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Dr Glenn McConell chats with Professor Russell Hepple from the University of Florida, USA. He is an expert on muscle mitochondria. We tend to think of the mitochondria as the powerhouse of the cell. As Russ clearly explains there is a lot more going on than only this. It is very important that the inner mitochondrial membrane remains impermeable. However, there are situations such as aging, ischemia reperfusion injury, muscle dystrophies and perhaps cancer/chemotherapy where calcium and reactive oxygen species can build up and affect this permeability. This mitochondrial permeability transition is a major focus of Russell's research. Very interesting work and an informative chat. Russell does very well to simplify a complicated area of research. Twitter: @HeppleRuss0:00. Introduction1:50. The mitochondria beyond “the powerhouse”3:30. Free radicals/reactive oxygen species can be good4:50. ROS production at rest and during exercise7:50. Chronically elevation of ROS8:55. Inner mitochondrial membrane is impermeable10:30. Elevated calcium levels in the cell/mitochondria15:40. Mitochondrial permeability transition pore17:40. Swelling and rupture of mitochondria20:10. What causes the increase in calcium etc/aging23:40. Ischemia reperfusion injury during a heart attack26:00. Cyclophilin D, calcium and mitochondrial permeability transition28:30. Muscular dystrophy and mitochondrial permeability transition31:15. Interactions between calcium and ROS35:00. Diabetes and mitochondrial permeability transition37:00. Aging and mitochondrial function/volume (sex differences)42:35. Can calcium precipitate in the cell?43:53. Can assume skeletal muscle responds similarly to other cells47:00. Aging and mitochondrial permeability transition48:55. Aging and the neuromuscular junction51:58. Deinnervation and the muscle endplate54:58. Cancer and mitochondrial permeability transition57:35. Chemotherapy and mitochondrial permeability transition1:00:15. Takeaway messages1:01:49. Outro (9 seconds)Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise's effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: glenn.mcconell@gmail.comSubscribe to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice
Follow @thebuzzrnet Release Date: 06/01/23 Location: United Kingdom, Newcastle Upon Tyne Scott Hepple ‘Letting Go' About the Song Newcastle, UK based musician Scott Hepple is set to release his debut single ‘Letting Go' on January 6th 2023. Being accompanied by a super 8 montage/green screen style music video, the song is a fuzz-filled but heartfelt...
Wayne Hepple from the SES chats to Marnie and Campo about heavy rain and flash flooding battering the south east
WITH STORMS ON THE WAY MARNIE AND CAMPO CAUGHT UP WITH SES REGIONAL DIRECTOR WAYNE HEPPLE
New NHL Jerseys, Tampa Bay Lightning Cup Celebration, George Gwozdecky, Alan Hepple Conference Call, Elliotte Friedman on Corey Crawford and Avs Offseason
There are very few names in the international bar world that have been as influential over the years as Nick Strangeway. Whether it was resurrecting lost recipes, foraging for ingredients or innovating cocktails via molecular mixology, he has consistently managed to be at the forefront of the industry. Which is why we were so happy to sit down with him & hear him share his story & inspiration. Learn More: Nick Strangeway https://www.diffordsguide.com/people/3228/bartender/nick-strangeway Hepple Gin https://www.hepple-gin.com ============================== Join us every Monday as acclaimed bartender, Erick Castro, interviews some of the bar industry's top talents from around the world, including bartenders, distillers & authors. If you love cocktails & spirits then this award-winning podcast is just for you. FOLLOW US ON INSTAGRAM: Erick Castro: www.instagram.com/HungryBartender Bartender at Large: www.instagram.com/BartenderAtLarge FOLLOW US ON TWITTER: Erick Castro: www.twitter.com/HungryBartender Bartender at Large: www.twitter.com/BartendAtLarge
More gin and crime is on the menu, as we complete our look at highwaymen’s relationship with gin, comparing gin’s reputation in the 18th century with that of 1960s gangland London. We also have a masterclass from Hepple, and of course all the latest gin news.
Avalanche director of amateur scouting Alan Hepple previews the 2019 NHL Draft on the Avs Cast
Nick Strangeway kenne ich seit gut 15 Jahren. Früher hinter den Bars in London, dann als Berater für Spirituosen Brands und Lifestyle Firmen rund um den Globus. Er ist Wahnsinnig. Im Besten aller Sinne. Und das ist gut so. Er ist der letzte meiner HEPPLE FIVE Interview Runde. Während wir sprachen tranken wir Martinis an einer Steinbar in den Hügeln von Hepple, direkt neben den Wacholderbüschen.
Ich stehe in der Küche von Walter Landsitz in Hepple. Valentine kocht ein Menu für 20 Bartender und Freunde von Hepple. Planters Lunch. Heute gehts auf die Hügel von Hepple. Denn guter Wacholder brauch knapp 16 Jahre bis er brauchbar für die Ernte ist. Und Hepple Gin verwendet unter anderem grünen Wacholder. Frisch. Direkt vom Buch in die Vakuum Destille. Und Valentine Warner ist der Mann, der die Hepple Five zusammengebracht hat. Und er ist ein echter Foodie. Passionierter Koch. Ja sogar Fernsehkoch. Und er liebt gute Aromen. Und guten Gin.
Anfang April 2019 hat Tender-Spirits die Hepple Destilleie in Hepple besucht. Wir lieben diesen Gin. Weil er so unglaublioch gut Wachholder hervorbringt. Aber auch wegen der fünf Personen hinter diesem Gin. Vier von Ihnen konnte ich izum Interview gewinnen. Heute spreche ich mit dem "Landlord" von Hepple, oder besser dem Mutterboden. Und trinke um 11.00 Uhr früh einen Martini.
Avalanche director of amateur scouting Alan Hepple previews the 2018 NHL Draft on the latest Avs Cast
The family of our guest today views the world by what is edible and what is not edible. It’s not a shock that Valentine Warner would end up as one of the most well known chefs in the UK. Working hand in hand with Mother nature, Valentine’s first foray into the spirit would produced award winning Hepple Gin. Our Cocktail of the Week is the Hepple Martini. Ingredients 10 Parts Hepple Gin 1 Part Dry Vermouth Method Pour ingredients into a mixing glass filled with ice.Stir slowly 30 times. Strain into a chilled glass and garnish with a small twist of lemon peel. You’ll find this recipe and all the cocktails of the week on ALushLifeManual.com, where you’ll also find all the ingredients in our shop. Until next time… bottom’s up!
Your Avs Cast features a sitdown with Avalanche director of amatuer scouting Alan Hepple ahead of the 2017 NHL Draft.
Your Avs Cast features a sitdown with Avalanche director of amatuer scouting Alan Hepple ahead of the 2016 NHL Draft.
Between August 2007 and June 2008 Professor Hepple was interviewed three times, to record his reminiscences of his career, including his involvement with South Africa, and his long association with the Faculty of Law at the University of Cambridge. The interviewer is Lesley Dingle. These interviews were recorded and the audio version is available on this website with transcript of those recordings: - First Interview (21 August 2007): South Africa (1934-1963) - Second Interview (2 May 2008): Cambridge and UK (1963 - present) - Third Interview (13 June 2008): Professor Hepple's Published works For more information, see the Squire website at http://www.squire.law.cam.ac.uk/eminent_scholars/
Between August 2007 and June 2008 Professor Hepple was interviewed three times, to record his reminiscences of his career, including his involvement with South Africa, and his long association with the Faculty of Law at the University of Cambridge. The interviewer is Lesley Dingle. These interviews were recorded and the audio version is available on this website with transcript of those recordings: - First Interview (21 August 2007): South Africa (1934-1963) - Second Interview (2 May 2008): Cambridge and UK (1963 - present) - Third Interview (13 June 2008): Professor Hepple's Published works For more information, see the Squire website at http://www.squire.law.cam.ac.uk/eminent_scholars/
Between August 2007 and June 2008 Professor Hepple was interviewed three times, to record his reminiscences of his career, including his involvement with South Africa, and his long association with the Faculty of Law at the University of Cambridge. The interviewer is Lesley Dingle. These interviews were recorded and the audio version is available on this website with transcript of those recordings: - First Interview (21 August 2007): South Africa (1934-1963) - Second Interview (2 May 2008): Cambridge and UK (1963 - present) - Third Interview (13 June 2008): Professor Hepple's Published works For more information, see the Squire website at http://www.squire.law.cam.ac.uk/eminent_scholars/