Podcasts about mitochondrial

Sandy spent years misdiagnosed with Type 2 diabetes and battling medical gaslighting. Discover how the RADIANT study and AI uncovered her true diagnosis: Maternally Inherited Diabetes and Deafness. ABLEnow save for today's needs or invest for tomorrow Eversense CGM Medtronic Diabetes Tandem Mobi ** Use code JUICEBOX to save 20% at Cozy Earth  CONTOUR NextGen smart meter and CONTOUR DIABETES app Dexcom G7 Go tubeless with Omnipod 5 or Omnipod DASH * Get your supplies from US MED  or call 888-721-1514 Touched By Type 1 Take the T1DExchange survey Apple Podcasts> Subscribe to the podcast today! The podcast is available on Spotify, Google Play, iHeartRadio, Radio Public, Amazon Music and all Android devices The Juicebox Podcast is a free show, but if you'd like to support the podcast directly, you can make a gift here or buy me a coffee. Thank you! *The Pod has an IP28 rating for up to 25 feet for 60 minutes. The Omnipod 5 Controller is not waterproof.  ** t:slim X2 or Tandem Mobi w/ Control-IQ+ technology (7.9 or newer). RX ONLY. Indicated for patients with type 1 diabetes, 2 years and older. BOXED WARNING:Control-IQ+ technology should not be used by people under age 2, or who use less than 5 units of insulin/day, or who weigh less than 20 lbs. Safety info: tandemdiabetes.com/safetyinfo Disclaimer - Nothing you hear on the Juicebox Podcast or read on Arden's Day is intended as medical advice. You should always consult a physician before making changes to your health plan.  If the podcast has helped you to live better with type 1 please tell someone else how to find it!  

Send Vanessa a Text MessageA special listener discount is available for Mara Labs products featured in this episode: Explore Mara Labs (Code is VANESSA)If you enjoy the podcast and want to support Vanessa's work, you can do so here: Buy Me a Coffee – Intentionally WellIn this episode, I'm joined by David Roberts, founder of Mara Labs, for a conversation exploring cellular health, modern environmental stressors, and the body's natural resilience systems.David's journey into this space began after his late wife Mara's cancer diagnosis, which led him to deeply explore plant-based compounds and how they interact with cellular protection and repair mechanisms. That path eventually led to the development of BrocElite, a stabilized sulforaphane supplement designed to support detoxification pathways, mitochondrial function, and overall cellular resilience.We discuss topics including sulforaphane, oxidative stress, detoxification and autophagy pathways, metabolic health and GLP-1 signaling, genetic variability such as MTHFR and COMT, and how modern environmental exposures like microplastics may be impacting overall health.This is a wide-ranging conversation aimed at helping make complex biology more understandable and grounded in real-life application.Key Topics Covered: Sulforaphane and cellular defense systems  Detoxification pathways and autophagy  Mitochondrial health and oxidative stress  Modern environmental exposures (including microplastics)  Metabolic health and GLP-1 signaling  Genetic variability (MTHFR / COMT) and sensitivity  Why some people feel more reactive in today's environment Sulforaphane and pet health BrocElite and Mara Labs story Connect with David:Mara Labs on InstagramExplore Mara LabsConnect with Vanessa and the podcast: IWP Website: Intentionally Well PodcastIWP Recommended ProductsPodcast on InstagramVanessa on InstagramPodcast on YouTubeVanessa on TikTokVanessa on XEmail: intentionallywellpodcast@gmail.comSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

What if fatigue, inflammation, poor recovery, hormone issues, bloating, brain fog, and "feeling stuck" are not simply about doing more… …but about impaired FLOW inside the body? In Part Three of The Terrain First Series: Flow, Signals & the Future You, Debbie Potts dives deep into the physiology behind her F.L.O.W. Foundation™ and explains why healing depends on movement, communication, oxygen delivery, drainage, and nervous system safety. In this episode, you'll learn: What F.L.O.W. stands for: Neural FLOW Lymphatic FLOW Oxygen FLOW Waste & Bile FLOW Why the nervous system controls digestion, recovery, and repair How chronic stress physiology may impair stomach acid, bile flow, motility, and mitochondrial function Why the lymphatic system is one of the most overlooked systems in modern health The connection between oxygen delivery, nitric oxide, mitochondria, and metabolic resilience Why "Drainage Before Detox" matters How sluggish bile flow may contribute to hormone recirculation, inflammation, and digestive dysfunction Why high performers often stay stuck in survival physiology despite "doing everything right" How the body constantly asks: Am I safe? Can I recover? Should I build or defend? Debbie also connects the dots between: The Cell Danger Response Vagal tone Mitochondrial communication Inflammation signaling Metabolic flexibility PNOĒ metabolic testing Terrain First physiology The FutureYou Blueprint™ This episode is a deep dive into why the body cannot heal efficiently when information, oxygen, nutrients, hormones, immune signals, and waste cannot move through the system properly. Because healing is not about forcing the body. It's about creating the conditions where the body finally feels safe enough to repair. Learn more about coaching, PNOĒ metabolic testing, and The FutureYou Blueprint™ at: https://debbiepotts.net Subscribe to Coach Debbie Potts on YouTube: https://www.youtube.com/@coachdebbiepotts #TerrainFirst #FutureYouBlueprint #FlowFoundation #VagusNerve #Mitochondria #MetabolicHealth #FunctionalMedicine #GutHealth #HormoneHealth #PNOE #Longevity #CoachDebbiePotts #CellDangerResponse #MetabolicFlexibility #HealthyAging

Why does exercise feel harder now—even though you're still training? Why does recovery take longer? Why are you doing "all the right things" but still struggling with fatigue, muscle loss, slower metabolism, or reduced performance? In Part 4 of my Terrain First Series, we dive into the O in the FLOW Method: O = Oxygen Flow Because Oxygen Flow is about much more than breathing. It influences: ✓ Energy production (ATP) ✓ Recovery capacity ✓ Muscle building and repair ✓ Mitochondrial health ✓ Nervous system regulation ✓ Nitric oxide production ✓ Metabolic flexibility ✓ Healthy aging and resilience In this episode, we explore: • What Oxygen Flow actually means • Why exercise feels harder after 40 • The connection between oxygen, mitochondria, and energy production • How nitric oxide affects circulation and performance • Why the vagus nerve influences breathing and recovery • Signs your Oxygen Flow may be impaired • Practical strategies to improve oxygen delivery, utilization, recovery, and resilience If you're an active adult, endurance athlete, high performer, or someone trying to improve metabolism and age stronger—not slower—this episode is for you. Because sometimes the problem isn't motivation. Sometimes the problem is physiology. Learn more about PNOĒ metabolic testing, coaching, and The FutureYou Blueprint: www.debbiepotts.net COMMENT BELOW: Have you noticed recovery getting harder as you age? #Metabolism #Recovery #HealthyAging #MidlifeFitness #VO2Max #Mitochondria #Hormones #Perimenopause #MenopauseFitness #PNOE #Fatigue #EnduranceAthlete #MuscleHealth #Biohacking #FutureYou

You're not imagining your fibromyalgia pain or symptoms. Discover common fibromyalgia causes and triggers, and learn how to find fibromyalgia relief by addressing the underlying issue.0:00 Introduction: Fibromyalgia explained 0:42 Fibromyalgia causes and triggers 1:45 Low vitamin D and fibromyalgia3:19 Mitochondrial damage and fibromyalgia symptoms5:00 What to do for fibromyalgia relief5:31 Fibromyalgia research and recovery7:58 Fixing low vitamin D 8:39 Magnesium deficiency and fibromyalgia symptoms 10:34 More fibromyalgia relief tips

Long COVID and sports injuries are becoming impossible to ignore—and this episode explores why more athletes may be dealing with fatigue, soft tissue breakdown, and prolonged recovery after viral illness. In this powerful conversation, Dr. Greg Jones sits down with Dr. Muhammad Mansour, a naturopathic doctor and regenerative medicine specialist who treats elite athletes at the highest levels.In this episode, you'll learn how long COVID may affect skeletal muscle, mitochondrial function, exercise tolerance, and systemic inflammation—and why these issues can persist even after the initial infection appears to resolve. Dr. Mansour explains how athletes can miss early warning signs, why “pushing through” fatigue may backfire, and how a more individualized recovery strategy may be critical in the post-pandemic era.If you're an athlete, coach, practitioner, or health-conscious listener trying to understand the intersection of long COVID, inflammation, and injury risk, this episode offers a science-informed perspective on what recovery may require now.

What if your fatigue, brain fog, stubborn weight gain, slow recovery, and lack of motivation all traced back to one hidden problem inside your cells?Your mitochondria are the tiny energy factories that power every organ, every thought, every heartbeat, and every movement you make. But modern stress, toxins, poor nutrition, aging, and environmental overload are silently damaging them—leaving millions running on empty.In this eye-opening episode, I reveal the ultimate biohacker's guide to mitochondrial support supplements and how optimizing your cellular energy can completely transform your health, metabolism, performance, and longevity.If you're constantly tired, battling brain fog, struggling to lose weight, or looking for the next level of health optimization, this episode could change how you think about energy forever. Supplements Featured In This Episode:• Acceleradine® Iodine https://www.acceleratedhealthproducts.com/products/acceleradine-iodine-supplement  • Accelerated Liver Care® https://www.acceleratedhealthproducts.com/products/accelerated-liver-care• Accelerated AMINOS® https://www.acceleratedhealthproducts.com/products/accelerated-aminos • Accelerated BIO PEPTIDES™ https://www.acceleratedhealthproducts.com/products/accelerated-collagen-peptides• Accelerated Scalar Copper® https://www.acceleratedhealthproducts.com/products/accelerated-scalar-copper • Accelerated Methylene Blue® https://www.acceleratedhealthproducts.com/products/accelerated-methylene-blue-supplement Not sure what food to eat and avoid? This guide is for you.⬇️

When my daughter was six months old, her platelet count dropped to 2,000. Over the next two years she was diagnosed with a mitochondrial disease (MELAS), lupus, and immune thrombocytopenia (ITP), and was seen by nine different specialists. Not one of them connected those findings to each other. This is the story of what almost losing her taught me about chronic disease, why our current model of medicine keeps failing complex and chronically ill clients, and why I am back on the podcast after almost a decade away. I am Andrew Reid, founder of Medgeeks. I trained as a Physician Assistant, spent five years in primary care, and have spent over a decade since educating clinicians. None of it prepared me for my own daughter. To help her, I had to go back and learn the biology underneath chronic disease: mitochondrial medicine, biochemistry, molecular biology, genetics, metabolomics, and clinical nutrition. What I found changed how I think about every client I see. Going forward, this show is about that biology and the clinical reasoning that follows from it. Mitochondrial function, the cell danger response, metabolic health, autoimmune disease, insulin resistance, and the systems-based, root-cause approach to chronic disease that conventional training leaves out. We also get into the other side of that same continuum: building muscle, exercise as medicine, sleep, nutrition, and the levers that move someone toward genuinely optimal health. The goal is simple: better health, with better science. Whether you are a clinician reasoning through complex clients, someone facing chronic illness in your own life or your family's, or you are already healthy and want to understand how to optimize and protect that health for the long run, this is the work I want to do in front of you. Learn more here: medgeeks.co If this resonated, the best thing you can do is follow the show wherever you listen and leave a review. It genuinely helps more clinicians and more families find this work. Thank you for being here.

In this episode of the Neuroveda Podcast for Complex Health, Gillian Ehrlich sits down with returning guest Dr. Dawn Ibsen, compounding pharmacist and passionate advocate for personalized medicine. Together they unpack the science, history, and growing interest around methylene blue — from its origins as a treatment for malaria to its modern use in brain health, mitochondrial support, longevity, and biohacking.They also dive into the rapidly changing world of compounding pharmacies, including concerns surrounding compounded thyroid medications, the evolving landscape of peptide access, and the balance between innovation, safety, and patient care. This conversation explores what happens when cutting-edge medicine meets regulation and why personalized treatment still matters.Topics include:• Methylene blue safety, dosing, and mechanisms• Mitochondrial health and energy production• Compounding pharmacy quality and patient advocacy• Thyroid medication changes• Peptide regulation and current challenges• The future of personalized medicineBio: Dr. Dawn Ipsen, PharmD, FAPC, FACVP, FACA is a compounding pharmacist with more than 25-years of experience serving human and veterinary patients. She is the owner of two community-based compounding pharmacies in Washington state and is recognized for her expertise in personalized medication therapy, quality compounding practices, and patient-centered care.Dr. Ipsen holds an APC Fellowship and is also a Fellow of the American College of Veterinary Pharmacists and American College of Apothecaries, reflecting her advanced training and leadership in both human and veterinary compounding. In addition, she is a clinical instructor for the University of Washington School of Pharmacy and an affiliate faculty member for Bastyr University. Her professional focus includes women's health, hormone therapy, low-dose naltrexone, dermatology compounding, and complex veterinary medication solutions for small animals, exotic pets, and large animal patients.Dr. Ipsen is deeply engaged in pharmacy advocacy, education, and legislative efforts to protect patient access to compounded medications. She currently holds an APC Board of Directors position and is the founding chair for the WA State Pharmacy Association (WSPA) - Compounding Special Interest Group. The WSPA awarded her with the Distinguished Leadership Award in 2023 and the UW School of Pharmacy Distinguished Alumni Award in 2021. Dr. Ipsen regularly collaborates with prescribers, healthcare professionals, and educators to improve the therapeutic outcomes, health, education and vitality of the communities we serve.

All links here: ⁠https://hunterwilliamshealth.com/linksSS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?If you're a clinician or just researching for yourself, this is the complete user's guide.For entertainment purposes only.Timestamps00:00 Intro01:00 What this masterclass covers03:18 Why SS-31 matters and what makes it different03:46 FDA approval and the Forzenity brand name04:50 Peptide foundations and how SS-31 is made05:52 The SS-31 sequence and the Seto-Schiller naming origin06:40 Mitochondria 101 and why ATP matters07:28 Mitochondrial dysfunction across chronic disease08:34 Cardiolipin, cristae, and Barth syndrome09:34 Why SS-31 is not a direct antioxidant10:46 How SS-31 actually works (the upstream Godfather effect)11:12 Why no receptor means no desensitization13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)14:24 Who should skip it15:34 The three-tier dosing ladder16:54 The FDA-approved 40mg dose and diminishing returns19:08 Dosing by goal (longevity, performance, recovery, healing)19:48 Cycling logic and the 8-12 week framework20:22 When to dose (morning vs night)21:24 What to expect and when (week-by-week timeline)22:20 Why cycle if it doesn't desensitize24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)26:18 Reconstitution and injection technique28:22 What to track (subjective markers and biomarkers)29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs31:28 Stacking for cognition and visceral fat32:26 Troubleshooting "I don't feel anything"33:54 Injection site reactions34:36 When to discontinue and the first-two-week headache window35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)37:54 Research grade vs pharmaceutical cost difference38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)40:30 Final thoughts and where SS-31 sits in the broader picture42:20 Closing

Unpack the pros and cons of keto and fasting for mitochondria, and discover why the Mediterranean diet leads the pack in boosting mitochondrial health. #KetoDiet #FastingBenefits #Mitochondria #HealthTalks

Get My Myoscience Vitamin D3 + K2 - https://bit.ly/4tSrys5 

The Hidden Genome Inside Every CellMost of us learned that mitochondria are the “powerhouse of the cell.”What we didn't learn?They carry their own DNA — and that DNA may hold crucial answers to aging, neurodegeneration, and rare childhood diseases.In this episode of Research Renaissance, host Deborah Westphal speaks with Dr. Stefan Isaac, Assistant Professor at Boston University and 2025 Toffler Scholar, about how mitochondrial DNA is organized, regulated, and why its dysfunction may contribute to diseases ranging from Leigh syndrome to Alzheimer's.

What if aging isn't a hundred separate problems but a single one — an energy crisis inside the tiny power plants of every cell? At 91, Dr. John G. Cramer is betting his own body on the answer.In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with Dr. John G. Cramer — Emeritus Professor of Physics at the University of Washington and author of "How to Live Much Longer" — the oldest human on Earth to receive an experimental mitochondrial transplant. They unpack a unifying theory of aging built around damaged mitochondrial DNA, why replication errors (not just free radicals) drive most of the damage, and what it felt like to receive escalating doses of "Mitlets" — liposomes carrying fresh mitochondria harvested from young blood platelets — at a Texas right-to-try clinic.Buy Dr. Cramer's book "How to Live Much Longer": https://www.amazon.com/How-Live-Much-Longer-Cramer/dp/B0DV3ZW5T6 Cramer & Benson white paper (CBC): https://faculty.washington.edu/jcramer/Bio/CBC.pdf Mitrix Bio: https://mitrix.bio/CHAPTERS00:00 Cold open — "the oldest young human on the planet" 01:18 Meet Dr. John Cramer: physicist turned longevity pioneer at 91 03:45 Why a physicist became obsessed with aging 06:20 The unifying theory: aging as mitochondrial DNA damage 09:40 The 16,569 base pairs that run your life 13:05 Replication errors vs. free radicals — correcting Denham Harman 16:30 The damage doubling time: 12 years, then 3-4 19:50 David Sinclair's information theory of aging 23:15 James McCully and the birth of mitochondrial transplantation 27:00 "No negative results, only spectacular successes" 30:25 Mitrix Bio, Tom Benson, and the Mitlet platform 34:10 Inside Cramer's four Texas right-to-try sessions 38:30 Arm injection, belly fat, and the IV mainline that worked 42:15 What it actually feels like to receive young mitochondria 45:40 Haplogroup H2A1G1 and the Norwegian great-grandmother 48:20 The economics: scaling Mitlets to the world 51:05 Becoming the oldest young human — target age 129 54:30 What Cramer wants you to do tomorrow morning 57:00 Final reflections and where to find the bookKEY STUDIES & SOURCESCramer J.G. & Benson T. — Cellular Bioenergetic Crisis white paper: https://faculty.washington.edu/jcramer/Bio/CBC.pdfHarman D. (1972) — The biologic clock: the mitochondria?: ⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

What if the fatigue, brain fog, and loss of strength many women experience after 50 are not simply hormonal, but reflect deeper shifts in metabolism, muscle, and mitochondrial function? In this insightful episode, Dr. Elizabeth Goldspink reframes midlife as a metabolic and neurological transition rather than a purely hormonal one. She explains how muscle acts as a longevity organ, how mitochondrial efficiency impacts both energy and cognition, and how targeted lifestyle and nutrition strategies can restore resilience. This empowering conversation offers practical, science-informed steps to help women take control of how they age. Dr. Elizabeth Goldspink is a naturopathic doctor, women's health researcher, and founder of Wellex. She has more than 16 years of clinical experience supporting women's hormonal, metabolic, and immune health. Dr. Goldspink is a published author in peer-reviewed medical journals and has completed advanced training in mind-body medicine at Harvard University. Her work focuses on translating complex scientific research into practical, personalized health strategies. She has helped thousands of women restore energy, resilience, and long-term well-being. Her current focus is on evidence-based supplementation and metabolic health optimization for women in midlife and beyond. Episode Timeline 00:00 – Welcome and introduction 02:30 – Midlife symptoms reframed: beyond hormones to metabolism and mitochondria 04:00 – Dr. Goldspink's personal journey from marketing professional to naturopathic medicine 06:00 – Why brain fog, fatigue, and strength loss signal deeper biological shifts 08:00 – Muscle as a longevity organ and its role in metabolic and cognitive health 11:00 – The metabolic functions of muscle and the importance of myokines 13:30 – Resistance training and why lifting weights matters for women over 50 16:00 – Nutrition fundamentals: protein intake, glycemic stability, and whole foods 19:00 – Mitochondrial health and its connection to energy and cognition 22:00 – Practical strategies to optimize mitochondria without complex protocols 25:00 – Creatine explained: benefits for muscle, brain, and aging 29:00 – Real-world recovery and rebuilding strength after health setbacks 31:00 – Brain training, lifestyle habits, and community connection 33:00 – Managing stress, social media overload, and mental resilience 35:00 – Supplement strategy after 50: what to use and what to avoid 37:30 – Common mistakes: overuse of antioxidants and low-quality supplements 40:00 – The origin of Wellex and a mission to support underserved women's health needs 43:00 – Practical daily steps to rebuild resilience and support healthy aging 45:00 – Wrap-up and key takeaways Connect with Dr. Elizabeth Goldspink Website: https://wellex.co Science-backed supplements for women's metabolic and hormonal health Information on clinical research and product formulations Call to Action Find Growing Older Living Younger: The Science of Aging Gracefully and the Art of Retiring Comfortably at www.gillianlockitch.com (North America) or on Kindle Subscribe to Growing Older Living Younger on your favorite podcast platform and leave a review to help others discover the show. Join the Growing Older Living Younger Community  Connect with Dr. Gillian Lockitch at https://www.askdrgill.com/ or email: askdrgill@gmail.com Download Guide to Nature's Colorful Antioxidants. 2026 

In part one of this series, Dr. Katie Krulisky and Dr. Cristina Domínguez-González discuss when a neurologist should start thinking about mitochondrial disease.  Show citation: Bermejo-Guerrero L, Restrepo-Vera JL, Martin-Jimenez P, et al. Clinical Heterogeneity and Candidate Biomarkers in POLG-Related Mitochondrial Disease. Neurol Genet. 2026;12(2):e200365. Published 2026 Mar 10. doi:10.1212/NXG.0000000000200365  Show transcript:  Dr. Katie Krulisky: This is The Neurology Minute, and this will be a two-part series. I've had the pleasure of speaking with Cristina Domínguez-González from the 12th of October University Hospital and its affiliated Health Research Institute in Madrid, Spain. I'm Katie Krulisky from the University of Utah. We've just recorded a full podcast on our paper, Clinical Heterogeneity and Candidate Biomarkers and POLG-related Mitochondrial Disease, which has been published in Neurology Genetics. So for our first minute, Cristina, when should a neurologist start thinking about mitochondrial disease? Dr. Cristina Domínguez-González: Mitochondrial diseases are among the most common inherited neurological disorders. Think of them whenever you see compatible features like ptosis ophthalmoplegia, polyneuropathy, ataxia or myopathy, especially when they occur in combination. But even when these features appear in isolation, mitochondrial disease should still be part of the differential. This is particularly important because many patients do not present with a full classical picture, especially in early the disease course. In practice, this means maintaining a low threshold to consider mitochondrial disease, even in a typical presentations. Dr. Katie Krulisky: Thank you so much. And for more information on mitochondrial disease and POLG-related disorders, do listen to the full neurology podcast. Again, I'm Katie Krulisky from the University of Utah with Cristina Domínguez-González from the 12th of October University Hospital and its affiliated Health Research Institute in Madrid, Spain.   

I'm kicking off the brand-new Her Stack series — a women's health-focused series designed to break down common goals through nutrition, lifestyle, biohacking, supplements, and peptides. Today's focus is energy: why so many women feel tired, wired, depleted, or stuck in the afternoon crash cycle, and what it actually takes to rebuild energy from the foundation up. I talk about mitochondrial health, circadian rhythm, HPA axis dysregulation, postpartum and perimenopause-related energy shifts, hydration, protein, sleep, movement, peptides, and the 12-week framework I would use to start feeling like yourself again. Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity. I TALK ABOUT:  01:25 - Why Her Stack is built around women's health, longevity, and four core pillars 03:05 - Why low energy is the number one complaint I hear from women 10:55 - Why postpartum and perimenopause can create major energy shifts 12:20 - Simple questions to help you assess whether your energy is actually broken 15:25 - Key data points to track, including HRV, resting heart rate, body temperature, and sleep stages 19:00 - Labs to consider when fatigue, brain fog, or hormone changes are showing up 21:40 - Why nutrition is the foundation before supplements or peptides 28:40 - Why hydration and minerals matter more than just drinking plain water 34:50 - Mitochondrial nutrients that support energy production 39:35 - Morning sunlight, blue blockers, and sleep routines for circadian health 44:50 - How grounding may support cortisol, HRV, and inflammation 45:30 - Why Zone 2 cardio and heavy lifting are essential for women's energy and longevity 53:50 - Fringe and cutting-edge biohacks, including methylene blue, hyperbaric oxygen, ketamine therapy, and EMF mitigation 59:10 - Foundational supplements for energy, cognition, and mitochondrial health 1:04:10 - Peptides for energy, inflammation, stress, mitochondria, and recovery 1:14:40 - How peptide protocols may shift across postpartum, perimenopause, menopause, and breastfeeding 1:15:50 - The 12-week energy rebuilding plan 1:20:00 - Why energy restoration requires a holistic approach, not one quick fix RESOURCES: Join The LongHer Life for women-specific guidance on peptides, hormones, and longevity. Free Peptide Masterclass for Women: Join the waitlist for the next live class. The Her Stack Planner: The first peptide tracking journal built around female biology. PRODUCTS MENTIONED IN THIS EPISODE: Peptide Serum for Women Waitlist: Early access and founder's pricing. SiPhox Health At Home Blood Testing (code: BRITTANY10) Baja Gold Salt Mineral Sea Salt (code: BIOHACKINGBRITTANY) BiOptimizers Gut & Performance Supplements (code: BIOHACKINGBRITTANY) Filter Optix Blue Light Blocking Glasses (code: BIOHACKINGBRITTANY) HigherDOSE Red Light Therapy (code: BRITTANY15)  Pulsetto Vagus Nerve Stimulation (code: BIOHACKINGBRITTANY) Kineon Red Light Therapy (code: BIOHACKINGBRITTANY) Leela Quantum Tech EMF Protection (code: BIOHACKINGBRITTANY) Defender Shield EMF Protection (code: BIOHACKINGBRITTANY) Juunaday EMF Protection Clothes For Women (code: BRITTANY) Timeline Nutrition Mitochondria Supplement (code: BIOHACKINGBRITTANY) NOVOS Longevity Supplement (code: BIOHACKINGBRITTANY) Nuchido Time+ NAD+ Supplement (code: BIOHACKINGBRITTANY) LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

The “Perfect Body” Isn't What Instagram Sold You What does the “perfect body” actually look like?In Part 2 of Coach Alex's conversation on The Samir Show, the discussion moves beyond six-packs, big biceps, and Instagram fitness into something much more useful: building a body that can serve the mission.Coach Alex explains why excessive muscle can become a liability for operators, why the best body is not necessarily the one that attracts attention, and why true fitness is about capability, endurance, resilience, and recovery.This conversation also goes deep into metabolic health, protein intake, fatigue, sleep, dad bod, belly fat, cardiovascular fitness, diabetes risk, and why so many people feel exhausted in their 30s and 40s.The big idea: your body is not just about appearance. It is an asset. It carries your mind, your mission, your work, your family, and your calling.In this episode, Coach Alex and Samir discuss:Why the “perfect agent body” does not look like an Instagram fitness modelWhy endurance and cognitive integrity matter for real-world performanceHow your body and brain are deeply integratedWhy constant fatigue may be connected to poor metabolic healthThe role of protein in muscle, energy, aging, and blood sugar regulationWhy muscle loss accelerates with age — and how weight training helps slow it downHow sleep timing, deep sleep, naps, and circadian rhythm affect energyWhy belly fat is often connected to stress, poor fitness, and energy imbalanceThe difference between fasting, time-restricted eating, and ketosisWhy cardio is not mainly about burning caloriesHow walking, weight training, and sleep can help prevent diabetes and heart diseaseIf you are tired of treating your body like a vanity project — or ignoring it altogether — this episode will help you think differently.Your body is not an idol to worship.It is not a problem to ignore.It is a stewardship.Get the Faithful Fitness 40-Day Devotional here:FaithfulFitnessDevo.comAnd check out more conversations from The Samir Show.00:00 The perfect agent body01:36 Why the CIA body would not look like Instagram fitness02:21 Hypertrophy is only one fitness adaptation03:48 The capable body: strong, fast, endurable, and mission-ready05:09 Training bodies for the job, not choosing bodies for the job06:54 Treating the body like a national security asset07:32 Why poor health affects national security08:43 Endurance and cognitive integrity09:35 Energy, fatigue, and burnout10:08 Mitochondrial dysfunction and fat-burning capacity12:01 Carbs as short-term fuel, fats as long-term fuel13:56 Why protein matters15:13 How much protein the average person may need16:20 Why minimum protein recommendations may not be optimal18:14 Plant proteins, supplements, and vegetarian considerations19:39 Why muscle mass declines with age21:09 Weight training and preserving muscle tissue22:02 Why you may wake up more tired than when you went to bed23:11 Deep sleep, sleep inertia, and inconsistent rest25:43 Why naps help some people and ruin sleep for others27:28 Busy tired vs. metabolic or hormonal problems28:41 Why medication without lifestyle change misses the root30:34 Protein, prediabetes, and blood sugar regulation32:23 Protein intake and body composition33:41 Dad bod, belly fat, and fatherhood37:05 Hormonal changes after having a baby38:42 Keto, fasting, cardio, and stubborn belly fat39:29 Fasting vs. time-restricted eating40:34 Ketosis does not always mean body-fat loss41:50 Why cardio is not mainly for burning calories42:44 Nutrient density vs. energy density45:12 Running outside vs. treadmill48:19 Early warning signs for diabetes and metabolic disease49:00 VO2 and cardiovascular fitness as missed warning signs53:06 Basic tests for diabetes and heart disease risk55:20 Why food journaling is the first intelligence report59:35 Lifestyle changes with the biggest payoff01:00:10 Start small: 15 minutes a day01:01:46 Walking, adaptation, and energy01:02:40 Sleep, stress, and disease risk01:04:30 Creatine, sleep deprivation, and recovery support If this conversation challenged the way you think about your body, start with the Faithful Fitness 40-Day Devotional.It was written to help Christians stop treating the body as either an idol to worship or a problem to ignore — and begin seeing it as a gift to steward under Christ.Get Faithful Fitness here:FaithfulFitnessDevo.comThis conversation originally took place on The Samir Show.Check out Samir's work and follow his show for more thoughtful conversations on health, mindset, and human performance https://www.youtube.com/watch?v=lST4zzD4Hcs&t=387sBecome a supporter of this podcast: https://www.spreaker.com/podcast/faithful-fitness-with-coach-alex-vanhouten--5150768/support.

What if the key to healthier, younger-looking skin starts at the cellular level? In this episode of Accelerated Health with Sara Banta, I'm joined by Jessica Alcalde to explore the science behind the HigherDOSE Red Light Mask and how red light therapy may support cellular repair, collagen production, skin recovery, and overall wellness naturally.Discover why so many people are turning to red light therapy for anti-aging, inflammation support, improved skin tone, and recovery from daily stressors. We break down how specific wavelengths of red light interact with your cells, why mitochondrial health matters, and whether the HigherDOSE Red Light Mask actually lives up to the hype.If you've been struggling with dull skin, fine lines, inflammation, low energy, or slow recovery, this episode may completely change the way you think about skincare and wellness.Shop the HigherDOSE Red Light Mask here: https://www.awin1.com/cread.php?awinmid=86123&awinaffid=2614054 Supplements Featured In This Episode:• Accelerated Face Lift® Skincare Bundle https://www.acceleratedhealthproducts.com/products/accelerated-skincare-bundle• Accelerated Face Lift® Cream https://www.acceleratedhealthproducts.com/products/accelerated-face-lift-cream• Accelerated Face Lift® Mask https://www.acceleratedhealthproducts.com/products/accelerated-face-lift-mask• Accelerated Face Lift® Spray https://www.acceleratedhealthproducts.com/products/accelerated-face-liftNot sure what food to eat and avoid? This guide is for you.⬇️

Urolithin A (MitoPure)--Mitophagy, Muscle Recovery, Immunity, and Skin Health: Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company, details urolithin A (MitoPure), a postbiotic derived from pomegranate precursors that most people cannot produce due to microbiome differences. Currier explains MitoPure's mechanism—stimulating mitophagy to recycle dysfunctional mitochondria—and reviews evidence from multiple clinical trials. He reveals a Sports Medicine study in elite male distance runners showing reduced creatine kinase and lower perceived exertion, suggesting improved recovery, plus trials in middle-aged and older adults showing improvements in strength, six-minute walk test, and VO2 max at 500 mg–1 g doses. They also cover a Nature Aging immune study reporting rejuvenation of stem-like CD8 T cells with improved mitochondrial fatty acid oxidation, ongoing research directions, supplement quality/testing for athletes, and topical urolithin A skincare trials and partnerships, including L'Oréal Lancôme.

Dr. Hoffman continues his conversation with Dr. Brad Currier, clinical trial manager at Timeline, a Swiss biotech company.

In this episode of The Better Life, Dr. Mary Ann Pinkston sits down with Ray Solano of PD Labs to explore the cutting edge of peptide therapy: transdermal delivery. Moving away from traditional injections, they discuss the science of getting potent peptides like BPC-157, MOTC, and CJC/Ipamorelin into the body through the skin. Solano explains the importance of pharmaceutical quality over "black market" alternatives and reveals a potential breakthrough in topical Semaglutide for metabolic health. From upregulating mitochondria to improving sleep and reducing inflammation, discover how these "magic lotions" are making integrative medicine more accessible and effective. Key Takeaways The Shift to Transdermal: Advancements in specialized bases now allow fragile peptides to bypass the digestive system and needles, absorbing directly into the bloodstream. Mitochondrial & Energy Support: Insights into MOTC for cellular energy and CJC/Ipamorelin for natural growth hormone signaling. Innovation in Weight Management: A discussion on the potential for topical Semaglutide to address "food noise" and metabolic changes without injections. Quality Matters: Why sourcing from a compounding pharmacy is critical to avoid the "moonshine" version of synthetic peptides found online. See omnystudio.com/listener for privacy information.

In this video, Dr. Ruscio discusses the benefits of glutathione, the body's master antioxidant. He discusses how to boost glutathione naturally via the diet, supplements that help boost glutathione, and how to supplement with glutathione directly (including the best forms and doses of glutathione).   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

You are likely sacrificing long-term health for short-term gains because you're following a "get bigger" blueprint designed for a body you don't actually want. After 21 years in the trenches—from wrestling on the WWE developmental circuit to coaching at the legendary MI40 gym—Drew Donaldson realized that the massive, 275lb version of himself was a high-performance engine running on the wrong fuel. He rebuilt his entire philosophy around the GMT Framework, proving that elite recovery and gut health are the only way to stay undeniable without burning out. INSIDE THE EPISODE: The WWE Developmental Trap: Why the "just get bigger" coaching advice is a career-ending mistake for 90% of athletes. The 275lb Awakening: A raw look at the health cost of extreme size and the specific metrics Drew used to downsize while staying elite. The GMT Framework: A deep dive into the three-pillar system of Gut health, Mitochondrial efficiency, and targeted Training. Metabolic Flexibility: Why traditional "bulking" kills your ability to utilize fuel and how to fix your internal machinery. The "Third Answer": Why both the bodybuilding and biohacking worlds are currently missing the middle ground of sustainable performance. MEET THE GUEST: Drew Donaldson is a Tampa-based high-performance coach and the founder of the DDT Method. With over 15,000 hours of in-person coaching experience, Drew's journey took him from the center of the professional wrestling world to becoming a leading educator in hybrid training and cellular optimization. Today, he helps elite performers and business executives build resilient, athletic physiques by focusing on the biology of recovery rather than just the intensity of the lift. FIND DREW: Website: DDTMethod.com Instagram: @ddtmethod YouTube: @ddtmethod DDT Method Podcast: Available on Apple, Spotify, and Amazon Music Skool Community: skool.com/ddtmethod SUPPORT DAVE TATE'S TABLE TALK: Become a Channel Member: Join @eliteftsofficial FULL Crew Access: elitefts.com/join-the-crew Limited Edition Apparel: Shop Limited Edition TYAO Application: Apply Here SPONSORS & DISCOUNTS: elitefts: Get an extra 10% OFF (CODE: TABLETALK) — elitefts.com Marek Health: Get 10% OFF Your Labs (CODE: TABLETALK) — marekhealth.com/tabletalk LMNT: Free 8-count Sample Pack — drinklmnt.com/tabletalk MASS Research Review: Save 20% (CODE: ELITEFTS20) — massresearchreview.com RP Hypertrophy App: Get 10% OFF (CODE: TABLETALK) — rpstrength.com

Listen Now to 006 WTFuture New Living Expo Watch Now 006 WTFuture New Living Expo In this delightfully chaotic episode of What the Future, the hosts dive headfirst into the weird and wonderful, kicking things off with a recap of the multi-generational New Living Expo. It is a wild ride through reports of impending ET contact, channeling dragon energy, “walk-in” aliens treating human bodies like cosmic Airbnbs, and a surprisingly talented rapping event producer.   However, the mystical vibes quickly collide with technological paranoia as the crew debates “Mythos,” a god-like hacker AI from Anthropic, capable of effortlessly dismantling and repairing any operating system. Depending on which host you ask, this autonomous AI is either the ultimate catalyst for pushing humanity toward a telepathic, secret-free utopia or a privacy-destroying Skynet destined to replace every app on your smartphone.  The futuristic musings do not stop there, pivoting from inner space to outer space with news of the Curiosity rover stumbling upon the nitrogen and sulfur-bearing organic building blocks of life in Mars’ Gale Crater. Back on Earth, the hosts geek out over the bio-hacking potential of mitochondrial transplants and freshly accessible peptides like MOTS-c, which act as tiny cellular batteries to potentially reverse disease and cellular degradation.   Finally, with a little help from their resident AI assistant Ara, they unravel the ancient mystery of the Antikythera Mechanism—a 2,000-year-old, 26-gear Greek analog computer likely forged in Rhodes to track a 354-day lunar calendar. From alien hybrids to ancient gadgets and AI overlords, it is a whirlwind tour of everything past, present, and entirely out of this world. Enjoy!

Today, I'm pulling together some of the most impactful conversations from the last three months on the Podcast. From breaking down the pitfalls of trendy weight loss drugs to uncovering silent heart health risks, and exploring how mitochondrial transplants and trauma healing are rewriting the story of resilience, these moments have truly shifted my perspective on what it means to pursue lasting wellness. Here are the full episodes: #401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff #414: Drop Dead Healthy? Why "Fit" Women & Men Still Have Fatal Heart Attacks! l Dr. Regina Druz #419: Origin Of Disease Is Hiding In Your Cells! Doctor Reveals How To Fix It Now l Dr. Natalie Yivgi-Ohana #421: Why You Can't Hack Longevity Until You Heal Hidden Stored Trauma! l Dr. Aimie Apigian #417: Feeling Depressed? Watch This First (It Might Not Be What You Think) l Dr. Cynthia Keller l Ep  Episode Timestamps: Welcome and quarterly recap intro ... 00:00:00 Longevity is about pattern recognition, not single breakthroughs ... 00:00:41 GLP-1s require personalization, not a one-size-fits-all approach ... 00:04:25 GLP-1 hormone assessment and individualized plans ... 00:06:03 Delayed/suppressed GLP-1 function needs lifestyle changes ... 00:08:04 GLP-1 agonists enable, but don't replace, foundational health tweaks ... 00:09:06 Heart health: sick fat disease, inflammation and cardiac risk ... 00:12:30 GLP-1 and GIP peptides have powerful anti-inflammatory effects ... 00:15:35 Menopause amplifies pre-existing heart/metabolic risks ... 00:18:22 Mitochondrial transplants: emerging therapy for rare diseases ... 00:24:04 Every disease linked to—or helped by—mitochondrial function ... 00:27:00 Trauma healing is phased; start with the gentle approach ... 00:31:21 Chronic survival state rewires the nervous system ... 00:40:02 Covid's gut impact can trigger mood issues, fixed with key nutrients ... 00:50:00 Our Amazing Sponsors: Mitopure Gummies by Timeline - These clinically researched gummies support mitophagy to help renew your mitochondria and boost cellular energy, giving you a stronger biological foundation for resilience—visit timeline.com/nat20 to get 20% off. Quantum Upgrade - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it's easy to try for yourself. Visit quantumupgrade.io/NAT and use code NAT15 to start the free 15 day trial. Daily Gut Detox by Just Thrive Health – A gentle, science-backed detox powered by clinically proven immunoglobulins that bind and remove toxins while supporting your gut, immune system, and digestion—without harsh flushing or discomfort. Visit JustThriveHealth.com/NAT20 and use code NAT20 for 20% off your order, risk-free. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Dr. Bill Lawrence Episode

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity. Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production. But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen. MAPS PPL — https://mapsppl.com (code: ppl) SPONSORS Troscriptions — https://troscriptions.com/mindpump (code: mindpump) Seed — https://seed.com/mindpump (code: 25mindpump) 00:00 — Intro 5:56 — Dr. Scott Sherr's background and health optimization medicine framework 10:42 — Strengths and weaknesses of conventional vs alternative medicine 16:34 — Why 94% of US adults are metabolically unhealthy 22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better 25:48 — Deep dive into methylene blue — history and mechanisms 35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols 42:43 — Methylene blue and red light therapy synergy 48:55 — GABA system, B3-GABA, and the TroCalm formula explained 59:58 — Complete sleep optimization stack and nighttime routine 67:30 — Cordycepin benefits and immune support protocols PEOPLE MENTIONED Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection

What if feeling better didn't have to take months or years to figure out, but could start today? On this episode of The Dr. Hyman Show, I sit down with Dr. Scott Sherr to talk about why so many people feel stuck in what he calls a “sympathetic spiral of doom.” Energy is low, recovery isn't what it used to be, and there's a constant sense of stress that doesn't seem to resolve. We walk through what's actually happening beneath the surface, why it can be so hard to break out of that pattern once you're in it, and how to start shifting your energy and recovery. Watch the full conversation on YouTube, or listen wherever you get your podcasts. In this episode, we discuss: • Why you feel “tired but wired” and what it actually means for your body • What's keeping your energy low even when nothing obvious is wrong • How stress from your life and environment builds up and keeps you stuck • Why calming down doesn't always work—and what to focus on instead • How to start rebuilding your energy so your body can recover and adapt We shouldn't have to wait for something to go wrong to take action. The goal is to help your body function better so you can actually feel it day to day. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Perfect Amino, Korrus, Timeline, BON CHARGE, BIOptimizers and Pique. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15. Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79. Head to boncharge.com/hyman and use code HYMAN for 15% off. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. (0:00) Introduction and guest Dr. Scott Scherer (3:31) Understanding the sympathetic spiral of doom (5:06) Symptoms and signs of sympathetic overdrive (7:10) Sympathetic activation, mitochondrial function, and stress (10:02) Mitochondria: their role and impact in the body (12:31) Stress, metabolic dysfunction, and their effects (17:43) Nervous system, mitochondria, and the cell danger response (21:25) Survival, stress, and breaking the sympathetic spiral (23:11) Contributors to stress: top-down and bottom-up (25:56) Mitochondria, microbiome, and medication impacts (29:38) Mitochondrial dysfunction and mental health (32:19) Limitations of parasympathetic activation and addressing root causes (36:46) How mitochondrial stress leads to fight-or-flight (37:52) Steps to break the sympathetic spiral and support mitochondria (42:41) Methylene blue: benefits, uses, and safety (50:35) Methylene blue as an MAO inhibitor and for chronic infections (57:17) Case studies, third-party testing, and Transcriptions' evolution (1:02:36) Parasympathetic edge, recovery, and the GABA system (1:07:44) GABA, supplements, and interventions for stress (1:12:23) Addressing root causes and methylene blue usage (1:17:29) Transcriptions products, sleep formula, and practitioner ecosystem (1:19:49) OneBase Health, hyperbaric space, and final information

If you're doing everything “right”—eating well, taking supplements, working on your health—but still feel stuck, this might be the missing piece. Your body cannot heal if it thinks it's under threat. In this episode, we unpack why your nervous system may be the hidden driver behind inflammation, hormone imbalance, weight gain, and more—and how to finally shift your body into healing mode. Here's what could be keeping you stuck: • Why chronic stress and nervous system dysregulation can block healing—even when everything else is “on point” • How your nervous system impacts your gut, hormones, metabolism, immune system, and weight • The difference between feeling “tired but wired” vs. true resilience and what a regulated system actually looks like • Simple, science-backed ways to regulate your nervous system through blood sugar, breath, sleep, and daily habits You can't out-supplement or out-diet a body that feels unsafe. But when you learn how to regulate your nervous system, you unlock your body's natural ability to repair, rebalance, and heal. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year. Have a question you'd love answered on Office Hours? Submit it here   (0:00) Nervous system regulation, chronic stress, and healing (2:21) Simplifying the nervous system and resilience (4:06) Signs and effects of nervous system dysregulation (6:24) Characteristics of a regulated nervous system (7:39) Practical tips for nervous system regulation (10:09) Building muscle, improving sleep, and myths about regulation (12:20) Upcoming episode and sympathetic activation (14:09) Mitochondrial dysfunction and importance in health (18:37) Closing remarks and call to action

Welcome to this week's Midlife Minute episode. Today, I respond to a complex question from my free Facebook group.  Stay tuned as I explore the root cause of Melinda's persistent knee inflammation, from protein needs and recovery to mitochondrial support, and why eating “clean” does not always reduce inflammation. IN THIS EPISODE, YOU WILL LEARN: How persistent swelling and discomfort after 40 could reflect mitochondrial decline Why 20 to 25 grams of protein at a meal may not be enough to trigger muscle protein synthesis Why eating “really clean” while doing heavy exercise could create a relative energy deficiency Mitochondrial support supplements that are commonly used for repair and boosting mitophagy The benefits of the flavonoid, apigenin The value of CoQ10, especially for those on statin therapy Why melatonin is more than just a sleep hormone How BPC 157 differs from the experimental peptides available online Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Link: Troscriptions  - https://troscriptions.com/discount/CYNTHIA10

In this episode of the Gladden Longevity Podcast, Dr. Elizabeth Yurth shares her extensive journey in the longevity and regenerative medicine space, discussing the evolution and significance of peptides in healing and performance. She emphasizes the importance of understanding hormonal and peptide levels as we age, the role of mitochondria in energy production, and the critical aspects of immune regulation through the thymus gland. The conversation also covers the eight pillars of regeneration, highlighting the multifaceted approach needed for optimal health and healing. In this conversation, Dr. Yurth and Dr. Gladden discuss the importance of peptide therapy, particularly focusing on the replacement of lost functions due to aging, such as those of the thymus gland and mitochondria. They emphasize the need for personalized protocols and the cyclical use of peptides based on seasonal changes. The discussion also highlights the risks associated with unsupervised peptide use and the role of GLP-1s in weight management   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !  ·       Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://gladdenlongevity.short.gy/gladden-newsletter-pod ·       If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://gladdenlongevity.short.gy/gladden-vsl-pod     Takeaways ·       Dr. Elizabeth has been in the longevity space for over 20 years. ·       Boulder Longevity Institute was established to combine orthopedics and longevity medicine. ·       Peptides have gained popularity in the last decade for their healing properties. ·       BPC and TB4 are key peptides for injury recovery. ·       Peptides should be viewed similarly to hormones in terms of their necessity for healing. ·       Sympathetic overdrive can hinder healing processes. ·       Toxin elimination is crucial for effective healing. ·       Mitochondrial function is essential for energy production and overall health. ·       Mitochondrial peptides can repair and enhance mitochondrial function. ·       The thymus gland plays a vital role in immune regulation and function. The thymus gland's functions can be replaced with peptides. ·       Seasonal cycling of peptides can optimize health benefits. ·       Personalized protocols are crucial for effective peptide therapy. ·       Unsupervised peptide use can lead to health risks. ·       GLP-1s can help manage weight and preserve muscle. ·       AI can enhance the personalization of peptide therapies. ·       The body's ecosystem must be balanced for optimal health. ·       Peptides can significantly speed up healing processes. ·       Understanding the nuances of peptides is essential for safety. ·       Combining various therapies can lead to better health outcomes.     Chapters 00:00 Journey into Longevity and Peptides 03:04 The Role of Peptides in Regenerative Medicine 05:59 Understanding the Importance of Hormones and Peptides 08:59 The Eight Pillars of Regeneration 11:59 Mitochondrial Function and Energy Production 14:57 Mitochondrial Peptides and Their Impact 18:03 Thymus Gland and Immune Regulation 22:51 Replacing Lost Functions: Thymus and Mitochondrial Peptides 25:54 Seasonal Cycling of Peptides for Optimal Health 27:41 The Importance of Personalized Protocols in Peptide Therapy 30:35 Understanding the Risks of Unsupervised Peptide Use 32:43 The Role of GLP-1s in Weight Management and Muscle Preservation 36:19 The Future of Personalized Medicine: AI and Designer Peptides     To learn more about Dr.Elizabeth Yurth: Website: https://boulderlongevity.com/ Facebook: https://www.facebook.com/BoulderLongevityInstitute Instagram: @dryurth, @boulderlongevity YouTube: https://www.youtube.com/@dryurth Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw   Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.  

Elliot Overton is a nutritionist based in France, and is considered to be an expert in the clinical application of high-dose thiamine therapy. Elliot frequently lectures and speaks at educational events aimed at practitioners, helping to broaden the understanding and application of thiamine in clinical settings. Furthermore, he is cofounder and CEO of Objective Nutrients, a nutraceutical company specializing in excipient-free thiamine derivatives and related supplements. Elliot's overarching aim is to increase awareness about the benefits of thiamine through education and advocacy, striving to make this knowledge accessible to both practitioners and the general public.    In this episode, Dr. Brian and Elliot talk about… (00:00) Intro (04:17) (10:23) How Elliot first encountered thiamine (14:38) Thiamine and stress (18:11) The myriad benefits of thiamine (33:05) Supplemental and dietary sources of thiamine (38:16) Mitochondrial health and thiamine (58:00) The modes of delivery and forms of thiamine (01:07:06) Outro   For more information, please see the links below. Thank you for listening!   Links:   Resources Mentioned in this Episode:     Elliot Overton: EO Nutrition: https://www.eonutrition.co.uk Objective Nutrients: https://www.objectivenutrients.com X: https://x.com/EO_Nutrition   Dr. Brian Lenzkes:  Arizona Metabolic Health: https://arizonametabolichealth.com/ Low Carb MD Podcast: https://www.lowcarbmd.com/   HLTH Code: HLTH Code Promo Code: METHEALTH • • HLTH Code Website: https://gethlth.com

Send us Fan MailHow light regulate circadian rhythms, mitochondrial function, hormones, and appetite.Nick & Dr. Alexis Cowan discuss non-image-forming effects of light on the body, from melanopsin-driven circadian signaling in the eye to UV-stimulated pathways in skin and brain that influence melatonin, cortisol, melanin production, and energy balance.TOPICS DISCUSSED:Melanopsin & non-image-forming light: blue light signals daytime to the SCN master clock, suppressing melatonin and promoting alertness.UV light, POMC & peptide hormones: UVB exposure in skin and hypothalamus produces alpha-MSH (reduces appetite, boosts energy expenditure) and beta-endorphin (improves mood), independent of vitamin D.Mitochondrial effects of light: red/infrared supports function like a gas pedal; isolated blue light acts as brakes, impairing energy production and biophoton signaling.Artificial light: Evening blue light from screens inhibits melatonin, poisons mitochondria, and creates discordant timing signals versus balanced natural sunlight.Melanin beyond skin: produced via UVB, it harnesses energy, buffers oxidative stress, and links to dopamine pathways; low sun exposure ties to metabolic issues and conditions like Parkinson's.Vitamin D as biomarker: supplementation shows limited benefits because it reflects broader UVB-driven processes, not a standalone fix.ABOUT THE GUEST: Alexis Cowan, PhD earned her PhD in molecular biology at Princeton in the Rabinowitz lab, a leading metabolism research group, where she studied fasting, ketogenic diets, and exercise; she completed a postdoc at UPenn before shifting focus to circadian and quantum biology. She now educates on light, mitochondria, and quantum biology.RELATED EPISODE:M&M 221: Regenerative Energy & the Light Inside You | Jack KruseSupport the showHealth Products by M&M Partners:AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models.KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime)Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app.SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off.Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off.For all the ways you can support my efforts

If you've been hearing about peptides everywhere lately and wondering what they actually are — or whether they're safe, effective, or just another trend — this episode will give you clarity. Because peptides are not just another wellness trend. They are quickly becoming one of the most talked-about tools in health optimization, fat loss, anti-aging, and longevity — and when used correctly, they can be truly transformational. In this episode, I'm joined by Jay Campbell, health optimization pioneer, five-time international bestselling author, and co-founder of BioLongevity Labs. With over two decades of experience in peptides, hormone optimization, and human longevity, Jay breaks down what peptides actually are, how they work, and how to use them safely and effectively. We talk about everything from fat loss peptides and cognitive support to healing, anti-aging, and the importance of hormone optimization. If you're curious about peptides and want a grounded, no-hype explanation of how they actually work — this episode is for you. In This Episode, We Cover: What peptides are and why they're considered a "quantum shift" in health How peptides act as signaling molecules in the body The connection between hormone optimization and peptide effectiveness The truth about GLP-1 peptides and common side effects Why most negative peptide experiences come from misuse Where beginners should start with peptides The concept of stacking peptides and how to do it safely Peptides for fat loss, healing, cognition, and anti-aging Why lifestyle and habits still matter when using peptides The future of peptides in health and wellness Resources: Are you a health coach in need of done-for-you content? Visit yourhealthcoachbiz.com and save 40% using code GO40. Launch your podcast or get full podcast management services here: https://rachelafeldman.com/the-healthy-hustle-podcast-agency/ Connect with Jay Campbell: Website: https://jaycampbell.com Peptides & Products: https://biolongevitylabs.com Instagram: https://www.instagram.com/jaycampbell333/ Free Resources (Books & Guides): https://jaycampbell.com/free-info About Jay Campbell Jay Campbell is a health optimization pioneer, five-time international bestselling author, and co-founder of BioLongevity Labs, a leading peptide and bioregulator company. With over two decades of experience in peptides, hormone optimization, and human longevity, Jay translates complex biomedical research into practical, evidence-based strategies that help people improve their metabolism, vitality, and overall well-being. His work focuses on helping individuals optimize their biology, extend their healthspan, and live with greater energy and intention. What Are Peptides and Why Are They So Powerful? So let's start here — peptides are essentially chains of amino acids that act as signaling molecules in the body. And what makes them so powerful is that they don't just mask symptoms — they communicate with your body at a cellular level. Jay explains that peptides can help address the root cause of illness, disease, and dysregulation, which is why they're being seen as a major shift in modern health. Jay: "Peptides really do represent what I call a fundamental, if not quantum change in health… they address the root cause of illness, disease, and dysregulation." Why Hormone Optimization Comes First Before jumping into peptides, Jay emphasizes something critical: If your hormones are not balanced, your results with peptides will be limited. Many people today are unknowingly dealing with hormone deficiencies due to stress, environment, and lifestyle. Jay: "If you have a hormone deficiency, it's much harder to experience transformational results from peptides." The Truth About GLP-1 Peptides GLP-1 peptides are one of the most talked-about topics right now — especially for fat loss. But Jay explains that the negative side effects people hear about are usually due to: Starting at too high of a dose Poor lifestyle habits When used correctly — especially through microdosing and proper lifestyle support — these peptides can be incredibly effective. Jay: "The side effects… are dose and lifestyle related." Where to Start with Peptides If you're new to peptides, it can feel overwhelming. Jay recommends starting with your biggest need — not everything at once. For many people, that's fat loss or metabolic health. From there, you can layer in other peptides for: Sleep Recovery Healing Cognitive support The key is to keep it simple and intentional. What Is Peptide Stacking? Stacking peptides means combining different peptides together to enhance results. But this is considered more advanced. Jay recommends: Start with one peptide Learn how your body responds Then gradually introduce combinations He also explains the importance of cycling peptides to avoid receptor fatigue. Peptides for Healing, Brain Health, and Anti-Aging One of the most exciting aspects of peptides is how versatile they are. There are peptides designed for: Injury recovery and healing Brain function and memory Anti-aging and skin health Mitochondrial support Some peptides even show potential in supporting neurodegenerative conditions — highlighting how powerful this space is becoming. Why Lifestyle Still Matters Peptides are powerful — but they are not magic. Jay emphasizes that results come from combining peptides with: Proper nutrition Strength training Cardiovascular exercise Hormone optimization Without these, even the best peptides won't deliver optimal results. The Future of Peptides As research continues to grow, peptides are becoming more accessible and more advanced. From new delivery systems to more targeted therapies, Jay believes peptides will continue to transform how we approach health, longevity, and performance. Final Thoughts Peptides represent a powerful tool in modern wellness — but like any tool, they must be used correctly. When combined with the right lifestyle, proper guidance, and a clear understanding of your body, they can support true transformation at a deeper level.

A rare disorder, a surprisingly basic biological question, and a paper that revisits what GLYCTK actually does. Jörn Oliver Sass joins the podcast to discuss D-glyceric aciduria, mitochondrial localization of D-glycerate kinase, and why getting the fundamentals right still matters. Human D-Glycerate Kinase, Encoded by GLYCTK and Deficient in D-Glyceric Aciduria, Is a Mitochondrial Enzyme Anne Korwitz-Reichelt, et al https://doi.org/10.1002/jimd.70119

If you want to get leaner and live longer check out https://milliondollarbodylabs.com Have you ever been sidelined by an injury and wondered if there was a way to bypass the "Netflix and chill" recovery method to heal 30% faster?   I put together a compilation to show how to bulletproof your body. I talk with Michael Roviello about baths and fat. He explains how therapy helps mitochondria. Gary Brecka discusses how oxygen prevents disease and warns against the pathway of injuries. I explain how restriction training triggers hormones. I demonstrate using bands for compression to flush waste and I also detail using a ball to release spasms. These methods help you recover from surgery or pain without relying on ibuprofen. Key Takeaways Ice baths trigger a nervous system shift that reduces inflammation and can induce a meditative state through theta brainwaves. Brown fat acts as a thermogenesis process that converts visceral fat into heat when the body is exposed to cold environments. Mitochondrial function is the core of optimal health, and it can be improved through red light therapy and cold shock proteins. Blood Flow Restriction (BFR) training can speed up recovery by 30% by inducing a hormonal cascade of HGH and IGF-1. The presence of oxygen is the absence of disease, as hypoxia is at the root of nearly every major health issue. Voodoo bands provide mechanical compression to flush out waste products and reestablish full range of motion in joints. Contrast therapy creates a "pump effect" in blood vessels by alternating between hot and cold to move nutrients to injured areas. Resources  Nate Palmer: The founder of The Million Dollar Body and author of "The Million Dollar Body Method", Nate has been coaching for over 15 years and has worked personally with over 1,000 clients.   Website: https://milliondollarbodylabs.com Book: The Million Dollar Body Method Lean Energy Stack: https://milliondollarbodylabs.com/pages/lean Instagram: @_milliondollarbody

Catharine Arnston, the founder of ENERGYBits and a passionate advocate for wellness and entrepreneurship, joins me today to share her incredible story.  Catharine's path to entrepreneurship was unplanned. She was in international business before her sister's cancer diagnosis turned her world upside down. After researching plant-based nutrition, Catharine uncovered the power of algae as a superfood, leading to the creation of ENERGYBits.  Despite not having a background in nutrition or science, she dedicated herself to studying and spreading the word about algae's numerous benefits. ENERGYBits has become a billion-dollar wellness industry leader, and Catharine's commitment to health and entrepreneurship is more than evident. "If you are terrified, you are on the right path. Because it pushes you out of your comfort zone to learn something new that you'll need to get to the next level. " ~ Catharine Arnston In This Episode: - The journey from doubts to entrepreneurship - Surviving the struggle years in Boston - Shark Tank experience and post-show growth - Protein and amino acid content in algae - Spirulina's fast absorption and cyanobacteria structure - Mitochondrial health and cellular energy - How to take ENERGYBits's spirulina and chlorella - Avoiding supplement overload with algae - Bootstrapping ENERGYBits Purchase ENERGYBits' Algae Tablets at a Special Discount! Use the code “JENGOTTLIEB” at: https://energybits.com/discount/JENGOTTLIEB?rfsn=9030997.ddfb9f&utm_source=refersion&utm_medium=affiliate&utm_campaign=9030997.ddfb9f  About Catharine Arnston: Catharine Arnston is a wellness thought leader, experienced entrepreneur, and expert in algae nutrition, with a PhD, MBA, BA Hons, and board certification as a health coach. Her journey into algae began in 2008 when her sister's breast cancer diagnosis led her to discover the healing potential of algae, the most alkaline, nutrient-dense food in the world. Catharine left her 25-year corporate career to launch ENERGYbits® and has spent 15 years researching algae, lecturing at conferences, and speaking on 300+ podcasts to spread its benefits. Her efforts have earned endorsements from organizations like NASA and the United Nations.  Websites: https://energybits.com/  and https://catharinearnston.com/  Instagram: https://www.instagram.com/energybits/   Where to find me: IG: https://www.instagram.com/jen_gottlieb/    TikTok: https://www.tiktok.com/@jen_gottlieb     Facebook: https://www.facebook.com/Jenleahgottlieb    Website: https://jengottlieb.com/    My business: https://www.superconnectormedia.com/     YouTube: https://www.youtube.com/@jen_gottlieb

"I walked out of that appointment freaked out... no one seemed to see it but me". Brad Pitzele was a young father losing his functionality to what doctors called "minor" issues—until it became a fight for his life. Brad Pitzele, CEO of 1000 Roads, shares his harrowing journey through "medical gaslighting," a $500 test that changed everything, and why he ultimately built his own medical-grade oxygen system in his garage. Discover how 15 minutes of "hijacking" your physiology can do more for your cells than hours in a traditional hyperbaric chamber.3 Takeaways:(1) The 1% Rule: Our oxygen levels drop 1% every year after age 25; learn how to reverse this "energy leak".(2) The "Third Path": Why you should never accept a binary choice in healthcare and how to stay curious enough to find a better way.(3) Mitochondrial "Feeding": How oxygen and red light therapy work together to "power up" your cells.Ready to be your own health advocate? Download Brad's free protocol guide at https://BradTalksHealth.com

We discuss the diagnosis and treatment of one of EM's paradoxes: High-Output Heart Failure. Hosts: Nicolas Gonzalez, MD Brian Gilberti, MD https://media.blubrry.com/coreem/content.blubrry.com/coreem/HOHF.mp3 Download Leave a Comment Tags: Cardiology Show Notes Core EM Modular CME Course Maximize your commute with the new Core EM Modular CME Course, featuring the most essential content distilled from our top-rated podcast episodes. This course offers 12 audio-based modules packed with pearls! Information and link below.  Course Highlights: Credit: 12.5 AMA PRA Category 1 Credits™ Curriculum: Comprehensive coverage of Core Emergency Medicine,  with 12 modules spanning from Critical Care to Pediatrics. Cost: Free for NYU Learners $250 for Non-NYU Learners Click Here to Register and Begin Module 1 1. Core Definition & Hemodynamic Profile Clinical Paradox: Congestive symptoms (pulmonary edema, JVD, peripheral edema) in the setting of a hyperdynamic, supranormal cardiac function. Hemodynamic Criteria: Cardiac Index (CI): >4.0 L/min/m2. Cardiac Output (CO): >8 L/min. Systemic Vascular Resistance (SVR): Pathologically low (vasodilated or shunted state). The “Warm” Phenotype: Unlike standard HFrEF/HFpEF (often “Cold and Wet”), HOHF presents as “Warm and Wet” due to low SVR and bounding pulses. 2. Pathophysiology: The Hemodynamic Paradox Primary Insult: Decreased SVR (either via peripheral vasodilation or arteriovenous shunting). Effective Arterial Blood Volume: Paradoxically low despite high total CO. Neurohormonal Cascade: Activation of Renin-Angiotensin-Aldosterone System (RAAS). Increased Sympathetic Nervous System tone. Increased Antidiuretic Hormone (ADH) secretion. Resultant State: Avid renal salt and water retention leading to massive plasma volume expansion. Cardiac Response: Chronic volume overload → eccentric remodeling → chamber dilation → eventual secondary myocardial failure/dilated cardiomyopathy. 3. Differential Diagnosis: Etiological “Buckets” Category A: Increased Metabolic Demand (Systemic) Hyperthyroidism/Thyrotoxicosis: Direct T3 effects: increased chronotropy/inotropy. Indirect effects: metabolic byproduct accumulation causing peripheral vasodilation. Myeloproliferative Disorders: High cell turnover and increased oxygen consumption drive compensatory CO increase. Sepsis (Hyperdynamic Phase): Cytokine-mediated global vasodilation. Note: Often transient; may transition to sepsis-induced myocardial depression. Category B: Peripheral Vascular Effects (Shunting/Vasodilation) Arteriovenous Fistulas (AVF) / Malformations (AVM): Most Common Cause: Iatrogenic AVF for Hemodialysis (ESRD population). Bypasses high-resistance capillary beds, dumping arterial blood directly into venous circulation. Chronic Liver Disease (Cirrhosis): Formation of “spider angiomata” and internal AV shunts. Impaired clearance of endogenous vasodilators (e.g., Nitric Oxide). Thiamine Deficiency (Wet Beriberi): Accumulation of pyruvate/lactate → systemic vasodilation. Histopathology: Vacuolation, myofiber hypertrophy, and interstitial edema. Chronic Lung Disease: Hypoxia/Hypercapnia-driven systemic vasodilation. Concomitant pulmonary HTN (RV remodeling) but preserved/high LV output. Others: Paget's disease of bone (extensive micro-shunting), Carcinoid syndrome, Mitochondrial diseases, Acromegaly, Erythroderma. 4. Special Focus: Hemodialysis Access-Induced HOHF Physiologic Phases of AVF Creation: Acute Phase: Immediate ↓ SVR. ↑ Stroke volume and Heart Rate (SNS-mediated). Endothelial shear stress → Nitric Oxide release → further arterial dilation. Subacute Phase (Days to 2 Weeks): RAAS-driven volume expansion. ↑ Right Atrial, Pulmonary Artery, and LV End-Diastolic Pressures (LVEDP). Natriuretic peptide surge (BNP/ANP) peaks around Day 10. Chronic Phase (Weeks to Months): Adaptive hypertrophy. Decompensation occurs when dilation exceeds contractility limits. 5. Point-of-Care Physical Exam & Maneuvers Nicoladoni-Branham Sign (Pathognomonic for Shunt-driven HOHF): Maneuver: Manually compress the AVF (or inflate cuff to >50 mmHg above SBP) for 30 seconds. Positive Result: Reflexive bradycardia or a transient rise in systemic BP. Significance: Confirms the shunt is a major contributor to the cardiac workload. Peripheral Pulse Assessment: Water Hammer Pulses: Rapid upstroke and collapse. Quincke's Pulse: Visible capillary pulsations in the nail beds. Traube's Sign: “Pistol-shot” sounds auscultated over the femoral arteries. Volume Status: Rales, S3 gallop, peripheral edema (standard HF signs). 6. Diagnostic Workup (Technical Targets) POCUS / Echocardiography: Left Ventricle: Hyperdynamic function; EF typically >60%. Left Atrium: Significant dilation (Left Atrial Volume Index >34 mL/m2; Case study noted 72 mL/m2). IVC: Plethoric with minimal respiratory variation. Doppler: High flow velocities across the AV access if applicable. Laboratory Evaluation: BNP/NT-proBNP: Often markedly elevated (e.g., >70,000 in severe cases), though mean values in literature hover around 700–800 pg/mL. Hematology: CBC to evaluate for severe anemia (trigger for HOHF if Hgb7–8 g/dL to reduce demand. Beriberi: High-dose IV Thiamine (100–500 mg). Thyrotoxicosis: Beta-blockers (Propranolol) + Antithyroid meds (PTU/Methimazole). Phase 3: Surgical/Interventional Salvage (Refractory AVF Cases) Closure of Accessory Sites: If multiple fistulas exist, close the non-dominant/unused sites. Flow Reduction (Banding): Surgical narrowing of the fistula to target flow

Understanding the Signals That Control Your Metabolism If you feel like your body isn't responding the way it used to… you're not alone. You may be eating well, training consistently, and doing everything you've been told should work—yet your energy is off, recovery is slower, and body composition is changing. This series explains why. In this multi-part deep dive, Debbie Potts—Functional Diagnostic Nutrition Practitioner and Metabolic Health Coach—walks you through what is really happening beneath the surface. This is not a conversation about eating less or exercising more. It is about understanding how your body communicates. Because your metabolism is not just about calories or hormones. It is controlled by a network of signals between your brain, gut, muscles, mitochondria, and nervous system. When those signals become disrupted, the body adapts in ways that can feel frustrating and confusing. Fatigue, weight gain, hormone imbalances, and poor recovery are not random. They are clues. Debbie refers to this as "Metabolic Chaos"—a state where the body is no longer communicating efficiently. Throughout this series, you will learn how to recognize the patterns behind metabolic dysfunction and how to begin restoring balance by improving communication within the body. Topics covered in this series include: Why metabolism changes in midlife and what is actually driving those changes How stress, sleep, and the nervous system influence fat metabolism and energy The connection between gut health, inflammation, and hormone balance Why cell membrane health and receptor function are critical for results The role of muscle in long-term metabolic health and aging How mitochondrial function influences energy, endurance, and recovery This series also introduces a more personalized, data-driven approach to health. Rather than guessing, Debbie explains how functional testing can reveal where your body is struggling, including: Functional blood chemistry DUTCH hormone testing GI-MAP stool analysis 3x4 genetic insights PNOĒ metabolic testing Mitochondrial and oxidative stress markers You will also be introduced to the key signals that regulate metabolism, including blood sugar control, cellular health, energy production, gut function, inflammation, detoxification, and recovery. When these systems are aligned, the body works more efficiently. When they are not, progress can feel stalled—even when effort is high. This series is designed to help you connect the dots, understand your body at a deeper level, and begin creating a strategy that works with your physiology instead of against it. If you are ready to stop guessing and start understanding your unique physiology, you can learn more and schedule a FutureYou Blueprint Discovery Call at: www.debbiepotts.net Your body is not working against you. It is responding to the signals it receives. When you understand those signals, you can begin to change your trajectory and build your FutureYou from the inside out.

Episode 2777 - Vinnie Tortorich speaks to nurse practitioner Cynthia Thurlow about her upcoming book and the importance of optimizing your gut. https://vinnietortorich.com/2026/03/optimizing-your-gut-cynthia-thurlow-episode-2777 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Vinnie's workout videos are available to purchase! Choose from a 2-day, 4-day, or 6-day workout–or buy all three at a discount! TO PURCHASE VINNIE'S WORKOUT VIDEOS, CLICK THIS LINK: https://vinnietortorich.com/workout Optimizing Your Gut Cynthia Thurlow is a nurse practitioner and has her own podcast, "Everyday Wellness," which focuses on women's health. (2:00) She has a book coming out, "The Menopause Gut," scheduled for release in late April 2026. You can go directly to her website and pre-order it. https://www.cynthiathurlow.com GLP1s can be helpful for morbidly obese people, but people who are not obese shouldn't be on them. Recent photos of certain celebrities show muscle wasting, which can lead to being fragile and long-term damage. Vinnie has concerns about GLP1s over the long term. What are some definitions of perimenopause, menopause, and post menopause? (27:30) The gut is important for hormonal health because it helps break down hormones for use in the body. Vinnie shares a story about his Mom and why the idea of hormones doesn't always sit well with him. (32:00) There is a difference between birth control pills and the bioidentical hormones of today. Hormones play a significant role in multiple organ systems, including the heart, bones, and brain. Is testosterone replacement necessary for men or women? (44:00) You still have to lead a healthy lifestyle; hormone replacement isn't a band-aid for a bad lifestyle. Mitochondrial health also plays a big role. (49:00) Sleep is foundational to your metabolic health as well. (54:00) Vinnie asks about DHEA and whether supplementation is beneficial. (57:00) What are things we can optimize for our health as we enter perimenopause and andropause? (1:04:00) Fiber from food is helpful for the gut for various reasons. Cynthia shares cautionary tales about being a long-term carnivore. (1:10:00) They discuss certain food addictions, especially to sugar and sweeteners. (1:13:00) A New Sponsor Jaspr Air Scrubbers has a discount code, VINNIE, that gets you $300 off for a limited time. Jaspr offers a lifetime warranty. Go to Jaspr.co for more information or to purchase. (1:05:00) You can book a consultation with Vinnie to get guidance on your goals. https://vinnietortorich.com/phone-consultation-2/ More News Serena has added some of her clothing suggestions and beauty product suggestions to Vinnie's Amazon Recommended Products link. Self Care, Beauty, and Grooming Products that Actually Work! https://www.amazon.com/shop/vinnietortorich/list/3GPVU29UHHPMY?ref_=aipsflist Don't forget to check out Serena Scott Thomas on Days of Our Lives on the Peacock channel. "Dirty Keto" is available on Amazon! You can purchase or rent it here.https://amzn.to/4d9agj1 Please make sure to watch, rate, and review it! Eat Happy Italian, Anna's next cookbook, is available! You can go to https://eathappyitalian.com You can order it from Vinnie's Book Club. https://amzn.to/3ucIXm Anna's recipes are in her cookbooks, on her website, and on Substack —they will spice up your day! https://annavocino.substack.com/ PURCHASE DIRTY KETO (2024) The documentary launched in August 2024! Order it TODAY! This is Vinnie's fourth documentary in just over five years. Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries Then, please share my fact-based, health-focused documentary series with your friends and family. Additionally, the more views it receives, the better it ranks, so please watch it again with a new friend! REVIEWS: Please submit your REVIEW after you watch my films. Your positive REVIEW does matter! PURCHASE BEYOND IMPOSSIBLE (2022) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY 2 (2021) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries FAT: A DOCUMENTARY (2019) Visit my new Documentaries HQ to find my films everywhere: https://vinnietortorich.com/documentaries

Welcome back to Ask the Egg Whisperer! I'm so excited to have Dr. Steven Palter join me on today's episode. Dr. Palter is the medical and scientific director at Gold Coast IVF in Woodbury, New York, and an internationally recognized leader in fertility treatment. He's also the creator of the PCOS to Pregnancy Protocol -  the first comprehensive remote system targeting the root causes of PCOS and the Palter Fertility Method, a personalized approach to diagnosis and care that integrates metabolic health, surgical precision, and emerging reproductive technologies. Watch the full conversation (with more live chatted questions) on Dr. Aimee's Instagram Live.  In this episode, we tackle real questions from our community (women ranging from 36 to 47), dealing with everything from diminished ovarian reserve and repeated IVF failure to PCOS, endometriosis, and experimental treatments like mitochondrial replacement therapy. Dr. Palter and I don't always agree, and that's what makes this conversation so valuable. We get into the nuances of DHEA and testosterone supplementation, when genetic testing is worth it even with limited embryos, why your stimulation protocol might be the problem, and how targeting insulin resistance can transform outcomes for PCOS patients. In this episode, we cover: Why AMH predicts egg quantity, not quality  and why that distinction matters The truth about DHEA and testosterone priming, including a major new study showing no benefit Mitochondrial replacement therapy (three-parent IVF): promise, limitations, and what the data actually shows Fresh vs. frozen transfers with diminished ovarian reserve, and why PGTA testing is still valuable The #1 reason for immature eggs and no blasts and the protocol fix that works 80% of the time Endometriosis, BCL6 testing, and when suppression vs. surgery makes sense How targeting insulin resistance and inflammation in PCOS patients is changing outcomes dramatically Resources: Dr. Steven Palter's practice: Gold Coast IVF — goldcoastivf.com PCOS to Pregnancy Protocol by Dr. Palter Previous podcast episode with Dr. Palter on the Palter Fertility Method Dr. Aimee's fertility supplement stack Would you like to learn more about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, April 20, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom.   Subscribe to my YouTube channel for more fertility tips! Join Egg Whisperer School Subscribe to the newsletter to get updates Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.   Keywords fertility, IVF, egg quality, AMH, diminished ovarian reserve, DHEA, testosterone priming, PCOS, insulin resistance, mitochondrial replacement therapy, three-parent IVF, PGTA, PGT-A, genetic testing, embryo testing, endometriosis, BCL6, frozen embryo transfer, fresh transfer, egg maturity, dual trigger, ovarian PRP, progesterone support, IVF protocol, fertility doctor, reproductive endocrinology, Ask the Egg Whisperer, Dr. Aimee, Dr. Steven Palter, Gold Coast IVF, fertility supplements, CoQ10, NAD, rapamycin, hydrosalpinx, IVF failure, recurrent implantation failure, translocation, modified natural cycle

Today, I'm joined by the extraordinary Dr. Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age.   Episode Timestamps: Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00 Maternal inheritance and critical functions of mitochondria ... 00:05:56 Mitochondria as energy producers and hormone regulators ... 00:07:03 Aha moments: mitochondria control life, death, and disease ... 00:08:55 Endosymbiotic theory: how mitochondria originated ... 00:10:19 Chronic disease, aging, and the connection to mitochondria ... 00:16:10 Substrate fuels: carbs, fats, and importance of metabolic flexibility ... 00:20:18 Mitochondria's control over immune system and signaling ... 00:26:39 Mitochondrial transfer: how cells share organelle "powerhouses" ... 00:32:42 Groundbreaking therapy: transplanting mitochondria for rare diseases ... 00:36:40 Expanding mitochondrial therapies to age-related diseases ... 00:42:57 Aging in women: hormones, mitochondria, and inflection points ... 00:51:00 Stem cell exhaustion and cellular renewal ... 00:52:24 Biomarkers: ways to measure mitochondrial health ... 01:03:11 Supplements, lifestyle, and emotional health for mitochondria ... 01:15:47 Medication choices and minimizing mitochondrial toxicity ... 01:24:04   Our Amazing Sponsors: O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off.   Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT   Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

Today, I'm delighted to reconnect with Dr. Elizabeth Yurth. Dr. Yurth is a double-board-certified physician in physical medicine and rehabilitation and anti-aging regenerative medicine. With over 30 years of clinical experience, she is at the forefront of orthopedics, cellular and regenerative medicine, and the future of aging. In our discussion today, we explore mitochondrial health as the driver of energy changes in middle age and beyond. We discuss the value of hormone replacement, examine the effects of chronic pain and mitochondrial dysfunction, and discuss specific fuels that benefit the mitochondria. We clarify the importance of starting with energy production and repairing mitochondria, and explain the intricate connection between muscle and mitochondrial health. Dr. Yurth also shares the two specific labs that indicate poor mitochondrial health, and we dive into how peptides support immunity and seasonal cycling. I know you will gain from today's conversation with Dr. Elizabeth Yurth, which is truly one of my favorite recent conversations. IN THIS EPISODE, YOU WILL LEARN: How immunosenescence accelerates aging- particularly in women How thymic peptides can support and repair immune functioning   Why mitochondria are foundational to our overall health How mitochondrial decline can increase insomnia and anxiety The value of seasonal cycling for aligning with natural seasonal changes, optimizing adaptation, and reducing unnecessary stress The benefits of longitudinal tracking  How orthorexia and excessive focus on longevity routines can increase anxiety and undermine any health benefits How aging naturally decreases hormones, mitochondrial function, and cellular repair mechanisms Using peptides as a “cheat” to maintain immune and mitochondrial function when daily routines or travel make ideal practices impossible Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com. Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Elizabeth Yurth Boulder Longevity Institute Human Optimization Academy Instagram YouTube

In today's episode, Aaron explores the intricacies of aging, stress, and longevity alongside special guest David Watumull, CEO of AX3 Life and dedicated expert in the world of nutrition and health science. Together, they break down how chronic stress, diet, exercise, and even our emotional state play a critical role in either accelerating or slowing the aging process. David shares fascinating insights about astaxanthin (a powerhouse antioxidant sourced from nature) and its remarkable potential to extend lifespan, improve overall health, and combat the effects of oxidative stress and chronic inflammation. ========== OUR GUEST ========== Dave Watumull is on a mission to bring astaxanthin to the world. This marine super nutrient supports whole body health and longevity and has captured his imagination for more than 25 years of research, development, and commercialization. He is the Co-Founder and CEO of AX3 Life, a consumer health company dedicated to astaxanthin products, education, and community. He is also the COO of Cardax, a life sciences business focused on pharmaceutical and nutraceutical applications of astaxanthin. ============== DAVID WATAMULL ==============

Brad Marshall and Dr Michael Lisanti join David Gornoski to discuss how anti-ageing research is connected to treating cancer, whether striving for a high metabolic rate is wise, antioxidants vs antibiotics in cancer treatment, reductive stress, effectiveness of B Vitamins, and more.  Follow Brad Marshall on X here. Visit Lunella Biotech's website here. Follow David Gornoski on X here. Visit aneighborschoice.com for more

In this episode, I sit down with Daria Mochly-Rosen to explore the powerful role mitochondria play in our energy, brain health, metabolism, and long term resilience. We talk about the science behind sleep, strength training, stress, and nutrition, and how simple daily habits can support better healthspan without falling into burnout or extreme biohacks.We also cover the cultural pressure to hustle nonstop, why slowing down is not a weakness, and how connection, family, and meaningful conversations can actually support your biology. She breaks down the fascinating truth about how we inherit mitochondria, how lifestyle choices influence cellular health, and why it is never too late to start building stronger, more resilient energy from the inside out.→ Leave Us A Voice Message! Topics Discussed:→ What are mitochondria?→ How to boost energy?→ Does sleep affect health?→ Best habits for longevity?→ Are mitochondria inherited?Sponsored By: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership→ Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com.→ Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies.→ Fatty 15 | Fatty15 is on a mission to replenish your C15 levels and restore your long-term health. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/KELLY15 and using code KELLY15 at checkout.Timestamps: → 00:00:00 - Introduction→ 00:01:57 - What are mitochondria?→ 00:02:48 - Mitochondria in each cell→ 00:03:46 - Krebs cycle, ATP + metabolism→ 00:06:24 - Cellular energy production→ 00:08:22 - Nutrition for energy→ 00:14:08 - Healthy vs refined carbs→ 00:17:05 - Sugar + metabolic health→ 00:19:12 - Fad diets explained→ 00:23:45 - Lifestyle changes for longevity→ 00:30:33 - Stress + mitochondrial health→ 00:35:59 - Mitophagy + autophagy benefits→ 00:40:46 - Glymphatic brain detox→ 00:43:09 - Exercise + movement science→ 00:49:10 - Mitochondrial peptides→ 00:55:16 - MOTS-C peptide benefits→ 00:56:35 - Chronic disease + mitochondria→ 01:02:38 - Reactive oxygen species→ 01:07:36 - Family, connection + health→ 01:12:07 - Fertility + energy health→ 01:15:01 - Building healthy mitochondriaFurther Listening: → The Key to Longevity: Exploring Mitochondrial Uncoupling with Dr. Steven GundryCheck Out Daria:→ Stanford | https://med.stanford.edu/profiles/daria-mochly-rosen→ Linkedin | https://www.linkedin.com/in/daria-mochly-rosen-9733bb198→ Book |