Podcasts about hentschel

On this episode, Host Tom Loarie talks with American Tours International (ATI) Founder and CEO, Noel Irwin Hentschel, this week's guest mentor. Hentschel will address pressing issues facing the travel industry today and will discuss the leadership lessons learned under her mentor, “The Greatest CEO of All Time.” ATI is the nation's largest full-service tour operator, partnering with more than 30,000 suppliers across all 50 states to serve clients in more than 70 international markets. Learn about the comeback of the travel industry and the world's greatest CEO of all time. Find Show Notes here. Listen the to radio podcast below. And don't forget to Sign Up for all the FREE radio podcasts here.

Really? Decadron can worsen mortality in GBMs? This week Karl and I go over the evidence showing that steroids might not be the best thing for GBM patients. Specifically, it looks like dexamethasone might interfere with the effectiveness of chemo and radiation, leading to worse outcomes. Literature Referenced: Opinion paper that summarizes the argument against using Decadron in GBM patients: Wong, E., Swanson, K. (2019). Dexamethasone—Friend or Foe for Patients With Glioblastoma? JAMA Neurology 76(3) https://dx.doi.org/10.1001/jamaneurol.2018.4530 Retrospective post-hoc comparison of Decadron dose in NovoTTF vs. best physician’s choice (BPC) chemo.Patients were dichotomized to > or < 4mg/day. Improved survival seen in low Decadron dose group. NovoTTF patients: median OS 4.8mo vs. 11.0mo, BPC chemo patients: 6.0mo vs. 8.9mo (effect seemed to be more profound in TTF group). Wong, E., Lok, E., Gautam, S., Swanson, K. (2015). Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma British Journal of Cancer 113(2), 232-41. https://dx.doi.org/10.1038/bjc.2015.238 A combination of 3 retrospective human patient cohorts and a mouse model of GBM looking at the correlation of Decadron with survival after RT. Also compared VEGF inhibitor in mouse model.Found worsening mortality associated with Decadron in all 3 cohorts using a multivariate model. In mouse model, Decadron made radiation therapy ineffective. VEGF inhibitors were able to control edema without worsening outcome. Pitter, K., Tamagno, I., Alikhanyan, K., Hosni-Ahmed, A., Pattwell, S., Donnola, S., Dai, C., Ozawa, T., Chang, M., Chan, T., Beal, K., Bishop, A., Barker, C., Jones, T., Hentschel, B., Gorlia, T., Schlegel, U., Stupp, R., Weller, M., Holland, E., Hambardzumyan, D. (2016). Corticosteroids compromise survival in glioblastoma Brain 139(5), 1458-1471. https://dx.doi.org/10.1093/brain/aww046 First reference in the literature I could find to this effect.Tested the effects of adding dex to human glioma cell cultures, treated with vincristine, cytarabine, methotrexate (MTX), and adriamycin. Found that decadron attenuated the effect of all tested chemo agents. Weller, M., Schmidt, C., Roth, W., Dichgans, J. (1997). Chemotherapy of human malignant glioma: Prevention of efficacy by dexamethasone? Neurology 48(6), 1704-1709. https://dx.doi.org/10.1212/wnl.48.6.1704 Developed findings from Weller (1997) to look at mechanisms. Demonstrated that dDcadron inhibits apoptosis in human astrocytoma cells in culture. Gorman, A., Hirt, U., Orrenius, S., Ceccatelli, S. (2000). Dexamethasone pre-treatment interferes with apoptotic death in glioma cells Neuroscience 96(2), 417-425. https://dx.doi.org/10.1016/s0306-4522(99)00565-5 Phase II trial testing ipilimumab for brain melanoma mets. Included two cohorts: Cohort A - asymptomatic, Cohort B - symptomatic, taking Decadron. Cohort B survived longer. Was this due to worse disease, or the Decadron treatment? Margolin, K., Ernstoff, M., Hamid, O., Lawrence, D., McDermott, D., Puzanov, I., Wolchok, J., Clark, J., Sznol, M., Logan, T., Richards, J., Michener, T., Balogh, A., Heller, K., Hodi, F. (2012). Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial The Lancet Oncology 13(5), 459-465. https://dx.doi.org/10.1016/s1470-2045(12)70090-6

Lückenhaft und Pietätlos – Episode#088 – Badefrust Nach Badespaß kommt Badefrust, ist doch immer so. Wetter spielt nicht mehr mit und nicht mal sein Bier kann man anständig auf der Badewiese in guten, deutschen Freibädern trinken. Skandal! Wenigstens ist S. Hentschel wieder von den toten auferstanden um für Recht und Ordnung zu Sorgen. Gut so! Read more about Episode#088 – Badefrust[…] Der Beitrag Episode#088 – Badefrust erschien zuerst auf Lückenhaft und Pietätlos.

WEBSITE: www.hotelplanner.com BIO: Timothy Hentschel is co-founder and CEO of HotelPlanner and Meetings.com, the worldâ??s largest online group travel provider. He has served in this role since September 2003. In 2003, Hentschel and his business partner John Prince - software engineer and current COO of HotelPlanner - decided to pursue the creation of HotelPlanner. They pioneered the online group travel space, becoming a mainstay for group event planners and hotel partners alike. Today, HotelPlanner provides their group travel technology expertise to over 4,000,000 group event planners with over $7 billion in group hotel revenues passing through the HotelPlannerRFP system worldwide. FACEBOOK: www.facebook.com/hotelplanner TWITTER: @hotelplanner

Stacey J. Hentschel was acting on her childhood yearning to contribute to the world by touching people in ways that would bring them joy. Then, she was seized by a fatigue so intense she barely remembered her high-energy self. Her recovery deepened her compassion and empathy and taught her about the inner strength everyone has at a heart level. Since then, she has worked with thousands of people for over 25 years in developing visionary businesses and leaders and creating empowering relationships. She also facilitates the building of consciousness and sustainable organizations.

Shownotes:Last week's challenge:Falk challenged Jesse to read an article they had talked about where Nathan Fielder from Nathan for You was interviewed by a 67 year old mom who hates his show.http://www.avclub.com/article/nathan-yous-star-confronts-v-club-mom-who-scorned--226825Jesse challenged Falk to watch The Great Happiness Space.http://www.thegreathappinessspace.com/Falk did not complete his challenge.  His punishment is to make a 15 second dance video and upload it to the New Shit and Stuff instagram account: @NewShitAndStuffThings from our life:Not Saying “Like” As Muchhttp://www.wikihow.com/Stop-Saying-the-Word-%22Like%22WWE Hell in the Cellhttp://www.wwe.com/shows/hellinacellNow Watch/Zen Watch. (Post-it notes)http://zenwatch.com/Pumpkin Spice Pumpkin Seedshttp://www.traderjoes.com/digin/post/pumpkin-spiced-pumpkin-seedsTaking Walkshttp://www.wikihow.com/Take-a-WalkThings from DLC Podcast:http://5by5.tv/dlcDeath Note. https://www.netflix.com/title/70204970Pumpkin Bread.https://www.google.com/webhp?sourceid=chrome-instant&ion=1&espv=2&ie=UTF-8#q=pumpkin%20breadVictoria.  No link, because don’t google it.  It will ruin the experience.Things from Culture Gabfest:http://www.slate.com/articles/podcasts/culturegabfest.htmlComposer Zez Confrey:http://www.amazon.com/dp/B00Y2Y0IO8/?tag=slatmaga-20The ThermaPen:http://thermoworks.com/products/thermapen/?tw=SERIOUSEATSWelcome to Night Vale live show.http://www.welcometonightvale.com/live-events/Things from Political Gabfest:http://www.slate.com/articles/podcasts/gabfest.htmlThe Power of Obama’s Bully Pulpithttp://nymag.com/daily/intelligencer/2015/10/man-enters-rehab-after-hearing-obama-speech.htmlBastards of the Reagan Era.http://www.amazon.com/dp/1935536656/?tag=slatmaga-20An event at a cemetery in brooklyn where they tell life stories of the people buried there.  http://www.green-wood.com/Things from Scriptnotes:http://johnaugust.com/podcastTessy and Tab. http://www.tessyandtab.com/Buzzfeed Crossword Puzzles.http://www.buzzfeed.com/tag/crosswordsLogic-Puzzles.org.Things from Pop Rocket:http://www.maximumfun.org/shows/pop-rocketCarry Onhttp://www.amazon.com/Carry-Rainbow-Rowell/dp/1250049555/ref=asap_bc?ie=UTF8&tag=thesoundofyou-20The Cipher http://theciphershow.com/The Combat Jack Showhttp://thecombatjackshow.com/Huffpo’s Love and Sex Podcasthttp://www.huffingtonpost.com/news/huffpost-love-and-sex-podcast/Contact Us:NewShitAndStuff@gmail.comTwitter/Instagram: @NewShitAndStufffacebook.com/NewShitAndStuffhttp://traffic.libsyn.com/newshitandstuff/NSAS002.mp3

Our hosts, Jesse Lumen and Falk Hentschel, talk about New Shit they heard about or discovered this week, and other stuff.  They often go on tangents.Contact:NewShitAndStuff@gmail.com@NewShitAndStuffhttp://traffic.libsyn.com/newshitandstuff/NSAS001.mp3

Ute Hentschel is a professor of chemical ecology at the University of Würzburg in Germany. Her research focuses on characterizing the microbial communities associated with marine sponges, the diversity of these symbionts and their activities. On this episode, I talk with Ute Hentschel about her research on the microbes that live on and in sea sponges – those squishy, colorful residents of coral reefs. Dr. Hentschel describes some of the utterly unique microbes that are only found in sponges, what those microbes get from living in a sponge hotel, and why it’s nice to have a study site in the Bahamas.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.04.14.041863v1?rss=1 Authors: Nogueras-Ortiz, C. J., Mahairaki, V., Delgado-Peraza, F. M., Das, D., Avgerinos, K., Hentschel, M., Goetzl, E. J., Mattson, M. P., Kapogiannis, D. Abstract: We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer's disease (AD) patients contain high complement levels. To test the hypothesis that circulating EVs from AD patients can induce complement-mediated neurodegeneration, we assessed the neurotoxicity of immunocaptured AEVs (with anti-GLAST antibody), neuronal-origin NEVs (with anti-L1CAM antibody), and multicellular-origin (with anti-CD81 antibody) EVs from the plasma of AD, frontotemporal lobar degeneration (FTLD) and control participants. AEVs (and, less effectively, NEVs) of AD participants induced Membrane Attack Complex (MAC) expression on recipient neurons, membrane disruption, reduced neurite density, and decreased cell viability in rat cortical neurons and human IPSC-derived neurons. Neurodegenerative effects were not produced by multicellular-origin EVs from AD participants or AEVs/NEVs from FTLD or control participants, and were suppressed by the MAC inhibitor CD59 and other complement inhibitors. Our results support the stated hypothesis and suggest that neuronal MAC deposition is necessary for AEV/NEV-mediated neurodegeneration in AD. Copy rights belong to original authors. Visit the link for more info