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The genomic understanding of cancer has transformed a tissue-based classification model that had been dominant for 150 years or more. The last three decades have seen highly targeted therapies developed at blistering pace, and unprecedented improvements in patient outcomes. To date, these advances have been focused on more common cancers. The financing model for drug development means that rare cancers get overlooked, given the small pool of potential buyers relative to the costs and risks of investment. However, the molecular targets characterised in more common cancers are often found in cancers of a different histotype. As such, precision therapies will sometimes have tissue-agnostic efficacy and offer a lifeline for patients with neglected diseases or cancers of unknown origin. Professor David Thomas has founded an NGO called Omico to enable such patients to undergo profiling for hundreds of potential molecular targets. In this interview he explains the rationale for the most promising pan cancer therapies, and in the next episode we discuss changes to the regulatory and funding model required to sustain this screening program. Guest Prof David Thomas FRACP PhD (Director, Centre for Molecular Oncology UNSW; Founder and Chief of Science, Omico) Professor Thomas or Omico have received grants, consultancies or research support from Roche, Astra Zeneca, Pfizer, Eisai, Illumina, Beigene , Elevation Oncology, RedX Pharmaceuticals, SunPharma , Bayer, George Clinical, Novotech , Merck Sharpe and Dohme, Boehringer Ingelheim, Hummingbird, Microba , BioTessellate , PMV Pharma, Australian Unity and Foundation Medicine. ProductionProduced by Mic Cavazzini DPhil. Music licenced from Epidemic Sound includes ‘the Orchard' by Jakob Ahlbom, ‘Dusty Electronics' and ‘Pulse Voyage' by Chill Cole, ‘Tam' by LJ Kruzer, ‘See you soon' and ‘Going Undercover' by Borrtex. Image by filo licenced through Getty Images. Editorial feedback was kindly provided by RACP physicians Nichola Ball, Stephen Bacchi, Aafreen Khalid, Simeon Wong, Maansi Arora and Aidan Tan.Please visit the Pomegranate Health web page for a transcript and supporting references.Login to MyCPD to record listening and reading as a prefilled learning activity. Subscribe to new episode email alerts or search for ‘Pomegranate Health' in Apple Podcasts, Spotify,Castbox or any podcasting app.
This time on Open Stacks we hear from Philip Leventhal, editor at Columbia University Press and veteran Co-opian, about the history of the famous Front Table catalog, in its print and digital forms. Then we head to the Front Table (the actual table) for some recent titles on underground transformation. Philip Leventhal is Senior Editor at Columbia University Press, acquiring titles in Journalism, Film and Media Studies, and Literary Studies. He also worked at the Co-op for many years, and was the managing editor of The Front Table, the Co-op's print catalog and newsletter. Last year we revived The Front Table as a digital publication, featuring bookseller recommendations and notable titles, author interviews, news and numbers from the Co-op, and much more. You can read every issue of the digital Front Table here, and find many of the original print issues on display in the vestibule leading into the Co-op. Thanks to our Children's Marketing Manager, Thulasi, for sharing a passage from Inkheart for this episode, released only a week or so after the re-opening of 57th Street Books for in-person browsing. We'd love to hear something wonderful you've read recently. Find instructions for recording yourself and sharing your reading with us here. Open Stacks is hosted by Alena Jones and produced by Jackson Roach. This episode features music by Blue Dot Sessions, Loyalty Freak Music, Daniel Birch, Joni Void, and LJ Kruzer. Find a list of every book mentioned in this episode here.
When life fades away and death is too shy to step forward, the ROT creeps in... Featuring “Deathless” written by Emma Johnson-Rivard (@finalgirlz) and performed by Lucille Valentine (@severelytrans), Tal Minear (@starplanes), and Shriya Venkatesh; and “After” written by Nicole Calande and performed by Dallas Wheatley (@swheatpodcasts; credited as Sarah Wheatley), Kim E., Taara Rangan, Max George (@CrowleyPhoen) of @ScreamKingsPod, Cole Burkhardt (@Kingcoleminer), Maxx Fidalgo (@genimmax), and VXN (IG @nghm15). Music by Eric Matyas, LJ Kruzer, and frankum. Sound design by Mariel Calande and Cameron Seagraves. Learn more at monstersoutofthecloset.com.
In the penultimate episode of the Chico Enterprise-Record's five-part series on toxic wildfire smoke and its effect on people’s health, host Robin Epley discusses who is studying what the Camp Fire left behind; and what that information means for the future of public health.Follow along at chicoer.com/inhaled for all of our stories.Music by Broke For Free, LJ Kruzer and Chris Zabrinski, courtesy of the Free Music Archive. Our thanks to North State Public Radio for production assistance.
We have a great start to 2018. Fireworks on New Year’s Eve. You and me, and thousands of Canberrans by the lake on a perfect summer’s evening. Life is in control. I have a grant to write a book, Wondery wants the podcast to continue, advertisers are keen, listeners seem keen. I thought I was just about done, but all this has me feeling optimistic. You’re reaching new levels of autonomy, independence, with thoughts, interests and a whole world opening up that has nothing to do with me. You challenge me, you question me, sometimes you know things I don’t know. You have a point of view. You always did in a way, but somehow this is new. Childcare and preschool have prepared you (and me) for Kindergarten. You’re ready. For now, school is exactly where you want to be.I’m at crossroads again. I’ve been heading for it for a while. I need to make a change. I need to finish writing the book. I’ve said most of what I wanted to say in our podcast. I’ve spent almost three years making 34 episodes, it’s almost 16 hours. Our lives as stories, for me, for our family, for all people who chose to listen, but most of all for you. It’s yours Astrid, forever, with all my love. You’re an autonomous person now. It’s time to let you be the custodian of your own story. This is the end of season two. It is time to stop. I predict one or two stray episodes in the future when there’s something worth saying, but more or less, this is it. There won’t be a season three.If this was fiction, we’d have a big ending. Something life-changing. But this isn’t fiction. This isn’t the future. This is real life. This is now.Instead I’ll end with something I can control. This occasion deserves a party!This production is made by me, Sophie Harper, in partnership with Wondery. We’re supported by generous listeners. Story editing by Michelle Webster.Thank you family and friends for letting me share your stories and for all your support. Music from freemusicarchive.org - CC NC License: Charge Into 2015, The Time To Run andThe Stars Are Out (Interlude) by Dexter Britain, Tam8+ei4 by LJ Kruzer and Spellbound by Broke For Free. Ad music from freemusicarchive.org - CC Commercial License: Drop of Water in the Ocean by Broke For Free. Go to www.notbyaccident.net to find out more about the series, to get in touch and join the e-newsletter to hear what we’re up to.I will miss all you listeners. Some have become real world friends, and many more feel like friends to me. I have been so deeply touched my your emails, reviews, voice messages and by your donations. I truely will treasure your words for the rest of my life. I think we both will. And you can know we’re both here, figuring things out, adapting our priorities, sometimes struggling, sometimes succeeding, just living life. Don’t worry, we’re still here in real life. If you’d like to send a one-off donation, go to www.paypal.me/notbyaccident. Thank you so much you amazing people who have supported us on Patreon! Julie Greb, Margaret P. Jones, Trish Perlen, Angela Kim, Emma Burbank, Ellie McHale, Russell Kerrison, Julie Greenhalgh, Rebecca Reid, Kasey Tomkins, Dianne Firth, Anne Staude, Sarah E. Leslie, Adam Coulson, Melanie Ann, Lea Durie, Laura Getson, Bill, Sue Giugni, Maia Bittner, Elizabeth Adcock, Megan O’Brien, Katie Wolgamot, Hannah Lownsbrough, Lilit Asiryan, Laura Madge, Laura Cherry, Bethany White, Paul S Mitchell, Mariele Thadani, Pip Muir, Cynthia Madia and more.Sponsored by Hello Fresh: US listeners, For a total of $60 off, that’s $20 off your first 3 boxes, visit hellofresh.com/accident60 and enter accident60.Thank you so much for listening.
Edward Snowden. Chelsea Manning. Julian Assange. While divisive figures such as these have dominated news cycles and been the subject of fierce debate throughout the last decade, whistleblowing is neither a new phenomenon nor one that is strictly American. Who are some key Canadian whistleblowers? How might the law protect those who disclose? And what is the role of hacking in whistleblowing and what are the effects? Yuan Stevens and Doron Lurie spoke with Prof. Gabriella Coleman to answer these questions and more. Music in this episode: "The Collector" and "Night Owl" by Broke for Free, "Candlepower", "Readers! Do You Read?", and "We Always Thought the Future Would Be Kind of Fun" by Chris Zabriskie, "hydroscope" by Gallery Six, "In the Streets" by Indian Wells, "Chantiers Navals 412" by LJ Kruzer, and "Lips" by Plurabelle.
In 2012 I went home to Australia for Christmas. I had three weeks off from my job teaching documentary filmmaking in Denmark, just enough time to make the trip worthwhile. I wanted to ground myself after a recent break-up and as I came to terms with the fact that really was I was going to try to have a baby on my own, and soon, before it was too late. A couple of weeks after I returned to Denmark to work, I turned 38. I called a clinic and made an appointment to come and talk to them about choosing a donor and getting pregnant. This courage didn’t come from nowhere. I want to take you back to start unravelling some of the events that led to this point. As I approached 30, my mother underwent devastating treatment for advanced lymphatic cancer. She had two years of chemo and nobody thought she would survive. I had a mole on my arm that I’d been worried about for a long time, but a few doctors had told me it was nothing. It wasn’t. It was cancer. Stage two melanoma. My mother had her stem cell transplant days after I had my surgery. I don’t think there’s been a worse week in my family, ever. Then things turned around. My surgery biopsy results came back clear! Her transplant worked! It took some time to build her strength, but she went into remission! Now she has 4 grandchildren who adore her, who we’d had to accept she’d never get to meet. My father and step-mother came to Europe for a holiday just two weeks after my insemination. I hadn’t told them I’d done it yet so wasn’t totally sure how they’d react to this news. They were the first people I spoke the words to with certainty: ‘I did the test again. I’m definitely pregnant!’ Not By Accident is made by me, Sophie Harper. Thanks to my family, my friends and my daughter for allowing me to record, and for the practical and moral support. Please subscribe, rate and review to help the series find more listeners. Go to notbyaccident.net to sign up to my occasional email newsletter, tweet at me @byaccidentnot and if you know anyone who might like to listen, please share! Clips from ABC TV profile of Diana Lampe on Stateline Canberra by journalist Catherine Garrett. Music from freemusicarchive.org - CC NC License: Wednesday by Adrianna Krikl; Disconnect by Adrianna Krikl; Less Than Three by Adrianna Krikl; Tam814 by LJ Kruzer; Tamz by LJ Kruzer; The Stars Are Out by Dexter Britain. US listeners, support the series and eat well. Hello Fresh Has signed on to support me for 2017! Sign up at www.hellofresh.com and use the promo code 'noaccident35' to get $35 off your first delivery. Everybody wins! Go to www.notbyaccident.net to find out more about the series or to get in touch.
This past week, my kids went back to school. Summer vacation has come and gone. And that’s gotten me thinking about the very idea of summer vacation because every summer, for the past several years, my wife, her sisters and our families have had this tradition of going to a cabin for a few days to get out of the city. We don’t own a cabin. We have to rent one. And this year, the process of finding it, looking at pictures of all the possible cabins on all the possible lakes, made me wonder about this particular, middle-class American ritual of going into the wilderness for vacation, where that ritual came from, and what it says about our relationship to modern life. Support Anxious Machine on Patreon Subscribe (or write a review) in iTunes Patrons: Special thanks this week to new Patreon supporter Matt Holliday. Links: Where Was the Birthplace of the American Vacation? Thoreau Leaves Walden Pond Why Fire Makes Us Human Working At Play: A History of Vacations in the United States Music: Gentle Chase by Podington Bear Arrival by North Hive Tam by LJ Kruzer Electron by Podington Bear Halflight by Podington Bear Tamz by LJ Kruzer 88 by Podington Bear
Anyone following the trajectory of London's open-eared Uncharted Audio label will know of Stephen Fiske's work as LJ Kruzer and his propensity for dispensing wonderfully emotive tracks loaded with intricate melodies and lush sonic textures. Son of a Wiltshire vicar, Fiske's formative years were spent listening to his father accompanying hymn singing in church with a Yamaha keyboard — which goes far in explaining his penchant for perky re-rubs of Christmas carols. Since first appearing on vinyl in 2002 (a split EP with The Council Flats of Kingsbury), the London-based producer has released a steady stream of tracks and remixes on Uncharted Audio, AI, Seed and a raft of netlabels. Last year saw the release of his widely lauded second album, Manhood & Electronics, an Eno-inspired masterpiece filled with gorgeous piano treatments, haunting synths and delicate percussive pulses. Uncharted Audio's next release sees four tracks from Manhood & Electronics getting remix treatment from TVO, Trademark, Cyan341 and Ukkonen (info and audio here). To mark the occasion, Spannered is pleased to host an exclusive mix of LJ Kruzer's 'electronic picks', freshly gathered up from the interweb and glued together for your enjoyment. "The mix is the result of an evening spent digging through online mp3 retailers for nice new electronic music. As someone who doesn't consume music in this format — I'm only just catching on to the convenience of CDs! — it was an interesting experience, but not as much fun as going out into the world and hunting and gathering vinyl. The one positive thing about shopping for mp3s online, I suppose, is that it's easier to avoid buying crap music. Not all the tunes on the mix are from mp3 shops — some of them are recent works made or released by musical friends. Anyway, now I have a folder on the family laptop full of new mp3s and nothing to do with them. Do I have to buy an iPod now? Are they even still called iPods...?" LJ Kruzer, February 2010 Tracklisting: Maps+Diagrams – Last Train Home (Yuki Yaki) The Sight Below – Life’s Fading Light (Ghostly International) Reinhard Lakomy – Es wächst das Gras nicht über alles (Permanent Vacation) Asura – Peptine (Non Projects) Aleksi Perala – Sentimenthol (Rephlex) Asura – Asura I (Non Projects) Oneohtrix Point Never – Russian Mind (No Fun) Trademark – Tropic of Capricorn (Intelligent Audio) Isaac Himself – Dad’s Garage (Myuzyk) Erik XVI - Gravitationskraftens stilla vrede [Gravious’ Anti Gravity Mix] (Highpoint Lowlife) Pangaea – Sunset Yellow (Hessle Audio) Grohs – woven lake (unreleased) Klaus Weltman – Albo Th Pigeon Brings A Letter (Strange Life) Ciupy & Mihai Bejenaru – Jewel (Magnetik Grooves) LJ Kruzer – Poil [Cyan341 mix] (Uncharted Audio) Audion – Instant In You (Spectral Sound US) Posthuman – Europa Sky (Uncharted Audio) Reagenz – Du Bist Hier (Workshop) ^ LJ Kruzer's Manhood and Electronics Remixes is out soon ^ LJ Kruzer photograph by Jessica Love