Podcasts about Molecular Pharmacology

Jennifer Garrison, PhD, is Co-Founder and Director of the Global Consortium for Reproductive Longevity and Equality (GCRLE) and an Assistant Professor at the Buck Institute for Research on Aging. She also holds appointments in the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF) and the Leonard Davis School of Gerontology at the University of Southern California (USC). She is a passionate advocate for women's health and is pioneering a new movement to advance science that is focused on female reproductive aging. Her lab studies the role of mind-body communication in systemic aging, and how changes in the conversation between the ovary and brain during aging may lead to the onset of reproductive decline in females.About Foresight InstituteForesight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison DuettmannThe President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".Get Involved with Foresight:Apply to our virtual technical seminars Join our in-person events and workshops Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!Follow Us: Twitter | Facebook | LinkedInNote: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine. Hosted on Acast. See acast.com/privacy for more information.

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at www.nuzest.co.nz, www.nuzest.com.au or www.nuzest.comToday on the podcast, Mikki speaks to Dr. Dom D'Agostino, a leading researcher in metabolic health, ketogenic diets, and performance optimization. Dom has been at the forefront of exploring how nutrition—particularly low-carb and ketogenic strategies—impacts brain health, endurance performance, cancer metabolism, and longevity.In this episode, he and Mikki dive into two major topics that have been gaining traction in the health and nutrition space: allulose as a metabolic sweetener and the latest research on the ketogenic diet's effects on lipids, gut health, and glucose metabolism.They begin by unpacking allulose, a rare sugar that's rapidly growing in popularity within the low-carb and metabolic health community. Dom has conducted extensive n=1 experiments on this sweetener and has shared his insights widely on social media. He explains how allulose differs from traditional sweeteners, its impact on blood sugar, insulin, and GLP-1, and whether it could be a game-changer for metabolic health. They also discuss how the FDA's labeling decision influences consumer perception and what role allulose might play in future dietary strategies.The conversation then shifts to the ketogenic diet, exploring a recent study that examined its effects on metabolic health, gut microbiome, and cardiovascular markers. Some of the findings—such as increased ApoB and transient inflammation—have sparked debate, and Dom provides his perspective on what these results actually mean. He and Mikki also discuss the implications of gut microbiome shifts, the potential concerns around glucose tolerance, and how to fine-tune a ketogenic approach for long-term health.For anyone interested in the cutting edge of metabolic science—whether it's the role of emerging sweeteners or the nuances of ketogenic diets—this episode is packed with valuable insights.Dr. Dominic D'Agostino is a leading researcher in the fields of metabolic health, ketogenic nutrition, and performance science. As an Associate Professor at the University of South Florida in the Department of Molecular Pharmacology and Physiology, his work focuses on the neuroprotective and therapeutic applications of ketogenic diets, exogenous ketones, and metabolic therapies for conditions such as epilepsy, cancer, and neurodegenerative diseases.Dr. D'Agostino's research spans human performance, space medicine, and metabolic resilience, with collaborations extending to NASA, the Department of Defense, and leading medical institutions. His work has explored how ketogenic and fasting-based strategies can enhance physical and cognitive function under extreme conditions, from deep-sea diving to spaceflight.In addition to his academic and research work, he is widely recognized for his expertise in low-carb and ketogenic science, frequently sharing insights on his podcast appearances, social media, and public talks. He has conducted extensive n=1 experiments on metabolic biomarkers, dietary interventions, and the effects of ketones and alternative sweeteners like allulose, helping to bridge the gap between scientific research and real-world application.Dr. D'Agostino is also on the editorial board of multiple scientific journals, has published extensively in peer-reviewed literature, and is a sought-after speaker in the areas of metabolic health, longevity, and human optimization. His work continues to push the boundaries of what's possible in nutrition science and metabolic therapiesMetabolic link https://podcasts.apple.com/au/podcast/the-metabolic-link/id1666125722Metabolic Health Summit https://metabolichealthsummit.com/Dom's website https://www.drdominicdagostino.com/Ketogenic diet and gut health https://www.sciencedirect.com/science/article/pii/S2666379124003811?via%3Dihub  Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to www.curranz.co.nz  or www.curranz.co.uk to order yours Contact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwilliden

The Promise of Discovery Season 5, Episode 3 Neurofibromatosis Type 1 (NF1) is a neurodevelopmental disease which affects about 100,000 people in the US. Around 80% of these patients experience cognitive and intellectual impairments which are unaffected by currently approved therapies for NF1. A recent genetic study from our lab identified an association between the NF1 disease and a receptor protein called metabotropic glutamate receptor 7 (mGlu7). This project investigates how using small molecules to augment mGlu7 function could help identify new therapies for NF1 patients struggling with cognitive impairments. Featuring: Harrison Parent, Ph.D. Candidate- Niswender Lab, Department of Pharmacology, Vanderbilt University School of Medicine Interviewer: Colleen Niswender, Ph.D., Associate Professor of Pharmacology; Director of Molecular Pharmacology, Warren Center for Neuroscience Drug Discovery, and a Vanderbilt Kennedy Center Member

Dr. Keith Ellis is a Scientist and Associate Professor of Medicinal Chemistry that is dedicating his time, energy, and talents to helping people recover from Long Covid. Dr. Ellis is using his knowledge, expertise, and experience in medicinal chemistry, pharmacology, and natural products to research the biological mechanisms that cause Long Covid and the potential therapeutic mechanisms that can help people recover. Combining this scientific work with his interest in entrepreneurship, Dr. Ellis has designed and brought to market a custom-formulated natural product supplement to help people recover from Long Covid. In 2023, Dr. Ellis founded Science-Driven Supplements and launched its first product: CircuGuard - a natural, herbal supplement to help people recover from Long Covid microclots. Dr. Ellis and Science-Driven Supplements are committed to creating custom-formulated solutions for people with Long Covid that are safe, inexpensive, accessible for everyone without a doctor's prescription, and available RIGHT NOW. Several more products targeting other underlying biological mechanisms of Long Covid are in the design phase and will be launched in the coming year. In parallel with his Long Covid research and work as Founder of Science-Driven Supplements, Dr. Ellis serves as an Associate Professor of Medicinal Chemistry conducting academic research in early lead discovery in the oncology field and teaching organic and medicinal chemistry to graduate students, professional students, and undergraduates. Dr. Ellis has published academic scholarly work in world-class scientific journals including: the Journal of Natural Products, ACS Medicinal Chemistry Letters, ACS Chemical Biology, Molecular Pharmacology, Oncotarget, Oncogene, Bioorganic & Medicinal Chemistry, and Cancer Biology & Therapy. Career Highlights: Founder - Science-Driven Supplements, LLC - 2023 Faculty PositionsVirginia Commonwealth University, Richmond, VAAssociate Professor of Medicinal Chemistry (with Tenure) - 2018-presentAssistant Professor of Medicinal Chemistry - 2008-2018 Education and Professional TrainingBA Cum Laude (Chemistry) - 1999 - Cornell University, Ithaca, NYPhD (Chemistry) - 2004 - University of Virginia, Charlottesville, VAPost-Doctoral Researcher - 2005-2006 - Department of Medicinal Chemistry, University of Kansas, Lawrence, KSResearch Associate - 2007-2008 - Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN Long Covid Research, Social Media Links, and LinkedIn Profile can be found at www.keithcellisphd.com.

Dr. Craig Svensson is a Dean Emeritus of Pharmacy and Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue University, as well as an Adjunct Professor of Pharmacology and Toxicology at the Indiana University School of Medicine. He is also an elected Fellow of the American Association for the Advancement of Science and the American Association of Pharmaceutical Scientists. He's the authored over a hundred scientific publications and several books, including When the Hurt Won't Heal and the mini-book, Recreational Drug Use: A Biblical Perspective. He lives in West Lafayette, IN, and he's been married to his beautiful bride for 40 years.  To find out more about Dr. Craig, you can visit his website: http://www.craigsvensson.com or email him at svensson@purdue.edu . ------------------------------------------------   If you want to help us transform the lives of even MORE MEN for God's glory, please take a minute to leave us a helpful REVIEW on iTunes: http://www.rmcpodcast.com and SHARE this podcast with any young man (or men) you're mentoring or discipling. And make sure you don't miss an interview episode by signing up for our Man-to-Man eNewsletter at http://www.RealMenConnect.com, and grab your FREE copy of the Real Men Victory Tracker.    Talk with Dr. Joe 1-on-1: Are you stuck? Want to go to get your faith, marriage, family, career and finances back on track?  Then maybe it's time you got a coach. Every CHAMPION has one. Schedule an appointment to chat with Dr. Joe on how we can help you spiritually love and lead your family better and become the hero of your home.   Dr. Joe takes on only a few Breakthrough Calls each week to help you with your faith, marriage, work, and financial challenges.  The call is FREE, but slots are limited to ONE call only.  NO RESCHEDULES.  Just click on the link below and select the BREAKTHROUGH CALL option to set up an appointment: http://TalkwithDrJoe.com  If no slots are available, please check back in a week.   Also join us on: Join the Real Men 300: http://www.RealMen300.com Facebook Group: http://www.realmenuniversity.com/ YouTube: http://www.RealMenTraining.com Facebook: @realdrjoemartin Instagram: @realdrjoemartin Twitter: @professormartin

In this episode, we're taking a closer look at ketosis and how the ketogenic diet has evolved beyond just a weight-loss tool. I'm joined by Dr. Dominic D'Agostino, who unpacks the science behind Ketone Metabolic Therapy (KMT) and its growing role in treating conditions like epilepsy, neurological issues, and metabolic disorders. His research sheds light on the therapeutic potential of ketones, which are not only vital for energy but also key players in reducing inflammation and enhancing brain health. We also clear up some common misconceptions about keto, like battling the keto flu, and talk about practical ways to adopt and optimize the diet for better overall health. Whether you're curious about using keto for disease management or just want to understand how it can support mental and physical wellness, this episode has something for you. It's all about understanding the science and making the keto lifestyle work for your body! Key Takeaways: The ketogenic diet historically originated as a treatment for epilepsy and has expanded to other therapeutic areas, such as metabolic syndrome and neurodegenerative diseases. Ketone bodies, especially beta-hydroxybutyrate, perform dual roles as potent energy sources and cell signaling molecules that offer anti-inflammatory benefits. Keto metabolic therapy (KMT) encompasses multiple approaches, including diet, fasting, and supplements, to maintain therapeutic ketosis. Adoption of a ketogenic lifestyle may require supplement support, particularly with electrolytes, to avoid side effects like keto flu. Variations in genetic and gender responses can influence the effectiveness and experience of ketosis, necessitating personalized dietary adjustments.   More of  Dr. Dominic D'Agostino: Dr. Dominic D'Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida (USF) Morsani College of Medicine and serves as a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). He earned his B.S. in Nutritional Science and Biological Sciences from Rutgers University in 1998, followed by a Predoctoral Fellowship in Neuroscience and Physiology at Rutgers and the University of Medicine and Dentistry of New Jersey (UMDNJ) in 1999. In 2004, he completed a postdoctoral fellowship in Neuroscience at the Boonshoft School of Medicine at Wright State University in Ohio before joining USF in 2006. In addition to his teaching responsibilities, Dr. D'Agostino leads a lab focused on developing and testing nutritional strategies and metabolic-based therapies for neurological disorders, cancer, and metabolic optimization. His research includes both basic science studies and human clinical trials. He has a personal interest in environmental medicine and developing methods to enhance the safety and physiological resilience of military personnel and astronauts in extreme environments. Dr. D'Agostino's research in metabolic control and neuroscience is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations, and nonprofit foundations. Website Instagram Facebook Connect with me!: Website Instagram Facebook YouTube

Michele Pagano, Chairman of the Department of Biochemistry and Molecular Pharmacology at NYU School of Medicine, takes us through his groundbreaking research on the Ubiquitin-Proteasome System and Cullin-RING Ligases. As a leading Investigator at the Howard Hughes Medical Institute, Professor Pagano shares insights into targeted protein degradation and its potential for treating “undruggable” cancer proteins. Reflecting on the evolving dynamics within academia, he discusses the challenges and intricacies of managing a research lab and offers his perspectives on the current publishing and peer review systems in scientific journals. Don't miss this engaging conversation on the challenges and opportunities shaping the future of biomedical science. Link to the paper mentioned in the show: https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2742

Send us a textDr. Luba Perry, Ph.D. is Co-Founder and CEO of ReConstruct Bio ( https://wyss.harvard.edu/technology/reconstruct/ ), an innovative venture emerging from Harvard's Wyss Institute ( https://wyss.harvard.edu/team/advanced-technology-team/luba-perry/ ), aimed at redefining the fields of medical reconstruction and aesthetics with an initial application of their groundbreaking technology on breast reconstruction and augmentation. With a multidisciplinary team of experts, the ReConstruct Bio team has developed the BioImplant—a living, bioengineered tissue created from the patient's own cells, to provide safer, more natural alternative to current standards, which are often associated with significant drawbacks and health concerns.Dr. Perry also serves as a Senior Scientist at the Wyss Institute for Biologically Inspired Engineering working at the 3D Organ Engineering Initiative since 2018 and is leading a Wyss Validation Project aiming to fabricate vascularized functional tissues for transplantation. Her interest is in tissue and organ engineering, focusing on vascularization and implantation studies utilizing complex surgical models. Dr. Perry's background is in molecular biology, pharmacology, and biomedical engineering, with a Bachelor of Science - BS, Biology, Master of Science - MS, Molecular Pharmacology, and a Doctor of Philosophy - PhD, Biotechnology, all from Technion - Israel Institute of Technology.  She also has industry experience in a vascular gene therapy company (MGVS, now VESSL Therapeutics).#LubaPerry #Harvard #WyssInstitute #ReConstructBio #Aesthetics #3DOrganEngineering #BreastReconstruction #BreastAugmentation #Vascularization #Innervation #Fat #AdiposeTissue #BreastImplants #Organogenesis #OrganEngineering #TissueEngineering #Bioengineering #Organs #Tissues #MolecularPharmacology #Breasts #Nipples#ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast  #STEM #Innovation #Technology #Science #ResearchSupport the show

Dr. Dominic D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops & tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer and wound healing. Dr. D'Agostino is one of the world's foremost experts on the ketogenic diet & metabolic health. Dr. D'Agostino has personally practiced the ketogenic diet for over a decade. His personal experiences along with his years of human and animal research, had led him to be one of the most respected voices & researchers in health & nutrition, and has been interviewed on some of the biggest shows that discuss health and nutrition like the Joe Rogan Experience.DR. DOMINIC D'AGOSTINO:WEBSITE: https://ketonutrition.org/X: https://x.com/DominicDAgosti2INSTAGRAM: https://www.instagram.com/dominic.dagostino.kt/LinkTree: https://linktr.ee/DomdagostinoTED TALK: https://youtu.be/3fM9o72ykww?si=gzBiQSBXf78TWXIPTHE RIPPLE EFFECT PODCAST:WEBSITE: http://TheRippleEffectPodcast.comSUPPORT:PATREON: https://www.patreon.com/TheRippleEffectPodcastPayPal: https://www.PayPal.com/paypalme/RvTheory6VENMO: https://venmo.com/code?user_id=3625073915201071418&created=1663262894Send BitCoin:  bc1qh0w0xyud67gvexwenh9fszzqy0np799h9qffyqSend Ethereum: 0xfeda6Da1EE8Aa06E0d63272c886277153C1ef34dMERCH Store: http://www.TheRippleEffectPodcastMerch.comMUSIC: https://music.apple.com/us/album/the-ripple-effect-ep/1057436436SPONSORS:LMNT Electrolyte Drink Mix (Free Gift With Purchase): http://DrinkLMNT.com/TheRippleEffectTHE UNIVERSITY OF REASON (Autonomy Course): https://www.universityofreason.com/a/29887/ouiRXFoLWATCH:RUMBLE: https://rumble.com/c/c-745495YOUTUBE: https://www.youtube.com/channel/UCVfy9MXhb5EIciYRIO9cKUwLISTEN:SPOTIFY: https://open.spotify.com/show/4lpFhHI6CqdZKW0QDyOicJiTUNES: http://apple.co/1xjWmlFCONNECT:TeleGram: https://t.me/TREpodcastTWITTER: https://twitter.com/RvTheory6TikTok: https://www.tiktok.com/@ricky.varandasTHE UNION OF THE UNWANTED: https://linktr.ee/TheUnionOfTheUnwanted

The ketogenic diet has surged in popularity over the last few years. According to data from the Food Information Council, 23 million Americans chose to follow a ketogenic diet in 2022, which is more than double the number from just 4 years prior (10 million in 2018). With this surge in popularity, however, comes a surge in criticism along with the adulteration of the original therapeutic principles that inevitably accompany a diet's commercialization. It's time to clear through the confusion and get to what the research is showing us. In this episode of the RWS Clinician's Corner we are joined by one of the world's topmost experts in the ketogenic diet: Dr. Dominic D'Agostino. In this interview, we do a deep dive into what every nutrition professional needs to know about the ketogenic diet: When this diet is best used clinically; when it's contraindicated; and how to structure it for best results. What the latest research is telling us about the therapeutic application of this protocol - from metabolic health to neurological considerations and cancer Exogenous ketones: when and how to use them. The intricacies of macronutrient ratios and when/how to cycle in and out of ketosis Measurement: the best forms for tracking ketosis and other key biomarkers to monitor.   Get your FREE PASS to our Clinical Success Showcase here   If you're not familiar with Dr. D'Agostino's work, you're in for a real treat. Dr. D'Agostino is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications. Join Dr. D'Agostino at the Metabolic Health Summit: https://metabolichealthsummit.com/ Learn more about the ketogenic diet here: https://ketonutrition.org/ Connect with Dr. D'Agostino on socials: Twitter: https://twitter.com/DominicDAgosti2 Instagram: https://www.instagram.com/dominic.dagostino.kt/ LinkedIn: https://www.linkedin.com/in/dominic-d-agostino-156014b/ All RWS alumni are invited to join our RWS Clinician's Corner live, meaning you get exclusive access to thought leaders on the latest research, products, tools, and best practices to get your clients exceptional results - and, ask them your very own questions. Pretty awesome, right? Learn more about becoming a Restorative Wellness Practitioner and taking advantage of this alumni benefit here: https://restorativewellnesssolutions.com Disclaimer The views expressed in the RWS Clinician's Corner series are those of the individual speakers and interviewees and do not necessarily reflect the views of Restorative Wellness Solutions, LLC. Restorative Wellness Solutions, LLC does not specifically endorse or approve of any of the information or opinions expressed in the RWS Clinician's Corner series. The information and opinions expressed in the RWS Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. Restorative Wellness Solutions, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the RWS Clinician's Corner series. By viewing or listening to this information, you agree to hold Restorative Wellness Solutions, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation.  

About the guest: Christoffer Clemmensen, PhD is scientist running the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders.Episode summary: Nick and Dr. Clemmensen discuss: GLP-1 & gut hormones; obesity & metabolic disease; GLP-1 agonists and weight loss drugs (e.g. Ozempic); novel, dual-action weight loss drugs his lab has created; and more.Previous discussion: Metabolism, Obesity & Psychedelics for Metabolic Disease | Christoffer Clemmensen | #105*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for $50 off.Learn all the ways you can support my efforts

I am honored to connect with Dr. Dave Diamond today. Dr. Diamond is a professor at the University of South Florida in their Department of Psychology, Molecular Pharmacology, and Physiology. He has a Ph.D. in biology, specializing in behavioral neuroscience. In our discussion today, Dr. Diamond talks about his journey as a neuroscientist and his interest in heart disease, and we discuss how Ancel Keys, the nutritional department at Harvard, and governmental dietary guidelines have significantly hindered our state of health. We explore the diet-heart hypothesis, the effects of seed oils and low-fat diets, the misconceptions surrounding cholesterol, metabolic errors, and the role of insulin resistance in coronary artery disease and metabolic health. We also scrutinize the implications of scientific misconduct, the effects of statins, and the role of nutrition in shaping lipid panels.  Join us for today's valuable, insightful, and informative conversation with Dr. Dave Diamond.  IN THIS EPISODE YOU WILL LEARN: How Dr. Diamond became a leading voice in heart disease research The negative impact of a low-fat, high-carb diet  How the American Heart Association ignored the effects of sugar on heart disease How seed oils have contributed to the obesity epidemic  Why a low-carb diet could increase the risk of heart disease How the demonization of cholesterol deflects from nutritional factors exacerbating poor metabolic health How the benefits of statins get overstated  How statins can lead to strokes and heart attacks and contribute to metabolic damage The perils of scientific misconduct and the profit-driven pharmaceutical industry The benefits of a low-carb diet Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. David Diamond On X (Twitter)   Email Dr. Diamond: ddiamond@usf.edu

Dominic (Dom) D'Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida. He is also a Research Scientist at the Institute for Human and Machine Cognition. YouTube: https://www.youtube.com/@jakenewfield Spotify: https://open.spotify.com/show/4k9DDGJz02ibpUpervM5EY Apple Podcasts: https://podcasts.apple.com/us/podcast/for-the-sake-of-argument/id1567749546 Twitter: https://twitter.com/JakeNewfield --- Support this podcast: https://podcasters.spotify.com/pod/show/jake-newfield/support

This episode is brought to you by Cozy Earth, Maui Nui, and Lumebox. We've heard about Dr. Thomas Seyfried's groundbreaking research and approach to cancer as a disease of metabolic dysfunction. Today's guest was inspired by Dr. Seyfried's metabolic approach and conducted his own research on brain cancer cells using ketone-based metabolic therapy and hyperbaric oxygen. His findings were mind-blowing! Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Dominic D'Agostino to discuss his extensive research on brain cancer cells placed in ketosis and under the pressure of hyperbaric oxygen. Dr. D'Agostino shares why his findings provide further insight into the idea that cancer cell growth can be metabolically managed. He also discusses how exercise and a low-carbohydrate diet can be used as metabolic therapies to reduce cancer risk. Dr. D'Agostino shares the critical tests we should focus on to assess our metabolic health and the essential supplements that can support ketosis.  Dr. Dominic D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology, where he develops and tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer, and wound healing. While studying the effects of gasses on the brains of Navy Seal divers, he developed an approach for metabolically starving cancer cells through diet and compressed oxygen, replacing chemotherapy, surgery, or radiation.   In this episode, Dhru and Dr. D'Agostino dive into (audio version / Apple Subscriber version): The most innovative approaches to cancer (00:00:11 / 00:00:11)  The metabolic approach to cancer (1:30/1:30) Using the hyperbaric approach in cancer patients (13:00/ 9:03) The results of Dr. A'gostino's studies on mice (17:00 / 13:50) How this research translates to patients (22:00 / 18:05) Why a ketogenic diet can be therapeutic (37:00 / 32:04) The role of exercise in cancer prevention (53:00 / 46:35) What lifestyle factors should we be doubling down on for prevention (55:00 / 50:14) Dr. D'Agostino's thoughts on a low carbohydrate diet (1:01:00 / 56:30) The therapeutic benefits of ketosis (1:11:00 / 1:06:40) Supplements that can support ketosis (1:19:00 / 1:12:43) How to measure for ketosis (1:24:00 / 1:18:30) Checking the status of your metabolic health (1:26:00 / 1:21:30) Where to find community (1:34:00 / 1:28:16) Also mentioned in this episode: Keto Start Donate to the University of Florida (Metabolic Therapy and Cancer Research #250244) Levels  To learn more about Dr. D'Agostino, follow him on Instagram, Twitter, or his website.  Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DHRUP. Right now, Maui Nui Venison is offering my community 20% off your first purchase. Just go to mauinuivenison.com/DHRU or enter the code D-H-R-U at check out to get 20% off and up your high-quality protein today. Lumebox is offering my community $260 off their FDA-approved portable Red Light device! That's over 40% off! Go to thelumebox.com/dhru and get your Red Light device. 

The Promise of Discovery Season 4, Episode 4 This research examines mGlu7, a transmembrane receptor involved in several neurodevelopmental disorders, such as Rett syndrome, ADHD, schizophrenia, and Neurofibromatosis Type 1. The project discussed studies the mechanism of mGlu7 activation by allosteric modulators to develop new treatments and help guide drug discovery efforts. Featuring: Xia Lei, Ph.D., postdoctoral fellow, Vanderbilt University Interviewer: Colleen Niswender, Ph.D., associate professor of Pharmacology; Director of Molecular Pharmacology, Warren Center for Neuroscience Drug Discovery; and a Vanderbilt Kennedy Center Member

Kevan M. Shokat is Professor in the Department of Cellular and Molecular Pharmacology at the University of California San Francisco (UCSF), Professor in the Department of Chemistry at the University of California Berkeley (UCB), and an Investigator with the Howard Hughes Medical Institute (HHMI). In this episode of Back of the Napkin reveals the pivotal moments and influences that have shaped his career as an academic and an entrepreneur.The conversation takes us from Kevan's early interest in chemistry, spurred by his childhood experiences in his parents' print shop, to the present day, where his laboratory at UCSF is pushing the boundaries of what was once deemed impossible in targeting key oncogenes. Listeners will discover the compelling story of a scientist whose relentless quest has been to break down fantastical goals into attainable, logical steps. This episode not only captures Kevan's intellectual odyssey but also underscores the power of interdisciplinary thinking and steadfast perseverance in unraveling nature's deepest mysteries.Follow Kevan: @kevansfFollow Alex: @MoloneyAlex

Unlock the secrets of the ketogenic diet with Dr. Dominic D'Agostino as we navigate the nuances of ketogenic protocols, from their clinical roots in epilepsy treatment to their modern-day applications in enhancing athletic prowess and brain health. Whether you're a seasoned keto aficionado or simply curious about this high-fat lifestyle, you're in for a wealth of knowledge that could reshape your understanding of nutrition.Timeline (Episode 64)1:50 Dr. Dom has cows and gators in his backyard! His dogs have fought with gators. The mammals win! 3:45 Definition of Ketogenic Diet (KD)8:18 There are over 100 years of clinical use of the KD9:04 Fasting was a “cure” for seizures11:00 Effects on the brain – how does the KD affect normal healthy subjects15:10 Dom has been a KD for 15 years18:34 Dom used the old MET-Rx brand way back when!21:00 Exogenous ketone ester supplementation studies – where do we stand on this?21:58 Consume MCT oil (the poor man's ketone ester)26:30 Higher ketone levels is not better27:00 Ketone esters > Ketone salts in extreme environments28:00 Dosing of Ketone esters (higher is not better)29:22 Don't exceed 10 grams of Beta-hydroxybutyrate34:07 Advantage of being in ketosis vis a vis performance – under conditions of glycogen depletion esp. in the cognitive domain41:57 A good supplement to start with are MCT oils (since it will elevate your ketones)45:20 Perhaps use these esters as a training aid; given acute may enhance PVT49:30 Debunking the myth that high fat diets are always “bad.”About our guest: Dominic D'AgostinoPh.D., Physiology, Neuroscience, University of Medicine and Dentistry of New Jersey, 2004B.S., Biological Sciences, Nutrition Science, Rutgers University, 1998A researcher and professor with a diverse background in neuroscience, molecular pharmacology, nutrition, and physiology, Dominic D'Agostino, Ph.D., is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida (USF) Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. D'Agostino earned his Ph.D. in 2004 and subsequently entered into a postdoctoral fellowship in neuroscience at the Boonshoft School of Medicine at Wright State University in Ohio.He has been awarded numerous grants that have resulted in national and international research collaborations and publications in such peer-reviewed journals as the Journal of Applied Physiology, Cell Metabolism, Neuroscience, Carcinogenesis, Nature Medicine, Journal of Neurophysiology, and the Journal of Microscopy.About the ShowWe cover all things related to sports science, nutrition, and performance. The Sports Science Dudes represent the opinions of the hosts and guests and are not the official opinions of the International Society of Sports Nutrition (ISSN), the Society for Sports Neuroscience, or Nova Southeastern University. The advice provided on this show should not be construed as medical advice and is purely an educational forum.Hosted by Jose Antonio, PhDDr. Antonio is the co-founder and CEO of the International Society of Sports Nutrition and the co-founder of the Society for Sports Neuroscience, www.issn.net. Dr. Antonio has over 120 peer-reviewed publications and 16 books. He is a Professor at Nova Southeastern University, Davie, Florida in the Department of Health and Human Performance.Twitter: @JoseAntonioPhDInstagram: the_issn and supphdCo-host Anthony Ricci EdDDr Ricci is an expert on Fight Sports and is currently an Assistant Professor at Nova Southeastern University in Davie Florida in the Department of Health and Human Performance.Instagram: sportpsy_sci_d

Dominic D'Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors related to ketone research. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, and neuroscience. The primary focus of his work is the human state of ketosis, ketogenesis, and developing and testing metabolic-based therapies, including dietary therapies, nutritional supplements and a variety of metabolic-based drugs. In this episode, we explore the benefits of the ketogenic diet and consuming exogenous ketones.  We unravel how ketogenic diets can not only reduce inflammation and prevent seizures, but also potentially showcase anti-cancer effects, and the fascinating role of metabolic physiology in tweaking gene expression for optimum health. We also address the potential of exogenous ketones in ramping up athletic performance and the crucial role of continuous glucose monitors. We dive into the intriguing synergy between ketogenic diets and cancer treatments, the impact of ketogenic diets on metabolism, and fat oxidation. This episode is truly a must-listen for fitness enthusiasts, ketogenic diet followers, and anyone interested in the burgeoning field of nutrition and biology.Find Dom at-https://ketonutrition.org/Blog- https://ketonutrition.org/blog-2-2/Podcast- The Metabolic Link | Podcast on SpotifyMetabolic Health Summit 2024!https://www.metabolicinitiative.com/TW- @DominicDAgosti2https://www.audaciousnutrition.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

Welcome to another episode of Superhumanize, the podcast that dives deep into the realms of health, wellness, and longevity. I'm your host, Ariane Sommer, and today we are journeying into the microscopic landscape of our biology, specifically zeroing in on the secrets of female reproductive aging. This episode is not just for women, but for anyone interested in the complex dance between aging and vitality, and how the body's smallest components can have grand ramifications on our overall well-being.My guest is an illustrious figure in the field of aging research, Dr. Jennifer Garrison. She's an Assistant Professor at the Buck Institute for Research on Aging, the world's first institution dedicated solely to unlocking the mysteries of aging. Her groundbreaking work also extends to her roles as Assistant Professor in Residence in Cellular and Molecular Pharmacology at UCSF, and Assistant Adjunct Professor at the Leonard Davis School of Gerontology at USC.In her laboratory—aptly named the Garrison Lab—Jennifer and her team explore cutting-edge topics like Neuropeptide Signaling, the role of Neuropeptides in Aging, and particularly for today's conversation, the Role of the Brain in Ovarian Aging. Their work brings a whole new dimension to how we perceive and understand menopause, essentially shifting the paradigm and pointing to the brain as the epicenter of this life-altering transition.Now, why should you care? Because this research could redefine the way we look at aging, not just for women, but for everyone. From the rapid aging of ovaries to the global effects that menopause has on bone health, cognitive functions, and even cardiovascular well-being; Jennifer's work has profound implications.So if you've ever wondered why reproductive longevity is crucial, what menopause may signal about your overall lifespan, or how future research might completely eliminate the need for things like IVF and egg freezing, then buckle up. We'll also delve into the controversial topic of hormone replacement therapy, discuss the potential risks and benefits of having or not having children, and envision a future where anti-fibrotic drugs and high-quality oocytes could redefine what aging means for women.Get ready to have your mind expanded and your perceptions about aging and vitality redefined. This is a conversation that pushes the boundaries of what we know, and ventures into what could be possible. Let's Superhumanize!In this episode with Dr. Jennifer, you'll discover:-Jennifer's journey into medicine was inspired by a desire to find a cure for AIDS...04:15-Why reproductive longevity is essential to understanding a woman's overall health and vitality...06:05-Why do ovaries age faster than other parts of the female body?...09:05-Andropause, and how it affects both women and men...12:45-We can predict a woman's lifespan based on when they enter menopause...15:40-Is it possible to assess our menopausal cycle?...23:05-Vast disparity in resources invested in women's vs. men's health...27:30-Women need to be better informed on hormone replacement therapy(HRT)...30:25-What's on the horizon for HRT?...36:00-Anti-fibrotic drugs and means of extending the quality and lifespan of a woman's eggs...40:15-Steps women can take to improve longevity for their reproductive system and beyond...45:30-How bearing children affects a woman's reproductive health, for better or for worse...47:15-How Jennifer maximizes her own health and vitality...49:20-And much more...Resources mentioned:Global Consortium for...

Watch the full video interview on YouTube here: https://bit.ly/553drdominicdagostino Dr. Dominic D'Agostino (IG: @dominic.dagostino.kt) is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. Dom is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of metabolic-based therapies into human clinical applications. Today, we are talking all about the prevention and treatment of cancer using metabolic therapies. In this episode, we discuss: Why the ketogenic diet is a therapeutic way to treat & prevent cancer What does cancer as a metabolic disease mean? The prescription-strength ketogenic diet The ketogenic diet and latest cancer research Tumors and metastatic cancer The two fuels that feed cancer What glucose ketone index (GKI) ratio is therapeutic for cancer? Understanding blood glucose range The ketogenic diet combined with radiation The problem with chemotherapy Supplements to help manage blood glucose Supplement recommendations for cancer treatment & prevention What is the therapeutic benefit of ketones? Carbs and ketones The carnivore diet & cancer Dom's thoughts on a plant-based approach to cancer Water fasting before chemotherapy Hyperbaric oxygen therapy is beneficial for radiation necrosis How to lower glutamine naturally? Glutamine and cancer Exercise is an important component of cancer treatment An integrative approach to cancer Show sponsor: Quicksilver Scientific

I am thrilled to have Dr. Ana Andreazza, a distinguished professor at the University of Toronto, where she holds esteemed positions within the departments of Pharmacology and Toxicology, as well as Psychiatry. As the holder of a prestigious Canada Research Chair in Molecular Pharmacology of Mood Disorders, Dr. Andreazza's expertise delves into the intricate interplay between molecular pharmacology and mental health.At the forefront of groundbreaking research, Dr. Andreazza wears another significant hat as the Scientific Director of the Mitochondrial Innovation Initiative (Mito2i). Her remarkable contributions extend to the publication of over 150 research articles, garnering an impressive 9,000 citations. Dr. Andreazza's exceptional influence in the realm of mitochondrial research is particularly notable in its application to mental health, specifically mood disorders.Through her unwavering commitment to unraveling the mysteries of mitochondria and their profound impact on mental well-being, Dr. Andreazza's work revolves around comprehending how mitochondrial function intersects with neurotransmission. With an overarching focus on mood disorders, her efforts are dedicated to enhancing the lives of individuals grappling with these challenges.Join us in this enlightening episode as we delve into the world of mitochondrial research and its potential to transform our understanding of mental health, guided by the remarkable insights and expertise of Dr. Ana Andreazza.On this Episode: Introduction to Dr. Ana Andreazza2:40 Dr. Ana Andreazza's Exploration Through Mitochondria, Energy, and Mental Health8:18 Journey from studying Oxidative Stress to Redefining Mental Well-being18:17 Mitochondrial Health and Overall Well-Being26:28 Diverse origins of Psychiatric disorders 30:36 Dr. Ana's Vision for Mitochondrial Medicine and Mito2i38:57 The Vital Connection Between Ketones and Brain Health Show Links:Link to Dr. Ana Andreazza's website links: https://mito2i.ca My website is: Call to action for listeners: Follow ketones and Coffee Podcast on Instagram ( https://www.instagram.com/keton.esncoffee ), Youtube ( https://www.youtube.com/channel/UCsZZmBEenvZnU8tA1npAODA ), and Twitter ( https://twitter.com/KetonesP ) for updates and new episodes.~~~~~~Estrella by Audiorezout is licensed under a Attribution-NonCommercial-ShareAlike 4.0 International License.~~~~~~ Save yourself that trip to the market — Instacart delivers groceries in as fast as 1 hour! They connect you with Personal Shoppers in your area to shop and deliver groceries from your favorite stores.Instacart - Groceries delivered in as little as 1 hour. Free delivery on your first order over $35. Go to ketocoachlorenz.com and use the contact form to get your Free Consultation!Support the show

Dr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida. He is also a Research Scientist Institute for Human and Machine Cognition. Dom's lab develops technology that allows them to investigate the molecular, cellular, and physiological changes we experience in extreme environments, including those that would occur undersea, at high altitude, or in space. They are also designing and evaluating metabolic-based therapies as treatments for cancer and other diseases. Dom and his wife enjoy outdoor activities like going to the beach, hiking, kayaking, mountain biking, and horseback riding. They also do quite a bit of scuba diving together for his wife's marine biology research on manta rays. Data collection has taken them to Indonesia, Fiji, Palau, Hawaii, and many other phenomenal dive sites. Dom received his B.S. in Nutritional Sciences and Biological Sciences as well as his Ph.D. in Neuroscience and Physiology at Rutgers University. Afterwards, Dom conducted postdoctoral research at Wright State University and at the University of South Florida before joining the faculty at the University of South Florida. In this episode, Dom talks more about his research and tell us about his experiences in life and science.

Dr. Laura Raff is Associate Director, Sales, Immunology and Dr. Ami Ashar-Patel is a Senior Account Manager, Immunology at STEMCELL Technologies. Dr. Raff has a PhD in Molecular Microbiology and Immunology from the University of Southern California and Dr. Ashar-Patel has a PhD in Biochemistry and Molecular Pharmacology from the University of Massachusetts Chan Medical School. They talk about their career transitions from academia to industry and how they support scientists' research endeavors in their current roles.

In this episode, taken from a live a16z event, Bio + Health general partner Vineeta Agarwala moderates a panel of UCSF faculty founders, including Michelle Arkin, Jimmie Ye, and Natalia Jura (full bios below). Together, they discuss fundraising, the decision to stay in or leave  academia after founding a company, and their tips for managing the IP process. Michelle Arkin is a professor of pharmaceutical chemistry at UCSF, chair of the Department of Pharmaceutical Chemistry, and a co-director of the Small Molecule Discovery Center at UCSF. Professor Arkin is also a cofounder of both Elgin Therapeutics and Ambagon Therapeutics.Jimmie Ye is an associate professor of medicine at the Institute for Human Genetics at UCSF and an affiliate investigator at Gladstone Institutes. He is also the cofounder of Dropprint Genomics and Survey Genomics.Natalia Jura is a professor in the Department of Cell and Molecular Pharmacology and an investigator at the Cardiovascular Research Institute at UCSF. Professor Jura is also an associate director of the Quantitative Biosciences Institute. She is a cofounder of Rezo Therapeutics.

Today we have our good friend and colleague Dr. Dominic D'Agostino returning for his third appearance on STEM-Talk. Dom, as most of our longtime listeners know, is well-known for his research into the ketogenic diet and the physiological benefits of nutritional ketosis. Since our last conversation with Dom in 2019, a tremendous body of research has been added to the literature about the therapeutic potential of ketosis. The high-fat, low-carb ketogenic diet has been linked to advances in the treatment of Alzheimer's, cancer, migraines, type-2 diabetes, psoriasis, sleep apnea, psychiatric disorders, traumatic brain injuries as well as a host of other diseases and disorders, which we cover in today's interview. In episode 14 of STEM-Talk, we talked to Dom about his development and testing of metabolic therapies involving the ketogenic diet for a wide range of diseases and conditions. In episode 87, Dom returned to reflect on his 10 years of research focused on the high-fat/low-carbohydrate diet. In today's interview, we talk to Dom about this latest work as well as his extensive research on hyperbaric oxygen. Dom is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani. He specializes in neuroscience, molecular pharmacology, nutrition, and physiology. Dom also is our colleague and a research scientist here at the IHMC. Show notes  [00:02:50] Dawn opens the interview mentioning Dom's recent IHMC Evening Lecture, in which he mentions the film “First Do No Harm” starring Meryl Streep. The film is based on the true story of a four-year-old boy diagnosed with severe epilepsy, whose extreme seizures continued despite extensive medical treatments. The boy's mother reached to Dr. John Freeman, a physician who had successfully treated patients with a ketogenic diet. Dawn asks Dom to give some context about this fictional film based on a true story. [00:05:05] Dawn asks Dom to discuss the many evidence-based applications of the ketogenic diet that he highlighted in his IHMC evening lecture. [00:07:11] Ken asks Dom about another story involving Russell Winwood, a man with severe chronic obstructive pulmonary disease, also known as COPD. Russell reached out to Dom with respect to treating his COPD with a ketogenic diet. [00:11:21] Ken asks if Russell only engaged in the ketogenic diet or if also used exogenous ketones. [00:12:10] Ken mentions that the ketogenic diet has the broad potential to be an anti-inflammatory diet. Ken goes on to mention that COPD is an inflammatory disease. As Dom's case report suggested, Ken wonders if the ketogenic diet has the potential to have strong therapeutic effects for other inflammatory conditions as well. Ken asks what other conditions Dom thinks might benefit from therapeutic ketosis. [00:14:02] Dawn mentions that Dom has been busy since his last appearance on STEM-Talk, having authored or collaborated on more than 40 papers, one of which garnered a lot of attention and was published in Frontiers in Neuroscience. This paper investigated whether therapeutic ketosis via ketone esters could represent a viable way to treat epilepsy and other seizure disorders. Dawn asks Dom to elaborate on this paper's findings and their significance. [00:16:26] Ken mentions that those listeners who are unfamiliar with ketone esters may want to check out our interview with Dr. Brianna Stubbs. Ken asks Dom to give a quick primer on ketone esters and why so many researchers in the field are excited about their potential. [00:19:20] Ken mentions that in addition to ketone salts and ketone esters, there are other product formulations out now, like the one from a company called Kenetik. Ken asks Dom what he thinks about this formulation. [00:23:33] Dawn mentions that Dom has had a number of animal studies published since 2019 looking at ketone induced neuroprotection and asks Dom to give an overview of some of this...

Today we are talking with Dr. Dom D'Agostino about the latest Ketogenic diet research as a treatment for psychiatric disorders such as schizophrenia and bipolar disorder, and certain cancers.Dr. Dominic D'Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine.  He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) assisting with their efforts towards optimizing the safety, health, and resilience of the warfighter and astronaut. His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer, and metabolic wellness. He was a research investigator and crew member on NASA's Extreme Environment Mission Operation (NEEMO 22)  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations, and foundations. To learn more about Dr. Dom and his research on the ketogenic diet, visit ketonutrition.org.

Dr. Kevan M. Shokat is Professor in the Department of Cellular and Molecular Pharmacology at the University of California San Francisco, Professor in the Department of Chemistry at the University of California Berkeley, and an Investigator with the Howard Hughes Medical Institute. Kevan's lab uses approaches from chemistry to address unsolved challenges and opportunities for discovery in biology and medicine. His goal is to apply chemistry to biology in the most impactful, interesting, and meaningful ways while pursuing his curiosity. The lab has been investigating key signaling proteins in diseases such as cancer to develop new treatments. When he's not working, Kevan enjoys spending time with family, cycling with his friends, getting exercise, being out in nature, and reading biographies of scientists. Kevan received his B.A in chemistry from Reed College and his Ph.D. in organic chemistry from the University of California, Berkeley. Afterwards, he received a Life Sciences Research Foundation Fellowship to conduct postdoctoral research at Stanford University, and he served on the faculty at Princeton University before joining the faculty at his current institutions. Kevan has received numerous awards and honors over the course of his career, including the 2023 Sjöberg Prize from the The Royal Swedish Academy of Sciences, the 2023 National Academy of Sciences Award for Scientific Discovery, the 2023 Howard Vollum Award for Distinguished Accomplishment in Science and Technology from his alma mater Reed College, the 2022 American Association for Cancer Research's Award for Outstanding Achievement in Chemistry in Cancer Research, and many others. He was also named a Pew Scholar in the Biomedical Sciences, a Searle Scholar, a Cottrell Scholar, a Glaxo-Wellcome Scholar in Organic Chemistry, and an Alfred P. Sloan Research Fellow. In addition, Kevan is an elected Member of the National Academy of Sciences, a Member of the National Academy of Medicine, and a Fellow of the American Academy of Arts and Sciences. In our interview, he shares more about his life and science.

On this episode, we take a break from the regular format to talk with Itai Yanai and Martin Lercher of The Night Science Podcast, a show that explores the creative side of science with guests from across the globe. Itai is a professor in the Department of Biochemistry and Molecular Pharmacology at the NYU School of Medicine, and Martin is a professor in both the Institute for Computer Science and the Department of Biology at Heinrich Heine University Düsseldorf. We had a great time chatting with them about our respective podcast experiences, trading tips and reflecting on our passion for science communication and the ways that it has impacted our own research. Cover art by Keating Shahmehri Donate to our spring fund drive! Or, become a patron! Or both! – hey, we're not picky!

Dominic D'Agostino, Ph.D., is a tenured Associate Professor at the University of South Florida (USF) Morsani College of Medicine in the Department of Molecular Pharmacology and Physiology. He teaches medical neuroscience, medical physiology, nutrition and neuropharmacology. He is also a research scientist at the Institute for Human and Machine Cognition (IHMC). His primary research focuses on developing and testing nutritional and metabolic-based therapies for a variety of disease states and advancing the use of these therapies into human clinical applications.  

Jennifer Garrison is an assistant professor at the Buck Institute for Research on Aging and also holds appointments in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco (UCSF) and the Davis School of Gerontology at the University of Southern California.  Over 321 books from 170 plus interviews over 5 years … Dr. Jennifer Garrison: Reproductive longevity, Aging, R&D, funding – Learning with Lowell – 171 Read More »

Nick talks to Dr. Christoffer Clemmensen, who runs the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders. They discuss: the causes of obesity; environmental and biological factors influencing predisposition to obesity; novel anti-obesity drugs; gut hormones & peptides regulating food intake; whether psychedelics like psilocybin may be useful for treating obesity and other metabolic disorders. Support the showSubscribe to the audio podcast for as little as $3/month[https://www.buzzsprout.com/1535644/supporters/new]Sign up for the free weekly Mind & Matter newsletter:[https://mindandmatter.substack.com/?sort=top]Learn how you can further support the podcast: [https://mindandmatter.substack.com/p/how-to-support-mind-and-matter]

In this episode, we are joined Dr. Dominic D'Agostino, Ph.D. He is an Associate Professor with tenure at the University of South Florida where he teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition(IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.   Dr. D'Agostino chats with host Dr. Scott Sherr on manta rays being ketogenic, his early research in the field of oxidative stress, ketones in cancer, ketones and its effect on mitochondrial function, ketones and epigenetics, and so much more.   What we discussed: 00:00:22 - Introduction 00:02:12 - Manta Rays are ketogenic 00:03:54 - Is it common for fish to use ketones as fuel? 00:05:22 - How Dr. D'Agostino got into the ketogenic diet 00:08:49 - Oxidative stress 00:09:49 - Ketones in cancer 00:13:12 - The ketogenic diet 00:14:56 - The protein sparing modified ketogenic diet 00:16:24 - How Dr. D'Agostino got involved in the optimal performance world 00:19:53 - Ketones and its effects on mitochondial function 00:27:11 - Ketones and Epigenetics 00:30:43 - Dr. D'Agostino's thoughts on ketones over the years 00:34:02 - The mechanism of a ketone induced increase in insulin 00:38:18 - Maintaining ketosis for long periods of time 00:45:07 - The Ketogenic diet and neurotransmitters 00:54:16 - Effects of long term ketogenic diets of menstrual cycle 00:56:26 - Ketonegic diet and microbiome 01:01:49 - The best way to keep your glucose from spiking 01:04:11 - Ketogenic diet and endocannabinoid system 01:07:21 - Dr. D'Agostino's exciting project on metabolic psychiatry   Find more from Smarter, Not Harder: Website: https://troscriptions.com/blogs/podcast / https://homehope.org Instagram: @troscriptions | @homehopeorg   Find out more about Dr. Dominic D'Agostino: Website: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/dominicdagosti2 Instagram: https://www.instagram.com/dominic.dagostino.kt/     Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at https://www.homehope.org   Get 10% Off your Trosciptions purchase by using POD10 at https://www.troscriptions.com   Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.   

In this talk show we're pulling back the curtain on one of the great mysteries in women's health.  Menopause doesn't have to be scary if we understand everything we can about one of our most vital  organs - the Ovaries. Please join our friends Jennifer Garrison and Deena Emera from the Buck Institute for our live talk show this Wednesday.  Jennifer Garrison is an assistant professor at the Buck Institute for Research on Aging and also holds appointments in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco (UCSF) and the Davis School of Gerontology at the University of Southern California. She is also the Co-Founder & Director, Global Consortium for Reproductive Longevity & Equality.Deena Emera is a Senior Scientist and Writer-in-Residence in the Center for Reproductive Longevity and Equality at the Buck Institute, where she is drawing on her evolutionary background and expertise on female reproduction to investigate the evolution of menopause.  She also continues working with students, teaching a science-writing course at Dominican University.  Her book A Modern Guide to the Female Body will be published in the spring of 2023.

HVMN Podcast Podcast Notes Key Takeaways Explosion of ketones as a field of study: (1) ketones are a potent but accessible intervention (legal, accessed through diet or exogenous; (2) scientists are living the lifestyle of what they're studying which helps credibility, influence, experience“Ketones can rapidly change brain energy metabolism and the neuropharmacology of your brain in a way that's neuroprotective and anti-seizure.” – Dr. Dom D' AgostinoThere should be a duty to disseminate translatable, clear research to the public if funded through government meansKetones improve brain energy signaling metabolism, resilience, and enhance ability to maintain cognitive and physical performance in extreme environments – both environmental and physiologicEven within the ketogenic diet, there are many routes to go and options for exogenous ketones as supplement – like any diet, it needs to be personalized to your needs (a continuous glucose monitor can help)Starting in early middle age, natural uptake of glucose declines but ketone uptake is retained in the aging brain – ketones can circumvent glucose transporter and provide the energy for proper functionThe greatest effect of ketogenic diet on athletic performance will likely be over time where you'll see improvements in recovery, epigenetic effects, anti-inflammatory effectsTip: consuming carbohydrates with exogenous ketones (such as a ketone salt, MCT) will minimize glycemic variability  “Completely excluding carbohydrates, fruit, and vegetables to the extent we do that with a clinical ketogenic diet is not optimal [for everyday]. A more diverse diet with plants, vegetables, different protein sources, with exogenous ketones would be more optimal.” – Dr. Dom D'AgostinoInstead, try a Mediterranean diet with exogenous ketones for supplementation with about 50-100g carbohydratesRead the full notes @ podcastnotes.orgDr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative.   Dr. Latt Mansor and Geoff Woo met Dr. D'Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022.   Key point topics and studies mentioned: Role of ketones and the future direction of ketone research in: Athletic performance/ extreme environment Mitochondrial protection in astronauts in space Cancers Metabolic psychiatry Alzheimer's and dementia Optimal blood ketone levels for health benefits Keto vs. carnivore vs. plant-based diets H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans, and we want to give you a special reward. Use HVMNPOD10 to get 10% off your next H.V.M.N. order. _______________________________________________________________ Learn More About H.V.M.N. here: https://hvmn.com/pod Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions! 

HVMN Podcast Podcast Notes Key Takeaways Explosion of ketones as a field of study: (1) ketones are a potent but accessible intervention (legal, accessed through diet or exogenous; (2) scientists are living the lifestyle of what they're studying which helps credibility, influence, experience“Ketones can rapidly change brain energy metabolism and the neuropharmacology of your brain in a way that's neuroprotective and anti-seizure.” – Dr. Dom D' AgostinoThere should be a duty to disseminate translatable, clear research to the public if funded through government meansKetones improve brain energy signaling metabolism, resilience, and enhance ability to maintain cognitive and physical performance in extreme environments – both environmental and physiologicEven within the ketogenic diet, there are many routes to go and options for exogenous ketones as supplement – like any diet, it needs to be personalized to your needs (a continuous glucose monitor can help)Starting in early middle age, natural uptake of glucose declines but ketone uptake is retained in the aging brain – ketones can circumvent glucose transporter and provide the energy for proper functionThe greatest effect of ketogenic diet on athletic performance will likely be over time where you'll see improvements in recovery, epigenetic effects, anti-inflammatory effectsTip: consuming carbohydrates with exogenous ketones (such as a ketone salt, MCT) will minimize glycemic variability  “Completely excluding carbohydrates, fruit, and vegetables to the extent we do that with a clinical ketogenic diet is not optimal [for everyday]. A more diverse diet with plants, vegetables, different protein sources, with exogenous ketones would be more optimal.” – Dr. Dom D'AgostinoInstead, try a Mediterranean diet with exogenous ketones for supplementation with about 50-100g carbohydratesRead the full notes @ podcastnotes.orgDr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative.   Dr. Latt Mansor and Geoff Woo met Dr. D'Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022.   Key point topics and studies mentioned: Role of ketones and the future direction of ketone research in: Athletic performance/ extreme environment Mitochondrial protection in astronauts in space Cancers Metabolic psychiatry Alzheimer's and dementia Optimal blood ketone levels for health benefits Keto vs. carnivore vs. plant-based diets H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans, and we want to give you a special reward. Use HVMNPOD10 to get 10% off your next H.V.M.N. order. _______________________________________________________________ Learn More About H.V.M.N. here: https://hvmn.com/pod Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions! 

Dr. Dominic D'Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative. Dr. Latt Mansor and Geoff Woo met Dr. D'Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022. Key point topics and studies mentioned: Role of ketones and the future direction of ketone research in: Athletic performance/ extreme environment Mitochondrial protection in astronauts in space Cancers Metabolic psychiatry Alzheimer's and dementia Optimal blood ketone levels for health benefits Keto vs. carnivore vs. plant-based diets H.V.M.N. Podcast Fam: We're giving you an exclusive offer. You guys are some of our most loyal fans, and we want to give you a special reward. Use HVMNPOD10 to get 10% off your next H.V.M.N. order. _______________________________________________________________ Learn More About H.V.M.N. here: https://hvmn.com/pod Send a message to podcast@hvmn.com with feedback, questions, and guest suggestions! 

Joining me on the podcast today is Jennifer Garrison PhD. Jennifer is an assistant professor at the Buck Institute for Research on Aging and also holds appointments in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco (UCSF) and the Davis School of Gerontology at the University of Southern California.Dr. Garrison's research focuses on understating how chemical communication between the brain and other tissues influence aging. Running a research lab is just one part of Dr. Garrison's work. Understanding aging on a molecular level is a key part of her work at the Buck Institute. The goal is to understand the underlying causes of aging as a way to tackle multiple diseases at the same time. “The goal is to increase health span . . . increase that period of time when you are healthy.”  Jennifer Garrison Jennifer explains that she believes that the brain is the key player for systemic aging. She explains how the brain is controlling what's happening, by listening to and recording feedback from all the organs in your body. Dr. Garrison organized the International Scientific Conference Focused on Reproductive Aging. As we make progress extending healthy longevity, reproductive longevity must also be addressed. It's not just a physical issue but affects gender equality as well. A goal is to get rid of menopause and if that's not possible, then to extend it until much later in life. There's a lack of understanding about why women experience menopause at all. Jennifer paints the big picture that is fascinating. Did you know that only humans and a few species of whales even experience menopause? The research is underfunded, and Dr. Garrison is advocating that scientists and clinicians to talk and collaborate about these issues. The male body has been the baseline. Researching women's bodies is still underfunded and Dr. Garrison along with organizations like the Bone Health and Osteoporosis Foundation are trying to bring awareness and the need for more research. Funding is key to bringing the scientists and physicians together who can begin to answer fundamental questions about women's bodies and reproductive health. What should every woman know about reproductive aging? The ovary isn't just for fertility. It produces endocrine hormones and other chemicals that are essential for general health that have nothing to do with fertility. Those functions are what Dr. Garrison wants to learn how they can be extended to improve overall health. Reproductive aging centers around equality. Every aspect of a woman's life is affected by the fact that she will go through a decline when menopause begins. Dr. Garrison wants this to be a conversation that's reframed with a holistic point of view. It's a unique time in history to be able to marry reproductive health with longevity. Ambassadors are welcome to have conversations about women's health and the incredible work being done by Dr. Garrison and others. Connect with Dr. Garrison: Buck InstituteSupport the show

Dr. Dominic D'Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, brain cancer and metastatic cancer.

Dominic D'Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health, and resilience of the warfighter and astronaut. His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity (seizures), epilepsy, neurodegenerative diseases, and cancer. The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. The shift in brain metabolism (from glucose to ketones) reduces neuronal hyperexcitability, oxidative stress and enhances brain energy metabolism. This approach can be used to treat a wide variety of pathologies linked pathophysiologically to metabolic dysregulation, including cancer. Follow Dr. D'Agostino at https://www.ketonutrition.org/ and https://dominicdagostino.wordpress.com/Integrative Cancer Solutions was created to instill hope and empowerment. Other people have been where you are right now and have already done the research for you. Listen to their stories and journeys and apply what they learned to achieve similar outcomes as they have, cancer remission and an even more fullness of life than before the diagnosis. Guests will discuss what therapies, supplements, and practitioners they relied on to beat cancer. Once diagnosed, time is of the essence. This podcast will dramatically reduce your learning curve as you search for your own solution to cancer. For more information about products and services discussed in this podcast, please visit www.integrativecancersolutions.com. To learn more about the cutting-edge integrative cancer therapies Dr. Karlfeldt offer at his center, please visit www.TheKarlfeldtCenter.com.

Dr. Dominic D'Agostino is a tenured Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He runs the website KetoNutrition and has been on over 200 podcasts talking about metabolic health. He is also a Research Scientist at the Institute for Human and Machine Cognition. His laboratory develops and tests metabolic-based strategies for targeting CNS oxygen toxicity, epilepsy, neurodegenerative diseases, brain cancer, and metastatic cancer.The main focus of his lab over the last 12 years has investigating the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. This approach can be used to treat a wide variety of pathologies linked pathophysiologically to metabolic dysregulation. Other areas of interest include researching metabolic-based drugs for cancer.He was a research investigator and crew member on NASA's Extreme Environment Mission Operation and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments. His research is supported by the Office of Naval Research, Department of Defense, private organizations and foundations.

This episode featured Dr. Dom D'Agostino- the world's pre-eminent ketone scientist! We discuss the concept of a PSMKD (Protein Sparing Modified Ketogenic Diet) to Optimize Protein Intake for Fat Loss & Protecting Muscle While Gaining the Benefits of Ketosis, Measuring Breath Acetone & More! His thoughts on breath acetone to monitor fat loss, having a glucose to breath acetone index, why having high BHB may not be optimal for health under certain scenarios, and much more!! Dr. Dominic D'Agostino is a Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida and Research Scientist at the Institute for Human and Machine Cognition (IHMC).  His laboratory develops and tests metabolic-based strategies for neurological disorders, cancer, and for enhancing safety and resilience of military personnel in extreme environments.  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. For more from Dr. D'Agostino, visit https://ketonutrition.org/ Check out the Metabolic Health Summit! You can still watch all of the talks! For 15% OFF tickets, go to www.metabolichealthsummit.com and enter the code KETOGENICGIRL in the ticket checkout process - or visit this link with the discount already applied: www.eventbrite.com/e/82259332879/?discount=Ketogenicgirl (the promo code location can be hard to spot! Some of the studies mentioned in this episode:  Measuring breath acetone for monitoring fat loss Study with measuring Acetone & Latency to Seizure George Cahill fasting study & what initiates ketosis. Ketones as a super fuel  Virta study long term BHB levels FAQ on the Acetone, Ketones & The Tone  Introducing the brand new TONE Device! Struggling to lose weight or reach your fitness goals? The TONE is a new breath acetone meter which lets you know if your body is burning fat!  All TONE devices are NOW SHIPPING Worldwide!! Order the TONE here. Now shipping worldwide!!  Order the Black & Gold TONE HERE Order the Black & Rose Gold TONE HERE Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl Try the Higher Protein Keto Meal Plans & Coaching: https://www.ketogenicgirl.com - Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

This episode is featuring Dr. Dom D'Agostino- the world's pre-eminent ketone scientist! We discuss using breath acetone to monitor fat loss, understanding how to measure various ketones, fasting and ketosis, acetone's powerful effects on latency to seizure, acetone to BHB ratios and what determines the ratio of BHB to acetoacetate, why having high BHB may not be optimal for health under certain scenarios, and much more!! Dr. Dominic D'Agostino is a Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida and Research Scientist at the Institute for Human and Machine Cognition (IHMC).  His laboratory develops and tests metabolic-based strategies for neurological disorders, cancer, and for enhancing safety and resilience of military personnel in extreme environments.  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. For more from Dr. D'Agostino, visit https://ketonutrition.org/ Check out the upcoming Metabolic Health Summit! For 15% OFF tickets, go to www.metabolichealthsummit.com and enter the code KETOGENICGIRL in the ticket checkout process - or visit this link with the discount already applied: www.eventbrite.com/e/82259332879/?discount=Ketogenicgirl (the promo code location can be hard to spot! Some of the studies mentioned in this episode:  Measuring breath acetone for monitoring fat loss Study with measuring Acetone & Latency to Seizure George Cahill fasting study & what initiates ketosis. Ketones as a super fuel  Virta study long term BHB levels FAQ on the Acetone, Ketones & The Tone  Introducing the brand new TONE Device! Struggling to lose weight or reach your fitness goals? The TONE is a new breath acetone meter which lets you know if your body is burning fat!  All TONE devices are NOW SHIPPING Worldwide!! Order the TONE here. Now shipping worldwide!!  Order the Black & Gold TONE HERE Order the Black & Rose Gold TONE HERE Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast. Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/ Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl Try the Higher Protein Keto Meal Plans & Coaching: https://www.ketogenicgirl.com - Prior to beginning a ketogenic diet you should undergo a health screening with your physician to confirm that a ketogenic diet is suitable for you and to rule out any conditions and contraindications that may pose risks or are incompatible with a ketogenic diet, including by way of example: conditions affecting the kidneys, liver or pancreas; muscular dystrophy; pregnancy; breast-feeding; being underweight; eating disorders; any health condition that requires a special diet [other conditions or contraindications]; hypoglycemia; or type 1 diabetes. A ketogenic diet may or may not be appropriate if you have type 2 diabetes, so you must consult with your physician if you have this condition. Anyone under the age of 18 should consult with their physician and their parents or legal guardian before beginning such a diet. Use of Ketogenic Girl videos are subject to the Ketogenicgirl.com Terms of Use and Medical Disclaimer. All rights reserved. If you do not agree with these terms, do not listen to, or view any Ketogenic Girl podcasts or videos.

Dominic D'Agostino, Ph.D., has maintained involvement in a vast array of professional, academic and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation. This episode is hosted by Dr. Shawn Baker MD. Find him at https://shawn-baker.com Timestamps 00:00 Research and ongoing clinical trial 04:53 How many cows does Dominic have? 09:19 Inflammation, neuro-inflammation 12:48 Chronic ketosis 17:13 Ketone disposal 20:17 Low blood glucose in context of ketogenic diet 23:09 Brain consumer of ketones 24:57 Metabolic flexibility 28:31 Facilitating ketosis in metabolically resistant people 31:01 Gluconeogenesis 34:15 Is there a deleterious effect to relying on carbs ingested? 35:35 Hypoketotic and hypoglycemic 38:05 The dose makes the poison 40:19 Circadian timing of meals 43:43 Traumatic brain injury 47:23 Cancer and ketogenic diets 52:21 Gut permeability 55:19 Calorie restricted diets vs ketogenic diets 57:30 Higher protein diets in the context of cancer or aging 59:25 Longevity vs function 61:40 Experiments on lab rats https://revero.com Invest In Revero: https://republic.com/revero Fill Out the Food Reaction Survey: https://www.questionpro.com/t/AUBnjZpQqC Book a Carnivore Coach: https://revero.com/book-a-coach/ Book a Coaching Session: https://revero.com/book-a-coach/ Carnivore Shirts: https://merch.revero.com Subscribe to our Newsletter: https://revero.com/subscribe/ Join the Community: https://revero.com/join/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation #humanfood #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree ‪

This week I am talking with Itai Yanai, Director of the Institute for Computational Medicine and Professor of Biochemistry and Molecular Pharmacology at NYU. We discuss Richard Dawkin's book: The Selfish Gene, Darwin's work with Evolution and Itai's Podcast: The Night Science Podcast. Throughout the conversation we dive into extended phenotypes, spandrels in genetics, and evolution of things like facial hair and tails. Thank you for watching and being an inquisitive being.

Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut. His lab develops and tests metabolic therapies, including calorie restriction protocols, intermittent fasting, ketogenic diets and exogenous ketones (ketone supplements) for CNS oxygen toxicity (seizures), epilepsy, metabolic disorders, Alzheimer's disease, ALS, muscle wasting, cancer and human performance applications. Personal Website: https://www.ketonutrition.org/Dom's Linktree: https://linktr.ee/DomdagostinoContact Mikki:https://mikkiwilliden.com/https://www.facebook.com/mikkiwillidennutritionhttps://www.instagram.com/mikkiwilliden/https://linktr.ee/mikkiwillidenSave 20% on all NuZest Products with the code MIKKI20 at www.nuzest.co.nzSave 30% on Hoka One One with the code TEAMMIKKI at www.Hoka.co.nz

Let's Go to Space BLUESKY Learning is part of a larger educational initiative called the Aerospace and Innovation Academy, which seeks to provide unique and distinctive stem opportunities for passionate middle and high schoolers. While we often highlight careers in aerospace, today's podcast is the third in a series where we have been hearing from parents of students who have incredible resume builders to hear how they believe the program has impacted their child. This is our second episode in the series. Dr. Ruhi Ahmed currently serves as Senior Vice President of Regulatory and Government Affairs at two companies: FLAG Therapeutics Inc.and at Asceneuron She has nearly 20 years of experience in the pharmaceutical and biotechnology. Dr. Ahmed earned her B.S. in Biology and M.A. in Biochemistry from The University of Texas at Austin, and her M.S. in Regulatory Sciences and Ph.D. in Molecular Pharmacology and Toxicology from the University of Southern California.. Today, she is the proud mom of seventh grader Argyrios Vaitsos who spoke recently at the Hawaiian International Conference of Education Gary Vescio is Managing Director of SOUND Wealth Management Group which is a leading financial management and advisory group affiliated with Raymond James. He is also a former executive of a Fortune 200 technology firm and holds an MBA from the University of Miami. He and his wife Jackie are the parents of 3 boys - the oldest, Michael, who is currently enrolled at the University of Pennsylvania Law School and was an inaugural member of our Cube-Sat program; and twins Elliott and Tyler who are members of the team today. SHOW NOTE: Mr. Vescio appears about halfway through due to a log-in issue. --- Support this podcast: https://anchor.fm/shawna-christenson2/support

In this episode of the Mother Plus Podcast, we cover:When a career change upended Mandy's identity, she used her background in both biochemistry and mindset to create a business supporting the mental health of  prospective medical students who are preparing for the MCAT. Why and how Mandy made a professional pivot during the pandemic. What happens when the right thing for your family isn't the best for your career? Mandy shares her guilt-free perspective and why work makes her a better mom. Honor your motherhood style: why a “one size fits all” approach doesn't work when it comes to parenting choices. Small, incremental steps are the key to success: Be authentic and follow your gut when starting your business-- you do not have to do what everyone else is doing or have everything perfect.Mandy Siglin has a lot of titles: Mother to three + PhD, yoga instructor and mindset coach. Siglin received her PhD in Molecular Pharmacology and Structural Biology from Thomas Jefferson University.  She lovingly served as the Director of Juniata College's Health Professions Program for five years. When family circumstances took her away from her Director position right before the pandemic hit, she had to make a pivot. Inspired by her ability to change the students she worked with in the past with her unique science and mindset perspective, she founded ThiveMed, a company dedicated to the wellbeing of pre-med students. Mandy uses strategic, evidence-based practices to help students increase their confidence and lower their stress and anxiety around standardized entrance exams for admission to professional school. Mandy lives in North Carolina with her husband, Josh, and three children.Where you can find her:Instagram: https://www.instagram.com/thrive.med/LinkedIn: https://www.linkedin.com/in/mandy-siglin-a783955a/

Tune in to episode 64 of 17 Minutes of Science as we talk with Dr. Deborah Kurrasch about her recent paper and why she enjoys working with zebrafish so much! Dr Deborah Kurrasch is a Professor in the Department of Medical Genetics at the University of Calgary and a Scientist in the Alberta Children's Hospital Research Institute and the Hotchkiss Brain Institute. Dr Kurrasch's research is focused on characterizing the genetic programs that govern hypothalamic development, and how exposure to environmental chemicals changes these programs, using zebrafish, mice and human brain organoids as model organisms. Her lab has also developed a novel drug screening platform to uncover therapies for children with refractory epilepsy. Her work is funded by the Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, and Canadian Foundation for Innovation, among other Foundations. Dr Kurrasch received her PhD in Molecular Pharmacology from Purdue University and conducted two postdoctoral fellowships, one at the University of Texas – Southwestern Medical Center in Dallas and one at the University of California – San Francisco. Dr Kurrasch has received various awards for her scholarly work and supervision of graduate students, most recently receiving the ASTech Women in Innovation award, 2021.

Dom D'Agostino, Ph.D., is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). Layne Norton is a renowned prep/physique coach and pro-natural bodybuilder/powerlifter with a PhD in Nutritional Sciences.

Dom D'Agostino, Ph.D., is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He was also recently a crew member of the NASA NEEMO 22 project.