Podcasts about ketogenic

Send us Fan MailDr. Austin Dudzinski is a Clinical Pharmacist at Think Whole Person Healthcare, and enjoys working with cardiometabolic disorders, especially diabetes and dyslipidemia.Think Whole Person Healthcare partners with physicians in many areas of care, keeping primary care, specialists, and diagnostics all under the same roof, saving their patients time, emotional effort, and money.What Dr. Dudzinsky finds most exciting about working in Medicine is that there are always innovations on the horizon, especially in preventive medicine for diseases such as cancer and dementia. He has known he's wanted to work in this field since college.What Dr. Dudzinski loves most about working at think is that it provides him with the opportunity to use the entire body of knowledge that he has learned and apply it to help patients. If asked, he thinks his patients would say he's, “The bald pharmacist that calls them about their diabetes.”When he's not at work, he enjoys playing guitar, exercising, reading medical literature, and hanging out with his wife and son.Find Dr. Dudzinsky at-TW/X- @ApoDudzhttps://thinkhealthcare.org/Find Boundless Body at-myboundlessbody.comBook a session with us here! 

Send us Fan MailDr. Jodi Nishida is a returning guest on our show! Be sure to check out her first appearance on episode 721 of Boundless Body Radio!Dr. Jodi Nishida is a Doctor of Pharmacy and accredited Metabolic Healthcare Practitioner who has been in healthcare for over 30 years. After experiencing the ketogenic lifestyle's effect on her own autoimmune condition, she decided to build a keto-based medical practice called The Keto Prescription so others could benefit from it too.Over the last several years, she has helped thousands of patients realize the benefits of clean, medically guided keto. With an accreditation in ketogenic nutrition; certifications in cardiovascular disease management, pharmacogenomics, and medication management; and first-hand experience working in gastrointestinal clinics and women's health clinics, Jodi works closely with each patient to tailor keto to their medications, medical conditions, lifestyle, and socioeconomic situation.Health is not a one-size-fits-all approach, and we all have unique challenges. Because all of us are addicted to sugar and processed food to some extent, fueled largely by our food industry, she has also partnered with two highly qualified psychologists locally, to help her patients address the root of their eating behaviors.She is also the owner of her latest venture, Rise Cafe, located in Honolulu, HI! The coffee shop is an offshoot of her medical practice where she can proudly bring low carb, no sugar items to the people of Hawaii. Rise Cafe is their combined effort to improve the health of those who visit!Find Dr. Jodi Nishida at-https://weloverise.com/IG- @theketoprescriptionhttps://www.theketoprescription.com/Check out the HILAROUS reviews on Yelp!Find Boundless Body at-myboundlessbody.comBook a session with us here! 

Today we have Dr. Dominic D'Agostino, who over the past 10 years has been a frequent guest on STEM-Talk. Today Dom joins us to give us an update on his recent research into ketogenic metabolic therapies, ketone supplements as well as hyperbaric oxygen therapy for traumatic brain injuries. Dom and his lab at the University of South Florida have published more than 20 papers since his last appearance on STEM-Talk in 2023. Dom is an Associate Professor in the Department of Molecular Pharmacology and Physiology at South Florida's Morsani College of Medicine. Dom has a background in neuroscience, molecular pharmacology, nutrition and physiology. In addition to developing and testing metabolic-based therapies, Dom's lab also investigates seizure disorders, brain cancer, neurodegenerative diseases and rare genetic-metabolic disorders. Show notes: [00:03:28] Dawn welcomes Dom back to the show and explaining that he has been quite busy since his last appearance, authoring or co-authoring more than 20 papers. Over the past several years, Dom has been helping to advance the science and application of ketogenic metabolic therapy (KMT) with colleagues at Moffitt Cancer Center, particularly focusing on using KMT to enhance immune-based therapies for certain types of cancers. Dawn asks Dom about this collaboration. [00:05:04] Dawn explains that ketogenic metabolic therapy is a dietary approach that focuses on a high-fat/low-carb diet to reduce glucose availability for cancer cells, potentially slowing their growth and improving treatment outcomes. It has been explored as a complimentary treatment for a variety of cancers including gliomas by shifting the metabolism of tumor cells away from glucose. Dawn asks Dom to explain what is involved in KMT. [00:06:58] Dawn clarifies that KMT requires less than 20-25 grams of carbohydrates per day, and that ketosis is a metabolic state in which the body switches from glucose metabolism to metabolizing fats in the form of ketones. Dawn goes on to explain that cancer cells typically consume glucose at a higher rate than normal cells. However, cancer cells are also very adaptable, and Dawn asks Dom to talk about this feature of cancer cells. [00:09:14] Ken explains that KMT has shown the most promise in treating high-grade gliomas, or brain cancers, such as glioblastoma, which is the most aggressive primary brain tumor in adults. Ken explains that Dom was part of a massive review titled “Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma,” which proposed guidelines for the management of glioblastoma based on an understanding of cancer as a metabolic disease, particularly involving mitochondria. Ken asks Dom to talk about this review. [00:11:21] From a patient advocacy perspective, Ken notes that the review recommends that there should be an aggressive education campaign that can arm patients with knowledge about KMT and other novel therapies. Ken asks Dom to talk about that recommendation. [00:13:15] Ken asks about the process of cutting the review from upwards of 200 pages down to around 50 pages with 49 authors. [00:15:04] Dawn mentions that Dom was part of another paper in 2024 titled “Targeting the mitochondrial stem cell connection in cancer treatment – a hybrid orthomolecular protocol.” Dawn explains that this paper looked at the mitochondrial stem cell connection theory (MSCC), which argues that cancer originates from chronic oxidative phosphorylation insufficiency in stem cells. This insufficiency leads to the formation of cancer stem cells and abnormal energy metabolism ultimately resulting in malignancy. There were 16 research centers and organizations involved in this paper which introduced a hybrid orthomolecular protocol to target the mitochondrial stem-cell connection. Dawn asks Dom to give an overview of MSCC. [00:18:26] Dawn explains that in this paper Dom and his co-authors propose a protocol that would enhance oxidative phosphorylation and inhibit the primary fuels of cancer, glucose and glutamine. This would target both cancer stem cells and metastasis. Dawn asks Dom to explain why this concept is attracting so much interest as a potential therapeutic approach for cancer. [00:20:48] Dawn asks if Dom could discuss the orthomolecular protocol, which is an approach that focuses on preventing and treating diseases by correcting nutritional balances in the body. [00:24:41] Ken asks if the proposed dietary intervention in the orthomolecular approach is different from a standard or typical ketogenic diet. [00:26:48] Ken shifts the discussion to talk about ketone supplements, explaining that Dom recently published a paper titled “Divergent hepatic outcomes of chronic ketone supplementation.” Ken goes on to explain that ketone salts preserve liver health, while some ketone esters and precursors appear to drive inflammation and steatosis. There is a lot of interest in ketone supplementation because they substantially elevate circulating ketones without having to restrict carbohydrates as strictly. The problem, as Ken explains, is that the long-term hepatic safety of ketone supplements remains unclear. In the aforementioned paper, Dom's rodent study evaluated the formulation-dependent impact of chronic ketone supplementation on liver histopathology, inflammatory signaling and systemic biomarkers. Ken asks Dom to discuss this paper and its findings and to give an overview of the various ketone supplements currently available. [00:30:49] Dawn asks Dom to dive into the methods and findings of the rodent study. [00:34:36] Ken asks Dom what his confidence is in the rodent model used in this study, and what are the next step for further research. [00:37:47] Regarding the two different doses given to rats in the study, Ken asks Dom how these doses correlate to doses in humans [00:40:23] Ken mentions that Ben Bikman, who was our guest on episode 143, published a study in February which Dom helped co-author. It examined the effects of ketone supplements on liver function. Ken asks Dom to discuss this study. [00:44:38] Dawn pivots to ask about a joint paper that Dom did with Andrew Koutnik, who was our guest on episode 185, on carbohydrates and physical performance titled “Carbohydrate ingestion on exercise metabolism and physical performance.” Dawn asks Dom to talk about this paper, which showed that a small amount of carbohydrates is sufficient to fuel athletic performance, and how additional carbohydrate intake showed diminishing returns. [00:49:18] Ken follows up on the finding that endurance athletes who rely on carb loading can tend toward pre-diabetes. [00:51:39] Ken asks Dom about the University of South Florida trial that Dom is an advisor for on traumatic brain injury and hyperbaric oxygen therapy. [00:54:41] Dawn mentions that Dom recently had an editorial in Frontiers that gave an overview of the emerging applications of hyperbaric/hyperbaric-oxygen therapy in the treatment of different neurological disorders. Dawn asks Dom what the key points in that editorial were. [00:59:06] Dawn explains that Dom recently gave a lecture at IHMC (available to view on IHMC's YouTube page), on traumatic brain injury and the populations at greatest risk in that context. Dawn asks Dom to give an overview of how an injury to the brain can result in neurometabolic crisis. [01:02:53] Ken asks Dom, excluding occupation demographics, what demographic is most at risk for traumatic brain injury (TBI) and why. [01:04:45] Ken mentions that it is understandable the risk that young people face with TBI due to the activities that young people engage in. Older people, however, have increased risk of TBI from falling as well as an additional age-related biological component that young people are not subject to. Ken asks Dom to elaborate on this. [01:07:12] Dawn mentions that several years ago, Dom and his wife bought some acreage in the countryside and started farming and asks Dom how the farm life is going. [01:07:57] Dawn closes the interview asking how Dom's wife is doing.

Medical ketogenic therapy has more than 100 years of evidence behind it - so why is it still often treated as a last resort?! Ketogenic dietitian Neha Kaul explains how success can go beyond potential seizure reduction, and how the diet may affect cognition, mood and overall quality of life. Neha also covers common misconceptions, safety concerns, and what it really takes to make the diet work in everyday life.This episode is sponsored by Kanso, a brand by Dr. Schär and had no influence over the editorial content or discussion. Learn more about Kanso here: kanso.com/enChapters

How many carbs should you eat on a ketogenic diet? Do ketone levels matter? And why do cravings hit so hard? Is Dairy recommended?In this Metabolic Mailbag episode, registered dietitian and medical student Temple Stewart breaks down some of the most common challenges people face when starting and maintaining a ketogenic diet, especially for PCOS (PMOS), metabolic health, and long-term sustainability.Temple brings a unique perspective to this conversation, combining clinical nutrition experience with current medical training and a deep focus on women's metabolic health. Her approach is practical, individualized, and grounded in helping people build strategies they can realistically sustain over the long term.In this episode, we cover:Ketogenic therapy and the menstrual cycleCravings and the “sugar dragon”PCOS and therapeutic ketone levelsDairy, protein, and hungerVegetarian keto challengesCGMs and ketone testingHow to personalize a ketogenic approach long termOne of the biggest takeaways: successful ketogenic therapy is about understanding your own metabolism, building sustainable habits, and learning which strategies help you feel your best over time.

Kristina Cook shares how lifelong anxiety and postpartum depression, combined with her daughter Genevieve's escalating, unpredictable mood instability, rage, suicidality, and mania, pushed their family into crisis despite years of therapy, medications, and an 11-year-old's 16-week hospital in-treatment stay with a discharge plan involving notifying police. After an RFK Jr. press conference led her to Casey and Calley Means' message in Good Energy, Kristina removed ultra-processed foods and refined ingredients and saw rapid improvements in sleep, pain, and her daughter's behavior. Later, after hearing Dr. Chris Palmer describe ketogenic therapy for severe mental illness, Kristina and her daughter transitioned to keto, endured a brief detox period, and then experienced dramatic mental clarity; Genevieve reached remission and came off medication, and Kristina also saw major weight and anxiety relief. Kristina now studies nutrition, works with the Metabolic Collective, and advocates for accessible metabolic therapies for families. Good Energy (book by Casey Means & Callie Means)  metaboliccollective.org  Metabolic Mind — https://www.metabolicmind.org/ Kristina on X (Twitter): @KristinaCook https://x.com/KristinaCo9561 The Better Humans Project — Kristina's Instagram and Facebook pages  https://www.instagram.com/thebetterhumansproject?igsh=MTM4YTkyZ3duejdjbw==

Dr. Ian Lake has worked as a doctor in the NHS for nearly four decades, most of this time as a general practitioner. After being diagnosed with LADA Type 1 Diabetes at age 36 and managing it conventionally for 20 years, he adopted the low carb diet and has been following it for the past 10 years. He is a founding member of the Public Health Collaboration in the U.K. and has conducted several important research projects investigating the connection between low carb diets and human health. He has also worked with Dr. Tro and others to produce the Type 1 Consensus Statement. In this episode, Drs. Tro and Ian talk about… (00:00) Intro (03:30) The mental and physical health challenges faced by Type 1 Diabetics and how these challenges have traditionally been dealt with (13:44) Ketoacidosis, what insulin does, and modern methods/dietary reccomendations for controlling Type 1 Diabetes (25:45) How Dr. Lake's colleagues have responded to his ideas regarding Type 1 and ketogenic diets (38:00) Dr. Lake's new book, Shifting Gears, on the need to move from a glucose-centric view of Type 1 to a holistic, healthy human being perspective (50:23) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Resources Mentioned in this Episode: Dr. Ian Lake's last appearance on the LCMD Podcast: https://lowcarbmd.com/podcast/episode-368-dr-ian-lake/ Dr. Ian Lake: X: https://twitter.com/idlake Type1Keto: https://type1keto.com Type 1 Consensus Statement: https://journalofmetabolichealth.org/index.php/jmh/article/view/100 Case report: Ketogenic diet alleviated anxiety and depression associated with insulin-dependent diabetes management: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1404842/full Shifting Gears (New Book): https://type1keto.com/product/shifting-gears-the-1000-mile-ride-that-changed-my-mindset-on-type-1-diabetes/ Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://toward.health Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://toward.health/community/

What if the most powerful tool for mental health recovery isn't a medication — it's your metabolism?  Dr. Erin Louise Bellamy joins Dr. Vera Tarman for a deep dive into ketogenic metabolic therapy: what it is, how it works, and why it may be one of the most underutilized interventions in both psychiatric care and food addiction recovery.  Dr. Bellamy is a chartered psychologist, CEO of IKRT (International Ketogenic Research & Therapy), and a research fellow at the University of East London. She has been researching and applying ketogenic metabolic therapy in clinical settings since 2014, with a background that bridges eating disorders, psychiatric research, and metabolic health.  In this episode, Vera and Erin discuss:  How Erin went from eating disorder and alexithymia research to ketogenic metabolic psychiatry — and why the field's "biopsychosocial" model was missing the bio  The difference between metabolic psychiatry, ketogenic therapy, and therapeutic carbohydrate restriction — and why the terminology matters  What carbohydrate range actually produces therapeutic ketosis (and why "dirty keto" doesn't cut it)  The shared mechanistic pathways across psychiatric diagnoses — including mitochondrial dysfunction, insulin resistance, and neuroinflammation  Why antipsychotic medications create metabolic dysfunction, and how ketogenic therapy can help offset those side effects  The GABA/glutamate shift that makes ketones naturally anxiolytic — and why this may work differently than the serotonin model of depression  The "buffer effect": what it feels like to be in ketosis when you're a food addict — and why some people describe it as a pane of glass between themselves and a trigger food  How ketogenic therapy compares to GLP-1 medications (Ozempic/Wegovy) for reducing food noise — and Erin's concerns about the long-term research  MCT oil vs. exogenous ketones: when each is useful, and when exogenous ketones are counterproductive  Applying ketogenic therapy to people with ADHD, bipolar disorder, and co-occurring food addiction  How to support vegan or plant-based clients who want to pursue ketogenic therapy  Why the first week matters most — and how to help clients through withdrawal without triggering a binge  The 19-person IKRT group program published in Frontiers — and what's coming next in the research  Connect with Dr. Erin Bellamy:  

In today's episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue.We'll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You'll discover why bagfuls of supplements aren't enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins.Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromesTo become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 Factors affecting mitochondrial function03:55 Optimizing patient bioenergetics basics09:27 Mitochondria and cell evolution12:33 Focus on acquired mitochondrial dysfunctions14:23 Mitochondrial ATP production process20:22 Ketogenic diet and energy pathways21:15 Ketogenic diet for chronic fatigue27:02 Exploring functional medicine resourcesSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

This episode of Gobsmacked! features Ruth Mary Chipperfield, an award-winning jeweller whose gold jewellery has sat alongside some of the most celebrated names in history.Diagnosed with narcolepsy in her early twenties whilst studying chemistry at university, Ruth found herself facing a future very different from the one she had imagined. Powerful drug regimes solved one problem whilst creating others, and as a newlywed she was confronted with a stark reality, mainstream working life simply was not going to fit.But Ruth has done something remarkable.Instead of allowing narcolepsy to define the boundaries of her life, she transformed her scientific mind, her fascination with gemstones and her artistry into something beautiful. Today, she creates and repurposes exquisite jewellery, breathing new life into old treasures whilst building a life that works with her condition rather than endlessly battling against it.Like the facets of a beautifully cut diamond, this conversation refracts in so many fascinating directions. Chemistry. Gemstones. Ketogenic living. Punishing medication. Endurance. Reinvention. Identity. Survival.At one point Ruth says:“I've chosen my hard.”Blimey, she is articulate.And this really is an absolute must-listen. Hosted on Acast. See acast.com/privacy for more information.

Send us Fan MailGavin Symes is a returning guest on our show! Be sure to check out her first appearance on episode 776 of Boundless Body Radio!Gavin Symes is Registered Occupational Therapist, a Metabolic Therapy Coach, and the Founder & Chief Wizard of Wizard OT, short for Occupational Therapy. He founded Wizard OT in 2020 to provide a truly person-centered approach to therapy.At the core of their approach is the idea that each person should be treated as an individual. By considering each person's biological, psychological and social needs, they provide a tailored approach to improving every client's wellbeing. They don't assume to know ahead of time what is best for their clients, and instead, work with the individual, their family and their wider network to create an intervention.In 2010, Gavin suffered a serious head injury that left him physically and cognitively impaired. The injury made simple tasks hard and required some basic skills to be relearnt. Progress was slow and hard-won but with time, support and consistent effort, he was able to make a full recovery. The experience of having his life turned upside down by a debilitating impairment has informed everything Gavin has done throughout his career, as it is the fire that drives him to help others.Find Gavin at-https://www.wizardot.com/IG- @wizard_otFind Boundless Body at-myboundlessbody.comBook a session with us here! 

What if your body could warn you before a relapse happens? In this fascinating episode, Dr. Vera Tarman sits down with Bob Messerschmidt — biomedical engineer, inventor, and one of the architects behind the original Apple Watch's health-sensing technology — to explore a surprisingly simple but powerful biomarker: the erythrocyte sedimentation rate (ESR). Bob is the founder of Core Health and has developed an FDA-registered at-home device that tracks chronic low-grade inflammation over time. For those of us in the food addiction and recovery world, this conversation opens a compelling new door: could inflammation tracking be the missing feedback loop for people working to stay abstinent from ultra-processed foods?

This podcast explains how the body maintains stable blood glucose levels while following a carbohydrate-free ketogenic diet. Since the metabolism of fatty acids produces acetyl-CoA, which cannot be converted into glucose, the body must rely on other mechanisms to fuel the brain and red blood cells. Hormones like glucagon and epinephrine trigger the liver to activate gluconeogenesis, a process that synthesizes new sugar. Because fats are ineligible for this conversion, the liver utilizes the carbon skeletons of amino acids derived from dietary protein to create glucose. Ultimately, the high protein content of a keto diet is essential for replenishing glycogen stores and ensuring the body has a consistent energy supply.

Ketogenic diets can help some obese people lose a significant amount of weight when their health is at risk. But in recent months, social media influencers have also credited these very low-carb diets with a far more remarkable effect: treating, or even curing, schizophrenia. Is there any truth to this claim, or is it just another social media fad racing ahead of the evidence?

Send us Fan MailJohn LaSpina is a returning guest on our show! Be sure to check out his appearances on episodes 575, 582, 606, 718, 834, and 912 of Boundless Body Radio!John LaSpina, known online as Carnivore Teacher Alpha, is a retired educator, nutrition researcher, and creator of the popular Carnivore Teacher platforms where he teaches people around the world about the proper human diet and metabolic health.After spending more than three decades in the classroom teaching middle school, John turned his passion for education toward nutrition science, human biology, and the hidden chemistry of modern food.Through his books, interviews, and videos, he helps people understand how ultra-processed foods and plant toxins can affect the body-and how returning to nutrient-dense animal foods can restore health and vitality. John lives in Florida with his husband Doug and continues to teach, write, and share what he learns with a growing global community.He is the author of several books, including The Carnivore Teacher: A Meat-Based Education for Total Transformation, Processed To Death: The Truth About Ultra-Processed Food and How to Escape Its Grip, and his latest book Beyond Oxalates: The Complete Guide to Plant ToxinsFind John at-YT@- Carnivore Teacher AlphaIG- @carnivoreteacherjohnLK- @Carnivore TeacherFind Boundless Body at-myboundlessbody.comBook a session with us here! 

People with treatment-resistant depression and anxiety are seeing real improvements through ketogenic therapy. Now there's real-world clinical data to back it up.In this interview, Dr. Bret Scher sits down with Dr. Erin Bellamy to discuss her newly published findings from a clinical program bringing ketogenic therapy into everyday mental health care.While this was not a randomized controlled trial, the results offer an important look at how these interventions may work in everyday clinical practice, with meaningful improvements reported across both depression and anxiety measures.In this conversation, you'll learn:What the study found and how to interpret the resultsThe difference between real-world evidence and randomized trialsWhy some individuals were able to achieve clinically meaningful improvements, including remissionThe role of structure, education, and ongoing support in implementing ketogenic therapyCommon challenges people face and how group support can help navigate themHow ketogenic therapy can be personalized based on individual needsThe real-life improvements participants experienced in mood, anxiety, daily functioning, and quality of lifeDr. Bellamy also shares powerful insights from her clinical experience, including how individuals with long-standing, treatment-resistant symptoms were able to make meaningful lifestyle changes, challenging the idea that people with mental health conditions cannot adhere to dietary interventions.Looking ahead, Dr. Bellamy is launching a new study through the Metabolic Psychiatry Scholar Award to further explore and scale this approach.Learn more about the impact of metabolic therapies on depression and mood disorders on our Depression Topic Page: https://www.metabolicmind.org/resources/topics/keto-for-depression/

Send us Fan MailNicole Laurent is one the most featured returning guest on our show, so be sure to check out all her appearances on episodes 248, 343, 438, 538, and 744 of Boundless Body Radio!Nicole Laurent, LMHC, has been a licensed mental health counselor in Washington state for almost two decades. Her current practice focuses on helping her clients with anxiety, depression, and other mental health issues transition to a ketogenic diet or uses other nutritional therapies to complement their psychotherapy work.She holds several specialized training certifications, allowing her to work with underlying biological factors in mental illness. Nicole works with clients via telehealth, and helps people explore medication-free options for their mental health using research and evidence-based nutritional and functional psychiatry so that people can get their lives back without side effects or dependence on big pharma.In 2021, she created MentalHealthKeto.com, a blog devoted to educating people about ketogenic diets for mental health and neurological issues.Nicole is one of seven pioneers of Metabolic Psychiatry recognized by the Baszucki Brain Research Fund and the Milken Institute and has been given the Metabolic Mind Award in 2022Find Nicole at-https://mentalhealthketo.com/Study- Awareness and best practices in using ketogenic therapy to treat serious mental illness: a modified Delphi consensusIG- @mentalhealthketoTW- @KetoCounselorLK- Nicole Laurent, LMHCFB- @thatketocounselorFREE E-BOOK!Google Scholar link set with keyword "ketogenic"!Find Boundless Body at-myboundlessbody.comBook a session with us here! 

Are we destined for cognitive decline as we age, or do we have more control than we think?In this conversation, Dr. Bret Scher sits down with neuroscientist and researcher Dr. Tommy Wood to explore a powerful shift in how we think about brain health, aging, and dementia prevention.Dr. Wood challenges the common belief that cognitive decline is inevitable, highlighting how lifestyle, environment, and daily habits can meaningfully shape our brain's trajectory over time. He introduces his “3S Framework”—Stimulus, Supply, and Support—to explain how brain function is built, maintained, and optimized across the lifespan.In this interview, you'll learn:Why cognitive decline isn't inevitableHow mindset and engagement can influence brain agingThe role of metabolic health and energy supply in brain functionHow nutrition, sleep, exercise, and social connection interact to support the brainWhere ketogenic therapy and ketones may fit into brain health and cognitive declineHow to navigate modern challenges like technology, AI, and information overload from a brain health perspectiveDr. Wood also shares insights from his upcoming book, The Stimulated Mind, offering a practical framework to help individuals “future-proof” their brain and stay sharp in an ever-changing world.The key takeaway: brain health isn't about a single intervention. It's about consistently engaging, fueling, and supporting the brain in ways that promote resilience over time.

Send us Fan MailDr. Maya Schumer is a psychiatric neuroscientist and postdoctoral fellow at McLean Hospital and Harvard Medical School, and she is a first-time guest on Boundless Body Radio!Dr. Schumer's work focuses on understanding the brain network dynamics underlying bipolar disorder, particularly mania. Dr. Schumer's path is both professional and personal, as she has lived with bipolar disorder for over a decade. After years of persistent symptoms despite extensive treatment, she began exploring metabolic approaches to mental health, including ketogenic therapy, which profoundly changed her own trajectory.This lived experience informs her scientific work and advocacy, where she is passionate about bridging the gap between research and real-world healing. In addition to her research, Dr. Schumer is actively involved in national and international efforts to integrate lived experience into psychiatric science.She serves on committees within the International Society for Bipolar Disorders and the Society of Biological Psychiatry, and she is dedicated to advancing more personalized, biologically grounded approaches to mental health care.Through her research and public speaking, Dr. Schumer aims to expand how we understand and treat bipolar disorder—bringing together neuroscience and lived experience to help others find more effective paths to remission and stability.Find Dr. Maya Schumer at-TW- @MayaSchumerLK- Maya SchumerGoogle ScholarNY Times Article- Can the Keto Diet Really Improve Mental Health?Find Boundless Body at-myboundlessbody.comBook a session with us here! 

Send a textMitochondria in human evolution, climate adaptation, maternal genetics, aging, and disease.TOPICS DISCUSSED:Endosymbiotic theory: Mitochondria arose from oxidative bacteria engulfed by archaea-like hosts, confirmed by phylogenetic analysis.Maternal mtDNA inheritance: Mitochondrial DNA is inherited from the mother, not the father. There are adaptive reasons for this.Haplogroups & adaptation: Tropical lineages tightly couple energy production for efficiency; northern ones uncouple to generate heat.Heteroplasmy & aging: Mixed mutant and normal mitochondria accumulate in cells, eroding energy in high-demand tissues like brain and heart.Bioenergetics in disease: Many common conditions, from Parkinson's to cancer, stem from mitochondrial-nuclear interactions rather than nuclear genes alone.Ketogenic diets: High-fat intake fuels mitochondrial beta-oxidation, which may compensate for brain energy deficits in epilepsy and bipolar disorder.Warburg effect: Cancer cells shift to glycolysis to prioritize biosynthetic building blocks over maximal ATP production.Modern mismatches: Global travel pairs ancestral mtDNA with mismatched diets and climates, raising risks for metabolic dysfunction.ABOUT THE GUEST: Douglas Wallace, PhD is a geneticist and evolutionary biologist who has studied mitochondria for over 50 years. He currently directs the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia and the University of Pennsylvania.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Ketogenic therapy for schizophrenia, bipolar disorder, and depression is gaining attention, but how can it be safely implemented into clinical practice?A newly published expert consensus provides practical recommendations to help clinicians thoughtfully apply ketogenic metabolic therapy (KMT) for serious mental illnesses.In this in-depth conversation, Dr. Matt Bernstein and Dr. Georgia Ede, both members of the expert committee, discuss how this Delphi consensus was developed, what it includes, and how it can be responsibly integrated into psychiatric practice.In this interview, they discuss:What a Delphi process is and why it was usedThe results of the Delphi process (33 consensus statements and 10 clinical recommendations)Who may be appropriate candidates for KMTAbsolute and relative contraindicationsRecommended laboratory screening and monitoringHow long a trial should last before assessing efficacyHow clinicians can personalize implementation safelyImportantly, the authors emphasize that ketogenic metabolic therapy is not a replacement for standard psychiatric treatment. Rather, it may be considered alongside first-line therapies, particularly for individuals who have not responded adequately, cannot tolerate medications, or are seeking additional options.Reflecting on the value of this work, Dr. Bernstein shares:“I would have loved to have read this six years ago when I was starting to think about implementing these types of practices. It would have given me confidence to charge forward… I probably would have been further along now than I am.”With randomized controlled trials ongoing and more research expected in the coming years, this consensus provides a thoughtful, experience-informed framework for clinicians who are seeing growing interest in metabolic approaches.If you are a clinician, we encourage you to read the full publication.If you are a patient or family member, consider sharing this interview and the paper with your care team to support an informed discussion about whether metabolic strategies may be appropriate in your individual case.As always, clinical decisions should be made in partnership with qualified healthcare professionals.

Send a textRosemary Laberee, aka “Ro”, has been married to her husband Pete for 35 years, and they have 4 grown kids and a grandson. Her undergraduate degree is in business, and she has a master's degree in health science. She is also senior fitness certified and a certified osteoporosis peer educator.At age 60, Ro set out to reverse osteoporosis, something her doctor had said was impossible, and they were wrong. After encountering many women who had been told that there was nothing they can do besides taking medications, she decided to take her story to Instagram. She now has a growing audience eager for information about what lifestyle changes they can make to move the needle in the right direction when it comes to bone health.Recently, she retired from her work as a consultant in a nationally acclaimed pediatric research institute in order to devote more time to building her Instagram following and spreading the word on her motto- “Build bones now; ask me how!” In her spare time, she lifts weights, reads books, and continues to learn more about human biology.Find Ro at-IG- @coffeebooksbarbellsEmail- bonebodyrecomp@gmail.comFind Boundless Body at- myboundlessbody.com Book a session with us here!

How can doctors, psychiatrists, and other health practitioners implement keto for serious mental illnesses like schizophrenia, bipolar disorder, and depression?In this short interview, Dr. Bret Scher sits down with Dr. Georgia Ede to discuss a newly published Delphi consensus paper in Frontiers in Nutrition, authored by eight experienced clinicians and researchers to establish best practices for the use of ketogenic metabolic therapy (KMT) in serious mental illnesses.Using a structured expert consensus process, the group created 33 statements clarifying things like:What ketogenic metabolic therapy isWho may be appropriate candidates?Safety considerations and medical screeningMonitoring standards and clinical implementationHow KMT can be integrated alongside standard psychiatric careThese statements were then brought to a larger group of experienced clinicians to assess broader consensus, which resulted in all 33 statements reaching the consensus threshold.This paper is not a set of formal treatment guidelines. Instead, they represent an important first step in delivering practical, experience-informed guidance for clinicians who are seeing growing patient interest in metabolic approaches to serious mental illnessAs research continues to evolve, this consensus provides a thoughtful framework for psychiatrists, primary care clinicians, therapists, dietitians, and multidisciplinary teams who wish to incorporate ketogenic metabolic therapy into individualized treatment plans.If you are a clinician interested in learning more about metabolic approaches in psychiatry, we encourage you to explore the full publication.If you are a patient or family member, consider sharing this paper with your care team to start an informed discussion about whether metabolic strategies may be appropriate in your individual case.With the clinical evidence still accumulating and randomized controlled trials ongoing, we expect this clinical guidance to continue to evolve as more data and real word experience becomes available.

Polycystic Ovary Syndrome (PCOS) is the leading cause of infertility in women, but what if the real issue isn't the ovaries?In this eye-opening conversation, Dr. Bret Scher speaks with Dr. Steven Palter, reproductive endocrinologist and founder of Gold Coast IVF, about the powerful connection between PCOS, metabolic health, mental health, and fertility.For decades, PCOS has been treated symptom-by-symptom: birth control for irregular cycles, fertility drugs for ovulation, IVF for infertility. But Dr. Palter explains why this approach often misses the root cause: insulin resistance and metabolic dysfunction.When you address the metabolic driver, everything can change.Ketogenic and low-carbohydrate dietary approaches are showing promise in improving insulin sensitivity, restoring ovulation, improving mood, and even supporting fertility, often before significant weight loss occurs. In many cases, women who were preparing for IVF are conceiving naturally after correcting their metabolic health.In this video, you'll learn:Why PCOS is best understood as a metabolic disorderHow insulin resistance drives infertility, mood changes, and long-term health risksWhy traditional “eat less, move more” advice often failsHow ketogenic therapy may restore ovulation and improve fertilityThe connection between PCOS, depression, and binge eatingWhy GLP-1 medications aren't the same as metabolic repairIf you or someone you know is struggling with PCOS, infertility, or unexplained hormonal symptoms, this episode offers a hopeful and science-based perspective on what's possible when metabolic health becomes the priority.As always, consult your healthcare provider before making significant dietary changes.

The Ketogenic diet is popular for weight loss in humans, but does it work, and can it work with my grass-eating horses? The simple answer is yes, and you don't need to make them carnivores! A ketone, also known as beta-hydroxybutyrate, can be produced in two ways in horses. The first is the bacterial breakdown of cellulose in their hindgut. I have discussed this elsewhere, and it is the primary source of this ketone. The second way occurs when a horse consumes its body fat, which then forms ketones. The most common way to force a horse to consume its body fat is to starve them, and this is exactly what happens in starvation. But we don't need to go that far. What starts the horse making its own ketones is deciding to stop eating. There are two ways to do this: feed adequate amounts of high-quality protein, and stop feeding excess glucose (sugar) in the form of starch found in grains, grain mixes, balancers, supplements, treats, and excess hay. Believe it or not, but the more you feed food filled with glucose, the hungrier the horse will become. It is a paradox, but it is essential to understand if you want your horse to lose body fat, maintain muscle, become healthy, and remain sound. ********** Community.TheHorsesAdvocate.com is a place to learn about horses, barns, and farms. Its information is free, and a membership option lets horse owners attend live meetings to ask questions and deepen their understanding of what they have learned on the site. Membership helps support this message and spread it to everyone worldwide who works with horses. The Equine Practice, Inc. website discusses how and why I perform equine dentistry without immobilization or the automatic use of drugs. I only accept new clients in Florida. Click here to make an appointment. The Horsemanship Dentistry School is a place for those interested in learning how to perform equine dentistry without drugs on 97% of horses. Thank you for sharing and "Helping Horses Thrive In A Human World."

Send a textDr. David G. Harper is a returning guest on our show! Be sure to check out his first appearance on episode 319 of Boundless Body Radio!Dr. David G. Harper is a health educator and cancer researcher, and has studied the impact of diet on human health for many years. The culmination of that extensive work is the BioDiet, a ketogenic food regimen that he created in 2012. The significant weight loss and health improvements he experienced led Dr. Harper to counsel thousands of people on the BioDiet, in clinical trials and on a personal basis, with consistent, impressive results.He is the author of the bestselling book BioDiet: The Scientifically Proven, Ketogenic Way to Lose Weight and Improve Health, which has become an international best-seller, reaching as high as #18 globally for books overall on Amazon.com. Dr. Harper is an Associate Professor of Kinesiology at the University of the Fraser Valley and a Visiting Scientist at the BC Cancer Research Center, Terry Fox Laboratory.He holds a Ph.D. from the University of British Columbia and completed a post-doctoral fellowship in comparative physiology at the University of Cambridge. He was on the Scientific Advisory Board of the Canadian Clinicians for Therapeutic Nutrition and a member of the Institute for Personalized Therapeutic Nutrition. He is a great friend and a great human being!Find Dr. Harper at-https://www.biodiet.org/LK- Dr. David G. HarperFB- @Dave HarperReciprocal Meat Conference June 21-24, 2026 in Amarillo, TX!How It's Made - Canola Oil! UNBELIVABLY DISGUSTING.Check out his amazing talk at Keto Salt Lake 2022!Find Boundless Body at-myboundlessbody.comFind Boundless Body at- myboundlessbody.com Book a session with us here!

In this powerful interview, Dr. Bret Scher speaks with Dr. Robin Engelhardt, a German researcher and PhD in psychology, who is launching a pilot study investigating ketogenic metabolic therapy as a treatment for PTSD and complex PTSD.Using his own personal experience of healing from PTSD through nutritional ketosis, Dr. Engelhardt is now launching a pilot study to explore whether this approach can help others. His pilot study will test feasibility, safety, and symptom response, paving the way for future randomized controlled trials.

Can a ketogenic diet help with depression when other options have failed? Emerging suggests the answer may be yes.In this video, Dr. Bret Scher shares the latest clinical data on ketogenic therapy for depression, including two new studies showing meaningful improvements, even remission, in people with moderate to severe symptoms. For individuals struggling with treatment-resistant depression, these findings offer real hope and open the door to a new therapeutic pathway: metabolic interventions that target brain energy.In this video, you'll learn:How ketosis may support brain function and mental healthWhat two new pilot studies reveal about keto for depression and anhedoniaHow researchers are beginning to rethink the metabolic roots of mood disorders

Dr. Mary Newport shares groundbreaking research analyzing cholesterol profiles across 40 years of studies, challenging conventional wisdom about saturated fat and heart health. We discuss her findings on MCT oil for brain health, the 288 caregiver reports showing cognitive improvements, and practical protocols for using coconut oil and ketones.Dr. Mary Newport, physician and Alzheimer's researcher, joins us to discuss her latest research that challenges decades of assumptions about coconut oil and saturated fat. In this interview, we explore: • Her comprehensive analysis of 26 studies spanning 40 years (984 lipid profiles) showing coconut oil's unexpected effects on cholesterol • The 288 caregiver reports documenting improvements in memory, cognition, and daily function • How medium-chain triglycerides (MCTs) may provide an alternative fuel source for aging brains • Practical protocols for incorporating coconut oil and MCT oil into your diet • The controversial history of dietary fat guidelines and the trans fat problem • Why the medical establishment has been slow to acknowledge ketone research Dr. Newport's work began with her husband Steve's dramatic response to coconut oil after his early-onset Alzheimer's diagnosis. Her research has since expanded to include hundreds of case reports and comprehensive lipid analysis.

Send us a textBenjiman Boyd is a graduate researcher and metabolic health advocate dedicated to exploring the intersection of diet and neurometabolism.With over seven years of personal experience successfully managing ADHD and depression through a ketogenic lifestyle, he brings a unique blend of lived insight and academic rigor to the field. Currently, his thesis work investigates the potential of the ketogenic diet as a treatment for Borderline Personality Disorder.Benjiman's ultimate mission is to obtain clinical licensure and certify in Ketogenic Metabolic Therapy, with the specific goal of bringing these life-changing metabolic interventions to patients across Upstate New York.He is a good friend and co-collaborator with our friend and former podcast guest Steven T, and was recently hosted on my dear friend Robyn Dobbins' amazing podcast, KetoBiography.Find Benjiman at-TW- @benjiboyd4LK- @benjiman boydFB Group- Metabolic CollectiveBenjiman's Thesis- Ketogenic Therapy: A Metabolic Intervention for Treatment-Resistant Borderline Personality DisorderFind Boundless Body at- myboundlessbody.com Book a session with us here!

In this special Metabolic Mailbag episode, cardiologist Dr. Bret Scher steps into the hot seat to answer your most pressing questions about ketogenic therapy, heart health, and metabolic markers. Drawing directly from listener questions, this conversation tackles the confusion and concern many people face when lab results change after starting a ketogenic diet.

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On this episode of The Dr. Hyman Show, I'm rejoined by psychiatrist and Harvard professor Dr. Chris Palmer for a conversation that challenges how we've been taught to think about mental illness. For decades, psychiatry has focused on managing symptoms—often without asking what's actually driving them. We discuss a different way of understanding mental health, one that looks beyond diagnostic labels and considers how whole-body biology influences brain function, resilience, and recovery.  Watch the full conversation on YouTube or listen wherever you get your podcasts. In this conversation, we explore: • Why mental illness is rising alongside obesity, diabetes, and other chronic diseases • How whole-body biology influences mood, focus, and emotional resilience • The link between inflammation, metabolic dysfunction, and conditions like depression and bipolar disorder • How nutrition, testing, and lifestyle changes can support real recovery If mental health has ever felt close to home for you or someone you care about, this conversation is meant to offer clarity, compassion, and a place to start. This episode was recorded live at the Eudēmonia Summit, a conference exploring the future of health, longevity, and well-being. Learn more at eudemonia.net. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Timeline, BON CHARGE, Qualia, Paleovalley, Pique and Korrus. Receive 35% off a subscription at timeline.com/drhyman. Upgrade your routine. Head to boncharge.com/hyman and use code DRMARK for 15% off. Go to qualialife.com/hyman and use code HYMAN at checkout for an extra 15% off. Head to paleovalley.com and use code HYMAN20 for 20% off your first order. Secure 20% off your order plus a free starter kit at piquelife.com/hyman.Upgrade your lighting. Enjoy 15% off at korrus.com/drhyman. (0:00) Introduction to mental health crisis and guest Dr. Christopher Palmer (1:31) Eudaimonia Summit and psychiatric revolution (3:06) Traditional and systemic views on psychiatric disorders (7:23) Misconceptions and stigma surrounding mental disorders (10:15) The impact of childhood experiences on mental health (13:28) Root causes of mental illness: Inflammation and brain dysfunction (21:23) Metabolic dysfunction in mental illness (24:15) Significance of metabolism in mental health (27:47) Metabolic nutritional psychiatry and premature mortality (32:34) The mental health revolution and metabolic treatments (34:16) Ketogenic diet as a potential treatment for mental disorders (37:18) Functional and network medicine in mental health (41:13) Biomarkers and potential treatments in metabolic mental health (49:07) Ketogenic therapy and its anti-inflammatory effects (50:12) Historical and emerging paradigms in psychiatry (54:38) Integrating functional medicine into mainstream psychiatry (56:20) Addressing chronic disease in national health discussions (58:22) Closing remarks and further resources (59:02) Podcast outro and call to action

In this eye-opening episode, we explore one of the most exciting shifts in modern mental health: the discovery that mental health is deeply rooted in metabolic health. When the brain's energy supply falters, everything from mood to memory to emotional resilience can be affected — and new research is revealing how nutrition and lifestyle can restore balance. Our guest, Moira Newiss, is a BANT-registered nutritional therapist, health coach, and accredited ketogenic metabolic therapy expert who specializes in brain energy — a newly recognized root cause of many mental health challenges. Moira helps clients understand what's happening in their biology and guides them through simple, practical changes that spark real transformation. Her work is grounded in hope, clarity, and the belief that people can not only feel better but truly get their lives back on track. Together, we unpack how ketogenic diets can provide a cleaner, more efficient fuel source for the brain through ketones, helping stabilize brain energy and improve mental well-being. Moira also explains why diet is only one piece of the puzzle — and how sleep, light, movement, and stress balance each play essential roles in optimizing brain metabolism.     Want to watch this episode on YouTube? Click here. Subscribe if you'd like to catch all new episodes live and participate with our guests directly.   Want to learn more about becoming an FDN? Go to fdntraining.com/resources to get our best free workshops and mini-courses! Where to find Moira Newiss: Website: moiranewiss.co.uk Instagram: @moiranewiss YouTube: @moiranewiss  

Send us a textBronson Dant is a returning guest on our show! Be sure to check out his appearances on episode 271, 487, 687, and 828 of Boundless Body Radio!Coach Bronson Dant has been coaching and training people in health and fitness for over 13 years. In 2018 Bronson discovered how a carnivore-based diet was the secret to extreme optimization of his metabolic health and performance. Since then, he has designed specific methods to use both nutrition and fitness to radically improve the lives of hundreds of people all over the world.Bronson has numerous certifications and extensive training in health and fitness. He is a frequent guest and subject matter expert on health and fitness podcasts and YouTube channels, including his own YT channel at Coach Bronson. He is also a prolific speaker and presenter at health conventions all over the US.Bronson is the author of several books, including The Ultimate Ketogenic Fitness Book: The complete guide to optimizing Keto for a better quality of life, and his most recent book Body Confident: Unlock the secret to strength, independence, and lifelong badassery using the F2 MethodFind Bronson at-https://coachbronson.com/IG- @coach.bronsonYT- @coach.bronsonBlog- https://coachbronson.com/blog/Study- Substrate-Corrected VO₂Models for Improved Interpretation of Movement EconomyFind Boundless Body at- myboundlessbody.com Book a session with us here!

Send us a textDeep dive into how ketogenic diets and carbohydrate intake effect exercise performance, and misconceptions in sports nutrition.TOPICS DISCUSSED:Insulin as a powerful metabolic hormone: regulates nutrient storage across tissues, overriding others like glucagon to promote fat and glucose storage during abundance.Glucagon & GLP-1 roles in metabolism: Glucagon mobilizes liver glucose during scarcity; GLP-1, amplified in drugs like Ozempic, suppresses hunger but originated as a diabetes treatment.Transition to ketosis in fasting or low-carb diets: Low insulin enables fat breakdown into ketones for brain fuel, allowing survival for weeks without food, with adaptation taking about four weeks.Hypoglycemia vs. glycogen depletion: Low blood sugar causes fatigue and irritability due to brain energy deficit, while muscle glycogen levels do not directly limit performance.Ketogenic diets & exercise performance: Studies show no difference in endurance after adaptation, with some athletes performing better on low-carb due to enhanced fat oxidation.High-carb diets in athletes: In one study, about 30% developed prediabetes-like fasting glucose elevations, linked to total carb intake, despite leanness and fitness.Misconceptions in sports nutrition: Guidelines recommend 60-90g carbs/hour, but evidence shows 10g suffices to maintain blood sugar and performance, avoiding insulin spikes that impair fat use.Individual variability in diet response: Athletes vary in optimal fuel sources; it's possible to by athletic and lean but also metabolically unhealthy.PRACTICAL TAKEAWAYS:For workouts over ~60 minutes, consume ~10g carbs per hour (e.g., a third of a banana) to maintain blood sugar and prevent fatigue, regardless of overall diet.Allow at least four weeks for adaptation when trying a ketogenic diet, enabling the body to fully transition to the ketogenic state.Monitor personal responses to carb intake, as high levels can elevate fasting glucose even in fit individuals; consider lower-carb options if experiencing metabolic issues.Prioritize metabolic flexibility through varied diets or fasting periods to improve energy stability, but consult resources for proper formulation to support health.ABOUT THE GUEST: Andrew Koutnik, PhD earned a PhD in biomedical sciences with a focus on exercise physiology and metabolic health, informed by his personal diagnosis of type 1 diabetes in childhoodSupport the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Amanda King ND is a nutritional therapist, naturopathic practitioner, and author of Metabolic Drugs for Cancer (co-written with Dr. Hari Kuhan). She also writes The Metabolic Nutritionist on Substack—followed by 30,000+ subscribers—where she breaks down off-label oncology drugs, supplements, and metabolic approaches to cancer care in clear, practical language. In this episode, Dr. King joins Dr. Michael Karlfeldt to explain why “cancer is a disease of metabolism” is more than a slogan—and how understanding metabolic weaknesses can empower smarter, more personalized integrative strategies.You'll hear how repurposed medications can target cancer's metabolic pathways (glucose, mitochondria, inflammatory signaling, and more), and why personalization matters more than internet protocols. Amanda and Dr. Karlfeldt discuss the Care Oncology “METRICS” drug set (including metformin, statins, doxycycline, and mebendazole), plus additional tools like ivermectin, fenbendazole, DCA, 2-DG, anti-inflammatories (aspirin/COX pathways), histamine blockers (cimetidine), and even PDE5 inhibitors like sildenafil/tadalafil—along with real cautions around dosing, contraindications, and interactions (including potential conflicts with immunotherapy). The conversation also ties metabolic therapy to the “press–pulse” concept and terrain-based care: ketogenic nutrition, inflammation reduction, oxygenation, and lifestyle foundations that strengthen the body while making cancer more vulnerable.Whether you're a patient, caregiver, or practitioner, this episode offers a grounded roadmap for thinking about integrative oncology without guesswork—using a “test, assess, address” mindset to build a strategy that evolves with labs, symptoms, treatment phases, and the individual.Key Topics Covered (bulleted)Why cancer metabolism (not just genetics) is a key lever in integrative oncologyWhat repurposed/off-label drugs can target: glucose pathways, mitochondria, signaling pathways (e.g., EGFR/AKT/mTOR)Why one-size-fits-all protocols are risky—and how to personalize using “test, assess, address”The Care Oncology/METRICS drug set and when it may (or may not) fitSafety and dosing concerns with high-dose ivermectin/fenbendazole and DIY internet protocolsWhen metformin vs berberine may be appropriate—and why they can sometimes be combinedDoxycycline: potential synergy (e.g., with IV vitamin C) vs contraindications (including immunotherapy concerns)Anti-inflammatory strategy: COX pathways, aspirin vs selective COX-2 approaches, plus natural options“Press–pulse” metabolic strategy and why protocols should evolve over timeOther emerging tools discussed: DCA, 2-DG, cimetidine, itraconazole, PDE5 inhibitors (Viagra/Cialis) -----------------------------------------------A Better Way to Treat Cancer: A Comprehensive Guide to Understanding, Preventing and Most Effectively Treating Our Biggest Health ThreatGrab my book here: https://www.amazon.com/dp/B0CM1KKD9X?ref_=pe_3052080_397514860 Unleashing 10X Power: A Revolutionary Approach to Conquering CancerGet it here: https://store.thekarlfeldtcenter.com/products/unleashing-10x-powerPrice: $24.99100% Off Discount Code: CANCERPODCAST1 Healing Within: Unraveling the Emotional Roots of CancerGet it here: https://store.thekarlfeldtcenter.com/products/healing-withinPrice: $24.99100% Off Discount Code: CANCERPODCAST2-----------------------------------------------Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com

Is carb-cycling okay on a ketogenic diet? What about high histamine foods?In this episode of Metabolic Mailbag, Dr. Bret Scher and Dr. Georgia Ede answers questions on everything from the best sources of dietary fat to how to handle anxiety, perimenopause, and alcohol while maintaining ketosis.They unpack how to build a nutrient-dense, brain-supportive ketogenic diet using whole foods, why “keto-friendly” processed products can sometimes derail progress, and when supplements might be beneficial. You'll also learn why histamine sensitivity, caffeine, or cycling in and out of ketosis can affect mood, and how to troubleshoot each.This conversation covers:Why a whole food ketogenic diet can be ideal for mental healthHow to identify the best fat sources and avoid “factory fats”Ketogenic dieting for women's healthWhy anxiety can worsen mid-journey, and how to adaptThe truth about alcohol, carb cycling, and ketosisIf you're exploring ketogenic therapy for mental or metabolic health, this episode offers practical, science-based guidance to help you refine and personalize your approach.

Shannon Davis, a Registered Dietitian Nutritionist with more than 19 years of experience specializing in metabolic health and insulin resistance. She's a founding board member of the American Diabetes Society, an Insulin IQ Coach, and the founder of a successful virtual metabolic health practice where she's helped nearly a thousand people reverse insulin resistance, lose weight, and even put type 2 diabetes into remission. Shannon's background spans dialysis, organ transplant, bariatrics, and pharmaceutical sales — giving her a unique perspective on why food, not medication, is the real solution to most dietary conditions. She's been featured on over 50 podcasts as an expert in metabolic health, and when she's not helping people transform their lives, you'll find her in the gym doing CrossFit or spending time riding horses — her lifelong passion. Instagram: https://www.instagram.com/sldavis6580 X: https://x.com/fittoeat6580 YouTube: https://youtube.com/@shannondavis1619 Facebook: https://www.facebook.com/shannon.davis.9279 Website: https://shannonfeelgreat.com/ Timestamps: 00:00 Trailer 00:53 Introduction 05:31 Renal care challenges and ethics 09:11 Kidney health and low-carb diets 10:41 Keto and kidney care 13:44 Dialysis conflict of interest 18:39 Diabetes advocacy and carnivore 21:16 Ketogenic diets and diabetes 24:02 Preventing heart disease 28:16 Diet wars and social media 31:26 Better living through medication 34:04 Platform censorship frustrations  37:14 Grassroots health movement challenges 42:51 AI transforming pharmaceutical marketing 43:30 Drug industry priorities  49:16 Low carb diet and cholesterol 50:29 Where to find Shannon 53:43 United in the fight Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

Beth Zupec-Kania is a leading global expert in ketogenic therapy, known for her decades of clinical experience and clear, compassionate guidance. A registered and certified dietitian-nutritionist, she has spent more than 30 years helping clinicians, patients, and families use therapeutic ketosis safely and effectively for neurological, psychiatric, metabolic, and even select cancer-related conditions. In this episode, Dr. Tro, Dr. Brian, and Beth talk about… (00:00) Intro (02:23) What The Charlie Foundation is and how Beth first became involved (05:09) The frustrations Beth faced as a nutritionist promoting an, at the time, very taboo diet in the ketogenic diet (09:37) How Beth initially came to see the power of keto as a therapy for people with epilepsy (12:16) The evolution of the keto diet over the decades (18:40) How the keto diet can be life changing for children with epilepsy (27:28) Epilepsy patients weaning off of the keto diet (30:22) Why a supplemental or drug cannot replace the keto diet for epilepsy patients (32:44) How sugar and the microbiome play into epilepsy and seizure disorders (41:28) Beth's personal experience with the ketogenic diet (47:38) HRT, women's health, and the keto diet (51:54) Addiction and denial (56:55) Fatty liver disease and the keto diet (01:00:02) The new dietary guidelines (01:04:04) Eating REAL fats (01:05:52) For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Beth Zupec-Kania: The Charlie Foundation: https://charliefoundation.org/ Website: https://www.bethzupeckania.com/ Keto Mastery: https://www.ketomastery.pro/ Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

Send us a textJohn LaSpina is a returning guest on our show! Be sure to check out his appearances on episodes 575, 582, 606, 718, and 834 of Boundless Body Radio!John LaSpina is a passionate educator and advocate for the power of ancestral, animal-based nutrition. After transforming his own health through the carnivore lifestyle, John dedicated his life to teaching others the simple, profound truth: that optimal health and vitality are our natural states when we fuel our bodies properly.Through his popular YouTube channel Carnivore Teacher Alpha, John has helped thousands rediscover strength, clarity, and freedom by returning to the foods we were designed to eat.His mission is: To educate, inspire, and empower others to reclaim their lives with purpose, pride, and unstoppable power. His motto is: Eat well, so that you can look and feel well and become the optimized version of yourself!He is the author of The Carnivore Teacher: A Meat-Based Education for Total Transformation, The Carnivore Teacher Workbookand his latest book Processed To Death: The Truth About Ultra-Processed Food and How to Escape Its Grip.Find John at-YT@- Carnivore Teacher AlphaIG- @carnivoreteacherjohnLK- @Carnivore TeacherFind Boundless Body at- myboundlessbody.com Book a session with us here!

Send us a textToday we are releasing a SPECIAL EPISODE where we are doing a podcast trade with Healing with the Diamonds!Larry and Kay Lynne Diamond have experienced a profound transformation in their family's health, a journey that has significantly altered their lives. Together, they have shed a remarkable 190 pounds and successfully reversed a multitude of health issues, including sleep apnea, allergies, asthma, severe irritable bowel syndrome, psoriasis, depression, anxiety, brain fog, joint pain, and persistent fatigue.Their approach has been rooted in an ancestrally inspired way of eating and living, harmonized with modern scientific insights and a deep respect for the wisdom of nature.Larry's passion for health and wellness led him to become a Primal Certified Health Coach. He made a pivotal career change to focus on health coaching, dedicating six years to this field as a coach and researcher for The Fasting Method.Understanding the challenges that families face when trying to take control of their health, Larry and Kay Lynne established Healing with the Diamonds. Their mission is to provide support and guidance to individuals at any stage of their wellness journey, and they are committed to helping others discover what works best for themselves!Find Healing with the Diamonds at-https://www.healingwiththediamonds.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

Dr. Caroline Roberts is a board-certified physician and leading clinician at Virta Health, where she helps patients reverse type 2 diabetes through evidence-based, nutrition-focused care. Known for her compassionate approach and expertise in metabolic health, Dr. Roberts empowers individuals to reclaim their health using sustainable, real-world strategies. Her work blends cutting-edge science with practical guidance, making her a standout voice in the movement to transform diabetes care. In this episode, Drs. Tro, Brian, and Caroline talk about… (00:00) Intro (02:44) How Dr. Caroline discovered the power of keto for reversing Type 2 diabetes and controlling Type 1 diabetes (08:46) Why you don't need to eat 120 grams of carbs per day (10:36) DKA risk in Type 2 patients (18:15) Type 1 patients and low carb diets (23:36) Ketogenic diets and cardiovascular outcomes (30:44) Why the medical world has been so slow to acknowledge the benefits of keto and low carb diets (44:08) Dietary sustainablility  (45:58) CGMs, finger sticks, and keto diets (54:36) Long term patient outcomes from Virta patients (58:57) Keto and psychiatric health (01:04:08) Outro For more information, please see the links below. Thank you for listening! Links: Please consider supporting us on Patreon: https://www.lowcarbmd.com/ Dr. Caroline Roberts: Papers:  https://www.researchgate.net/profile/Caroline-Roberts-17 Virta Health: https://www.virtahealth.com Dr. Brian Lenzkes:  Website: https://arizonametabolichealth.com/ Twitter: https://twitter.com/BrianLenzkes?ref_src=twsrc^google|twcamp^serp|twgr^author Dr. Tro Kalayjian:  Website: https://www.doctortro.com/ Twitter: https://twitter.com/DoctorTro IG: https://www.instagram.com/doctortro/ Toward Health App Join a growing community of individuals who are improving their metabolic health; together.  Get started at your own pace with a self-guided curriculum developed by Dr. Tro and his care team, community chat, weekly meetings, courses, challenges, message boards and more.  Apple: https://apps.apple.com/us/app/doctor-tro/id1588693888  Google: https://play.google.com/store/apps/details?id=uk.co.disciplemedia.doctortro&hl=en_US&gl=US Learn more: https://doctortro.com/community/ 

Send us a textToday we are releasing another bonus episode! This is my recent appearance on The Low Carb Consultant Podcast, hosted by Max Helmer! We hosted Max on our show as well, on episode 887 of Boundless Body Radio!As always, it was a fun chat, and I'm always so grateful to be a guest on someone else's show!Find Max at-IG @thelowcarbconsultantPodcast- The Low Carb Consultant PodcastYT @Max Helmer The Low Carb ConsultantFind Boundless Body at- myboundlessbody.com Book a session with us here!

Send us a textLisa La Nasa is a returning guest on our show! Be sure to check out her first appearance on episode on 704 of BBR!Lisa La Nasa is a mom of two, wife, adventurer, coffee fanatic, and founder and CEO of diaVerge Diabetes. Lisa founded diaVerge Diabetes in 2015 after her own personal discovery of the empowerment and complete lifestyle transformation that can come from gaining better control of type 1 diabetes.She has successfully been maintaining A1c levels

With an animal based diet, Selina lost over 112 pounds, regained fertility, and greatly improved her thyroid related symptoms, leading to reversal of her thyroid cancer diagnosis. Instagram: @primalfoxhealth / @thecarnivorecommunityworldwide YouTube:: @primalfoxhealth Website: https://stan.store/primalfox Timestamps: 00:00 Trailer 00:35 Introduction 05:59 Fitness, strength, and misguided advice 07:19 Postpartum weight gain and fatigue 11:10 Thyroid concerns and treatment options 15:19 Healing journey through keto/animal-based eating 18:27 Thyroid mass and treatment options 23:28 From processed foods to sunlight 25:08 Vegan childhood to eating meat 31:08 Ketogenic pregnancy and barbecue 34:17 Diet transition and perspective 37:40 Realizing hidden pain through diet 40:07 Where to find Selina Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs ‪#Revero #ReveroHealth #shawnbaker  #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.

David Baszucki is the founder and CEO of Roblox. TIME named Roblox one of the “100 Most Influential Companies,” and it has been recognized by Fast Company for innovation on their “Most Innovative Companies” and “Most Innovative Companies in Gaming” lists.This episode is brought to you by:Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/TimAG1 all-in-one nutritional supplement: https://DrinkAG1.com/TimWealthfront high-yield cash account: https://Wealthfront.com/TimNew clients get 3.75% base APY from program banks + additional 0.65% boost for 3 months on your uninvested cash (max $150k balance. Terms apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 9/26/25 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB. Experiences will vary. Outcomes not guaranteed. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, bank-guaranteed or FDIC-insured, and may lose value.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

NEW! Support your strength and muscle goals with PUORI Creatine+ — a clean, effective creatine monohydrate supplement enhanced with taurine. Get 20% off at puori.com/VANESSA In this masterclass episode, Vanessa sits down with Dr. David Church, one of the most exciting young researchers in protein metabolism and a mentee of Dr. Arny Ferrando and Dr. Robert Wolfe. Together, they break down the latest science on protein timing, distribution, and supplementation — and how to apply it to achieve fat loss, preserve muscle, and enhance cognition. You'll learn: • How stable isotope tracer studies work and what they reveal about muscle protein synthesis (MPS). • The minimum protein per meal needed to trigger muscle growth and repair — and whether you can hit it with two meals a day. • The truth about intermittent fasting and muscle preservation — what happens to MPS in 2-meal and 1-meal-a-day patterns. • Why older adults and women over 40 face anabolic resistance and how EAAs (essential amino acids) can help overcome it. • What happens when you double your protein intake from 0.8 g/kg to 1.6 g/kg — and why distribution may matter less than total intake. • The surprising power of small doses of EAAs in muscle maintenance and cognitive support. • Why creatine is foundational for women, including new research showing benefits for brain health and sleep deprivation. • How to optimize body recomposition — burning fat while protecting lean mass — even during calorie restriction. • The difference between supplemental vs. replacement nutrition, and why EAAs work for older adults with low appetite. • The synergy of protein + resistance training + sleep + activity in driving sustainable fat loss. OneSkin is powered by the breakthrough peptide OS-01, the first ingredient proven to reduce skin's biological age. I use the OS-01 Face and Eye formulas daily—they've transformed my skin's smoothness, firmness, and glow. Visit oneskin.co/VANESSA and use code VANESSA for 15% off your first purchase Dr. Church also shares his own daily stack — including why he takes 20 g of creatine per day and combines it with EAAs for energy, cognition, and recovery — plus his favorite high-protein meals for busy days. If you've ever wondered how to burn fat efficiently while protecting every gram of muscle, this episode is packed with evidence-based takeaways you can implement right away. Mentioned in this Episode: • Puori Creatine + – clean, third-party-tested creatine monohydrate with taurine • Essential amino acids for older adults and women facing anabolic resistance • Stable isotope tracer studies — how we truly measure MPS • Protein targets: 1.6–2.4 g/kg depending on activity and energy restriction • Pre-sleep protein and its impact on overnight MPS and metabolic rate Get delicious high protein meal recipes! Connect with Vanessa on Instagram @ketogenicgirl Free High-Protein Keto Guide  Get 20% off on the Tone LUX Crystal Red Light Therapy Mask or the Tone Device breath ketone analyzer at https://ketogenicgirl.com with the code VANESSA Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the Facebook group for the podcast The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Beat BLOAT & unlock better protein absorption and digestion with MassZymes by BiOptimizers. NOW GET 15% off your order with the code VANESSA at bioptimizers.com/vanessa What separates people who keep fat off from those who regain it? In this episode, Vanessa Spina breaks down the latest research on long-term fat loss maintenance — including insights from one of the world's most respected obesity and metabolism researchers, Dr. James Hill. You'll learn the proven strategies that help preserve lean muscle, protect metabolism, and create sustainable fat loss — all backed by decades of science. Vanessa unpacks Dr. Hill's three-bucket model for lasting success, showing how to combine nutrition, activity, and mindset into a lifelong blueprint for body recomposition and metabolic health. Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa In this episode, you'll discover: • Why losing fat and keeping it off require two completely different skill sets • The research-backed protein and training strategies that preserve lean muscle • How small daily changes — like 100 fewer calories or 2,000 more steps — compound over time • Why exercise “fixes” your metabolism and helps you stay lean for life • The concept of your appetite sweet spot — and how to find it • How to shift from a “victim” to “voyager” mindset and make maintenance effortless • Dr. Hill's insights on GLP-1 medications and how to transition off without regaining weight If you've ever lost weight and struggled to maintain it, this episode will show you the science of what truly works — and how to protect your lean mass, metabolism, and confidence for the long term. Get my free NEW high-protein keto guide: The Keto Reset eBook Learn more about the TONE LUX Crystal red light therapy mask and the accessory the TONE LUX CONTOUR for the neck and décolleté and get 20% OFF with the code VANESSA Free high-protein keto guide: The Keto Reset eBook

Dr. Dominic D'Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by: Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)Timestamps:[00:00:00] Start.[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.[00:18:18] A mechanisms overview for Alzheimer's/dementia.[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.[00:22:04] How to measure ketones and GKI.[00:23:00] Fasting vs. ketogenic diet.[00:24:18] There's nothing fishy about sardine fasting.[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.[00:31:57] Glucose tolerance testing revelations and CGM importance.[00:31:57] Upgrading the metabolic machinery through keto without getting bored.[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.[00:43:42] Dom's day-to-day diet regimen.[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.[00:51:30] Supplementing for sleep disruption while fasting.[00:55:41] Why Dom doesn't have misgivings about melatonin.[00:59:15] Shingles prevention through fasting protocols.[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.[01:03:54] Dom at 50-something: Current meal timing and composition.[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.[01:15:18] Ketone metabolic therapy for cancer.[01:18:15] The metabolic psychiatry revolution.[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.[01:28:27] Metformin vs. berberine.[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.*Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim's email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim's books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.