Podcasts about MTX

Hosts: Shane, Tanis, Thaxy, and Tim Drop table changes are coming soon, will they make the economy better? With the balance of skilling and PvM at play we discuss why MTX is not the problem - this time. Also, the player support roadmap and more from the RSBANDB group ironman group. For detailed show notes visit update.rsbandb.com. You can also check out the forums for detailed discussion on each episode.Duration: 2:02:27

Kress is fresh back from Turkiye, sharing on-the-ground insights before diving headfirst into the week's big beats. We break down Epic Games Store's revenue, debate the Minecraft movie's potential for franchise dominance, and unpack the latest M&A and investment trends shaping gaming's future. Inflation's creeping impact on game pricing gets a hard look, while the crew wrestles with the evolving MTX and revenue models. Things heat up with Marvel Rivals throwing punches at Overwatch, a sharp take on Western vs. Eastern LiveOps strategies, and a no-holds-barred discussion about Bungie's Marathon pivot into extraction shooters. To wrap, a quick (and slightly roasted) look at Kingdom's celebrity-packed ad campaign.00:00 Introduction and Host Introductions03:09 Chris' Insights from Turkey07:02 Epic Games Store Revenue Discussion13:30 Minecraft Movie and Franchise Management21:07 M&A and Investment Trends in Gaming29:47 Game Pricing and Inflation30:31 MTX and Revenue Models32:59 Marvel Rivals vs. Overwatch37:33 Western vs. Eastern LiveOps44:24 Marathon: The Extraction Shooter58:13 Kingdom's Celebrity Ad Campaign

Wow! GGG is coming out shooting! The number of patches and posts that came out this week shows that Path of Exile is full speed ahead. So many big changes came with patch 0.2.0E, along with many other patches, that Dawn of the Hunt is already a very different beast than it was last week. We hope the changes suit you and as always we thank you for your time each and every week. You all rock.(00:00:00) Intro, Life Updates & Home Renovations(00:07:40) Dog Talk & Family Banter(00:11:10) Path of Exile Begins(00:18:05) Patch 0.2 Reflections & Early Access Changes(00:27:33) Re-rolling Characters and Testing Changes(00:37:50) Active Development & GGG Transparency(00:47:05) Patch Notes Deep Dive(00:57:42) Announcements, MTX, and Community Feedback(01:08:33) Favorite Armor Sets & Visual Design(01:18:10) Endgame Systems & Wrap-UpForever Exiled Info:www.foreverexiled.comPatreonTwitter @ForeverExiled82Path of Exile WebsiteWrecker of Days Builds ListDiscord...FE Merch StoreFE Nexus Store

Episode 218: Joel Reader of The Fatal Flaw, MTX, The Plus Ones, Pansy Division, The Bomb Bassets, and Avengers talks to us about how California is vast, Hardwired to have a melody and pop sensibility, Mother's chamber trio dreams, Joining MTX as a big fan was like a mentor project, Cello to drums to bass, Dissecting regret, Moving from California to Boston and the origin story of The Fatal Flaw, Power pop talk, plus much much emotionally motivated intellectually charged more more more!The Fatal Flaw WebsiteThe Fatal Flaw Bandcamp

Au programme :Microtransations: l'UE serre la vis.Steam arriverait sur Xbox? Quelle forme ça pourrait prendre?Pour le fun: dernières prévisions Switch 2 avant l'annonce.Nos jeux du momentThe First Berserker : KhazanKarma : The Dark WorldBLEACH Rebirth of SoulsTwo Point MuseumAC ShadowsLe reste de l'actualité---Infos :Animé par Patrick Beja (Bluesky, Instagram, Twitter, TikTok)Co-animé par Cassim Montilla (Bluesky).Co-animé par Jules Seigneur « Cael » (Bluesky)Produit par Patrick Beja (LinkedIn) et Fanny Cohen Moreau (LinkedIn).Musique libre de droit par Musicincloud.Le Rendez-vous Jeux épisode 392 – Khazan, Karma, Bleach, Museum, Shadows: le visuel qui tappe – UE vs MTX, Steam sur Xbox, prédictions Switch 2---Liens :

Hosts: Shane, Earth, and Lemon Jagex’s 2023 financial report is published and we delve into the numbers. We discuss why MTX was down and subscriptions were up and what this means for the future of RuneScape. Also this week, Shifting Sands brings a new cosmetic for 110 Runecrafting. For detailed show notes visit update.rsbandb.com. You can also check out the forums for detailed discussion on each episode.Duration: 1:52:01

Projekt Callisto známého kryptotěžaře Vladimíra Vencálka se měl stát českým digitálním impériem. Stejnojmenná kryptoměna a její blockchain měly být provázané se sítí nových datových center i s obchodem s digitálním uměním. Hlavním investorem se stala firma MTX miliardáře Petra Otavy. Po sérii problémů kryptoměna ztratila důvěru a přišla o svou hodnotu, některé firmy skončily v insolvenci, majetek jiných se prodával. Spory se vedou o to, za šlo o investiční podvod Vladimíra Vencálka nebo o tunelování firem ze strany MTX Group, která z celého projektu odešla se dvěma rozsáhlými datovými centry. Adély Gajdicové se na souvislosti sporů ptal Petr Gojda. Chcete dostávat výběr toho nejčtenějšího z našeho webu emailem? Odebírejte ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠newsletter investigace.cz. (https://investigace.ecomailapp.cz/public/form/7-c01458c4e85a58f0047857fac06ae283)⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Sledujte nás také na našem ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebooku⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠X(Twitteru)⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠,⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagramu.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 

Ep 248 Chris Camozzi BEFORE the UFC Ep Chris Camozzi is a 20 fight UFC veteran and the Bare Knuckle Fighting Championship 205lbs World Champion. Camozzis journey to the UFC is starts at the grassroots of the Denver Colorado scene; this is a fun listen Chris Camozzi BEFORE the UFC Ep 2480:00 plugs/ promotions 0:42 Lytes out intro 1:01 guest introduction 1:15 interview start 1:49 Chris Camozzi vs Sawyer Depee 6:47 training with Chael Sonnen9:25 meeting Chael Sonnen 13:14 connecting with Chris Weidman 17:12 training fighters in New York 19:47 Chris Weidman fighting with broken foot 21:43 UFC fighters coming from Denver Colorado 24:03 Brad Gumm31:30 Chris Camozzi vs Damon Daniels31:52 posting fighting videos on Live leak36:00 thoughts going into Damon Daniels fight 41:25 current life 43:03 incident at work event 47:09 Ian Heinisch story 53:57 deciding to pursue fight career  55:32 Chris Camozzi vs Spencer Hooker 57:06 Gustavo Machado 57:46 Chris Camozzi vs Donnie Liles 59:21 promoter Mark Pavelich 1:01:41 Chris Camozzi vs Jesse Forbes 1:03:30 Chris Camozzi vs Nick Rossborough1:04:33 MTX audio sponsor 1:06:48 Chris Camozzi vs Victor Moreno 1:08:44 manager Jason Genet 1:10:29 training with Jamie Varner 1:12:00 Chris Camozzi vs Jesse Taylor 1:15:32 victory Jay1:17:05 not getting picked for TUF 7 1:19:08 Chris Camozzi vs Chad Reinder 1:19:22 getting the call for TUF 11 1:22:12 jaw break during filming of TUF 11 1:29:30 interview wrap up/ outro Subscribe to the Lytes Out Podcast:https://www.youtube.com/@LytesOutClipsSocials: Facebook -https://www.facebook.com/groups/1027449255187255/?mibextid=oMANbwInstagram - https://www.instagram.com/lytesoutpodcast/iTunes - https://podcasts.apple.com/us/podcast/lytes-out-podcast/id1568575809 Spotify - https://open.spotify.com/show/3q8KsfqrSQSjkdPLkdtNWb Mike - The MMA Detective - @mikedavis632 Cash App - $mikedavis1231Venmo - Mike-Davis-63ZELLE: Cutthroatmma@gmail.com / ph#: 773-491-5052 Follow the #LOP team on Instagram: Chris - Founder/Owner - @chrislightsoutlytle Mike - MMA Detective - @mikedavis632 Joey - Assistant - @aj_ventitreTyson - Producer - @ty.green.weldingAndrew - Timestamps - @ambidexstressAndy - Social Media Manager - @martial_mindset_Outro song: Power - https://tunetank.com/t/2gji/1458-power#MMA #UFC #NHB #LytesOutPodcast #LytesOut #MixedMartialArts #ChrisLytle #MMADetective #MikeDavis #MMAHistory #OldSchoolMMA #FiftyFightClub #MMAPodcast #FightPodcastSupport the show

Austin's favorite game, everyone else's most "alright" Halo title. Roam the streets of New Mombasa and join the hosts with a special Patreon guest to talk about Halo 3: ODST and the shift in the gaming space from content to MTX. This episode includes: Recapping Halo 3: ODST Talking Halo 3: ODST's marketing and release Comparing ODST's campaign to Infinite's campaign Talking with one of our top Patrons! The Library - Halo Lorecast is a JumperScape Media production created by Austin Murphy. "Keep What You Steal" composed by Jafet Meza. Learn more about your ad choices. Visit megaphone.fm/adchoices

Canada walks back Flipper Zero ban; Capcom destroys Dragon's Dogma 2 with MTX

Jez and Rand get into another week of Xbox Two podcasting. This week, we talk the Xbox handheld "rumors," the PS5 Pro vs. the Xbox Series X, Dragon's Dogma 2, Banishers: Ghosts of New Eden, and much more. PATREON: Support us and get extra shows and guaranteed Q&As on Patreon.com/XB2! DISCORD: Join us on our Discord.gg/XB2 server! MANSCAPED: Get 20% OFF at MANSCAPED.COM with code XB2. #ad TIMESTAMPS: 00:00:00: Intro. Thoughts on Dragon's Dogma 2 and MTX drama. 00:45:00: Xbox handheld rumors, Enotoria skipping Xbox. 01:30:00: PS5 Pro and should Xbox respond? Persona 6 rumors. 02:10:00: Bungie "underperforming," new Amy Hennig Marvel game. 02:45:00: Patreon Q&A. Learn more about your ad choices. Visit podcastchoices.com/adchoices

TIME STAMP INFO: 00:00:00 Intros 00:05:00 Dragons Dogma 2 Impressions & MTX's Being Added After Review! The Gaming Community Is NOT Happy About THIS! 00:50:00 Another Game Skipping Xbox Series X/S After Being Announced As An ID@Xbox Title, WOW! 01:20:00 Time To Get Excited About Xbox Again, NEW Hardware On The Horizon & It Could Be A "Native, Xbox Handheld", THIS Comes From Prominent Journalist, Jez Corden Of Windows Central! 02:05:00 Panel Outros and Special Message to the community! --- Support this podcast: https://podcasters.spotify.com/pod/show/craig-ravitch/support

Thanks Listener, Thankful to be an American, Thankful to meet and be friends with DJ Gower this is the gratitude edition. Matador returns from another trip to the Dominican and Gower talks home repair. Matador tells many Dominican tales and we play mostly hip hop and punk. Thanks for listening in the last 14 yrs totally thankful. Thank you, Matador Artist include: MTX, A Wilhelm Scream, Transplants and Many more.

In This Episode:EICMA 2023 Highlights: We kick things off with a roundup of the most exciting reveals from EICMA 2023, including the latest models from major manufacturers like CFMoto, Honda, Suzuki, Kawasaki, KTM, and Moto Guzzi.CFMoto's Latest Offerings: We delve into CFMoto's new MTX concept and the impressive MT450, discussing the potential impact on the adventure and naked bike segments.Honda's New NX 500: A closer look at Honda's NX 500, exploring its features and where it fits within Honda's lineup alongside the Transalp.Suzuki GSX-S1000GX: We analyze Suzuki's new sport-touring model, the GSX-S1000GX, its features, pricing, and how it compares to its competitors.Kawasaki Ninja 500 & Z500: Introducing Kawasaki's replacement for the Ninja 400 - the Ninja 500 & Z500, and discussing the implications of the new 451cc engine.KTM's Bold 990 Duke: A detailed discussion on KTM's 990 Duke, its unique design choices, and how it continues the Duke legacy.Moto Guzzi's Stelvio: We wrap up with a look at Moto Guzzi's Stelvio, comparing its design and features to other models in the adventure bike market.Q&A Session: We answer questions from the live audience, covering a wide range of topics from personal preferences to insights into the future of the motorcycle industry.Special Mentions:A shoutout to our spectral producer Ghost, who took on the role of camera car driver for our latest WBRGarage project.Birthday wishes to Specter, Ghost's son, a valued member of the Live OnTwowheels community.Support the Show: Find out how you can support the show and get involved with our community on WBRGarage.com, YouTube memberships, and joining our Discord.Next Episode: Tune in next week for more motorcycle news, reviews, and lively discussions. Don't forget to follow us on social media to stay updated on all things Live OnTwowheels!Join this channel to get access to perks:https://www.youtube.com/channel/UCRzHhmsrf_bVUBzg4KJUpvg/joinWant to SUPPORT the show? Sign up for our Bike Build Giveaways here:http://www.wbrgarage.comWelcome to LIVE Ontwowheels, the weekly motorcycle live show that covers all things motorcycle-related here on the Internet! This weeks episode is sponsored by Revzilla's RPM program: http://bit.ly/chaseRPMIt's amazon prime for motorcycle gear! Check it out at the link above!Audio Versions of the show HERE!Apple Podcasts: https://apple.co/2OW73gOSpotify: https://spoti.fi/2OFWpdOJoin our Live Ontwowheels DISCORD: https://discord.gg/8erHCTJMzk

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. How good (or not) are rheumatologists and what to do about MTX nodulosis?

Join Professor Iain McInnes in this month's CSF Podcast, where he discusses the latest information and data in rheumatology. In this episode, he discusses two papers that compare the efficacy and safety of JAK inhibitors as RA therapies. In our first paper, Shinya Hayashi and his colleagues carried out a retrospective study to compare the efficacy of JAK inhibitors in treating RA. For our second paper, Christina Charles-Schoeman and her colleagues compared the incidence of MACE and VTE in RA and PsA patients treated with upadacitinib, adalimumab and MTX.

Rocksteady's long-in-development multiplayer-centric Suicide Squad project has finally reemerged in anticipation of its February 2024 release on PlayStation 5, and the reception has been mixed at best. Kill the Justice League is entering a tough market wielding an oft-failed commercial strategy, but it's also true that DC products have the potential to be huge, and WB yearns for this style of game to truly hit. There's another possibility too, though: That everyone involved has made a very bad mistake and wasted nearly a decade on a boondoggle. Let's talk it through. Then: PlayStation Portal finally arrives, our beloved PlayStation 4 turns 10, Spider-Man 2 and PlayStation 5 dominate the sales charts, and more. Plus: Is DLC, expansion, and MTX pricing officially out-of-control? Will PlayStation premiere a game at the upcoming Game Awards? Could skill-based matchmaking be backfiring on audiences? Will one listener accept that he's attending a furry convention because he's in love with his best friend? Head to https://www.tryfum.com/SACRED and use code SACRED to save an additional 10% off your order today. Get 25% off your first order, plus free shipping at https://www.meundies.com/sacred Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode of Talking HealthTech, host Peter Birch is joined by Denisha Allicock, Public Health Strategist at MTX, and Bryan Tan, Chief Health Officer for Salesforce APAC. They discuss innovative solutions being developed in healthcare technology, particularly in the areas of mental health and integrated behavioural health. They delve into the importance of collaborative partnerships for innovation and the role of technology in connecting healthcare professionals and patients. Key Takeaways:

Omega-3s help isotretinoin - Covid and autoimmune disease - Transient abdominal telangiectasia of the newborn - Systemic tacrolimus in derm - MTX + prednisone for alopecia totalis/universalis - Tofacitinib for BP - Check out our video content on YouTube: https://www.youtube.com/@dermaspherepodcast and VuMedi!: https://www.vumedi.com/channel/dermasphere/ The University of Utah's Dermatology ECHO: ⁠⁠https://physicians.utah.edu/echo/dermatology-primarycare - ⁠⁠Connect with us! - Web: ⁠https://dermaspherepodcast.com/⁠ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! ⁠https://healthcare.utah.edu/dermatology/skincast/⁠ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - ⁠Kikoxp.com ⁠(a social platform for doctors to share knowledge) - ⁠https://www.levelex.com/games/top-derm⁠ (A free dermatology game to learn more dermatology!)

This Tuesday Night Rheumatology panel discussion on "Methotrexate Decisions" featured Drs. Michael Weinblatt, Grace Wright, Richard Conway and Joel Kremer. The​ Panel discussed folate & MTX dosing, side effect management, MTX & lung disease and optimal monitoring, with many audience questions.​Recorded on 9/19/2023

  - QD221: RA & Vaccination  (Dr. J. Cush) https://youtu.be/6qsz0TPVKLU   - QD222: Goal of the First Visit (Dr. J Cush)  https://youtu.be/EwsO9LCywzI   - QD223: MTX Pearls  (Dr. J Cush) https://youtu.be/fktKlc0Pk-o   - QD224: RA on MTX with Progressive Dyspnea (Dr. R. Conway)  https://youtu.be/g1Q_uG9zZ0g

Here are the stats posts: https://www.reddit.com/r/wow/comments/15fjudo/spec_balance_last_33_weeks_in_top_2000_m_keys/ and the Prot Paladin one: https://github.com/Strong-Deutan/WoW_Prot_Paladin_Analysis/blob/main/wow_paladin_analysis.ipynb Frost Mage Guide by Manather: https://www.youtube.com/watch?v=wXyG-YGswGM& Fire Mage Guide by Forgyy: https://www.youtube.com/watch?v=12iy8ICXuio Arcane Mage Guide by Phosphoros: https://www.youtube.com/watch?v=v8rFOzIEZpc NA's Last Hope Freehold Strat: https://www.twitch.tv/videos/1885719682?t=02h59m13s 0:00 Intro, News, MTX 23:00 Tip of the Week 29:00 Brackenhide Hollow 56:00 Patreon Thanks 1:00:00 Q&A Check out our Patreon at https://www.patreon.com/titanforge Come join our Discord: https://discord.gg/6BcJ3Tu Music: Take a Chance by Kevin MacLeod Link: https://incompetech.filmmusic.io/song/4457-take-a-chance License: http://creativecommons.org/licenses/by/4.0/

Hosts: Shane, Tanis, and Stormy Necromancy arrives on August 7th, the Demonic Skull continues to cause problems, and the Max and Comp capes get new Pride presets. Also, Stormy joins us to discuss the issues of the Soul Dye and how it relates to cluers, the economy, and MTX. For detailed show notes visit update.rsbandb.com. You can also check out the forums for detailed discussion on each episode.Duration: 1:35:38

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com, including new drug approval, a new SpA variant and new rules for methotrexate (MTX) monitoring and depression screening.

In a week full of VR competition ramping up and anticipation building up for Summer Game Fest, Xbox's Showcase, and the rest of the gaming industry to breath new announcements into life, we look at PSVR2's new games that came as part of it's competition announcing their next, or in Apple's case, first step into the market, Square Enix's strange marketing tactic in the build-up to more information on Final Fantasy VII: Rebirth, a talk about micro-transactions and their place in modern gaming amidst concerns that Diablo 4's MTX are a beacon of something worse, and get the Community's thoughts on PlayStation and their evolving business plan's impact on their first-party relationships. All this and more on this week's Triangle Squared: A PlayStation Podcast! Join us! Enjoy timestamps for topics below: ------------------------------------- What We've Been Playing - 0:00 The "Time & Place" of Trophies - 7:49 Diablo 4 Impressions - 18:13 Community's Take: Naughty Dog or Bungie? - 29:01 Gamers' Fear of Microtransactions - 39:45 News Start: Apple & Meta VR - 53:58 Payday 3 Leaked Release Date - 1:01:30 FF7: Rebirth Teases - 1:02:02 Netflix Continues to Build AAA Studio - 1:09:38 Question: Favorite Console Boot Sounds - 1:15:10 Question: Gut Feeling on PlayStation's Future? - 1:26:40 Velvet's Corner: Full Body Console Replacement - 1:50:25 ------------------------------------- New episodes posts every Monday at 12PM CST/10AM PST!This show is possible thanks to the support of our Patrons. Consider becoming one today at www.patreon.com/nartechDiscord Server: discord.gg/cEvKzqmTwitch: www.twitch.tv/nartechgamingEmail/Tweet us your thoughts & suggestions:Twitter: twitter.com/TriangleSqrdEmail: trianglesquaredpodcast@gmail.comPSN ID's: Add us! Brett - Chaimera086, Sol - MeteoricDemise, Chris - Figz21k#PlayStation #PlayStationPodcast #TriangleSquared

Vorweg: Schwachstelle in UEFI-BIOS von Gigabyte Mainboards, Updates werden verteilthttps://www.computerbase.de/2023-06/gigabyte-verteilt-updates-schwachstelle-macht-271-mainboard-modelle-angreifbar/ Microsoft stellt Windows 365 mit direktem Start in der Cloud vor, Nvidia präsentiert auf der Computex in Taipei eine Sammlung von KI-Applikationen für Spieleentwickler vor (mit hölzern agierendem NPC, aber das liegt vielleicht an unserer Wahrnehmung). Ja, Gollum von Daedalic… uff… und Redfall… aiaiai… da […] The post Folge 155: Meta Quest 3, Diablo 4 MTX, Redfall-Fail, Nvidia AI-NPC-Tools, Gigabyte Mainboards angreifbar appeared first on Technikquatsch.

Remember when pop-up ads looked like they were part of Windows XP? Dark patterns are all around us, even when we don't realize it, and this week we cover a wide range of these insidious methods of manipulating our online behavior, touching on everything from tricks to make you play games longer than you want to subtly enticing you to rope in your friends, succumb to sunk cost fallacy, and more. Editor's note: Brad played Clash Royale for three hours after recording this episode.Support the Pod! Contribute to the Tech Pod Patreon and get access to our booming Discord, your name in the credits, and other great benefits! You can support the show at: https://patreon.com/techpod

หากย้อนไปมองเพียง 20 ปีก่อนหน้านี้ เราจะเห็นว่า​ “โลกการตลาด” ในอดีตนั้น แตกต่างกับปัจจุบันอย่างมาก . เราเคยอยู่ในยุคที่แทบทุกอย่างโฆษณาผ่านทีวี แต่ตอนนี้กลับเป็นโซเชียลมีเดียที่มีบทบาท และในอนาคตก็อาจเปลี่ยนไปเพราะเทคโนโลยี อย่าง AI และ Marketing Technology ต่างๆ . ท่ามกลางความเปลี่ยนแปลงอันรวดเร็วนี้ นักการตลาดที่จะประสบความสำเร็จในอนาคต จะต้องพัฒนาทักษะสำคัญด้านใดบ้าง? . เรียนรู้ความเปลี่ยนแปลงในโลกการตลาด ไปกับคุณบี สโรจ เลาหศิริ Head of Marketing Transformation and Marketing Strategy ที่ Bluebik Group และยังเป็นผู้ร่วมก่อตั้ง และอดีต Chief Marketing Officer แห่ง Rabbit's Tale  และคุณจั๊ก กรกนก เชาว์ปรีชา ที่ปรึกษาคณะกรรมการบริหาร บริษัท ฤทธา โฮลดิ้ง จำกัด และผู้อำนวยการหลักสูตรสถาบันพัฒนาความคิดสร้างสรรค์เชิงธุรกิจ . พร้อมทำความรู้จัก  “MTX Marketing Transformation Xponential” โปรแกรมที่ผู้บริหารและผู้นำด้านการตลาดห้ามพลาด . เชิญรับฟังพร้อมๆ กันได้ใน EP. นี้ . สมัครหรืออ่านรายละเอียดเพิ่มเติม เกี่ยวกับโครงการ MTX ได้ที่ mtx.riseaccel.com/ . Mission To The Moon X MTX . #missiontothemoon #missiontothemoonpodcast

หากย้อนไปมองเพียง 20 ปีก่อนหน้านี้ เราจะเห็นว่า​ “โลกการตลาด” ในอดีตนั้น แตกต่างกับปัจจุบันอย่างมาก . เราเคยอยู่ในยุคที่แทบทุกอย่างโฆษณาผ่านทีวี แต่ตอนนี้กลับเป็นโซเชียลมีเดียที่มีบทบาท และในอนาคตก็อาจเปลี่ยนไปเพราะเทคโนโลยี อย่าง AI และ Marketing Technology ต่างๆ . ท่ามกลางความเปลี่ยนแปลงอันรวดเร็วนี้ นักการตลาดที่จะประสบความสำเร็จในอนาคต จะต้องพัฒนาทักษะสำคัญด้านใดบ้าง? . เรียนรู้ความเปลี่ยนแปลงในโลกการตลาด ไปกับคุณบี สโรจ เลาหศิริ Head of Marketing Transformation and Marketing Strategy ที่ Bluebik Group และยังเป็นผู้ร่วมก่อตั้ง และอดีต Chief Marketing Officer แห่ง Rabbit's Tale  และคุณจั๊ก กรกนก เชาว์ปรีชา ที่ปรึกษาคณะกรรมการบริหาร บริษัท ฤทธา โฮลดิ้ง จำกัด และผู้อำนวยการหลักสูตรสถาบันพัฒนาความคิดสร้างสรรค์เชิงธุรกิจ . พร้อมทำความรู้จัก  “MTX Marketing Transformation Xponential” โปรแกรมที่ผู้บริหารและผู้นำด้านการตลาดห้ามพลาด . เชิญรับฟังพร้อมๆ กันได้ใน EP. นี้ . สมัครหรืออ่านรายละเอียดเพิ่มเติม เกี่ยวกับโครงการ MTX ได้ที่ mtx.riseaccel.com/ . Mission To The Moon X MTX . #missiontothemoon #missiontothemoonpodcast

Join Prof Iain McInnes as he reviews two interesting papers. In the first paper the authors cover aspects from mean disease activity scores after tapering to radiographic outcomes and safety, to help ascertain whether it is possible to withdraw MTX while maintaining disease control. The second paper then goes on to also analyse MTX withdrawal data, but this time to evaluate the performance of disease activity metrics. Everything discussed is available in a more detailed slide format in the publications section at cytokinesignalling.com

It's Christmas time! And what a crazy time to release the coolest support packs we've ever seen! It's an MTX fiasco this week! Return all of the gifts you've bought for others! It's time to stock up in GGG Land! Path of Exile also came out with their huge 3.20.1 patch this week that added a whole bunch of different fixes, modifications, and additions to the game. Forbidden Sanctum is looking a little more spicey for close-quarter-combat players. Oh! Don't forget to update your filters! Episode 168 was another "double episode" as we talk non-stop about our re-rolls, atlas passive trees, build comparisons...we're loving Path of Exile and hope you are too. Thanks for listening each week! Merry Christmas to you and yours! (Stop by our Discord if you want some encouragement and company. It's loaded with people that really do care for you!)Forever Exiled Info:www.foreverexiled.comPatreonTwitter @ForeverExiled82Path of Exile WebsiteWrecker of Days Builds ListDiscord...FE Merch StoreFE Nexus Store

Mission Daily Report December 23, 2022 1. ราคาดัชนีตลาดหลักทรัพย์ / ราคาหุ้นต่างประเทศ / ราคาน้ำมันดิบ / ราคาทองคำ / ราคา Cryptocurrency 2. คาดราคาน้ำมันอาจพุ่งแตะ 121 ดอลลาร์ หากจีนเปิดประเทศเต็มรูปแบบ 3. คาดการท่องเที่ยวช่วงปีใหม่ทำเงินสะพัด 4. กำหนดเพดานก๊าซธรรมชาติของ EU แก้ปัญหาจริงไหม 5. โจ ไบเดน' เปิดทำเนียบขาวต้อนรับ'เซเลนสกี' สนับสนุนอาวุธสู้รัสเซีย 6. รู้ไหมเมนูเฉลิมฉลองคริสต์มาสในแต่ละทวีปมีอะไรบ้าง 7. Google ประชุมด่วน หลัง ChatGTP เริ่มทำงานได้เยอะขึ้น 8. เปิดตัวคอร์ส MTX หลักสูตรทรานส์ฟอร์มนักการตลาดแรกของไทย 9. 'คมนาคม' เปิดแผนลงทุนปี 2566 อัดงบกว่า 3.1 แสนล้านบาท 10. ญี่ปุ่นเผยค่าเฉลี่ยอุณหภูมิสูงขึ้นต่อเนื่องเริ่มอันตราย 11. WISESIGHT เผยสถิติศัพท์โซเชียลสุดฮิตประจำปี 2022 12. เรือหลวงสุโขทัยล่ม ความเสียหายจากความไม่พร้อม 13. แหกศาลหนี ทำไมถึงทำได้อย่างง่ายดาย

Join Prof Iain McInnes as he reviews two interesting papers. The first paper aimed to compare the risk of MACEs and VTEs for patients initiating a JAKinib (tofacitinib and baricitinib) and those initiating adalimumab (TNFi) among a large and comprehensive real-world population of patients with RA. Our second paper aimed to evaluate the efficacy and safety of FIL200 and FIL100 compared with placebo and ADA, all with background MTX, in patients with MTX-IR RA in subgroups of those with all four PPFs versus those with fewer than four PPFs. Everything discussed is available in a more detailed slide format in the publications section at cytokinesignalling.com.

This week we talk about the cool things going on at SEMA! We talk about the cool shows we will be going to this weekend! I will be at Santa Drag in Piney Flatts. And Dizzy will be in Knoxville at Strike up the band! Show. We touch base with our Relaxed Atmosphere brothers and sisters at SEMA ! Brett Hunsaker checks in.We hear from our boy Shane Andrews parked at the MTX booth! And a lot more goodies!! Remember to check out The Custom Scene Podcast on most media platforms and now YouTube. We would like to thank our sponsors Asphalt Army The grande finale show HammerD Weekend Wear EASTBOUND GETDOWN SHOW presented by Stingray Chevrolet Layin Frame Kandles The Sparks show 2023 Showdown in the Valley 2023

Mathieu Bassée est directeur artistique de studio Mtx. A travers son témoignage, vous allez assister à la rencontre entre un homme et un atelier. La façon dont un destin se tricote pour permettre à un étudiant d'école de commerce devenu designer de prendre la direction et de porter la vision d'un atelier de broderie. Pas n'importe quel atelier. Studio Mtx a inventé le terme de broderie architecturale et ouvert la voie pour les autres métiers de la haute couture qui voulaient explorer une nouvelle échelle et un nouveau marché. Mathieu Bassée c'est le goût, la passion et la détermination mis au service d'un savoir-faire et Mathieu Bassée c'est aussi une vision du design qui nous parle et que l'on veut faire mettre en lumière.

The attendees can expect two highly interesting interviews with two well-known experts in the field of rheumatoid arthritis, namely Prof. Gerd Burmester and Prof. Mikkel Østergaard. Prof. Burmester provides expert tips around MTX treatment of RA patients in the context of COVID-19 vaccinations and elaborates the effects of MTX hold on the vaccination response. Prof. Østergaard elucidates the role of Methotrexate as an anchor drug in the treatment of rheumatoid arthritis, including the possibility of using it in a combination therapy. Furthermore, the advantages of subcutaneous Methotrexate over oral Methotrexate are highlighted. This podcast has been funded by medac Gmbh, the market leader and innovator in scMTX therapy

C'mon Mickey, we're saving the valley! On this week's GoGCast, Leah reviews Disney Dreamlight Valley, a take on a farming and life simulator with a Disney twist. Plus, we round-up the announcements from the Disney & Marvel Games Showcase and Ubisoft Forward. What is Everyone Playing? (00:28:14) Disney Dreamlight Valley (00:30:45) This Week's News (00:45:00) Rumour: Overwatch 2's will lock new heroes behind MTX (00:47:25) Elden Ring's soundtrack is on Spotify, Apple Music, Youtube (00:55:07) Disney & Marvel Games showcase (00:58:02) Ubisoft Forward (01:04:12) Outro and Wrap-up (01:21:28) -- Thanks for listening! The GoGCast comes out weekly so make sure to subscribe and you won't miss an episode. For more about us, Girls on Games, check out girlsongames.ca. Find our Merch at http://www.designbyhumans.com/shop/GirlsOnGames/ Buy us a Ko-Fi at https://ko-fi.com/girlsongames

TIMESTAMPS Some useful timestamps:[Links not showing? Please visit: https://getlpodcast.com]00:00 - Intro - Welcome to Episode 93!02:15 - Understanding MTX & DLC04:30 - Historical first experiences09:00 - Late stage capitalism14:00 - Tangible Subscriptions16:30.- BMW's subscription faux pas21:00 - Some trends should not be followed26:00 - Past predicts future29:00 - Dangerous precedents34:30 - Outro - Thanks for listening!If you enjoyed, please give us a good rating.

Last week, the US Food and Drug Administration (FDA) approved the co-treatment of pegloticase (Krystexxa) injection plus methotrexate (MTX) for uncontrolled gout, a decision bolstered by data from phase 4 of the MIRROR study. In that study, 71% of patients who were treated with this combination therapy achieved a complete response over the course of 6 months. Comparatively, only 38.5% of patients who received pelgoticase plus placebo achieved a complete response. In a then-recent statement, John Botson, MD, RPh, Rhuematology Director at Orthopedic Physicians Alaska stated that the medical community had been “actively engaged” in findings therapeutic options for uncontrolled gout via pelgoticase therapy. As one of the primary investigators of the MIRROR study, Botson was keenly aware of the implications of this new FDA decision, noting that this new co-treatment option could allow clinicians to “change outcomes for many uncontrolled gout patients, most of whom have no other treatment option." For this episode of DocTalk, Botson sat down with Associate Editor Giuliana Grossi and spoke of how combination therapy for gout has led to less infusion reactions and increased efficacy, as well as how clinicians have safely incorporated low dose methotrexate, and what he feels will be the future of gout research. “In the previous studies, about a quarter of the patients would have infusion reactions and lead to some of the side effects that came from getting the medication, and in this case we had 30.6% of the patients on the placebo who didn't take the methotrexate, and only 4.2% of the ones that got the combination,” Botson said. “So basically, there was a 90% or so improvement in safety and a doubling of the efficacy by using the combination. Those were huge, huge takeaways.” 

Featuring: Ammosart, Ashgar, Belghast, Grace, Tamrielo, and Thalen   Tonight we have a show where we are mostly discovering games that have been out for a very long time.  We start off with Rimworld and Tam's adventures in this story generation engine.  From there we talk about Wolfstride and how it is a very 90s anime representation of a video game.  From there Tam talks a bit about the Star Citizen Guide program that links someone needing help with a live person to help them, and how recent changes have made that system work strangely.  Finally, we dive into Path of Exile and how the rabbit hole has widened and captured most of us.  We talk about confronting the passive tree and the weird edge case builds it can support along with some early multiplayer experiences.  We also talk a bit about how important it is for games to support a controller and a mouse and keyboard to meet the players where they are most comfortable.  Finally, we dive a bit into the microtransactions within Path of Exile and their general acceptance. Topics Discussed Rimworld Adventures Wolfstride Very 90s Anime Game Star Citizen's Guide System Echos of Everquest Guide System Path of Exile The rabbit hole widens Multiplayer experiences Controller Support in ARPGs Acceptance of MTX

In this episode of the Special Needs Supermom Podcast I talk about signs and symptoms of special needs children: real issue or talked into? *When you're autistic you're anti-social; when there's a smog weather alarm you have to stay inside when asthmatic; all kids taking MTX-injections get ‘allergic' to the color yellow, the smell of fresh cut grass is enough to trigger an asthmatic allergy attack. Or is it because society keeps telling us this?  *Wonderboy is the most social sensitive kid out there, hence why people always question him being autistic. Yet he nowadays calls himself socially awkward. Supergirl never thought much about the yellow color of her juvenile arthritis injectable medicine until she heard other kids talk about being ‘allergic' to the color yellow because of this med. She has a yellow wall in her bedroom… And for years I would start to breath difficulty the moment I smelled mowed grass. Until my breathing therapist asked if this was truly an allergic reaction or happened because I would tense up and breath shallow the moment I would smell it. *What raises the question: when it comes to signs and symptoms of our special needs children, but also our own, is it really true or talked into?  *Stay sane & stay happy.  Nadine  *Find and recharge your superpowers at: -        www.specialneedssupermompodcast.com -        IG: @specialneedssupermompodcast -        FB: www.facebook.com/specialneedssupermompodcast *Supermom tribe Looking for a private tribe just for fellow special needs moms to hang out, share stories, laugh, cry, get inspired, share tips and keep sane? Join the private Facebook group: https://www.facebook.com/groups/specialneedssupermoms  *Sponsors and partnership Email specialneedssupermompodcast@gmail.com for sponsor opportunities and partnership possibilities. *#asthma #autismsigns #autismspeaks #autismawareness #adhdsigns #adhdwomen #adhdmom #autismmom #juvenilearthritis #kidsgetarthritistoo #chronicillness #specialneedsmom #specialneedschildren

Prof Iain McInnes reviews three papers this month!. The first – from Taylor et al – looks at pain control in early RA treated with baricitinib, the second investigates the immunogenicity of pneumococcal vaccination in patients with RA receiving upadacitinib and MTX, and the third paper is a perspective on regulatory changes in the wake of the ORAL SURVEILLANCE results. Keep up to date with the latest in arthritis and cytokine signalling with Prof Iain McInnes. Everything discussed is available in a more detailed slide format in the publications section at cytokinesignalling.com.

This week I talk with the punk rock legend that is John Jughead Pierson! You know Jughead from Screeching Weasel, Even in Blackouts, The Mopes, The Mitochondriacs and his podcast Jughead's Basement. On this episode we talk-creativity that you can't turn off-how John losing his record collection was a catalyst for Jughead's Basement-revisiting early Screeching Weasel for inspiration for The Mitochondriacs-the similarities and differences between writing a play and writing a song-the far reaching (and long lasting) impact of Lookout Records-the importance of travel and seeing the world-using improv skills to podcast-picking up the songwriting duties in Even In Blackouts-how Johns mind forced him to write songs again after taking a break-breaking strings and breaking guitars with your strumming-finding inspiration for music and art in the world-why Al Sobrante has an executive producer credit on My Brain Hurts & much moreFollow John https://www.jugheadsbasementpodcast.comhttps://themitochondriacs.bandcamp.comhttps://eveninblackouts.bandcamp.comhttps://www.youtube.com/user/JohnJugheadhttps://www.instagram.com/johnjugheadpiersonhttps://www.instagram.com/jugheadsbasementhttps://www.facebook.com/MemoriesOfAJugheadCheck out the Power Chord Hour radio show every Friday night at 10 to midnight est on 107.9 WRFA in Jamestown, NY. Stream the station online at wrfalp.com/streaming/ or listen on the WRFA app.powerchordhour@gmail.comInstagram - www.instagram.com/powerchordhourTwitter - www.twitter.com/powerchordhourFacebook - www.facebook.com/powerchordhourYoutube - www.youtube.com/channel/UC6jTfzjB3-mzmWM-51c8LggSpotify Episode Playlists - https://open.spotify.com/user/kzavhk5ghelpnthfby9o41gnr?si=4WvOdgAmSsKoswf_HTh_Mg

New to RheumNow?  Rheumnow.com is a news source dedicated to the field of Rheumatology. It is written by experts in the field, and written for rheumatologists and individuals working in related fields.  In this episode, Dr Jack Cush reviews the news, journal articles and FDA warnings from the past week on RheumNow.com A population based Swedish study of birth records shows that antibiotic exposure in first three years of life to be associated with a future risk of JIA, although infections during fetal life or childhood did not increase risk of JIA. #RheumNow https://t.co/Md0zBm5Txl Alendronate may protect against type 2 Diabetes. Data from National Danish Patient Registry, presented at the EASD meeting compared 160k T2DM & 500k controls, T2DM following alendronate adjusted OR=0.64; 0.62-0.66; ⋗8yrs OR=0.47 https://t.co/RYEZodUZtv Analysis of 508 #RA pts (over 10 yrs) in the BeST study shows joint swelling at baseline resulted in half w/ re-swelling later and significantly increased risk of same joint swelling during follow-up (OR 2.37, 95% CI 2.30 to 2.43, p⋖0.001) https://t.co/a7zH4YRAkq Finnish Pop study 939 #RA pts shows highest healthcare costs linked to high Dz activity & comorbidity. Clusters: C1) young w/ low costs & activity, C2) chronic pain, disability, fatigue, C3) high cost/dz activity, less pain, C4)comorbidities w/ $$$  https://t.co/Azc35zyA9J A longitudinal study from Iceland shows an increasing number of native joint infections (NJI), with iatrogenic, postarthroscopic infections being of particular concern. Read more… https://t.co/j3gzZ9g0QV Case controlled study suggests that intraarticular steroid injections is associated with increased (HR 8.56; 3.29-22.3) risk of rapidly destructive hip disease (RDHD); at a rate of 5.4% (5.1 mos post injx) w/ JSN, osteolysis, fem head collapse https://t.co/grX5bO4495 Biosimilar update: 31 FDA approved biosimilars, but only 60% made it to market. 2015 to 2019, drug spending grew 6.1%, biologic spending grew 14.6%; biologics are 43% of US drug spending. Most biosimilars at ~30% discount.  https://t.co/4paYH8yVLQ Study Finds U.S. Generic and Biosimilar Savings Totaled a Record $338 Billion in 2020  https://t.co/hPR0nGd6jp Can I get the INFLUENZA and COVID Vaccines together? The CDC says: "YES...both vaccines can be given at the same visit, people should follow the recommended schedule for either vaccine.... ideally get a flu vaccine by the end of October."  https://t.co/T49zm6Cxyc MMWR shows the safety of a 3rd (booster) dose of the mRNA vaccine to be same as the 2nd dose AEs. V-safe data on 3rd dose (n=12,591) showed local or systemic effects (79% or 74%) to be same as 2nd dose (78% or 76%)  https://t.co/LcD0ARlWJ2 CDC Advises COVID-19 Vaccines for Pregnant Women https://rheumnow.com/news/cdc-advises-covid-19-vaccines-pregnant-women U.S. Preventive Services Task Force (USPSTF) reaffirmed its recommendations that pregnant women at a high risk of preeclampsia should take a daily aspirin regimen at the end of the first trimester  https://t.co/DiV7p6g8vL Is Acetaminophen Potentially Hazardous in Pregnancy?  https://rheumnow.com/news/acetaminophen-potentially-hazardous-pregnancy #RA patients had an an increased risk of mortality after CABG (HR 1.50; 1.28-1.77); and a higher risk of MI following CABG (HR 1.61; 1.28-2.04). A retrospective Finnish study comparing RA (n= 378) to nonRA patients (n = 7560)  https://t.co/cGGsrLs1V2 Early Diastolic Dysfunction in Premenopausal Women with RA  https://rheumnow.com/news/early-diastolic-dysfunction-premenopausal-wom… 108 pts with autoimmune cytopenias (TTP, ITP, AIHA, etc) were given COVID vaccination showing low rate of post-vax flares. Signif HEME decreases in 7.4% of AIHA & ITP; mild decrease in 10% AIHA and 20% ITP, w/ no Rx change https://t.co/OaHILar57z Global SECURE-IBD trial on IBD drugs and COVID shows that severe COVID-19 outcomes were not associated with the use of biologics and mesalamine/sulfasalazine, AZA, 6MP, MTX combo Rx or biologics (TNFi, IL-12/23, IL-23, integrin inhib)  https://t.co/MO4i5ngKkr Questions & Cases Approach to dental surgery while on bisphosphonate Recurrent shingles while on adalimumab Myositis after COVID-19 vaccine CONNECT WITH RheumNow  ✩ Website - https://rheumnow.com/ ✩ Subscribe @ RheumNow: https://rheumnow.com/user/register ✩ LinkedIn - https://www.linkedin.com/in/john-cush... ✩ RheumNow LinkedIn: https://www.linkedin.com/company/rheu... ✩ Twitter - https://twitter.com/RheumNow Listen | PODCAST Apple Podcasts: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/4Mjzj5j... Stitcher: https://www.stitcher.com/show/the-rhe...  TuneIn: https://tunein.com/podcasts/Health--W... Podbean: https://rheumnow.podbean.com/ Got a Rheumatology question or case for Dr. Jack Cush? Record it here and we'll feature it on an upcoming podcast.  Tell us your name and where you practice rheumatology. BackTalk: https://rheumnow.com/submit-podcast-q...

Marvel's Avengers removes their controversial MTX after adding them to the game recently. A new Marvel game gets revealed, and we talk TASM2. Patreon: https://www.patreon.com/joyclicks Twitter: https://www.twitter.com/excelsiorjc Jack: https://www.twitter.com/fascinatedjack Christian: https://www.twitter.com/chun2d2 https://www.tiktok.com/@chun2d2? Special Thanks to our Patreon Producers - Aaron Eastin, Charles Applin

New to RheumNow? Rheumnow.com is a news source dedicated to the field of Rheumatology. It is written by experts in the field, and written for rheumatologists and individuals working in related fields. In this episode, Dr Jack Cush reviews the news, journal articles and FDA warnings from the past week on RheumNow.com A population based Swedish study of birth records shows that antibiotic exposure in first three years of life to be associated with a future risk of JIA, although infections during fetal life or childhood did not increase risk of JIA. #RheumNow https://t.co/Md0zBm5Txl Alendronate may protect against type 2 Diabetes. Data from National Danish Patient Registry, presented at the EASD meeting compared 160k T2DM & 500k controls, T2DM following alendronate adjusted OR=0.64; 0.62-0.66; ⋗8yrs OR=0.47 https://t.co/RYEZodUZtv Analysis of 508 #RA pts (over 10 yrs) in the BeST study shows joint swelling at baseline resulted in half w/ re-swelling later and significantly increased risk of same joint swelling during follow-up (OR 2.37, 95% CI 2.30 to 2.43, p⋖0.001) https://t.co/a7zH4YRAkq Finnish Pop study 939 #RA pts shows highest healthcare costs linked to high Dz activity & comorbidity. Clusters: C1) young w/ low costs & activity, C2) chronic pain, disability, fatigue, C3) high cost/dz activity, less pain, C4)comorbidities w/ $$$ https://t.co/Azc35zyA9J A longitudinal study from Iceland shows an increasing number of native joint infections (NJI), with iatrogenic, postarthroscopic infections being of particular concern. Read more… https://t.co/j3gzZ9g0QV Case controlled study suggests that intraarticular steroid injections is associated with increased (HR 8.56; 3.29-22.3) risk of rapidly destructive hip disease (RDHD); at a rate of 5.4% (5.1 mos post injx) w/ JSN, osteolysis, fem head collapse https://t.co/grX5bO4495 Biosimilar update: 31 FDA approved biosimilars, but only 60% made it to market. 2015 to 2019, drug spending grew 6.1%, biologic spending grew 14.6%; biologics are 43% of US drug spending. Most biosimilars at ~30% discount. https://t.co/4paYH8yVLQ Study Finds U.S. Generic and Biosimilar Savings Totaled a Record $338 Billion in 2020 https://t.co/hPR0nGd6jp Can I get the INFLUENZA and COVID Vaccines together? The CDC says: "YES...both vaccines can be given at the same visit, people should follow the recommended schedule for either vaccine.... ideally get a flu vaccine by the end of October." https://t.co/T49zm6Cxyc MMWR shows the safety of a 3rd (booster) dose of the mRNA vaccine to be same as the 2nd dose AEs. V-safe data on 3rd dose (n=12,591) showed local or systemic effects (79% or 74%) to be same as 2nd dose (78% or 76%) https://t.co/LcD0ARlWJ2 CDC Advises COVID-19 Vaccines for Pregnant Women https://rheumnow.com/news/cdc-advises... U.S. Preventive Services Task Force (USPSTF) reaffirmed its recommendations that pregnant women at a high risk of preeclampsia should take a daily aspirin regimen at the end of the first trimester https://t.co/DiV7p6g8vL Is Acetaminophen Potentially Hazardous in Pregnancy? https://rheumnow.com/news/acetaminoph... #RA patients had an an increased risk of mortality after CABG (HR 1.50; 1.28-1.77); and a higher risk of MI following CABG (HR 1.61; 1.28-2.04). A retrospective Finnish study comparing RA (n= 378) to nonRA patients (n = 7560) https://t.co/cGGsrLs1V2 Early Diastolic Dysfunction in Premenopausal Women with RA https://rheumnow.com/news/early-diast... 108 pts with autoimmune cytopenias (TTP, ITP, AIHA, etc) were given COVID vaccination showing low rate of post-vax flares. Signif HEME decreases in 7.4% of AIHA & ITP; mild decrease in 10% AIHA and 20% ITP, w/ no Rx change https://t.co/OaHILar57z Global SECURE-IBD trial on IBD drugs and COVID shows that severe COVID-19 outcomes were not associated with the use of biologics and mesalamine/sulfasalazine, AZA, 6MP, MTX combo Rx or biologics (TNFi, IL-12/23, IL-23, integrin inhib) https://t.co/MO4i5ngKkr Questions & Cases Approach to dental surgery while on bisphosphonate Recurrent shingles while on adalimumab Myositis after COVID-19 vaccine CONNECT WITH RheumNow ✩ Website - https://rheumnow.com/ ✩ Subscribe @ RheumNow: https://rheumnow.com/user/register ✩ LinkedIn - https://www.linkedin.com/in/john-cush... ✩ RheumNow LinkedIn: https://www.linkedin.com/company/rheu... ✩ Twitter - https://twitter.com/RheumNow Listen | PODCAST Apple Podcasts: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/4Mjzj5j... Stitcher: https://www.stitcher.com/show/the-rhe... TuneIn: https://tunein.com/podcasts/Health--W... Podbean: https://rheumnow.podbean.com/ Got a Rheumatology question or case for Dr. Jack Cush? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. BackTalk: https://rheumnow.com/submit-podcast-q...

Q and a with an Epidemiologist. The host for this show is Minara Mordecai. The guest is Dora Ilyasova. Join us for a conversation with Dora Ilyasova, Ph.D, MSPH, a distinguished public health researcher and epidemiologist with the MTX group. We unpack current research related to COVID-19, such as the benefits of ventilation, co-morbidity factors, and projections for the future of the virus. The ThinkTech YouTube Playlist for this show is https://www.youtube.com/playlist?list=PLQpkwcNJny6ll0bTOmb2IriDyTWwXqKfC

There's nothing like an interview with someone who's always smiling :). Chris was interviewed by Zizaran and Mathil this past week and it was awesome. There were some great questions and answers, which obviously gives Episode 98 lots of content to discuss. (It was so great to see Chris in such a great mood and love the questions.) But we also had some great laughs about Dumb and Dumber, future content, MTX, vacations, sweet QoL patches...time just flew by for us. We hope you enjoy Episode 98 as much as we had making it. Also, happy 4th anniversary Xbox PoE!Forever Exiled Info:www.foreverexiled.comPatreonTwitter @ForeverExiled82Path of Exile WebsiteWrecker of Days Builds ListDiscord...FE Merch StoreFE Nexus StoreAdvertising Inquiries: https://redcircle.com/brands

FDA 批准卡那单抗用于治疗成人Still病Lancet 苏金单抗与阿达木单抗治疗银屑病关节炎的头对头比较Arthri & Rheumatol重组腺苷脱氨酶可改善系统性硬化症模型的纤维化卡那单抗（canakinumab）上周一的心脏科专题中，我们聊到了冠心病的抗炎治疗最新进展，目前研究热点集中在IL-1β单克隆抗体卡那单抗和秋水仙碱。今天我们来聊一聊卡那单抗在免疫科中的应用。卡那单抗（canakinumab）最初于2009年被FDA批准用于治疗Cryopyrin相关周期性综合征（CAPS）、全身型幼年特发性关节炎以及三种少见的周期性发热综合征；2020年6月，卡那单抗被FDA批准用于治疗成人Still病。《卡那单抗用于治疗成人Still病以减少关节炎的表现：2期临床试验》Annals of Rheumatic Diseases，2020年8月 (1)这项多中心、双盲、随机、安慰剂对照试验，旨在评价其治疗成人Still病的有效性和安全性。研究纳入19名多关节受累的成人Still病患者，随机给予卡那单抗和安慰剂治疗。基线时，卡那单抗组和安慰剂组的平均疾病活动评分为5.4和5.3。在卡那单抗组中，61%的患者达到30%应答率，50%的患者达到50%应答率，28%的患者达到70%应答率；而对照组仅为20%、6.7%和0%（p=0.033，0.009和0.049)。卡那单抗组的两名患者经历了严重的不良事件。结论：卡那单抗治疗可改善多项成人Still病的疗效指标。银屑病性关节炎银屑病关节炎（psoriatic arthritis，PsA）是一种与银屑病有关的炎症性肌肉骨骼疾病。主要表现为受累关节疼痛和僵硬，可同时累及周围关节和中轴关节，常呈非对称性分布。70%的关节炎就诊时有银屑病病史，80-90%伴有甲病变。实验室检查没有特征性的变化，类风湿因子（RF）、抗核抗体（ANA）和抗瓜氨酸肽抗体（ACPA）大多呈阴性。《荟萃分析：银屑病关节炎关节外表现的患病率》Rheumatology，2020年9月 (2)研究的目的是评价银屑病关节炎关节外症状的流行情况（肌腱炎、指炎、指甲疾病、葡萄膜炎和炎症性肠病），及其对纵向疾病结局的影响。研究纳入65项研究，共计163 299例银屑病关节炎患者。在进行报道的文献中，肌腱炎平均发病率为30%，指炎平均发病率为25%，甲疾病发病率为60%，葡萄膜炎为3.2%，炎症性肠病3.3%。其中，合并指炎的患者影像学进展的可能性增加。结论：银屑病关节炎患者中，常合并肌腱炎、指炎和甲病；而葡萄膜炎和炎症性肠病不常见。《真实世界：银屑病或银屑病关节炎患者严重感染的风险》Annals of Rheumatic Diseases，2020年2月 (3)研究的目的是使用IL-17、IL-12/23或肿瘤坏死因子（TNF）抑制剂，是否与银屑病或银屑病关节炎患者严重感染风险的增加有关。研究共包括11560个新的治疗事件，9264人年的随访。研究共发现190例严重感染（占治疗期的2%），IL-17和TNF抑制剂的感染发生率相似，而IL-12/23抑制剂则明显降低（风险比0.59）。在曾经使用过生物制剂的患者中，各组感染风险无差异。结论：相对于TNF和IL-17抑制剂，IL-12/23抑制剂可以降低银屑病或银屑病关节炎患者的严重感染的风险。《纵向队列研究：银屑病性关节炎的DAPSA、颈动脉斑块和心血管事件》Annals of Rheumatic Diseases，2020年11月 (4)研究的目的是评价反映银屑病关节炎炎症成分的银屑病关节炎的疾病活动评分（DAPSA）是否能够预测心血管事件，而不依赖于传统的心血管危险因素和亚临床颈动脉粥样硬化。研究纳入189例银屑病关节炎患者，平均年龄48.9岁。平均9.9年的随访后，较高的银屑病关节炎的疾病活动评分与心血管事件的风险增加显著相关（风险比 1.04， p=0.009），在多变量模型中调整所有心血管风险后，这种关联仍然有统计学意义。亚组分析中，调整其他心血管风险后，颈动脉斑块与发生CV事件的风险增加显著相关（风险比 3.42）。结论：较高的DAPSA和CP的存在可以独立预测银屑病关节炎患者的心血管事件事件，这种风险不依赖于传统的心血管疾病风险。小羽点评：银屑病性关节炎不仅累及皮肤、关节，还可能增加感染和心血管疾病的发生风险，在临床实践中，需要对银屑病关节炎的患者进行多个系统的功能进行跟踪和随访。银屑病关节炎的治疗银屑病关节炎中，外周关节炎常使用NSAID治疗；若效果不佳，常采用传统改变病情的抗风湿药物（DMARD），如甲氨蝶呤（MTX）、来氟米特（LEF）；若多个关节侵蚀及功能受限，建议使用生物性DMARD，如TNF抑制剂为一线治疗（依那西普、阿达木单抗、英夫利西单抗、塞妥珠单抗和戈利木单抗）。一种TNF抑制剂无效时，可换用另一种TNF抑制剂；两种TNF抑制剂无效时，可使用IL-17抑制剂（苏金单抗、依奇珠单抗）、IL-12/23抑制剂（优特克单抗）、T细胞共刺激调节因子（阿巴西普）、JAK抑制剂（托法替尼）。累及骶髂关节和脊柱关节、附着点炎时，通常不推荐使用传统DMARD。银屑病关节炎患者一般应避免使用糖皮质激素，因为可能增加红皮病或脓疱型银屑病的几率。《回顾性队列研究：传统合成抗风湿药治疗银屑病性关节炎中，单药保留甲氨蝶呤优于柳氮磺胺吡啶》Rheumatology，2020年8月 (5)比较传统合成抗风湿药物的疗效和使用时间的研究有限，此研究的目的是比较一线传统合成抗风湿药物单药治疗的银屑病关节炎的药物保留和药物保留的预测因子。文章回顾性的研究了首次使用传统抗风湿药物作为单一药物治疗银屑病关节炎的187例患者，主要终点是治疗失败、停止用药或添加另一个抗风湿药物的时间。患者中单药使用甲氨蝶呤共163人，单药使用柳氮磺胺吡啶共21人，平均药物保留事件为31.8个月。其中甲氨蝶呤平均使用34.5个月，柳氮磺胺吡啶平均使用12.0个月（P =0.016）。使用甲氨蝶呤的患者中，随着年龄增长药物保留率逐渐增加。治疗失败的主要原因是无效(52%)和副作用(28%)。结论：在临床实践中，甲氨蝶呤单药治疗银屑病关节炎优于柳氮磺胺吡啶。《GO-DACT研究：治疗银屑病关节炎患者的指炎方面，戈利木单抗联合甲氨蝶呤优于单用甲氨蝶呤》Annals of Rheumatic Diseases，2020年4月 (6)戈利木单抗是一种抗肿瘤坏死因子α单抗，研究的目的是评价戈利木单抗联合甲氨碘呤和单用甲氨蝶呤治疗银屑病性关节炎指炎的疗效。这个多中心、随机、双盲、安慰剂对照、平行设计的3b期试验中，银屑病关节炎伴有活动性指炎的患者被分配到戈利木单抗或安慰剂组，两者均与甲氨蝶呤联合使用。24周后，与甲氨蝶呤单药治疗相比，戈利木单抗联合甲氨蝶呤显著改善指炎的临床症状（指炎严重程度评分变化分别为5和2，p = 0.026）。联合治疗组的指炎严重程度评分改善50%或70%的患者和Leeds指炎指数改善20%、50%或70%的患者比例显著高于单用甲氨蝶呤的患者。结论：戈利木单抗联合甲氨蝶呤作为一线生物抗风湿治疗银屑病指炎优于甲氨蝶呤单药治疗。《荟萃分析：生物制剂对银屑病关节炎患者外周关节影像学进展的影响》Rheumatology，2020年11月 (7)研究的目的是确定生物制剂在预防银屑病关节炎患者、外周关节影像学进展中的有效性。研究包括11项临床试验，涉及5382名患者，9种药物和18种治疗方法。与安慰剂相比，接受生物制剂的患者更有可能实现影像学无进展（优势比2.40，其中TNF抑制剂的优势比 2.94，IL抑制剂的优势比 2.15，阿巴西普的优势比 1.54）。生物制剂显著降低了外周关节影像学进展的风险（影像学进展评分平均下降-2.16，其中TNF抑制剂下降 -2.82，IL抑制剂下降 -1.60，阿巴西普下降 -0.40。生物制剂联合甲氨蝶呤的方案，并不优于单一生物制剂治疗的效果；尤特克单抗和苏金单抗的疗效，不受先前抗TNK治疗的影响。结论：与安慰剂相比，生物制剂可能在骨侵蚀和关节间隙狭窄方面延缓银屑病关节炎患者的影像学进展。甲氨蝶呤似乎没有额外的获益；先前的抗肿瘤坏死因子治疗似乎不会影响IL抑制剂的治疗效果。上一次的节目介绍了IL-17抑制剂（苏金单抗、依奇珠单抗）最近刚刚被FDA批准用于治疗中轴型脊柱关节炎，今天来和大家聊一聊IL-17A单抗在银屑病关节炎中的应用，以及比较这两个药物和肿瘤坏死因子抑制剂阿达木单抗的头对头研究。《Future 5研究：苏金单抗治疗银屑病性关节炎的3期研究结果》Rheumatology，2020年6月 (8)研究目的是评估苏金单抗治疗银屑病性关节炎52周后患者的影像学进展。纳入的银屑病性关节炎参与者，既往没有治疗过、或者TNF-α抑制剂无效，被随机分入苏金单抗 300mg组、150mg组、150mg无负荷给药组或安慰剂组，前4周q1w负荷给药，4周后q4w给药。其中300mg组有91.8%的患者52周后，没有出现影像学进展；在150mg组和150mg无负荷给药组中，这里比例分别是85.2%和87.2%。苏金单抗 300mg组、150mg组和150mg无负荷给药组中，影像学vdH-mTSS评分的随机斜率为-0.18、0.11和-0.20。临床疗效持续稳定，52周内没有报告新的或意料之外的安全事件。结论：苏金单抗 300mg、150mg和150mg无负荷剂量组，治疗银屑病性关节炎显示出持续稳定的低进展率。《SPIRIT-P1研究：依奇珠单抗治疗活动性银屑病关节炎患者的III期临床试验3年结果》Rheumatology，2020年2月 (9)研究的目的是评估长达156周的依奇珠单抗（IL-17A单抗）治疗银屑病关节炎的安全性和有效性。银屑病关节炎患者被随机分配到安慰剂组、阿达木单抗或依奇珠单抗q2w或q4w组。在第24周时，阿达木单抗和安慰剂组的患者被重新随机分配到依奇珠单抗q2w或q4w组，并继续延长治疗至第156周，共243例患者完成了为期3年的研究。依奇珠单抗q2w组患者治疗紧急和严重不良事件的发生率分别为38.0%和5.2%，依奇珠单抗q4w组患者为38.1%和8.0%。156周时，两组患者ACR响应≥20%的比例占69.8%和62.5%；响应≥50%的比例为51.8%和56.1%，响应≥70%的比例为33.4%和43.8%。银屑病面积和严重程度指数（PASI）缓解75%的占（63.5%和69.1）；缓解90%的展51.2%和64.5；缓解100%的占43.6%和60.5%。直至156周，在q2w组中的61%和q4w组中的71%的患者，影像学进展得到抑制。结论：依奇珠单抗治疗156周后，其安全性与之前的报道保持一致，并且观察到银屑病关节炎患者症状和体征的持续改善，包括影像学进展率持续较低。《EXCEED研究：头对头比较苏金单抗与阿达木单抗治疗银屑病关节炎疗效的3b期试验》Lancet，2020年5月 (10)EXCEED研究评估了苏金单抗与阿达木单抗作为一线生物单药治疗活动性银屑病关节炎患者的安全性和有效性。这个平行、双盲、多中心、主动对照的3b阶段的研究，招募18岁以上的、活动性银屑病关节炎患者，主要终点是52周时ACR反应标准至少改善20%（ACR20）。研究过程中853例患者完成了52周的研究，研究结束后，苏金单抗组14%和阿达木单抗组24%的患者选择停止使用研究中的治疗方案。第52周时，67%的苏金单抗组患者和62%的阿达木单抗组患者达到治疗的主要终点，两组间无统计学差异。苏金单抗组2%和阿达木单抗组1%的患者出现严重感染，苏金单抗出现一例与研究药物无关的死亡，其他的安全性与之前报道一致。结论：苏金单抗与阿达木单抗的疗效没有统计学差异，但是苏金单抗的治疗保留率更高。《SPIRIT研究：头对头比较依奇珠单抗和阿达单抗治疗银屑病关节炎的疗效和安全性》Annals of Rheumatic Diseases，2020年7月 (11)SPIRIT研究头对头的比较了依奇珠单抗（IL-17A单抗）和阿达单抗治疗银屑病关节炎的有效性和安全性。 研究纳入566例银屑病关节炎的患者，将患者随机分为依奇珠单抗和阿达单抗治疗组，评价标准是24周和52周时，患者ACR反应标准改善50%（ACR50）和银屑病面积和严重度评分改善100%（PASI100）。52周时，依奇珠单抗治疗组中同时达到ACR50和PASI100的患者的比例显著高于阿达木单抗 (39% vs 26%， p

In this special report, we investigate MTX Group and its founder, Dastagir (Das) Nobel, who won a $295 million contract in early May from the State of Texas for contract tracing.We interviewed two Texas State Representatives, Democrat Joe Deshotel and Republican James White, for reaction. Both had concerns about the bidding process and MTX.Among the findings:- Mr. Nobel claims in his LinkedIn to have completed a Doctorate from Colorado Technical University, but the Registrar's Office at CTU says he did not graduate with a doctoral degree.- Mr. Nobel owned a sushi bar in New York.- MTX Group is in court in the Northern District of New York over a compensation dispute with a former employee who claims he was not paid over $189,000 in commissions.Media inquiries: Please use the email given out in the last minute of the podcast.Subscribe in your favorite podcast app, like our page on Facebook, and subscribe on YouTube!