Podcasts about Pfizer

Het is een beetje een saai, ouderwets en gedateerd techbedrijf, maar tóch moet je erop letten, zegt onze gast, Jos Versteeg van InsingerGillisen. Infineon! Een Duits techbedrijf, volgens Jos in de verste verte niet vergelijkbaar met bijvoorbeeld TSMC, daar is de techniek te oud voor. Tóch vindt hij de cijfers interessant, omdat ze chips leveren voor datacenters. Daar hoopt hij meer over te horen. We kijken vooruit op de cijfers, en ook een klein beetje op die van AMD. In Beurs in Zicht stomen we je klaar voor de beursweek die je tegemoet gaat. Want soms zie je door de beursbomen het beursbos niet meer. Dat is verleden tijd! Iedere week vertelt een vriend van de show waar jouw focus moet liggen. Te gast: Jos Versteeg van InsingerGillisen BNR Beurs is een journalistiek onafhankelijke productie, mede mogelijk gemaakt door Saxo. Over de makers: Jelle Maasbach is presentator van BNR Beurs en freelance financieel journalist. Zijn favoriete aandeel om over te praten is Disney, maar daar lijkt hij de enige in te zijn. Sinds de eerste uitzending van BNR Beurs is 'ie er bij. Maxim van Mil is presentator van BNR Beurs en journalist bij BNR, waar hij zich focust op de financiële markten en ontwikkelingen in de tech-wereld. Je krijgt hem het meest enthousiast als hij kan praten over ASML, of oer-Hollandse bedrijven zoals Ahold of ABN Amro. Jorik Simonides is presentator van BNR Beurs, economieredacteur en verslaggever bij BNR. Hij wordt er vooral blij van als het een keer níet over AI gaat. Je hoort hem ook in de BNR-podcast Moerdijk: dorp van de rekening. Milou Brand is presentator van BNR Beurs, freelance podcastmaker en columnist bij het Financieele Dagblad. Jochem Visser is presentator van BNR Beurs, maakt Beursnerd XL en is redacteur bij de podcast Onder Curatoren. Vraag hem naar obscure zaken op financiële markten en hij vertelt je waarom het eigenlijk nóg leuker is dan je al dacht. Over de podcast: Met BNR Beurs ga je altijd voorbereid de nieuwe beursdag in. We praten je in een kleine 25 minuten bij over alle laatste ontwikkelingen op de handelsvloer. We blijven niet alleen bij de AEX of Wall Street, maar vertellen je ook waar nog meer kansen liggen. En we houden het niet bij de cijfers, maar zoeken ook iedere dag voor je naar duiding van scherpe gasten en experts. Of je nu een ervaren belegger bent of net begint met je eerste stappen op de beurs, de podcast biedt waardevolle inzichten voor je beleggingsstrategie. Door de focus op zowel de korte termijn als de lange termijn, helpt BNR Beurs luisteraars om de ruis van de markt te scheiden van de essentie.See omnystudio.com/listener for privacy information.

Please see https://www.pfi.sr/HYMPAVZI_PI for Full PI #HYMPAVZISponsored Mosi Williams, PsyD, lives with hemophilia and has served in  the Bleeding Disorders Community for the past 30 years. He is currently a Licensed  Clinical Social Worker for the UCSF Adult Hemophilia Treatment Center.  Mosi joins Patrick to explore the evolving treatment landscape and the anxiety that  critical moments that shape life with hemophilia—like going back to school, starting a  new job, or planning a wedding—can bring, and how they can prompt deeper  consideration of a treatment change. We'll provide listeners with the latest on HYMPAVZI (marstacimab-hncq) and highlight the value of shared decision-making. HYMPAVZI may cause serious side effects, including blood clots (thromboembolic  events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your  arm, leg, lung, or head, which can be life-threatening. To learn more about this risk and  additional safety information visit www.HYMPAVZI.com.  This post is directed to a U.S. audience and may not be suitable outside of the U.S. This  video is intended to be viewed as it was originally produced in partnership with Pfizer.  Remember, this content is for educational purposes only and does not replace  discussions with a healthcare provider. PP-HYM-USA-1290 Show Notes:  For safety information  visit: https://labeling.pfizer.com/ShowLabeling.aspx?id=20916&Section=PPI  For information on how to navigate your treatment journey, visit the Shared Decision-  making Guide: https://webfiles.pfizer.com/HYM-Shared-Decision  Listen and Subscribe where you get your podcasts! #Hemophilia IMPORTANT SAFETY INFORMATION Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products or "bypassing agents" (products that help blood clot but work in a different way than HYMPAVZI). Your healthcare provider may prescribe factor VIII or factor IX medicines or bypassing agents to treat episodes of breakthrough bleeding during your treatment with HYMPAVZI. Carefully follow your healthcare provider's instructions regarding when to use these medicines and the prescribed dose during your treatment with HYMPAVZI. Do not use additional doses of HYMPAVZI to treat breakthrough bleeds. Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you: have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery. have a severe short-term (acute) illness such as an infection or injury. have been told that you have a risk for blood clots. are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby. Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI. Use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI. are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. If you inject too much HYMPAVZI, call your healthcare provider or the Poison Help Line at 1-800-222-1222 or go to the nearest hospital emergency room right away. What are the possible side effects of HYMPAVZI?  HYMPAVZI may cause serious side effects, including: blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. Blood clots have happened in people using HYMPAVZI. You may have an increased risk of blood clots if you have certain risk factors. Stop using HYMPAVZI and get medical help right away if you develop any of these signs or symptoms of blood clots: swelling or pain in your arms or legs redness or discoloration in your arms or legs shortness of breath pain in chest or upper back fast heart rate cough up blood feeling faint headache numbness in your face eye pain or swelling trouble seeing allergic reactions. HYMPAVZI may cause allergic reactions, including rash and itching. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction: swelling of your face, lips, mouth, or tongue trouble breathing wheezing dizziness or fainting  fast heartbeat or pounding in your chest  sweating The most common side effects of HYMPAVZI include: swelling, hardening, redness, bruising, bleeding, and pain at injection site headache fever joint pain  diarrhea  itching rash  These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. What is HYMPAVZI? HYMPAVZI is a prescription medicine used regularly to prevent or reduce the frequency of bleeding episodes in adults and children 6 years of age and older with: hemophilia A with or without factor VIII inhibitors, or hemophilia B with or without factor IX inhibitors. It is not known if HYMPAVZI is safe and effective in people receiving ongoing Immune Tolerance Induction (ITI).  It is not known if HYMPAVZI is safe and effective in children younger than 6 years of age.

"We have an untapped army of 200,000 PAs that really could step up and drive some change in the healthcare system if we weren't restricted,” says Dr. Jennifer Kolb, capturing her motivation for pushing to update practice regulations for physician associates that date back more than 50 years.  As Chief Medical Officer and Senior Vice President of Clinical Affairs at the American Academy of Physician Associates, Dr. Kolb has been in the middle of the fight at the state and federal level to grant PAs more independence from physicians, full billing rights, and the increased ability to practice across state lines, among other changes.  In this pertinent conversation with Raise the Line host Lindsey Smith, Dr. Kolb explains how these updates could help close huge gaps in access to healthcare, better manage the fight against chronic diseases and improve patient outcomes.   Dr. Kolb also addresses:  Why the name shift from "assistant" to "associate" took her years to fully appreciate; How a 10-year gap in life expectancy across Chicago zip codes shapes her view of health equity; Why PA's shouldn't wait for permission to start making change in their communities. Mentioned in this episode:American Academy of Physician Associates   If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Episode 2866 - In this episode, Ted and Austin Broer connect Fauci's Fifth Amendment invocation before the Senate, a Brownstone Institute report questioning Pfizer's COVID authorization data, Ben Shapiro's Daily Wire 34% company value decline, vitamin D and folate's documented role in muscle mass maintenance, Ozempic's metabolic slowdown consequences, integrative cancer therapy protocols, Lindsey Graham's leaked Netanyahu phone call, and the US weapons stockpile depletion conversation into a broadcast that delivers both urgent health science and sharp institutional and geopolitical accountability.

“Well, this might be unwelcome news,” writes Andrew Yang, “but Kamala Harris is telling people in California that she is running for President again.” Yang, an entrepreneur who ran for President in 2020 as a Democrat, says his sources tell him Kamala's team is quietly laying groundwork for her to run in the next election – and why the DNC announcing that South Carolina “would be the first primary state in the 2028 Democratic primary” is a clue. “She showed up to a political event last weekend that was a pretty clear step in that direction,” says Yang. “As you might be able to tell, I think this whole thing is a disaster.” Andrew Yang joins Dr. Drew to discuss the next big Presidential election, AI's impact on jobs, and why he still champions UBI after famously proposing the Freedom Dividend to grant $1,000 per month to every American adult. Dr. Drew and Andrew also speak about their experience after competing together on FOX's new reality show Nation's Dumbest. Attorney Tom Renz returns to speak about a “betrayal” of MAHA after the CDC “gave Pfizer $1.24 billion for mRNA COVID vaccines including jabs for kids.” Dr. Kelly Victory reports on explosive new details from Dr. Anthony Fauci's COVID-19 diaries, recently released by Sen. Rand Paul in advance of Dr. Fauci's congressional hearing on July 29, 2026. 「 SUPPORT OUR SPONSORS 」 • FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/fatty15⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/paleovalley⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twc.health/drew⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • CHAPTER - For free and unbiased Medicare help, dial (218) 521-2472 to speak with my trusted partner, Chapter, or go to ⁠⁠⁠⁠⁠⁠⁠https://askchapter.org/drdrew⁠⁠⁠⁠⁠⁠⁠ Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. 「 ABOUT THE SHOW 」 This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. Executive Producers • Kaleb Nation - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kalebnation.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • Susan Pinsky - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/firstladyoflove⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Content Producer • Emily Barsh - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/emilytvproducer⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Anthony Fauci will be interrogated today by Senator Rand Paul and colleagues regarding the provenance of the COVID-19 virus and his role in its deadly rampage. The Senator recently disseminated what he describes as the personal diaries of the former medical uber-bureaucrat who was lionized by millions for his purported heroic role in protecting the nation against that disease. The contents include incriminating evidence that “Fauci lied. People died.” This will not be news to those who followed the extraordinary work of Robert F. Kennedy, Jr., Naomi Wolf and the team of volunteers who mined Pfizer's damning internal documents. Ditto the Team B III book entitled China is at War with America which clearly established COVID was a Chinese bioweapon, deliberately sent here to kill Americans.  Let Tony Fauci's long-overdue trial at least in the court of public opinion begin. This is Frank Gaffney.

O governo brasileiro decidiu ampliar a proteção contra a bactéria Streptococcus pneumoniae, ou pneumococo, que causa pneumonia, meningite e outras doenças que podem ser graves. Entre 2023 e 2025, cerca de 1.400 pessoas morreram de meningite no país. Segundo dados do Ministério da Saúde, entre janeiro e abril deste ano, o Brasil também registrou 47.285 casos de pneumonia, um dos maiores aumentos registrados nos últimos anos. Taíssa Stivanin, da RFI em Paris Para reverter essa tendência, o governo disponibilizou a vacina Pneumo 20 (vacina pneumocócica conjugada 20-valente, VPC20) nas unidades básicas de saúde e pontos de vacinação para crianças menores de cinco anos e grupos especiais. Entre eles, povos indígenas sem histórico de vacinação pneumocócica conjugada, idosos a partir de 60 anos acamados e/ou institucionalizados e pessoas com condições clínicas especiais atendidas nos Centros de Referência para Imunobiológicos Especiais (CRIE). A Pneumo 20 substituirá a Pneumo 10, incluída no calendário vacinal infantil em 2010. O novo imunizante amplia a proteção de 10 para 20 sorotipos da bactéria pneumococo e inclui novos sorotipos, como 3, 6A e 19A, que causam doença pneumocócica invasiva. Mais de seis milhões de doses poderão ser disponibilizadas em 2026, de acordo com o governo brasileiro. Disponível na rede privada, o custo do imunizante pode chegar a R$ 600. A obstetra Adriana Ribeiro, diretora médica da Pfizer Brasil, explicou quais são os benefícios da vacina e por que ela apresenta um nível maior de proteção. A executiva é especialista em ginecologia e obstetrícia, com atuação em medicina fetal, tem pós-graduação em gerenciamento de projetos pela Universidade da Califórnia, em Irvine, e está na Pfizer desde 2011. “A PCV10, que era a vacina disponível na rede pública, não oferecia proteção contra dois sorotipos importantes do pneumococo, especialmente os sorotipos 3 e 19. Esses sorotipos estavam associados a mais de 50% das internações pela doença", lembra. O novo imunizante também amplia a proteção contra outros sorotipos prevalentes no país, como 8, 10A, 11A, 12F e 15B, aumentando a cobertura vacinal. Quais são os grupos podem tomar a vacina na rede pública? “É uma vacina que já estava disponível na rede privada e agora também integra a rede pública. No SUS, ela é oferecida para crianças de até 5 anos e para pacientes de risco atendidos pelos Centros de Referência para Imunobiológicos Especiais (CRIE)", explica. Entre esses pacientes estão pessoas com imunidade comprometida, diabetes, hipertensão ou em tratamento oncológico com imunossupressão. Ao todo, mais de 20 condições dão direito à vacinação. "Até então, o sistema público utilizava a vacina PCV10 para criança e a cobertura oferecida pela PCV10 havia caído para cerca de 3%, porque os sorotipos predominantes da bactéria mudaram ao longo do tempo”, explica a executiva. “A vacina cumpriu seu papel, mas deixou de proteger contra os sorotipos que passaram a causar mais casos da doença. Com a introdução da PCV20, essa proteção sobe para cerca de 77%, representando um avanço significativo para a saúde pública.” Vigilância epidemiológica global O laboratório tem acesso a uma vigilância epidemiológica global de vírus e bactérias para antecipar tendências e preparar futuros imunizantes. “À medida que a circulação dos sorotipos muda, novas variantes podem emergir e ganhar relevância epidemiológica. É fundamental manter vigilância constante e estar preparado para desenvolver e incorporar novas vacinas que ampliem a proteção da população contra os sorotipos mais prevalentes.” Essa metodologia faz com que o imunizante seja eficaz em diferentes continentes. A vacina, explica Adriana Ribeiro, é conjugada e protege contra vários tipos de pneumococo ao mesmo tempo. “Em termos simples, é como se houvesse 20 ‘minivacinas' dentro de uma única vacina. Ela utiliza a tecnologia de vacina conjugada conhecida pela comunidade científica”, detalha a diretora médica do laboratório.  Segundo a executiva, essa tecnologia é utilizada pela Pfizer há muitos anos nas vacinas pneumocócicas e tem um histórico consolidado de segurança e eficácia. No caso da PCV20 e de suas versões anteriores, os açúcares da cápsula dos 20 sorotipos do pneumococo são ligados a uma proteína chamada CRM197, uma versão inativada da toxina da difteria. Essa proteína ativa o sistema imunológico e ajuda o organismo a reconhecer melhor os sorotipos, gerando proteção. Adesão da população Nos últimos anos, a adesão vacinal voltou a crescer no Brasil e, após um período de queda, desde 2022 há uma recuperação das coberturas vacinais infantis, segundo dados do Ministério da Saúde. Para a diretora da Pfizer, a disseminação da desinformação contribuiu para esse cenário. Apresentadas com aparência de conteúdo científico, muitas notícias confundem o público. Embora pareçam baseadas em evidências, transmitem informações “falsas ou distorcidas”, ressalta. Esse fenômeno, lembra ela, não é exclusivo do Brasil. O crescimento da desinformação relacionada à saúde e às vacinas, diz, tem sido observado em diversos países e representa um desafio global para as estratégias de imunização e para a confiança da população nas vacinas. “É importante destacar que, para uma vacina ser incorporada ao mercado brasileiro, ela precisa passar por todas as etapas de desenvolvimento clínico e obter aprovação da Agência Nacional de Vigilância Sanitária (Anvisa)”, diz Adriana. A agência, reitera, é reconhecida pelo rigor de seus critérios regulatórios, o que garante que apenas vacinas com segurança e eficácia comprovadas sejam disponibilizadas à população. Esse processo contribuiu para a recuperação das coberturas vacinais observada nos últimos anos. No caso da vacina pneumocócica, por exemplo, o país já possui uma tradição consolidada de vacinação, o que favorece altas taxas de adesão. “Ao mesmo tempo, é fundamental que a população não apenas mantenha o calendário vacinal em dia, mas também esteja atenta às vacinas que exigem reforços ou revacinação ao longo da vida. É o caso, por exemplo, da vacina contra o tétano e de imunizantes recomendados em fases específicas, como a gestação." Em diferentes momentos da vida, é importante verificar a situação vacinal e atualizar a proteção quando necessário. A ampliação da cobertura depende tanto do acesso às vacinas quanto da oferta de informações confiáveis. Por isso, o combate à desinformação continua sendo um trabalho essencial e coletivo para fortalecer a confiança da população na vacinação.

A new batch of tariffs went into effect overnight. And there's more to come as the Trump administration attempts to rebuild the tariff wall torn down by a Supreme Court ruling earlier this year. This morning, we'll explain the fresh import duties, their exceptions, as well as an ongoing tariff investigation. Plus, support beams inside a former office tower in New York City that is being converted to apartments buckled recently. What does this mean for other office conversions?Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace Morning Report is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.Stories from this episode:What the near collapse of NYC's Pfizer building means for office conversions

A new batch of tariffs went into effect overnight. And there's more to come as the Trump administration attempts to rebuild the tariff wall torn down by a Supreme Court ruling earlier this year. This morning, we'll explain the fresh import duties, their exceptions, as well as an ongoing tariff investigation. Plus, support beams inside a former office tower in New York City that is being converted to apartments buckled recently. What does this mean for other office conversions?Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace Morning Report is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.Stories from this episode:What the near collapse of NYC's Pfizer building means for office conversions

Most adults who smoke want to quit, and about half try to do so in any given year, yet fewer than one in ten succeed. That persistent gap between intention and outcome is one of the central challenges in public health, and it's exactly the kind of problem that calls for new thinking about how to communicate with people to support behavior change.  Dr. Amanda Graham has been a leading force in doing just that in her role as chief health officer at Truth Initiative, the nation's largest non-profit public health organization dedicated to preventing addiction among young people and helping people of all ages to quit tobacco. On this episode of Raise the Line from Elsevier, Dr. Graham, who holds a PhD in clinical health psychology and has done 25 years of NIH-funded research focused on technology-based cessation interventions, helps us understand the interplay between behavioral science and digital communications in the field. "A well-timed message can really be powerful in interrupting what for many people is kind of an automatic behavior, especially via text, which data tell us is an extraordinarily powerful modality,” she explains to host Lindsey Smith.  Tune-in to understand where the field is heading, and to learn about: Why "push" technology may work better than apps and websites when it comes to breaking automatic behaviors; How the rise of e-cigarettes, nicotine pouches, and heated tobacco has scrambled decades of public health messaging; How highschool smoking rates plunged from over 30% to less than 2%. Mentioned in this episode: Truth Initiative Program with Mayo Clinic If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Synopsis: In an industry often defined by rapid innovation and high-stakes science, long-term success in biotech requires more than breakthrough discoveries—it demands strategic clarity, resilient leadership, and a deep understanding of unmet patient needs. In this engaging conversation, Rahul Chaturvedi sits down with Robert Jacks, President & CEO of Sparrow Pharmaceuticals, to explore his unconventional journey from civil engineering to biotech leadership, the lessons learned from building and exiting successful companies, and why creating lasting value should take precedence over chasing acquisitions. Robert reflects on his career spanning Pfizer, entrepreneurship, venture capital at OrbiMed, and leading multiple biotech companies, sharing how his experiences shaped his approach to leadership, capital allocation, and company building. He explains why influence matters more than authority, how empathy creates stronger organizations, and why keeping biotech companies lean allows them to remain resilient throughout unpredictable funding cycles. The conversation then explores Sparrow Pharmaceuticals' evolution from a rare disease company into a precision medicine leader focused on difficult-to-control type 2 diabetes. Robert provides an in-depth look at the emerging science behind cortisol biology, HSD1 inhibition, and why excess intracellular cortisol may represent one of the industry's most overlooked drivers of metabolic disease. He also discusses Sparrow's recent clinical data, the rationale behind its strategic pivot, the future of patient stratification in cardiometabolic disease, and how Sparrow aims to complement—not compete with—the rapidly expanding GLP-1 landscape. From fundraising and leadership philosophy to clinical development strategy and the next frontier of precision medicine, this episode offers practical insights for biotech founders, investors, and industry leaders navigating the complexities of building enduring biotech companies. Biography: Robert has 25 years of experience in the biopharmaceutical industry. He has founded or co-founded multiple companies and raised more than $300 million. Previously, Robert was the President & CEO of Indalo Therapeutics, a clinical-stage biotechnology company developing therapeutics for serious fibrotic diseases, and President, CFO, and Co-Founder of Symbiomix Therapeutics, which was sold after achieving NDA approval for Solosec®. Robert also previously held the positions of Head of Corporate Development for Tobira Therapeutics, Head of Business Development for ACT Biotech, and Entrepreneur-in-Residence for OrbiMed Advisors. Robert began his pharmaceutical industry career in finance and product development at Pfizer, where he last worked as the Director of Business Development for Oncology and Infectious Diseases. Robert earned an MBA from Columbia Business School, an MSE in Civil Engineering from Stanford University, and a BSE in Civil Engineering from Duke University. When not solving intractable healthcare problems, Robert spends as much time as possible with his two daughters.

AUA2026: Focus on: Muscle Invasive Bladder Cancer CME Available: https://cme.auanet.org/URL/FOCUS266ONL LEARNING OBJECTIVES: After participating in this CME activity, participants will be able to: 1. Evaluate limitations in the current MIBC treatment landscape including patient outcomes and gaps in available systemic therapies to identify individuals with limited or no effective treatment options and enhance clinical decision-making. 2. Interpret the mechanisms of action and clinical data supporting antibody-drug conjugates (ADCs) to determine their potential role in addressing unmet therapeutic needs in patients with MIBC who are ineligible for traditional treatment pathways. 3. Incorporate evidence-based perioperative systemic treatment strategies including neoadjuvant and adjuvant approaches into patient care algorithms to improve pathologic response rates and survival outcomes in MIBC. 4. Apply best practices for managing and mitigating adverse events associated with emerging systemic and perioperative therapies to optimize treatment adherence and patient safety in the MIBC setting. 5. Implement strategies for effective communication, multidisciplinary care coordination, and shared decision-making between urologists, medical oncologists, and patients to improve treatment alignment and patient-centered outcomes in MIBC. ACKNOWLEDGEMENTS: Support provided by an independent educational grant from: Pfizer, Inc.

Guests: John Kolm, CEO,Team Results USA, Former Australian Intelligence Officer, Best selling author of Crocodile Charlie & The Holy Grail and international cartoonist. Troy "Bucket" Orwan, USAF Lt. Col. (Ret.), Electronic Warfare Officer John and Troy are experts in Simulation Training employed in the military and various governmental agencies. Team Results USA applies this training to all business environments, sizes, and industries. BIOS: John Kolm is CEO of Team Results USA, an organization that helps leaders and teams perform under pressure through immersive, experience-based simulations. Before founding the company, he served as a senior intelligence officer with the National Security Agency, bringing decades of experience in leadership, decision-making, and high-stakes operations. He is also the best-selling author of Crocodile Charlie and the Holy Grail and a frequent speaker on leadership, teamwork, and the impact of artificial intelligence in the workplace. He began developing Simulations in the intelligence community as a method of training field staff, and is an industry leader in this field for organizations including Toyota, IBM, Pfizer and the State Department. Colonel Troy Orwan, callsign “Bucket”, U.S. Air Force (Ret.), is a communications and spectrum technology expert with decades of experience spanning government, defense, and private industry. During his 24-year Air Force career, he developed extensive expertise in electronic warfare, tactical aviation, and wireless communications. Throughout his career, he has advised on complex issues involving spectrum management, emerging technologies, and national security. He joins us today to discuss the future of wireless spectrum and its growing importance to both our economy and our national defense. Bucket is also a former military aviator with extensive experience in Simulation and its usefulness for developing people professionally, both inside and outside the Air Force.See omnystudio.com/listener for privacy information.

A few days ago I reported on the structural failure at the former Pfizer headquarters at 235 East 42nd Street in Manhattan. Late last week we learned a few more details. The structural engineer on the project has now publicly stated that the reinforcing steel specified in the construction drawings was apparently never installed on the two columns that ultimately buckled.If that statement ultimately proves to be correct, then this wasn't a design failure.It was an execution failure.The columns in question are made of steel. They are made of structural steel that looks like an I beam, except it is vertical instead of horizontal. The engineer called for steel plates to be welded to the sides of each beam in order to create a box beam out of the I-beam profile. This was not done. The photos of the failed columns clearly show the original columns with no welded plates. I've looked at the detail on the structural drawings which clearly show the treatment for four different types of columns. The columns near the exterior are the ones in question. That makes me ask a different question.How did this get past everyone?Now, I want to be careful.The official investigation is still underway. The Department of Buildings, the Department of Investigation and independent forensic engineers are all examining what happened, and no final conclusions have been reached. The city has also expanded inspections to other projects involving the same developer and inspection firm while investigators determine whether broader quality-control issues exist.But regardless of where responsibility ultimately lands, this incident exposes something much larger.A gap in quality assurance.Quality assurance isn't glamorous. Nobody celebrates it. Nobody gets awards for finding problems before they become disasters. But every high-reliability industry depends on it.Software isn't shipped without testing.Aircraft aren't delivered without  every component undergoing inspection and certification.Automobiles undergo extensive inspection on the factory floor before they're ever sold.As you think about that, ask yourself one simple question.In your own business, where are you relying on assumptions instead of verification?-----------**Real Estate Espresso Podcast:** Spotify: [The Real Estate Espresso Podcast](https://open.spotify.com/show/3GvtwRmTq4r3es8cbw8jW0?si=c75ea506a6694ef1)   iTunes: [The Real Estate Espresso Podcast](https://podcasts.apple.com/ca/podcast/the-real-estate-espresso-podcast/id1340482613)   Website: [www.victorjm.com](http://www.victorjm.com)   LinkedIn: [Victor Menasce](http://www.linkedin.com/in/vmenasce)   YouTube: [The Real Estate Espresso Podcast](http://www.youtube.com/@victorjmenasce6734)   Facebook: [www.facebook.com/realestateespresso](http://www.facebook.com/realestateespresso)   Email: [podcast@victorjm.com](mailto:podcast@victorjm.com)  **Y Street Capital:** Website: [www.ystreetcapital.com](http://www.ystreetcapital.com)   Facebook: [www.facebook.com/YStreetCapital](https://www.facebook.com/YStreetCapital)   Instagram: [@ystreetcapital](http://www.instagram.com/ystreetcapital)  

In this episode of “Redefining Global Health in the 21st Century,” Ben speaks with authors Dr. mike Reed and Professor Eric Goosby about how COVID exposed the geopolitical ramifications of Global Health, using Serbia's vaccine deals with China, Russia, Pfizer, and AstraZeneca as a case study. They argue the era of a single global health superpower is fading and discuss a multipolar future shaped by “middle powers,” alongside the consequences of the US stepping back from traditional global health commitments, including leaving the WHO. The conversation critiques bureaucratic, duplicative governance and vaccine inequity, examines China's largely transactional health role and the limited donor potential of the BRICS nations, and warns that the US defunding of South Africa's HIV program harms HIV research more broadly. They call for stronger WHO implementation and decentralized rapid-response capacity, greater accountability, and less credit-seeking, while condemning tying lifesaving aid to transactional commercial arrangements, for example access to minerals and other commodities. 00:00 Serbia Vaccine Surprise 01:45 Multipolar Health Governance 05:04 US Retreat and Local Ownership 08:33 Why WHO Faces Critique 11:08 China Steps Into the Gap 17:04 BRICS Limits and Leverage 22:15 South Africa Research Stakes 24:54 WHO Reform and Decentralization 34:36 WHO Beyond Guidelines 36:29 Pandemic Governance Gaps 38:36 Climate Zoonoses Preparedness 39:45 Trust And Fragmentation 42:01 Rapid Response Blueprint 45:38 Inclusive Accountable Governance 49:36 Post Aid Future Financing 52:53 Hard Power Moral Costs 58:54 New Compact Conclusion 59:48 Humble Leadership Lessons 01:03:01 Thanks And Where To Listen Learn more about the book: https://bit.ly/redefining-global-health More from UCSF Institute for Global Health Sciences: https://globalhealthsciences.ucsf.edu Check out mike Reid's Substack: https://substack.com/@reimaginingglobalhealth Check out Ben's Substack: https://substack.com/@benplumley1 Join the Conversation! What would it take for global health to avoid decline? Share your thoughts in the comments! Subscribe & Stay Updated: Listen on Spotify, Apple Podcasts, or your favorite podcast platform. Watch on YouTube & subscribe for more in-depth global health — and look out for a dedicated sub channel for Redefining Global Health in the 21st Century under A Shot in the Arm's YouTube home. Redefining Global Health in the 21st Century: The Podcast (Playlist on Youtube) https://bit.ly/rgh-podcast A Shot in the Arm Podcast Youtube (Main Channel) https://youtube.com/@shotarmpodcast

Why Your Stroke May Not Be Causing Your Brain Fatigue For a long time after my brain surgery, I assumed my body worked like this: the stroke happened in my head, so whatever went wrong afterward would also happen in my head. Fatigue, brain fog, slow thinking all of it filed under “neurological,” all of it explained by the injury I already knew about. That assumption turned out to be wrong, and the way I found out was almost accidental. About eighteen months after my brain surgery, I had thyroid surgery to remove a nodule so large it had pushed my windpipe and esophagus six centimeters out of place. I had no idea it was there. No lump I could see, no difficulty swallowing or breathing that I’d noticed. It was found only because I had a chest X-ray to rule out an infection, and a doctor spotted something that had nothing to do with why I’d walked in. What followed was a slow, confusing recovery from that second surgery, and a wave of fatigue I automatically blamed on my brain, because that was the injury I already understood. It took time to realize the fatigue might be coming from somewhere else entirely: my thyroid. Hormones and Stroke Recovery: The Connection Nobody Talks About I brought this experience to Dr. Robert Hedaya, a Clinical Professor of Psychiatry at Georgetown University Medical Center and a pioneer of functional medicine psychiatry, to understand what actually happened, and to ask a bigger question: how many other stroke survivors are dealing with fatigue, brain fog, or mood changes that they’ve written off as “just the stroke,” when the real driver is a hormonal system that’s quietly stopped working properly? Hormones and stroke recovery turn out to be far more entangled than most of us are told. As Dr. Hedaya put it plainly: the brain is a hormonal organ. Thyroid hormone, cortisol, testosterone, estrogen every one of them acts directly on brain tissue, and every one of them can be knocked off balance by the stress of a major medical event. Why “Normal” Thyroid Bloodwork Can Still Mean Something’s Wrong One of the most important things Dr. Hedaya explained is that a “normal” TSH result doesn’t rule out a thyroid problem, especially after a stroke. TSH is a signal sent from the pituitary gland, and if a stroke has affected the brain’s signaling pathways, the pituitary itself may not respond the way it should. A survivor can have genuinely low thyroid hormone while their TSH sits comfortably inside the standard reference range, because the system responsible for raising that number in response to a deficiency isn’t functioning correctly. He also raised a striking data point: population studies suggest the average TSH in a healthy population is closer to 1.4, yet most labs still use an upper reference limit of 4.5, a range wide enough, statistically, to miss a real problem. His advice for survivors going into a GP appointment: ask specifically for TSH, free T4, free T3, and reverse T3, not just the standard single-marker test, and come prepared with symptoms written down if a doctor pushes back. A Nodule That Grew in Silence The brain is a hormonal organ. It’s an immune organ. It’s a neurological organ… there’s not one hormonal axis when it’s abnormal that cannot cause neurological or psychiatric problems. -Dr. Robert Hedaya My own nodule is a case study in exactly this kind of silent progression. Dr. Hedaya explained that because it grew inward rather than outward, it never created the visible lump most people associate with a thyroid problem, and because it didn’t press on my vocal cords or laryngeal nerve, I never developed the hoarseness that might have flagged it sooner. My body adapted gradually, and the fatigue that eventually surfaced was easy to misattribute to the injury I already knew I had. Cortisol, Stress, and the Difference Between Pain and Suffering Beyond the thyroid, Dr. Hedaya walked through the role of cortisol, the body’s primary stress hormone, and why survivors often struggle to answer a deceptively simple question: “Are you stressed?” His distinction between pain and suffering is worth sitting with: pain is often unavoidable, but suffering is shaped by the story we tell ourselves about a situation, and a stroke can compromise the very brain systems that regulate that stress response in the first place. Testosterone, Estrogen, and the Brain’s Need for Hormones to Rewire The conversation closed on sex hormones, testosterone and estrogen, relevant to both men and women, and their role in neuroplasticity. Dr. Hedaya drew a direct comparison to adolescence: the teenage brain rewires itself while hormone levels are surging, and the same principle applies after a stroke. A brain trying to rebuild pathways needs adequate hormonal support to do that work. Without it, recovery can stall in ways that have nothing to do with effort or physiotherapy. What You Can Do About It If any of this sounds familiar fatigue that doesn’t track cleanly with other recovery milestones, or symptoms a doctor has waved off as “just stress,” Dr. Hedaya’s PNIE (psycho-neuro-immuno-endocrinology) questionnaire is a useful starting point. PNIE Questionnaire download: https://drive.google.com/file/d/1S7kC5uMFgBfS-gWcUOIHp0kOjGnrzZK5/view?usp=sharing If thyroid function specifically is what you’re navigating, the earlier conversation with Dr. Elena Zinkov, “Stroke Fatigue and Thyroid,” goes deeper into that piece (https://recoveryafterstroke.com/stroke-fatigue-and-thyroid/). And for more from Dr. Hedaya, the first conversation on photobiomodulation and stroke recovery is a good companion listen (https://recoveryafterstroke.com/photobiomodulation-stroke-recovery/). Getting your body back after a stroke is rarely just about the brain. My book, The Unexpected Way That A Stroke Became The Best Thing That Happened, goes further into the mindset shifts that came out of my own recovery (recoveryafterstroke.com/book). And if this podcast has helped you, you can support its continuation at patreon.com/recoveryafterstroke. This blog is for informational purposes only and does not constitute medical advice. Please consult your doctor before making any changes to your health or recovery plan. Hormones, Fatigue, and the Brain: Dr. Robert Hedaya Returns (Interview) A baseball-sized thyroid nodule hid in plain sight after Bill’s stroke. Dr. Hedaya explains the hormone testing every survivor should ask for. Support The Recovery After Stroke Podcast Bill’s Book: The Unexpected Way That a Stroke Became Thethe Best Thing That Happened Highlights: 01:45 Hormones and Stroke Recovery 02:11 Understanding Thyroid Function and Its Impact 17:07 Navigating Thyroid Health with Healthcare Providers 27:09 The Role of Stress and Cortisol 39:09 Nutrition’s Impact on Brain Recovery Transcript: Hormones and Stroke Recovery Bill Gasiamis (00:00) And they noticed a massive lump in my throat and my esophagus and my windpipe were pushed six centimeters. And they said to me, well, can you swallow? Can you breathe? Can you do it? And I was like, yeah, I’m all fine. There’s nothing wrong with my throat. that was the first sign that there was something wrong with my thyroid Bill Gasiamis (00:19) Welcome back to Recovery After Stroke. I’m Bill Garciamas, and today I’m joined again by Dr. Robert Hedeya, clinical professor of psychiatry at Georgetown University Medical Center and a pioneer of functional medicine psychiatry, whose highland approach to brain health first brought him onto the show for our conversation on episode 404, where we discussed, amongst other things, photobiomodulation, a type of transcript. cranial laser therapy helping some stroke survivors recover lost function. He’s back today for a conversation I wanted to have for a while, the hormonal side of stroke recovery. We’re going to talk about thyroid function, cortisol, and stress physiology, and sex hormones like testosterone and estrogen, and why every one of these systems can directly affect how well and how fast your brain recovers. I’ll also share my own story of a thyroid nodule that grew undetected, which was discovered after my brain surgery completely by accident. if this conversation resonates with you, my book, The Unexpected Way That a Stroke Became Thethe Best Thing That Happened goes deeper into the mindset shifts that shaped my own recovery. You can find it at recoveryafterstroke.com/book. And if you’d like to help keep this podcast going, you can support it financially at patreon.com/recoveryafterstroke. Bill Gasiamis (01:46) Robert Hedaya, welcome back to the podcast. Dr Hedaya (01:49) Thank you for having me, Bill. Understanding Thyroid Function and Its Impact Bill Gasiamis (01:51) thank you for being here. The last conversation we had was very well received. And it’s always difficult in a one hour interview to ask all the questions that we could possibly ask about the brain and stroke recovery and all the things that people go through. And… I’ve got a lot of other questions that are related to the brain and the link between other parts of the body and the brain, because we have this sense. Well, I did at least when I was first diagnosed that whatever happens in my head is kind of isolated, that it just impacts my head. But there seemed to be some other impacts and cascading effects. that were occurring, uh, that I didn’t know were linked to the brain injury, Dr Hedaya (02:45) Yeah. Bill Gasiamis (02:46) maybe indirectly, but they were perhaps. But one thing specifically that happened to me about, uh, 18 months after my brain surgery was I had thyroid surgery to remove a nodule on my thyroid. And when I was going through the recovery after that, surgery, I noticed that I had fatigue and I thought it was neurological fatigue related to my brain surgery. But it took a long time to develop an understanding that perhaps that batch of fatigue was related to my thyroid. And then that got me thinking all sorts of things. know, if the thyroid also causes the same neurological fatigue that brain injury causes, what people might be missing this in their healing from a brain injury, they might have a compromised thyroid and not know about it. So the first question is, what is a thyroid? What does it do? And why does it cause neurological fatigue? Dr Hedaya (03:54) Okay. So thyroid gland sits in the neck, right? There’s two lobes, there’s one on the right, one on the left, a little kind of island in the middle called the isthmus, and and it controls many functions, metabolism overall, energy overall, just broadly speaking. now it affects the immune system. It’s affects the nervous system. It affects the gastrointestinal system, it affects the muscles, it affects the heart, right? It affects the skin, it affects the nails, it affects the hair. You know, and I could go on and on and on. Okay? Bill Gasiamis (04:34) Wow. Dr Hedaya (04:35) Now the interesting thing about this is that this be a little technical, but the thyroid puts out a hormone called T4 or thyroxine, and this is a little molecule with four iodines in it on it, and that Gives you about 20% of the activity of your thyroid hormones in your body. But then that T4 goes all over the body to different tissues, and each tissue can has its own system to change that T4 into T3 by removing an iodine. T3 has 80% of the thyroid activity. So that means each tissue in the body can control how much thyroid it. It’s using and needs, right? And and has available to it. Okay. So that means the brain, the heart, the liver, the lungs, every tissue has its own enzyme that allows it to kind of modulate how much thyroid, right? Now, so why does that cause neurological fatigue? Well, thyroid in the brain affects neurotransmitters like adrenaline in the brain, which is called nor norepinephrine, noradrenaline. in order for that to work. The T3 has to be in the right amount for the receptors for the noradrenaline to be structurally correct so they can transmit the signal. It’s necessary for production of energy in all the brain cells. It helps the immune system in the brain. It carries molecules from here to there in the brain. it affects serotonin transmission in the brain, so mood regulation, anxiety, obsessiveness, depression. You know, those are just some of the functions of the brain, but it affects every cell in the bane in the brain. So you’re gonna, if your thyroid is off, most likely you’re gonna have some kind of brain problems, particularly, you know, when your thyroid is off, the tissues in your body that are most compromised or most stressed, that’s probably where it’s gonna show up, right? And in the case of stroke, that’s where it’ll show up. Bill Gasiamis (06:44) So it’s possible then, is it possible to overlook it? Is it very obvious that your thyroid is out of, well, is dysregulated or is not working properly? Dr Hedaya (06:56) Well, in general it’s easy to detect. And if you want, I’ll tell you how. So Bill Gasiamis (07:04) Yeah. Tell me how. Dr Hedaya (07:07) so there’s some blood tests that are simple and then s some symptoms. so for most people this holds. When your thyroid is low, you know, you’re gonna be cold easily, you’re gonna have dry skin, brittle nails, hair will fall out. Muscles will be weak, thinking will be slow, movement will be slow, getting up from a chair will be more difficult, going upstairs will be more difficult, your heart rate will slow down, you’ll be constipated. Those are the most common symptoms. If your thyroid is overactive, then you could be have palpitations, oily skin, acne, oily hair. Diarrhea, you know, kind of the opposite. The thing that’s a little confusing with the thyroid is sometimes overactive thyroid can show up and look like it’s underactive symptomatically, or vice versa. So you really need the labs. And the labs are TSH, which is thyroid stimulating hormone, and that’s tells you what the brain is doing. And then free T4. That’s the amount of T4 that’s kind of floating around free, not bound to protein, so it can actually do its job. The way I think of it is like, you know, a lot of the thyroid home is sitting on a bus. It’s not free, it’s bound to protein. Can’t do its job. But the stuff the thyroid this that’s out of the bus or not on a protein, that can do its job. That’s the free T four. And then the free T three, right, which carries eighty percent of thyroid activity. And then the last one is a reverse T3 because sometimes if your tissues in your body are making too much thyroid or getting too much thyroid, they’ll actually, instead of taking the iodine off the T4 molecule on the right side, they’ll take it off on the left side, or vice versa. So they make a fake T3 that doesn’t work. And this way they short circuited okay, you got all this T3. Well, let’s make it into a fake, fake T3 so it can’t do anything. So reverse T3 is also very important. And then you want to measure body temperature. Usually it’ll be low. And then, you know, a physical exam. Those are the ways to do it. If you wanted to go even deeper, you could do some genetic testing. There are genes that will tell you whether you’re converting the T4 to T3 in the brain. Adequately, or maybe you’re more likely to be slow in that regard. So you can have normal numbers in your blood, but your brain might be hypothyroid, right? And there are actually a lot Bill Gasiamis (10:05) Uh-huh. Dr Hedaya (10:05) of studies showing that hypermetabolic, like high doses of free T3, actually reverse treatment-resistant depression because it’s it’s thought that there’s a local in-brain. hypo-low thyroidism. You can have low thyroidism in your heart, in your muscles, but not in the other tissues, you know, because I told you every tissue can control how much it’s making. So if you have a genetic vulnerability, then you you might more be in general be more likely vulnerable to depression or to ADD or to anxiety, things like that. Bill Gasiamis (10:42) Wow. Are you blowing me away? I didn’t expect to hear any of the things that you just said. X. Um, some of the things that you described, the, uh, some of the symptoms that you described, had those intermittently in and out all the time, other than a thyroid nodule, which is what I had, which was obvious on a scan. Dr Hedaya (11:05) Yeah. Bill Gasiamis (11:06) What other things caused the thyroid to not function? correctly. So is there lifestyle factors that interfere with the thyroid gland and therefore, you know, then have the cascading effect and take off, take all those other things or some of those other things offline. Dr Hedaya (11:28) So there a number of causes, right? So first of all, let’s take someone who has had a stroke or chronic illness, right? So you’re under stress and that affects your stress hormones, your adrenal glands, cortisol, etc. Well, if your adrenals kind of poop out, then maybe your body says, Well, I can’t handle all this thyroid, even though the amount is normal, it’s like too much. I can’t handle it, so it’ll make less thyroids. Now you develop a hypothyroidism. You could develop it just because all the chemicals in the environment, the ha the hormone interrupting chemicals, there are hundreds of those. you could develop it ’cause of nutritional deficiencies like tyrosine is necessary to make thyroid hormone, copper, you know, things like that. I can’t tell you offhand which which nutritional factors, but people can look that up, what nutritional factors are important. To make thyroid hormone. and then infections like, for example, Lyme disease causes Hashimoto’s thyroiditis, which is an autoimmune where your immune system’s actually attacking your thyroid. COVID vaccination, like the Pfizer and the Moderna vaccine, if you are genetically vulnerable, can also cause your immune system to attack your thyroid. So there are many, many causes, plus there are inherited genetic vulnerabilities and it It’s not always low thyroid, sometimes it’s high thyroid, hyperthyroidism, like Graves’ disease, right? You can have antibodies Bill Gasiamis (13:01) Mm-hmm. Dr Hedaya (13:02) that are actually stimulating thyroid activity as well. Bill Gasiamis (13:06) Wow. The environmental toxins. we talking about all day, every day household use kind of environmental toxins? I imagine the external of the house, they’re kind of out of our control, right? We’ll talk about like, you know, like pollution or things that are associated to things that are caused that we don’t necessarily control, but internally inside the house or what we expose ourselves to that we can control. what would some of those environmental toxins Dr Hedaya (13:38) Well Bill Gasiamis (13:39) be? Dr Hedaya (13:40) so for example, you know, in your produce, you know, there are pesticides, or in the man made materials in your car or the man made materials in your home. Let’s say you bought a new home and you have, you know, some kind of synthetic floors or furniture with synthetic materials or materials that are natural that are treated with chemicals for various reasons. Those things all can be not everyone is, but many of them are called homes. hormone interruptors because they actually can change the way your hormones function. You know? So we’re the truth is we’re bathed in these chemicals. They’re everywhere. And very hard to escape them. The best thing you can do is kind of try to detox them using a healthy diet, a lot of crucifer vegetables and lots of vegetables, above ground vegetables that are grown in healthy soil. Without pesticides, organic preferably, right? and then there are supplements you can take, such as metagenics makes something called UltraClear Plus, which helps support the liver, and its detox functions. You know, some people are more vulnerable than others, but you know, these thyroid nodules you like you have, they’re very, very common now. Very common. And that’s you know. In large measure, I think these hormone interrupters that are interfering with how the the thyroid follicles in the thyroid gland are operating. Bill Gasiamis (15:13) Is it possible to have thyroid nodules and not know about it? I, I Dr Hedaya (15:18) Yeah. Bill Gasiamis (15:19) say that because I had nodules that were the size of a baseball, apparently in my throat that were growing inwards, that didn’t make a lump outside of my throat, which Dr Hedaya (15:33) Yeah. Bill Gasiamis (15:34) I was not aware of. And the way they found it was they did a chest X-ray after brain surgery because I wasn’t recovering well. to check my chest to see if there’s an infection. And they noticed a massive lump in my throat and my esophagus and my windpipe were pushed six centimeters. Dr Hedaya (15:52) Wow. Bill Gasiamis (15:53) I’m not sure what that is in inches. And they said to me, well, can you swallow? Can you breathe? Can you do it? And I was like, yeah, I’m all fine. There’s nothing wrong with my throat. But that was the first sign that there was something wrong with my thyroid before that. there was no sign of it. I ask that because either I’m totally oblivious or it is possible to have thyroid nodules and not know it. Dr Hedaya (16:23) Well, most people don’t know it. Now yours is so massive, but I think it’s kind of what you said is how it grew. If it grew towards your vocal cords or your laryngeal nerve or something, you would have had some pretty bad hoarseness or something like that. But it grew I guess backwards so it didn’t interfere that much. And I guess your s your body adapted gradually over time. You know, yes, it’s very possible for sure. Very common. Bill Gasiamis (16:49) And how would somebody interact with a general practitioner, for example, now to go through the process of understanding, A, their thyroid health and whether or not they have any nodules. Navigating Thyroid Health with Healthcare Providers Dr Hedaya (17:02) I mean in other words, given what we’ve talked about, how should they approach their doctor basically? Bill Gasiamis (17:07) Yeah. Dr Hedaya (17:08) I guess I would say go to AI, get a list of the symptoms of low thyroid or high thyroid or all of them, check them off. So then when you go to the doctor you have a list, check your temperature, check your pulse, although the doctor will should check that. And then you could say, look, I have these symptoms, or maybe you don’t have any. But if you do, you have these symptoms, and clearly thyroid hormone levels can affect the brain. And I’d like a TSH, a free T4, a free T3, and a reverse T3. That’s it. And if they Bill Gasiamis (17:45) Okay, perfect. Dr Hedaya (17:46) say, no, no, we don’t need to do that, you know, a lot of times what they do, they’ll just do a TSH. Or they won’t do the reverse T3. They don’t, unfortunately, look at the thyroid gland in a dynamic way. They say, the TSH is fine. If your thyroid was low, your TSH would go high. We don’t need to do the rest. But that’s not true. That’s not true at all. Because especially if you had a stroke, your pituitary function may be compromised. Your TSH may be fine or low and your low thyroid. As matter of fact, in the last interview, the case that I talked about, who referred me to you, she actually had a low TSH, but she had a very low, I think it was a free T4. Or free T3 or both, whatever it was, but she had too little thyroid hormone, and her pituitary couldn’t respond because of the stroke. Bill Gasiamis (18:37) understood. So that’s a great list of Dr Hedaya (18:37) So so be you have to be dogmatic and you say to the doctor, look Even put into even put into AI and say, look, if the doctor comes back to me and argues against these tests, what should I say? You gotta be prepared because the doctor will steamroll you. You know, that they only allow this, they only allow that, I’ll only do the free T4. Well, that doesn’t tell you how much has been converted to T3, free T3, and it doesn’t tell you, even if the free T3 is normal, that doesn’t mean you’re not overproducing thyroid and and dis you know, and neutralizing it with the reverse T three. So, you know I mean I I mean I think it’s s so important that a thorough look is is really important. If you have the symptoms, you know. Bill Gasiamis (19:22) I agree with you. That list of to-dos, I’m gonna put that on the show notes. People can go and get that list if they don’t wanna go into AI themselves or they haven’t got the time or whatever. They can just download it from there. And then they’ll be able to take that and begin a conversation with their general practitioner. What’s interesting is that I’m in Australia, you’re in the United States. My general practitioner is pushed back when a… when a patient will turn up and say, I have these tests? They’ll say, well, no, you don’t have any condition that is obvious that you need these tests. So it’s not covered. So you don’t need to do it. So my next suggestion to them is no problem. Order the tests and I’ll pay for them. Now it’s not ideal, but if you’re not going to do them for me and I need to know, cause it’s my health, I’m going to pay for them. So just tell me how much it is and I’ll find a way and I’ll make it happen and I’ll pay for it. So that’s another option. Dr Hedaya (20:17) Yeah. But if you go in with your symptom list, right, and you say, Well, that’s not true, because these are the symptoms, you know, that I have, here they are, right here. You can take a look, you know. And then the last thing I’ll say, this gets even more tricky, is the reference range, I’m sure in Australia, but certainly in the United States, the reference range basically is of the TSH, the pituitary home. Is 0.5 to 4.5, meaning you anywhere in that range and your TSH is normal. That is a bad reference range. And I know it to be a fact because I I I guess I won’t waste your time with it, but I did a study on a hundred people and with a very sensitive thyroid test called a TRH stimulation test. and I was able I hired a statistician to calculate this. And say, well, I don’t want to keep doing this test on everybody. What TSH predicts an abnormal TRH stimulation test? And he came back and said to me, Well, once the TSH is over 1.4, it starts to increase your odds of having an abnormal TRH stimulation. So I said, okay, so 1.4 TSH is my cutoff, right? That’s in my mind. I said, okay, that’s that’s my cutoff, that’s when I get suspicious. Later, several years later, a paper came out, a large, large study, called the NHANES Study, Nurses Health, and I’m not sure what it stands for. Thousands of people followed over many, many years, over decades, and they found the mean TSH in the US population is 1.4. So, right where I what right where my study found. So that means statistically, it is not. impossible to have the upper limit of the reference range being at four point five because statistically the upper limit is never more than two standard deviations. So even if your standard deviation is 1.4, which it can’t be, you you’re not going to reach 4.5, right? Unless you have a it’s called a bimodal distribution curve. If you have that, then you’d say, well, it it could be. But we don’t have that with thyroid. So that reference range is wrong. The upper limit of the reference range should be 2.5. And about half the endocrinologists in the United States believe that. And half say, no, no, no, don’t change it. So that’s another sticky point because, you know, easily people get a result and they’ll go to the doc and say, no, the reference range is 4.5. You’re normal. Then you could say, well, look, I have these symptoms, and they could do a literature search. What’s the normal reference point? What in in the N A N HANES N-H-A-N-E-S study? It’ll show you 1.4. and you could take be prepared to go to the doctor and say, Well, here’s a study that suggests that the reference range may be incorrect. and I have symptoms by the way. We don’t treat the lab, we treat the person. So could we give a trial? Just a trial, there’s no harm done, you know, trial. Let’s see let’s start at a very low dose. Let’s see how I feel. Maybe I’ll get better. I’ll come back in a month. Bill Gasiamis (23:45) Yeah, I love that. It’s really good advice, especially coming from someone who is a doctor who think is thinking on the same way as me, for example, the patient. Because that’s like a match made in heaven. And that’s so rare to be able to get that. Often, my challenge to my general practitioner was well, the reference range isn’t that average of a sick population, because it’s usually a sick population that comes to see you to get bloods. It’s It’s not the most healthiest people that come to see you to get bloods. And that’s kind of how I try to like start the conversation of convincing a general practitioner to do a test that they’re reluctant to do. And when I say they’re reluctant, I’m not in there every day. I’m not in there every week. And I’m not putting stress on the system to an extent where I’ve been over using the system. I’m not at all. in there once, twice a year, maybe, you so if I’m in once, twice a year, well, then, I’m not mucking around. Like I’ve come there to investigate something that I’m suspecting is wrong with me. It’s my body. I’m feeling something. had a bit of a look online. This is what I suspect. Don’t try and convince me out of my thinking or my instinct more better. Why don’t we just, work together to get to the bottom of it. If it is something it is, if it’s not, it’s not, and that’s okay. Not a big deal. I’m better to know. then not no, I think, you know, it’s better to be safe than sorry in my mind. Dr Hedaya (25:16) Yeah. I would I would only think only correction I would make is the reference ranges generally are made on normal populations. Now now the thing is who’s normal anymore? Number one. Number two, that’s a statistical norm that doesn’t tell you anything about your genetics. your vulnerabilities, it’s not an individualized statistic. I mean it’s it not an individualized thing. What’s your normal range? And are you out of your normal range? Nobody can answer that, right? Unless you had previous data before you were ill. And you say, well look, I’ve been running at a 1.1 for five years or 10 years and now I’m at 3.2. That’s a big change. Well, you know you’re stressed. Well yeah maybe but here are my symptoms. Always come back to your symptoms. Bill Gasiamis (26:11) Got it, got it. Dr Hedaya (26:12) No. Bill Gasiamis (26:13) You use the word stress just now and my general practitioner says, I might go in and some bloods might be out of whack or some things might be not feeling great. And he’ll say, are you stressed? And I’m like, well, I’m not stressed. like, I’m not stressed in any way that I can say is worse than normal. For example, I’m Dr Hedaya (26:35) Mm-hmm. Bill Gasiamis (26:36) just, you know, I’m attending to my clients at work. picking up the kids from school, I’m, you know, making sure the bills are paid. Like I’m just doing the normal things that I always Dr Hedaya (26:48) Right. Bill Gasiamis (26:48) do, which tend to be stressful. And somehow when we talk about stress, cortisol seems to come into the conversation. Dr Hedaya (26:57) Mm-hmm. The Role of Stress and Cortisol Bill Gasiamis (26:58) And I don’t know how to respond to a general practitioner who says to me, am I stressed? Because I’m not experiencing something extreme or dramatic. in the months before I came to see him. So can we have a conversation a little bit about stress, cortisol, what is stress, what is cortisol, are they linked? Tell me about that, give me your thoughts. Dr Hedaya (27:21) Okay. Okay, so this is a multi-layer system. Okay, it starts with your perception and your of a situation and the story you tell about you the story you tell yourself about the the situation and your need for control of a situation and as opposed to saying I’m in the flow of the universe and All right, this is you know, this is the way it is, and I’ll adapt to it. Not so easy by the way, but it’s a much healthier way because most things will not stress you. Now, pain, let’s say you stepped on a nail, you’re gonna have stress, okay? Totally stressful, etc. But there’s a a difference between pain and suffering. Most of our problem is suffering. Suffering is a result of thinking patterns. perspectives of yourself and the world and the future and blah blah blah. I could talk about that for a long time. And that is probably one of the most important places to intervene and to train yourself, etc. Now, once this thing is registered as stress, it goes through back to the hypothalamus and the pituitary where all those hormones are controlled, the hypothalamus and pituitary in the brain, now you’ve God forbid, you’ve had a stroke. Those things may be affected, therefore, those systems may not be working well. In that case, you may not be able to handle stresses that you used to handle. You may not you may not have those shock absorbers. So, how do you measure this? I think the way you measure it again are symptoms, and typically it would be low cortisol and low DHA, d DHEA, and low pregnenolone. And the symptoms would be a lot of fatigue, right? Maybe poor wound healing, muscle aches, body pains, getting sick more easily, cognitive slowing, depression, anxiety, extreme exhaustion, salt cravings, in unstable temperatures, you know, I would say yeah You know, th loss of appetite in severe cases, you know, dizziness on standing. Okay. So those are the low adrenal output things. Now how d how do you measure and again, you think you have a problem, go to an AI thing, make that list, check it off, whatever applies, and you know, work yourself up symptomatically and then ask well, okay, what what are the best tests here? What are the best test. Now the way I test it is I get morning I got a morning like eight to nine a.m fasting ACTH and cortisol. It’s gotta be in the morning around between eight and nine a.m. fasting. I also at the same time get a D, like David, H E A and a D H E A sulfate, and then I also get a pregnenolone. And if I think there’s any kind of sex hormone problem that I want to check, then I will check a free testosterone, FSH, LH, and The testosterone measures the free testosterone is very unreliable. So if it comes out low, you want to do it two more times to double check that. But the other measures are pretty reliable. And then you’ll you’ll know the other thing you can do is you could do something called a Dutch test, which is a urine test that’ll look at your cortisol through the day, or an adrenal saliva test. It’s ASI, alleval adrenal saliva index, the Dutch test. or the ASI, both good tests. and those will tell you what’s going on through the day. Like if you’re not sleeping, it could be because your cortisol high at night, you know. Wake up horrible or in pain. Could be because your cortisol is really low in the morning. Really low. You can’t even get out of bed, you know, can’t get going, right? So these are all all things that you can do to measure and then you can replace these hormones and That’s one thing to do. The other thing to do is to work on how you manage stress. There are millions of ways of doing that, right? From meditation to heart math to Bill Gasiamis (32:05) Mm-hmm. Dr Hedaya (32:06) yoga to you know, there’s just a lot a lot a lot of ways to Bill Gasiamis (32:10) Yeah, let’s go back for a moment and talk about testosterone because when I hear testosterone, I’m hearing you say to a male that I need to have testosterone in my body and at certain levels, et cetera. And sometimes it can fall out of whack and you need to get it tested. I had mine tested recently. It’s all good. But women also need testosterone. Tell me about that. Dr Hedaya (32:35) Yeah, so I was I was thinking of both male and female when I said it, Bill Gasiamis (32:38) Yeah. Dr Hedaya (32:39) because it’s it’s you know, women who are postmenopausal can have it’s much more common to have a low free testosterone loss of libido, you know. testosterone the studies which I’ve reviewed a few times, you know, there’s a debate does it affect the mind, the brain, you know. It seems to have an effect on well being, on vitality muscles, sex drive obviously, libido erectile function, brain cognitive function, some mood effects, etc. So I I think it’s important now i it it has to be managed in women as well as men. You know, in in women testosterone is a step on the way to estrogen as it is in men, right? And in the metabolism, right? So it it should certainly be assessed in everybody. Bill Gasiamis (33:39) Yeah. And estrogen, mentioned estrogen. Now, one of them in my mind, it seems to be more associated again to women, estrogen, especially. And, and then men also have estrogen, need estrogen. Dr Hedaya (33:55) Men also have estrogen. I haven’t studied it so I couldn’t tell you, but I imagine it’s doing something. it probably turns men into better leaders after they’re fifty, is my guess. Let Bill Gasiamis (34:08) more emotionally intelligent. Dr Hedaya (34:10) more emotionally intelligent, less testosterone, you know. You know, I I I Bill Gasiamis (34:15) You know what? That’s a good theory. We’ll run with that for now. I might relate to that, know, who knows. Dr Hedaya (34:22) Yeah. I I think Bill Gasiamis (34:24) Awesome, awesome, so… Dr Hedaya (34:24) Yeah, so w for for women on estrogen, it depends, you know, who are you assessing? Are you that’s a whole complex subject, you know. Is it a young woman who’s menstruating? Does she have premature ovarian failure, endometriosis, ovarian cysts, insulin resistance, they all kind of travel together, methylation problems, they travel together. is it someone who’s perimenopausal where she’s starting to lose progesterone and getting a lot of PMS? That’s pretty easy. You can replace the progesterone. Is it postmenopausal a woman who’s just kinda lost the estrogen, lost the progesterone? You know, if there’s a family history of cognitive decline or dementia or something like that, there’s great evidence that transdermal estrogen and some oral progesterone bio bioidentic, not synthetic, is great and reduces the risk for lots of disorders later in life for women. You know. So there’s a whole you know, there’s a whole way of working all that up, depending on who who you’re looking at. But very important. Now so the let me Bill Gasiamis (35:31) Yeah, I love it. Yeah. Dr Hedaya (35:34) say this. The important thing here, and this is maybe the most important thing. Someone’s had a stroke, they’re obviously tremendously stressed. You have to look at all the hormones. You can’t the brain is a hormonal organ. It’s an immune organ. It’s a neurological organ. I used to teach psycho, neuro, immuno, and the chronology at Georgetown for a number of years. Okay? And the brain and hormones, you can’t separate it. So if the brain is under stress, the hormonal axes are under stress, and there’s not one hormonal axis when it’s abnormal that cannot cause neurological or psychiatric problems. Okay? So you must, as part of the work of anyone who’s had stroke. You must look at the endocrine, the hormonal axis. You know, you must look at it. Why? Because if you’re trying to recover from a stroke and you don’t have adequate hormones, it’s gonna be much, much harder. Much, much harder. Right? But Bill Gasiamis (36:37) Peace. Dr Hedaya (36:38) if you have if you have the the hormones at good levels, okay, now the the brain has that. If it has its nutrients, it has that, you know, okay, now it can do something, you know. What happens, think about it this way. What happens in adolescence? The brain is being rewired, the body’s growing, brain is rew being rewired. Where are the hormones? The hormones are skyrocketing. They’re necessary for the rewiring. You had a stroke, you’re trying to rewire brain, you gotta have adequate hormones. Bill Gasiamis (37:10) I love it. This is the thing that people miss. You know, we talk about the gap in stroke recovery. Acute phase gets handled Dr Hedaya (37:19) That’s Bill Gasiamis (37:19) 99 % of the time really well. People get patched up and they get sent home in some kind of alive state, whether they are fully functional Dr Hedaya (37:27) Yeah. Bill Gasiamis (37:28) or working towards it or whether they are less functional and working towards being more functional, like some kind of stage Dr Hedaya (37:35) Mm-hmm. Bill Gasiamis (37:36) of you’re alive and you’re good enough to go home. And then there’s no information after that. So how do we assess address? How, what do we know? What do we not know that we need to know? And this is kind of what this conversation is, right? It’s like, okay, here’s Dr Hedaya (37:53) Yeah. Bill Gasiamis (37:53) a whole bunch of things we’ve just discussed. There might have been things that you heard for the first time. Don’t let that, get in the way of your curiosity and investigate the thing that pricked your ears up, whether it was a symptom that Dr. Hedaya mentioned and just do a little bit more work in understanding what that is, take that to your general practitioner and begin the conversation of taking responsibility for your recovery. And in my mind, like there’s gotta be like a foundational thing that people can do to intervene that doesn’t cost most of the time anything extra. And that helps encourage and nourish the brain in overcoming these challenges, but then has the a cascade effect of having the same positive outcome on all the other organs and hormones. And that to me is nutrition. So like, if you’re, if you would suggest to somebody how they might start thinking about their nutrition as opposed to what they might have been doing before stroke, how do you begin that conversation? And what are the two or three fundamental things that they need to consider? about nutrition. Nutrition’s Impact on Brain Recovery Dr Hedaya (39:11) Okay, so If it doesn’t grow that way, don’t eat it. I never saw a bread tree. I didn’t see an ice cream tree or a Twinkie tree. Okay. So if it doesn’t grow that way, don’t eat it. Balance your plate. Balance your plate. And actually our coach, Caroline Hade, is putting out an ebook. I don’t know, should be out at a week or two or three weeks. It’s like, I don’t know, four or five dollars or something. and that will tell you exactly how to balance your plate. and then I would say very important to have three meals and maybe, depending on your how insulin resistant you are, maybe additionally two snacks. and per day, but keep your calories you don’t want to be overweight, okay, because if you’re overweight, you know, that’s a That’s its own risk factor for brain problems, right? but you can’t lose weight in a day, you’re stressed, you’re hungry, you’re tired, you eat the carbs, you know, everybody struggles with that. But that that is one of the biggest enemies of eating eating eating these processed carbs that we all love is one of the biggest enemies of your health. One of the biggest enemies of your health for sure. Bill Gasiamis (40:35) Okay, there are some great resources that people can again look into how to eat to heal the brain. And we didn’t have to have a deep conversation about that. But I love Dr Hedaya (40:45) Mm-hmm. Bill Gasiamis (40:45) what you said about balancing the plate. And if it didn’t grow that way, don’t eat it. It’s such a simple thing. If it comes in a packet on a shelf in a supermarket with all fancy pictures Dr Hedaya (40:59) Yeah. Bill Gasiamis (41:00) and stickers and a list of ingredients, like it’s probably not nutritional. of food. It’s probably something that’s going to make inflammation worse. It’s probably something that’s going to give you the type of energy that is not helpful. It’s probably going to have a whole bunch of other things. And that’s kind of my approach to healing and recovering my brain. It’s one of the first things I did was just look at my nutrition, immediately stop smoking and drinking. mean, I know it should go without saying, but sometimes you have to have a stroke for it to actually sink in and make sense. and don’t have any alcohol at all. I’m talking about forever if you can, but I didn’t have alcohol Dr Hedaya (41:46) Yeah. Bill Gasiamis (41:47) for at least the first four or five years. And now in the next five years or so, maybe I had one glass per year, just because I was, in an event where it was, everyone was drinking and it was almost necessary to have sip or half a sip or act as if I was drinking. So with that, I think we’ll wrap up this conversation today. There’s been a lot for people to digest, go back and listen to it a second time. And a third time that we have some resources in the show notes. And Dr. Hedaya, thank you for joining me again. And I look forward to our conversation that’s coming up in a few weeks time where we’re going to talk about toxin load and neuroplasticity. Dr Hedaya (42:29) Beautiful. Thanks so much for the opportunity, Bill. I hope I hope people get something out of this and they pursue what they need to pursue. Bill Gasiamis (42:36) Well, that’s a wrap on this conversation with Dr. Robert Hedeya. If there’s one thing to take from today’s interview, it is this. The brain is a hormonal organ and recovery isn’t just about the brain healing in isolation. Thyroid, cortisol, testosterone, estrogen, all of it is connected, and all of it is worth checking if your recovery has plateaued in ways that don’t quite make sense. Dr. Hadea’s free PNIE questionnaire is linked in the show notes. Download it, work through it, and take it with you to your next GP visit. If you want to go deeper on the thyroid piece specifically, go back and listen to the earlier episode with Dr. Elena Zinkov on stroke fatigue and thyroid. And if you missed it, the first conversation with Dr. Hedeya on photobiomodulation is a great companion to this one. if this episode has helped you, share it with someone who needs to hear it. That’s genuinely the best way to help this show reach more survivors. My book, The Unexpected Way That a Stroke Became the Best Thing That Happened, is available at recoveryafterstroke.com/book. And if you’d like to support the show financially, you can do so at Patreon by going to patreon.com/recoveryafterstroke. Until next time, take care of yourself and don’t assume it’s just a stroke. The post Hormones, Fatigue, and the Brain: Dr. Robert Hedaya Returns appeared first on Recovery After Stroke.

Welcome back to Barn Talk! In this special episode, the conversation focused on uncovering the traits and habits that set successful people apart—especially those who've visited the barn as guests over the years. Instead of the usual hot topics, the discussion explored the common threads among high-achieving farmers, ranchers, entrepreneurs, and business owners, sharing lessons learned firsthand from memorable interviews and personal experiences. A key theme that emerged was the importance of going "all in," lifelong learning, resilience, humility, and staying true to your values of faith, family, and legacy. Tune in for an episode packed with insights and real stories aimed at inspiring anyone striving to carve their own path and live a life of meaning and purpose. JOIN THE BARN TALK NEWSLETTER & GET LIVE EVENT ACCESS: We're on a mission to get 10,000 subscribers, and once we do, we're hosting a live event at the barn! Sign up to get exclusive access to tickets and details.

When construction abruptly stopped at the former Pfizer headquarters redevelopment in Midtown Manhattan after workers discovered buckled steel columns and floor sagging, public attention quickly turned to one question: What happened? But before investigators can determine why a structural failure occurred, engineers must answer a different question: How do they stabilize a damaged building and safely determine what went wrong? In this special edition of the ENR Critical Path Podcast, host Bryan Gottlieb speaks with Christopher Raebel, vice president of engineering and research at the American Institute of Steel Construction, about the engineering response to structural emergencies. Rather than speculate about the ongoing investigation, Raebel explains how engineers assess structural damage, stabilize compromised buildings, investigate potential causes and determine whether damaged structures can be repaired. Whether you're an engineer, contractor or simply curious about how complex structural emergencies are managed, this conversation offers an inside look at the process that begins long before investigators reach their conclusions.

Johanna Danaher is a mindset, life and leadership coach who helps high-achieving pre-retirees and mid-life professionals navigate one of the most overlooked transitions of all: who you become after you leave a long-held career. After more than 25 years in high-level corporate leadership, guiding global talent, culture and leadership strategy at Pfizer, Johanna understands how deeply identity can become intertwined with a title—and how destabilizing it can feel when that chapter comes to an end. Through her coaching practice, Anchor to Aspire™, she now supports pre-retirees and midlife professionals as they navigate the emotional and psychological side of transition, helping them move forward with clarity, energy and intention. Johanna's work blends evidence-based tools with deeply human insight, drawing from Energy Leadership™, the Energy Leadership Index (ELI), Positive Intelligence®, Whole Brain Thinking and the science of happiness. She helps clients recognize how they show up on their best days versus under stress—and how small mindset and energy shifts can radically change their experience of retirement, reinvention and life transitions.What sets Johanna apart is her ability to honor paradox: ambition and ease, resilience and softness, structure and surrender. Her clients—executives, public-sector leaders and long-tenured professionals—aren't looking to stop growing; they want their next chapter to feel meaningful rather than performative, intentional rather than fear-driven.A former marine biologist turned HR leader and now entrepreneur, Johanna's nonlinear path shapes a coaching approach rooted in possibility. Whether she's guiding a team through reinvention or helping someone redefine what success means in midlife, her work is both strategic and soulful—anchoring people to who they are so they can rise into what's next.Some topics we cover in this episode:--How to prepare emotionally for retirement--How to maintain identity after retirement by determining what you value--Why do so many people rush to stay busy after retirement and the cost of doing so--How pre-retirees can learn to shift and reframe fear and uncertainty about their identity or their future—and use it as fuel for an intentional and empowered "rewirement"--How pausing can be a superpowerLearn more:Website: https://anchortoaspire.com/ LinkedIn: https://www.linkedin.com/in/johannadanaher/ IG: https://www.instagram.com/anchortoaspire/Facebook: https://www.facebook.com/anchortoaspire/Blog: https://anchortoaspire.com/blog-posts

Please see https://www.pfi.sr/HYMPAVZI_PI for Full PI On this episode of BloodStream, Patrick facilitates a conversation between Peter, who is living with hemophilia A, and Dr. Tammuella Chrisentery-Singleton, a board-certified hematologist and Chief Science Officer (CSO) for The American Thrombosis and Hemostasis Network (ATHN), to explore the shared decision-making process and why it matters. We'll provide listeners with the latest on HYMPAVZI (marstacimab-hncq) and highlight the value of shared decision-making. HYMPAVZI may cause serious side effects, including blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. To learn more about this risk and additional safety information visit HYMPAVZI.com. This post is directed to a U.S. audience and may not be suitable outside of the U.S. This video is intended to be viewed as it was originally produced in partnership with Pfizer. Remember, this content is for educational purposes only and does not replace discussions with a healthcare provider. PP-HYM-USA-1115 Show Notes: For safety information visit: https://labeling.pfizer.com/ShowLabeling.aspx?id=20916&Section=PPI For information on how to navigate your treatment journey, visit the Shared Decision-making Guide here. Listen and subscribe where you get your podcasts! #Hemophilia IMPORTANT SAFETY INFORMATION Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products or "bypassing agents" (products that help blood clot but work in a different way than HYMPAVZI). Your healthcare provider may prescribe factor VIII or factor IX medicines or bypassing agents to treat episodes of breakthrough bleeding during your treatment with HYMPAVZI. Carefully follow your healthcare provider's instructions regarding when to use these medicines and the prescribed dose during your treatment with HYMPAVZI. Do not use additional doses of HYMPAVZI to treat breakthrough bleeds. Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you: have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery. have a severe short-term (acute) illness such as an infection or injury. have been told that you have a risk for blood clots. are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby. Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI. Use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI. are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. If you inject too much HYMPAVZI, call your healthcare provider or the Poison Help Line at 1-800-222-1222 or go to the nearest hospital emergency room right away. What are the possible side effects of HYMPAVZI? HYMPAVZI may cause serious side effects, including: blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. Blood clots have happened in people using HYMPAVZI. You may have an increased risk of blood clots if you have certain risk factors. Stop using HYMPAVZI and get medical help right away if you develop any of these signs or symptoms of blood clots: swelling or pain in your arms or legs redness or discoloration in your arms or legs shortness of breath pain in chest or upper back fast heart rate cough up blood feeling faint headache numbness in your face eye pain or swelling trouble seeing allergic reactions. HYMPAVZI may cause allergic reactions, including rash and itching. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction: swelling of your face, lips, mouth, or tongue trouble breathing wheezing dizziness or fainting  fast heartbeat or pounding in your chest  sweating The most common side effects of HYMPAVZI include: swelling, hardening, redness, bruising, bleeding, and pain at injection site headache fever joint pain  diarrhea  itching  rash  These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. What is HYMPAVZI? HYMPAVZI is a prescription medicine used regularly to prevent or reduce the frequency of bleeding episodes in adults and children 6 years of age and older with: hemophilia A with or without factor VIII inhibitors, or hemophilia B with or without factor IX inhibitors. It is not known if HYMPAVZI is safe and effective in people receiving ongoing Immune Tolerance Induction (ITI).  It is not known if HYMPAVZI is safe and effective in children younger than 6 years of age.

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. The industry continues to forge ahead, making significant strides in scientific advancements, regulatory approvals, and strategic business developments. These moves are reshaping the landscape of drug development and patient care. Starting with Merck & Co.'s recent FDA approval for Lipfendra, the world's first oral PCSK9 inhibitor, this marks a pivotal shift in managing hypercholesterolemia. Traditionally, PCSK9 inhibitors have been administered via injection, but Lipfendra offers a more convenient oral alternative. This could significantly improve patient adherence and outcomes by easing the administration process for those managing cholesterol levels. The drug's approval highlights a crucial advancement in cardiovascular treatment, with expectations of reaching peak annual sales of $5 billion, underscoring its market potential. In another significant development, Eli Lilly has entered the burgeoning field of psychedelic therapeutics with its acquisition of Ataibeckley for up to $3.8 billion. This move reflects a growing trend toward exploring novel therapeutic avenues for psychiatric disorders. Psychedelic compounds promise new hope for patients with depression and other mental health conditions where conventional therapies have shown limited efficacy. Eli Lilly's investment signals confidence in the transformative potential of psychedelics, which could revolutionize treatment paradigms for conditions like depression and PTSD. Turning to obesity treatment, Novo Nordisk's Wegovy pill has received European Commission approval for obesity and overweight adults. As a small molecule GLP-1 receptor agonist, semaglutide enhances satiety and reduces caloric intake. This development underscores the increasing focus on metabolic disorders and highlights the competitive landscape as companies race to dominate the weight management sector with innovative oral formulations. In oncology news, Merck & Co.'s Keytruda has achieved a milestone in becoming the first PD-1 inhibitor to demonstrate phase 3 benefits as a single agent in frontline mismatch repair-deficient endometrial cancer. This success not only reinforces Keytruda's role in oncology but also emphasizes the importance of precision medicine approaches targeting specific genetic mutations in cancer therapy. The industry is also seeing substantial financial maneuvers aimed at bolstering research capabilities and market reach. Johnson & Johnson has raised its 2026 financial guidance following Tremfya's impressive $2 billion revenue milestone with its IL-23 inhibitor for autoimmune diseases. Additionally, their strategic supply chain restructuring reflects efforts to enhance operational efficiency amid a broader U.S. manufacturing push. On the regulatory front, Johnson & Johnson received UK MHRA approval for Akeega in BRCA1/2-mutated metastatic prostate cancer, highlighting ongoing focus on precision medicine and targeted therapies in oncology. Meanwhile, Medtronic's recall of Harmony Catheter Delivery Systems due to safety concerns serves as a reminder of ongoing vigilance in medical device safety regulations. In clinical trial advancements, InnoCare Pharma's TYK2 inhibitor demonstrated efficacy in a Phase 2 trial for nonsegmental vitiligo, achieving its primary endpoint and paving the way for Phase 3 studies. This highlights TYK2 inhibition as a promising strategy for autoimmune diseases like vitiligo. Moreover, we witness movements towards public offerings with companies like Vogenx and Braveheart Bio aiming for IPOs to fund their respective drug development projects. These efforts underscore the continuous drive for capital to propel innovative therapies through clinical trials and towards commercialization. Finally, turning to regulatory updates, Sanofi has entered new chapters in mRNA patent litigation against Pfizer and Moderna, reflecting ongoing tensions over intellectual property rights within the high-stakes realm of COVID-19 vaccines and mRNA technology. The outcomes here could have far-reaching implications for mRNA-based therapeutics and vaccine development. As we look at these developments collectively, they illustrate a vibrant period for pharmaceutical and biotech companies innovating new treatments while navigating complex regulatory terrains. The implications for patient care are profound, with potential improvements in therapeutic options driven by new scientific breakthroughs and strategic industry shifts. These dynamics promise to reshape the future landscape of global healthcare delivery and pharmaceutical innovation as these trends continue to unfold.Support the show

A construction worker named Sean Dow was working on the 22nd floor of Pfizer's former Manhattan headquarters, a massive office building now being converted into residential apartments with additional floors being added.Dow noticed cracks in a concrete slab. When he investigated further, he found a structural column visibly bending. But when he raised the concern, the initial response from the general contractor was reportedly, “Don't worry, you'll work on the floor below.”Dow kept pushing. Workers were evacuated, and investigators later found floors sagging by as much as four inches.The story illustrates an important distinction in psychological safety. People remain silent not only because they fear punishment, but also because they believe speaking up will accomplish nothing.A genuine speak-up culture requires concerns to feel both safe to raise and worthwhile to raise. The real test is not whether leaders say they welcome concerns. It is what they do in the first minute after someone brings one forward.Do they dismiss the concern and offer reassurance without investigating? Or do they respond with curiosity and say, “Show me”?An organization that depends on unusually persistent workers to overcome a dismissive first response is not operating a strong safety culture. It is operating on luck.

"I always remember feeling like I was part of the clean plate club," says Dr. Christle Guevarra, recalling a childhood spent quietly convinced that her weight was a matter of willpower. That belief followed her through a competitive powerlifting career and medical practice until she finally tried a GLP-1 medication herself and, as she describes it, the constant mental noise around food quieted down. Now a board-certified family and sports medicine physician, traveling team doctor for U.S. Figure Skating, and author of The Beginner's Guide to GLP-1s, Dr. Guevarra brings a rare combination of clinical authority and lived experience to the conversation around obesity medicine.  In this episode of Raise the Line from Elsevier, host Lindsey Smith talks with her about what's actually changed in how physicians understand the issue and what it means for patients. "The biggest thing is reframing how we approach weight loss. It's not just a willpower problem, it is a neurobiological problem." Tune in to learn about: Why she said no to a GLP-1 prescription for two years and what finally changed her mind; The real story behind concerns about muscle loss on these medications; What happens when the “food noise" goes silent and a new set of challenges takes its place.   Mentioned in this episode:  Dr. Christle's website If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

AUA2026: Focus on: ADT in the Modern Era - Balancing Cancer Control and Cardiovascular Safety CME Available: https://cme.auanet.org/URL/FOCUS265ONL LEARNING OBJECTIVES: After participating in this CME activity, participants will be able to: 1. Integrate cardiovascular (CV) risk assessment into ADT initiation by applying key findings from the REVELUTION-1 trial to identify patients at elevated risk for atherosclerosis and MACE. 2. Compare and apply the CV safety profiles of LHRH agonists versus GnRH receptor antagonists to guide personalized ADT selection in patients with varying CV risk. 3. Implement streamlined monitoring strategies for men on oral ADT, including testosterone levels, lipid and blood pressure evaluation, and surveillance for early CV risk indicators. 4. Collaborate with cardiology and primary care to optimize statin use and coordinate CV risk-reduction strategies for prostate cancer patients receiving ADT. 5. Strengthen shared decision making and adherence by incorporating discussions of oncologic benefit, CV risk, and mitigation strategies into routine oral ADT counseling and follow-up. ACKNOWLEDGEMENTS: Support provided by independent educational grants from: Pfizer, Inc Sumitomo Pharma America, Inc.

Today's podcast continues our discussion of the structural failure at the former Pfizer headquarters in Midtown Manhattan, where a massive office-to-residential conversion suffered localized structural distress during construction.The investigation has only begun. Engineers have not yet reached any conclusions about the root cause, and it would be inappropriate to speculate. The building may ultimately be repaired, strengthened, and safely completed. Or investigators may determine that more extensive reconstruction is required. We simply don't know.But even before the engineering investigation is complete, another consequence has already begun to unfold.Reputation.Real estate is built on confidence. Lenders finance confidence. Investors buy confidence. Insurance companies price confidence. Residents lease confidence.When confidence disappears, value disappears.We saw this after the collapse of Champlain Towers South in Surfside, Florida. The tragedy permanently changed how buyers viewed aging condominium buildings. Reserve studies became front-page news. Deferred maintenance became a deal breaker. Insurance premiums exploded. Financing became more difficult. Thousands of condominium owners across Florida found themselves facing six-figure special assessments simply because the market had fundamentally re-priced structural risk.Whether fair or not, that event changed public perception.------------**Real Estate Espresso Podcast:** Spotify: [The Real Estate Espresso Podcast](https://open.spotify.com/show/3GvtwRmTq4r3es8cbw8jW0?si=c75ea506a6694ef1)   iTunes: [The Real Estate Espresso Podcast](https://podcasts.apple.com/ca/podcast/the-real-estate-espresso-podcast/id1340482613)   Website: [www.victorjm.com](http://www.victorjm.com)   LinkedIn: [Victor Menasce](http://www.linkedin.com/in/vmenasce)   YouTube: [The Real Estate Espresso Podcast](http://www.youtube.com/@victorjmenasce6734)   Facebook: [www.facebook.com/realestateespresso](http://www.facebook.com/realestateespresso)   Email: [podcast@victorjm.com](mailto:podcast@victorjm.com)  **Y Street Capital:** Website: [www.ystreetcapital.com](http://www.ystreetcapital.com)   Facebook: [www.facebook.com/YStreetCapital](https://www.facebook.com/YStreetCapital)   Instagram: [@ystreetcapital](http://www.instagram.com/ystreetcapital)  

In this episode of The Wrap with Chris Whalen, Chris expects the Federal Reserve will deliver one rate hike before Labor Day despite Warsh's preference to delay—the White House has greenlit it to maintain Warsh's credibility as chairman, and this one hike will likely lead to more because incremental Fed policy changes don't stop at one when fighting inflation. The Iran ceasefire has shattered and won't be fixed: Iran has zero incentive to reach peace with the U.S., wants to tax Strait of Hormuz traffic, and will force Gulf states to build pipelines and avoid the strait entirely—oil refineries won't be rebuilt while shooting continues, causing permanent structural supply damage. U.S. oil stocks are at their lowest level in 20 years, diesel is up 30% this year and ripples through every part of the economy, and California is facing potential rationing after it runs down reserves and stops getting refined products from Asia. Whalen stands firm on his double-digit inflation call despite prediction markets showing lower odds, arguing the real economy—not market probabilities—determines consumer and producer behavior, and rising consumer inflation expectations (3.7% one-year) are changing psychology and forcing real estate hedging. Bank earnings next week will reveal whether credit costs continue rising as spreads widen between Treasuries and corporate bonds, signaling medium-term economic slowdown ahead as speculative companies lose financing access.Thank you to our sponsor, Monetary Metals. Learn more at https://www.monetary-metals.com/THEWRAP/Links:    The Institutional Risk Analyst: https://www.theinstitutionalriskanalyst.com/  The Wrap: https://www.theinstitutionalriskanalyst.com/post/theira866Twitter/X: https://twitter.com/rcwhalen    The Entropy Trap: https://www.amazon.com/Entropy-Trap-Physics-Knows-Markets/dp/B0H1ZP7NZX/ref=sr_1_1Use the code TheWrap2026 for 25% off your first year of The Institutional Risk Analyst https://www.theinstitutionalriskanalyst.com/plans-pricingTimestamps:0:00 Warsh slow walking rate cut, White House greenlit one hike1:32 FOMC divided, one rate hike likely before Labor Day2:35 White House supporting Warsh to maintain credibility3:39 One hike doesn't typically happen alone4:42 Warsh reducing Fed presence, pulling back on forward guidance5:10 Fed's 2% target won't change consumer behavior on inflation7:29 Oil stocks at 20-year low, diesel shortage critical11:40 Iran ceasefire fragile, no incentive for lasting peace13:41 U.S. must build pipelines, avoid Strait of Hormuz14:08 Physical oil stocks depleted, refined products in short supply15:26 Diesel is political issue - impacts economy, employment16:06 California facing potential rationing without supplies16:36 Diesel up 30% this year, ripples through entire economy17:32 Double-digit inflation thesis still stands despite market skeptics18:46 Prediction markets vs real economy - spreads tell story20:06 Consumer inflation expectations hit 3.7% one-year (3-year high)20:27 Psychology of inflation changes spending and investment behavior21:34 Real estate traditional hedge, prices skyrocketing22:20 Spreads widening, economy slowing medium-term23:35 Earnings season next week - credit costs key indicator24:19 Midterms - Democrats take House, Trump faces impeachment25:32 Politics won't change, nothing gets done26:41 Pfizer building conversion collapsing, structural problems29:17 Bunker Hill Mining penny stock opportunity, silver revival31:28 Banks earnings - watch credit costs, mortgage issuers follow

The structural failure on 42nd St. in Midtown Manhattan this past week made headlines all over the world. The building in question was originally an office building belonging to Pfizer and is now in the process of being converted into a residential apartment building. It is the largest office to residential conversion project in US history and will result in nearly 1600 apartments.The structural design of a building is based on several factors. The first is, of course, the weight of all of the levels of the building that are being supported above the current level. The second is the lateral forces that result from the wind, pushing the building sideways.These are usually handled with sheer walls or diagonal bracing members that prevent the building from deflecting sideways.This is where most structural engineers get it wrong. The assumption is that if the wind is blowing from one side of the building, you have a zone of high-pressure on that side in a zone of low pressure on the opposite side. intuitively this makes sense. Wind tends to flow in a straight line. But in a dense urban environment with lots of surrounding buildings, the wind can and often does go in circles as it makes its way around the neighbouring buildings. In fact, there are many examples of structural failures in New York City, where the wind can often cause a building to twist like a corkscrew rather than just trying to bend to the wind. When that happens, the structural columns in the corners are the ones that experience the most stress. They're almost always the ones that fail first. I'm going to bet that wind was a contributing factor. Now if you look at the weather on the day of the failure, the wind was light ranging from 5-7 mph out of the north west. Hardly the conditions that would damage a building. The heat an humidity on July 3 triggered powerful afternoon and evening thunderstorms across the city, bringing damaging wind gusts that caused localized power outages for over 17,000 New Yorkers before conditions calmed back down. I suspect that the damage happened on July 3 and was not noticed until Tuesday when the columns progressively moved and buckled. ------------**Real Estate Espresso Podcast:** Spotify: [The Real Estate Espresso Podcast](https://open.spotify.com/show/3GvtwRmTq4r3es8cbw8jW0?si=c75ea506a6694ef1)   iTunes: [The Real Estate Espresso Podcast](https://podcasts.apple.com/ca/podcast/the-real-estate-espresso-podcast/id1340482613)   Website: [www.victorjm.com](http://www.victorjm.com)   LinkedIn: [Victor Menasce](http://www.linkedin.com/in/vmenasce)   YouTube: [The Real Estate Espresso Podcast](http://www.youtube.com/@victorjmenasce6734)   Facebook: [www.facebook.com/realestateespresso](http://www.facebook.com/realestateespresso)   Email: [podcast@victorjm.com](mailto:podcast@victorjm.com)  **Y Street Capital:** Website: [www.ystreetcapital.com](http://www.ystreetcapital.com)   Facebook: [www.facebook.com/YStreetCapital](https://www.facebook.com/YStreetCapital)   Instagram: [@ystreetcapital](http://www.instagram.com/ystreetcapital)  

On Tuesday morning, something potentially very scary happened in New York City. Images of buckling steel beams at the former Pfizer headquarters led to a large evacuation in midtown Manhattan. WSJ's Peter Grant reports on what happened and what this high-profile setback means for the nationwide trend of converting empty skyscrapers into apartments. Ryan Knutson hosts. Further Listening: - Compass vs. Zillow: The Real Estate Wars - Who's in Charge of Fixing Miami's Aging Condos? Sign up for WSJ's free What's News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Post-COVID, New York state and city officials have enacted a range of measures and tax breaks to speed up the conversion of old office buildings into new apartment complexes. David Brand, housing reporter for WNYC and Gothamist discusses the latest, including an extreme structural failure that recently happened at Pfizer's former headquarters in Midtown. Plus, Peter Varsalona, principal and building design group team leader at RAND Engineering & Architecture, talks about office-to-residential conversions, additions to existing buildings and the engineering considerations involved.   Photo: Mayor Zohran Kwame Mamdani briefs the media with NYC Department of Buildings (DOB), New York City Fire Department (FDNY) and New York City Emergency Management Department (NYCEM) officials on a Structurally Compromised Midtown Building on Tuesday, July 7, 2026. Michael Appleton/Mayoral Photography Office Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Palm Beach International Airport has been renamed Donald J. Trump International Airport. Some travelers may choose other airports due to the new name. The U.S. continues airstrikes on Iran. Ukraine's President Zelensky is making progress in the war with Russia. Mark reports on infrastructure problems at the old Pfizer building on 42nd Street in Manhattan.See omnystudio.com/listener for privacy information.

Palm Beach International Airport has been renamed Donald J. Trump International Airport. Some travelers may choose other airports due to the new name. The U.S. continues airstrikes on Iran. Ukraine's President Zelensky is making progress in the war with Russia. Mark reports on infrastructure problems at the old Pfizer building on 42nd Street in Manhattan. Mark interviews economist Steve Moore. Steve warns that the conflict with Iran could raise energy prices and worsen inflation. He also gives his opinion on Graham Plattner dropping out of the Maine political race. Mark and Steve discuss Governor Kathy Hochul's idea to regulate home temperatures in New York, and whether Bruce Blakeman could lead a turnaround in New York City if he wins the gubernatorial race over the next 6 months.  Graham Plattner has ended his campaign in Maine after heavy criticism from Democrats and others. Mark plays clips of Plattner's speeches. Is binge-watching TV becoming less popular? Mark interviews WOR weeknight host Jimmy Failla. Jimmy criticizes Mayor Zohran Mamdani for changing immigration neighborhood maps, affecting Little Italy. Mark and Jimmy also talk about Plattner's public image, and Jimmy gives a humorous take on FIFA World Cup soccer in the U.S.See omnystudio.com/listener for privacy information.

Palm Beach International Airport has been renamed Donald J. Trump International Airport. Some travelers may choose other airports due to the new name. The U.S. continues airstrikes on Iran. Ukraine's President Zelensky is making progress in the war with Russia. Mark reports on infrastructure problems at the old Pfizer building on 42nd Street in Manhattan. Mark takes your calls!  Mark interviews economist Steve Moore. Steve warns that the conflict with Iran could raise energy prices and worsen inflation. He also gives his opinion on Graham Plattner dropping out of the Maine political race. Mark and Steve discuss Governor Kathy Hochul's idea to regulate home temperatures in New York, and whether Bruce Blakeman could lead a turnaround in New York City if he wins the gubernatorial race over the next 6 months. See omnystudio.com/listener for privacy information.

July 9, 2026#WhatILearnedTodayDownload The Daily MoJo APP for Android HEREDownload TDM App For IOS: HERE"No Ceasefire For You! | The Daily MoJo Ep:070926"This episode of The Daily Mojo, hosted by Brad Staggs and Ron Phillips, features Brandon Morse discussing significant global events. Topics include US military actions in Iran, NATO defense spending, and international relations. The podcast also delves into societal issues, technological advancements like smart glasses, and controversial legal cases, offering a comprehensive overview of current affairs.Phil Bell's Morning Update Another way for the government to control your movements:  HEREBrandon Morse - Redstate Author & host of The Brandon Morse YouTube channel-  Has some thoughts about Hollywood's downfall and why it's so well-deserved. Brandon's latest video: HEREBrandon's LinktreeOur affiliate partners:Be prepared! Not scared. Need some Ivermection? Some Hydroxychloroquine? Don't have a doctor who fancies your crazy ideas? We have good news - Dr. Stella Immanuel has teamed up with The Daily MoJo to keep you healthy and happy all year long! Not only can she provide you with those necessary prophylactics, but StellasMoJo.com has plenty of other things to keep you and your body in tip-top shape. Use Promo Code: DailyMoJo to save $$Take care of your body - it's the only one you'll get and it's your temple! We've partnered with Sugar Creek Goods to help you care for yourself in an all-natural way. And in this case, "all natural" doesn't mean it doesn't work! Save 15% on your order with promo code "DailyMojo" at SmellMyMoJo.comCBD is almost everywhere you look these days, so the answer isn't so much where can you get it, it's more about - where can you get the CBD products that actually work!? Certainly, NOT at the gas station! Patriots Relief says it all in the name, and you can save an incredible 40% with the promo code "DailyMojo" at GetMoJoCBD.com!Romika Designs is an awesome American small business that specializes in creating laser-engraved gifts and awards for you, your family, and your employees. Want something special for someone special? Find exactly what you want at MoJoLaserPros.com  Find great deals on American-made products at MoJoMyPillow.com. Mike Lindell – a true patriot in our eyes – puts his money where his mouth (and products) is/are. Find tremendous deals at MoJoMyPillow.com – Promo Code: MoJo50  Life gets messy – sometimes really messy. Be ready for the next mess with survival food and tools from My Patriot Supply. A 25 year shelf life and fantastic variety are just the beginning of the long list of reasons to get your emergency rations at PrepareWithMoJo50.comStay ConnectedWATCH The Daily Mojo LIVE 7-9a CT: www.TheDailyMojo.com Rumble: HEREOr just LISTEN:The Daily MoJo ChannelBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-daily-mojo-with-brad-staggs--3085897/support.WATCH: TheDailyMoJO.comLISTEN: TDM RadioRUMBLE: HEREDownload the APP HERE.StellasMojo.comCODE: dailymojo - Save 5%GetMojoCBD.comCODE: dailymojo - Save 40%!

Christian Boucousis (@christianbooboucousis) was the youngest ever Royal Australian Air Force Pilot, earning the call sign "Boo" which has become his personal brand. His business Afterburner brings together a high-performing team of fighter pilots to teach businesses how they can leverage the power of the fighter pilot mindset. They've transformed performance at 3,500+ companies like Google, Pfizer, Microsoft, Apple, Nike, American Express, IBM, & Marriott, just to name a few. They've worked with 17 NFL teams, helping two win Super Bowls, including the record-breaking Super Bowl XLVI, when the New York Giants became the first team in history to reach the Super Bowl with a negative point differential (394 scored vs. 400 against). Boo has been featured on national outlets like The Today Show, New York Times, & Fox Business, and is the author of The Afterburner Advantage and upcoming Flawless Leadership. In our conversation today, we discuss how the fighter pilot mindset allows you to communicate better and how the key to leadership is doing what's right, not worrying about who is right.  Connect: https://callmeboo.com/ https://www.linkedin.com/in/christian-boo-boucousis/ CAPTAIN: THE ATHLETE'S GUIDE TO BEING AN EXCEPTIONAL TEAM LEADER is now live on Amazon!  CLICK HERE TO ORDER We are constantly asked "where have all the leaders gone?" Now more than ever, it is up to schools, clubs and coaches to develop our leaders, and this new book is a perfect guide to train and develop them. It is filled with stories of champion team captains on the professional and college level, Hall of Fame coaches, and more, and is a masterclass on leadership. Your athletes will learn from leaders such as Carles Puyol Abby Wambach, Tim Duncan, Shane Battier, Richie McCaw, Carla Overbeck and Simone Biles. It will help your athletes understand the qualities needed to lead, the responsibilities they must accept, and the most common challenges they will face. The chapters are short and sweet and have discussion questions so that your leaders can work through them together and set your team up for great success. The book also comes with a  FREE downloadable 10-session curriculum so you can guide your team or the leaders in your school or club through the entire book.  FOR ORDERS OF 10 OR MORE, WE OFFER A $5 PER BOOK DISCOUNT. EMAIL John@ChangingTheGameProject.com to place your order. BOOK A SPEAKER: Interested in having John or one of our speaking team present to your school, club or coaching event, either in person or virtually? Looking for leadership training for your student athletes, a coach development workshop or parent education? We are still booking Fall 2026 events, please email us to set up an introductory call John@ChangingTheGameProject.com PUT IN YOUR BULK BOOK ORDERS FOR OUR BESTSELLING BOOKS, AND JOIN 2026 CHAMPIONSHIP TEAMS FROM SYRACUSE MENS LAX, UNC AND NAVY WOMENS LAX, AND MORE! These are just the most recent championship teams using THE CHAMPION TEAMMATE book with their athletes and support teams. Many of these coaches are also getting THE CHAMPION SPORTS PARENT so their team parents can be part of a successful culture. Schools and clubs are using EVERY MOMENT MATTERS for staff development and book clubs. Are you?  We have been fulfilling numerous bulk orders for some of the top high school and collegiate sports programs in the country, will your team be next? Click here to visit John's author page on Amazon Click here to visit Jerry's author page on Amazon Please email John@ChangingTheGameProject.com if you want discounted pricing on 10 or more books on any of our books. Thanks everyone. This week's podcast is brought to you by our friends at Sprocket Sports.  Sprocket Sports is a software platform for youth sports clubs.  Yeah, there are a lot of these systems out there, but Sprocket provides the full enchilada. They give you all the cool front-end stuff to make your club look good– like websites, communication tools and marketing tools – AND all the back-end transactions and services to run your business better so you can focus on what really matters – your players and your teams. Sprocket is built for those clubs looking to thrive, not just survive, in the competitive world of youth sports clubs.  So if you've been looking for a true business partner – not just another app – check them out today at https://sprocketsports.me/CTG.

//The Wire//2300Z July 9, 2026// //ROUTINE// //BLUF: WAR CONTINUES IN MIDDLE EAST AS CEASEFIRE REMAINS DEFUNCT FOR NOW. MERCHANT TRAFFIC IN HORMUZ SLOWS TO A CRAWL DUE TO TARGETING.// -----BEGIN TEARLINE------International Events-Middle East: The war continued to escalate overnight, with many targeting efforts being undertaken by the United States and Iran. Within Iran, the U.S. continued to strike coastal sites and fastboat ports, in addition to striking more substantial infrastructure targets deep within Iran. These strikes continued throughout the day, with explosions being reported around the country this afternoon.On the Iranian side, many strikes were carried out on the usual sites throughout the region. In Kuwait, Ali Al Salem Airbase and Camp Arifjan were targeted, with the Iranians claiming to hit a Patriot battery at one of these sites. In Qatar, a radar installation was targeted, and a fuel depot was targeted in Bahrain. In Jordan, Muwaffaq Salti Air Base was targeted again, with the American Embassy in Amman urging all Americans to shelter in place during the strikes. Drone/missile strikes were also reported targeting U.S. positions in Erbil, Iraq, the success of which is currently unknown.-HomeFront-New York: The Department of Buildings has reported that the former Pfizer building has largely been stabilized, after severe buckling and a partial collapse of the upper floors was observed a few days ago. Various reinforcement operations continue to be undertaken to further stabilize the structure, and a third-party construction firm has been brought in to conduct additional repairs.-----END TEARLINE-----Analyst Comments: Despite many airframes being transferred back to the United States from the Middle East, American targeting within Iran has continued throughout the day. The heavy reliance on Tomahawk munitions (as observed on the ground by Iranians) also adds weight to the theory of the US having to rely on standoff munitions due to the logistical movements resulting in fewer aircraft being available for bombing runs.Also, last night's strikes were also possibly more significant than meets the eye. Locals on the ground reported the Aq Taqeh Khan railway bridge being struck overnight, which was interesting due to it's location being in the far northeastern corner of Iran. This bridge is part of the newly unveiled China-Iran railway network, which is a series of rail lines linking Iran to western China. These lines also meander through the mountains to eventually connect to Russia via Turkmenistan and Kazakhstan. Taking out this bridge was not only interesting because it is one of the farthest-north targets struck during the entire war, but it's also a very public message to China, who has been long-suspected of shipping the Iranians materiel and supplies to carry on the fight. In the Strait of Hormuz, civilian merchant traffic continued to transit the waterway, but since last night the traffic has slowed to a halt again with very few crossings throughout the day. As a reminder, it takes up to two months for a tanker to make it's way to the US from the Middle East. Consequently, if the Iranians shut down the Strait again due to this targeting (or if companies simply decide that the risk isn't worth it), the world will only have the benefit of a handful of tankers which have been able to make the crossing over the past couple of weeks. This does not even remotely come close to alleviating the problems that prompted the MOU being signed...President Trump himself said that (at the time) the US only had about 4 weeks worth of Strategic Reserve left before shortages began. As the fighting has resumed to some degree, the status of the global energy crisis remains a very real concern, and the clock starts ticking down as the flow of petroleum slows down once again.Analyst: S2A1 Research: https://publish.obsidian.md/s2underground NomadNet: 5fa68c88be727a0e1a250a75e5e79269 Disclaimer: No LLMs were used in the writing of this report. //END REPORT//

Rob breaks down Trump's full 720 back to war with Iran, the Taylor Swift wedding money-laundering theory, a cracked support beam in the old Pfizer building, and a sales-tactics analysis of why Trump's closing moves are finally failing him. Plus Patriot missiles to Ukraine, a Tyler Robinson trial check-in, and the sketchy US-Israel military arrangement.Shorter mid-week drop. See Rob in Galveston Sunday — full dates at RobBernsteinComedy.comSponsor: Sheath Underwear — code RYM for 20% off.Bonus content on RobBernstein.com — $5/mo.

Millions of Americans were saddened and outraged by the Sandy Hook Elementary shooting in 2012 that took the lives of twenty children and six adults, and were left feeling helpless about the epidemic of gun violence in the U.S. that, sadly, continues to this day. But for our guest today, Shannon Watts, her feelings of devastation about the shooting turned to rage and fueled her unlikely rise to leading Moms Demand Action, which she grew into one of the largest grassroots organizations in the country, mobilizing millions of volunteers to push for stronger gun safety laws. “I wanted to stand shoulder to shoulder with a badass army of women because that's who gets things done in this country,” she says.    In this inspiring conversation with Raise the Line host Michael Carrese, Watts pulls back the curtain on how the group achieved its successes and the philosophy of "losing forward" that kept volunteers showing up year after year. In her recent book Fired Up, Watts describes how she is bringing insights from that experience to a new mission: helping women identify their values, abilities, and desires and acting on them without waiting until everything is perfect. Tune-in to learn about:  The "false fires" women mistake for passion; Why losing estrogen and testosterone in midlife might actually make women braver, not less so; The one exercise she does with every woman she coaches.  Mentioned in this episode: Fired Up book Moms Demand Action If you like this podcast, please share it on your social channels. You can also subscribe to the series and check out all of our episodes at www.osmosis.org/podcast

Opie and Ronnie are only on the air because McPuffin dropped cash to stop the day off — cue military salutes and endless ball-busting. From "I talked to Mitch this morning" lies on CNN, to a NYC skyscraper literally bending like straws under luxury apartments, Manhattan sinking into the sea, David Lee Roth's legendary radio heist failure, and Messi's emotional World Cup miracle comeback that had everyone crying. Zero filter, constant tangents, chat chaos, and Tony P hate-watching from the sidelines. Classic Opie Radio morning mayhem.Donating to the show helps us make more! PayPal - opieradiohttps://www.paypal.com/ncp/payment/JANCGHFW7GJHA

Mark breaks down what led to the steel beams at the old Pfizer building in Midtown Manhattan being at risk of collapse due to buckling yesterday. There are rumors about whether a Russia-Ukraine deal could happen before the midterms. Politicians note that the way people express themselves on social media today is similar to pre-social media times, just with a larger audience now. Mark also explains what a safe deposit box is and why people use them at banks.See omnystudio.com/listener for privacy information.

Mike in Florida called in to share a light joke about the Pfizer building in NYC and reminisced about his time working in New York City as a stage manager. Richie in Connecticut called to discuss communism and its potential impact on the United States. He also talked about how socialism is being portrayed in the country and explained a law signed by Dwight Eisenhower years ago, considering how it might apply today.See omnystudio.com/listener for privacy information.

Mark breaks down what led to the steel beams at the old Pfizer building in Midtown Manhattan being at risk of collapse due to buckling yesterday. There are rumors about whether a Russia-Ukraine deal could happen before the midterms. Politicians note that the way people express themselves on social media today is similar to pre-social media times, just with a larger audience now. Mark also explains what a safe deposit box is and why people use them at banks. Mark takes your calls! Mark interviews TV personality, Rhonda Shear. She discusses her appearance on ABC's The View, airing today. Rhonda is interested in launching a celebrity podcast with Mark, and they share memories about classic TV and her past podcasts.See omnystudio.com/listener for privacy information.

Mark breaks down what led to the steel beams at the old Pfizer building in Midtown Manhattan being at risk of collapse due to buckling yesterday. There are rumors about whether a Russia-Ukraine deal could happen before the midterms. Politicians note that the way people express themselves on social media today is similar to pre-social media times, just with a larger audience now. Mark also explains what a safe deposit box is and why people use them at banks. Mark interviews TV personality, Rhonda Shear. She discusses her appearance on ABC's The View, airing today. Rhonda is interested in launching a celebrity podcast with Mark, and they share memories about classic TV and her past podcasts. The ceasefire between the U.S. and Iran appears to be over after both sides exchanged fire. President Trump vows a hard line in response, with no new negotiations expected. Talks about the U.S. acquiring Greenland may be resurfacing. Pressure is mounting for Maine politician Graham Plattner to resign. Jeopardy! has brought on a new clue writer after years with the same person. Mark interviews author Ann Coulter. Ann and Mark discuss the mindset of Democrats and socialists in the U.S., including Graham Plattner. They talk about the strong emotions in some left-leaning groups and concerns about the political backgrounds of many midterm candidates.See omnystudio.com/listener for privacy information.

Please see https://www.pfi.sr/HYMPAVZI_PI for Full PI. #HYMPAVZISponsored William S. Somers, Ph.D., was a biotherapeutics research and development leader with more than 30 years of experience across biotechnology and pharmaceutical organizations, including Pfizer. As a scientist living with hemophilia, Dr. Somers played a key role in driving the patient-centric and purposeful design of HYMPAVZI (marstacimab-hncq). This episode will explore how the patient perspective influenced the scientific journey, with a special focus on Will's research and why it was personally important for him to bring HYMPAVZI to people with hemophilia. HYMPAVZI may cause serious side effects, including blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. To learn more about this risk and additional safety information visit HYMPAVZI.com. This post is directed to a U.S. audience and may not be suitable outside of the U.S. This video is intended to be viewed as it was originally produced in partnership with Pfizer. Remember, this content is for educational purposes only and does not replace discussions with a healthcare provider. PP-HYM-USA-1267 Show Notes: For safety information visit: https://labeling.pfizer.com/ShowLabeling.aspx?id=20916&Section=PPI For information on how to navigate your treatment journey, visit the Shared Decision-making Guide here. Listen and subscribe where you get your podcasts! #Hemophilia IMPORTANT SAFETY INFORMATION Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products or "bypassing agents" (products that help blood clot but work in a different way than HYMPAVZI). Your healthcare provider may prescribe factor VIII or factor IX medicines or bypassing agents to treat episodes of breakthrough bleeding during your treatment with HYMPAVZI. Carefully follow your healthcare provider's instructions regarding when to use these medicines and the prescribed dose during your treatment with HYMPAVZI. Do not use additional doses of HYMPAVZI to treat breakthrough bleeds. Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you: have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery. have a severe short-term (acute) illness such as an infection or injury. have been told that you have a risk for blood clots. are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby. Females who are able to become pregnant: Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI. Use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI. are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. If you inject too much HYMPAVZI, call your healthcare provider or the Poison Help Line at 1-800-222-1222 or go to the nearest hospital emergency room right away. What are the possible side effects of HYMPAVZI? HYMPAVZI may cause serious side effects, including: blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. Blood clots have happened in people using HYMPAVZI. You may have an increased risk of blood clots if you have certain risk factors. Stop using HYMPAVZI and get medical help right away if you develop any of these signs or symptoms of blood clots: swelling or pain in your arms or legs redness or discoloration in your arms or legs shortness of breath pain in chest or upper back fast heart rate cough up blood feeling faint headache numbness in your face eye pain or swelling trouble seeing allergic reactions. HYMPAVZI may cause allergic reactions, including rash and itching. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction: swelling of your face, lips, mouth, or tongue trouble breathing wheezing dizziness or fainting  fast heartbeat or pounding in your chest  sweating The most common side effects of HYMPAVZI include: swelling, hardening, redness, bruising, bleeding, and pain at injection site headache fever joint pain  diarrhea  itching  rash  These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. What is HYMPAVZI? HYMPAVZI is a prescription medicine used regularly to prevent or reduce the frequency of bleeding episodes in adults and children 6 years of age and older with: hemophilia A with or without factor VIII inhibitors, or hemophilia B with or without factor IX inhibitors. It is not known if HYMPAVZI is safe and effective in people receiving ongoing Immune Tolerance Induction (ITI).  It is not known if HYMPAVZI is safe and effective in children younger than 6 years of age.

Breaking news from Manhattan: The old Pfizer building on 42nd Street started to buckle during construction, so it and nearby buildings were evacuated. President Trump is at the NATO summit today. He's given Iran several chances to make a deal, but Iran recently fired missiles near the Strait of Hormuz, which may jeopardize the ceasefire again. Tyler Robinson, who's accused of killing Turning Point USA founder Charlie Kirk, was in court yesterday and is back in a Utah courtroom today for more hearings. The NYC schools' budget might need an overhaul because of possible waste, and Zohran Mamdani is accused of shifting big money in the Department of Education budget.See omnystudio.com/listener for privacy information.

Breaking news from Manhattan: The old Pfizer building on 42nd Street started to buckle during construction, so it and nearby buildings were evacuated. President Trump is at the NATO summit today. He's given Iran several chances to make a deal, but Iran recently fired missiles near the Strait of Hormuz, which may jeopardize the ceasefire again. Tyler Robinson, who's accused of killing Turning Point USA founder Charlie Kirk, was in court yesterday and is back in a Utah courtroom today for more hearings. The NYC schools' budget might need an overhaul because of possible waste, and Zohran Mamdani is accused of shifting big money in the Department of Education budget. Mark takes your calls! Mark interviews streaming host Bill O'Reilly. Bill shares some details about his new book and warns about Zohran Mamdani's mindset, which he thinks is influenced by Mamdani's father. They also talk about how tech could be fueling communism both here and around the world, with Bill giving his take on how it all works.See omnystudio.com/listener for privacy information.

President Trump's idea for kids' savings accounts could be a big deal down the line. The U.S. men's soccer team is out of the World Cup after a loss to Belgium yesterday; Mark weighs in on FIFA. The war in Ukraine and Russia keeps dragging on, and there's talk about what both countries should really focus on. Graham Plattner looks like he's dropping out of the political race in Maine as Democrats back away. Power outages are still hitting New Jersey, and residents aren't happy. In addition, in New Jersey, a BJ's store had its roof collapse, which scared a lot of shoppers due to the recent storms. Mark interviews Boston radio host Howie Carr. They discuss whether Graham Plattner is really done in Maine politics. Howie gives his take on the state's political scene. There's a push from the communist movement that might be helping Republicans in the midterms. The Republican Party in Massachusetts has faded over time, and Howie talks about why. Breaking news from Manhattan: The old Pfizer building on 42nd Street started to buckle during construction, so it and nearby buildings were evacuated. President Trump is at the NATO summit today. He's given Iran several chances to make a deal, but Iran recently fired missiles near the Strait of Hormuz, which may jeopardize the ceasefire again. Tyler Robinson, who's accused of killing Turning Point USA founder Charlie Kirk, was in court yesterday and is back in a Utah courtroom today for more hearings. The NYC schools' budget might need an overhaul because of possible waste, and Zohran Mamdani is accused of shifting big money in the Department of Education budget. Mark interviews streaming host Bill O'Reilly. Bill shares some details about his new book and warns about Zohran Mamdani's mindset, which he thinks is influenced by Mamdani's father. They also talk about how tech could be fueling communism both here and around the world, with Bill giving his take on how it all works. See omnystudio.com/listener for privacy information.

//The Wire//2300Z July 7, 2026// //ROUTINE// //BLUF: EXPLOSIONS REPORTED NEAR HOTEL HOUSING FRENCH PRESIDENT DURING STATE VISIT TO DAMASCUS. MONACO BOMBER FOUND DEAD IN UKRAINE. IRAN RESUMES TARGETING OF UNAUTHORIZED TRANSITS OF HORMUZ STRAIT. CONCERNS GROWING REGARDING STATUS OF SENATOR MCCONNELL'S HEALTH, COMPLICATING UPCOMING ELECTION.// -----BEGIN TEARLINE------International Events-Syria: This morning several explosive devices were detonated in Damascus during French President Emmanuel Macron's state visit. The first device took the form of a Vehicle-Borne IED (VBIED) which was detonated on the street adjacent to the Ministry of Tourism, wounding many people including the Assistant Deputy Minister of Tourism. A few minutes after this device detonated, another device detonated on the street immediately adjacent to the initial blast site. At the time of the blasts, President Macron was staying at the Four Seasons hotel directly across the street from the blast site. Macron was not wounded during the attack, and has not canceled his state visit to Syria.Analyst Comment: This complex attack was very likely targeting Macron himself, or at least trying to get as close as possible to cause diplomatic trouble. Throughout the region, it's extremely common for terror groups to conduct attacks while foreign dignitaries are visiting, so as to embarrass their political leadership.Ukraine: Yesterday one of the lead suspects in the Monaco bombing case was found dead. Anastasiia Berezovska was the individual suspected of dropping off the bomb at the residence of Vadym Yermolaiev a few weeks ago. Berezovska was found at an undisclosed location in Ukraine with multiple gunshots to the head. After her death was discovered, an actively-serving member of the Intelligence Directorate of the Ukrainian MoD confessed to her murder.Analyst Comment: Very clearly, someone is tying up the loose ends in this case, and doing so very publicly to send a message. Now that the lead suspect in the bombing case is dead, the entire affair is tidied up neatly, and no further investigation can be undertaken regarding who Berezovska was working for.-HomeFront-Washington D.C. - Concerns are growing regarding the status of Senator Mitch McConnell, who has been hospitalized for several weeks. On June 14th, McConnell was found unconscious on the floor of his home in Capitol Hill after suffering an apparent heart attack. CPR was performed at the scene, and he was transported to a hospital. Apart from those initial details, there is currently no indication of his status beyond unconfirmed rumor.Analyst Comment: McConnell's health has been extremely concerning over the past few years, with several viral media incidents indicating that he is not well. In this case, three days after his heart attack, his wife Elaine Chao traveled to China to meet with Chinese Vice President Han Zheng. As a result of the timing of this visit, and the extreme secrecy surrounding the health of a man who has been of ailing health for years, concerns are growing regarding McConnell's status. In Kentucky, election law regarding position appointments has recently changed. Instead of the Governor being able to make an appointment for the seat, if a Senator dies in office, a special election is now mandatory. As such if McConnell passes away before the election, a special election would have to be held to fill the vacancy of only a couple of months, before the general election in November.However, the timing matters. If a Kentucky Senator dies in office (and thus vacates the seat) less than 63 days before the election, a special election would probably not be required and the normal election goes on. In this case, McConnell is not running again this year but the law regarding his seat still applies, so he must remain alive until September 1st, in order to prevent a special election which would allow a third-party candidate to run for his seat.New York: This morning evacuations were conducted after a high-rise building experienced a partial collapse in midtown Manhattan. The former Pfizer building at 235 E. 42nd St was undergoing major renovations/construction this morning, when approximately 5 floors of the building experienced a partial collapse. A perimeter cordon is currently in place around the building, as pieces of the structure have been falling on the street and sidewalk throughout the morning.-----END TEARLINE-----Analyst Comments: In the Persian Gulf, the Ayatollah's funeral has served as a sort of ceasefire-within-a-"ceasefire", and the United States and Iran took the past week to actually stop shooting at each other. During that time, merchant vessels also took the opportunity to slip through the Strait of Hormuz via the southern Omani route...something that Iran has repeatedly warned against. During the funeral, Iranian forces let this take place, however as of last night patience ran out and the Iranians have returned to striking commercial vessels for taking this route. So far today, a total of 4x confirmed (and probably one more unconfirmed) merchant vessels have been engaged by Iran for trying to sneak through the Strait. This is the most ships that have been struck since the hot-phase of the war, and these targeting efforts were not the result of ship captains unilaterally changing the route.Yesterday, the UKMTO directly stated that merchant traffic may take the southern route without coordinating with the Iranians. This statement was issued knowing full well that the Iranians have been warning ships that they must take the Larak Island route. Exactly who made the decision to issue this statement is unclear, but in effect the UKMTO told ships to take a route that they knew would be unsafe, gambling on the Iranians not conducting strikes during the Ayatollah's funeral. Now, the burning hulls of five ships are evidence that this gamble was ill advised. In response to these attacks, the United States has re-imposed sanctions on Iranian oil exports after granting them permission to export their oil a few weeks ago. Other than the sanctions, the United States is likely to conduct the standard retaliation strikes at random targets near Bandar Abbas over the next few days.Analyst: S2A1 Research: https://publish.obsidian.md/s2underground Disclaimer: No LLMs were used in the writing of this report. //END REPORT//

Ron Blaylock is founder of GenNx360 Capital Partners and former head of Blaylock & Company, leading over $150B in transactions and serving on major corporate and nonprofit boards including Pfizer and Carnegie Hall. Top 3 Value Bombs 1. Success isn't just hard work; luck plays a role, but consistent effort puts you in position to capitalize when opportunities arise. 2. Overlooked, "boring" industries often hold the biggest opportunities when paired with operational excellence and smart technology. 3. Enduring businesses are built by serving all stakeholders, employees, customers, and shareholders with long-term thinking. GenNx360 is a private equity firm driving value through Operational Engagement and Investment Excellence -GenNX 360 Capital Partners Sponsors HighLevel - The ultimate all-in-one platform for entrepreneurs, marketers, coaches, and agencies. Learn more at HighLevelFire.com. Nexus Install - Have a high-ticket offer? Nexus Install builds you a custom LinkedIn prospect booking system designed to generate more quality sales calls. Email JLD at John@EOFire.com to learn more. ZipRecruiter - Find candidates who really want YOUR job — on ZipRecruiter. Try it for free at ZipRecruiter.com/fire. Meet your match on ZipRecruiter. Framer - Learn how you can get more out of your site from a Framer specialist, or get started building for free today, at Framer.com/fire for 30 percent off a Framer Pro annual plan.