in a photographer's work to Michael Ash's skill in editing a portfolio to allow a photographer's individual vision and passion to shine. Our experts also shed light on critical topics such as branding, while making distinctions between a physical and emotional brand. Get fresh insights about standing out in an oversaturated marketplace and the matter of seeing ahead of the curve on trends. As JP notes, "You don't have to hop on the current trend. You don't need to create the new trend. You need to create what's true to you, what's true to your vision, and then know that there are enough people out there—that there is your niche. There are the people who are going to love what you're doing." Guests: Jennifer Perlmutter & Michael Ash Episode Timeline: 3:16: Is there a difference between the terms agent and rep? 4:11: Michael Ash on his start as an agent in late 1970's New York. 7:46: Jennifer Perlmutter talks about her beginnings at the dawn of social media. 12:25: Having a good eye for talent, plus the qualifications and skillsets needed to be a rep.  16:54: Producing as part of an agent's role, plus a peek inside relationships between photographers and a rep. 20:16: Navigating connections between clients, photographers, and reps—plus contracts. 27:34: An agent's role in protecting a photographer's interests, plus their skill in editing and curating the work. 35:46: JP describes the Four P's—what she looks for in a photographer's work. 43:14: Episode Break 44:36: To brand or not to brand, plus distinctions between physical and emotional branding.  47:28: How do you stand out in an oversaturated marketplace and hone a unique vision? 53:29: The current trend for nostalgia and harkening back to the analog world.  57:56: Michael and JP discuss today's advertising marketplace and usage rates.  1:01:08: The matter of taste vs analytics in today's commercial marketplace. 1:04:21: How do you see ahead of the curve or know which trends are worth jumping on? Where do we go from here? 1:11:14: Apostrophe's mentorship program, advice for young creatives, and some thoughts on AI. Guest Bios: Michael Ash is a photographers' agent and creative consultant who began representing photographers in 1979, after failing to get drafted into Major League Baseball. Born in Brownsville, Brooklyn, and raised on the streets of New York, Michael founded and led a successful agency in New York City from 1979 to 2016, focused on guiding the careers of more than 40 photographers from around the globe. He introduced this international talent to the world of commercial photography through representation, creative direction, and mentorship. Michael is an expert in contract negotiation, editorial curation, and client development. Most importantly, he has a lifelong dedication to nurturing artistic vision and unique creativity. Jennifer "JP" Perlmutter is currently a senior photo and motion rep at Apostrophe, with nearly two decades of experience representing and producing for photographers and directors across commercial and editorial realms. A 2006 graduate of Emerson College, where she studied advertising and visual arts, JP fell in love with photography early on and built a career at the intersection of creativity and commerce. She's known for her collaborative approach, sharp production insight, and deep commitment to artist development, especially when it comes to mentoring emerging talent. Possessing a robust skill set that includes artist representation, marketing strategy, photography, print production, social media and more, JP has built meaningful connections between artists, agencies, and brands, helping creatives collaborate authentically and thrive. She's passionate about championing visual storytellers and creating space for new voices in an ever-evolving industry. Stay Connected: Michael Ash on Instagram: https://www.instagram.com/michaelash_original/  Michael Ash on LinkedIn: https://www.linkedin.com/in/michaelash2/  Jennifer Perlmutter on Instagram: https://www.instagram.com/jnperl/  Jennifer Perlmutter on LinkedIn: https://www.linkedin.com/in/jperlmutter/  Apostrophe Reps Website: https://apostrophe.is/  Apostrophe Reps on Instagram: https://www.instagram.com/apostrophereps/  Credits: Host: Derek Fahsbender Senior Creative Producer: Jill Waterman Senior Technical Producer: Mike Weinstein Executive Producer: Dana Glidden  

Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined by friend of the show, Dr. David Perlmutter and new friend of the show Dr. Sarah Schiffecker. The two break down the nuances of the recent tragedy that occurred near the summit of Austria's highest mountain, Grossglockner. How does a culture rich in climbing and conquering these majestic heights, come to terms with toxic masculinity, national pride and willful neglect? Video of Grossglockner lights courtesy of: ⁠https://www.wcvb.com/article/austria-grossglockner-manslaughter-sentence/70430714⁠ Check out Dr. Schiffecker's work: ⁠https://www.depts.ttu.edu/comc/faculty/faculty/sschiffecker.php⁠ Check out Dr. Perlmutter's work: ⁠⁠⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠⁠⁠ Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. The music for Crawlspace was produced by David Flajnik. Listen to his music here: ⁠⁠⁠⁠⁠https://www.pond5.com/artist/bigdsound.⁠⁠⁠⁠ Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this new episode, Crawlspace Media's Tim Pilleri & Lance Reenstierna are joined once again by friend of the show and expert in all things media + crime related, Dr. David Perlmutter. As the clock continues to tick on the abduction of Nancy Guthrie, Dr. Perlmutter helps to break down how the media releases information, what is important for the public to know and what's important for the public to not know. If you have any information please submit a tip to the FBI at 1-800-225-5324. You could also submit a tip here: ⁠https://tips.fbi.gov/home⁠. More info: ⁠https://www.fbi.gov/wanted/kidnap/nancy-guthrie⁠. Savannah's Instagram video: ⁠https://www.instagram.com/p/DUW3mpqD8qd⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠. Main podcast theme by Kevin Macleod. Check out his work at⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://incompetech.com/⁠⁠⁠⁠⁠⁠. Additional music by David Williams. See his work at⁠⁠⁠⁠ ⁠⁠http://williamsflutes.com⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠. TT:⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠. Follow Crawlspace: IG:⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠. TT:⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠. FB:⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠. X:⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠. Apple:⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome back to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are joined once again by friend of the show and expert in all things media + crime related, Dr. David Perlmutter. As the clock continues to tick on the abduction of Nancy Guthrie, Dr. Perlmutter helps to break down how the media releases information, what is important for the public to know and what's important for the public to not know. Nancy Guthrie was taken from her home in Catalina Foothills, Arizona on February 1st, 2026. Nancy is the mother of well known broadcaster Savannah Guthrie. If you have any information please submit a tip to the FBI at 1-800-225-5324. You could also submit a tip here: ⁠⁠https://tips.fbi.gov/home⁠⁠. More info: ⁠⁠https://www.fbi.gov/wanted/kidnap/nancy-guthrie⁠⁠. Savannah's Instagram video: ⁠⁠https://www.instagram.com/p/DUW3mpqD8qd⁠⁠. Check out Quince: ⁠⁠⁠⁠⁠⁠⁠⁠https://quince.com/MISSING⁠⁠⁠⁠⁠⁠⁠⁠. The music for Crawlspace was produced by David Flajnik. Listen to his music here: https://www.pond5.com/artist/bigdsound. Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠. Follow Missing: IG: ⁠⁠⁠⁠⁠https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain's immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer's Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan. Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens. You'll Learn: • How microglia shift between supportive and destructive states and why metabolism drives that change • How mitochondrial function inside immune cells influences inflammation and brain resilience • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain Resources: • Learn More About Dr. Perlmutter at: https://drperlmutter.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:45 - Autism Spectrum 4:38 - Alzheimer's & Beta Amyloid 7:02 - Brain Immune Cells 8:06 - GLP-1 & Parkinson's 10:44 - M1 vs M2 Microglia 13:08 - Pharmaceutical Microdosing 15:51 - Gene Therapy 19:09 - Mold & Toxins 21:58 - Environmental Pollution 26:05 - MPTP Discovery 29:07 - Healing Interventions 31:39 - Light & Sound Therapy 36:35 - Mitochondrial Function 44:57 - Inflammation & Prefrontal Cortex 48:00 - GLP-1 Global Impact 52:11 - Mitochondrial Community 56:05 - Consciousness & The Field 1:00:00 - Psychedelics 1:01:59 - Love & Judgment 1:06:35 - Death & Knowing 1:09:06 - Heart-Brain Connection 1:11:06 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome to Crawlspace. In this new episode, Tim Pilleri & Lance Reenstierna are again joined old friend of the show, Dr. David Perlmutter. The topic this week is trying to understand the killings of Brown University students Mukhammad Aziz Umurzokov and Ella Cook & MIT professor Dr. Nuno Loureiro. Check out Dr. Perlmutter's work: ⁠https://www.depts.ttu.edu/comc/faculty/faculty/dperlmutter.php⁠ Follow Crawlspace: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/Crawlspacepodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/crawlspacepod.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/7iSnqnCf27NODdz0pJ1GvJ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/crawlspace⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/crawlspace-true-crime-mysteries/id1187326340⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Missing: IG:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/MissingCSM/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. TT:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. FB:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. X:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://twitter.com/MissingCSM⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://open.spotify.com/show/0yRXkJrZC85otfT7oXMcri⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Youtube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/missingcsm⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://podcasts.apple.com/us/podcast/missing/id1006974447⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Follow Private Investigations For the Missing Please donate if you can: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://investigationsforthemissing.org/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://piftm.org/donate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/PIFortheMissing⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/PIFortheMissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/investigationsforthemissing/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Check out our entire network at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ http://crawlspace-media.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Learn more about your ad choices. Visit megaphone.fm/adchoices