Podcast appearances and mentions of daniel mr

CardioNerds (Drs. Natalie Marrero, Shivani Reddy, and Rebecca S. Steinberg), discuss the role of SGLT2i in cancer therapy-related cardiac dysfunction (CTRCD) with Dr. Manu Murali Mysore. This episode was produced as part of the CardioNerds Academy curriculum by House Taussig under the guidance of House Chief, Dr. Natalie Marrero, and Academy Program Director, Dr. Gurleen Kaur. A matching review article will be published in US Cardiology Review, the official journal of CardioNerds. Audio editing for this episode was performed by CardioNerds Intern, Dr. Julia Marques Fernandes. Summary: Cancer therapy-related cardiac dysfunction (CTRCD) spans a spectrum from subclinical biomarker elevation to overt heart failure, with risk amplified by preexisting cardiovascular disease, diabetes, hypertension, obesity, and exposure to therapies, such as anthracyclines, HER2-targeted therapies, or radiation. This episode explores the emerging and promising role of SGLT2 inhibitors as a cardioprotective adjunct in cardio-oncology — examining mechanisms, clinical evidence, ongoing trials, and critical knowledge gaps — while affirming that guideline-directed medical therapy remains the cornerstone of prevention and treatment. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Cardio-Oncology PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls CTRCD is a spectrum — catch it early. CTRCD ranges from subclinical injury detected by imaging and biomarkers to overt heart failure. Early identification in high-risk patients (preexisting CVD, diabetes, HTN, obesity, anthracycline/HER2/radiation exposure) is essential, and early initiation of guideline-directed medical therapy — including ACE inhibitors/ARBs/ARNIs, mineralocorticoid receptor antagonists, and beta-blockers — remains the backbone of prevention and treatment to preserve LVEF and allow safe continuation of cancer therapy. SGLT2 inhibitors are a promising new pillar of cardioprotection in cardio-oncology. They act through a unique combination of mechanisms: renal effects, metabolic reprogramming of the myocardium, anti-inflammatory and antioxidant pathways, and vascular fibrosis modulation — making them a compelling complement to standard therapies rather than a replacement. Early clinical data is encouraging but not yet definitive. The 2024 EMPACARD-PILOT trial demonstrated preserved LVEF and reduced CTRCD in higher-risk patients with diabetes or kidney disease. Ongoing trials — EMPACT and PROTECT — are actively exploring SGLT2 inhibitors for primary prevention during anthracycline and HER2-targeted therapy. SGLT2 inhibitors are NOT yet indicated for ICI-related myocarditis. Immune checkpoint inhibitor (ICI)-related myocarditis is mechanistically immune-driven. While SGLT2 inhibitors have theoretically anti-inflammatory benefits, there is currently no clinical evidence to support their use in this specific setting. The use of SGLT2 inhibitors should be guided by patient risk, existing indications, and ongoing research. Large prospective trials, clarity on timing and patient selection, long-term safety data, and deeper mechanistic understanding in humans remain the most urgent gaps in the field before broader adoption can be recommended. References Theofilis P, Vlachakis PK, Oikonomou E, et al. Cancer therapy-related cardiac dysfunction: A review of current trends in epidemiology, diagnosis, and treatment. Biomedicines. 2024;12(12):2914. doi:10.3390/biomedicines12122914. https://pubmed.ncbi.nlm.nih.gov/39767820/ Lyon AR, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020;22(11):1945-1960. doi:10.1002/ejhf.1920. https://pmc.ncbi.nlm.nih.gov/articles/PMC8019326/ Li X, Li Y, Zhang T, et al. Role of cardioprotective agents on chemotherapy-induced heart failure: A systematic review and network meta-analysis of randomized controlled trials. Pharmacol Res. 2020;151(104577):104577. doi:10.1016/j.phrs.2019.104577. https://pubmed.ncbi.nlm.nih.gov/31790821/ Lee YH, Lim S, Davies MJ. Cardiometabolic and renal benefits of sodium-glucose cotransporter 2 inhibitors. Nat Rev Endocrinol. 2025;21(12):783-798. doi:10.1038/s41574-025-01170-4. https://pubmed.ncbi.nlm.nih.gov/40935880/ Dabour MS, George MY, Daniel MR, Blaes AH, Zordoky BN. The cardioprotective and anticancer effects of SGLT2 inhibitors: JACC: CardioOncology state-of-the-art review. JACC CardioOncol. 2024;6(2):159-182. doi:10.1016/j.jaccao.2024.01.007. https://pubmed.ncbi.nlm.nih.gov/38774006/ Armillotta M, Angeli F, Paolisso P, et al. Cardiovascular therapeutic targets of sodium-glucose co-transporter 2 (SGLT2) inhibitors beyond heart failure. Pharmacol Ther. 2025;270(108861):108861. doi:10.1016/j.pharmthera.2025.10886. https://pubmed.ncbi.nlm.nih.gov/40245989/ Góes-Santos BR, Castro PC, Girardi ACC, Antunes-Correa LM, Davel AP. Vascular effects of SGLT2 inhibitors: evidence and mechanisms. Am J Physiol Cell Physiol. 2025;329(4):C1150-C1160. doi:10.1152/ajpcell.00569.2025. https://pubmed.ncbi.nlm.nih.gov/40908107/ Daniele AJ, Gregorietti V, Costa D, López-Fernández T. Use of EMPAgliflozin in the prevention of CARDiotoxicity: the EMPACARD – PILOT trial. CardioOncology. 2024;10(1):58. doi:10.1186/s40959-024-00260-y. https://pubmed.ncbi.nlm.nih.gov/39237985/ Clinicaltrials.gov. Clinicaltrials.gov. Accessed April 16, 2026. https://clinicaltrials.gov/study/NCT05271162 Greco A, Quagliariello V, Rizzo G, et al. SGLT2i Dapagliflozin in primary prevention of chemotherapy induced cardiotoxicity in breast cancer patients treated with neo-adjuvant anthracycline-based chemotherapy +/- trastuzumab: rationale and design of the multicenter PROTECT trial. CardioOncology. 2025;11(1):79. doi:10.1186/s40959-025-00368-9. https://pmc.ncbi.nlm.nih.gov/articles/PMC12400668/ Key Guideline Reference: Lyon AR, López-Fernández T, Couch LS, et al. 2022 ESC guidelines on cardio-oncology developed in collaboration with the European hematology association (EHA), the European society for therapeutic radiology and oncology (ESTRO) and the international cardio-oncology society (IC-OS). Eur Heart J Cardiovasc Imaging. 2022;23(10):e333-e465. doi:10.1093/ehjci/jeac106. https://pubmed.ncbi.nlm.nih.gov/36017575/ Be sure to check out the corresponding review article on the cardioprotective role of SGLT2 inhibitors in CTRCD that will be published in US Cardiology Review, the official journal of CardioNerds. Additionally, please reference CardioNerds Cardio-Oncology Episodes 261 and 274 for related content.

This Week in Skating is hosted by Gina Capellazzi and Daphne Backman and is a cooperative project between Figure Skaters Online and Ice-dance.com. New episodes are available every Tuesday.Website: http://www.thisweekinskating.comEmail: thisweekinskating@gmail.comFacebook: https://www.facebook.com/thisweekinskatingTwitter: https://www.twitter.com/thiswkinskatingInstagram: https://www.instagram.com/thisweekinskatingThread: https://www.threads.net/@thisweekinskatingPatreon: patreon.com/ThisWeekinSkating---------------------------------------------------------------------------------------------Skating News Worlds NewsXizi Chen / Jianing Xing replace Shiyue Wang / Xinyu Liu at WorldsMark Gorodnitsky was confirmed officially as Israel's men's entryhttps://results.isu.org/events/fsevent00117492.htmDeniss Vasiljevs will debut a new free program at Worlds to music of the Lion King movie. The selections are “The Rightful Knight” by Hans Zimmer and “He Lives in You” bu Kesha Shantrell and Matt Bloyd. https://twitter.com/goldenskate/status/1769004296425668928Event Results Brief:Coupe du Printemps - https://cdp2024.online/2024/CDP/index.htmWorld Junior Synchronized Championshipshttp://www.isuresults.com/results/season2324/wjsysc2024/CAT001RS.htmRecent Interview and ArticlesBeverley Smith's Pre-Worlds articles: Gilles and Poirier ready for goldMadeline Schizas and the twiddly bitsA brain waveEurope on Ice (Hiro Yoshida): Soucisse and Firus: Exploring new horizons Adam Siao Him Fa flipping skating on its headSmart and Dieck finding their nicheOlympics.com (Nick McCarvel): Olympians explain the making of a figure skating program: "We always have something to work on""I'm carving my own path": Jason Brown on his one-of-a-kind quest – and openness to the 2026 OlympicsGoldenSkate: Anthony Paradis: A peek behind the glam Anything GOEs: DeMougeot and LeMercier thrive on their differencesWesley Chiu's appearance on CTV Morning Livehttps://bc.ctvnews.ca/video?clipId=2884509Social Media Updates:Solene Mazingue's vlogs chronicling her 2 weeks before Worlds : https://www.youtube.com/playlist?list=PLuopiQHPd7LzGGDH_s4oxPAihzYhg55HhRoman Sadovsky's vlog (Canadian Nationals/4CC/practice footage before Worlds): https://www.youtube.com/watch?v=nhvvBei2-2QScott Hamilton received the first-ever Midas Touch Golden Legacy Award at the 11th Annual Gold Meets Golden Event in Los Angeles, presented by Coca Cola. Kristi Yamaguchi presented him the award: https://twitter.com/ScottHamilton84/status/1767652655508201652IDC and FSO spotlightNew at IDC: Czech Republic's Kateřina Mrázková and Daniel Mrázek Exhibition and practice photos from Junior WorldsNew at FSO: 2024 ISU World Championships HubReturning to Lillehammer 30 years laterSupport this podcast at — https://redcircle.com/this-week-in-skating-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Daniel “Mr. Clutch” Mercado Castro analiza lo ocurrido en los NBA Playoffs

Daniel “Mr. Clutch” Mercado Castro analiza lo ocurrido en la NBA

Daniel “Mr. Clutch” Mercado Castro analiza el cierre de temporada, el Play In y los Playoffs de la NBA 2022-2023

In today's episode, Brittny chats with Daniel Drew, a.k.a- Mr. Myo. Daniel Drew, M.S. CCC-SLP OMT CertBBM is a Speech Language Pathologist, Certified Buteyko Breathing Practitioner, and Orofacial Myofunctional Therapist. Daniel is currently seeing clients at the Center for Airway and Facial Development and Pain and Sleep Therapy Center in Newark, Delaware. He has over 10 years of experience as a hospital-based Speech-Language Pathologist. He is versed in a variety of settings including outpatient settings and inpatient rehabilitation hospitals. He treats complex pediatric and adult clients with previously unremediated articulation (speech) difficulties, tongue ties, dysphagia (difficulty swallowing), and other muscle-function disorders. Daniel provides education to local healthcare providers in the Delaware and Pennsylvania regions about the benefits of Orofacial Myofunctional Therapy to treat sleep, breathing, feeding, and speech disorders in children and adults. He is anadvocate for airway health and early intervention to address the epidemic of sleep-related breathing disorders in the pediatric population. In 2022, Daniel started his Mr. Myo Myofunctional Therapy brand and social media presence. @Mr_Myo302 follows Daniel's persona “Mr. Myo” as he works with children on myofunctional therapy exercises and gets them “pumped up” and excited about being active, improving their health, and creating good habits.You can follow Daniel “Mr. Myo” on Instagram and Youtube @Mr_Myo302Center for Airway and Facial Development and Pain and Sleep Therapy Center in Newark, Delaware:https://airwayandfacialdevelopment.com/

Daniel “Mr. Clutch” Mercado Castro nos habla de lo ocurrido en la Serie Mundial 2022

On today's episode of WHAT THE TRUCK?!? Dooner and The Dude are joined by special guest host Daniel "Mr. Supply Chain” Stanton to talk about holiday retail supply chain bullwhips, Supply Chain Management for Dummies and teaching logistics to America's young minds.Where's the peak? Uber Freight's Ben Cubitt talks about it latest market report that's seeing consumer spending slow, inventories expand and order backlogs decline.Got an air freight emergency? That's what Carrier 911 is for, and Port X Logistics Brian Kempisty is here to tell us all about it. Maybe we'll even learn what the hardest hike in logistics is.CFI's Joel Schneider shares strategies for surviving and thriving in uncertain times.Plus, Torc autonomous truck initial impressions; freight executives start roadside health network for drivers; New Jersey bans cheeky road signs; striking truckers; and getting your rig ready for winter.Visit our sponsorWatch on YouTubeSubscribe to the WTT newsletterApple PodcastsSpotifyMore FreightWaves Podcasts

On today's episode of WHAT THE TRUCK?!? Dooner and The Dude are joined by special guest host Daniel "Mr. Supply Chain” Stanton to talk about holiday retail supply chain bullwhips, Supply Chain Management for Dummies and teaching logistics to America's young minds.Where's the peak? Uber Freight's Ben Cubitt talks about it latest market report that's seeing consumer spending slow, inventories expand and order backlogs decline.Got an air freight emergency? That's what Carrier 911 is for, and Port X Logistics Brian Kempisty is here to tell us all about it. Maybe we'll even learn what the hardest hike in logistics is.CFI's Joel Schneider shares strategies for surviving and thriving in uncertain times.Plus, Torc autonomous truck initial impressions; freight executives start roadside health network for drivers; New Jersey bans cheeky road signs; striking truckers; and getting your rig ready for winter.Visit our sponsorWatch on YouTubeSubscribe to the WTT newsletterApple PodcastsSpotifyMore FreightWaves Podcasts 

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo ocurrido en la MLB

Daniel “Mr. Clutch” Mercado Castro te analiza lo que debes saber rumbo a la nueva temporada

Daniel “Mr. Clutch” Mercado Castro resume y analiza lo ocurrido en la MLB

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo ocurrido en los MLB Wild Card 2022

Daniel “Mr. Clutch” Mercado Castro resume y analiza lo ocurrido en la MLB

A roundtable of LL patients joins the panel! www.cyborg4life.com --- Support this podcast: https://anchor.fm/leglengthening/support

Daniel “Mr. Clutch” Mercado Castro repasa lo sucedido en la MLB en las pasadas semanas

Daniel “Mr. Clutch” Mercado resume y analiza lo sucedido en la MLB

On today's episode Dooner and The Dude are talking to Daniel “Mr. Supply Chain” Stanton about how the supply chain bullwhip effect has impacted freight this year. Will inventory overflows be the grinch that stole carriers Christmas?The second-largest cost for operating a truck is fuel (especially this year!) Chris Jones, EVP of industry and services at Descartes, shares how tech is helping to reduce this cost burden for carriers. Wars are won with logistics, so it is no surprise that this industry is a welcoming home to veterans. However, how can we better support our servicemen and women when they enter civilian life? Ivan Hernandez, owner at Vets2Trucking, shares how he is helping to get vets into the cab.Plus, DAT and Convoy's legal battle; outbound tender rejects fall below 6% for first time in 25 months; FMC considers congestion emergency order; sleeping CDL school instructors; and the true menace of bouncy castles.   Visit our sponsorWatch on YouTubeSubscribe to the WTT newsletterApple PodcastsSpotifyMore FreightWaves PodcastsPort X Logistics is your easy button for your drayage, transload, and trucking needs for all ports and ramps in the United States and Canada. Our four pillars of Culture, Service, Tech, and Trucks are what set us apart from the rest. We provide full visibility from the second your container leaves the origin port to the final stage of delivery.

On today's episode Dooner and The Dude are talking to Daniel “Mr. Supply Chain” Stanton about how the supply chain bullwhip effect has impacted freight this year. Will inventory overflows be the grinch that stole carriers Christmas?The second-largest cost for operating a truck is fuel (especially this year!) Chris Jones, EVP of industry and services at Descartes, shares how tech is helping to reduce this cost burden for carriers. Wars are won with logistics, so it is no surprise that this industry is a welcoming home to veterans. However, how can we better support our servicemen and women when they enter civilian life? Ivan Hernandez, owner at Vets2Trucking, shares how he is helping to get vets into the cab.Plus, DAT and Convoy's legal battle; outbound tender rejects fall below 6% for first time in 25 months; FMC considers congestion emergency order; sleeping CDL school instructors; and the true menace of bouncy castles.   Visit our sponsorWatch on YouTubeSubscribe to the WTT newsletterApple PodcastsSpotifyMore FreightWaves Podcasts

Daniel “Mr. Clutch” Mercado Castro te pone al día con el mejor resume de las Ligas Mayores (MLB).

Daniel “Mr. Clutch” Mercado Castro resume lo ocurrido en la MLB

Daniel “Mr. Clutch” Mercado Castro resume el acontecer semanal de la MLB

Daniel “Mr. Clutch” Mercado Castro analiza y resume el acontecer en la MLB

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo acontecido en la MLB

Daniel “Mr. Clutch” Mercado Castro nos resume qué pasó en el Draft de la NBA y la locura de la Agencia Libre

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en las NBA Finals 2022

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo ocurrido en la MLB 2022.

Daniel “Mr. Clutch” Mercado resume y analiza lo ocurrido en la MLB

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en las pasadas semanas 7 y 8 de la temporada de MLB 2022

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en las Finales de la Conferencia en la NBA.

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en las semifinales de la conferencia en la NBA.

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo ocurrido en las semanas 5 y 6 de la MLB

Daniel “Mr. Clutch “ Mercado Castro resume y analiza lo ocurrido en la 1era Ronda de los NBA Playoffs 2022

Daniel “Mr. Clutch” Mercado Castro resume y analiza la 4ta semana de la MLB 2022.

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en la semana 3 de la MLB

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en el Play In y los NBA Playoffs

Daniel “Mr. Clutch” Mercado Castro resume y analiza la 2da semana de la MLB 2022

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo mejor de la semana en la MLB.

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en la NBA

Daniel “Mr. Clutch” Mercado Castro analiza lo que sucedió en la 8va semana de la NBA 2021-2022

Daniel “Mr. Clutch” Mercado Castro resume y analiza lo ocurrido en la 7ma semana de la NBA 2020-2021

Daniel “Mr. Clutch” Mercado Castro analiza y resume las pasadas semanas en la NBA

Daniel “Mr. Clutch” Mercado Castro analiza lo ocurrido en la 4ta Semana en la NBA 2021-2022

Daniel “Mr. Clutch” Mercado analiza y resume la 2da semana de la NBA 2021-2022

Daniel “Mr.Clutch” Mercado Castro te analiza y resume lo que sucedió en la 1era semana de la NBA 2021-2022

Daniel “Mr. Clutch” Mercado analiza y resume lo sucedido en las Finales, Draft y cambios en la NBA 2021

Daniel “Mr. Clutch” Mercado Castro analiza y resume todo lo que nos lleva a la Final entre Suns vs Bucks

Daniel “Mr. Clutch” Mercado Castro te pone al día con lo ocurrido en la NBA Playoffs 2021

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido rumbo a los Playoffs de la NBA.

Daniel “Mr. Clutch” Mercado Castro analiza y resume lo sucedido en la semana 7 de la MLB