Podcasts about Severity

Description: Psoriatic disease affects far more than just the skin. Hear leading dermatologist Dr. April Armstrong and Dr. Benoît Guérrette discuss this and more with Jensen, a patient advocate. Psoriatic disease affects not only the skin but it can impact confidence, emotional and social well-being, and daily life. In this episode, join moderator Dr. Guy Eakin, Chief Scientific and Medical Officer at NPF, as we explore the disconnect between clinical classifications of psoriasis and what patients experience in real-life with leading dermatologist Dr. April Armstrong, Dr. Benoît Guérrette, Vice President of Dermatology & Rheumatology at Takeda, and Jensen, a NPF patient advocate and former Lead Youth Ambassador. Listen as we address the need for a more nuanced approach to classifying disease severity that accounts for the holistic needs of psoriatic disease, as well as share insights into how advocacy and awareness can drive change in treatment access and care standards.  The intent of this episode is to identify how clinical severity classifications of psoriasis are evolving to meet the needs of those who live with the disease and how that change impacts overall management. This episode is sponsored by Takeda. Timestamps: (0:00) Intro to Psoriasis Uncovered and guest welcome to dermatologist Dr. April Armstrong, Vice President of Takeda, Dr. Benoît Guérette, and patient advocate Jensen, who discuss the unmet needs of people with moderate psoriasis and how as a community we can better serve those living with the disease. 2:22 How health care providers and the biopharmaceutical industry are coming together to address systemic eligibility and the unmet needs of people living with psoriasis. 4:25 Quality of life should be included when assessing clinical severity in psoriasis and identification of appropriate treatment choices. 6:52 The impact of misdiagnosis, inappropriate treatment, and effect on high impact sites can be life- altering. 8:30 How appropriate treatment and knowledge can make all the difference when diagnosed with plaque psoriasis.  9:40 Views on the psoriasis disease classification system and how it's evolving to include real life impact from physical and emotional needs, to more personalized care for those living with psoriasis, even when small body surface areas are involved. Severity isn't defined by skin coverage alone. 12:38 What's needed to prioritize the care and outcomes of people living with psoriasis. 14:18  The future of management and care for psoriatic disease. 15:53  "My skin tells a story." Wisdom from what I wish I had known previously. 16:52  Moving closer to care that truly reflects the lives and needs of those who live with psoriasis. Key Takeaways: ·       Severity of psoriasis isn't defined by skin coverage or body surface area (BSA) alone. The impact on quality of life should also be considered in the assessment, selection of treatment, and management of the disease.  ·       The psoriasis disease classification system is evolving to be more of a patient centered approach.  Many clinicians are now using the International Psoriasis Council (IPC) or 2 bucket approach to identify whether someone should receive a topical or systemic treatment based on location and response to treatment, as well as impact on quality of life.  ·       With continued research and  development, the next 5 to 10 years could see a shift in effective treatment options while also treating sooner to initiate better outcomes for people living with psoriasis and psoriatic arthritis. Guest Bios:   April Armstrong, M.D., M.P.H. is an internationally renowned dermatologist and clinical researcher who is a Professor and Chief of Dermatology at the University of California Los Angeles (UCLA) where she specializes in inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa (HS). Dr. Armstrong is also the Co-Director for Network Resources at the UCLA Clinical and Translational Research Institute. She has conducted over 150 clinical trials and published over 350 high impact articles in scientific journals. Dr. Armstrong holds multiple leadership positions including the immediate Past Chair of the National Psoriasis Foundation Medical Board, Co-President of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), councilor for the International Psoriasis Council, and board member for the International Dermatology Outcome Measures and the American Academy of Dermatology.  Benoît Guérette, Ph.D. is an accomplished leader in medical affairs with extensive experience across academia and the pharmaceutical industry. Since March 2025, Dr. Guérette has served as Vice President of Dermatology and Rheumatology US Medical Affairs at Takeda Pharmaceutical. Prior to joining Takeda, he held several strategic and leadership roles at various pharmaceutical companies, including overseeing clinical development, global and U.S. medical affairs, global access & pricing, translational sciences and more. Before transitioning to the industry, Dr. Guérette was an Associate Professor of Immunology at Laval University, leading research in cancer immunology. He holds a Ph.D. in Medicine, Microbiology, and Immunology from Laval University and completed postdoctoral studies in Inflammation and Immunology at  Harvard Medical School.  Jensen is a volunteer and former Lead Youth Ambassador for the National Psoriasis Foundation. Jensen developed psoriasis at age 7 but wasn't formally diagnosed until age 14 being misdiagnosed along the way, trying different management approaches that were ineffective. She was a competitive swimmer from elementary through high school and in the last 2 years of high school played lacrosse. Upon finishing high school she attended college becoming a registered nurse in an intensive care unit. Jensen wants "youth living with psoriatic disease to feel a  community that is behind them and with them every step of the way. I really want to be able to make a difference in a way that would've helped me as a child when I was diagnosed." Resources: Ø  "Reassessing Psoriasis Severity" Advance Online, National Psoriasis Foundation. H. Onorati. January 16, 2024,  https://www.psoriasis.org/advance/psoriasis-severity-high-impact-sites/   Ø  "Psoriasis Involving Special Areas is Associated with Worse Quality of Life, Depression, and Limitations in the Ability to Participate in Social Roles and Activities". Blauvelt, A., Strober, B., Gondo, G., Journal of Psoriasis and Psoriatic Arthritis Volume 8, Issue 3.  https://journals.sagepub.com/doi/full/10.1177/24755303231160683

Series - Romans: Guilt Grace & Gratitude pt. 81 Text: 11:21-24 by Nick Neves, pastor | Lord's Day Morning | 11.30.25

Last Decades, Persistent Pain, and Final Rest — Ronald White — In his later years, the severity of Chamberlain's Civil War wound, which he largely concealed, became public through a newspaper account of his surgery. He attempted business ventures without success, realizing his true calling lay in service to others. Remaining active into his 80s, he traveled extensively, impressively reading the Quran in Arabic and the Bible in Greek. Chamberlain died in 1914, essentially becoming the last casualty of the Civil War due to his Petersburgwound. Share

Erie County Executive Mark Poloncarz introduces a new website for winter storm severity full 1715 Fri, 21 Nov 2025 19:20:44 +0000 FDjPtumbHypp2cS2IiREOZVFISYnHOrb news & politics,news WBEN Extras news & politics,news Erie County Executive Mark Poloncarz introduces a new website for winter storm severity Archive of various reports and news events 2024 © 2021 Audacy, Inc. News & Politics News False https

Main Theme: The message continues the study of Joshua chapters 10–11, exploring how God led Israel to fully conquer their enemies. Pastor emphasized that these natural battles symbolize our spiritual warfare—the believer's call to finish battles of faith, destroy sin's influence, and walk in victory through obedience. Opening and Global Prayer The service began with intercession for Christians under persecution in Nigeria and Sudan, highlighting that while Western believers face spiritual battles, others face literal physical danger for their faith. Pastor led prayer for God's mercy, protection, and bold witness among the persecuted church. Israel's Battle and Spiritual Parallels (Joshua 10:16–43) Joshua commanded the army to seal the five kings in the cave at Makkedah, pursue the enemy, and finish the battle. After victory, Joshua had his captains place their feet on the necks of the kings—a prophetic act of dominion. This became a picture of spiritual warfare: “Sometimes we don't finish the battle. We let things live that God told us to destroy.” Believers must pursue sin and temptation until they are “dust under our feet.” Partial obedience leads to future bondage. Lesson: Don't leave sin alive. Whatever is not put to death will eventually come back to destroy. Just as Joshua completed every battle, we must close every spiritual door and cut off access to the enemy. God's Ways and the Danger of Presumption Pastor reminded the congregation that God moves in diverse ways: “Sometimes He fights supernaturally; other times He works through natural means or people—but it's always His hand.” He warned against putting God in a box or expecting Him to act the same way every time, which leads to a Pharisaical mindset. True faith trusts His sovereignty regardless of method. The Severity of Sin Joshua's command to destroy the Canaanite nations often troubles modern readers, but Pastor explained: God owns everything; He is perfectly just in judgment. Israel's destruction of wicked nations demonstrates the seriousness of sin, not cruelty. “We don't see how wicked sin really is… we've redefined it as conditions or sickness instead of rebellion against God.” Sin caused death, chaos, and even required the crucifixion of God's Son to be redeemed. God's judgment isn't biased—He later judged Israel the same way when they turned to idolatry. “He's long-suffering, but He's also holy.” God the Redeemer Pastor used the analogy of the pawn shop and Hosea's marriage: Humanity belonged to God but sold itself to sin. Yet God, though rightful owner, paid again with the blood of Christ to buy us back. “He walked into the spiritual pawn shop and paid for the whole store.” This is the picture of grace: redemption at a cost God didn't owe. Spiritual Warfare and Finishing the Fight (Joshua 11) The northern kings united against Israel, but God reassured Joshua: “Do not be afraid. I will deliver them into your hand.” God again fought for Israel, proving that obedience keeps God's presence active. Joshua's faithfulness to continue Moses' commands showed continuity—obedience to divine instruction brings sustained victory. Application: Romans 6 and the War Within Pastor connected Joshua's battles to Romans 6, explaining how believers must fight sin with the same intensity: “Shall we continue in sin that grace may abound? God forbid.” Through baptism, we are united with Christ's death and resurrection. Therefore, sin has no dominion over believers: “Even when you fail, your position in Christ overrides your condition.” Victory comes by renewing the mind with the Word, speaking God's truth over ourselves, and closing every door to sin. Believers must “cut off options” that lead back to bondage—relationships, habits, or influences that tempt the flesh. Becoming a Bondservant Paul called himself a bondslave of Christ—one who chooses to stay out of love, not compulsion. Pastor contrasted this with modern Christians who seek convenience: “Christianity isn't weakness—it's surrender. The greatest opportunity isn't success, it's becoming a man or woman of God.” Closing Exhortation God desires full victory for His people—no compromise, no partial obedience. The Christian walk is discipleship as a journey, not a destination. Every battle is an opportunity to grow stronger in faith and obedience. “Cut off what tempts you. Pursue your enemies until they're dust under your feet. You are dead to sin and alive to God. Finish the fight.” Core Message Don't leave sin alive—finish the battle. God's justice reveals the true horror of sin. You are redeemed at great cost—live as one who's been bought back. Renew your mind, close every door to the enemy, and walk in your position in Christ. The greatest victory is not survival—it's surrender.

Co-hosts Ryan Piansky, a graduate student and patient advocate living with eosinophilic esophagitis (EoE) and eosinophilic asthma, and Holly Knotowicz, a speech-language pathologist living with EoE who serves on APFED's Health Sciences Advisory Council, interview Evan S. Dellon, MD, and Elizabeth T. Jensen, PhD, about a paper they published on predictors of patients receiving no medication for treatment of eosinophilic esophagitis. Disclaimer: The information provided in this podcast is designed to support, not replace, the relationship between listeners and their healthcare providers. Opinions, information, and recommendations shared in this podcast are not a substitute for medical advice. Decisions related to medical care should be made with your healthcare provider. Opinions and views of guests and co-hosts are their own.   Key Takeaways: [:52] Co-host Ryan Piansky introduces the episode, brought to you thanks to the support of Education Partners GSK, Sanofi, Regeneron, and Takeda. Ryan introduces co-host Holly Knotowicz.   [1:14] Holly introduces today's topic, predictors of not using medication for EoE, and today's guests, Dr. Evan Dellon and Dr. Elizabeth Jensen.   [1:29] Dr. Dellon is an Adjunct Professor of Epidemiology at the University of North Carolina School of Medicine in Chapel Hill. He is also the Director of the UNC Center for Esophageal Diseases and Swallowing.   [1:42] Dr. Dellon's main research interest is in the epidemiology, pathogenesis, diagnosis, treatment, and outcomes of eosinophilic esophagitis (EoE) and eosinophilic GI diseases (EGIDs).   [1:55] Dr. Jensen is a Professor of Epidemiology with a specific expertise in reproductive, perinatal, and pediatric epidemiology. She has appointments at both Wake Forest University School of Medicine and the University of North Carolina at Chapel Hill.   [2:07] Her research primarily focuses on etiologic factors in the development of pediatric immune-mediated chronic diseases, including understanding factors contributing to disparities in health outcomes.   [2:19] Both Dr. Dellon and Dr. Jensen also serve on the Steering Committee for EGID Partners Registry.   [2:24] Ryan thanks Dr. Dellon and Dr. Jensen for joining the podcast today.   [2:29] Dr. Dellon was the first guest on this podcast. It is wonderful to have him back for the 50th episode! Dr. Dellon is one of Ryan's GI specialists. Ryan recently went to North Carolina to get a scope with him.   [3:03] Dr. Dellon is an adult gastroenterologist at the University of North Carolina at Chapel Hill. He directs the Center for Esophageal Diseases and Swallowing. Clinically and research-wise, he is focused on EoE and other eosinophilic GI diseases.   [3:19] His research interests span the entire field, from epidemiology, diagnosis, biomarkers, risk factors, outcomes, and a lot of work, more recently, on treatments.   [3:33] Dr. Jensen has been on the podcast before, on Episode 27. Holly invites Dr. Jensen to tell the listeners more about herself and her work with eosinophilic diseases.   [3:46] Dr. Jensen has been working on eosinophilic gastrointestinal diseases for about 15 years. She started some of the early work around understanding possible risk factors for the development of disease.   [4:04] She has gone on to support lots of other research projects, including some with Dr. Dellon, where they're looking at gene-environment interactions in relation to developing EoE.   [4:15] She is also looking at reproductive factors as they relate to EoE, disparities in diagnosis, and more. It's been an exciting research trajectory, starting with what we knew very little about and building to an increasing understanding of why EoE develops.   [5:00] Dr. Dellon explains that EoE stands for eosinophilic esophagitis, a chronic allergic condition of the esophagus.   [5:08] You can think of EoE as asthma of the esophagus or eczema of the esophagus, although in general, people don't grow out of EoE, like they might grow out of eczema or asthma. When people have EoE, it is a long-term condition.   [5:24] Eosinophils are a type of white blood cell, specializing in allergy responses. Normally, they are not in the esophagus. When we see them there, we worry about an allergic process. When that happens, that's EoE.   [5:40] Over time, the inflammation seen in EoE and other allergic cell activity causes swelling and irritation in the esophagus. Early on, this often leads to a range of upper GI symptoms — including poor growth or failure to thrive in young children, abdominal pain, nausea, and symptoms that can mimic reflux.   [5:58] In older kids, symptoms are more about trouble swallowing. That's because the swelling that happens initially, over time, may turn into scar tissue. So the esophagus can narrow and cause swallowing symptoms like food impaction.   [6:16] Ryan speaks of living with EoE for decades and trying the full range of treatment options: food elimination, PPIs, steroids, and, more recently, biologics.   [6:36] Dr. Dellon says Ryan's history is a good overview of how EoE is treated. There are two general approaches to treating the underlying condition: using medicines and/or eliminating foods that we think may trigger EoE from the diet.   [6:57] For a lot of people, EoE is a food-triggered allergic condition.   [7:01] The other thing that has to happen in parallel is surveying for scar tissue in the esophagus. If that's present and people have trouble swallowing, sometimes stretching the esophagus is needed through esophageal dilation.   [7:14] There are three categories of medicines used for treatment. Proton pump inhibitors are reflux meds, but they also have an anti-allergy effect in the esophagus.   [7:29] Topical steroids are used to coat the esophagus and produce an anti-inflammatory effect. The FDA has approved a budesonide oral suspension for that.   [7:39] Biologics, which are generally systemic medications, often injectable, can target different allergic factors. Dupilumab is approved now, and there are other biologics that are being researched as potential treatments.   [7:51] Even though EoE is considered an allergic condition, we don't have a test to tell people what they are allergic to. If it's a food allergy, we do an empiric elimination diet because allergy tests aren't accurate enough to tell us what the EoE triggers are.   [8:10] People will eliminate foods that we know are the most common triggers, like milk protein, dairy, wheat, egg, soy, and other top allergens. You can create a diet like that and then have a response to the diet elimination.   [8:31] Dr. Jensen and Dr. Dellon recently published an abstract in the American Journal of Gastroenterology about people with EoE who are not taking any medicine for it. Dr. Jensen calls it a real-world data study, leveraging electronic health record patient data.   [8:51] It gives you an impression of what is actually happening, in terms of treatments for patients, as opposed to a randomized control trial, which is a fairly selected patient population. This is everybody who has been diagnosed, and then what happens with them.   [9:10] Because of that, it gives you a wide spectrum of patients. Some patients are going to be relatively asymptomatic. It may be that we arrived at their diagnosis while working them up for other potential diagnoses.   [9:28] Other patients are going to have rather significant impacts from the disease. We wanted to get an idea of what is actually happening out there with the full breadth of the patient population that is getting diagnosed with EoE.   [9:45] Dr. Jensen was not surprised to learn that there are patients who had no pharmacologic treatment.   [9:58] Some patients are relatively asymptomatic, and others are not interested in pursuing medications initially or are early in their disease process and still exploring dietary treatment options.   [10:28] Holly sees patients from infancy to geriatrics, and if they're not having symptoms, they wonder why bother treating it.   [10:42] Dr. Jensen says it's a point of debate on the implications of somebody who has the disease and goes untreated. What does that look like long-term? Are they going to develop more of that fibrostenotic pattern in their esophagus without treatment?   [11:07] This is a question we're still trying to answer. There is some suggestion that for some patients who don't manage their disease, we very well may be looking at a food impaction in the future.   [11:19] Dr. Dellon says we know overall for the population of EoE patients, but it's hard to know for a specific patient. We have a bunch of studies now that look at how long people have symptoms before they're diagnosed. There's a wide range.   [11:39] Some people get symptoms and get diagnosed right away. Others might have symptoms for 20 or 30 years that they ignore, or don't have access to healthcare, or the diagnosis is missed.   [11:51] What we see consistently is that people who may be diagnosed within a year or two may only have a 10 or 20% chance of having that stricture and scar tissue in the esophagus, whereas people who go 20 years, it might be 80% or more.   [12:06] It's not everybody who has EoE who might end up with that scar tissue, but certainly, it's suggested that it's a large majority.   [12:16] That's before diagnosis. We have data that shows that after diagnosis, if people go a long time without treatment or without being seen in care, they also have an increasing rate of developing strictures.    [12:29] In general, the idea is yes, you should treat EoE, because on average, people are going to develop scar tissue and more symptoms. For the patient in front of you with EoE but no symptoms, what are the chances it's going to get worse? You don't know.   [13:04] There are two caveats with that. The first is what we mean by symptoms. Kids may have vomiting and growth problems. Adults can eat carefully, avoiding foods that hang up in the esophagus, like breads and overcooked meats, sticky rice, and other foods.   [13:24] Adults can eat slowly, drink a lot of liquid, and not perceive they have symptoms. When someone tells Dr. Dellon they don't have symptoms, he will quiz them about that. He'll even ask about swallowing pills.    [13:40] Often, you can pick up symptoms that maybe the person didn't even realize they were having. In that case, that can give you some impetus to treat.   [13:48] If there really are no symptoms, Dr. Dellon thinks we're at a point where we don't really know what to do.   [13:54] Dr. Dellon just saw a patient who had a lot of eosinophils in their small bowel with absolutely no GI symptoms. He said, "I can't diagnose you with eosinophilic enteritis, but you may develop symptoms." People like that, he will monitor in the clinic.   [14:14] Dr. Dellon will discuss it with them each time they come back for a clinic visit.   [14:19] Holly is a speech pathologist, but also sees people for feeding and swallowing. The local gastroenterologist refers patients who choose not to treat their EoE to her. Holly teaches them things they should be looking out for.   [14:39] If your pills get stuck or if you're downing 18 ounces during a mealtime, maybe it's time to treat it. People don't see these coping mechanisms they use that are impacting their quality of life. They've normalized it.   [15:30] Dr. Dellon says, of these people who aren't treated, there's probably a subset who appropriately are being observed and don't have a medicine treatment or are on a diet elimination.   [15:43] There's also probably a subset who are inappropriately not on treatment. It especially can happen with students who were under good control with their pediatric provider, but moved away to college and didn't transfer to adult care.   [16:08] They ultimately come back with a lot of symptoms that have progressed over six to eight years.   [16:18] Ryan meets newly diagnosed adult patients at APFED's conferences, who say they have no symptoms, but chicken gets caught in their throat. They got diagnosed when they went to the ER with a food impaction.   [16:38] Ryan says you have to wonder at what point that starts to get reflected in patient charts. Are those cases documented where someone is untreated and now has EoE?   [16:49] Ryan asks in the study, "What is the target EGID Cohort and why was it selected to study EoE? What sort of patients were captured as part of that data set?"   [16:58] Dr. Jensen said they identified patients with the ICD-10 code for a diagnosis of EoE. Then they looked to see if there was evidence of symptoms or complications in relation to EoE. This was hard; some of these are relatively non-specific symptoms.   [17:23] These patients may have been seeking care and may have been experiencing some symptoms that may or may not have made it into the chart. That's one of the challenges with real-world data analyses.   [17:38] Dr. Jensen says they are using data that was collected for documenting clinical care and for billing for clinical care, not for research, so it comes with some caveats when doing research with this data.   [18:08] Research using electronic health records gives a real-world perspective on patients who are seeking care or have a diagnosis of EoE, as opposed to a study trying to enroll a patient population that potentially isn't representative of the breadth of individuals living with EoE.   [18:39] Dr. Dellon says another advantage of real-world data is the number of patients. The largest randomized controlled trials in EoE might have 400 patients, and they are incredibly expensive to do.   [18:52] A study of electronic health records (EHR) is reporting on the analysis of just under 1,000. The cohort, combined from three different centers, has more than 1,400 people, a more representative, larger population.    [19:16] Dr. Dellon says when you read the results, understand the limitations and strengths of a study of health records, to help contextualize the information.   [19:41] Dr. Dellon says it's always easier to recognize the typical presentations. Materials about EoE and studies he has done that led to medicine approvals have focused on trouble swallowing. That can be relatively easily measured.   [20:01] Patients often come to receive care with a food impaction, which can be impactful on life, and somewhat public, if in a restaurant or at work. Typical symptoms are also the ones that get you diagnosed and may be easier to treat.   [20:26] Dr. Dellon wonders if maybe people don't treat some of the atypical symptoms because it's not appreciated that they can be related to EoE.   [20:42] Holly was diagnosed as an adult. Ryan was diagnosed as a toddler. Holly asks what are some of the challenges people face in getting an EoE diagnosis.   [20:56] Dr. Jensen says symptoms can sometimes be fairly non-specific. There's some ongoing work by the CEGIR Consortium trying to understand what happens when patients come into the emergency department with a food bolus impaction.   [21:28] Dr. Jensen explains that we see there's quite a bit of variation in how that gets managed, and if they get a biopsy. You have to have a biopsy of the esophagus to get a diagnosis of EoE.   [21:45] If you think about the steps that need to happen to get a diagnosis of EoE, that can present barriers for some groups to ultimately get that diagnosis.   [21:56] There's also been some literature around a potential assumption about which patients are more likely to be at risk. Some of that is still ongoing. We know that EoE occurs more commonly in males in roughly a two-to-one ratio. Not exclusively in males, obviously, but a little more often in males.   [22:20] We don't know anything about other groups of patients that may be at higher risk. That's ongoing work that we're still trying to understand. That in itself can also be a barrier when there are assumptions about who is or isn't likely to have EoE.   [23:02] Dr. Dellon says that in adolescents and adults, the typical symptoms are trouble swallowing and food sticking, which have many causes besides EoE, some of which are more common.   [23:18] In that population, heartburn is common. Patients may report terrible reflux that, on questioning, sounds more like trouble swallowing than GERD. Sometimes, with EoE, you may have reflux that doesn't improve. Is it EoE, reflux, or both?   [24:05] Some people will have chest discomfort. There are some reports of worsening symptoms with exercise, which brings up cardiac questions that have to be ruled out first.   [24:19] Dr. Dellon mentions some more atypical symptoms. An adult having pain in the upper abdomen could have EoE. In children, the symptoms could be anything in the GI tract. Some women might have atypical symptoms with less trouble swallowing.   [24:58] Some racial minorities may have those kinds of symptoms, as well. If you're not thinking of the condition, it's hard to make the diagnosis.   [25:08] Dr. Jensen notes that there are different cultural norms around expressing symptoms and dietary patterns, which may make it difficult to parse out a diagnosis.   [25:27] Ryan cites a past episode where access to a GI specialist played a role in diagnosing patients with EoE. Do white males have more EoE, or are their concerns just listened to more seriously?   [25:57] Ryan's parents were told when he was two that he was throwing up for attention. He believes that these days, he'd have a much easier time convincing a doctor to listen to him. From speaking to physicians, Ryan believes access is a wide issue in the field.   [26:23] Dr. Dellon tells of working with researchers at Mayo in Arizona and the Children's Hospital of Phoenix. They have a large population of Hispanic children with EoE, much larger than has been reported elsewhere. They're working on characterizing that.   [26:49] Dr. Dellon describes an experience with a visiting trainee from Mexico City, where there was not a lot of EoE reported. The trainee went back and looked at the biopsies there, and it turned out they were not performing biopsies on patients with dysphagia in Mexico City.   [27:13] When he looked at the patients who ended up getting biopsies, they found EoE in 10% of patients. That's similar to what's reported out of centers in the developed world. As people are thinking about it more, we will see more detection of it.   [27:30] Dr. Dellon believes those kinds of papers will be out in the next couple of months, to a year.   [27:36] Holly has had licensure in Arizona for about 11 years. She has had nine referrals recently of children with EoE from Arizona. Normally, it's been one or two that she met at a conference.   [28:00] Ryan asks about the research on patients not having their EoE treated pharmacologically. Some treat it with food avoidance and dietary therapy. Ryan notes that he can't have applesauce, as it is a trigger for his EoE.   [28:54] Dr. Jensen says that's one of the challenges in using the EHR data. That kind of information is only available to the researchers through free text. That's a limitation of the study, assessing the use of dietary elimination approaches.   [29:11] Holly says some of her patients have things listed as allergies that are food sensitivities. Ryan says it's helpful for the patients to have their food sensitivities listed along with their food allergies, but it makes records more difficult to parse for research.   [30:14] Dr. Dellon says they identify EoE by billing code, but the codes are not always used accurately. Natural Language Processing can train a computer system to find important phrases. Their collaborators working on the real-world data are using it.   [30:59] Dr. Dellon hopes that this will be a future direction for this research to find anything in the text related to diet elimination.   [31:32] Dr. Jensen says that older patients were less likely to seek medication therapy. She says it's probably for a couple of reasons. First, older patients may have been living with the disease for a long time and have had compensatory mechanisms in place.   [32:03] The other reason may be senescence or burnout of the disease, long-term. Patients may be less symptomatic as they get older. That's a question that remains to be answered for EoE. It has been seen in some other disease processes.   [32:32] Dr. Dellon says there's not much data specifically looking at EoE in the older population. Dr. Dellon did work years ago with another doctor, and they found that older patients had a better response to some treatments, particularly topical steroids.   [32:54] It wasn't clear whether it was a milder aspect of the disease, easier to treat, or because they were older and more responsible, taking their medicines as prescribed, and having a better response rate. It's the flip side of work in the pediatric population.   [33:16] There is an increasingly aging population with EoE. Young EoE patients will someday be over 65. Dr. Dellon hopes there will be a cure by that point, but it's an expanding population now.   [33:38] Dr. Jensen says only a few sites are contributing data, so they hope to add additional sites to the study. For some of the less common outcomes, they need a pretty large patient sample to ask some of those kinds of questions.   [33:55] They will continue to follow up on some of the work that this abstract touched on and try to understand some of these issues more deeply.   [34:06] Dr. Dellon mentions other work within the cohort. Using Natural Language Processing, they are looking at characterizing endoscopy information and reporting it without a manual review of reports and codes. You can't get that from billing data.   [34:29] Similarly, they are trying to classify patient severity by the Index of Severity with EoE, and layer that on looking at treatments and outcomes based on disease severity. Those are a couple of other directions where this cohort is going.   [34:43] Holly mentions that this is one of many research projects Dr. Jensen and Dr. Dellon have collaborated on together. They also collaborate through EGID Partners. Holly asks them to share a little bit about that.   [34:53] Dr. Jensen says EGID Partners is an online registry where individuals, caregivers, and parents of children affected with EGIDs can join.   [35:07] EGID Partners also needs people who don't live with an EGID to join, as controls. That gives the ability to compare those who are experiencing an EGID relative to those who aren't.   [35:22] When you join EGID Partners, they provide you with a set of questionnaires to complete. Periodically, they push out a few more questionnaires.   [35:33] EGID Partners has provided some really great information about patient experience and answered questions that patients want to know about, like joint pain and symptoms outside the GI tract.   [36:04] To date, there are close to 900 participants in the registry from all over the world. As it continues to grow, it will give the ability to look at the patient experience in different geographical areas.   [36:26] Dr. Dellon says we try to have it be interactive, because it is a collaboration with patients. The Steering Committee works with APFED and other patient advocacy groups from around the world.    [36:41] The EGID Partners website shows general patient locations anonymously. It shows the breakdown of adults with the condition and caregivers of children with the condition, the symptom distribution, and the treatment distribution.   [37:03] As papers get published and abstracts are presented, EGID Partners puts them on the website. Once someone joins, they can suggest a research idea. Many of the studies they have done have come from patient suggestions.   [37:20] If there's an interesting idea for a survey, EGID Partners can push out a survey to everybody in the group and answer questions relatively quickly.   [37:57] Dr. Dellon says a paper came out recently about telehealth. EoE care, in particular, is a good model for telehealth because it can expand access for patients who don't have providers in their area.   [38:22] EoE is a condition where care involves a lot of discussion but not a lot of need for physical exams and direct contact, so telehealth can make things very efficient.    [38:52] EGID Partners surveyed patients about telehealth. They thought it was efficient and saved time, and they had the same kind of interactions as in person. In general, in-state insurance covered it. Patients were happy to do those kinds of visits again.   [39:27] Holly says Dr. Furuta, herself, and others were published in the Gastroenterology journal in 2019 about starting to do telehealth because patients coming to the Children's Hospital of Colorado from out of state had no local access to feeding therapy.   [39:50] Holly went to the board, and they allowed her to get licensure in different states. She started with some of the most impacted patients in Texas and Florida in 2011 and 2012. They collected data. They published in 2019 about telehealth's positive impact.   [40:13] When 2020 rolled around, Holly had trained a bunch of people on how to do feeding therapy via telehealth. You have to do all kinds of things, like make yourself disappear, to keep the kids engaged and in their chairs!   [40:25] Now it is Holly's primary practice. She has licenses in nine states. She sees people all over the country. With her diagnosis, her physicians at Mass General have telehealth licensure in Maine. She gets to do telehealth with them instead of driving two hours.   [40:53] Dr. Jensen tells of two of the things they hope to do at EGID Partners. One is trying to understand more about reproductive health for patients with an EGID diagnosis. Only a few studies have looked at this question, and with very small samples.   [41:15] As more people register for EGID Partners, Dr. Jensen is hoping to be able to ask some questions related to reproductive health outcomes.   [41:27] The second goal is a survey suggested by the Student Advisory Committee, asking questions related to the burden of disease specific to the teen population.   [41:48] This diagnosis can hit that population particularly hard, at a time when they are trying to build and sustain friendships and are transitioning to adult care and moving away from home. This patient population has a unique perspective we wanted to hear.   [42:11] Dr. Jensen and Dr. Dellon work on all kinds of other projects, too.   [42:22] Dr. Dellon says they have done a lot of work on the early-life factors that may predispose to EoE. They are working on a large epidemiologic study to get some insight into early-life factors, including factors that can be measured in baby teeth.   [42:42] That's outside of EGID Partners. It's been ongoing, and they're getting close, maybe over the next couple of years, to having some results.   [43:03] Ryan says all of those projects sound so interesting. We need to have you guys back to dive into those results when you have something finalized.   [43:15] For our listeners who want to learn more about eosinophilic disorders, we encourage you to visit apfed.org and check out the links in the show notes below.   [43:22] If you're looking to find specialists who treat eosinophilic disorders, we encourage you to use APFED's Specialist Finder at apfed.org/specialist.   [43:31] If you'd like to connect with others impacted by eosinophilic diseases, please join APFED's online community on the Inspire Network at apfed.org/connections.   [43:41] Ryan thanks Dr. Dellon and Dr. Jensen for joining us today. This was a fantastic conversation. Holly also thanks APFED's Education Partners GSK, Sanofi, Regeneron, and Takeda for supporting this episode.   Mentioned in This Episode: Evan S. Dellon, MD, MPH, Academic Gastroenterologist, University of North Carolina School of Medicine   Elizabeth T. Jensen, MPH, PhD, Epidemiologist, Wake Forest University School of Medicine, University of North Carolina at Chapel Hill   Predictors of Patients Receiving No Medication for Treatment of Eosinophilic Esophagitis in the United States: Data from the TARGET-EGIDS Cohort   Episode 15: Access to Specialty Care for Eosinophilic Esophagitis (EoE)   APFED on YouTube, Twitter, Facebook, Pinterest, Instagram Real Talk: Eosinophilic Diseases Podcast apfed.org/specialist apfed.org/connections apfed.org/research/clinical-trials   Education Partners: This episode of APFED's podcast is brought to you thanks to the support of GSK, Sanofi, Regeneron, and Takeda.   Tweetables:   "I've been working on eosinophilic gastrointestinal diseases for about 15 years. I started some of the early work around understanding possible risk factors for the development of disease. I've gone on to support lots of other research projects." — Elizabeth T. Jensen, MPH, PhD   "You can think of EoE as asthma of the esophagus or eczema of the esophagus, although in general, people don't grow out of EoE, like they might grow out of eczema or asthma. When people have it, it really is a long-term condition." — Evan S. Dellon, MD, MPH   "There are two general approaches to treating the underlying condition, … using medicines and/or eliminating foods from the diet that we think may trigger EoE. I should say, for a lot of people, EoE is a food-triggered allergic condition." — Evan S. Dellon, MD, MPH   "I didn't find it that surprising [that there are patients who had no treatment]. Some patients are relatively asymptomatic, and others are not interested in pursuing medications initially or are … still exploring dietary treatment options." — Elizabeth T. Jensen, MPH, PhD   "We have a bunch of studies now that look at how long people have symptoms before they're diagnosed. There's a wide range. Some people get symptoms and are diagnosed right away. Other people might have symptoms for 20 or 30 years." — Evan S. Dellon, MD, MPH   "EGID Partners is an online registry where individuals, caregivers, and parents of children affected with EGIDs can join. EGID Partners also needs people who don't live with an EGID to join, as controls." — Elizabeth T. Jensen, MPH, PhD

Worship with us live online at ExploreGracePoint.com/church-onlineGracePoint Church2351 Rice Creek RdNew Brighton, MN 55112

Covid vaccines boosted the immune response in people being treated for cancer and improved their survival, a recent study concludes. mRNA expert Jeff Coller at Johns Hopkins says as more evidence mounts establishing the benefits of mRNA vaccines, we need … Many vaccines are intended to reduce disease severity, Elizabeth Tracey reports Read More »

Welcome to GamePlan with the Sports Docs. On each of these mini episodes, we chat about a new article or new surgical technique in the field of sports medicine. We'll give you our quick take on the most recent data and how this data will be impacting our practice.Today, we're talking about hamstring injuries in the NFL. And if your fantasy team is anything like my fantasy team, it currently looks like an infirmary. So, you'll probably want to listen in to this episode.Now, we've covered hamstring injuries in the NFL before.  Last year we did an entire Game Plan episode dedicated to this topic.  That is episode #52 if you want to check it out. Today, we are actually reviewing a new study just published this month in AJSM that focused on how player characteristics, injury severity and imaging findings can impact the amount of time missed as well as risk of recurrent injury. The article is titled “Correlation of Player and Imaging Characteristics with Severity and Missed Time in the National Football League Professional Athletes with Hamstring Strain Injury.” Molly Day, Scott Rodeo and team at HSS published this retrospective cross-sectional study that aimed to identify certain player characteristics, clinical examination findings and MRI  results that were associated with injury severity and missed playing time. As always, links to all of the papers that we discuss on this show can be found on our podcast website – www.thesportsdocspod.com

What will this fall and winter season bring? Will it be ducky? Or are we in another lull until January, find out today in the first of two Long-term Weather Severity Forecasts! DrMike digs deep into data that predicts or winter weather, that and your weekly duck migration forecast.

How dangerous and quite simply, how bad is sin…how severe it is, but how thankful we are for God’s provisions to address sin through Jesus.

This week, Pastor Abraham leads us back into our series on the minor prophets with Nahum. Take a deeper look with us at this short, but often neglected book.

How dangerous and quite simply, how bad is sin…how severe it is, but how thankful we are for God's provisions to address sin through Jesus. To support this ministry financially, visit: https://www.oneplace.com/donate/1561/29

Aquí San Pablo está asegurando nos de que en el futuro, los judíos en gran números van a regresar a la fe verdadera. Esto aun no ha pasado, pero cuando pasa, será una ayuda tremenda para la causa de Cristo.

The conversation delves into the concept of deterrence in crime prevention, emphasizing that the likelihood of being caught and punished is a more significant factor than the severity of the punishment itself. It highlights that longer sentences do not effectively deter crime if offenders believe they can evade capture.In the intricate world of criminal law, understanding the principles of punishment and sentencing is crucial. This post delves into the philosophical debates and practical applications that shape the justice system today. From historical shifts to modern challenges, we explore the core tensions and evolving standards that define this field.The Evolution of Punishment: Historically, punishment has transformed from physical and public sanctions to more regulated and humane approaches. This shift reflects changing societal values and the evolving standards of decency that courts use today. The question remains: why do we punish at all? This leads us to the two major philosophies in sentencing—utilitarianism and retribution.Retribution vs. Utilitarianism: Retribution focuses on the past act, advocating for punishment as a moral necessity. In contrast, utilitarianism looks forward, weighing the societal benefits against the costs of punishment. This philosophical divide influences every sentencing decision, from deterrence to rehabilitation.The Role of Deterrence: Deterrence is a key goal in utilitarian sentencing, aiming to prevent future crimes. However, the effectiveness of deterrence is debated, with studies showing that the certainty of punishment is more impactful than its severity. This insight challenges the traditional reliance on harsh sentences as a deterrent.Constitutional Limits and the Eighth Amendment: The Eighth Amendment serves as a constitutional check against excessive punishment. Its interpretation has led to significant legal precedents, particularly in capital cases. The amendment's role in non-capital cases, however, remains a topic of debate, with courts often deferring to legislative policy choices.The landscape of punishment and sentencing is complex, shaped by historical, philosophical, and legal factors. As we navigate these challenges, the balance between retribution and utilitarian goals continues to evolve. Understanding these dynamics is essential for anyone studying or practicing criminal law.Subscribe Now: Stay informed on the latest developments in criminal law by subscribing.TakeawaysThe deterrent effect of certainty is much stronger than severity.Longer sentences are ineffective if offenders think they can escape punishment.Severity deters only when the certainty of being caught is high.Offenders' calculations are influenced more by perceived chances of getting caught than by potential penalties.Understanding offender behavior is crucial for effective crime prevention strategies.Policies should focus on increasing the likelihood of apprehension rather than just increasing penalties.The relationship between certainty and severity is complex and requires careful consideration.Effective deterrence strategies must address the mindset of potential offenders.Crime prevention efforts should prioritize certainty over severity in their approaches.Research consistently supports the importance of certainty in deterrence.deterrence, crime prevention, certainty, punishment, severity, offender behavior

This podcast is published open access in Dermatology and Therapy and is fully citeable. You can access the original published podcast article through the Dermatology and Therapy website and by using this link:https://link.springer.com/article/10.1007/s13555-025-01551-7. All conflicts of interest can be found online. This podcast is intended for medical professionals. Open Access This podcast is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The material in this podcast is included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

In this episode of Fire Ecology Chats, Fire Ecology editor Bob Keane speaks with Elijah Orland about using thermal imagery to better understand what leads to burn severity and how quickly we can get that information to others.Full journal article can be found at https://fireecology.springeropen.com/articles/10.1186/s42408-025-00407-x

Send us comments, suggestions and ideas here! In this week's show we explore the first thirteen lines from Liber ARARITA and explore each one's corresponding sephirah on the Tree of Life, discussing its corresponding planetary god from the Greek and Roman tradition along with a profile of the angelic archangel who rules over each station. This chapter corresponds to the “Good” side of the Tree of Life and explains it in fairly classical, straight-forward terms. On the free side of the show we make it all the way from Kether to Gevurah but discover that we've run out of time and resume our discussion of Tiphareth through Malkuth during the paid section of the show which includes a rousing discussion about Jacob and his battle with the angel we suspect to be Kamael. Tune in next week to hear about how the Tree of Life from this week matches up with the Tree of Death and its corresponding orders of demons. Thank you and enjoy the show!for more great content by Tim Hacker make sure to check out CryticChronicles.comOn this week's show we discuss:Surah 112The Ain Soph AuirKether, The CrownMetatronThe Vault of HeavenThe Flaming Star and the Sixfold StarBinah, UnderstandingZadkiel, Archangel of Mercy Chesed, MercyDaddy JupiterGevurah, Severity vs. Pachad, FearOn the extended side of the show available at www.patreon.com/TheWholeRabbit we finish discussing the tree and talk about:Tiphareth, BeautyThe Beloved Gods of the SunRaphael, Physician of GodVenus, Goddess of EXTREME LOVEJacob's Thigh and NetzachHaniel, the Romantic Angel. Yesod, The FoundationGabriel, God's Strength! Michael, God's BonkerSandalphon, Metatron's TwinThis episode was prepared by Luke Madrid and Heka Astra with angel commentaries included by Tim Hacker, Blue sections read by Mari Sama.Where to find The Whole Rabbit:Spotify: https://open.spotify.com/show/0AnJZhmPzaby04afmEWOAVInstagram: https://www.instagram.com/the_whole_rabbitTwitter: https://twitter.com/1WholeRabbitOrder Stickers: https://www.stickermule.com/thewholerabbitOther Merchandise: https://thewholerabbit.myspreadshop.com/Music By Spirit Travel Plaza:https://open.spotify.com/artist/30dW3WB1sYofnow7y3V0YoSources:Liber ARARITA / IAO 131https://iao131.com/commentaries/liber-dcccxiii-vel-ararita-sub-figura-dlxx/Book of Thoth:https://dn710008.ca.archive.org/0/items/out-of-print-and-rare-books-collection/BookOfThoth.pdfAbrahadabra:http://www.thelemapedia.org/index.php/ABRAHADABRABook of the Law:https://sacred-texts.com/oto/engccxx.htmTHE GEMATRIA NOTEBOOKS OF PAUL FOSTER CASEDion Fortune, Mystical KabbalahVision and the Voice:Support the show

In hour 1, the WIP Midday Show are discussing the AJ Brown post game comments and whole situation in more details. Particularly Hugh who claims he knows people close to the Eagles that have sad the situation is "bad, bad"

High-severity wildfires that burn communities are obviously bad. But what about high-severity fire that burns in the backcountry? Guest Dr. Dick Hutto, Emeritus Professor of biology and wildlife biology at the University of Montana and author of the recently published book A Beautifully Burned Forest: Learning to Celebrate Severe Forest Fire, makes the case that high-severity fire has been unfairly demonized and this fire forms an important and transitory habitat type. Rethinking high-severity fire has policy consequences. Do we invest as heavily in fire risk reduction for wildlands or is funding better spent in and near communities? Do we invest as heavily in fire suppression where fires are burning far from human habitations? And what do we do after fires burn—do we log and replant or leave it be? Listen to hear Dr. Hutto's prescriptions.Want to learn more? Check out Dr. Hutto's website on fire ecology. Support the show

In this episode of Fire Ecology Chats, Fire Ecology editor Bob Keane speaks with Astrid Sanna, Alina Cansler, and Craig Bienz about evaluating fuel treatments of fire suppression operations through the 2021 Bootleg Fire of South-Central Oregon.Full journal article can be found at https://fireecology.springeropen.com/articles/10.1186/s42408-025-00387-y

நரகமும் அதன் கடுமையும் [Surah Al-Kahf: 51 to 53] மவ்லவி அலி அக்பர் உமரி | Ali Akbar Umari 14-09-2025 Taqwa Masjid, Trichy

நரகமும் அதன் கடுமையும் [Surah Al-Kahf: 51 to 53] - கேள்வி பதில் அமர்வுமவ்லவி அலி அக்பர் உமரி | Ali Akbar Umari14-09-2025Taqwa Masjid, Trichy

Severity of common cold symptoms fell 41% in the fittest and 31% in the most active.https://bjsm.bmj.com/content/45/12/987.abstractFlu shots in children: 5× higher risk of noninfluenza respiratory infections (incl. coronaviruses).https://pubmed.ncbi.nlm.nih.gov/22423139/Glyphosate damages gut health.https://www.mdpi.com/1099-4300/15/4/1416Adults sleeping ≤6 h/night were ~4× more likely to develop a cold after rhinovirus exposure; similar with ≤7 h + low sleep efficiency.https://pmc.ncbi.nlm.nih.gov/articles/PMC4531403/Vitamin D deficiency was common in COVID patients—41.9% overall, 80% in severe cases.https://pubmed.ncbi.nlm.nih.gov/33048028/Sea lion study:https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2020.602565/fullNFL player's story:https://bleacherreport.com/articles/1859740-random-things-most-nfl-fans-never-knew-football-players-almost-never-get-sickCowling 2012: Flu shots in children increased risk of noninfluenza infections 5×.https://pubmed.ncbi.nlm.nih.gov/22423139/Wolff study: Vaccinated servicemen had higher odds of coronavirus (+36%), metapneumovirus (+51%), and other noninfluenza viruses (+15%).https://www.sciencedirect.com/science/article/pii/S0264410X19313647Vaccinated kids ≤4 yrs: 4.8× higher hazard of noninfluenza infection (CI 2.88–7.99). Ages 5–17: 1.61× higher hazard (CI 0.98–2.66).https://pubmed.ncbi.nlm.nih.gov/29525279/Chris Kresser (2021): Vitamin D deficiency raised SARS-CoV-2 infection risk by 80%. Deficient patients had 1.77× higher infection risk, 2.57× more severe, 2.35× higher mortality.https://vimeo.com/530879066/e9b314a0beTom Jefferson review of 259 BMJ studies: Flu vaccines had little effect on outcomes like absences, days lost, illness, or death.https://pmc.ncbi.nlm.nih.gov/articles/PMC1626345/Pesticide research (http://ndl.ethernet.edu.et/bitstream/123456789/54884/1/Jonathan%20J.%20Li_2008.pdf#page=399):• Women with reproductive cancers had 4–6× higher pesticide levels (8.7–10.9 mg/L vs 1.9 mg/L).• Living ≤1 mile from a golf course → 126% higher Parkinson's risk; risk drops 13% per mile after 3 mi.• Shared water with golf course → nearly 2× PD risk.• Vulnerable groundwater regions → 82% higher PD risk.“These chemicals can be carcinogenic, mutagenic, teratogenic, and estrogenic (disrupting hormones).”If you need other studies, ask AI or email shortlifeadvice@gmail.com

When we are experiencing a lot of stress or recovering from trauma or addiction, we can find ourselves living in a fight-flight-freeze state, where we feel either disconnected from or unsafe in our bodies. This practice is designed to gently cultivate a sense of safety and then create a kinesthetic anchor (rooted in awareness of how our body is moving) to start building a felt sense of security that your body can remember. Emily Jane is a mindfulness teacher, certified Embodied Processing (EP) practitioner, and recovery coach with a background in social work. She's been in recovery for over eight years, following two decades of active addiction, and her lived experience now fuels her passion for helping others heal. Emily is also the author of Beyond Addiction: A Mindful Guide to Recovery, where she shares her trauma-informed, compassionate approach to healing. Her work integrates mindfulness, coaching, trauma therapy, and somatic tools to help people reconnect with their bodies and find safety, peace, and empowerment on their recovery journey. The transcription of this guided meditation will be online at Mindful.org next week.  Stay curious, stay inspired. Join our community by signing up for our free newsletter:  mindful.org/signup Show Notes Find more from Emily Jane here. You can order your copy of Beyond Addiction here.  Go Deeper If you want to learn more about embodied practice and how mindfulness can aid in addiction recovery, check out these articles: Make It Personal: How Mindfulness Can Support Highly Stressed People A Simple Inquiry Practice to Unwind from Stress Could Mindfulness Decrease the Severity of Opioid Cravings?  Constant Craving  For more practice, here's another meditation to try: HALT Practice to Tune In to What Your Body Needs  And more from Mindful here: More episodes of 12 Minute Meditation Let us know what you thought of this episode of 12 Minute Meditation by leaving a review or by emailing yourwords@mindful.org.

In this episode of Fire Ecology Chats, Fire Ecology editor Bob Keane speaks with Jonathan Batchelor about exploring how drone-based photogrammetrictry could provide a more complete picture of fire impacts on the forest floor.Full journal article can be found at https://fireecology.springeropen.com/articles/10.1186/s42408-025-00375-2

Bruce and Gaydos recap the biggest dust storm since 2011!

Association between housing status and mental health and substance use severity among individuals with opioid use disorder and co-occurring depression and/or PTSD  BMC Primary Care  This is a cross-sectional analysis of associations between housing status and mental health and substance use severity among primary care patients with co-occurring disorders. The study is a sub-analysis using data from the Collaboration Leading to Addiction Treatment and Recovery from other Stresses randomized controlled trial, which tested the Collaborative Care Model for primary care patients with OUD and co-occurring depression and/or PTSD. Of 797 patients in the study, 13% were currently unhoused, 24% were unstably housed, and 63% were stably housed. Those who were unhoused were on average younger and had not used prescribed MOUD in the past 30 days. The analysis found that being unhoused or unstably housed was significantly associated with higher PTSD symptom severity, depression symptom severity, opioid use severity, and opioid overdose risk behaviors compared to those who were stably housed.   Read this issue of the ASAM Weekly Subscribe to the ASAM Weekly Visit ASAM

Federal agencies scrambled over the past several days to address a severe vulnerability in widely used Microsoft collaboration products. The software bug in Microsoft Exchange could be used by hackers to take over much of an organization's network, federal news networks. Justin Doubleday is Here with more on the latest cyber news. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In part two of this two-part series, Dr. Stacey Clardy and Casey R. Vanderlip discuss the changes that neurologists should implement in their clinics based on the findings from this study regarding APOE genotype.  Show reference: https://www.neurology.org/doi/10.1212/WNL.0000000000213853  

In part one of this two part series, Dr. Stacey Clardy and Casey R. Vanderlip discuss what neurologists need to know about how APOE4 and amyloid interact to impact cognitive function.  Show reference:  https://www.neurology.org/doi/10.1212/WNL.0000000000213853 

Dr. Stacey Clardy talks with Casey R. Vanderlip about whether the accelerated decline in episodic memory among APOE4 carriers is due to increased Aβ deposition or heightened susceptibility to Aβ-related effects.  Read the related article in Neurology®.  Disclosures can be found at Neurology.org. 

Bro. Chris Seagle preaching live from Still Water Baptist Church on 7.27.25 am

Did MetroHealth's $1 billion expansion put the hospital system into financial distress? Learn more about your ad choices. Visit megaphone.fm/adchoices

Many look upon God like an old faithful grandfather. But the Bible speaks of His goodness AND His severity. We return to the book of Romans for this study and to choose the God and Father we should serve.

Are patients from lower-income households more likely to present with severe diabetic retinopathy (DR)? Ben Young, MD, moderates a discussion with Phoebe Mellen, MD, and Jordan Deaner, MD, about a new retrospective cohort study from the Duke Eye Center than examines differences in DR severity at presentation between patients from the lowest- and highest-income ZIP codes, explores how income-based barriers to care may impact disease progression, and discusses how this data might affect clinical care, screening strategies, and public health priorities.

Sermon from Exodus 4 in St. Charles, IL

In this episode of Command Control Power, hosts welcome Adam Burg from CALSO Technologies to share his harrowing experience with the Eaton Fire in Altadena, California. Adam recounts the events leading up to the evacuation of his family, the destruction of their home, and their subsequent journey to recovery. He highlights the overwhelming support from the community, the importance of preparedness, and offers advice for ensuring business continuity in the face of natural disasters. The episode provides a detailed and emotional account of resilience and the power of community. https://www.gofundme.com/f/support-the-burg-family-after-the-eaton-fire-in-altadena   00:00 Introduction and Welcome 00:23 Adam's Tragic Experience in LA 01:22 Evacuation and Immediate Aftermath 03:10 Community Support and Personal Reflections 04:14 The Fire's Impact on Daily Life 05:07 Realization of the Fire's Severity 06:32 Evacuation Orders and Family Preparations 08:25 The Night of the Evacuation 10:27 Returning to the Devastation 18:58 Cleanup and Recovery Efforts 30:20 Architectural Heritage and Rebuilding 31:45 Life at the Hotel: Initial Experiences 32:56 Community and Support Among Families 34:26 Interactions with Firefighters 35:36 Challenges of Hotel Living 36:43 Emotional Impact on the Family 38:01 Reflections on Community and Support 39:28 Environmental Refugees and Climate Change 41:34 Insurance and Preparedness 47:10 Rebuilding and Client Support 55:00 Lessons Learned and Final Thoughts Meet the community trying to save Altadena's history after the L.A. fires

In the world of workers compensation, loss runs affect a business's risk evaluation. Underwriters look carefully at a company's claim history. This process gives them an understanding of how frequently claims are happening, how severe they are, and if a business is putting effort into reducing workplace risk. Learn the differing impact of claim frequency versus claim severity on a business' s risk evaluation with Becky Duello, Senior Underwriter at MEM.

Welcome to episode 183 of Growers Daily! We cover: garlic rust and what to do about it, how to tell if your soil is healthy, and it's feedback friday! We are a Non-Profit! 

In this episode of 'Cybersecurity Today,' host Jim Love discusses urgent cybersecurity threats and concerns. Cisco has issued emergency patches for two maximum severity vulnerabilities in its Identity Services Engine (ISE) that could allow complete network takeover; organizations are urged to update immediately. A popular WordPress theme, Motors, has a critical vulnerability leading to mass exploitation and unauthorized admin account creation. A new ransomware group, Dire Wolf, has emerged, targeting manufacturing and technology sectors with sophisticated double extortion tactics. Lastly, an Accenture report reveals a dangerous gap between executive confidence and actual AI security preparedness, suggesting most major companies are not ready to handle AI-driven threats. The episode emphasizes the urgent need for immediate action and heightened awareness in the cybersecurity landscape. 00:00 Introduction and Headlines 00:26 Cisco's Critical Security Flaws 03:06 WordPress Theme Vulnerability Exploitation 05:57 Dire Wolf Ransomware Group Emerges 08:27 Accenture Report on AI Security Overconfidence 11:00 Conclusion and Upcoming Schedule

In this episode, Kimberly and Alex discuss his extensive background in working with children on the Autism Spectrum Disorder (ASD). He spent much of those years taking a non-traditional approach from just behavioral to prioritizing fun and community. This work led him to keenly understanding the importance of local agriculture, nutrition, and the gut-brain connection, and eventually he began working as an animal butcher and supporting his wife's work, The Wild Nutritionist. Aspects of their discussion are connected through the thread of the importance of holistic care for ASD individuals as well as local farming, nutrition, and the gut-brain connection.   Bio Alex Johnson is a father, butcher, former autism specialist, husband of Kate Pope, The Wild Nutritionist, and long-term friend of Kimberly's. His background in theater studies, and then psychology, led him to working with children on the Autism Spectrum Disorder for over a decade. Understanding the needs of this population then helped him transition to regenerative agriculture and animal butchery.    What He Shares: –Working with children on the Autism Spectrum Disorder –How and why ASD has changed in recent years –Harms and limitations of diagnoses and labels –Transitioning to regenerative agriculture and butchery –Prioritizing community through local farming   What You'll Hear: –How Alex began working with kids –Studied theater and psychology –Role play and autism in 2010 –How insurance changed autism  –In home and in community teaching to kids with ASD –Bringing families together with potlucks –DSM-5 refining definition of ASD –Disproportionately diagnosed in boys versus girls –Severity ratings (1, 2, 3) of ASD –Issues with self-diagnoses –Performative vulnerability –Challenges in diagnosing ASD –Social, Communication, and Behavior  –Familial approaches to ASD and community –Neurodivergence and ASD labels –Limitations of checklists of diagnoses –Gut issues and ASD –Behavioral versus holistic and community care –Regenerative agriculture, nutrition, and ASD –Transitioning to animal butchery –Small-scale, mobile harvest operation  –Mobile Harvest Truck –Art of animal butchery and carrying traditions –Politics and farming –Community care in farming and rural areas –Nutritional needs for families –Getting kids involved in family nutrition –Importance of local farmers markets –Talking to local farmers –Buying seasonal produce –Harms of individual priorities versus community –Returning to community care   Resources Website: https://regenerativecookingschool.com/ IG: @wildnutrionist  

A big, deep dive into CTA and fractional flow reserve CT, and a sobering report on the new EVOQUE valve are discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback and Correction CRAAFT HF https://clinicaltrials.gov/study/NCT06505798 II Imaging and Behavior Change SCOT HEART 1 https://www.nejm.org/doi/full/10.1056/NEJMoa1805971 Five Reasons I Don't Believe an Imaging Test Improves Outcomes https://www.medscape.com/viewarticle/901204 SCOT HEART 2 https://www.jacc.org/doi/10.1016/j.jcmg.2024.05.016 III. More on Imaging and CT FFR Symptoms Don't Always Indicate the Severity of Coronary Artery Disease https://www.medscape.com/viewarticle/symptoms-dont-always-indicate-severity-coronary-artery-2025a1000ge6 ADVANCE Registry Protocol https://www.journalofcardiovascularct.com/article/S1934-5925(16)30288-X/abstract Research Letter JACC CV Imaging  https://doi.org/10.1016/j.jcmg.2025.05.002 ADVANCE Registry Paper 2018 https://doi.org/10.1093/eurheartj/ehy530 Cook et al JAMA Card https://jamanetwork.com/journals/jamacardiology/fullarticle/2629072 Low diagnostic yield Patel paper NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa0907272 Venk Murthy thread https://x.com/venkmurthy/status/1033379922679660544 IV EVOQUE Real World Data JACC has published a sobering research letter on the Transcatheter Tricuspid Valve Replacement called EVOQUE valve. Lupu et al JACC IV https://doi.org/10.1016/j.jcin.2025.03.019 TRISCEND II https://www.nejm.org/doi/full/10.1056/NEJMoa2401918 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Are you ready to discover how the keto diet can transform not just your body but also your mind? In this eye-opening episode of the Savage Perspective Podcast, host Robert Sikes and guest John Palomo dive deep into the incredible healing powers of the ketogenic diet. They explore its role in recovery from brain injuries, improvements in mental clarity, and overall well-being, making this a must-watch for anyone looking to enhance both their physical and mental health.Join Robert in his FREE Bodybuilding Masterclass to learn how to achieve your fitness goals while maximizing the benefits of nutrition and training tailored just for you: https://www.ketobodybuilding.com/registration-2In this episode, you'll hear firsthand accounts of recovery from traumatic brain injuries and the power of dietary changes that led to extraordinary transformations. With personal stories of challenges faced and overcome, this discussion highlights the strength found in resilience and the importance of making informed health decisions.Learn how implementing the keto diet not only boosts energy but also improves mental clarity while fostering strong family bonds through a shared commitment to healthy habits. Don't miss this inspiring episode and the chance to reshape your understanding of health and recovery on the Savage Perspective Podcast. Tune in now.Register For My FREE Masterclass: https://www.ketobodybuilding.com/registration-2Get Keto Brick: https://www.ketobrick.com/Subscribe to the podcast: https://open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQChapters:0:00 How Keto Diet Helped Brain Injury Recovery2:02 Realizing the Severity of Concussions5:50 A Scary Bike Accident Story7:45 Overcoming a Traumatic Brain Injury11:47 Shifting to Keto After an Injury13:43 Discovering Healing Supplements17:18 Transformative Health Realization19:08 Benefits of Keto for Mental Health22:57 Keto's Energy Boost Beyond Weight Loss24:39 Dietary Changes to Reverse Chronic Issues28:11 Family Dynamics and Keto Challenges29:53 Strengthening Family Bonds with Low-Carb33:05 Teaching Healthy Eating to Kids34:46 Embracing Extremes for Personal Growth38:02 Mental Resilience in Endurance Events39:38 Redefining Limits Through Physical Challenges43:09 Improving Perspective on Challenges44:51 Endurance Shapes Mental Strength47:58 Balancing Protein for Keto Success49:47 Optimizing Mental and Physical Performance53:40 Adjusting Carbs for Keto Adaptability55:21 Quality Carbs for Better Mood and Health58:45 Inspiring Kids Through Physical Activity1:00:25 Family Involvement in Fitness Goals1:03:44 Balancing Fitness with Personal Commitments1:05:07 Prioritizing Family Time Over Social Media