Podcasts about GBM

Las sorpresas continuán en este 2026 y en este episodio Manolo y Omar analizan 3 jugadores que ofrecen la compra de acciones. ¿Están a la altura de GBM y Actinver? conoce lo que descubrieron nuestros Campeones

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #advocate #intercessor #fair #justice #acceptance #childrenofGod #friend #finalperseverance #trials #losesalvation #kepteternal #security #Job16-17 #John6v39 #John10v28-29 #Philippians1v6 Overviews of key themes as they unfold through the Bible. This occasional series focusses on the temple. #BibleThemes #biblicaltheology #tabernacle #sin #dayofatonement #cleansing #purification #sacrifices #priests #Jesusblood #effective #confidence #Godsholypresence #perfectfulfilmentinChrist #Hebrews9v11-14 #Revelation7v14 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

En este episodio Tito Neira conversa con Alejandro Correa Bahnsen (VP de Data & AI en GBM, PhD en Machine Learning, ex-Rappi y ex-Kavak) sobre por qué la mayoría de las empresas que "adoptan IA" no van a ver ningún resultado. Comprar la tecnología no es transformar: si no cambias tus procesos, en dos años vas a decir que "la IA no funcionó". Hablan de por qué los RAGs fallan en producción, qué son los EVALS (el tema del que nadie habla), por qué los Jupyter Notebooks son el nuevo Excel, y cómo el rol de Data/AI pasó de área de soporte a dueño de los KPIs del negocio.00:00 Intro y quién es Alejandro Correa02:39 Por qué los RAGs no funcionan en la práctica05:06 Cuándo sí usar RAG vs SQL06:45 Agentes: drag-and-drop vs agents as code11:18 EVALS: el tema del que nadie habla15:05 ¿Cuándo confiar en sacar la IA a producción?17:26 ¿Vale la pena cambiar de modelo cada semana?22:27 Los notebooks son el nuevo Excel27:07 Por qué dejó Python por TypeScript29:45 El rol de Data/AI: de soporte a dueño del negocio35:01 Predicción a 2 años: comprar IA no es transformar38:18 Cierre✩ CURSOS DISPONIBLES

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #hope #doubt #Godssovereignty #prosperity #trust #adversity #death #resurrection #forgiveness #suffering #glory #heaven #theloveofGod #Job11-15 #Romans8v17-18 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #unfair #complaining #Godangry #sorrow #honestyinprayer #undeserved #suffering #innocence #testoffaith #peace #kindness #sinful #speech #forgiveness #Job6-10 #1John2v1-2 Overviews of key themes as they unfold through the Bible. This occasional series focusses on the temple. #BibleThemes #biblicaltheology #tabernacle #Godspresence #HolyofHolies #MostHolyPlace #arkofthecovenant #throneroom #lampstand #tableofbread #fellowship #meals #communion #goldenaltar #incense #Exodus25-27 #Hebrews4v16 #Revelation5v8 #Revelation19v6-10 #Revelation22v1-2 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

Send us Fan MailSometimes we hear about a vision for a trial that is so novel and exciting that it takes you back a bit.This is one such moment.Join us as we talk to the amazing Dr Faye Robertson from the Edinburgh cancer Centre about the ingenious ADePT trial.DUAL PAYLOAD GENE THERAPY.Led by Trogenix and the University of Edinburgh, it tests a breakthrough "Trojan horse" gene therapy designed to destroy cancer cells and stimulate the immune system.TGX-007 is a drug developed with Tregonix that:How it Works: It uses dual-payload technology to deliver two distinct therapeutic agents:HSV-tk: Converts an orally administered antiviral drug (valaciclovir) into a toxic agent that directly kills proliferating tumour cells.IL-12: Acts as an immune-stimulating cytokine that turns the tumour into an in-situ vaccine, training the body's immune system to attack the cancer and prevent recurrence.We have had many false dawns in GBM trials but we are very excited by the results so far with TGX-007.Part 1 of 2 and this is a trial story we want to follow through.Enjoy!!!

Check out this week's QuadCast as we highlight testosterone replacement in favorable prostate cancer, SABR for breast cancer without surgery, smaller GBM margins, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #Sympathy #kindness #discipline #Godssovereignty #Godsjustice #theloveofChrist #ProsperityGospel #suffering #punishment #Job4-5 #Romans8v35 Overviews of key themes as they unfold through the Bible. This occasional series focusses on the temple. #BibleThemes #biblicaltheology #temple #GardenofEden #God #placeofworship #Godsimage #multiplied #earth #patriarchs #Abraham #Isaac #Jacob #mountain #altar #Godspresence #MountSinai #Moses #holiness #Genesis1v28 #Genesis12v3 #Genesis35v11 #Exodus19 #Acts6v7 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

En este episodio en colaboración con GBM, invitamos a tres mujeres increíbles que saben muchísimo de finanzas: Miriam Acuña, Head Economist de GBM, Gabriela Fernández, Head of Product & Investment Solutions de GBM y Daniela Becerril, asesora financiera. Si alguna vez has sentido vergüenza por no entender de finanzas, miedo a revisar tu cuenta bancaria o frustración porque parece imposible ahorrar, este episodio es para ti.Basándonos en las preguntas que ustedes, la comunidad de Se Regalan Dudas hicieron, hablamos de todo eso que muchas veces nos da pena preguntar sobre dinero: cómo empezar a ahorrar, cómo salir de deudas, qué hacer con las tarjetas de crédito, cómo hacer crecer mi dinero, cómo pensar en el retiro y hasta cómo hablar de finanzas en pareja. Pero también hablamos del miedo, la culpa, el FOMO, la presión social y la ansiedad que puede generar sentir que “no nos alcanza” o que ya deberíamos tener resuelta nuestra vida financiera.Es una conversación muy honesta, cercana y fácil de entender sobre dinero. Una conversación entre mujeres, para mujeres. Si quieres conocer más de GBM entra a: gbm.com/dudasSuscríbete para encontrar nuevos episodios todos los martes y jueves. Si quieres contenido exclusivo, estar al tanto de todo lo que hacemos y ser la primera persona en enterarte de todo lo nuevo que pasa en Se Regalan Dudas suscríbete a nuestro newsletter en seregalandudas.com/suscribete —--------Se Regalan Dudas es el espacio creado por Lety Sahagún y Ashley Frangie para cuestionarlo todo. Lo que nació como un proyecto entre amigas, hoy es el podcast número uno de habla hispana, reconocido por su impacto en temas de salud mental, amor propio, relaciones de pareja y bienestar emocional.Si buscas entender mejor tu sexualidad, sanar vínculos familiares o simplemente navegar el crecimiento personal, este es tu lugar.¿Dónde escucharnos?Encuentra nuevos episodios y contenido exclusivo en YouTube, Spotify, Apple podcasts, Amazon Music. Las opiniones y puntos de vista expresados por Lety y/o Ash o cualquier persona invitada son de su exclusiva responsabilidad y no necesariamente reflejan la opinión personal de Lety y/o Ash o de cualquier persona que trabaja en el equipo de Se Regalan Dudas.¡Latinoamérica!

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #Poetry #sympathy #wishingtodie #depression #despair #grief #Triumph #sorrow #hope #prayer #Job2v11-3:26 #Philippians2v27 #Matthew26v38 #1Peter1v3-6 Overviews of key themes as they unfold through the Bible. This occasional series focusses on the temple. #BibleThemes #biblicaltheology #temple #GardenofEden #God #dwell #life #treeoflife #riveroflife #walking #Adam #firstpriest #tabernacle #restoration #Genesis3v8 #Genesis2v15 #Numbers3v7-8 #Revelation 22v2 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #Satan #sickness #sovereigntyofGod #faithfulness #suffering #Temptation #trials #loveofGod #poverty #cross #comfort #Job2v1-10 #2Corinthians8v9 A pastor talks to his people from the Bible about different issues that many of them face. #Pastoral #Pastor #Unity #humble #gentle #patient #arrogant #compassion #kindness #humility #gentleness #peace #Matthew11v29 #Ephesians4v1-6 #Philippians2v8 #Colossians3v12 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

The following article of the Finance & Fintech industry is: 'The Biggest Investing Mistake: Not Asking' by Luis Felipe Madrigal Mier y Terán, Director GBM Advisors, GBM. 

In today's episode the team talks all the negative publicity WWE has received because of TKO, Nando T compares them to the Dallas Cowboys. Questions rise about the commitment to WWE and how it's been extremely taxing being a fan. How can we continue being a fan and supporting the assholes running TKO!?! All this and much more......CHEERS!!!JERKING THE CURTAINROUND TABLE OF TOPICSNEWSBlack Friday hits harder than before….very long list Rumors of talent being asked to take a pay cut The New Day walks away from a contract offer…..end of an era Chelsea has successful heart surgery “You Just Made the List” Top 5 WWE talent losses from Black Friday SMACKDOWNFatu gets a message from the Usos, will he listen???Royce Keys taking the offer from Solo? Kiana James needs a push Truth saves the Gingerbread man funeral Charlotte and Rhea build up???Talla Tonga wrestling is great for business Would Gunther and Heyman be good business or would Cody and Heyman be grrrrreat for business Matt Cardona continues to be used like Michin Johnny Wrestling saving the GBM funeral How are we feeling about Fatal Influence???Women's division is looking solid again How is Keys related to the Bloodline???I cannot tell a lie…..Gingerbread man skit was good BACKLASHI gotta give WWE credit for a great PLESeth vs BronTrick vs Sami DanHausen/MiniHausen vs Miz/Kit Wilson Match of the night goes to Asuka and Iyo…..is Asuka leaving???Roman vs Fatu……too soon or the right seed to plant???RAWRoman wants a Fatu acknowledgment Street Profits return is mid at best Joe Hendry mocking Logan Paul is good for businessEgo vs Penta for SNME is good for business Is Asuka done with WWE??? Notice the make up Liv vs Paige would be great for business Wow Sol gets the genius of the sky for her RAW debut Oba grabbing two wrestlers from the back for a match was good writing Finn crashing Doms match is grrrrreat for business Not that I care but what was Maxine doing in the car with the Vision???Fatu destroys the OTC, what's next???NXT/TNANXT has been a very hard watch10 count with Always Ready Arianna Check out the Smackdown Siblings on TikTok @ariannaandthomasEpisodes dropping weekly!!!Follow us on TikTok @the.funkaholiks.pod THEE POD THAT TALKS WHAT THEY LOVE 

Ossama El Samadoni leads GBM, one of the most respected technology organisations in the region, with over 300 employees, triple-digit million dirham revenue, and clients across the Middle East, Africa, Turkey and Russia. The disappointment that derailed his dream is exactly what built him. But this isn't a story about career pivots. It's a conversation that should make every business leader in this city sit up straight. Ossama has spent decades at the intersection of global technology and human vulnerability working with Dell, Oracle, HP, and IBM before taking the helm at GBM. He's seen cyber attacks quadruple during regional conflict. He's watched AI agents invent their own secret language when they detected they were being supervised. He's tracked state actors who wiped entire company systems without issuing a single delete command. And he's deeply worried that most leaders still don't understand what's already here. This is a rare conversation Ossama's first podcast and he gives everything. No corporate script. No polished PR lines. Just a trench fighter who trusts primary information over secondary noise, believes technology should serve human welfare not just profit, and will tell you plainly: it's not if you'll be attacked, it's when. Whether you're a founder, a CEO, or just someone trying to understand what AI is actually doing to our world this one will stay with you.   Timestamps:  0:00 – "A podcast virgin" Osama's first ever appearance 0:09 – Employees feeding company data into ChatGPT: the risk nobody talks about 2:11 – How generative AI actually works and why bias is already baked in  5:38 – The moment two AI agents invented their own secret language to hide from their supervisor  13:34 – Cyber-attacks quadrupled during regional conflict and why every company is a target 19:21 – How a demo system became a state actor's entry point  22:21 – The KPMG case: an entire system wiped with zero delete commands 25:56 – Password hygiene, the 14-day rule, and why you must never open junk mail in Outlook  28:39 – How to spot AI snake oil salesmen and the two questions that cut through the noise 30:13 – Deepfakes are already here and why trust will return to the room  47:10 – Made in Egypt, polished in UAE and why Dubai is harder than it looks  57:32 – If he started again at 21: invest in human welfare, not hype 59:35 – Leading from the trenches and the multiplier effect of great leadership  1:04:50 – Quickfire: rogue AI, the one question every CEO should ask, and more    Follow Spencer Lodge on Social Media: https://www.instagram.com/madeindubaipodcast/?hl=en https://www.facebook.com/profile.php?id=61586194260076 https://www.instagram.com/spencer.lodge/?hl=en https://www.tiktok.com/@spencer.lodge https://www.linkedin.com/in/spencerlodge/ https://www.youtube.com/c/SpencerLodgeTV https://www.facebook.com/spencerlodgeofficial/   Follow Ossama El Samadoni on Social Media:  https://www.linkedin.com/in/ossamae/ https://www.linkedin.com/company/gbm/ https://www.instagram.com/gbmmiddleeast/

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. ‘Grief doesn't mean we are spiritually weak. We must not judge the Christian who is hurting' #PreachingJob #Blessing #Satan #trials #faith #disasters #suffering #pain #SovereigntyofGod #worship #submission #wealth #possessions #Poverty #grief #Job1v13-22 A pastor talks to his people from the Bible about different issues that many of them face. #Pastoral #Pastor #faithfulness #trust #consistent #faithful #faith #Lamentations3v22-23 #1Thessalonians5v24 #Hebrews11v6 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

May is Brain Tumor Awareness Month. In this episode, meet two new TGen researchers whose shared love of science—and math—first brought them together in the lab and later in life. Drs. Simona Migliozzi and Luciano Garofano are married to each other and to their work. They discuss their education in Italy, their research journeys across institutions in the U.S., and the path that ultimately led them to TGen, where Dr. Garofano's expertise in math and statistics pairs seamlessly with Dr. Migliozzi's passion for improving outcomes for patients with glioblastoma. You'll also hear about their individual contributions to the growing body of GBM research and learn which partner believes the other is the true “smart one” in the partnership.

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #PreachingJob #Test #goodness #blameless #faith #conversion #Satan #prosperitygospel #blessed #loveofGod #example #wealth #Job1v1-12 A pastor talks to his people from the Bible about different issues that many of them face. #Pastoral #Pastor #faithful #Contentment #Paul #Godsplan #circumstances #happiness #Godsstrength #purposes #glory #Philippians4v11-13 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

The following article of the Finance & Fintech industry is: 'Why Your Portfolio Needs Global Diversification' by Andrés Maza, CIO, GBM.

A guide to help you to preach from the Old Testament book of Job. It will also be of use in giving pastoral help to individual people who are going through painful experiences. #Riches #suffering #trust #poetry #emotions #anger #Job #faith #grace #depression A pastor talks to his people from the Bible about different issues that many of them face. #Pastoral #Pastor #Confident #Faith #belief #devotion #trust #oppression #promise #Noah #trust #hope #Hebrews1v1-3 #Hebrews11:1 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

Early bird discounts for the San Francisco World's Fair, the biggest AIE gathering of the year, end today - prices will go up by ~$500 tonight so do please lock in ASAP!From near-universal AI tool adoption inside Shopify to internal systems for ML experimentation, auto-research, customer simulation, and ultra-low-latency search, Mikhail Parakhin joins us for a deep dive into what it actually looks like when a 20-year-old, $200B software company goes all-in on AI. We cover why Shopify has become much more vocal about its internal stack, what changed after the December model-quality inflection, and why the real bottleneck in AI coding is no longer generation, but review, CI/CD, and deployment stability.We also go inside Tangle, Tangent, SimGym, which are three major AI initiatives that Shopify is doing to make experimentation reproducible, optimization automatic, customer behavior simulatable, and search and catalog intelligence faster and cheaper at scale. Along the way, Mikhail explains UCP, Liquid AI, and why token budgets are directionally right but often measured badly, why AI-written code can still increase bugs in production, what makes Shopify's customer simulation defensible, and what he learned from the Sydney era at Bing.We discuss:* Mikhail's path from running a major Microsoft business unit spanning Windows, Edge, Bing, and ads to becoming CTO of Shopify* Why Shopify is talking more publicly about AI now, and why staying at the frontier has become necessary for the company* Shopify's internal AI adoption curve, the December inflection, and why CLI-style tools are rising faster than traditional IDE-based tools* Why Jensen Huang is directionally right on token budgets, but raw token count is still the wrong way to evaluate engineering output* Why the real unlock is not more agents in parallel, but better critique loops, stronger models, and spending more on review than generation* Why AI coding can still lead to more bugs in production even if models write cleaner code on average than humans* Why Shopify built its own PR review flow, and why Mikhail thinks most off-the-shelf review tools miss the point* How PR volume, test failures, and deployment rollback are becoming the real bottlenecks in the agent era* Why Git, pull requests, and CI/CD may need a new metaphor once code is written at machine speed* What Tangle is, and how Shopify uses it to make ML and data workflows reproducible, collaborative, and production-ready from the start* Why Tangle is different from Airflow, and why content-addressed caching creates network effects across teams* What Tangent is, and how Shopify is using auto-research loops to optimize search, themes, prompt compression, storage, and more* Why Tangent is becoming a democratizing tool for PMs and domain experts, not just ML engineers* Why AutoML finally feels real in the LLM era, and where auto-research still falls short today* Why Tangle, Tangent, and SimGym become much more powerful when combined into one system* What SimGym is, why simulated customers only work if you have real historical behavior, and why Shopify's data gives it a moat* How SimGym evolved from comparing A/B variants to telling merchants what to change on a single live storefront to raise conversions* Why customer simulation is so expensive, from multimodal models to browser farms to serving and distillation costs* How Shopify models merchant and buyer trajectories, runs counterfactuals, and thinks about interventions like discounts, campaigns, and notifications* Why category-level behavior is so different across commerce, and why ideas like Chinese Restaurant Processes are showing up again in practice* Shopify's new UCP and catalog work, including runtime product search, bulk lookups, and identity linking* Why Shopify is using Liquid AI, and why Mikhail sees it as the first genuinely competitive non-transformer architecture he has used in practice* Where Liquid already works inside Shopify today, from low-latency query understanding to large-scale catalog and Sidekick Pulse workloads* Whether Liquid could become frontier-scale with enough compute, and why Shopify remains pragmatic and merit-based about model choice* Who Shopify is hiring right now across ML, data science, and distributed databases* The Sydney story at Bing, why its personality was not an accident, and what Mikhail learned from deliberately shaping AI character early onMikhail Parakhin* LinkedIn: https://www.linkedin.com/in/mikhail-parakhin/* X: https://x.com/MParakhinTimestamps00:00:00 Introduction: Mikhail Parakhin, Microsoft, and Shopify00:01:16 Why Shopify Is Talking More About AI00:02:29 Internal AI Adoption at Shopify and the December Inflection00:06:54 Token Budgets, Jensen Huang, and Why Usage Metrics Can Mislead00:10:55 Why Shopify Built Its Own AI PR Review System00:12:38 AI Coding, More Bugs, and the Real Deployment Bottleneck00:14:11 Why Git, PRs, and CI/CD May Need to Change for Agents00:18:24 Tangle: Shopify's Reproducible ML and Data Workflow Engine00:21:19 Why Tangle Is Different from Airflow00:26:14 Tangent: Auto Research for Optimization and Experimentation00:30:07 How Tangent Democratizes Experimentation Beyond ML Engineers00:33:06 The Limits of Auto Research00:36:36 Why Tangle, Tangent, and SimGym Compound Together00:37:20 SimGym: Simulating Customers with Shopify's Historical Data00:42:47 The Infra Behind SimGym00:46:00 Why SimGym Gets Better with Real Customer History00:47:30 Counterfactuals, HSTU, and Modeling Merchant Trajectories00:51:55 CRPs, Clustering, and Category-Level Customer Behavior00:53:30 UCP, Shopify Catalog, and Identity Linking00:55:07 Liquid AI: Why Shopify Uses Non-Transformer Models00:59:13 Real Shopify Use Cases for Liquid01:03:00 Can Liquid Scale into a Frontier Model?01:09:49 Hiring at Shopify: ML, Data Science, and Databases01:10:43 Sydney at Bing: Personality Shaping and AI Character01:13:32 Closing ThoughtsTranscript[00:00:00] swyx: Okay. We're here in the studio, a remote studio, with Mikhail Parakhin, CTO of Shopify. Welcome.[00:00:08] Mikhail Parakhin: Thank you. Welcome.[00:00:10] swyx: I don't even know if I should introduce you as CTO of Shopify. I feel like you have many identities. Uh, you led sort of the, the Bing ML team, I guess, uh, uh, or ads team. I, I don't know, I don't know, uh, you know, it's, uh, people va-variously refer you as like CEO or, or, uh, I don't know what that, that, that said previous role at Microsoft was.[00:00:29] Mikhail Parakhin: Uh, that was... Yeah, my previous role w- at Microsoft was the-- I actually was the CEO of one of Microsoft's business units, which included, as I, you know, as we discussed, all the things that people like to laugh about, uh, including Windows and Edge and Bing and ads and everything.[00:00:47] swyx: Yeah, yeah. What a, what a, what a wild time.You've obviously, uh, done a lot since you landed at Shopify. Uh, one of the reasons I reached out was because you started promoting more sort of internal tooling, uh, primarily Tangle, but also a lot of people have seen and adopted Tobi's QMD, uh, and obviously, I think, uh, Shopify has always been sort of leading in terms of, uh, engineering.I think more-- it's just more recent that you guys have been more vocal about your sort of AI adoption. Is that, is that true?[00:01:16] Mikhail Parakhin: Well, I think AI tools in general are fairly recent development, uh, and we've-- Shopify, you know, at this stage of its development, we're developing AI in-in-house and other, uh, building tools that use AI and, you know, interfacing with the wider AI community, uh, you know, are on the sort of the, uh, runaway trajectory.So it just did by sort of natural byproduct. We, we talk about it more also. We just, uh, just even yesterday, Andrej Karpathy was famous in tweeting about, oh, are there some, uh, ways, uh, that, that you can organize your agents to store the data and then, uh, look up the data so that you don't have to research or, or lose context every- Yestime. And a little bit tongue in cheek, I tweeted that, “Hey, we've, we've done it much earlier, and we even have different approaches, Tobi and I.” Tobi, of course, is a big fan of QMD, and I'm more of a SQL, SQLite fan. But, uh, yeah, very similar things that we've already done here. The point is, yeah, we're very dynamic, you know, explosively growing company, and we have to be at the forefront of AI adoption, obviously.[00:02:29] swyx: Yeah. Yeah. Um, you, your team kindly prepared some slides actually that we were gonna bring up on to, uh, the screen. I think I can, I can screen share, and then we can kind of go through some of the shocking stats that maybe, maybe put some numbers to what exactly is going on. So here we have, uh- An internal AI tool adoption chart.What are we looking at here? What ?[00:02:54] Mikhail Parakhin: Yeah, this is very interesting statistics. Uh, this is number of daily active workers, you know, think of, uh, DAO, basically the active users of-[00:03:05] swyx: Yeah ...[00:03:05] Mikhail Parakhin: AI tool as a percentage of all the people in the company, right? And then- Yeah ... different AI tools. And, uh, you could see two things here is that one is the green is total.Uh, green is just total. So you could see that it approaches really % by now. It's hard not to do your job now without interacting deeply, at least with one tool. You could see another interesting thing is just as many people commented in December was the phase transition when suddenly models gotten good enough that, that everything took off and started growing.Uh, it, it was many people noticed that the thing is that small improvements accumulated into this big change in Sep- December roughly timeframe.[00:03:52] swyx: Yeah.[00:03:52] Mikhail Parakhin: The other thing I would claim you could see is that, uh, CLI-based tools and tools that don't require you to look at the code becoming more popular, and you could see, yeah, various versions of, uh, Cloud Code and Codex and Pi and internal development tools taking off.Uh, exactly, yeah, uh, and blue is our River, just internal agent for coding, where tools, uh, that require IDEs such as, uh, GitHub, Copilot or Cursor, they're not exactly shrinking, but they're not growing as fast. Like, uh, red, red line is, is the IDE kind of tools. So you could see that they're, they're not experiencing as, as fast of a growth.[00:04:37] swyx: As I understand it, basically, every employee has their choice, right? Of choose whatever tool you use, and then you're just kind of doing a, a daily sur-survey or something.[00:04:47] Mikhail Parakhin: Exactly. And, uh, we- Yeah ... the, the push is to get your job done, you can use any tool, and we effectively fund unlimited tokens for everybody.Uh, we, we do, we do try to control the models that, uh, people use, but from the bottom, not from top. Like we basically say, “Hey, please don't use anything less than Opus four point six.”[00:05:09] swyx: Oh .[00:05:10] Mikhail Parakhin: Some people, some people end up using GPT five point four extra high. Some people use Opus four point six. Um, uh, you know, uh, there are some, uh, there are plus and minuses in going for full one million context window versus not.But, uh, we try to discourage people from using anything less than that.[00:05:28] swyx: Yeah, yeah. Got it, got it. Uh, I mean, uh, that's, you know... The, the next chart here, it really kind of shows the expansion and the sort of December twenty twenty-five inflection, right? That, uh, people are using a lot of tokens. I think it's also really interesting that no one was kind of abusing it in twenty twenty-five.Like it was- Had comparatively, uh, to this year, there was almost no growth. I mean, it's still like, you know, probably, probably gave fifty percent.[00:05:56] Mikhail Parakhin: Yeah. This is just a different scale. It's still exponential- Yeah, yeah ...growth at just a different- ...rate of expansion. Uh, there was inflection point, and Sean, I would claim the, the super interesting part here is that you could see that the distribution becoming more and more skewed.Yes. The top percentiles grow faster. So that means- Yeah ...the people in the top ten percentile, they, their consumption grows faster than seventy-five and so forth. So, uh, the distribution skews more and more towards the highest users, which is... I don't know what it tells me. It's like it feels not ideal, to be honest.Or maybe it's okay. We'll see.[00:06:36] swyx: Why does it feel not ideal? Is, is it because of, um, quantity over quality, or what's the concern?[00:06:42] Mikhail Parakhin: Because take it to the limit. That means, you know, if, if this rate of separation continued- Ah, yes ...a year, there will be one person consuming all the tokens. So it's just, it's kinda strange.[00:06:54] swyx: Yeah, I mean, um, uh, I, I think internal like teaching and all that, uh, will, will help sort of distribute things more widely. But in, in the early days, of course, the people who are sort of more AI-pilled will obviously find more ways to use it than the people who are less AI-pilled. Maybe let's, let's call it that.I'll just, I'll just kinda quickly, uh, pause from the, the... You know, we will go back to the rest of the slides, but I just wanna, um, review, you know, there are a lot of CTOs of, of large companies like yourself where they're all considering some kind of token budget, right? Like I think it's something, something that Jensen Huang has been talking about, where like if your 200K engineer is not using 100K of tokens every year, like they're, they're underutilizing coding agents.Of course, Jensen Huang would say that, but like it seems a very quantity over quality approach and like some, some people are basically saying like, well, is this comparable to judging engineer quality by lines of code, right? Which we also know is like kind of flawed, but better than nothing. So I, I don't know if you have like a sort of management take here on, on how to view this kind of, uh, metrics.[00:08:02] Mikhail Parakhin: Well, I mean, you're, you're baiting me. I, I like... This is my favorite topic. Uh, if you let me, I'll probably talk for two hours on just this. I have a lot of things to say. Like I do think Jensen gotten a lot of bad press saying, “Oh, of course you're, you know, this, uh, the- ...the cake seller says you don't need enough cakes.”You know? Like, of course. Uh, but, uh, I actually, uh, think that's undeserved. I think he, he's actually right. Uh, I do think- He,[00:08:33] swyx: he's directionally correct.[00:08:35] Mikhail Parakhin: Yeah. Yeah. He's directionally correct for sure. Uh-[00:08:37] swyx: Who knows what the right number is? Yeah.[00:08:39] Mikhail Parakhin: The thing that I do Uh, want to say, and this is something that we learned through trial and error and very important is like two things.One is that it's not about just consuming tokens. Uh, you can consume tokens and, and in fact, the anti-pattern is running multiple agents, too many agents in parallel that don't communicate with each other. That's almost useless, uh, compared to just fewer agents and burns tokens very efficiently. Uh, setting up the right critique loop, especially with the high quality models, where one agent does something, the other one, ideally with a different model, critiques it, uh, suggests ways to improve it, the agent redoes it with this critique and, and so it takes much longer.So people don't like it because latency goes up. You know, they, they have to wait until this debate is happening. But, uh, the quality of the code is much higher. And another thing, just since you mentioned like, look, uh, uh, yeah, the overall budget is just like, uh, lines of codes. Lines of codes are exploding for everybody right now, or partially because AI is really mover balls, but partially just because AI can write a lot more code, you know, doesn't get tired.And so you have to have to have a very strong narrow waist during PR review. Otherwise, just the number of bugs will go through the roof. It's, uh, it's this unexpected consequence of the just volume trumping everything. I would claim by now good model writes code on average with fewer bugs than, than the average human.But since they write so much more of it, like more of it will make it into production. So you have to- You still[00:10:26] swyx: have[00:10:26] Mikhail Parakhin: more bugs. Yeah. Have to have a very rigorous PR reviews, also automated of course. But, uh, yeah, that to spend a lot budget there. Like this, this for me, for me, actually, the important metric is the ratio of budget spent during code generation versus, uh, spent, uh, expensive tokens like GPT, uh, five point four Pro or, uh, uh, Deep Think from Gemini, you know, checking on PR reviews.[00:10:55] swyx: Yeah, totally. Uh, I noticed in your chart you didn't have any review tools. Do you just use like, like let's say a Claude code to review tools? Or do you have another set of review tools like the Greptiles, the Code Rabbits, uh, Devin Reviews has a review tool. I don't know if you've had those specialist review tools.[00:11:13] Mikhail Parakhin: You are a little bit jumping on my store tool right now because the graphs I was only showing public tools. Uh, uh, the-- I haven't found a good PR review tool that, that does what I think should be done. And, uh, partially my, my thinking is because it's so... It just goes against both what people feel like emotionally they prefer and, uh, some of the, uh, you know, frankly Even business models that, that the companies run.At peer review tool, uh, time, you want to run the largest models. That means, I don't know, Codex or, or, uh, Cloud Code is not gonna cut it. You need to have pro-level models if you really want to, uh, stand the tide of bots from going into production. And you need us to spend a lot of time, the models taking turns, but you don't want, like, a big swarm of, uh, of, uh, agents.So in fact, you end up in a different dual-dualistic world where you generate not that many tokens. You, in fact, generate few tokens, but it takes f-a long time because these are expensive models taking turns rather than many, many agents trying to do many things in parallel. So that's, that's why I feel like I haven't found good tools, so we are using our own for peer review for now.[00:12:33] swyx: Yeah. Yeah. I mean, uh, I think a lot of companies are building their own, uh, especially to their needs, right?[00:12:38] Mikhail Parakhin: Mm-hmm.[00:12:38] swyx: Um, I, uh, you also have a chart here going back to the slides on, uh, PR merge growth, where we're now at thirty percent, uh, month on month rather than ten percent. Uh, and also the, the estimated complexity is going up.You know, this is productivity, right? ‘Cause y- presumably there's more stuff going into the code base and more, more features getting worked on. I'm curious about the backlog, right? Like the, the, the-- I actually don't mind a pro-level model taking an hour or two hours to review my PR, because I've dealt with humans who take a week to review my PR, right?And I keep pinging them on Slack, “Hey, hey, review my PR.” So, you know, I think there's some trade-off here where, like, it still doesn't make sense.[00:13:18] Mikhail Parakhin: Exactly. That, that's exactly m-my point. Uh, that on one hand, you can tolerate longer latencies at, uh, PR. On the other hand, like right now, the real problem is not in spending time waiting for PR.It's real problem is since there's so much more code than- Yeah ... uh, probability of at least some tests failing going up, and then you, like, keep de-failing, then you have to find the offending PR, evict it, retest it without that PR, and so deployment cycle becomes much longer. Uh, so it actually, in terms of the overall time to deploy, it's total time savings if you spend more time on a longer model, like thinking for an hour, because then, then you, you don't have to spend all that time during testing and rolling, you know, rolling back the deployment.[00:14:03] swyx: Yeah, totally. That's still worth it. You know, you don't look at the individual, look at the aggregate, and look at the, the, the change in the aggregate system.[00:14:11] Mikhail Parakhin: Exactly.[00:14:11] swyx: I'm kind of curious if, like, there's this PR mentality and, like, c-- the, the, the CICD paradigm will be changed eventually. Some people are like, obviously a lot of people want new GitHub, but I even wonder if, like, Git is the problem, right?Like, is that the bottleneck? Is the concept of a PR a bottleneck? Do you guys use stack diffs? I don't know if, uh, that's a, like, a merge queue stack diff type of thing.[00:14:34] Mikhail Parakhin: We, we use, we use Stacks, we u- we use Graphite. We worked with, uh, Graphite a lot. Uh, so we use Stack, uh, PRs. I think, uh, like that's clearly the overall CICD in general, and the interaction with the code repository right now is the, clearly the sort of the, the main issue and the bottleneck for us, uh, and highest top of mind.I would say we probably need a different metaphor or different whole design of how to process it in new agentic world. I haven't seen anything dramatically better yet. I, I think everybody right now is just trying to keep their head above the water ‘cause, ‘cause there, there's so many PRs and then everybody's CICD pipelines start creaking, the, the times are increasing, the number of bugs slipping by increasing, and you have to, have to clap on down.And so we are a little bit in this situation when we need to first stabilize that story and then start thinking, hey, what, what it could be a completely different and new world, which I haven't... I know some people working on it. I haven't seen something, like anything super compelling yet, but clearly the old thing were designed for humans will need to be morphed into something new.[00:15:53] swyx: One of the thing that I, I think about is kind of like the merge conflict is basically a global mutex on the whole system, right? And in, in hu- in human organizations, we do have something like that. It's the company standup. But like, other than that, it's like it's actually fitting for us to be somewhat decentralized, somewhat plugged into one stream of information source, but somewhat lossy.Like it's okay, you know, that, that not every delivery is like atomic consistency. Like we're not dealing with a database sometimes.[00:16:27] Mikhail Parakhin: This is a very good point, uh, because since humans don't write code too fast, you know that global mutex is not too bad. Once you-[00:16:36] swyx: Yes ...[00:16:37] Mikhail Parakhin: start writing code at the speed of machine, it becomes the, you know, the bottleneck.Then what do you do? Maybe, and I can't believe I'm saying this because I, I'm long-- lifelong opponent of, uh, microservices, and I always thought that was, like, a really bad idea. And now that you're saying it, like, maybe in new guys like microservices will make a comeback, you know, because then you, you can ship things independently in tiny things and, and the managing all that complexity automatically will be much easier.I don't know. Like, we'll s-- we'll have to see.[00:17:10] swyx: Yeah. I mean, I don't know what the Microsoft or, or Shopify thing is, but I, I read this paper from Google where they have a monorepo that deploys into microservices, right? And then, uh, the other concept that I think about a lot is the Chaos Monkey concept from, from Netflix.Being able to create, like, this robust system where, um, uh, you know, you, you have the service discovery, you have the, uh, the independent, independent microservices discovery and, and, uh, you know, probably going to be a fair amount of duplication. That's how an organic system sort of scales, uh, that, that you have that...I don't know how you call it. Slack? Robustness? Depend-- uh, d-duplication. I, I, I forget the-- I, I'm-- And this-- those-- these are not exactly the terms- Hmm ... I'm looking for, but I c-can't really think of the words. Okay. I was gonna go into Tangent and Tangle. Uh, so, uh, we, we sort of discussed the overall stats that, uh, Shopify has.Uh, but, you know, I, I think some, some pretty cool stuff that you guys are working on is your ML experimentation, uh, and your, your sort of auto tr-research training pipeline. Presumably you're much closer to this one because it's, it's a sort of personal hobby of yours. How, how would you explain them in, together?I thought we have a slide that, like, uh, has the s- the system diagram.[00:18:24] Mikhail Parakhin: Yeah. Tangle first and then Tangent as a-[00:18:27] swyx: Yeah ...[00:18:28] Mikhail Parakhin: as a thing on top of Tangle. And, uh, Tangle is the third generation, I claim, of, uh, systems of, uh, running any data processing, but a bit with a skew for ML experiments, but not necessarily. Any sort of data processing tasks where you need to iterate, share, and you have scale so that you want maximum efficiency.You know how, like, normally you would work, you would-- Imagine you're a data scientist or an ML practitioner, you would get Jupiter notebooks or, or maybe you would get, uh, you know, Pyth- your Python scripts, and you would manage the data, and you produce those TSV files, and you put them in some JFS or something.Then you would notice that, oh, it has this, uh, weird missing values. You go and write another script that, uh, goes and replaces them with, uh-[00:19:20] swyx: Ah ...[00:19:21] Mikhail Parakhin: dash S. And then, then you, then you run some, some, uh, “Oh, I need to filter bots.” And so you run some light GBM model that, uh, removes the bots. And then, then you like-- And then you, you kind of like get into shape, and then you start experimenting, and you run multiple experiments, and then you're like, “Oh my God,” like, “this experiment is worse.”You undo, and you cannot get to previous result. And like, “Ah, what did I do?” Like that. Again, then, then you finally like get everything working. Then you like start throwing it over the fence to production. You, you replicate it, those things don't work, and then sometimes you like don't notice that you forgot some feature naming and the, the features don't match.But then, like imagine you, you did everything, and then six months later you're like, have to repeat it because now there's more data, or you wanted to do another pass, and you're like, “What, what did I do?” Or like, or like, “This script crashes now,” or the, “the path has changed.” And then, then you're trying to, like you spend another month just doing ar- digital archeology on your own, you know, history, right?Now multiply that by many, many teams. Now imagine you got an intern that you wanna ramp up. Now you have to show that intern, “Oh, you know, look, here's the folder, there's the scripts, you know, ask your cloud agent to do, and then, uh, to, to figure it out.” And then cloud agent does something, and then you're, “Ah, yeah, right, right, it was the wrong folder.I forgot to tell you, I actually have this other thing I forgot myself.” And, and that's, that's the, like, the daily life we all, uh, all know it, uh, if, if you're a data scientist, machine practitioner, ma- machine learning practitioner or, uh, or even like any data managing, uh, person.[00:21:00] swyx: Yeah. So I, I used to do this, uh, f- uh, on the quant finance side, uh, in, in my hedge fund.So we did this before Airflow, and then, uh, obviously Airflow came along and, uh, then more recently Dagster, uh, I would say is like, in my mind, what I would use for that shape of problem, uh, where you had to materialize assets and create a pipeline.[00:21:19] Mikhail Parakhin: And that's, that's very good segue because... So Airflow is great, but Airflow is more about you, you have something and you wanna repeatedly run it in production on schedule.It's less about you as a team developing things and being able to share, and you grabbing the standard pipeline and saying, “Hey, I wanna change this tiny little component in the huge sea of data processing, and I don't wanna-- I wanna run ten experiments on this, and I wanna do hyperparameter optimization.”All that is very hard to do with Airflow. It's very easy to do with Tango. Tango is m- more about, it's everything about group of people Running experiments, it might be agents too nowadays. Uh, running experiments cheaply, collaborating, sharing results. Uh, you don't need to understand fully. You, you grab-- you clone somebody else's experiment or somebody else's pipeline, uh, run, uh, change small piece, run it, be, like, get it to production state, and then ship in one click.So then the... You don't have to port it into any other system to, to run in production. You can just run the same experiment. It's, it's fully production ready. And, and it's, uh, it has lots of... Again, as I said, it's third generation system. The original one was, I would claim there was Ether and then, uh, at least in my career, Ether was the first, first, uh, that pioneered this type of approach.And then there was, uh, Nirvana, which, uh, uh, at Yandex, which did kind of sec-second take on this. And now this one aggregates the, the learnings from all of those and, and Airflow as well to, to get to the state where you try it, it, it feels kind of magical. Uh, ‘cause now everything is based on content, uh, hashes.So even if the version changed, but if the output didn't change, nothing is being rerun. It's very efficient. If you... Multiple people start experiment that needs the same sort of data preprocessing, it's not repeated multiple times. It's automatically done only once. If you start ten experiments that all require, you know, some, some data preparation first as the first step, and you don't have to coordinate for that.Like, you don't have to know that other people are starting it. You now, it's very easy compos-, uh, composability, any language you can u- uh, you wanna use, and it's very visual. So you can see immediately, you can edit it easily, you can assemble small things with just even mouse clicks if you want to, and, uh, share, clone.And everybody knows also it's fully kind of static in the sense that we rerun it second time, it will exactly have the same results. Like, you will never have to do digital archeology. So full versioning and everything is also there.[00:24:06] swyx: Uh, so, so people can, uh... It's open source. Go to the GitHub repo and, and, uh, check it out.Uh, and it is also a really good, uh, blog post about it. I think all these is, like, really appealing. The, the, the, the thing that I think sells me the most about it is that, um, sort of development to production transition, right? Which I think, um, a lot of people haven't really solved that, uh, strictly, right?Like, we develop really, really well in, in Python notebooks, but then, you know, that's obviously not a sort of production ready process. I think that, like, any way in which that is solved, I think is, is very appealing. Then the other thing that you mentioned, which also raised my eyebrows, was content-based caching, which you mentioned is, is, um, you know, is ve-very much, uh, um, a sort of efficiency measure about, uh, you know, just like recalculation only on, on sort of content addressing Which I think makes sense.Uh, it surprised me that the savings could be this much, but maybe I just haven't worked at your scale where there's so much duplication, uh, that people just rerun because they change a single ID upstream.[00:25:10] Mikhail Parakhin: It does, yeah. But it's not only you rerun. The, the main savings are coming from the fact that you ran it, you got your job done, and you moved on.Then- Yeah ... somebody else in some department you don't know existed runs the same task, but on a newer version.[00:25:27] swyx: Yeah.[00:25:27] Mikhail Parakhin: Like right now, you can't, in, in most of the organizations, you can't even find out about it so that you can't even measure that you're spending that time twice, right? Here- Yeah ... if everybody's on Tango, that's detected automatically and detected that the output is the same.And then for that person, all it looks like is like experiment just suddenly moved, jumped forward, right? Uh, uh- Yeah ... so that's because, because the, there's network effect of multiple people helping each other.[00:25:51] swyx: Yeah. This is one of those things where it's designed to be a platform from the beginning rather than an individual developer's tool from the beginning, right?And, and everything's gonna streams down from there. That is the sort of Tango, uh, orchestrator, and it's, it manages jobs. We've seen a few versions of this, and this is obviously, uh, uh, the sort of, uh, unique approaches that you guys have, have, uh, figured out. And then there's Tangent.[00:26:14] Mikhail Parakhin: Yeah. And Tangent is basically an automatic auto research loop that can help and kind of do your work for you.Uh- ... you know, uh, effectively, effectively, Andrej Karpathy recently popularized it with auto research. Yes. Remember he said like he was, uh, speed running this, uh... Yeah, uh, you know the story. The, here we're basically bringing the same capability into Tango so that, uh, the, uh, Tangent can analyze it. It's just an agent that can run multiple experiments, figure out what can be changed, and keep on rerunning it, keep on modifying until, uh, maximizing some goal, some loss function, whatever you need to, to achieve.And in general, I would say if you're not using auto research-like approach in whatever you do, like literally whatever you do, then you're missing out. We saw at Shopify that taking like a wildfire, anything where you can put measurements can be done dramatically better. Our-[00:27:19] swyx: Mm-hmm ...[00:27:20] Mikhail Parakhin: uh, speed of, uh, templatization HTML, uh, completely new UX tem- uh, templatization of, uh, reducing latency for liquid themes.Uh, we-- Our, uh, search, uh, recently we moved from It's hard even, uh, quote from eight hundred QPS to forty-two hundred QPS with the same quality just by pure optimizations and not a research loop that kept running and changing code in our index serve on the same number of machines, just increasing the throughput.We, we managed to improve the quality of gisting and machine learning process. Uh, you know, gisting is the prompt compression technique that[00:27:59] swyx: allows for[00:28:00] Mikhail Parakhin: lower latency and, and lower and, uh, actually higher quality slightly. So like literally whatever different walks of life, and it doesn't have to be AI related.Uh, we, we had a reduction in, uh, storage because the agents would go and find data sets that clearly are derivative, uh, and then you don't need to store things twice. You know, we, we, we found somewhat embarrassingly that it was one of the largest tables was hashing random IDs into another random ID, and we literally- Oofput only one. So it was translating, yeah, two random IDs hashed[00:28:36] swyx: into[00:28:37] Mikhail Parakhin: each. So, so[00:28:37] swyx: it has access to the code as well, so it can, it can check the, like what, what the hell is it doing?[00:28:42] Mikhail Parakhin: So there, there cou- it could be run in two levels. You, uh, you know, at the superficial level, it could just use ex-existing components and, uh, reshuffle them.Uh, you know, like you can grab- Yeah ... uh, XGBoost, and you can grab some, some Py- PyTorch module, and then can grab some, you know, grab another tools and, and combine them. At a deeper level, since Tangle is all sort of CLI based underneath you, every, every component is a wrapped really CLI, uh, call and a YAML file, it can analyze code and create new components and, and, uh, keep on iterating as well.So, so you can, you can both have quick modifications of existing t- uh, pipelines with the, with components that are already there pre-baked, or you can create new components, uh, and-[00:29:29] swyx: Yeah ...[00:29:29] Mikhail Parakhin: keep iterating on those. So auto research is, again, this is probably the, the thing I was excited the most in the last two months happening, and we see it taking like, like totally like a wildfire.Just, uh, everybody, every day, every... well, every day, every minute, I would, uh, have somebody Slack message saying, “Oh, look how much better I made it.” And, uh, it's all throughout the research.[00:29:53] swyx: Is this democratized in some way in, in the sense that like is it your ML, uh, engineers and researchers doing this, or is it your regular PMs and software engineers also have the ability to auto-- to use Tangent?[00:30:07] Mikhail Parakhin: This is an awesome question. Like, Tango in general and Tangent in particular are extremely democratizing. Like they- Yeah ... they are the main tools for- ‘Cause I don't[00:30:15] swyx: need the details.[00:30:16] Mikhail Parakhin: Yeah. Exactly. Initially used by ML and AI engineers, but then literally, as you said, PMs are like the highest user right now is one of PMs on our org, uh, Sartak and he was, he was number one by, by usage of, of this ‘cause they're just, uh, energetic and knowledgeable, and now it, it unlocks a lot of capability where you don't have to co-change code manually.[00:30:39] swyx: I mean, I mean, because it kind of cuts out the ML, ML engineer from the process because the, the, the PMs have the domain knowledge and the ability to think about, uh, from first principles about, okay, what, what results do I want? And they can-- they even have the access to the data that, that needs to go in.So it's like in some ways, like this is the magic black box that we've always wanted for, for training and, and for, uh, I guess, uh, uh, hill climbing, whatever.[00:31:04] Mikhail Parakhin: It's basically cloud code for your AI development- ... uh, situation, right? Like now, now you don't have to know exactly how algorithms work. You can just, uh, bring your domain knowledge and expertise and product knowledge and iterate within Tangent until you've gotten the results that you need.[00:31:21] swyx: In my previous roles, every time that someone has pitched AutoML, you know, I've always been like, “Uh, this is not, this is not gonna work. It's, you know, it's, it's always gonna be a flop.” Somehow it's working now. I mean, presumably the answer is now we have LLMs and it's good enough, right? It's, it's an emergent property that we can do auto research, but like, it doesn't feel that satisfying that how come we didn't do this before, right?Like we just did like parameter search and like, I don't know. That's maybe that's it.[00:31:48] Mikhail Parakhin: Yeah. Bayesian optimization and hyperparameter optimization was, was the one that, or facet of AutoML that was used very actively, which incidentally also built into, uh, Tango. But, you know, I know Patrice Simard very well, and, uh, he was such a, uh, such a proponent of AutoML, and he put, like literally spent careers trying to democratize it.Without LLMs, it just turned out to be very hard. Like it, you, you would have flexibility within certain narrow domain, but it was hard to wider scale, and now with LLMs suddenly it's like magic wand, and so suddenly everybody- ... is an AutoML expert.[00:32:28] swyx: Yeah, I, I think it's multiple things, right? Like I'm, I'm just gonna bring up the, the, the chart again, right?Like LLMs can do the monitoring very well. That is the very potentially unbounded, super unstructured. It can do the analysis very well, it can do the... Uh, and basically it is much more intelligence poured into every single step. Uh, there's maybe nothing structurally changed about AutoML, but this is just m-more intelligent and more unstructured.[00:32:53] Mikhail Parakhin: Exactly.[00:32:54] swyx: Any flaws that you've run into? Like everyone is like drinking the Kool-Aid, oh my God, time savings, uh, you know, performance improvements. Like what, what, uh, issues have you have, uh, come up?[00:33:06] Mikhail Parakhin: This is really cool. It's not a solution to all the world's problems for sure. The limitations are usually the ones I-- And this is where we get into a bit of a subjective territory.Uh, I can only share what I've, I've seen so far, and I'm sure the situation, uh, is changing, and, you know, maybe after I say it, like many people will reach out and say, “Hey, what about this?” And you don't know that, and then, then we'll be probably right. But what I've seen is auto research is very good at doing kind of obvious things that you don't have bandwidth to do or you didn't notice or maybe you're not aware of like the-- some standard practices.It is not good at doing something completely out of distribution, something that, you know, you have to think for, for multiple days, uh, and, and do something like none of this. So, so it's, uh, I, uh, set an experiment once, uh, on, on my sort of, uh, hobby thing, and I let it run for, uh, ended up, uh, several weeks run, uh, you know, it's like full production kind of scale, so it, you know, slow runs and, and it ex-- it performed in the end, uh, over four hundred experiments, and only one was successful.I'm like, “Okay, that's, that's good.” But-[00:34:18] swyx: But it saved time.[00:34:19] Mikhail Parakhin: Yeah, I saved time. Like it, it was the, that thing. Yeah, if I, if I were doing four hundred experiments myself, my betting average, as I said, would have been much higher, I'm sure. But also, first of all, it would take me like three years to do four hundred experiments.And, uh, I didn't have to do them. Like the machines were just, uh, the price of electricity did that. So, and I got one improvement, uh, that in, uh, my, my-- Honestly, when I was starting that experiment, my thinking was to go and show that, “Hey, Andre, maybe you just don't know how to optimize.” And I was super smart because in, in my pro-problem, it was optimized for many years, and it was like fully improved.Uh, and I didn't expect it, you know, auto research to find anything at all. Yet it did. So instead of making fun of Andre, I ended up, uh, a big, big supporter. Yeah, that's exactly the tweet. Yes.[00:35:10] swyx: You and Toby really, really go back and forth on-online a lot, which is really funny. Uh, think of it as, as an eval for the optimalness of the code it's running on.Uh, it's almost like it reminds me of like a Kolmogorov complexity thing, but, uh, I guess it's-- there's some optimal thing that you're trying to sort of reduce down to, I guess. Um, and so, so you, you, you know, you should congratulate yourself that you had, uh, you know, uh, ninety-nine percent, uh, optimality.[00:35:36] Mikhail Parakhin: Exactly, yeah. I think Andre really deserves a lot of credit for popularizing this approach. This is, uh, this is incredibly, I think, powerful and cool and You know, the, uh, even him, him just mentioning it led to a lot of gains in a lot of places in the industry, so we should be thankful.[00:35:56] swyx: Yeah. I think he also has a just...I don't know what it is. Like, um, you know, it, it is a simple self-contained project that people can take and apply to other things, which is, is, is one thing, but also just the name. Just like somehow no one, no one managed to call their thing auto research. It's just naming things is very important. I think that that is mostly, uh, our coverage of Tango and, and, uh, Tangents.I think obviously, you know, there's a lot of, uh, ML infra at, at Shopify that people can, uh, dive into. We're about to go into SimGym, but before I do that, any, any other sort of broader comments around this whole effort? Like where is it, where is it leading to?[00:36:36] Mikhail Parakhin: As a segue to SimGym, like all those things start composing strongly.And, uh, you could see a huge unlock when you can look at each one of the tools and, and you see, oh, they're extremely useful. Uh, Tango is useful by itself. Auto Research is useful by itself. SimGym is useful by itself. If you combine all three, you create like synergetic effect. I think that's why we wanted to even, uh, cover them today is because this is something that if you go back even, you know, five years ago, would've been unthinkable.Uh, replicating that, uh, would, would be either incredibly costly or impossible, right? With probably thousands of people are required.[00:37:20] swyx: Well, we have serverless human, uh, serverless intelligence, right? Like, uh, so yes, you do have thousands of hu-- of, of intelligences, not just, not humans. And that's, that's close enough, right?Even if they're not AGI, they're, they're close enough to do the, the task that you need them to do. And, and, you know, that's, there's plenty for, for a lot of routine work, knowledge work. Okay, let's get into SimGym. Um, this is one of those things I, I was surprised to see actually it's apparently your, uh, one of your most popular launches, and I think something that, uh, I think Sim AI, I think Yunjun Park, who did the Smallville thing, there's a very small cottage industry of people trying to do like the simulate customer thing.I think a lot of people maybe don't super trust this yet because they're like, well, obviously they would just do what you prompt them to do, right? But maybe just think, uh, tell us about the sort of inspiration or origin story.[00:38:10] Mikhail Parakhin: That's exactly actually the thing I wanted to cover, because if you don't have the historical data, all you can do is prompt a-agents in a vacuum, and they will do exactly what you prompt them to do.In fact, when I first proposed it, and this is a bit of, um, my brainchild initially, if I, I can boast, even Toby said like, “But wouldn't they, they just repeat what, what you tell them?” And, uh, but I'm like, “Yes, except Shopify has decades of history of how people made changes and what there is, uh, there, what it resulted in terms of sales.”So now what we can do is we can-- we have this... It's not, it's a noisy data. There's a small, usually websites, uh, you know, like things, things are never in isolation. It's almost never AB experiment. It's always AA experiment when there's has two meanings, but basically, you know, in different time you run two different things.But if you aggregate in general, uh, like everything together, and you apply, uh, denoising and collaborative filtering like approach, you can extract a very clear signal. And then you can optimize your agents. And that's why it took so long. It took almost a year of that optimization of just us sitting and fiddling, and, and we had this internal goals of correlation of hitting-- internal goal was to hit zero point seven correlation with, uh, add to cart events, for example.Like that, that if we run real AB test experiment, that it should, it should go and, and rep-uh, replicate, uh, same sort of success that, that humans had or lack thereof. And it, it took forever, and I don't think that's easily replicatable because, uh, like who else would have that data? You have to have this historic, you know, decades, uh, worth of data.And now, now the, like the other thing you need is in-infrastructure and the scale, right? Because, uh, w- again, what we found, uh, stat sig results, you need to run a lot of simulations, a lot of agents, and, and it's-- Those are expensive things. Like you're, you're making actions in the browser because you want a real friction.You want to, to be able to get the image like of what humans will see because you wanna, uh, detect effects like, “Hey, if I make my images larger, will I have more sales or l- uh, fewer sales?” And like usually people's intuition here, by the way, is that I increase my images, I will have more because they look nicer.You know, designers all look sparse and big images. Like usually your sales tank, right? But, but, uh, you know, from HTML, all the characters look the same only the, the size tag looks different, right? So it's very hard. So you have to take visual information, you have to run this in simulated browser environment on the big farm and, and of course, you have to have, uh, like very, very expensive model, good model with multi-model model.So all this it's-- is what's taken so long and, uh, to share my personal fail a little bit there, Sean, is like, you know, we always had this bias to-- for like large company bias. You know, we always, uh, whenever you-- we do, we're like, “Hey, we'll run an experiment,” right? We make, make a change, and we will run an experiment and then, uh, see, uh, see which one's better or like, “No, this is worse,” and most of them are worse, so you discard it and keep iterating, hill climbing.And we're like, “Oh, like smaller merchants, they cannot get stat sig results. They cannot really run experiments simply because, you know, in a week there would be not enough data for them.” So we thought from this perspective. What we didn't realize is that most people don't have A and B, they just have one thing, and they need suggestions of What A and B should be.So, uh, we first build this, hey, we run simulation on two separate teams and, and, uh, say, “Hey, which one is better?” We then morphed it into, and very recently just released it, when you have just your site, your theme, we run over it and we say, “Hey, here's what predicted values of, of, uh, uh, conversions are, and here's how we think you should modify it to increase your conversions.”And then circling back to what you started with, the proof is in the pudding. Like, if we are not correlating with reality, like, people will not be using it. And, uh, thankfully, we see literally every day more users than the previous day. So, so right now, uh, right now- It's working. Yeah. I'm-- Right now my problem is how to pay for it all because the so our major thing is how to optimize the LLMs, do distillation, how to run the headless browsers, uh, and handful browsers, uh, uh, cheaper so that we can accommodate the increase in traffic.[00:42:47] swyx: Yeah. I, I understand that you, uh, you published a lot of technical detail at GTC, so I was just gonna bring it up a little bit. I think s- was this in, in con-conjunction with some kind of GTC presentation? Or something like that, right?[00:42:59] Mikhail Parakhin: Well, we, yeah, we, we did it in several place, but yeah, we had the engineering- Yeahblog, uh, as well. Yeah.[00:43:05] swyx: Yeah. So you're running, uh, GPT OSS. Uh,[00:43:08] Mikhail Parakhin: the, this is an older version. You know, now we run multimodal model. But yeah- Yeah ... GPT OSS, we still run GPT OSS as well for[00:43:15] swyx: And then you have the VMs, and you also have browser-based. I really like this one where it you said, “It violates almost every assumption that standard LLM serving is designed for.”And then you had like, basically orders of magnitude differences between everything.[00:43:29] Mikhail Parakhin: Exactly. Which is, which, uh, which was, you know, a bit of a challenge to implement, like when, like even simple things. Uh, be- since it violates all the assumptions, for example, multi-instance GPUs, like MIGs don't work as well.But we needed, uh, to get MIG to work because, ‘cause otherwise it's way too expensive. And so we had to deal with the, yeah, with, uh, lots of infrastructure and, and, uh, work with, uh, uh, Fireworks and CentML, uh, you know, to help with optimizations and browser-based, as you mentioned. Yeah, like, takes a village.[00:44:04] swyx: Okay. So there's a lot of like, I guess, experimentation in the infrastructure so far, and you've published more or less what you have here. I guess I'm, I'm less familiar with CentML. I, I don't do, uh, that much work in this, this part of the stack. But why was it the sort of preferred instance platform?[00:44:22] Mikhail Parakhin: There are really three probably top companies. There used to be, uh, uh- Three top companies, uh, at least I was aware of that did, uh, LM optimization. You know, together Fireworks and Santa ML, not necessarily in that order. Santa ML recently got acquired by NVIDIA. Uh, what they did is if you have a model and you want to optimize it to a specific prof-- uh, profile of usage, uh, they would go and do it.And, uh, we work with, with those companies, uh, this was work particularly in with Santa ML and NVIDIA to get them the best possible results out of it. And, and sometimes you, you have to retune depending on, like sometimes you want the maximum throughput, sometimes you want minimal latency, sometimes you want like the cheapest, right?And, yeah, or some combination. And so yeah, these are people who would come and help you.[00:45:14] swyx: I see. I see. Yeah, yeah. I'm familiar with these people for the LLM, you know, autoregressive stack. But the other interesting category of these optimizers is also the diffusion people, whereas like Fel and, you know, uh, Pruna recently has come up a lot as well, which I think is like really underappreciated, uh, at least by myself, because I, I thought, oh, all the workload would be LLMs, but actually there's a lot of diffusion as well.[00:45:38] Mikhail Parakhin: Exactly.[00:45:38] swyx: There's a lot here, so I, I, I... it's, it's, uh, it's, it's, it's hard to cover. But I, I do think like people underappreciate the importance of customer simulation, basically. I think this is something that I'm candidly still getting to terms with. Uh, you know, uh, you also-- your team also like prepared this, like, really nice diagram.Uh, I, I assume this is AI generated.[00:46:00] Mikhail Parakhin: Yeah, it looks-[00:46:01] swyx: Maybe it's not.[00:46:01] Mikhail Parakhin: Yeah, it looks, uh, Gemini-ish. Yeah, but, uh, uh, honestly, I, I don't know where, where the hell they generated. It looks, look, uh, looks like it's, uh, Google. But the interesting part, John, that, that, uh, we haven't covered, but I, I wanted to mention is if your store had previous customers, rather than it's a new store, you're like new merchant just launching things, it helps tremendously in just correlation and forecast.Yeah, we take your previous, uh, customer's behavior, and we create agents that replicate those specific distribution of, of customers that you get, and then we a- we apply those to your changes, and then that, that raised raw, you know, the re-- uh, just correlation with the add to cart events or to-- with conversion or whatever it, it, it may be, uh, quite dramatically.So, uh, replicating humans in general seems like an interesting, cool challenge.[00:46:58] swyx: As a shareholder, I think this is the-- like if people are Shopify shareholders, they should really deeply understand this because this is basically the moat. The, the more you use Shopify, the more it will just automatically improve, right?Like you're, you're doing the job for them.[00:47:13] Mikhail Parakhin: Yeah, that's what we started with. Like, uh- ... uh, otherwise, if you're just a startup, I wouldn't do it if, uh, you know, if it was my startup because Without the data, it, yeah, as, as you said, it's, it's exactly the case that, uh, whatever you say in prompt, that's, that's what the agents will be doing.[00:47:30] swyx: The statistician in me wants to like really satisfy the sort of, um, statistical intuition, I guess. Um, to me it's kind of, uh, the, the word that comes to mind is, um, ergodicity. Uh, so let's say a, a customer takes this path, customer takes this path, customer takes this path, right? Um, the... In my mind, the way I explain it is like, okay, here, here's the ninety-five percentile, here's the five percentile, and here's the median, right?Um, but to me, what SimGym is potentially doing is that it can, uh, modify... It can sort of model the sort of in-between sort of journeys as well, that, that maybe are dependent on the previous states. This may be like a very RL-type conclusion where like basically the summary statistics, if you only did naive AB testing, you only have the, the statistics at, at, at a certain point, and you only judge based on the sort of overall summary statistics.But here you can actually model trajectories. Does that make sense? Or-[00:48:31] Mikhail Parakhin: That makes total sense because like, well, that, that makes even more sense that maybe even you realize bec- because-[00:48:38] swyx: Okay. Please,[00:48:38] Mikhail Parakhin: please. Yes ... we do-- Yeah. The, so internally, uh, we have this system, we talked about it briefly once at NeurIPS.We have a huge HSTU-based system that models the whole companies, uh, and their possible paths. And like- Yeah ... what you are, what you are showing, like actually at any point of time, you can either model the user's behavior or you mo- can also think about, uh, the whole merchant as a company, as the entity that acts in the world.You can model that as well. And then you can do, can do counterfactuals. In your graph, like in your blue graph, uh, if you're... Imagine in the center there, uh, somewhere in the middle, you would have an intervention. I give that person a coupon, or I don't know, I send a personal thank you card, or give a discount in some- somewhere.And then you can, uh, then you can do forward rollouts from that counterfactual. So what would have happened with that intervention or without the intervention? And you can even ch- change where that intervention, uh, in time can happen, right? Like some- where, where in this journey. So we, we do this at the Shopify scale for our merchants, and then if we notice that something that they can be fixing, like there's a strong counterfactual, like we have Shopify policy, they basically get a notification like, “Hey, we think your...something is wrong with your-” I don't know, Canadian sales. Like, uh, it looks like it's misconfigured. Here's what you need to do. Or do you think like, uh, you have to set up this campaign with these parameters? And we do that at the buyer level to literally offer discounts or cashback or, or things to buyers.So this is-- I'm getting very excited. Like this is my sort of area of, uh, interest, I guess, and, and hobby. But being able to m-model something complex as human beings or companies and model counterfactuals on it, where you can have interventions in the future and optimize when to make intervention, what kind inter-- uh, what kind of intervention to make.It's such an unlock that previously was completely impossible. Like the-- it was, it was always dreamed of, but never... Like how would you even simulate it without LLMs or HTUs? I think very, very exciting times.[00:50:59] swyx: I just wanted to, uh, to maybe illustrate this. I, I'm not the best illustrator, but I, I am a conceptual statistics guy.And y-you know, you cannot just do this. Like this is a dimensionality AB test doesn't do, right? Like, uh, because it doesn't have the, the, the change over time, uh, stochastic nature, uh, and it doesn't have the sort of contextual like... Here's all the context to this point. Um, okay, cool. Um, that's SimGym.You're, you're gonna burn a lot of tokens on this thing. But you're, you're one of the, the only scale platforms in the world that can, uh, that can do this across a huge variety of workloads, right? I'm even curious on a sort of human, uh, research level of like, well, do, does retail behave d-differently from like clothing sales?D-does that behave differently from electronic sales? I, I don't know. I don't know what else you guys... The Kardashian shoppers, do they differ from like people who buy, uh, I don't know, cars and, uh, whatever.[00:51:55] Mikhail Parakhin: Well, very different, and different sensitivities and different modes of, uh, shopping and, and different levels of what's important.Now, to-totally, you can do aggregations at, uh, at a store level. You can do aggregations at a different, uh, category level. I don't know if, uh, you know, for our statisticians among us, I couldn't believe, but we-- recently we're looking at it, and we had to bring back, uh, CRPs, you know, Chinese restaurant process.It's a, like, way of aggregating and, like, naturally grow clustering. So across... Specifically to answer questions that, uh, like you were just posing on how, how if, if buyers behave different categories. And I'm like, “I haven't seen CRP since two thousand and one.” It's[00:52:37] swyx: so What? It's so- What is... No, I haven't, I haven't seen this.No. This is not in my training. Uh,[00:52:44] Mikhail Parakhin: but, but yeah, it, uh, uh, it actually, like the, the-- there was a very popular kind of theory, popular neurips HTML circles in early two thousands, uh, kind of nice. And now, now it has practical applications, uh- Yeah ... that we were resurrecting.[00:53:03] swyx: Yeah, amazing. Uh, I, I can see, I can see how this is like a, uh, a fun job for you where you get to apply all these things.Um, yeah, yeah, so super cool. Super cool. So, okay, so, so anyone who, who knows what CRPs are and has always wanted to use them at work, uh, they should, they should definitely join Shopify. Okay, so w-we have a lot and but I, I'm, I'm being mindful of the time. I, I do wanted to, to sort of cover some other things.Um, I-I'll give you a choice, UCP or Liquid?[00:53:30] Mikhail Parakhin: Liquid. I think, I think on UCP, you know, like UCP is very important for us and, and it just we are-- UCP, we have a structured, uh, discussions, and you can read about them, and we have, uh, blog posts, and we have a big release this week, in fact, like with our catalog.Oh,[00:53:46] swyx: okay.[00:53:46] Mikhail Parakhin: Uh, yeah,[00:53:46] swyx: but- Le-I mean, we, we can, we can discuss the, the, the release briefly because we'll release this after the-- after it's already announced so whatever. There's a catalog that you guys are doing?[00:53:55] Mikhail Parakhin: Yeah. So we are, we are- Okay ... we are bringing in capabilities of a whole, uh, Shopify catalog.Basically, you now you can search for products, you can do lookups by specific ID, you can do bulk lookups when you need to bring m-multiple products. You don't need to know in ad-in advance what you're trying to show or to sell or check out. Like, you can now, you can now have this decided at, at runtime, and this big area for investment for us for both non-personalized and personalized searches, trying to provide basically a win-window into whole universe of products that are being sold everywhere in the world.And Shopify is really not exactly, but almost like a super set of any-anything being sold. Now we are bringing it into UCP and, uh, and, uh, identity linking is another big thing for us, uh, so that you, you can use, uh, like Google or whatever, whatever identity you have, uh, they're minimizing friction.[00:54:56] swyx: Yeah. So[00:54:57] Mikhail Parakhin: yeah, big release for us.But Liquid AI of course we never talk about, and the problem might be more, more aligned with what we d-discussed previously on this chat.[00:55:07] swyx: Sure. The main thing that everyone understands about Liquid is that it is inspired by Worm, and I still don't know why. I'm curious on your explanation. I think you, you, uh, you can make things very approachable.And also I think like what is the potential of like the, the level of efficiency that you get out of Liquid?[00:55:23] Mikhail Parakhin: You- we all familiar with transformer architectures. And, uh, for the longest time, there was a competing architecture, it's called the state space models. So, so Sams, uh, you know, Chris, Chris Reyes, one of the pioneers and, and lots of startups, uh, trying to make those realities.They have, uh, significant benefits being main being, uh, being much faster and, uh, lower footprint and not quadratic in length, you know, sort of, uh, linear in, in, uh, in your context length. But with state space models- They never quite made it. Like they're used-- They have, uh, certain niches when they thrive, their hybrid architectures are useful, but they never quite made it.And liquid neural networks are, you can think of them as a next step, like, uh, sort of, uh, state-space model square. It's non-transformer architecture that's more complicated than sta-state space and really difficult to code if you-- if I'm being honest. But it's, um, very efficient. It's, uh, subline-- sub, uh, quadratic in, in length of your context.Uh, it's very compact way to represent things, and that's a liquid AI company. They... Their goal is to productize it, and very often you have this need, uh, when you need to have long context and small model, and you want to have low latency. Like in general, it's basically on par with transformers, and if you do hybrids with transformers, it's, it's even better.That's why we at Shopify, when we tried multiple and we constantly try multiple models, multiple companies, we found that for small, particularly with low latency applications, when you have low latency and/or if you need longer context lengths, liquid was the best. And so we still use the whole zoo and always like obviously test and use everything, uh, every open source model and, you know, it feels l

Part of the 'New Testament Survey' series which gives an overview and themes of the books of Jude and Revelation followed by some sermon outlines. #NewTestamentsurvey #Revelation #Babylon #Christ #Millennium #Sermon #judgement #fall #visions #towerofBabel #opposition #Godspeople #enmity #enemy #beast #seven #worldlygovernments #earthlyrulers #defeating #churchage #symbolic #Allthingsnew #newheavens #newearth #bride #newJerusalem #eternity #Genesis11v1-9 #Luke11v21-22 #1John2v15-17 #Revelation17v1-22:21 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

In this episode, recorded in February 2026, GBM's Head of Communications Paul Brunning chats to Calix & Bea Furus who are preparing to go to Madeira to serve alongside Christ's Church Funchal. Their particular focus will be to develop ministry among the Spanish speakers on the island.   An 8-minute video edit of this interview will be featured as our Prayer Waves episode for April 2026.

Introduction In this episode of the Insurtech Leadership Podcast, host Josh Hollander welcomes back Jessica Leong, co-founder of Octagram Analytics, to discuss FireRQ — a non-catastrophe fire risk model delivering actionable risk scores for any U.S. address. While the industry fixates on headline-grabbing catastrophes, Jessica and her team are tackling the everyday fire risk that quietly drives loss ratios, underwriting decisions, and portfolio performance. Guest Bio Jessica Leong is co-founder of Octagram Analytics, an actuarial analytics firm. Before founding Octagram, she served as Head of Data & Analytics at Zurich North America, where she led the team that built all predictive models for pricing and claims. She is also a former President of the Casualty Actuarial Society. Jessica brings over a decade of experience in insurance predictive analytics to the problem of non-catastrophe fire risk. Key Topics Non-cat fire risk: the overlooked loss driver — Fire (excluding wildfire) accounts for 15–30 points of property loss ratio in homeowners and commercial lines, yet most carriers treat it as a solved problem. Jessica explains why it isn't. The dataset advantage: 1.7 million fires — Octagram built FireRQ on the National Fire Incident Reporting System (NFIRS), a publicly available dataset of fires reported by U.S. fire departments. Even Fortune 500 carriers only see ~1% of this data in their own books. Repeat fires and fire clusters — The data reveals that buildings with prior fires are significantly more likely to burn again, and that fires cluster by geography and occupancy type. The Myrtle Beach hotel cluster (10–15 hotel fires per year in a single zip code) is a striking example. Machine learning for fire prediction — FireRQ uses a gradient boosting machine (GBM) that starts with building-level history, then branches outward to area and occupancy-level fire experience. The model captures 80% of fires in the worst 20% of buildings. How underwriters use FireRQ — Carriers apply the score for pricing adjustments, risk selection (declining high-score accounts), and early warning. Octagram offers a free proof of concept using an older model version so clients can validate on their own loss data. Model transparency and explainability — As larger accounts adopt FireRQ, demand for "why" behind scores is growing. Octagram is adding context layers: prior fires at the location, area-level fire frequency, occupancy benchmarks. What's next for Octagram — LiabilityRQ and CrashRQ are in development, extending the same data-driven approach to liability and auto crash risk. Quotes "We can look at 100% of the data where you're staring at 1% of the data." "If we tell you these buildings are the worst 20% buildings in the U.S., we do see they have 80% of the fires." "No one talks about [non-cat fire] anymore, but it's still a very, very real risk." Resources Octagram Analytics website: octogramanalytics.com The Little Book of Fires: Free resource available on the Octagram Analytics website National Fire Incident Reporting System (NFIRS): Publicly available U.S. fire data Subscribe & Review If you enjoyed this episode, subscribe to the Insurtech Leadership Podcast on YouTube, Apple Podcasts, Spotify, or wherever you listen. Leave a review — it helps other insurance and technology professionals find the show.

Part of the 'New Testament Survey' series which gives an overview and themes of the books of Jude and Revelation followed by some sermon outlines. #NewTestamentsurvey #Revelation #visions #spiritualconflict #Christ #dayofjudgement #woman #rule #rodofiron #dragon #Satan #protected #God #worldgovernments #opposition #persecution #falsereligions #144000 #angels #sevenbowls #wrath #seventrumpets #Daniel7 #Revelation12v1-16v21           Occasional series in which answers to listeners' questions are shared as part of the Serving Today radio programme. #answeringlistenersquestions #Cain #incest #marriage #genetics #shame #family #wife #Genesis4v16-17 #Genesis5v4 #Leviticus20v17 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk Music: Forest Walk by Alexander Nakarada (CreatorChords) | https://creatorchords.com Music promoted by https://www.free-stock-music.com Creative Commons / Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Part of the 'New Testament Survey' series which gives an overview and themes of the books of Jude and Revelation followed by some sermon outlines. ‘The overall message of the book which is the ultimate victory of Christ and his church over Satan and all the forces of evil.' #NewTestamentsurvey #Revelation #visions #sevenseals #trumpets #lastjudgement #churches #churchage #throneofGod #heaven #worship #sovereignreign #Christ #thelamb #whitehorse #Gospel #suffering #persecution #opposition #martyredsouls #wrath #holyGod #warning #plagues #troubles #Satan #Revelation4v1-11v19 A pastor talks to his people from the Bible about different issues that many of them face. #Pastoral #Pastor #speak #care #mouth #words #tongue #Proverbs10v19-21 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

Part of the 'New Testament Survey' series which gives an overview and themes of the books of Jude and Revelation followed by some sermon outlines. #NewTestamentsurvey #letters #sevenchurches #comfort #churchage #goldenlampstands #John #Jesus #divineauthority #majesty #pastors #authority #death #encouragement #rebuke #vision #faithful #commendation #condemnation #promise #blessing #exhortation #Revelation1-3 A pastor talks to his people from the Bible about different issues that many of them face. ‘We need to get to know the word of God so we can get to know the God of the word.' #Pastoral #Pastor #Godsword #theBible #honours #godlywisdom #heart #reflect #Psalm119v9-11 #Luke11v28 #James1v22-25 For more audio from GBM, visit www.gbm.org.uk/listen To contact us, please email servingtoday@gbm.org.uk

The following article of the Finance & Fintech industry is: “Investment Strategy 2026: Lessons from F1 and Elite Sports” by Luis Felipe Madrigal Mier y Terán, Director GBM Advisors, GBM. (AA1708)

In this powerful episode of Game Over: c*ncer, hosts Dana Nichols and Val Solomon sit down with pediatric cancer survivor Tayler Ellison to hear a story of extraordinary resilience.Tayler was first diagnosed with glioblastoma (GBM) at just four years old, later faced osteosarcoma at 13, and then battled a second osteosarcoma during her first year of college. Now 21 years old and currently in remission, Tayler shares how cancer has shaped her life across childhood, adolescence, and early adulthood.Through the powerful visual of her Beads of Courage, Tayler walks us through the realities of pediatric cancer treatment: countless hospital stays, chemotherapy treatments, surgeries, therapies, and the lifelong effects survivors carry.Despite facing cancer three times, Tayler continues to pursue a future in medicine. She is currently studying biology on the pre-med track at the University of South Florida and works as an anesthesiology technician at Johns Hopkins All Children's Hospital, the same hospital where she received treatment.This episode explores the realities of survivorship, the long-term impact of pediatric cancer, and the relentless courage it takes to keep moving forward.If you've ever wondered what pediatric cancer survivorship truly looks like, Tayler's story will stay with you.----------------------------------Connect with Dana: https://www.linkedin.com/in/danaknichols/Connect with Val: https://www.linkedin.com/in/valerie-solomon/Upcoming Ckc Events: https://cannonballkidscancer.org/category/make-an-impact/events/----------------------------------Podcast Produced by Hi Hello Labs: Website: https://www.hihellolabs.com/

Pablo Limón es asesor financiero, coach, terapeuta y facilitador de círculos de hombres. Es ingeniero industrial por el ITAM y fue Managing Director en GBM, donde asesoró a fondos e instituciones globales. Se ha formado en herramientas como Internal Family Systems, Somatic Experiencing, 5 Leyes Biológicas, The Work de Byron Katie, Teoría Polivagal y Constelaciones Familiares. Hoy acompaña a CEOs, founders y dueños de empresas a integrar el bienestar personal con el éxito profesional.  En este episodio converso con Pablo sobre lo que hay detrás del éxito profesional cuando el hacer se convierte en la única forma de sentirse suficiente. Partimos de su decisión de volverse más público después de años de mantenerse en la privacidad, y entramos en las historias no integradas, la rigidez, la disciplina y el molde que lo formó y el costo emocional que eso tuvo. Hablamos del sistema nervioso, de cómo el cuerpo guarda memorias que el lenguaje no alcanza, y de cómo esta comprensión está transformando su manera de trabajar con CEOs y empresarios: si las empresas son un reflejo del estado fisiológico de sus líderes, entonces la transformación no empieza en la estrategia, sino en la raíz. Cerramos hablando de círculos de hombres, de espacios seguros y de lo que significa, a los cuarenta, dejar de vivir para cumplir expectativas y empezar a contar la propia historia.

Send us Fan MailPaper Discussed in this AI Journal Club:Artificial Intelligence-Based Digital Image Analysis for Assessing Ki67, P53, and PHH3 Expression in Glioblastoma Multiforme. Devrim T, Erkilinc G, Tuncer SS. J Coll Physicians Surg Pak 2026; 36(02):153-157Episode Summary: In this journal club deep dive, we step out of the theoretical future of AI and look at a direct, hard-data showdown between artificial intelligence and the human eye. We examine a groundbreaking 2026 study on Glioblastoma Multiforme (GBM) that forces us to ask an uncomfortable question: What happens when the AI and the human completely disagree? And more importantly, is it possible that the AI is detecting a biological reality that experienced human pathologists are entirely missing?In This Episode, We Cover:• The "Boss Battle" of Neuro-Oncology: Understanding Glioblastoma Multiforme (GBM), the most aggressive primary brain tumor in adults, and why precise prognosis dictates the entire treatment strategy.• The Big Three Biomarkers (The Speedometer, The Brakes, and The Neon Sign):    ◦ Ki67: The "speedometer" of the tumor, marking active cell proliferation.    ◦ p53: The "guardian of the genome," acting as the emergency brakes for damaged cells. In GBM, these brakes are often broken or mutated.    ◦ PHH3: A specific "neon mitosis tracker" that lights up dividing cells, offering a cleaner alternative to traditional manual counting.• The Showdown - Humans vs. AI: Two experienced pathologists go head-to-head with an AI digital image analysis system (QuantCentre module by 3DHISTECH) on 20 adult GBM cases, looking at both 1 mm² and 7 mm² tumor hotspots.• Round 1 - The Shocking Lack of Concordance: The AI and human pathologists had practically zero statistical agreement (Cohen's Kappa) on the raw numbers. The human eye acts interpretively, filtering out background noise, while the AI calculates literal pixel intensity.• Round 2 - The AI's "Aha!" Moment: Biologically, a high proliferation rate (Ki67) must correlate with high mitosis (PHH3). Human pathologists failed to find any statistically significant link between these markers. The AI, however, found strong, biologically accurate correlations between Ki67 and PHH3, and between PHH3 and p53.• The Future of the Lab: Why AI shouldn't replace pathologists, but rather serve as a hyper-sensitive tool to uncover hidden data patterns and personalize medicine. We also discuss the major roadblock preventing immediate clinical rollout: color standardization and image quality.Key Takeaway: The lack of agreement between humans and machines doesn't mean the AI is wrong. By successfully identifying crucial biological relationships that humans missed due to attentional fatigue and subjectivity, the AI proved its data might actually be closer to the biological truth than our current gold standard.Question of the Week for Our Trailblazers: Should we stop asking if the AI is as good as the human, and start asking if the human is actually precise enough to judge the AI? Let us know your thoughts!Support the showGet the "Digital Pathology 101" FREE E-book and join us!

3 NYC native old heads try to set a young buck straight in front of his lesbian caretaker. Angry Derek and a juiced up Geo are joined by Chris from Brooklyn and GaS lovers producer Nat and GBM to discuss celebrations of February, Epstein's newly released shenanigans, health insurance, Derek's aging, fitness and diet tips for twinks, the death of podcasting and so much more.ON THE GATE! ENJOY!Original air date: 2.9.26Join the live chat Wednesday nights at 11pm EST. Uncensored versions of the show streamed Monday and Thursday at 2pm EST on GaSDigital.com. Signup with code OTG for the archive of the show and others like Legion of Skanks, In Godfrey We Trust, and Story Warz. FOLLOWGeo PerezInstagram - https://www.instagram.com/geoperez86/Derek DrescherInstagram - https://www.instagram.com/derekdrescher/On The Gate! A podcast hosted by two jailbird/recovering drug addicts and active comedians Geo Perez and Derek Drescher, who talk each week about their times in jail, what they learned, what you should know, and how they are improving their life or slipping into recidivism each day!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Welcome, almost, to a new year of The Christian's Hour! TCH is a ministry of Gospel Broadcasting Mission. GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.We hope you had a Joyus Christmas, and we hope this New Year brings you and your family more blessings in Christ than you can count! Have a Happy New Year.This Christmas season, Ben Cachiaras, the lead minister with Mountain Christian Church in Joppa, Maryland, has been helping us look past the “rif-raf” of the world's version of the Holidays and the Christmas tree to see the really big picture, of the Hope Christmas represents, in this series Ben calls “Don't Miss the Forest for the Tree”. As we prepare for the new year, what better way than to begin with a new perspective, new hopes, new resolutions. Kinda like a “do over”. So what is more fitting than talking about Planting A-new, kinda like planting a new tree? In today's message: “Planting Trees” Ben continues looks at the forest from the perspective of planting something new, a new start, so to speak, Here's Ben To support this ministry financially, visit: https://www.oneplace.com/donate/326/29?v=20251111

TCH is a ministry of Gospel Broadcasting Mission.GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.For most people of our culture Christmas has become so familiar; most people miss the point. Beyond the decorations and gifts in front of us, there is a much bigger story to notice ' a vast forest of wonder and meaning for everyone.This Christmas season, Ben Cachiaras, the lead minister with Mountain Christian Church in Joppa, Maryland, is helping us look past the “rif-raf” of the world's version of the Holidays and the tree to see the really big picture, of the Hope Christmas represents, in this series Ben calls “Don't Miss the Forest for the Tree”.Years ago, I cut down a diseased tree in our front yard. I thought it was case closed. The tree, however, had other thoughts and out of that stump grew a shoot, then another and another. Today we have a beautiful… “bush”. In today's message, “Hope from the Tree Stump”, Ben shares how Jesus' birth is God making good on a promise of hope from a different kind of stump… for all of us… To support this ministry financially, visit: https://www.oneplace.com/donate/326/29?v=20251111

Welcome to the TCH broadcast! TCH is a ministry of Gospel Broadcasting Mission.GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.There is a lot of history, a lot of meaning behind the Christmas Tree. Some would say it is pagan in its origins, others give it meaning that goes back to the original sin. But there is a danger in getting caught up in the world's version of the Christmas Tree and missing the real meaning of Christmas.This Christmas season, Ben Cachiaras, the lead minister with Mountain Christian Church in Joppa, Maryland, is helping us look past the “rif-raf” of the world's version of Christmas to see the really big picture of what Christmas represents in a series Ben calls “Don't Miss the Forest for the Tree”.Imagine with me, for a moment… in the middle of the most perfect garden you can imagine; a tree. This is no ordinary tree, it is the tree of life, eternal life. Now, imagine again, that tree made new, this time near the throne of the eternal, creator God. You know, you and I, we live in a space between those two trees. Got your attention? Here's Ben to explain… To support this ministry financially, visit: https://www.oneplace.com/donate/326/29?v=20251111

The blood-brain barrier (BBB), while essential for protecting the brain from toxins, has long been one of the greatest obstacles in treating brain diseases, particularly aggressive cancers like glioblastoma. Most chemotherapy drugs simply cannot reach the brain in effective concentrations, leaving patients with limited treatment options and poor outcomes.  In this episode of Curing with Sound, we speak with Graeme Woodworth, MD, Chair of the Department of Neurosurgery at the University of Maryland School of Medicine, whose work is transforming the landscape of brain tumor treatment through the use of focused ultrasound–mediated BBB opening. Dr. Woodworth discusses the role of microbubbles, his efforts to develop a real-time monitoring and dosing strategy for BBB opening, and the exciting results from his multicenter glioblastoma clinical trial. Discussion highlights: Glioblastoma Clinical Trial: Results published in Lancet Oncology report, for the first time, a possible survival benefit among newly diagnosed glioblastoma (GBM) patients treated with focused ultrasound + temozolomide (or TMZ, a chemotherapy drug). Researchers used focused ultrasound to noninvasively open the BBB in GBM patients before administering TMZ. When compared with a matched control group, a 40% increase in overall survival was observed. Published Findings for Measuring and Predicting BBB Opening: Researchers established a real-time, ultrasound-based “dose” measurement—using acoustic emissions from microbubble oscillations—to accurately predict when focused ultrasound will open the blood-brain barrier in glioblastoma patients. They discovered a non-linear dose–response range where blood-brain barrier opening is maximized, enabling safer, more precise, and more effective treatment monitoring. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.  Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.  FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

Welcome to the Christian's Hour Program, Thanks for joining us! TCH is a ministry of Gospel Broadcasting Mission. GBM's mission is to broadcast the message of Jesus, in their heart's language, to unreached people groups and tribes world-wide.This week we celebrate Thanksgiving, a National Holiday since 1863, that traces its origins to the Pilgrims in 1621. Thanksgiving's origins came out of a deep-rooted sense of gratitude to God. These days it almost seems the Holiday is tied more to family gatherings and meals, and giving thanks is secondary. Maybe it's time for a “course correction” to get back to our roots of giving thanks, to God?!This month, Bob Russell, is helping us with an “Thanksgiving Season - Heart Check” in preparation for a more meaningful Thanksgiving. Bob Russell is a retired senior minister of Southeast Christian Church in Louisville, Kentucky, where he served for 40 years as “Southeast” became one of the largest churches in America. There is an old proverb that says “you reap what you sow”. In today's message, “An Attitude of Gratitude” Bob has 5 ways we can sow an attitude that can help us transform our personalities into someone who radiates Thanksgiving. Here's Bob to talk more than turkey! To support this ministry financially, visit: https://www.oneplace.com/donate/326/29?v=20251111

TCH is a ministry of Gospel Broadcasting Mission.GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.Thanksgiving, a National Holiday since 1863, it is said it traces its origins to the Pilgrims in 1621, and it came out of a deep-rooted sense of gratitude to God; and that gratitude was much more than a one day, one meal sort of thing. Today, it can seem the Holiday is tied more to family gatherings and meals and giving thanks is secondary. Maybe it's time for a “course correction” to get back to our roots of giving thanks, to God?!This month, Bob Russell, is helping us with an “Thanksgiving Season - Heart Check” in preparation for a more meaningful Thanksgiving. Bob Russell is a retired senior minister of Southeast Christian Church in Louisville, Kentucky, where he served for 40 years as “Southeast” became one of the largest churches in America. Stuff… the world advertises it, constantly, our family, friends, neighbors flaunt it, our culture idolizes it. You know, accumulating stuff, doing stuff, going to see stuff. Problem is, at its best, stuff is still only temporary and more-over its really not fulfilling in the long term. So, here's Bob to help us laser in on what's really real… To support this ministry financially, visit: https://www.oneplace.com/donate/326/29?v=20251111

Send us a textIn this episode, Abraham Gonzales shares his journey through two unimaginable tragedies: losing his wife, Mari, to GBM and surviving the Robb Elementary School tragedy. His story is one of caregiving, heartbreak, and remarkable resilience.Content warning: This episode includes discussion of grief, loss, and traumatic events that may be difficult for some listeners. Please listen with care.Support the showRare Enough is a podcast powered by Head for the Cure, sharing real stories of resilience, hope, and community from those facing brain tumors and the people who walk beside them. Subscribe, listen, and share, because every story matters, and no one should face brain cancer alone. Follow on Instagram @RareEnoughPodcast Learn more at BrainsfortheCure.org

SOCA THERAPY - NOVEMBER 2, 2025Soca Therapy PlaylistSunday November 2nd 2025Making You Wine from 6-9pm on Flow 98.7fm TorontoDifferentology (Dr. Jay Plate) - Bunji GarlinMy Home - Preedy x Jaiga x Dj SpiderMas Band Thoughts - Ding Dong x Dj SpiderThis Moment - GBM Nutron x Skinny FabulousJudgemental - LyrikalBody Tea - Adam OPieces - Nadia BatsonSymphony - Keshav x Dj Private RyanConquer You - Anika Berry x Dj SpiderLow Key - Blaka DanToo Own Way - VoiceYoung and Restless - VoiceNot Normal - Problem ChildHot Foot - Shal MarshallSweet Spot - Patrice RobertsRecipe - Imani Ray x PumpaHorning - This Is Kash x Miguel MaestreGo Down - D1Property - Added Rankin x Rich RastaPush It - Lil’ BittsCarnival Traffic - Skinny Banton x I-OctaneBumpa - MelickSpoil Myself - Avi Da ArtisteSpoil Mehself - Kerwin Du BoisState Of Mind - DestraTrue Masquerader - Kes The BandShe Coming - Machel MontanoDo Wah Yuh Want (Jime & Quixx Chant Intro) - Tian WinterTOP 7 COUNTDOWN - Powered By The Soca SourceTop Songs By Anika Berry Streamed On Spotify7. Reign - Anika Berry x Pahjo x K-Lee x Shakerhd Productions6. Freedom - Anika Berry5. Undefeated - Anika Berry4. Waistline Distraction - Anika Berry x Turner3. Ginger - Anika Berry2. Saddle - Anika Berry1. Jamming - Anika BerryBest Fete - Anika BerryMr. Fete - Machel MontanoSingle - Orlando OctaveJammin’ Sake - LyrikalWine For Meh - VigilanteCall Meh - OlatunjiRude Gyal - Kimba SorzanoIn Charge - Machel MontanoWe Time - JW & BlazeBubble On Ah DJ - SwappiJab Jab Nation - TallpreeTombstone - Mandella LinkzGrease It Down - Socallective x Dred LionViral Again - L.E.DPayroll - MuddyCapital Anthem - Capital Jab1000 Degrees - Bubbah473Jab Decisions - V'ghn x Terra D GovernorPAN MOMENTSDe Pan Man Riddim - Joshua Regrello x BadJohn RepublicStreet Party (De Pan Man Riddim) - Runi JayBun Dem Out (De Pan Man Riddim) - King JamesTANTY TUNE(1983) Swing - Super BlueNORTHERN PRESCRIPTIONFor Christmas - Miguel MaestreLiming Spirit - Shal MarshallFunday - Shal MarshallBig Truck - Imani RayCheers - Problem ChildWedding Band - Coutain x TanoParty Bag - Anika BerrySweet Music - Voice x Trini BabyOuu La La - Trini BabyPermission - Jadel x GBMCastaway - Full BlownKaya - Freetown CollectiveDey For You - Marq PierreLast Train - Mical TejaGimme Wuk Darlin - SucreBuss A Wine - Fay Ann x Bunji GarlinFollow Dr. Jay @socaprince​ and @socatherapy“Like” Dr. Jay on http://facebook.com/DrJayOnline

TCH is a ministry of Gospel Broadcasting Mission.GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.So, for most of us, we have probably not pictured Jesus as a freedom fighter.But truth is, He was, in fact He liberated people from the powers of darkness so they could become who they were created to be.What was true then, is still relevant today! All this past month, Rick Atchley, Senior Minister with The Hills Church in Fort Worth Texas has been exploring what that liberation looks like in his series; “No Longer Slaves”.So, if Jesus is our rabbi, we need to be just as committed to His ministry of helping people claim “no longer slaves” status. In today's message: No Longer Slaves to the Futility of Mission Rick explores how our most fulfilling purpose for life can only be staying aligned with the assignment Jesus, our rabbi, has given us. Curious? Here's Rick to unpack what living with intent can mean. To support this ministry financially, visit: https://www.oneplace.com/donate/326/29

This is the Christian's Hour Broadcast. TCH is a ministry of Gospel Broadcasting Mission. GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.I don't know about you, but my first thought of Jesus is not usually that of a freedom fighter. But truth is, He has, and continues to liberate people from the powers of darkness so we can become who we have been created to be.This month, Rick Atchley, Senior Minister with The Hills Church in Fort Worth Texas is exploring what that liberation looks like in this month's series; “No Longer Slaves”.This time of year, there is a lot of lightheartedness surrounding the Devil and his surrounding darkness. However, the Bible says Jesus took Satan very seriously. During Jesus ministry here on earth Jesus's emphasis was to Proclaim and Reclaim; including reclaiming us from the bondage of death. Even today Christ followers have a message of freedom from death to share; here's Rick with that amazing story! To support this ministry financially, visit: https://www.oneplace.com/donate/326/29

This week's episode focuses on Christopher “Chris” Schuler—his journey as a son, father, and most notably, a devoted caregiver. Chris, adopted from Colombia and raised in a loving, close-knit family in New York, reflects deeply on identity, belonging, and the power of chosen family. His parents' move to Rhode Island marked a period of even stronger family bonds, which would later prove invaluable when his father was diagnosed with glioblastoma, an aggressive form of brain cancer. The diagnosis and subsequent caregiving experience were transformative for Chris: he describes the initial shock, the emotional toll of shifting immediately into crisis mode, and the unwavering determination to care for his father, drawing strength from childhood lessons of love, attachment, and resilience.Throughout his father's illness, Chris balanced being a parent himself, maintaining his job, and providing near-round-the-clock care. He candidly shares the physical and mental challenges of caregiving, including the toll on his own health and the burnout that caregivers often experience. Yet, amidst the difficulty, he found meaning by staying present, bringing humor to dark moments, and cherishing precious time with loved ones. The experience has forever changed Chris—today, he proudly claims his identity as “Dad,” guided by his father's legacy of love and laughter, and is committed to using his voice to support and advocate for other caregivers navigating similar journeys.About Chris:Chris is a staunch brain cancer awareness advocate. He was the primary caregiver to his late Dad, Donald Schuler, who was diagnosed with GBM in July 2021. He works closely with biotech's and patient advocacy organizations across the globe, amplifying their critical work and building key relationships to further improve outcomes for patients. He spent eighteen years as a successful philanthropic facilitator, having raised millions for a variety of causes. He's currently a Venture Partner with Varia Ventures, working to raise awareness for emerging venture funds dedicated to uncovering and funding innovative discoveries to improve brain health. Chris continues as his Dad's caregiver — caregiver to his life, legacy and memory.    Thank you to sponsor: CareScoutSupport the showConfessions of a Reluctant Caregiver Sisterhood of Care, LLC Website: www.confessionsofareluctantcaregiver.com Like us on Facebook! Tweet with us on Twitter! Follow us on Instagram! Watch us on Youtube! Pin us on Pinterest! Link us on LinkedIn!Tune in on Whole Care Network

In this episode of Curing with Sound, we explore a groundbreaking approach to one of medicine's toughest cancers, glioblastoma (GBM), with Michael Canney, PhD, Chief Scientific Officer at Carthera. GBM is the most aggressive form of brain cancer, notoriously hard to treat because the blood-brain barrier (BBB) blocks many life-saving drugs from reaching tumor cells. With survival rates of just one to two years, new approaches are urgently needed. Dr. Canney shares how Carthera's SonoCloud-9, an implantable, therapeutic ultrasound device, temporarily opens the BBB and enhances the delivery of circulating drugs to the brain. He also discusses the SONOBIRD clinical trial, comparing the use of Carthera's SonoCloud-9 device combined with chemotherapy to standard-of-care therapies in patients with recurrent GBM. Discussion highlights: Phase III SONOBIRD Trial: The largest clinical trial in Carthera's history, enrolling 560 patients across the United States and Europe. The trial's goal is to demonstrate a survival advantage for patients with recurrent GBM when BBB opening is combined with the delivery of carboplatin chemotherapy, as compared with standard of care. Revolutionizing Drug Delivery: How SonoCloud-9 opens the BBB to increase carboplatin concentrations five- to seven-fold, potentially unlocking the full potential of existing cancer drugs that previously couldn't reach brain tumors. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.  Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.  FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

Welcome to the TCH broadcast! TCH is a ministry of Gospel Broadcasting Mission.GBM's mission is to broadcast the message of Jesus, in their own language, to unreached people groups and tribes world-wide.So, our first thought of Jesus is not usually that of a freedom fighter. But truth is, He was, in fact, he liberated people from the powers of darkness so they could become who they were created to be. What was true then, is still relevant today! And this month, Rick Atchley, Senior Minister with The Hills Church in Fort Worth Texas is exploring what that looks like in this month's series; “No Longer Slaves”.This time of year, there is a lot of lightheartedness surrounding the Devil and his darkness. However, the Bible says Jesus took Satan very seriously. During Jesus ministry here on earth Jesus's emphasis was to Proclaim and Reclaim; including reclaiming the sick from various sicknesses and disease. In today's message Rick emphasizes how Jesus's compassion toward our suffering has not changed and how Christ followers can be effective through prayer in combating the tyranny of disease. Here's Rick… To support this ministry financially, visit: https://www.oneplace.com/donate/326/29

Send us a textThe Accelerators co-host Dr. Matt Spraker is joined by two experts in brachytherapy for brain tumors, Radiation Onocologist and CMO of GT Medical Technologies Dr. Michael Garcia, MD, MS and Neurosurgeon Dr. Simon Hanft, MD, FAANS.We first review the origin story of GammaTile, an evolution of the practice of brachytherapy for brain tumors. Simon then shares how he has deployed GammaTile in his practice. We dive in to patient selection, how the design facilitates a shallow technical learning curve, and the process of prescribing and placing the implant.Discussion then shifts to research. We review some of the published studies (see links below) that support use of GammaTile for both brain metastases and recurrent primary brain tumors, such as GBM and meningioma. We also discuss some recently completed and soon-to-open trials, including Mike's creative idea - time intensification! -  to move the needle on outcomes for glioblastoma. Here are some of the studies we discussed and other useful links:The ROADS Study The GESTALT StudyEkhator et al., Review of GammaTile Studies Prasad et al., Radiation Protection Considerations for GammaTileGriffin et al., Fast Neutron Therapy for GBMBeckham et al., GammaTile for Salvage of Recurrent Brain Mets and a nice industry summary of findings in context (BioSpace)Dr. Simon Hanft, Building a Successful GammaTile Program (YouTube)A nice Insta patient video by a Dr. Bohnen, a neurosurgeon at Matt's centerEditor's Note: TAP were compensated for this episode and GT Medical Technologies participated in planning the content. The discussions in this episode are the opinions of the participants and are not clinical advice.Please see our website for complete information on our past and current sponsors.The Accelerators Podcast is a Photon Media production. 

Gabe is back with a brand new Gabe's Big Move to talk about the evolution of #Survivor juries and what it means to be a juror!Subscribe to the Reality Aftershow and follow Gabe on socials @gabeortisCheck out the ALL NEW RealityAfterShow.com official website!Join Jonny LIVE SurvivorTix.comBecome a supporter of this podcast: https://www.spreaker.com/podcast/reality-after-show--5448874/support.

Check out this week's QuadCast as we highlight how intranasal mupirocin decreases radiation dermatitis associate with nasopharynx radiation, the lack of benefit of immunotherapy in MGMT-unmethylated GBM, the role of neoadjuvant chemoradiation in unresectable pancreatic cancer, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom

Check out this week's QuadCast as we highlight a PSMA Theranostic contender, new guidelines (and name) for GBM, current management limitations in NSCLC, and more. Check out the website and subscribe to the newsletter! www.quadshotnews.com Founders & Lead Authors: Laura Dover & Caleb Dulaney Podcast Host: Sam Marcrom

Granulomatosis with Polyangiitis (GPA) – Recognition and Management in the ED Hosts: Phoebe Draper, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/GPA.mp3 Download Leave a Comment Tags: Rheumatology Show Notes Background A vasculitis affecting small blood vessels causing inflammation and necrosis Affects upper respiratory tract (sinusitis, otitis media, saddle nose deformity), lungs (nodules, alveolar hemorrhage), and kidneys (rapidly progressive glomerulonephritis) Can lead to multi-organ failure, pulmonary hemorrhage, renal failure Red Flag Symptoms: Chronic sinus symptoms Hemoptysis (especially bright red blood) New pulmonary complaints Renal dysfunction Constitutional symptoms (fatigue, weight loss, fever) Workup in the ED: CBC, CMP for anemia and AKI Urinalysis with microscopy (hematuria, RBC casts) Chest imaging (CXR or CT for nodules, cavitary lesions) ANCA testing (not immediately available but important diagnostically) Management: Stable patients: Outpatient workup, urgent rheumatology consult, prednisone 1 mg/kg/day Unstable patients: High-dose IV steroids (methylprednisolone 1 g daily x3 days), consider plasma exchange, cyclophosphamide or rituximab initiation, ICU admission Conditions that Mimic GPA: Goodpasture syndrome (anti-GBM antibodies) TB, fungal infections Lung malignancy Other vasculitides (EGPA, MPA, lupus)