Podcasts about muscular

Muscular dystrophy (MD) is a group of genetic diseases that affect about 16 to 25 per 100,000 people in the US, with the most common childhood form being Duchenne muscular dystrophy (DMD) and the most common adult form being myotonic dystrophy. The prevalence of DMD is estimated at around 1 in 3,500 live male births. Prenatal carrier screening for this is part of the ACMG Tier 3 expanded carrier panel. This is different from spinal muscular atrophy (SMA). As we recently had a patient who was a MD carrier, with affected male children, who we cared for, we decided to do a quick review of muscular dystrophy: its prevalence, genetics, and evaluation of asymptomatic maternal carriers.1. https://www.mda.org/disease/duchenne-muscular-dystrophy/causes-inheritance2.https://www.nichd.nih.gov/health/topics/musculardys/conditioninfo/causes3. https://www.nhs.uk/conditions/muscular-dystrophy/4. ACMG: https://thednaexchange.com/2022/03/30/acmg-carrier-screening-guideline-the-hypothetical-tier-3-panel/#:~:text=The%20goal%20of%20this%20ACMG,1%20in%2040%2C000%20or%20higher.

Episode 1839 - brought to you by our incredible sponsors: RIDGE - Take advantage of Ridge's Biggest Sale of the Year and GET UP TO 47% Off by going to ⁠https://www.Ridge.com/HARDFACTOR⁠ #Ridgepod DaftKings - Download the DraftKings Casino app, sign up with code HARDFACTOR, and spin your favorite slots! The Crown is Yours - Gambling problem? Call one eight hundred GAMBLER Timestamps: (00:01:52) - What happened in 1840, because Wes fucked up the date  (00:02:55) - What to see, and what not to see, in theaters right now (00:05:25) - New information about Trump Assassin wannabe, Thomas Crooks, and what his fetishes were (00:26:20) - Restaurant owners are battling a surge in online scammers who want their money back from take-out orders (00:35:15) - The Icelandic language is on its way out and will soon be extinct (00:38:20) - Beloved rest stop Buc-ee's is suing an underwear company, “Nuthuggers,” for copyright infringement because they too have a rodent as a logo Thank you for listening!! Go to patreon.com/hardfactor to join our community, get access to bonus pods, discord chat, and trivia with the hosts on Friday 12/12 - but most importantly: HAGFD Learn more about your ad choices. Visit megaphone.fm/adchoices

Are squirrels more muscular than we realize? Daryn recaps joining Kathy Hilton's pajama party! Head over the ShakenAndDisturbed.com for new merchandise, blogs for our episodes, YouTube videos, and Patreon! Watch and listen to this and every other episode several days early on Patreon! Patreon members can join us during our live recordings, comment on the case, participate in polls and get shout outs! Join for as little as $5 a month right here! Follow John on Twitter @jthrasher, Instagram @jthrasher and TikTok @johnthrasher Follow Daryn on Twitter @CarpeDaryn and Instagram @CarpeDaryn

Allie interviews Nick Freitas, ex-Green Beret and Virginia delegate, to unpack biblical masculinity's crisis in the church and in culture. He exposes weak leadership, urges men to reclaim strength through Christ, and shares about raising sons and daughters using scripture's wisdom. He also explains the difference between Andrew Tate and the manosphere versus true, Christian masculinity. Join us to revive godly manhood, disciple boldly, and honor God's design in family and faith. Buy Allie's book "Toxic Empathy: How Progressives Exploit Christian Compassion": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.toxicempathy.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ --- Timecodes: Pre-Born — Will you help rescue babies' lives? Donate by calling #250 & say keyword 'BABY' or go to ⁠⁠⁠⁠Preborn.com/ALLIE⁠⁠⁠⁠. Seven Weeks Coffee — Experience the best coffee while supporting the pro-life movement with Seven Weeks Coffee; use code ALLIE at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.sevenweekscoffee.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to save up to 25% off your first order, plus your free gift! --- Buy Allie's book "You're Not Enough (& That's Okay): Escaping the Toxic Culture of Self-Love": ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://alliebethstuckey.com/book⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠   Relatable merchandise – use promo code "ALLIE10" for a discount: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://shop.blazemedia.com/collections/allie-stuckey⁠⁠⁠ (0:00) Intro(4:04) Christian Masculinity(8:19) Why Men Follow Andrew Tate(16:51) Meekness vs Weakness(22:21) Christian Fatherhood(31:33) Raising Sons vs Raising Daughters(40:20) The Price of Running for Office---Today's SponsorsSend a taste of home this holiday season with Keksi — soft, thick, handcrafted cookies made with the best ingredients. Keksi ships nationwide! Order yours at keksi.com with code ALLIE15 for 15% off.Good Ranchers — Go to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠GoodRanchers.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and subscribe to any box (but preferably the Allie Beth Stuckey Box) to get free Wagyu burgers, hot dogs, bacon, or chicken wings in every box for life. Plus, you'll get $40 off when you use code ALLIE at checkout.A'del — Try A'del's hand-crafted, artisan, small-batch cosmetics and use promo code ALLIE 25% off your first time purchase at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://⁠⁠⁠⁠AdelNaturalCosmetics.com⁠⁠NetSuite — Gain visibility and control of your financials, planning, budgeting, and inventory so you can manage risk, get reliable forecasts, and improve margins. Go to ⁠ NetSuite.com/ALLIE⁠⁠ to get the CFO's guide to AI and Machine Learning. Learn more about your ad choices. Visit megaphone.fm/adchoices

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In this episode we finally got to discuss our reactions to one of the craziest races we have ever seen in Ironman history: the all-women's 2025 Ironman World Championships in Kailua-Kona, Hawaii. We discuss what it means to win and lose with grace, Taylor Knibb's incredible post-race interview, the role of heat and humidity in making or breaking an athlete's day, and what bike brands seem to be most popular at the elite level. We also chat through the role of muscular endurance in super long-distance events like half and full Ironmans, marathons, and ultra runs, and preview some of the innovations we will be bringing to our athletes' training in the 2026 season to account for this. Next, we deep dive on takeaways from Ironman California, which Katie and Jim agree is one of the best races you can do as a first-time IM athlete. Finally, we expand on a listener question from last week about burnout and drill into three different types of athletes: “event athletes,” “identity-based athletes,” and “for the love of the sport athletes,” considering what lessons we can learn from each athlete type as we try to burnout-proof our season. This episode was so fun to record and we're excited to share it with you, so check it out!To view extended show notes for this episode, visit: theendurancedrive.com/podcast To share feedback or ask questions to be featured on a future episode, please use ⁠this form⁠ or email: Katie@TheEnduranceDrive.com.

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Limb-girdle muscular dystrophies (LGMDs) encompass a group of genetically heterogeneous skeletal muscle disorders. There has been an explosion of newly identified LGMD subtypes in the past decade, and results from preclinical studies and early-stage clinical trials of genetic therapies are promising for future disease-specific treatments. In this episode, Gordon Smith, MD, FAAN, speaks with Teerin Liewluck, MD, FAAN, FANA, author of the article “Limb-Girdle Muscular Dystrophies” in the Continuum® October 2025 Muscle and Neuromuscular Junction Disorders issue. Dr. Smith is a Continuum® Audio interviewer and a professor and chair of neurology at Kenneth and Dianne Wright Distinguished Chair in Clinical and Translational Research at Virginia Commonwealth University in Richmond, Virginia. Dr. Liewluck is a professor of neurology at the Division of Neuromuscular Medicine and Muscle Pathology Laboratory at Mayo Clinic College of Medicine in Rochester, Minnesota. Additional Resources Read the article: Limb-Girdle Muscular Dystrophies Subscribe to Continuum®: shop.lww.com/Continuum Earn CME (available only to AAN members): continpub.com/AudioCME Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @gordonsmithMD Guest: @TLiewluck Full episode transcript available here Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about earning CME, subscribing to the journal, and exclusive access to interviews not featured on the podcast. Dr Smith: This is Dr Gordon Smith with Continuum Audio. Today I'm interviewing Dr Teerin Liewluck, a good friend of mine at the Mayo Clinic, about his article on the limb girdle muscular dystrophies. This article appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders, a topic that is near and dear to my heart. Teerin, welcome to the podcast, and maybe you can introduce yourself to our listeners. Dr Liewluck: Thank you very much, Gordon, and I want to say hi to all the Continuum fans. So, I'm Dr Teerin Liewluck, I'm the professor of neurology at Mayo Clinic in Rochester, Minnesota. So, my practice focus on all aspects of muscle diseases, both acquired and genetic myopathies. Glad to be here. Dr Smith: I just had the great pleasure of seeing you at a seminar in Houston where you talked about this topic. And so, I'm really primed for this conversation, which I'm very excited about. I find this topic a little hard, and I'm hoping I can learn more from you. And I wonder if, as we get started, recognizing many of our listeners are not in practices focused purely on muscle disease, maybe you can provide some context about why this is important for folks doing general neurology or even general neuromuscular medicine? Why do they need to know about this? Dr Liewluck: Yes, certainly. So, I would say limb girdle muscular dystrophy probably the most complex category of subgroup of muscle diseases because, by itself, it includes thirty-four different subtypes, and the number's still expanding. So, each subtype is very rare. But if you group together, it really have significant number of patients, and these patients present with proximal weakness, very high CK, and these are common patients that can show up in the neurology clinic. So, I think it's very important even for general neurologists to pick up what subtle clues that may lead to the diagnosis because if we are able to provide correct diagnosis for the patients, that's very important for patient management. Dr Smith: So, I wonder if maybe we can talk a little bit about the phenotype, Terran. I mean, your article does a great job of going over the great diversity. And you know, I think many of us here, you know, limb girdle muscular dystrophy and we think of limb girdle weakness, but the phenotypic spectrum is bananas, right? Rhabdomyolysis, limb girdle distal myopathy. I mean, when should our listeners suspect LGMD? Dr Liewluck: Yes, I think by the definition to all the LGMD patients will have limb girdle of proximal weakness and very high CK. So, these are common phenotypes among thirty-four different subtypes. But if it did take into details, they have some subtle differences. In the article, what I try to simplify all these different subtypes that we can categorize at least half of them into three main group that each group the underlying defect sharing among those subtypes and also translate into similar muscles and extra muscular manifestations. You will learn that some of the limb girdle muscular dystrophy may present with rhabdomyolysis. And we typically think of this as metabolic myopathies. But if you have a rhabdomyolysis patient, the CK remain elevated even after the acute episode, that's the key that we need to think this could be LGMD. That's for an example. Dr Smith: So, I wonder if maybe we can start there. I was going to go in a different direction, but this is a good transition. It's easy to see the opportunity to get confused between LGMD or, in that case, a metabolic myopathy or other acquired myopathies. And I think particularly adult neurologists are more accustomed to seeing acquired muscle disease. Are there particular clues that, or pearls that adult neurologists seeing patients with muscle disease can use to recognize when they should be thinking about LGMD given the diverse phenotype? Dr Liewluck: Yes. What I always tell the patient is that there are more than a hundred different types of muscle diseases, but we can easily divide into groups: acquired and genetic or hereditary. So, the acquired disease is when you encounter the patients who present with acute or subacute cause of the weakness, relatively rapidly progressive. But on the opposite, if you encounter the patient who present with a much more slowly progressive cause of weakness over several months or years, you may need to think about genetic disease of the muscle with also including limb-girdle muscular dystrophy. The detailed exam to be able to distinguish between each type of muscular dystrophy. For example, if proximal weakness, certainly limb girdle muscular dystrophy. If a patient has facial weakness, scapular winking, so you would think about facial scapular hematoma dystrophy. So, the slowly progressive cause of weakness, proximal pattern of weakness, CK elevation, should be the point when you think about LGMD. Dr Smith: So, I have a question about diagnostic evaluation. I had a meeting with one of my colleagues, Qihua Fan, who's a great peripheral nerve expert, who also does neuromuscular pathology. And we were talking about how the pathology field has changed so much over the last ten years, and we're doing obviously fewer muscle biopsies. Our way of diagnosing them has changed a lot with the evolution of genetic testing. What's your diagnostic approach? Do you go right to genetic testing? Do you do targeted testing based on phenotype? What words of wisdom do you have there? Dr Liewluck: Yes, so, I mean, being a muscle pathologist myself, it is fair to say that the utility of muscle biopsies when you encounter a patient with suspects that limb girdle muscular dystrophy have reduced over the year. For example, we used to have like fifteen, seventeen hundred muscle biopsies a year; now we do only thirteen hundred biopsies a year. Yes, as you pointed out, the first step in my practice if I suspect LGMD is to go with genetic testing. And I would prefer the last gene panel that not only include the LGMD, but also include all other genetic muscle disease as well as the conjunctive myopic syndrome, because the phenotype can be somehow difficult to distinguish in certain patients. Dr Smith: So, do you ever get a muscle biopsy, Teerin? I mean you obviously do; only thirteen hundred. Holy cow, that's a lot. So, let me reframe my question. When do you get a muscle biopsy in these patients? Dr Liewluck: Muscle biopsy still is present in LGMD patients, it's just we don't use it at the first-tier diagnostic test anymore. So, we typically do it in selected cases after the genetic testing in those that came back inconclusive. As you know, you may run into the variant of unknown significance. You may use the muscle biopsy to see, is there any histopathology or abnormal protein Western blot that may further support the heterogenicity of the VUS. So, we still do it, but it typically comes after genetic testing and only in the selected cases that have inconclusive results or negative genetic testing. Dr Smith: I'd like to ask a question regarding serologic testing for autoantibodies. I refer to a really great case in your article. There are several of them, but this is a patient, a FKRP patient, who was originally thought to have dermatomyositis based on a low-titer ME2 antibody. You guys figured out the correct diagnosis. We send a lot of antibody panels out. Wonder if you have any wisdom, pearls, pitfalls, for how to interpret antibody tests in patients with chronic myopathies? We send a lot of them. And that's the sort of population where we need to be thinking about limb-girdle muscular dystrophies. It's a great case for those, which I hope is everyone who read your article in detail. What do you have to say about that? Dr Liewluck: Yes, so myositis antibodies, we already revolutionized a few of muscle diseases. I recall when I finished my fellowship thirteen years ago, so we don't really have much muscle myositis antibodies to check. But now the panel is expanded. But again, the antibodies alone cannot lead to diagnosis. You need to go back to your clinical. You need to make sure the clinical antibodies findings are matched. For example, if the key that- if the myocytes specific antibodies present only at the low positive title, it's more often to be false positive. So, you need to look carefully back in the patient, the group of phenotypes, and when in doubt we need to do muscle biopsies. Now on the opposite end, the other group of the antibody is the one for necrotizing autoimmune myopathy; or, the other name, immune-mediated necrotizing myopathy. This is the new group that we have learned only just recently that some patients may present as a typical presentation. I mean, when even thinking about the whole testing autoimmune myopathy, we think about those that present with some acute rapidly progressive weakness, maybe has history of sudden exposures. But we have some patients that present with very slowly progressive weakness like muscular dystrophies. So now in my practice, if I encounter a patient I suspect LGMD, in addition to doing genetic testing for LGMD, I also test for necrotizing doing with myopathy antibodies at the same time. And we typically get antibody back within what, a week or two, but projected testing would take a few months. Dr Smith: Yeah. And I guess maybe you could talk a little bit about pitfalls and interpretation of genetic tests, right? I think you have another case in your article, and I've certainly seen this, where a patient is misdiagnosed as having a genetic myopathy, LGMD, based on, let's say, just a misinterpretation of the genetic testing, right? So, I think we need to think of it on both sides. And I like the fact that the clinical aspects of diagnosis really are first and foremost most important. But maybe you can talk about wisdom in terms of interpretation of the genetic panel?  Dr Liewluck:Yes. So genetic testing, I think, is a complex issue, particularly for interpretation. And if you're not familiar with this, it's probably best to have your colleagues in genetics that help looking at this together. So, I think the common scenario we encounter is that in those dystrophies that are autosomal recessive, so we expect that the patient needs to have two abnormal copies of the genes to cause the disease. And if patients have only one abnormal copy, they are just a carrier. And commonly we see patients refer to us as much as dystrophy is by having only one abnormal copy. If they are a carrier, they should not have the weakness from that gene abnormality. So, this would be the principle that we really need to adhere. And if you run into those cases, then maybe you need to broaden your differential diagnosis. Dr Smith: I want to go back to the clinical phenomenology, and I've got a admission to make to you, Teerin. And I find it really hard to keep track of these disorders at, you know, thirty-four and climbing a lot of overlap, and it's hard to remember them. And I'm glad that I'm now going to have a Continuum article I can go to and look at the really great tables to sort things out. I'm curious whether you have all these top of mind? Do you have to look at the table too? And how should people who are seeing these patients organize their thoughts about it? I mean, is it important that you memorize all thirty-four plus disorders? How can you group them? What's your overall approach to that? Dr Liewluck: I need to admit that I've not memorize all twenty-four different subtypes, but I think what I triy to do even in my real-life practice is group it all together if you can. For example, I think that the biggest group of these LGMD is what we call alpha-dystroglycanopathies. So, this include already ten different subtypes of recessive LGMD. So alpha-dystroglycan is the core of the dystrophin-associated glycoprotein complex. And it's heavy glycosylated protein. So, the effect in ten different genes can affect the glycosylation or the process of adding sugar chain to this alpha-dystroglycan. And they have similar features in terms of the phenotype. They present with proximal weakness, calf pseudohypertrophy, very high CK, some may have recurrent rhabdomyolysis, and cardiac and rhythmic involvement are very common. This is one major group. Now the second group is the limb-girdle muscular dystrophy due to defective membrane repair, which includes two subtypes is the different and on dopamine five. The common feature in this group is that the weakness can be asymmetric and despite proximal weakness, they can have calf atrophy. On muscle biopsy sometimes you can see a myeloid on the muscle tissues. And the third group is the sarcoglycanopathy, which includes four different subtypes, and the presentation can look like we share. For the rest, sometimes go back to the table. Dr Smith: Thank you for that. And it prompts another question that I always wonder about. Do you have any theories about why such variability in the muscle groups that are involved? I mean, you just brought up dystroglycanopathy, for instance, as something that can cause a very distal predominant myopathy; others do not. Do we at this point now have an understanding given the better genetics that we have on this and work going on in therapeutic development, which I want to get to in a minute, that provides any insight why certain muscle groups are more affected? Dr Liewluck: Very good question, Gordon. And I would say the first question that led me interested in muscle disease---and this happened probably back in 2000 when I just finished medical school---is why, why, why? Why does muscle disease tend to affect proximal muscles? I thought by now, twenty-five years later, we'd have the answer. I don't. I think this, you don't know clearly why muscle diseases, some affect proximal, some affect distal. But the hypothesis is, and probably my personal hypothesis is, that maybe certain proteins may express more in certain muscles and that may affect different phenotypes. But, I mean, dysferlin has very good examples that can confuse us because some patients present with distal weakness, some patients present with proximal weakness, that's by the same gene defect. And in this patient, when we look at the MRI in detail, actually the patterns of fatty replacements in muscle are the same. Even patient who present clinically as a proximal or distal weakness, the imaging studies show the same finding. Bottom line, we don't know. Dr Smith: Yeah, who knew it could be so complex? Teerin, you brought up a really great point that I wanted to ask about, which is muscle MRI scan, right? We're now seeing studies that are doing very broad MR imaging. Do you use some muscle MRI very frequently in your clinical evaluation of these patients? And if so, how? Dr Liewluck: Maybe I don't use it as much as I could, but the most common scenario I use in this setting is when I have the genetic testing come back with the VUS. So, we look at each VUS, each gene in detail. And if anything is suspicious, what I do typically go back to the literature to see if that gene defect in particular has any common pattern of muscle involvement on the MRI. And if there is, I use MRI as one of the two to try to see if I can escalate the pathogenicity of that VUS. Dr Smith: And a VUS is a “Variant of Unknown Significance,” for our listeners. I'm proud that I remember that as a geneticist. These are exciting times in neurology in general, but particularly in an inherited muscle disease. And we're seeing a lot of therapeutic development, a lot going on in Duchenne now. What's the latest in terms of disease-modifying therapeutics and gene therapies in LGMD? Dr Liewluck: Yes. So, there are several precritical and early-phase critical trials for gene therapy for the common lymphoma of muscular dystrophies. For example, the sarcoglycanopathies, and they also have some biochemical therapy that arepossible for the LGMD to FKRP. But there are many things that I expect probably will come into the picture broader or later phase of critical tryouts, and hopefully we have something to offer for the patients similar to patients with Duchenne muscular dystrophy. Dr Smith: What haven't we talked about, I mean, holy cow? There's so much in your article. What's one thing we haven't talked about that our listeners need to hear? Dr Liewluck: Good questions. So, I think we covered all, but often we get patients with proximal weakness and high CK, and they all got labeled as having limb-girdlemuscular dystrophy. What I want to stress is that proximal weakness and high CK is a common feature for muscle diseases, so they need to think broad, need to think about all possibilities. Particularly don't want to miss something treatable. Chronic, slowly progressive cause, as I mentioned earlier, we think more about muscle dystrophy, but at the cranial range, we know that rare patients with necrotic autonomyopathy and present with limb good of weakness at a slowly progressive cost. So, make sure you think about these two when suspecting that LGMD patient diabetic testing has come back inconclusive. Dr Smith: Well, that's very helpful. And fortunately, there's several other articles in this issue of Continuum that help people think through this issue more broadly. Teerin, you certainly don't disappoint. I enjoyed listening to you about a month ago, and I enjoyed reading your article a great deal and enjoy talking to you even more. Thank you very much. Dr Liewluck: Thank you very much, Gordon. Dr Smith: Again, today I've been interviewing Dr Teerin Liewluck about his article on limb-girdle muscular dystrophy, which appears in the October 2025 Continuum issue on muscle and neuromuscular junction disorders. Please be sure to check out Continuum Audio episodes for this and other issues. And thanks to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. AAN members, you can get CME for listening to this interview by completing the evaluation at continpub.com/audioCME. Thank you for listening to Continuum Audio.

O cancro é uma doença multifatorial, influenciada por inúmeros determinantes sociais, de saúde e ambientais que muitas vezes escapam ao nosso controlo. Ainda assim, os estilos de vida que adotamos antes, durante e após um diagnóstico podem ser determinantes. O importante é perceber como integrar essa informação nas nossas rotinas da melhor forma possível. Sem pressões e sem culpa, porque nunca depende só de nós. O terceiro episódio desta série que assinala o mês da luta contra o cancro da mama e que conta com o apoio dos Cereais Fitness, é sobre o papel que o exercício físico e a nutrição podem assumir no tratamento e prevenção da doença. Margarida Santos convida Inês Correia, fisiologista do exercício e investigadora na Faculdade de Motricidade Humana, e Marta Carriço, nutricionista dedicada à área da oncologia. “O consumo excessivo de produtos ultraprocessados como refrigerantes e fast-food está associado ao excesso de gordura corporal e o excesso de gordura corporal é um risco marcado para doença oncológica, como o tabaco”, concordam as especialistas. Vamos a mais uma ‘Consulta Aberta’?See omnystudio.com/listener for privacy information.

⁠Assessoria esportiva online e cursos⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠E-book "Dieta Inteligente - Para Perder Gordura e Ganhar Massa Muscular" – só R$ 39,90⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Curso de Treino – Monte seu próprio treino ainda hoje⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Curso de Emagrecimento – Como emagrecer e nunca mais engordar ⁠⁠⁠⁠⁠⁠| ⁠⁠⁠⁠⁠⁠Curso Sobre Esteroides Anabolizantes – Não use esteroides antes de fazer este curso ⁠⁠⁠⁠⁠⁠| ⁠⁠⁠⁠⁠⁠Curso de Suplementação para Praticantes de Musculação⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Grupo do Telegram com promoções⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Growth⁠⁠⁠⁠⁠⁠ | ⁠⁠⁠⁠⁠⁠Oficialfarma⁠

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy's disease, is a rare, progressive neuromuscular disorder that is often misdiagnosed and diagnosed late. A new CMAJ guideline offers Canadian-specific recommendations for its recognition and management.On this episode we hear from Richard Paul, a former bus driver from Saskatoon, who recalls how his symptoms began suddenly with an inability to bite into a sandwich and, over the years, progressed so gradually he barely noticed the loss of strength. His experience captures both the slow, inexorable progression of SBMA and the uncertainty of living without a diagnosis for decades.Mr. Paul was finally diagnosed by Dr. Kerri Schellenberg, a neuromuscular neurologist at the University of Saskatchewan and lead author of the guideline. She explains the clinical hallmarks of SBMA, its overlap with conditions such as ALS, and the non-motor manifestations that require attention. She also discusses the higher prevalence among Indigenous populations in Canada and how her team worked with a community Guiding Circle to ensure the recommendations reflect culturally appropriate care.For physicians, the guideline provides practical direction to support earlier recognition, timely referral, and multidisciplinary management. While there is no cure, coordinated care can significantly improve quality of life for people living with SBMA.For more information from our sponsor, go to md.ca/md-differenceComments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

EP. 231:  On this episode we're digging into one of the most exciting frontiers in cellular medicine: how Urolithin A, a powerful compound, supports mitochondrial health and slows the effects of aging at the cellular level. If you've been feeling low energy, dealing with inflammation, or noticing your strength and resilience aren't what they used to be, this episode is packed with science-backed insights to help recharge your body from the inside out. My guest today is Dr. Brad Currier, PhD, Manager of Clinical Trials at Timeline, who's leading the way in Urolithin A research. We're talking muscle metabolism, brain health, immunity, and how this prebiotic compound could be a total game changer for longevity and overall vitality. → Head to timeline.com/DRTYNA to get started & Use code DRTYNA at checkout to receive 20% off today!  Topics Discussed: → What is Urolithin A and how does it help mitochondria? → How does Urolithin A support muscle and metabolism? → How are postbiotics, gut health, and GLP-1s connected? → What does Mitopure research show for immunity and brain health? → How can you use Timeline's Urolithin A daily? Sponsored By: →  Head to timeline.com/DRTYNA to get started & Use code DRTYNA at checkout to receive 20% off today!  On This Episode We Cover:  → 00:00:00 - Introduction  → 00:01:19 - Understanding Urolithin A  → 00:05:24 - Mitochondrial health  → 00:09:08 - Mitochondrial lifecycle  → 00:11:08 - Muscular growth & health  → 00:14:21 - Mitopure research  → 00:17:50 - Postbiotics & the gut microbiome  → 00:22:14 - GLP1s & the gut  → 00:26:31 - Gut rehabilitation  → 00:28:03 - Aging  → 00:31:26 - High protein diets & strength training  → 00:34:45 - Aging + muscle strength  → 00:39:34 - Mitopure, HRT, + stacking  → 00:46:21 - Skincare + topicals  → 00:49:25 - Immune health + inflammation → 00:52:37 - Summary  → 00:56:27 - Trying Timeline!  Show Links:  → Dr. Tyna's Strength Corner Further Listening:  → EP. 196 | The Answer Is The Gym | Quick + Dirty → Strength Training Playlist  Check Out Timeline →  Head to timeline.com/DRTYNA to get started & Use code DRTYNA at checkout to receive 20% off today!  Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Conheça posturas estáticas que devem ser mantidas por pelo menos 30 segundos — e podem ser realizadas em casa sem equipamentos.

Callen wants a donkey real bad and talks hanging with George St. Pierre and Gordon Ryan at The Comedy Mothership, owning dogs, dog "lovers", Saddam Hussein stories, current events around the world including Khabib Nurmagomedov turning down an offer to fight Floyd Mayweather, Donald Trump's alleged 50th birthday note to Jeffrey Epstein, a body found in artist D4vd's Tesla, Get this episode and all future episodes AD FREE + 2 extended episodes, Fan Questions, exclusive behind the scenes content and more each month at https://www.patreon.com/tfatkO'Reilly Auto Parts - https://oreillyauto.com/FIGHTERMagic Mind - https://magicmind.com/True Classic - True Classic - Upgrade your wardrobe and save on @trueclassic at https://trueclassic.com/fighter ! #trueclassicpodSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode breaks down the importance of strength training and essential strength training tips for maximum performance. Learn why strength training matters for overall health and athletic performance, and the key principles to train effectively. Whether you're a beginner or an experienced lifter, this episode provides actionable advice backed by science to help you train smarter, build strength, and enjoy the process.@melissa_kendterResources Mentioned:Schoenfeld, B. J. (2010). The mechanisms of muscle hypertrophy and their application to resistance training. Journal of Strength and Conditioning Research, 24(10), 2857–2872. Rhea, M. R., et al. (2002). A comparison of linear and daily undulating periodized programs with equated volume and intensity for strength. Journal of Strength and Conditioning Research, 16(2), 250–255. Schoenfeld, B. J. (2017). Resistance training: Muscular adaptation and performance outcomes. Strength and Conditioning Journal, 39(2), 10–19. Bernárdez-Vázquez, R., et al. (2022). Resistance training variables for optimization of muscle hypertrophy. Frontiers in Sports, 3, 949021. Schoenfeld, B. J., et al. (2022). Less time, same gains: Comparison of superset vs traditional set training on muscular adaptations. Journal of Strength and Conditioning Research, 36(6), 1567–1574. Iversen, V. M., et al. (2021). No time to lift? Designing time-efficient training programs for strength and conditioning. Sports Medicine, 51(12), 2651–2663. 

CONHEÇA OS PRODUTOS DA CAFFEINE ARMY - KOALA: https://r.vocemaisrico.com/e08eeca18a Conheça os produtos da Puravida - cupom: SOCIOSPURAVIDA: https://r.vocemaisrico.com/ccb634b5a3 O sonho de quase todo praticante de atividade física é o mesmo: ganhar massa muscular e perder gordura ao mesmo tempo. Mas, se esse é o desejo da maioria, por que tão poucos conquistam esse resultado?A verdade é que, apesar de todos os modismos — dietas da moda, suplementos milagrosos e até mesmo o uso indiscriminado de hormônios —, o que realmente funciona continua sendo o básico: treino consistente, alimentação equilibrada, descanso de qualidade e disciplina.Será que o sono influencia mesmo na performance e no ganho de massa? O que pesa mais: treino ou dieta? Até onde vale a pena copiar a rotina de um fisiculturista? O cárdio atrapalha ou ajuda no crescimento muscular? Vale a estratégia de engordar para depois secar? E como começar do zero sem cair em atalhos e promessas milagrosas?Para responder a estas e outras perguntas, convidamos Renato Cariani e Júlio Balestrin para o episódio 238 do podcast Os Sócios.Se você quer entender como treino, descanso e disciplina se conectam para transformar seu corpo de forma consistente, este episódio vai te mostrar o caminho. Hosts: Bruno Perini @bruno_perini e Malu Perini @maluperiniConvidados: Renato Cariani @renato_cariani e Júlio Balestrin @juliobalestrinoficial

In this episode, you'll learn how movement directly influences your metabolism, immune system, brain function, and even the diversity of your gut microbiome. Dr. Kharrazian explains the critical role of messenger proteins released during physical activity, why maintaining muscle mass and bone density is key to longevity, and how inflammation can undermine your body's ability to recover.For patient-oriented functional medicine courses, visit https://drknews.com/online-courses/For practitioner functional medicine certification courses, visit https://kharrazianinstitute.com/For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/00:00 Introduction to the Podcast00:30 How Physical Movement Impacts Health01:54 Bone Volume, Osteopenia, and Health Consequences02:56 Toxic Chemicals, Bone Loss, and Aging03:50 Muscle Mass, Sarcopenia, and Mortality04:38 Movement, Depression, and Brain Chemistry05:15 Movement, Myokines, and Immune Function05:59 Microbiome Diversity, Gut Health, and Inactivity06:32 Overtraining Syndrome and its Red Flags07:11 Exercise, Mitochondrial Health, and Chronic Disease07:49 Movement & Brain Health: Repair, Mood, and Cognitive Disorders08:25 Sedentary Lifestyle in Children & Sarcopenia Risks09:45 Medical Management of Osteoporosis and Arthritis10:55 Inflammation, Muscular and Skeletal Degeneration12:16 Body Fat, Skinny Fat, and Inflammation12:46 Insulin Surges and Systemic Inflammation13:31 Microbiome, Leaky Gut, and Chronic Inflammatory Disease16:04 Food, Environmental Toxins, and Inflammation18:09 Protein Intake and Recovery from Chronic Disease19:12 Sleep, Sleep Apnea, and Bone Health19:57 Regenerative Medicine Therapies21:34 Conclusion and Podcast ResourcesSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

⁠Assessoria esportiva online e cursos⁠⁠⁠⁠ | ⁠⁠⁠⁠E-book "Dieta Inteligente - Para Perder Gordura e Ganhar Massa Muscular" – só R$ 39,90⁠⁠⁠⁠ | ⁠⁠⁠⁠Curso de Treino – Monte seu próprio treino ainda hoje⁠⁠⁠⁠ | ⁠⁠⁠⁠Curso de Emagrecimento – Como emagrecer e nunca mais engordar ⁠⁠⁠⁠| ⁠⁠⁠⁠Curso Sobre Esteroides Anabolizantes – Não use esteroides antes de fazer este curso ⁠⁠⁠⁠| ⁠⁠⁠⁠Curso de Suplementação para Praticantes de Musculação⁠⁠⁠⁠ | ⁠⁠⁠⁠Grupo do Telegram com promoções⁠⁠⁠⁠ | ⁠⁠⁠⁠Instagram⁠⁠⁠⁠ | ⁠⁠⁠⁠Facebook⁠⁠⁠⁠ | ⁠⁠⁠⁠Growth⁠⁠⁠⁠ | ⁠⁠⁠⁠Oficialfarma⁠

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]

On this episode of the Flex Diet Podcast, I chat with Dr. Mike Roberts, a full professor at Auburn University and head of the Nutri Bolt Applied and Molecular Physiology Lab. Mike's one of the sharpest minds in muscle science, and we go deep into the nitty-gritty of hypertrophy, including everything from rodent studies to human trials to the molecular pathways that drive muscle growth.We get into some serious geekery: ribosome biogenesis, muscle stem cells, the extracellular matrix — yeah, all the stuff happening behind the scenes when you train. Mike also shares his take on how HIIT and consistent resistance training impact muscle adaptation, and we riff on where nutrition fits into the equation.If you're into the science of muscle or you're a coach looking to better understand the mechanisms behind hypertrophy, you'll dig this one. Tons of actionable nuggets and some fascinating research.Check it out!Sponsors:Tecton Life Ketone drink! https://tectonlife.com/ DRMIKE to save 20%LMNT electrolyte drink mix: miketnelsonlmnt.comBeyond Power Voltra 1: https://www.beyond-power.com/?sca_ref=9191675.802mkRdulvAvailable now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:05:53 Dr. Mike Roberts' Academic Journey07:21 Research Focus: Muscle Physiology and Aging21:04 Innovative Research Projects and Findings43:03 Exploring Pyro Sequencing and Methylation45:17 Genetic Potential and Resistance Training46:16 Extreme Responders and Genetic Research47:21 Conference on Response Heterogeneity50:16 Ribosome Biogenesis and Muscle Stem Cells54:47 Extracellular Matrix and Hypertrophy01:03:04 Eccentric Training and Muscle Growth01:07:17 Practical Tips for Muscle Hypertrophy01:16:58 Conclusion and Final ThoughtsFlex Diet Podcast Episodes You May Enjoy:Episode 161: Muscle hypertrophy, exercise selection, and nutrient timing, an interview with Dr Chester Soko - https://youtu.be/0snSfWTuVYQ Episode 328: Grit Gains: Building Mental Toughness and Resilience in Training with Ben Mayfield Smith - https://youtu.be/Kg77mu1MAIkConnect with Mike:X: https://x.com/DrMikeRobertsGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

In this episode of HSS Presents, pediatric orthopedic surgeon Dr. Shevaun Doyle is joined by pediatric physical therapist Dr. Magdalena Oledzka to explore congenital muscular torticollis (CMT)—a common condition in infants that, if left untreated, can lead to head tilting, facial asymmetry, and developmental delays. They discuss the early signs and causes of CMT, emphasize the importance of timely intervention, and share practical physical therapy strategies. The conversation also covers how to support families with home-based routines, when to consider further evaluation or surgical referral, and long-term outcomes. Listeners will gain valuable insights into the collaborative, multidisciplinary approach to managing CMT from infancy through early childhood. This episode is essential listening for pediatric providers, therapists, and parents alike.

Join in with this prayer to a muscular Saviour, a King who leads the charge and takes the victory, handing it over to his people...

In this eye-opening and deeply informative episode, Dr. Vignesh Devraj sits down with fertility and relationship coach Sidanta to explore a long-overlooked aspect of conception: male reproductive health. From sperm quality and lifestyle choices to emotional intimacy, this conversation takes a bold, compassionate dive into the male contribution to fertility. The episode also shines a light on the role of a holistic, psychologically aware approach to conception. If you're navigating fertility challenges or looking to prepare consciously for parenthood, this episode offers not just Ayurvedic insight but also practical, science-backed tools and deep emotional intelligence.To receive a free summary of this episode, sign up at vigneshdevraj.comEpisode Highlights: Underrated role of male fertility for fetal healthTop lifestyle contributors to poor sperm qualityCelibacy practices to improve sperm healthAyurvedic Panchakarma for male infertilityRethinking health: Muscular doesn't mean fertileTimestamps:00:00 – 04:00: Underrated role of men in conception04:00 – 09:30: Top causes of poor sperm quality09:30 – 17:00: Celibacy, Low Libido and Infertility 17:00 – 19:30: Psychological fears around male infertility19:30 – 22:30: Aesthetics vs. fertility, and Panchakarma success story22:30 – 29:00: Factors affecting sexual performance29:00 – 39:00: Sedentary unhealthy lifestyle39:30 – 40:07: Closing Notes Guest Profile: Sidanta Goggate is a spiritual fertility and pre-postnatal coach with over 7 years of experience in Pranic healing, yoga, and energy medicine. She integrates ancient practices like Garbha Sanskar and Beej Shuddhi with modern methods to support conscious conception, hormonal health, and emotional healing in order to help couples prepare for parenthood.Reach Out To her on https://linktr.ee/siddhanta.gogate If you are interested in doing one on one Ayurvedic consultation with Dr Vignesh Devraj, please find the details in this link: https://calendly.com/drvignesh/30-minute-session-with-dr-vignesh-devraj-md-ay-istIf you are economically challenged, please use the form provided to request a free Ayurvedic consultation here. (or copy paste this in your browser: https://docs.google.com/forms/d/e/1FAIpQLSd29nHcrC1RssR-6WAqWCWQWKKJo7nGcEm8ITEl2-ErcnfVEg/viewform )BALANCE THE MIGHTY VATA - ONLINE COURSE NOW AVAILABLE What makes Ayurveda unique in its treatment approach is its practical wisdom on the concept of Vata. Vata is responsible for Prana - the life energy, nervous system - the master panel of our body, and our emotions. In Ayurveda, it is mentioned that controlling Vata is the most difficult part of healing and recovery. Recently, I have recorded a workshop on - Balancing The Mighty Vata which has over 6 hrs of content, with notes filled with practical inputs that can be integrated into our life. You can access this at https://drvignesh.teachable.com/For further information about Dr Vignesh Devraj, kindly visit www.vigneshdevraj.com and www.sitaramretreat.com Instagram - @sitarambeachretreat | @vigneshdevrajTwitter - @VigneshDevrajWe truly hope you are enjoying our content. Want to help us shape and grow this show faster? Leave your review and subscribe to the podcast, so you'll never miss out on any new episodes. Thanks for your support.Disclaimer: - The content of the podcast episodes is not intended to be a substitute for professional medical procedures, consultations, diagnosis, or treatment in any manner. We strongly do not recommend using the content of these episodes as medical advice for any medical conditions for you, others, or for treating your patients

¿Cómo se transforma una crisis profunda en una vida con propósito? En este episodio de Dale, Cuéntame, Claudia Niedzielski, autora bestseller y experta en transformación personal, abre su corazón y nos enseña cómo la salud mental, el liderazgo consciente y la responsabilidad radical pueden cambiarlo todo. Jairo Díaz Pedraza entrevista a Claudia en esta primera parte para explorar el impacto de enfrentar nuestras circunstancias personales, o familiares con valentía y como tomar el control total de nuestras decisiones a pesar de lo que nos suceda. Esta es una conversación imprescindible para quienes buscan sanar y liderar desde el alma. Comparte el episodio con alguien a quien le pueda ayudar.

In this episode of the Chasing Clarity: Health & Fitness Podcast, I'm diving deep into one of the most powerful strategies I use to help clients get lean and stay lean without living on low calories or constantly battling diet fatigue.We're talking all about the High Energy Flux Model also known as the eat more, move more method and why it's one of the most sustainable and effective frameworks for improving body composition, increasing metabolic flexibility, and making long-term fat loss actually stick.Here's what I cover in this episode:⁃ WHAT IS ENERGY FLUX?⁃ WHY I STARTED FOCUSING ON ENERGY FLUX & IMPLEMENTING A HIGH ENERGY FLUX MODEL IN PRACTICE⁃ WHY MOST PEOPLE FAIL TO STAY LEAN WITH THE TRADITIONAL APPROACH⁃ LOW VS. HIGH ENERGY FLUX — THE TWO PATHS TO MAINTENANCE⁃ THE GOAL OF MY HIGH ENERGY FLUX MODEL⁃ THE BENEFITS I'VE SEEN IN CLIENTS I'VE USED THIS APPROACH WITH⁃ THE RESEARCH ON HIGH ENERGY FLUX INCLUDING:⁃ HIGH FLUX HELPS YOU GET LEAN MORE EFFICIENTLY & OFFSET METABOLIC ADAPTATION⁃ HIGH FLUX LEADS TO BETTER BODY COMPOSITION OUTCOMES⁃ HIGH FLUX ALLOWS YOU TO STAY LEANER FOR LONGER INCREASING YOUR LIKELIHOOD OF FAT LOSS MAINTENANCE⁃ HIGH FLUX IMPROVES APPETITE REGULATION⁃ HIGH FLUX UPREGULATES TOTAL DAILY ENERGY EXPENDITURE (TDEE)If you're someone who's tired of yo-yo dieting and wants to stay lean without sacrificing performance, energy, or health, this episode is for you.WHERE TO CONNECT WITH ME:Follow Brandon on IG: https://www.instagram.com/brandondacruz_/For Info on Brandon's Coaching Services: https://form.jotform.com/bdacruzfitness/coachinginquiryEmail: Bdacruzfitness@gmail.comBrandon's Website: https://www.brandondacruzfit.com

Co-founder of Manchester's infamous Rhythm Theory parties, A.Morgan lands his inaugural mix for RYC, showcasing both the breadth of his style and clinicality of his mixing skillset. Fresh off the release of his five-tracker, ‘Hyper Tension', Morgan onboards the series with two hours of no-nonsense floor-destroying wares, stripped-down 4x4 aerobatics and epic-sized buildups. Muscular and mind-expanding, brace yourself for a set at the junction of proper hi-tech grit and heavily verbed-out grooves, merging the finest of classic 909-fuelled pound with atmospheric abandon and tape-delayed psychedelia. Blast this one out loud, all windows opened and woofers set to eleven. 

Send us a textCellular self-organization, cytoskeleton dynamics, and membrane wound healing.Episode Summary: Cell Biologist Dr. Bill Bement explains the dynamic world of the cell cortex, discussing how actin filaments and microtubules drive processes like cell division and wound healing through self-assembly and self-organization; energy dynamics of these processes; the role of rho GTPases in patterning; the implications for diseases such as cancer and muscular dystrophy, using vivid analogies and video demonstrations to make complex concepts accessible.About the guest: Bill Bement, PhD is a cell biology professor at the University of Wisconsin-Madison, where he has studied cellular processes for over 30 years. He leads a lab focused on the cell cortex, investigating cell division and repair. His work emphasizes self-organization and cytoskeletal dynamics, contributing to insights into diseases like muscular dystrophy.Discussion Points:The cell cortex, the outer layer of a cell, includes the plasma membrane & underlying proteins like actin & myosin, which enable dynamic shape changes.Actin filaments self-assemble without energy input, growing & shrinking to facilitate cell movement and division, while microtubules, stiffer hollow tubes, aid in chromosome separation.Self-organization in cells, driven by energy-dependent feedback loops, creates complex patterns like mitotic spindles.Cellular wound healing involves concentric rings of rho GTPases and actin, closing wounds rapidly, a process critical for surviving natural damage from mechanical stress or toxins.Energy costs of cytoskeletal rearrangements are significant but likely less than protein synthesis, though precise measurements remain challenging.Cancer metastasis may rely on enhanced cell repair, allowing metastatic cells to survive mechanical damage while squeezing through tissues.Muscular dystrophy involves excessive damage or impaired repair, highlighting the importance of cell repair mechanisms.Bement's lab is developing tools for synthetic self-organization, aiming to manipulate cellular processes to address repair deficits in diseases.Related episode:M&M 220: Cell Death, Oxidative Stress, PUFAs & Antioxidants | Pamela Support the showAll episodes, show notes, transcripts, and more at the M&M Substack Affiliates: KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off Readwise: Organize and share what you read. 60 days FREE through link SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

We catch up with Professor Thorsten Langer!Transition of youth with Duchenne muscular dystrophy: What are the key challenges in transitioning youth with Duchenne muscular dystrophy to adult care, and how can we address them?Join us for another brilliant conversation with a brilliant researcher - live from the EACD / IAACD Conference 2025, in Heidelberg Germany!

The classic suit silhouette is designed for a leaner build, emphasizing clean lines and a draped fit. For someone with significant muscle, this means common issues like tight shoulders, pulling across the back, and restrictive armholes. CONQUER SHYNESS

What actually changes in your muscles when you go from an easy jog to a fast interval run? In this episode, Dr. Lisa breaks down the muscular strategies behind increasing running speed—specifically the shift in how your calves, achilles tendon, and hips contribute as pace increases. Whether you're training for a 5K or a marathon, understanding this science can help you run faster and train smarter.Links and Resources: 7 Day FREE Trial to the Complete Runners Club (Strength Membership)NEW Training Plans: Customized and includes access to the Complete Runners ClubFREE Glute Max Exercises to improve activationHip Program: At home rehab program for hip injuries including hip impingement, gluteal tendinopathy, low back soreness/pain, SIJ pain, psoas/hip flexor pain, piriformis syndrome and ITB syndromeRunners Knee Program: At home rehab program for pain around the kneecap, under the knee cap or around the joint lineFoot and Ankle Program: At home rehab program for injuries including plantar fasciitis, shin splints, achilles tendinopathy, ankle sprains, posterior tibialis pain and big toe painResearch: https://www.jospt.org/doi/10.2519/jospt.2014.5433

I had breakfast this morning with nearly 100 men who gathered together for fellowship and spiritual warfare. I pastor a church where men are enthusiastically involved in disciple-making and pursuing Christ-likeness. I hear from other pastors all the time, “How do you get men involved at church because we are not being successful at it?” And I tell them that muscular Christianity is the key to living out the call of the gospel for men.

Bubbles is all banged up after a fancy dinner at the SPCA, maybe hair of the cock and a tiny chef will cheer him up? The Boys also have a f**k-ton of weird news, including the robot that went f**ky, the highest town in Turkey, and gourmet chicken fingers (the sh*t kind!) Also: Got kitty legal problems? Better Call Bubs!

Help! I'm too muscular! Improve your push/split jerk. Improve your pull-ups. Oly heavy day modifications.

Help! I'm too muscular! Improve your push/split jerk. Improve your pull-ups. Oly heavy day modifications.

From the Mountains to the Mission: Commander J.D. Donaldson & Captain Bradley Geary's Journey of Service and Sacrifice This week, Marcus and Melanie welcome Commander Jed “J.D.” Donaldson, and Captain Bradley Geary to the Team Never Quit Podcast. J.D Donaldson, a West Virginia native whose journey from small-town athlete to elite Navy SEAL leader is nothing short of remarkable. Raised in Hedgesville and shaped by strong family values and athletic discipline, J.D. earned a U.S. Naval Academy appointment and went on to win two national boxing championships before graduating with a degree in Physics (Oceanography). Selected for SEAL training alongside a small group of peers, J.D. would go on to serve in multiple SEAL Teams across global deployments, holding command positions at SEAL Team Eight and SEAL Team Four, and leading strategic operations in Africa with Special Operations Command. His time at the elite Naval Special Warfare Development Group (DEVGRU) marks the pinnacle of a career defined by leadership, courage, and brotherhood. Now, as Training and Facilities Manager at GBRS Group, J.D. continues to serve the veteran and first responder community, equipping them with the tools and training to thrive. In this episode, we explore how his experiences shaped his approach to leadership, resilience, family, and life after service. Captain Bradley Geary is a retired Navy SEAL officer with 24 years of distinguished service in Naval Special Warfare. A 2000 graduate of the U.S. Naval Academy and SEAL Qualification Training Class 234, he led elite teams across the globe—from SEAL Team Four to commanding SEAL Delivery Vehicle Team One. He most recently served as Commanding Officer of Naval Special Warfare Basic Training Command. Captain Geary holds a master's in Defense Analysis and has spent his career training, leading, and mentoring some of the most elite warriors in the world. In This Episode You Will Hear: • I was first chair trumpet in high school. Muscular lips. (22:38) • One of the psych's did a study of all the attributes access the teams to find out what's consistent across all the force. The only attribute he could find consistent with 100% of us the sense of levity – humor. (32:12) • In the darkest moments of our careers, you'll find the funniest things (33:20) • There's this one young officer standing there, smiling ear to ear. I said “Yo dude, I just cancelled your Christmas break, they got you wet and sandy. Why are you smiling? [His response was] “This is everything I was waiting for, and everything I hoped it would be.” (35:59) • Press into the suffering. All of a sudden, it's not enjoyable, but it changes your mindset. (36:47) • [Marcus] McGraw had more fractures than he had legs. No quit in this dude. (47:18) • The guy next to me, Greg Klein, a huge Green Beret and Marine Force Recon. The instructor says “Klein, what're you doing here? You're Army Green Beret; you're Marine Force Recon. He's like “I thought I'd take a break.” (48:07) • Danny [Dietz] was probably the best pilot I've ever seen. He was amazing. (68:31) • We were in Chesapeake Bay, and I'm looking at the bearings. All of a sudden, I'm like “Hey! Danny!  We're like 90 degrees off course. What are you doing? Next thing I know, we bounce off the bottom. He had fallen asleep driving the STD. We had been out there so long that night. (68:52) • It comes back to Who's under the boat? Who's carrying their weight? Who's sacrificing for their teammates? And Danny [Dietz] was always that guy. (79:32) • [Danny Dietz is the] most selfless dude I've ever met. (79:58) • Whatever he [Danny Dietz] did, he did with excellence. He just owned it. (80:25) • It was the first time that I'd lost anybody close, and I walked out to the gravel, looked up to the heavens and I got to thinking. He was probably one of the key elements of my success in my entire career. I looked up to the stars and thought: “Alright Lord, If I was up there and Mike was down here, what would I say to him?” I'd say: “Think well of me and get back to work.” 120:54) • I hadn't brushed my teeth in like 84 hours. (121:53) • Leonidus didn't choose the 300 [Spartans] because they were the best warriors. He chose them because they had the best women. (139:21) • Suffering produces endurance, endurance produces character, character produces hope. All the answers are right in this book. (143:18) dannydietzmemorial.com Support TNQ   - IG: team_neverquit , marcusluttrell , melanieluttrell , huntero13   -  https://www.patreon.com/teamneverquit Sponsors:   - armslist.com/TNQ   - partnersinbuilding.com   - cargurus.com/TNQ - Navyfederal.org        -    - You can find Cremo's new line of antiperspirants and deodorants at Target or Target.com    - WARFARE IN THEATERS APRIL 11th Watch Trailer here: https://www.youtube.com/watch?v=JER0Fkyy3tw First Look Link: https://www.youtube.com/watch?v=-3DWuqiAUKg&t=3s    -   - PXGapparel.com/TNQ   - bruntworkwear.com/TNQ    - Selectquote.com/TNQ    - Groundnews.com/TNQ    - You can find Cremo's new line of antiperspirants and deodorants at Target or Target.com    - shipsticks.com/TNQ    - Robinhood.com/gold    - strawberry.me/TNQ    - stopboxusa.com {TNQ}    - ghostbed.com/TNQ [TNQ]   -  kalshi.com/TNQ   -  joinbilt.com/TNQ    - Tonal.com [TNQ]   - greenlight.com/TNQ   - PDSDebt.com/TNQ   - drinkAG1.com/TNQ   - Shadyrays.com [TNQ]   - qualialife.com/TNQ [TNQ]   - Hims.com/TNQ   - Shopify.com/TNQ   - Aura.com/TNQ   - Policygenius.com   - TAKELEAN.com [TNQ]   - usejoymode.com [TNQ]

On the Mailbag, Gill Gross answers your comments, including: are Joao Fonseca's recent losses concerning, thoughts on Jannik Sinner's Rome comeback and his more muscular frame, the best player who hasn't won a big title now that Casper Ruud has won Madrid, does a career in tennis media ever make me sick of tennis, Denis Shapovalov's slump, Masters 1000 chaos, Adrian Mannarino's bizarre results swings, Holger Rune's upset loss to Corentin Moutet, Novak Djokovic's participation in Geneva. Correction: when answering the top-100 question, I had the race pulled up... some players mentioned are inside the top-100 rankings. 0:00 Intro 2:00 IG Rapid Fire 20:45 Best Without Big Title 24:15 Career in Tennis 29:35 Muscular Sinner 32:45 Classiness vs Friction 36:21 Shapovalov Slump 40:56 M1000 Chaos 42:58 Adrian Mannarino 47:45 Moutet def Rune 50:40 Djokovic Geneva IG: https://www.instagram.com/gillgross_/ 24/7 Tennis Community on Discord: https://discord.gg/wW3WPqFTFJ Twitter/X: https://twitter.com/Gill_Gross The Draw newsletter, your one-stop-shop for the best tennis content on the internet every week: https://www.thedraw.tennis/subscribe Become a member to support the channel: https://www.youtube.com/channel/UCvERpLl9dXH09fuNdbyiLQQ/join

5/7/25 - Hour 2 Rich and the guys break down the night in the NBA Playoffs that featured more wins be the road teams including the Warriors, who lost Steph Curry to a hamstring injury, taking Game 1 from the Timberwolves, and Tyrese Haliburton looking like anything but overrated in the Pacers comeback win to take a commanding 2-0 lead on the top-seeded Cavaliers. Sports Illustrated's Chris Mannix joins Rich in-studio to discuss Rich's impending ‘Celebrity Family Feud' showdown against Dan Patrick, how Steph Curry's injury could hamstring the Warriors' playoff hopes, the Lakers' and Clippers' big offseason decisions, if the Milwaukee Bucks will trade Giannis Antetokounmpo, the Celtics missing a whopping 45 three-pointers in their Game 1 loss to the Knicks, Nikola Jokic's odds to take the Denver Nuggets back to the NBA Finals, and more. Rich discusses how a Giannis Antetokounmpo trade could seismically change the NBA's landscape. Please check out other RES productions: Overreaction Monday: http://apple.co/overreactionmonday  What the Football with Suzy Shuster and Amy Trask: http://apple.co/whatthefootball The Jim Jackson Show: https://podcasts.apple.com/us/podcast/the-jim-jackson-show/id1770609432 No-Contest Wrestling with O'Shea Jackson Jr. and TJ Jefferson: https://podcasts.apple.com/us/podcast/no-contest-wrestling/id1771450708 Learn more about your ad choices. Visit podcastchoices.com/adchoices

Coach Ted talks about overcoming the relative weakness that leads to tension and repetitive stress injuries. (Originally aired 07-22-2024)

El tejido muscular cardíaco, también conocido como miocardio, es un tejido muscular especializado que se encuentra exclusivamente en el corazón, responsable de bombear sangre a todo el cuerpo.

What's the benefit of training higher reps? In this episode, the Team at Legacy Personal Training discusses muscular endurance training and how performing higher reps with lower weights benefits your performance, prevents injury, and increases mental toughness.

This week, we're talking about degrowth, misunderstandings, and liberation theology.Intro Music by Amaryah ArmstrongOutro music by theillogicalspoonhttps://theillalogicalspoon.bandcamp.com/track/hoods-up-the-low-down-technified-blues*Support The Magnificast on Patreon*http://patreon.com/themagnificast*Get Magnificast Merch*https://www.redbubble.com 

The sole focus of our discussion is centered on the intricacies of vocal articulation and the critical role of the tongue in the production of sound. We delve into the mechanics of speech, highlighting the necessity for proper utilization of all four articulators—namely the tongue, jaw, lips, and cheeks—to achieve a more resonant and controlled vocal performance. Throughout the discourse, I emphasize that many individuals possess the innate ability to sing; however, excessive tension, particularly within the tongue, can significantly impede vocal flexibility and expression. We explore the psychological factors that contribute to vocal habits, recognizing that a shift in technique can yield immediate improvements in vocal quality. Ultimately, our objective is to empower artists to harness their voices effectively, fostering a sustainable approach to vocal health and performance.Takeaways: Articulation is crucial for effective communication, and understanding the four articulators can significantly enhance one's speech. Muscular dysphonia, characterized by excessive tongue tension, can obstruct vocal performance and should be addressed for optimal vocal health. The coordination of vocal cords is essential, and tension in the face and tongue can hinder pitch variation, making relaxation imperative. Immediate results in vocal training are achievable, reflecting a strong coaching philosophy focused on facilitating artists' goals. Companies mentioned in this episode: Shawn Mendez Aaron Lowe Creed Cher Christina Aguilera Stevie Wonder Bruno Mars Chaka Khan Bryan Adams Scott Hellman Roy Woods

Happy banging day! Ricky's been trawling Plenty Of Sharks for a date, and Bubs is hoping for a Swedish massage. Julian's got money on his mind with a greasy new business scheme... anyone wanna buy 100,000 eggs?! Plus: Can you beat the Boys in a rock band quiz?