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Andrew Koutnik, PhD is a Research Scientist studying the influence of lifestyle and metabolism on health, disease, and performance. He originally began his research path at Florida State University (FSU) in Exercise Science. During his time at FSU, Andrew was trained in the Human Sciences Cardiovascular Laboratory studying the influence of nutrition, exercise, supplementation, and environmental extremes on health-based outcomes in normal and clinical populations across cardiovascular, autonomic, and skeletal muscle tissue systems. Andrew then transitioned to help assist and lead synergistic research efforts at FSU's Human Sciences Cognitive Cardiology Laboratory and FSU's College of Medicine Cardiac Biomedical Laboratory exploring the bi-directional impact of cognitive, mental, and prior brain injury status on tissue systems, risk factor modulation, and stress tolerance across pre-clinical and human subjects, including patients with prior cerebrovascular injury. While at FSU, Andrew received the Bess Ward Honor Thesis, Honors Medallion, and ACC Meeting of the Mind awards, and served as a Research Ambassador and Student Mentor for the Honors College and FSU's Student Council for Research and Creativity.Andrew was awarded the Presidential Fellowship to attend The University of South Florida where he received his doctorate in Biomedical Sciences with the Metabolic Medicine Lab in the Morsani College of Medicine (USF COM). At USF COM, Andrew's research focused on studying metabolism and metabolic therapies for health, disease, and performance outcomes. Specifically, Andrew explored how nutritionally induced (endogenous) and exogenous ketone body production (ketogenesis), utilization (ketolysis), and signaling modulated systemic metabolism and disease models of skeletal muscle atrophy, cancer, seizures, neurological disorders, among others. A central focus of this work surrounded the elucidation of systemic biomarkers and tissue-specific pathological signaling of nutritional ketosis using synthetic ketone bodies in the context of multifactorial acute and chronic oxidative and inflammatory insults. Andrew also extended efforts to test the biologic and performance impact of novel exogenous ketone formulations in high-level athletes. These efforts have expanded into highly trained operators as Andrew has organized multiple research projects on NASA NEEMO 22 & 23 studying the maladaptation response to extreme environments (hyperbaric) to uncover mitigative strategies to augment operator health and performance. While at USF COM, Andrew was the three-time recipient of USF's Research Award.Beyond his primary efforts, Andrew Koutnik was invited to give a TEDx talk on his personal journey using lifestyle and metabolic factors to manage Type-1 Diabetes for over 14 years. Andrew's journey with Type-1 Diabetes has given, and continues to give, an incredible in-depth perspective into the world of our metabolism, how it works, how day-to-day life (sometimes moment-by-moment choice) influences it, and how these changes on metabolism can have far-reaching effects over other aspects of our physiology. Andrew's unique experience as a metabolic researcher and Type-1 Diabetic created a strong appreciation for the role lifestyle and metabolism can play into health modulation, disease prevention, and disease management. Andrew currently is involved in advocacy, education, and research to improve health outcomes across populationsLinks discussedType 1 grit group on FB https://www.facebook.com/Type1Grit/Dr Bernstein's Diabetes Solution book https://www.amazon.com/Dr-Bernsteins-Diabetes-Solution-Achieving/dp/0316182699 Paper utilising LC diets for type 1 diabetes Andrew Koutnik https://www.andrewkoutnik.com/Paper outlining why carbohydrate restriction for type 1 diabetes: https://www.jci.org/articles/view/142246/pdf Andrew's TEDx talk https://www.youtube.com/watch?v=eDfgulV_F6o&ab_channel=TEDxTalks
In this episode we talk to Dr. Shawna Pandya. Dr. Pandya is a scientist-astronaut candidate with Project PoSSUM, physician, aquanaut, speaker, martial artist, advanced diver, skydiver, pilot-in-training, VP Immersive Medicine with Luxsonic Technologies and Fellow of the Explorers’ Club. She holds degrees in neuroscience, space, entrepreneurship and medicine, and is currently completing a fellowship in Wilderness Medicine. In 2015, Dr. Pandya completed scientist-astronaut candidate training with Project PoSSUM (Polar Suborbital Science in the Upper Mesosphere) and was on the first crew to test a commercial spacesuit in zero-gravity. She has flown over 140 parabolas in microgravity to date. Dr. Pandya is the lead instructor for Project PoSSUM’s EVA 102: Operational Space Medicine course and Director for Project PoSSUM’s Space Medicine Group. Through Project PoSSUM, she completed hypobaric hypoxia training, centrifuge studies, aerobatic flight, basic and advanced emergency spacecraft egress and sea survival training, and high altitude noctilucent cloud research. Dr. Pandya also completed a tour at the Mars Desert Research Station analog in Utah, both as Commander and as Crew Health & Safety Officer. In 2019, Dr. Pandya attained her aquanaut designation during a 5-day underwater mission (NEPTUNE) at the Jules Underwater Lodge, completed the World Extreme Medicine Hyperbaric and Dive Medicine Course at Aquarius Reef Base, where NASA NEEMO missions take place, and was named a fellow of the Explorers’ Club. Her adventures were recently captured in the Land Rover short, released with the Apollo 11: First Steps film. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/clayming-space/message Support this podcast: https://anchor.fm/clayming-space/support
Dr. Shawna Pandya is a citizen-scientist astronaut candidate with Project PoSSUM, physician, speaker, martial artist, advanced diver, skydiver and pilot-in-training. She holds degrees in neuroscience, space, entrepreneurship and medicine, and is currently completing a fellowship in Wilderness Medicine. In 2015, Dr. Pandya completed Scientist-Astronaut Candidate training with Project PoSSUM (Polar Suborbital Science in the Upper Mesosphere) and was part of the first crew to test a commercial spacesuit in zero-gravity; her work with Project PoSSUM and Final Frontier Design was captured in the CBC Documentary, “We Are Canada.” She has continued to test commercial spacesuits with Project PoSSUM’s annual microgravity parabolic flight campaigns, and has completed over 100 parabolas in microgravity to date. Dr. Pandya is also the lead instructor for Project PoSSUM’s EVA 102: Space and Wilderness Medicine course. As part of Project PoSSUM, she also completed hypobaric hypoxia training, centrifuge studies, aerobatic flight, basic and advanced emergency spacecraft egress and sea survival training, and high altitude noctilucent cloud research. Dr. Pandya also completed a 2-week tour at the Mars Desert Research Station analog in Utah as the Crew Health and Safety Officer. She has recently been named as an ambassador for the PoSSUM 13, an initiative to make space opportunities and engagement more accessible to students, particularly girls and young women. She also serves as the Chair of Strategic Development for this initiative. Dr. Pandya will be attaining her aquanaut designation with a mission to the Jules Verne Underwater Lodge later this year and successfully completed the World Extreme Medicine Hyperbaric and Dive Medicine Course at Florida International University’s Aquarius Reef Base, where NASA NEEMO missions take place, attaining her Dive Medical Technician designation in the process. Her adventures and experiences were recently captured in the Land Rover short, released with the Apollo 11: First Steps film. In her spare time, Dr. Pandya practices Taekwondo (as a second-degree black belt) and Muay Thai. She is currently working towards her private pilot’s license and holds her accelerated free fall solo skydiving license and numerous SCUBA diving certifications. Dr. Pandya also sings and plays the piano.
Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer and metabolic wellness. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. Time stamps 5:56 Nasa Neemo 23 17:38 Organization/entrepreneurship/ and prioritization. 19:38 Human Metabolism and the ketogenic diet. 29:07 Glucose Metabolism 31:06 Do we need glucose to run our body? 32:43 What changes in our body when we don't consume carbohydrates. 39:50 Medium chain triglycerides. 42:45 How do we adapt to ketosis? 44:52 Calorie restriction benefits of the ketogenic diet. 48:53 Neuro protective effects of ketones. 49:58 Anti-inflammatory mechanisms of ketones. 53:45 Histone deacetylase 56:40 Epigenome. 58:00 Krebs Cycle. 59:51 Mitochondrial Function with Ketones/oxidative stress. 71:17 Carbohydrate based metabolism and oxidative stress.. 72:55 Mean amplitude glucose excursions. 76:10 Glucose, inflammation , oxidative stress and insulin resistance. 77:20 The Warburg Effect 89:35 Mitochondria Damage or nucleus damage in regards to cancer. 92:37 Ketogenic diet and Mitochondria protection. 94:20 The most radical thing Dom has done recently. 95:45 Where to find Dom online/upcoming projects. Dom’s info: Instagram: dominic.dagostino.kt Twitter: DominicDAgosti2 Web: ketonutrition.org Ancestral Supplements https://ancestralsupplements.com/ use the promo code “SaladinoMD” on the shopify site for 10% off. JOOVV: www.joovv.com/paul My contact information: PATREON: https://www.patreon.com/paulsaladinomd SOCIAL MEDIA Instagram: @paulsaladinomd Website: paulsaladinomd.com Twitter:@mdsaladino Facebook: Paul Saladino MD email: paulsaladinomd@gmail.com Be sure to subscribe for more medicine and lifestyle content. Stay radical!
Dr. Dominic D’Agostino returns to STEM-Talk to give Ken and Dawn an update on his research into ketogenic nutrition. Dom was the guest on episode 14 back in 2016 when ketogenic diets didn’t even show up on a list of the top-10 diets that people Googled. Since then, the search term “ketogenic diet” has risen to the top of the list. In today’s episode, Dom talks about his past 10 years of research into ketogenic diets and what he is learning about the physiological benefits of nutritional ketosis. Dom is tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine.He also is a research scientist here at IHMC.Throughout his career, Dom has been a researcher with a diverse background in neuroscience, molecular pharmacology, nutrition and physiology. Show notes: [00:02:55] Dawn begins the interview mentioning that when she and Ken started hosting STEM-Talk, the ketogenic diet wasn’t on the list of the top-10 most Googled diets of 2015. Today, however, Dawn points that ketogenic diet is number one on the list. She asks Dom if he foresaw sudden mass interest in a ketogenic diet coming. [00:04:12] Ken asks Dom for his thoughts on how the ketogenic diet has went from being very obscure to becoming a household term. [00:06:04] Ken comments on the evolutionary component of the ketogenic diet and how our ancestors must have gone in and out of ketosis based on the availability of food. He also comments on the unique aspect of the ketogenic diet, being that it has an objective measurement, and asks Dom to talk about that. [00:06:59] Dawn comments on the cynicism regarding the ketogenic diet, particularly from nutritionists. She asks Dom to address the criticism and pushback that the ketogenic diet receives from so many nutritionists. [00:10:02] Ken mentions that some fields are resistant to change and new science due to the emotion behind established theories. Dom agrees and then talks about how people, even doctors, are resistant to new data and new science. [00:11:13] Dom talks about the most common misconceptions and overrepresentations of the ketogenic diet. [00:12:54] Ken discusses his dissatisfaction with the term “ketogenic diet” since the word diet implies the mandated consumption of certain food items. He goes on to say that if one is in ketosis, then, by definition, they are doing a ketogenic diet, even though they may be in ketosis because they have been fasting and haven’t eaten anything. Ken and Dom discuss how knowledge about ketogenic nutrition has changed over time and that it is certainly possible to eat an unhealthy ketogenic diet. [00:15:35] Dom and Ken talk about the results of a recent Megan Roberts paper, “A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice,”that showed a 13% increase in the lifespan of the mice along with remarkably improved healthspan. [00:20:26] Dom shares his thoughts on the potential of exogenous ketones in the context of blood glucose regulation. [00:27:07] Ken asks if Dom has been tracking Virta Health, which was founded by Dr. Jeff Volek who was interviewed in STEM-Talk episode 43. Virta Health has been publishing impressive results of its trials that show people reversing type-2 diabetes via a well-formulated ketogenic diet. [00:29:13] Ken adds that the reported numbers from Virta show 60% to 70% of their patients going off their insulin medication or greatly reducing their insulin levels. [00:30:55] Dawn asks about Dom’s experience going underwater for 10 days in participation of a NASA NEEMO mission. She asks him to talk about his personal experience as well as his background in hyperbaric physiology. [00:32:08] Dom discusses his group’s work replicating the experimental design of his original oxygen toxicity work in aged and obese rats. [00:33:35] Dawn briefly describes what oxygen toxicity is,
Our special guest is Dominic D'Agostino, Ph.D. Dom is an Assistant Professor at the College of Medicine Molecular Pharmacology & Physiology at the University of South Florida. He works to develop and test nutritional and metabolic therapies including ketogenic diets and ketogenic agents for CNS oxygen toxicity (seizures), epilepsy, metabolic disorders, Alzheimer's disease, ALS, muscle wasting and cancer. He is a senior research scientist at the Institute for Human & Machine Cognition. Dom was also recently a member of the NASA NEEMO 22 project.You will learn plenty from Dominic D'Agostino in episode 172 of The Vision Board Podcast.Get your FREE copy of CONVERSATIONS WITH CHAMPIONS, an inspirational quote book of all the guests from the podcastSimply visit http://www.thevisionboardpodcast.com/ebookGet in touch with Jonny and Tristan at info@thevisionboardpodcast.com
Dom D'Agostino, Ph.D., is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He was also recently a crew member of the NASA NEEMO 22 project.
Dom D'Agostino, Ph.D., is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He was also recently a crew member of the NASA NEEMO 22 project.
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