Anesthesiology Journal's podcast

Moderator: James P. Rathmell, M.D. Participants: Carmen Bozic, M.D. Articles Discussed: Suzetrigine, a Nonopioid NaV1.8 Inhibitor for Treatment of Moderate-to-severe Acute Pain: Two Phase 3 Randomized Clinical Trials Suzetrigine: First in a New Class of Nonopioid Analgesics for Acute Pain

Moderator: James P. Rathmell, M.D. Participants: Rebecca L. Wu, M.D. and Max B. Kelz, M.D., Ph.D. Articles Discussed: TAK-925 (danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-Induced Respiratory Depression and Sedation Without Affecting Analgesia in Healthy Adult Males Alluring Potential to Accelerate Emergence and Ameliorate Opioid-induced Respiratory Depression without Antagonizing Analgesia: Danavorexton Enters the Anesthetic Landscape Transcript

Moderator: BobbieJean, M.D. Participants: Douglas Colquhoun, M.B., M.Sc., M.P.H. and Stephan R. Thilen Articles Discussed: Neuromuscular Blockade and Antagonism in Patients with Renal Impairment: A Multicenter Retrospective Cross Sectional Study On and Off Label Use of Sugammadex in Patients with Renal Impairment in the 6 ½ Years Following FDA Approval Transcript

Creator: James P. Rathmell, M.D., M.B.A. June 2025, Volume 142, Issue 6 Overview of June issue original studies. Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Daqing Ma, Ph.D. and Kate Leslie, M.B.B.S., M.D. Articles Discussed: Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecologic Laparoscopic Surgery: A Double-blind Randomized Controlled Trial B6 or Be Sick? Pyridoxine to Prevent Postoperative Nausea and Vomiting Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Alessandro Belletti, M.D., and Samuel N. Heyman, M.D. Articles Discussed: Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION Trial Amino Acid Infusion for the Prevention of Acute Kidney Injury: Yet a Debatable Issue Transcript

Moderator: James P. Rathmell, M.D. Participants: Christopher Connor, M.D., Ph.D. and Peter John Schuller, M.B.B.S., B.Sc. Articles Discussed: Developing an EEG-based model to predict awakening after cardiac arrest using partial processing with the BIS Engine Unlocking Prognostic Potential in the Postarrest Electroencephalogram Transcript

Creator: James P. Rathmell, M.D., M.B.A. May 2025, Volume 142, Issue 5 Overview of May issue original studies.

Creator: James P. Rathmell, M.D., M.B.A. April 2025, Volume 142, Issue 4 Overview of April issue original studies.

Moderator: James P. Rathmell, M.D. Participants: Yuming Peng, M.D., Ph.D. and Philip Devereaux, M.D., Ph.D. Articles Discussed: Covert Perioperative Strokes in Older Patients Having Noncardiac Surgery (PRECISION): A Prospective Cohort Analysis Perioperative Covert Stroke: Acutely Asymptomatic but Not Benign Transcript

Creator: James P. Rathmell, M.D., M.B.A. March 2025, Volume 142, Issue 3 Overview of March issue original studies.

Moderator: BobbieJean Sweitzer, M.D. Participants: Jai Darvall, Ph.D. and Tong J. Gan, M.D., M.B.A., M.H.S. Articles Discussed: Chewing Gum to Treat Postoperative Nausea and Vomiting in Female Patients: A Multicenter Randomized Trial Chewing Gum: A Viable Option as a Rescue Therapy for Postoperative Nausea and Vomiting? Transcript

Moderator: James P. Rathmell, M.D. Participants: James Hitt, M.D., Ph.D. and Mark C Bicket, M.D., Ph.D. Articles Discussed: Continuation versus Interruption of Buprenorphine/Naloxone in Adult Veterans Undergoing Surgery: Examination of Postoperative Pain and Opioid Utilization in a National Retrospective Cohort Study Building a Better Base for Keeping Buprenorphine on Board for Surgery Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Annie Xin, Ph.D., M.D. and Randall Flick, M.D., M.P.H. Articles Discussed: Neurodevelopmental Outcomes After Multiple General Anaesthetic Exposure Before Five Years Of Age – A Cohort Study Secondary Analyses: The Perils of Making Do Transcript

Creator: James P. Rathmell, M.D., M.B.A. February 2025, Volume 142, Issue 2 Overview of February issue original studies. Transcript

Creator: James P. Rathmell, M.D., M.B.A. January 2025, Volume 142, Issue 1 Overview of January issue original studies.

Moderator: BobbieJean Sweitzer, M.D. Participants: Guido Mazzinari, M.D., Ph.D., M.Sc. and Snehalata Huzurbazar, Ph.D. Articles Discussed: High Positive End-expiratory Pressure (PEEP) with Recruitment Maneuvers versus Low PEEP during General Anesthesia for Surgery: A Bayesian Individual Patient Data Meta-analysis of Three Randomized Clinical Trials Bayesian Analyses Are Appearing and Are Welcome Transcript

Moderator: James P. Rathmell, M.D. Participants: Nicholas Joseph Douville, M.D., Ph.D. and Vesela P. Kovacheva, M.D., Ph.D. Articles Discussed: Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study Polygenic Risk Scores: Coming to Your Operating Room? Transcript

Creator: James P. Rathmell, M.D., M.B.A. December 2024, Volume 141, Issue 6 Overview of December issue original studies. Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Anil Panigrahi, M.D., Ph.D. Articles Discussed: Factor Eight Inhibitor Bypass Activity Use in Cardiac Surgery: A Propensity Matched Analysis of Safety Outcomes Transcript

Moderator: James P. Rathmell, M.D. Participants: Rodney Gabriel, M.D. Articles Discussed: Paravertebral versus Pectoralis-II (Interpectoral and Pectoserratus) Nerve Blocks for Postoperative Analgesia after Non-Mastectomy Breast Surgery: A Randomized, Controlled, Observer-Masked Noninferiority Trial Transcript

Moderator: James P. Rathmell, M.D. Participants: Paul S. Myles, M.B., B.S., M.P.H., M.D., D.Sc. and Daniel I. McIsaac, M.D., M.P.H. Articles Discussed: Dexamethasone for Cardiac Surgery: A Practice Preference-Randomized Consent Comparative Effectiveness Trial Routine Innovation in Perioperative Clinical Trials: The Best Chance to Answer Our Most Important Questions? Transcript

Creator: James P. Rathmell, M.D., M.B.A. November 2024, Volume 141, Issue 5 Overview of November issue original studies.

Moderator: BobbieJean Sweitzer, M.D. Participants: Karim Brohi, M.D. and Richard P. Dutton, M.D., M.B.A. Articles Discussed: Correction of Trauma-induced Coagulopathy by Goal-directed Therapy: A Secondary Analysis of the ITACTIC Trial Tactics versus Strategy in Trauma Resuscitation Transcript

Moderator: James P. Rathmell, M.D. Participants: Daniele De Luca M.D., Ph.D. and David Tingay, M.B.B.S., Ph.D. Articles Discussed: Global and Regional Heterogeneity of Lung Aeration in Neonates with Different Respiratory Disorders: A Physiological, Observational Study Lung Ultrasound and Regional Heterogeneity: A Bedside Solution to an Under-Recognized Problem?

Creator: James P. Rathmell, M.D., M.B.A. October 2024, Volume 141, Issue 4 Overview of October issue original studies.

Moderator: BobbieJean Sweitzer, M.D. Participants: Sebastian J. Corlette, M.B.B.S. and Isabelle Constant, Ph.D., M.D. Articles Discussed: Changes in the Term Neonatal Electroencephalogram with General Anesthesia – A Systematic Review with Narrative Synthesis Challenge of Neonatal Anesthesia: Which Optimal EEG Target? Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Lisa M. Einhorn, M.D. and Charles B. Berde, M.D., Ph.D. Articles Discussed: Single-Dose Intraoperative Methadone for Pain Management in Pediatric Tonsillectomy: A Randomized Double Blind Clinical Trial Improving Pain Management After Tonsillectomy Transcript

Creator: James P. Rathmell, M.D., M.B.A. September 2024, Volume 141, Issue 3 Overview of September issue original studies. Transcript

Moderator: James P. Rathmell, M.D. Participants: Steven L. Shafer, M.D. and David Clark, M.D., Ph.D. Articles Discussed: Safety and Efficacy of Vocacapsaicin for Management of Postsurgical Pain: A Randomized Clinical Trial Sweeping Away Dyspnea A Spicy New Treatment for Postoperative Pain Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Andrew Bowdle, M.D., Ph.D. and Sorin J. Brull, M.D. Articles Discussed: Accuracy and Precision of Three Acceleromyographs, Three Electromyographs and a Mechanomyograph Measuring the Train-of-Four Ratio in the Absence of Neuromuscular Blocking Drugs Vital Sign Data Quality: Not Just a Retrospective Research Problem Accuracy and Precision of Acceleromyography, Electromyography and Mechanomyography: Time to Re-think What We Know Transcript

Creator: James P. Rathmell, M.D., M.B.A. August 2024, Volume 141, Issue 2 Overview of August issue original studies. Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Mathias Maleczek, M.D., and Patrick J. McCormick, M.D., M.Eng. Articles Discussed: A Comparison of Five Algorithmic Methods and Machine Learning Pattern Recognition for Artifact Detection in Electronic Records of Five Different Vital Signs: A Retrospective Analysis Vital Sign Data Quality: Not Just a Retrospective Research Problem Transcript

Creator: James P. Rathmell, M.D., M.B.A. July 2024, Volume 141, Issue 1 Overview of July issue original studies.

Moderator: James P. Rathmell, M.D. Participants: Côme Bureau, M.D., Ph.D. and Nikolaos J. Skubas, M.D. Articles Discussed: Increasing Sweep Gas Flow Reduces Respiratory Drive and Dyspnea in Nonintubated Venoarterial Extracorporeal Membrane Oxygenation Patients: A Pilot Study Sweeping Away Dyspnea

Moderator: BobbieJean Sweitzer, M.D. Participants: Aurora N. Quaye, M.D. and Douglas A. Colquhoun, M.B.Ch.B., M.Sc., M.P.H. Articles Discussed: Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study Does Propofol Improve Polyp Detection during Colonoscopy? The Promise and Peril of Clinical Registry Data

Moderator: James P. Rathmell, M.D. Participants: Albert Dahan, M.D., Ph.D., and Thomas K. Henthorn, M.D. Articles Discussed: Reversal of Propofol-induced Depression of the Hypoxic Ventilatory Response by BK-channel Blocker ENA-001: A Randomized Controlled Trial Reversal for Respiratory Depression: Let's Take a Breath! Transcript

Creator: James P. Rathmell, M.D., M.B.A. June 2024, Volume 140, Issue 6 Overview of June issue original studies. Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Jessica C. Martin, Ph.D., B.Sc. and Jerry Chao, M.D., M.Sc. Articles Discussed: The Topographical Features of Pediatric Electroencephalography during High Initial Concentration Sevoflurane for Inhalational Induction of Anesthesia A Window into the Developing Brain: Toward a Deeper Understanding of Pediatric Anesthesia Transcript

Creator: James P. Rathmell, M.D., M.B.A. May 2024, Volume 140, Issue 5 Overview of May issue original studies. Transcript

Moderator: James P. Rathmell, M.D. Participants: Faraj Abdallah, M.D. and Michael R. Fettiplace, M.D., Ph.D. and Ashraf S. Habib, M.D., M.B.B.Ch., M.Sc., M.H.Sc. and Jonathan Slonin, M.D., M.B.A. Articles Discussed: Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials Meta-analyses of Randomized Clinical Trials in Postsurgical Pain: Verify before Trusting Liposomal Bupivacaine for Abdominal Fascial Plane Blocks: No Evidence or Lack of Relevant Evidence? Liposomal Bupivacaine, Scientific Evidence, and the Clinician's Conundrum Liposomal Bupivacaine's Plausibility Fails to Translate

Creator: James P. Rathmell, M.D., M.B.A. April 2024, Volume 140, Issue 4 Overview of April issue original studies.

Moderator: BobbieJean Sweitzer, M.D. Participants: Maximilian Sebastian Schaefer, M.D. and Amy Gaskell, M.B.Ch.B., Ph.D. Articles Discussed: Intraoperative Use of Phenylephrine versus Ephedrine and Postoperative Delirium: A Multicenter Retrospective Cohort Study Caveat Emptor: Vasopressor Choice and Postoperative Delirium—A Complex Relationship Explored Transcript

Moderator: James P. Rathmell, M.D. Participants: Anahi Perlas, M.D. and Mark Warner, M.D. Articles Discussed: Baseline Gastric Volume in Fasting Diabetic Patients Is Not Higher than That in Nondiabetic Patients: A Cross-sectional Noninferiority Study Diabetic Patients, Assessment of Preoperative Gastric Contents, and Potential Reduction of Risk of Pulmonary Aspiration Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Pavel S. Roshanov, M.D., M.Sc. Articles Discussed: One-Year Outcomes After Discharge from Noncardiac Surgery and Association Between Pre-Discharge Complications and Death After Discharge: Analysis of the VISION Prospective Cohort Study Transcript

Moderator: BobbieJean Sweitzer, M.D. Participants: Scott Segal, M.D., M.H.C.M. and Jeffrey B. Cooper, Ph.D. Articles Discussed: A Quality Improvement Initiative to Reduce Adverse Effects of Transitions of Anesthesia Care on Postoperative Outcomes: A Retrospective Cohort Study Anesthesia Needs to Lead the Way in Safety—Again—through the Universal Adoption of Structured Handoffs

Moderator: James P. Rathmell, M.D. Participants: Mark D. Neuman, M.D., M.Sc. and Elizabeth L. Whitlock, M.D., M.Sc. Articles Discussed: Long-term Outcomes with Spinal versus General Anesthesia for Hip Fracture Surgery: A Randomized Trial REGAINing the Freedom to Choose Insensibility for Hip Fracture Surgery

Creator: James P. Rathmell, M.D., M.B.A. March 2024, Volume 140, Issue 3 Overview of March issue original studies. Transcript

Creator: James P. Rathmell, M.D., M.B.A. February 2024, Volume 140, Issue 2 Overview of February issue original studies.

Moderator: James P. Rathmell, M.D. Participants: Mattia Busana, M.D. and Marcos F. Vidal Melo, M.D., Ph.D. Articles Discussed: The Causes of Hypoxemia of COVID-19 ARDS: A Combined MIGET and Dual-Energy CT Study Structure–Function Relationships Determining Hypoxemia in COVID-19 Acute Respiratory Distress Syndrome

Moderator: BobbieJean Sweitzer, M.D. Participants: Michael F. Aziz, M.D. and Paul S. Myles, M.B., B.S., M.P.H., M.D., D.Sc. Articles Discussed: Perioperative Mortality of the COVID-19 Recovered Patient Compared to a Matched Control: A Multicenter Retrospective Cohort Study COVID-19 and Surgery: Getting Back to Business Transcript